Unnamed: 0
int64 2
562k
| Entry
stringlengths 6
10
| Sequence
stringlengths 11
999
| Protein names
stringlengths 5
558
| Organism
stringclasses 392
values | Organism (ID)
int64 595
2.89M
| Length
int64 11
999
| Mass
int64 1.06k
118k
| Keywords
stringlengths 4
380
⌀ | Gene Ontology IDs
stringlengths 10
754
⌀ | Protein existence
stringclasses 5
values | Annotation
float64 1
5
| Subcellular location [CC]
stringlengths 30
2.26k
⌀ | Signal peptide
stringclasses 677
values | Transmembrane
stringlengths 32
2.52k
⌀ | Pfam
stringlengths 8
72
⌀ | InterPro
stringlengths 10
180
⌀ | PDB
stringlengths 5
2.65k
⌀ | Taxonomic lineage
stringclasses 178
values | Gene Names
stringlengths 2
299
⌀ | Toxin
bool 2
classes | species
stringclasses 111
values | cdhit_cluster
int64 0
4.65k
| cdhit_rep
stringlengths 5
10
| cdhit_rep_is_ref
bool 1
class | cdhit_pct_id
float64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
779 |
Q9P3V0
|
MKNKDYPLRSSMDELSTKNDNEIDLEKGPLPEYNSEDGSTLPPYSEIWKYIKTVSEDSSTGPTEIANPNVERRQEFKDSHPNIYSLLRLLISVLAVIVVFFTAWVCVNPLEKSIFGKVAFSVTIGITCPIVFIVIFCFFETWTQAVAQCIKVTVIFLAQCVKVTAVFLAKCVKVIAVGLYNSKKDLVVTIWLAWVVICFILFGCVKDGRLNLNKALICSTCSISAALFFILLLVCIPIWTLKHMLFGLFQVLGVQSCVVIVTKGLMYLFDKHIDATGYEIEASSLFVIGNFLFFYEMERPGALKRMPKFIGNGIASFLGGLGNAFGGIGNAFGGIGNAIGRIGNAFRGANDNNDIPLGEMDVESEV
|
Meiotic driver wtf4
|
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 284,812 | 366 | 40,360 |
Alternative initiation;Cytoplasm;Endoplasmic reticulum;Membrane;Reference proteome;Toxin;Transmembrane;Transmembrane helix;Vacuole
|
GO:0000324; GO:0005737; GO:0005774; GO:0005789; GO:0072324; GO:0110134
|
Inferred from homology
| 5 |
SUBCELLULAR LOCATION: [Isoform 1]: Spore membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Contained within spores expressing the isoform and localizes isoform 2 to the vacuole. {ECO:0000250|UniProtKB:A0A218N034}.; SUBCELLULAR LOCATION: [Isoform 2]: Ascus epiplasm {ECO:0000250|UniProtKB:A0A218N034}. Cytoplasm {ECO:0000250|UniProtKB:A0A218N034}. Spore membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in trans to all spores within an ascus. Localization to the spore vacuole is dependent on isoform 1. {ECO:0000250|UniProtKB:A0A218N034}.
| null |
TRANSMEM 89..109; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 119..139; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 245..265; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 275..295; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 309..329; /note="Helical"; /evidence="ECO:0000255"
|
PF03303;
|
IPR004982;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Ascomycota (phylum), Taphrinomycotina (subphylum), Schizosaccharomycetes (class), Schizosaccharomycetales (order), Schizosaccharomycetaceae (family), Schizosaccharomyces (genus), Schizosaccharomyces pombe (species)
|
wtf4 wtf13 SPCC548.03c
| true |
Schizosaccharomyces pombe
| 3 |
row_729
| false | null |
167 |
O84616
|
MMEVFMNFLDQLDLIIQNKHMLEHTFYVKWSKGELTKEQLQAYAKDYYLHIKAFPKYLSAIHSRCDDLEARKLLLDNLMDEENGYPNHIDLWKQFVFALGVTPEELEAHEPSEAAKAKVATFMRWCTGDSLAAGVAALYSYESQIPRIAREKIRGLTEYFGFSNPEDYAYFTEHEEADVRHAREEKALIEMLLKDDADKVLEASQEVTQSLYGFLDSFLDPGTCCSCHQSY
|
4-aminobenzoate synthase (EC 1.3.3.-) (Chlamydia protein associating with death domains) (CADD) (para-aminobenzoate synthase) (PABA synthase)
|
Chlamydia trachomatis serovar D (strain ATCC VR-885 / DSM 19411 / UW-3/Cx)
| 272,561 | 231 | 26,734 |
3D-structure;Host cytoplasm;Iron;Metal-binding;Oxidoreductase;Reference proteome;Secreted;Toxin;Virulence
|
GO:0005576; GO:0006790; GO:0016491; GO:0030430; GO:0044281; GO:0046872; GO:0090729; GO:0141072
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11805081}. Host cytoplasm {ECO:0000269|PubMed:11805081}. Note=Secreted into the host cytoplasm, where it co-localizes with Fas in the proximity of the inclusion body. {ECO:0000269|PubMed:11805081}.
| null | null |
PF03070;
|
IPR027572;IPR016084;IPR039068;IPR004305;
|
1RCW;8VA9;8VAB;8VAG;8VAI;
|
cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), PVC group (clade), Chlamydiota (phylum), Chlamydiia (class), Chlamydiales (order), Chlamydiaceae (family), Chlamydia/Chlamydophila group (no rank), Chlamydia (genus), Chlamydia trachomatis (species)
|
CT_610
| true |
Chlamydia trachomatis
| 0 |
row_154
| false | null |
4,596 |
Q4JHE2
|
MNVFFMFSLLFLAALESCADDRRRPLEECFQEADYEEFLEIARNGLNETSNPKHVVVVGAGMAGLSAAYVLAGAGHNVTLLEASERVGGRVNTYRNETEGWYVNLGPMRLPERHRIIREYIRKFGLKLNEFLQENENAWYFIRNIRKRVWEVKKDPGVFKYPVEPSEEGKSASQLYRESLEKVIEELKRTNCSYILNKYDTYSTKEYLIKEGNLSRGAVDMIGKLPNEDSSYYLSFIESLKSDDLFSYEKRFDEIVGGFDQLPISMYQAIAEMVHLNAQVIKIQHNAEEVRVAYQTPAKTLSYVTADYVIVCSTSRAARRIYFEPPLPPKKAHALRSIHYRSGTKIFLTCTRKFWEADGIHGGKSTTDLPSRFIYYPNHNFTSDVGVIVAYTLADDADFFQALDIKTSADIVINDLSLIHQLPKEEIQALCYPSMIKKWSLDKYAMGAITSFTPYQFQDFIETVAAPVGRIYFAGEYTARVHGWLDSTIKSGLTAARDVNRASQKPSRRQLSNDNEL
|
L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2)
|
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
| 70,142 | 517 | 59,058 |
Antibiotic;Antimicrobial;Apoptosis;Cytolysis;Disulfide bond;FAD;Flavoprotein;Glycoprotein;Hemolysis;Hemostasis impairing toxin;Oxidoreductase;Secreted;Signal;Toxin
|
GO:0001716; GO:0005576; GO:0006915; GO:0009063; GO:0031640; GO:0042742; GO:0090729
|
Evidence at transcript level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:16261251}.
|
SIGNAL 1..18; /evidence="ECO:0000250|UniProtKB:P81382"
| null |
PF01593;
|
IPR002937;IPR036188;IPR001613;IPR050281;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Hydrophiinae (subfamily), Notechis (genus), Notechis scutatus (species)
| null | true |
Notechis scutatus
| 0 |
row_4374
| false | null |
513 |
P82807
|
MAPQLLLCLILTFLWSLPEAESNVFLKSKVANRFLQRTKRSNSLFEEIRPGNIERECIEEKCSKEEAREVFEDNEKTETFWNVYVDGDQCSSNPCHYRGTCKDGIGSYTCTCLPNYEGKNCEKVLYQSCRVDNGNCWHFCKRVQSETQCSCAESYRLGVDGHSCVAEGDFSCGRNIKARNKREASLPDFVQSQKATLLKKSDNPSPDIRIVNGMDCKLGECPWQAVLINEKGEVFCGGTILSPIHVLTAAHCINQTKSVSVIVGEIDISRKETRRLLSVDKIYVHTKFVPPNYYYVHQNFDRVAYDYDIAIIRMKTPIQFSENVVPACLPTADFANEVLMKQDSGIVSGFGRIRFKEPTSNTLKVITVPYVDRHTCMLSSDFRITQNMFCAGYDTLPQDACQGDSGGPHITAYRDTHFITGIISWGEGCARKGKYGVYTKVSRFIPWIKKIMSLK
|
Venom prothrombin activator notecarin-D1 (vPA) (EC 3.4.21.6) (Venom coagulation factor Xa-like protease) [Cleaved into: Notecarin-D1 light chain; Notecarin-D1 heavy chain]
|
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
| 70,142 | 455 | 51,464 |
Blood coagulation cascade activating toxin;Calcium;Cleavage on pair of basic residues;Direct protein sequencing;Disulfide bond;EGF-like domain;Gamma-carboxyglutamic acid;Glycoprotein;Hemostasis impairing toxin;Hydrolase;Protease;Prothrombin activator;Repeat;Secreted;Signal;Toxin
|
GO:0004252; GO:0005509; GO:0005576; GO:0005615; GO:0006508; GO:0007596; GO:0016504; GO:0035807; GO:0044469; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10779512, ECO:0000269|PubMed:12403650}.
|
SIGNAL 1..20; /evidence="ECO:0000255"
| null |
PF00008;PF14670;PF00594;PF00089;
|
IPR017857;IPR001881;IPR000742;IPR000152;IPR018097;IPR035972;IPR000294;IPR012224;IPR050442;IPR009003;IPR043504;IPR001314;IPR001254;IPR018114;IPR033116;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Hydrophiinae (subfamily), Notechis (genus), Notechis scutatus (species)
| null | true |
Notechis scutatus
| 1 |
row_477
| false | null |
2,024 |
Q3HXY5
|
MSMLCYTLIIAFLIGIWAAPKSEDNVPLGSPATSDLSDTSCAQTHEGLKTSRNTDQRHPAPKKAEDQELGSVANIIVDPKLFQKRRFQSSRVLFSTQPPPLSRDEQSVEFLDNEDTLNRNIRAKRENHPVHNQGEHSVCDSVSDWVIKTTATDIRGNMVTVMVDINRDNEVYKQYFFETKCRNPNPNPVQSECRGIDSRLWNSYCTTTRTFVRALTMEGNQASWRFIRIDTACVCVIIRKTDNF
|
Venom nerve growth factor 3 (v-NGF-3) (vNGF-3)
|
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
| 70,142 | 244 | 27,789 |
Cleavage on pair of basic residues;Disulfide bond;Growth factor;Lipid-binding;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Secreted;Signal;Toxin
|
GO:0005163; GO:0005615; GO:0007169; GO:0008021; GO:0008083; GO:0008191; GO:0008289; GO:0021675; GO:0030424; GO:0030425; GO:0038180; GO:0043524; GO:0048812; GO:0050804; GO:0090729
|
Evidence at transcript level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P61898}.
|
SIGNAL 1..18; /evidence="ECO:0000255"
| null |
PF00243;
|
IPR029034;IPR020408;IPR002072;IPR020425;IPR019846;IPR020433;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Hydrophiinae (subfamily), Notechis (genus), Notechis scutatus (species)
| null | true |
Notechis scutatus
| 2 |
row_1943
| false | null |
2,025 |
Q3HXY6
|
MSMLCYTLIIAFLIGIWAAPKSEDNVPLGSPATSDLSDTSCAQTHEGLKTSRNTDQRHPAPKKAEDQELGSAANIIVDPKLFQKRRFQSPRVLFSTQPPPLSRDEQSVEFLDNEDTLNRNIRAKRENHPVHNQGEHSVCDSVSDWVIKTTATDIRGNMVTVMVDINRNNEVYKQYFFETKCRNPNPNPVQSERRGIDSRLWNSYCTTTQTFVRALTMEGNQASWRFIRIDTACVCVIIRKTDNF
|
Venom nerve growth factor 2 (v-NGF-2) (vNGF-2)
|
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
| 70,142 | 244 | 27,795 |
Cleavage on pair of basic residues;Disulfide bond;Growth factor;Lipid-binding;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Secreted;Signal;Toxin
|
GO:0005163; GO:0005615; GO:0007169; GO:0008021; GO:0008083; GO:0008191; GO:0008289; GO:0021675; GO:0030424; GO:0030425; GO:0038180; GO:0043524; GO:0048812; GO:0050804; GO:0090729
|
Evidence at transcript level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P61898}.
|
SIGNAL 1..18; /evidence="ECO:0000255"
| null |
PF00243;
|
IPR029034;IPR020408;IPR002072;IPR020425;IPR020433;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Hydrophiinae (subfamily), Notechis (genus), Notechis scutatus (species)
| null | true |
Notechis scutatus
| 3 |
row_1944
| false | null |
7,075 |
Q3SB04
|
MIAFIVLLSLAAVLQQSSGTVDFASESSNKKDYQKEIVDKHNALRRSVKPTARNMLRMEWNSHAAQNAKRWADRCTFAHSPPHTRTVGKLRCGENIFMSSQPFAWSGVVQAWYDEVKKFVYGIGAKPPGSVIGHYTQVVWYKSHLLGCASAKCSSTKYLYVCQYCPAGNIRGSIATPYKSGPTCGDCPSACVNGLCTNPCKYEDDFSNCKALAKNSKCQTEWIKSKCPAACFCHNKII
|
Cysteine-rich venom protein pseudechetoxin-like (CRVP)
|
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
| 70,142 | 238 | 26,327 |
Disulfide bond;Ion channel impairing toxin;Neurotoxin;Secreted;Signal;Toxin
|
GO:0005576; GO:0090729; GO:0099106
|
Evidence at transcript level
| 2 |
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
|
SIGNAL 1..19; /evidence="ECO:0000250"
| null |
PF00188;PF08562;
|
IPR018244;IPR014044;IPR035940;IPR042076;IPR001283;IPR013871;IPR034117;IPR003582;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Hydrophiinae (subfamily), Notechis (genus), Notechis scutatus (species)
| null | true |
Notechis scutatus
| 4 |
row_6797
| false | null |
2,265 |
Q9PSN5
|
NLYQFGNMIQCANHGRRPTRHYMDYGCYCGKGGSGTPVDELDRCCQTHDDCYGEAEKLPACNYMMSGPYYNTYSYECNEGELTCKDNNDECKAFICNCDRTAAICFARAPYNDANWNIDTKTRCQ
|
Acidic phospholipase A2 HTe (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
|
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
| 70,142 | 125 | 14,262 |
Calcium;Direct protein sequencing;Disulfide bond;Hydrolase;Lipid degradation;Lipid metabolism;Metal-binding;Myotoxin;Neurotoxin;Secreted;Toxin
|
GO:0005102; GO:0005509; GO:0005543; GO:0005576; GO:0006633; GO:0006644; GO:0016042; GO:0047498; GO:0048146; GO:0050482; GO:0090729
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted.
| null | null |
PF00068;
|
IPR001211;IPR033112;IPR016090;IPR036444;IPR033113;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Hydrophiinae (subfamily), Notechis (genus), Notechis scutatus (species)
| null | true |
Notechis scutatus
| 5 |
row_2181
| false | null |
173 |
P00608
|
NLVQFSYLIQCANHGKRPTWHYMDYGCYCGAGGSGTPVDELDRCCKIHDDCYDEAGKKGCFPKMSAYDYYCGENGPYCRNIKKKCLRFVCDCDVEAAFCFAKAPYNNANWNIDTKKRCQ
|
Basic phospholipase A2 notexin (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
|
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
| 70,142 | 119 | 13,593 |
3D-structure;Calcium;Direct protein sequencing;Disulfide bond;Hydrolase;Lipid degradation;Lipid metabolism;Metal-binding;Myotoxin;Neurotoxin;Presynaptic neurotoxin;Secreted;Toxin
|
GO:0005509; GO:0005543; GO:0005576; GO:0006644; GO:0016042; GO:0047498; GO:0050482; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted.
| null | null |
PF00068;
|
IPR001211;IPR033112;IPR016090;IPR036444;IPR033113;
|
1AE7;4E4C;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Hydrophiinae (subfamily), Notechis (genus), Notechis scutatus (species)
| null | true |
Notechis scutatus
| 6 |
row_160
| false | null |
3,038 |
P01384
|
MKTLLLTLVVVTIVCLDLGDSLICYMGPKTPRTCPRGQNLCYTKTWCDAFCSSRGKVVELGCAATCPIAKSYEDVTCCSTDNCNPFPVRPRPHP
|
Alpha-elapitoxin-Nss2a (Alpha-EPTX-Nss2a) (Long neurotoxin 1) (LNTX-1) (Notechis III-4)
|
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
| 70,142 | 94 | 10,289 |
Acetylcholine receptor inhibiting toxin;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Postsynaptic neurotoxin;Secreted;Signal;Toxin
|
GO:0005576; GO:0030550; GO:0090729; GO:0099106
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:497256}.
|
SIGNAL 1..21; /evidence="ECO:0000269|PubMed:497256"
| null |
PF21947;
|
IPR003571;IPR045860;IPR018354;IPR054131;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Hydrophiinae (subfamily), Notechis (genus), Notechis scutatus (species)
| null | true |
Notechis scutatus
| 7 |
row_2936
| false | null |
5,201 |
A8HDK0
|
MKTLLLTLVVVTIVFLDLGYTMTCCNQQSSQPKTTTTCAESSCYKKTWRDHRGTITERGCGCPNVKPGVQINCCKTDECNN
|
Short neurotoxin 1 (SNTX-1)
|
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
| 70,142 | 81 | 8,982 |
Acetylcholine receptor inhibiting toxin;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Postsynaptic neurotoxin;Secreted;Signal;Toxin
|
GO:0005576; GO:0030550; GO:0090729; GO:0099106
|
Inferred from homology
| 2 |
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
|
SIGNAL 1..21; /evidence="ECO:0000250"
| null |
PF21947;
|
IPR003571;IPR045860;IPR018354;IPR054131;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Hydrophiinae (subfamily), Notechis (genus), Notechis scutatus (species)
| null | true |
Notechis scutatus
| 8 |
row_4968
| false | null |
7,065 |
Q3SAE7
|
SGSKTAKIGDGCFGLPLDRIGSTSGMGCGSVPKPTPGGS
|
Natriuretic peptide NsNP-b
|
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
| 70,142 | 39 | 3,681 |
Disulfide bond;Hypotensive agent;Secreted;Toxin;Vasoactive;Vasodilator
|
GO:0005179; GO:0005576; GO:0008217; GO:0042311; GO:0090729
|
Evidence at transcript level
| 2 |
SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:16908092}.
| null | null |
PF00212;
|
IPR000663;IPR030480;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Hydrophiinae (subfamily), Notechis (genus), Notechis scutatus (species)
| null | true |
Notechis scutatus
| 9 |
row_6787
| false | null |
7,066 |
Q3SAE8
|
SGSEVAKIGDGCFGLPLDRIGSASGMGCRSVPKPTPGGS
|
Natriuretic peptide NsNP-a
|
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
| 70,142 | 39 | 3,749 |
Disulfide bond;Hypotensive agent;Secreted;Toxin;Vasoactive;Vasodilator
|
GO:0005179; GO:0005576; GO:0008217; GO:0042311; GO:0090729
|
Evidence at transcript level
| 2 |
SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:16908092}.
| null | null |
PF00212;
|
IPR000663;IPR030480;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Hydrophiinae (subfamily), Notechis (genus), Notechis scutatus (species)
| null | true |
Notechis scutatus
| 10 |
row_6788
| false | null |
6,357 |
P0DL19
|
SNKKDYQKEIVDKHNALRRSVK
|
Cysteine-rich venom protein notescatin (CRVP) (Notescatin-a) (Notescatin-b)
|
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
| 70,142 | 22 | 2,657 |
Direct protein sequencing;Disulfide bond;Secreted;Toxin
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 2 |
SUBCELLULAR LOCATION: Secreted.
| null | null | null | null | null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Hydrophiinae (subfamily), Notechis (genus), Notechis scutatus (species)
| null | true |
Notechis scutatus
| 11 |
row_6109
| false | null |
1,468 |
P0CY52
|
SNSLFEEVRPIVNGMDCKLG
|
Venom prothrombin activator notanarin-D (vPA) (EC 3.4.21.6) (Venom coagulation factor Xa-like protease) [Cleaved into: Notanarin-D light chain; Notanarin-D heavy chain]
|
Notechis scutatus niger (Peninsula tiger snake) (Notechis ater niger)
| 1,027,870 | 20 | 2,209 |
Blood coagulation cascade activating toxin;Calcium;Direct protein sequencing;Disulfide bond;EGF-like domain;Gamma-carboxyglutamic acid;Hemostasis impairing toxin;Hydrolase;Protease;Prothrombin activator;Secreted;Toxin
|
GO:0004252; GO:0005576; GO:0006508; GO:0016504; GO:0090729
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12403650}.
| null | null | null | null | null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Hydrophiinae (subfamily), Notechis (genus), Notechis scutatus (species)
| null | true |
Notechis scutatus
| 12 |
row_1407
| false | null |
3,941 |
P25687
|
AVITGACERDLQCGKGTCCAVSLWIKSVRVCTPVGTSGEDCHPASHKIPFSGQRMHHTCPCAPNLACVQTSPKKFKCLSKS
|
Toxin MIT1 (MIT 1) (Black mamba intestinal toxin 1) (Black mamba venom protein A)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 81 | 8,604 |
3D-structure;Direct protein sequencing;Disulfide bond;G-protein coupled receptor impairing toxin;Secreted;Toxin
|
GO:0001935; GO:0005576; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10567694}.
| null | null |
PF06607;
|
IPR009523;IPR023569;
|
1IMT;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 0 |
row_3786
| false | null |
186 |
P00981
|
SGHLLLLLGLLTLWAELTPVSGAAKYCKLPLRIGPCKRKIPSFYYKWKAKQCLPFDYSGCGGNANRFKTIEECRRTCVG
|
Kunitz-type serine protease inhibitor homolog dendrotoxin K (DTX-K) (Venom basic protease inhibitor K)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 79 | 8,852 |
3D-structure;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Potassium channel impairing toxin;Secreted;Signal;Toxin;Voltage-gated potassium channel impairing toxin
|
GO:0004867; GO:0005615; GO:0015459; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8504088, ECO:0000269|PubMed:857902}.
|
SIGNAL <1..?
| null |
PF00014;
|
IPR002223;IPR036880;IPR020901;IPR050098;
|
1DTK;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 1 |
row_173
| false | null |
314 |
P0DKR6
|
MKTLLLTLLVVTIVCLDLGYSLKCYQHGKVVTCHRDMKFCYHNTGMPFRNLKLILQGCSSSCSETENNKCCSTDRCNK
|
Mambalgin-1 (Mamb-1) (Pi-Dp1)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 78 | 8,853 |
3D-structure;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Pharmaceutical;Proton-gated sodium channel impairing toxin;Secreted;Signal;Toxin
|
GO:0005576; GO:0090729; GO:0099106
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23034652}.
|
SIGNAL 1..21; /evidence="ECO:0000269|PubMed:23034652"
| null |
PF21947;
|
IPR003571;IPR045860;IPR054131;
|
2MJY;5DO6;5DU1;5DZ5;7CFT;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 2 |
row_296
| false | null |
974 |
C0HJD7
|
RTCNKTFSDQSKICPPGENICYTKTWCDAFCSQRGKRVELGCAATCPKVKAGVEIKCCSTDNCNKFQFGKPR
|
Alpha-elapitoxin-Dpp2d (Alpha-EPTX-Dpp2d)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 72 | 8,002 |
3D-structure;Acetylcholine receptor inhibiting toxin;Amidation;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Postsynaptic neurotoxin;Secreted;Toxin
|
GO:0005576; GO:0030550; GO:0090729; GO:0099106
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24867092}.
| null | null |
PF21947;
|
IPR003571;IPR045860;IPR018354;IPR054131;
|
4LFT;8DA0;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 3 |
row_919
| false | null |
4,201 |
P80494
|
LTCVTSKSIFGITTENCPDGQNLCFKKWYYLNHRYSDITWGCAATCPKPTNVRETIHCCETDKCNE
|
Muscarinic toxin alpha (MT-alpha)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 66 | 7,554 |
3D-structure;Direct protein sequencing;Disulfide bond;G-protein coupled receptor impairing toxin;Neurotoxin;Postsynaptic neurotoxin;Secreted;Toxin
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8536706}.
| null | null |
PF21947;
|
IPR003571;IPR045860;IPR018354;IPR054131;
|
7ULS;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 4 |
row_4036
| false | null |
3,931 |
P25518
|
LTCVTSKSIFGITTEDCPDGQNLCFKRRHYVVPKIYDITRGCVATCPIPENYDSIHCCKTEKCNN
|
Adrenergic toxin rho-elapitoxin-Dp1b (rho-EPTX-Dp1b) (Muscarinic toxin CM-3) (Protein CM-3)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 65 | 7,344 |
Direct protein sequencing;Disulfide bond;G-protein coupled receptor impairing toxin;Neurotoxin;Postsynaptic neurotoxin;Secreted;Toxin
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:4029488}.
| null | null |
PF21947;
|
IPR003572;IPR003571;IPR045860;IPR018354;IPR054131;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 5 |
row_3776
| false | null |
6,740 |
P25681
|
TICYSHTTTSRAILKDCGENSCYRKSRRHPPKMVLGRGCGCPPGDDYLEVKCCTSPDKCNY
|
Acetylcholinesterase toxin C (Fasciculin)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 61 | 6,817 |
Direct protein sequencing;Disulfide bond;Secreted;Toxin
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 2 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
| null | null |
PF21947;
|
IPR003571;IPR045860;IPR018354;IPR054131;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 6 |
row_6488
| false | null |
1,321 |
P00979
|
QPLRKLCILHRNPGRCYQKIPAFYYNQKKKQCEGFTWSGCGGNSNRFKTIEECRRTCIRK
|
Kunitz-type serine protease inhibitor homolog dendrotoxin I (DTX-I) (Dendrotoxin-1) (Venom basic protease inhibitor 1)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 60 | 7,155 |
3D-structure;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Potassium channel impairing toxin;Secreted;Toxin;Voltage-gated potassium channel impairing toxin
|
GO:0004867; GO:0005615; GO:0015459; GO:0090729
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted.
| null | null |
PF00014;
|
IPR002223;IPR036880;IPR020901;IPR050098;
|
1DEM;1DEN;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 7 |
row_1262
| false | null |
3,051 |
P01414
|
RICYSHKASLPRATKTCVENTCYKMFIRTHRQYISERGCGCPTAMWPYQTECCKGDRCNK
|
Toxin FS-2 (FS2)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 60 | 7,026 |
3D-structure;Calcium channel impairing toxin;Cardiotoxin;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Secreted;Toxin;Voltage-gated calcium channel impairing toxin
|
GO:0005246; GO:0005576; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:880951}.
| null | null |
PF21947;
|
IPR003571;IPR045860;IPR018354;IPR054131;
|
1TFS;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 8 |
row_2949
| false | null |
3,052 |
P01416
|
RICYNHQSTTRATTKSCEENSCYKKYWRDHRGTIIERGCGCPKVKPGVGIHCCQSDKCNY
|
Short neurotoxin 1 (Neurotoxin alpha)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 60 | 6,915 |
3D-structure;Acetylcholine receptor inhibiting toxin;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Postsynaptic neurotoxin;Secreted;Toxin
|
GO:0005576; GO:0030550; GO:0090729; GO:0099106
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:5033401}.
| null | null |
PF21947;
|
IPR003571;IPR045860;IPR018354;IPR054131;
|
1NTX;8V13;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 9 |
row_2950
| false | null |
3,033 |
P00984
|
LQHRTFCKLPAEPGPCKASIPAFYYNWAAKKCQLFHYGGCKGNANRFSTIEKCRHACVG
|
Kunitz-type serine protease inhibitor dendrotoxin E (DTX-E) (Protein E) (Venom basic protease inhibitor E)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 59 | 6,620 |
Copper;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Potassium channel impairing toxin;Protease inhibitor;Secreted;Serine protease inhibitor;Toxin;Voltage-gated potassium channel impairing toxin
|
GO:0004867; GO:0005576; GO:0015459; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:668688}.
| null | null |
PF00014;
|
IPR002223;IPR036880;IPR020901;IPR050098;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 10 |
row_2932
| false | null |
1,322 |
P00983
|
RPYACELIVAAGPCMFFISAFYYSKGANKCYPFTYSGCRGNANRFKTIEECRRTCVV
|
Mambaquaretin-7 (MQ7) (Kunitz-type serine protease inhibitor homolog dendrotoxin B) (DTX-B) (Mambaquaretin-8) (MQ8) (Protein B) (Upsilon-Dp2b) (Upsilon-Dp2c) (Venom basic protease inhibitor B)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 57 | 6,476 |
Direct protein sequencing;Disulfide bond;G-protein coupled receptor impairing toxin;Secreted;Toxin
|
GO:0004867; GO:0005615; GO:0090729
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7309000}.
| null | null |
PF00014;
|
IPR002223;IPR036880;IPR020901;IPR050098;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 11 |
row_1263
| false | null |
1,504 |
P0DKS3
|
LKCFQHGKVVTCHRDMKFCYHNTGMPFRNLKLILQGCSSSCSETENNKCCSTDRCNK
|
Mambalgin-2 (Ma-2) (Mamb-2) (Pi-Dp2)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 57 | 6,547 |
3D-structure;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Pharmaceutical;Proton-gated sodium channel impairing toxin;Secreted;Toxin
|
GO:0005576; GO:0090729; GO:0099106
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23034652}.
| null | null |
PF21947;
|
IPR003571;IPR045860;IPR054131;
|
2MFA;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 12 |
row_1441
| false | null |
2,406 |
A0A4P1LYC9
|
TICHIQISKTHGILKTCEENSCYKMSVRGWIIGRGCGCPSAVRPRQVQCCTSDKCNY
|
Dendroaspis polylepis MT9 (Three-finger toxin) (3FTx)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 57 | 6,364 |
3D-structure;Direct protein sequencing;Disulfide bond;G-protein coupled acetylcholine receptor impairing toxin;G-protein coupled receptor impairing toxin;Neurotoxin;Postsynaptic neurotoxin;Secreted;Toxin
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
| null | null |
PF21947;
|
IPR003571;IPR045860;IPR018354;IPR054131;
|
6R5M;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 13 |
row_2319
| false | null |
2,662 |
C0HLA6
|
RPSFCNLPVKPGPCNGFFSAFYYSQKKNKCHSFTYGGCKGNANRFSTIEECRRTCVG
|
Mambaquaretin-3 (MQ3) (Upsilon-Dp2a)
|
Dendroaspis polylepis polylepis (Black mamba)
| 8,620 | 57 | 6,405 |
Direct protein sequencing;Disulfide bond;G-protein coupled receptor impairing toxin;Secreted;Toxin
|
GO:0004867; GO:0005615; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:35122240}.
| null | null |
PF00014;
|
IPR002223;IPR036880;IPR020901;IPR050098;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Dendroaspis (genus), Dendroaspis polylepis (species)
| null | true |
Dendroaspis polylepis
| 14 |
row_2572
| false | null |
1,665 |
P19855
|
MKLLLLLIVSASMLIESLVNADGYIRKRDGCKLSCLFGNEGCNKECKSYGGSYGYCWTWGLACWCEGLPDDKTWKSETNTCG
|
Beta-insect depressant toxin LqqIT2 (Insect toxin 2)
|
Leiurus quinquestriatus quinquestriatus (Egyptian scorpion) (Deathstalker scorpion)
| 6,885 | 82 | 9,100 |
Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Secreted;Signal;Toxin;Voltage-gated sodium channel impairing toxin
|
GO:0005576; GO:0006952; GO:0019871; GO:0090729
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2029523, ECO:0000269|PubMed:2311768, ECO:0000269|PubMed:8431601}.
|
SIGNAL 1..21; /evidence="ECO:0000269|PubMed:2029523, ECO:0000269|PubMed:2311768, ECO:0000269|PubMed:8431601"
| null |
PF00537;
|
IPR044062;IPR003614;IPR036574;IPR018218;IPR002061;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Ecdysozoa (clade), Panarthropoda (clade), Arthropoda (phylum), Chelicerata (subphylum), Arachnida (class), Scorpiones (order), Buthida (parvorder), Buthoidea (superfamily), Buthidae (family), Leiurus (genus), Leiurus quinquestriatus (species)
| null | true |
Leiurus quinquestriatus
| 0 |
row_1594
| false | null |
3,889 |
P19856
|
KKNGYAVDSSGKAPECLLSNYCYNECTKVHYADKGYCCLLSCYCVGLSDDKKVLEISDARKKYCDFVTIN
|
Beta-insect excitatory toxin LqqIT1 (Insect toxin 1) (LqqIT1')
|
Leiurus quinquestriatus quinquestriatus (Egyptian scorpion) (Deathstalker scorpion)
| 6,885 | 70 | 7,849 |
Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Secreted;Toxin;Voltage-gated sodium channel impairing toxin
|
GO:0005576; GO:0006952; GO:0019871; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2311768}.
| null | null |
PF00537;
|
IPR044062;IPR003614;IPR036574;IPR002061;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Ecdysozoa (clade), Panarthropoda (clade), Arthropoda (phylum), Chelicerata (subphylum), Arachnida (class), Scorpiones (order), Buthida (parvorder), Buthoidea (superfamily), Buthidae (family), Leiurus (genus), Leiurus quinquestriatus (species)
| null | true |
Leiurus quinquestriatus
| 1 |
row_3734
| false | null |
196 |
P01489
|
GVRDAYIADDKNCVYTCGSNSYCNTECTKNGAESGYCQWLGKYGNACWCIKLPDKVPIRIPGKCR
|
Alpha-toxin Lqq4 (Lqq IV) (LqqIV) (Toxin IV)
|
Leiurus quinquestriatus quinquestriatus (Egyptian scorpion) (Deathstalker scorpion)
| 6,885 | 65 | 7,202 |
3D-structure;Amidation;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Secreted;Toxin;Voltage-gated sodium channel impairing toxin
|
GO:0005576; GO:0006952; GO:0019871; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:37501371, ECO:0000269|Ref.1}.
| null | null |
PF00537;
|
IPR044062;IPR003614;IPR036574;IPR018218;IPR002061;
|
8BO0;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Ecdysozoa (clade), Panarthropoda (clade), Arthropoda (phylum), Chelicerata (subphylum), Arachnida (class), Scorpiones (order), Buthida (parvorder), Buthoidea (superfamily), Buthidae (family), Leiurus (genus), Leiurus quinquestriatus (species)
| null | true |
Leiurus quinquestriatus
| 2 |
row_183
| false | null |
1,338 |
P01481
|
LKDGYIVDDKNCTFFCGRNAYCNDECKKKGGESGYCQWASPYGNACWCYKLPDRVSIKEKGRCN
|
Alpha-mammal toxin Lqq5 (Lqq V) (LqqV) (Neurotoxin V)
|
Leiurus quinquestriatus quinquestriatus (Egyptian scorpion) (Deathstalker scorpion)
| 6,885 | 64 | 7,301 |
Amidation;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Secreted;Toxin;Voltage-gated sodium channel impairing toxin
|
GO:0005576; GO:0006952; GO:0019871; GO:0090729
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:658402}.
| null | null |
PF00537;
|
IPR044062;IPR003614;IPR036574;IPR018218;IPR002061;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Ecdysozoa (clade), Panarthropoda (clade), Arthropoda (phylum), Chelicerata (subphylum), Arachnida (class), Scorpiones (order), Buthida (parvorder), Buthoidea (superfamily), Buthidae (family), Leiurus (genus), Leiurus quinquestriatus (species)
| null | true |
Leiurus quinquestriatus
| 3 |
row_1279
| false | null |
3,094 |
P01487
|
VRDAYIAKNYNCVYECFRDSYCNDLCTKNGASSGYCQWAGKYGNACWCYALPDNVPIRVPGKCH
|
Alpha-insect toxin Lqq3 (Lqq III) (LqqIII)
|
Leiurus quinquestriatus quinquestriatus (Egyptian scorpion) (Deathstalker scorpion)
| 6,885 | 64 | 7,240 |
3D-structure;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Secreted;Toxin;Voltage-gated sodium channel impairing toxin
|
GO:0005576; GO:0006952; GO:0019871; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted.
| null | null |
PF00537;
|
IPR044062;IPR003614;IPR036574;IPR018218;IPR002061;
|
1LQQ;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Ecdysozoa (clade), Panarthropoda (clade), Arthropoda (phylum), Chelicerata (subphylum), Arachnida (class), Scorpiones (order), Buthida (parvorder), Buthoidea (superfamily), Buthidae (family), Leiurus (genus), Leiurus quinquestriatus (species)
| null | true |
Leiurus quinquestriatus
| 4 |
row_2992
| false | null |
3,996 |
P45639
|
MCMPCFTTDHQMARKCDDCCGGKGRGKCYGPQCLCR
|
Chlorotoxin (CTX) (ClTx) (Tozuleristide)
|
Leiurus quinquestriatus quinquestriatus (Egyptian scorpion) (Deathstalker scorpion)
| 6,885 | 36 | 4,005 |
3D-structure;Chloride channel impairing toxin;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Knottin;Metalloenzyme inhibitor;Metalloprotease inhibitor;Neurotoxin;Protease inhibitor;Secreted;Toxin;Voltage-gated chloride channel impairing toxin
|
GO:0005576; GO:0017081; GO:0030414; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8383429}.
| null | null |
PF05294;
|
IPR036574;IPR007958;
|
1CHL;5L1C;6ATW;7SOH;7X41;7X43;7X44;7X4D;8C5G;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Ecdysozoa (clade), Panarthropoda (clade), Arthropoda (phylum), Chelicerata (subphylum), Arachnida (class), Scorpiones (order), Buthida (parvorder), Buthoidea (superfamily), Buthidae (family), Leiurus (genus), Leiurus quinquestriatus (species)
| null | true |
Leiurus quinquestriatus
| 5 |
row_3839
| false | null |
6,757 |
P45661
|
GLIDVRCYDSSQCE
|
Leiurutoxin-3 (Leiurutoxin III) (Potassium channel toxin alpha-KTx)
|
Leiurus quinquestriatus quinquestriatus (Egyptian scorpion) (Deathstalker scorpion)
| 6,885 | 14 | 1,588 |
Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Potassium channel impairing toxin;Secreted;Toxin
|
GO:0005576; GO:0015459; GO:0090729
|
Evidence at protein level
| 2 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1280139}.
| null | null | null | null | null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Ecdysozoa (clade), Panarthropoda (clade), Arthropoda (phylum), Chelicerata (subphylum), Arachnida (class), Scorpiones (order), Buthida (parvorder), Buthoidea (superfamily), Buthidae (family), Leiurus (genus), Leiurus quinquestriatus (species)
| null | true |
Leiurus quinquestriatus
| 6 |
row_6505
| false | null |
232 |
P09545
|
MPKLNRCAIAIFTILSAISSPTLLANINEPSGEAADIISQVADSHAIKYYNAADWQAEDNALPSLAELRDLVINQQKRVLVDFSQISDAEGQAEMQAQFRKAYGVGFANQFIVITEHKGELLFTPFDQAEEVDPQLLEAPRTARLLARSGFASPAPANSETNTLPHVAFYISVNRAISDEECTFNNSWLWKNEKGSRPFCKDANISLIYRVNLERSLQYGIVGSATPDAKIVRISLDDDSTGAGIHLNDQLGYRQFGASYTTLDAYFREWSTDAIAQDYRFVFNASNNKAQILKTFPVDNINEKFERKEVSGFELGVTGGVEVSGDGPKAKLEARASYTQSRWLTYNTQDYRIERNAKNAQAVSFTWNRQQYATAESLLNRSTDALWVNTYPVDVNRISPLSYASFVPKMDVIYKASATETGSTDFIIDSSVNIRPIYNGAYKHYYVVGAHQSYHGFEDTPRRRITKSASFTVDWDHPVFTGGRPVNLQLASFNNRCIQVDAQGRLAANTCDSQQSAQSFIYDQLGRYVSASNTKLCLDGEALDALQPCNQNLTQRWEWRKGTDELTNVYSGESLGHDKQTGELGLYASSNDAVSLRTITAYTDVFNAQESSPILGYTQGKMNQQRVGQDHRLYVRAGAAIDALGSASDLLVGGNGGSLSSVDLSGVKSITATSGDFQYGGQQLVALTFTYQDGRQQTVGSKAYVTNAHEDRFDLPAAAKITQLKIWSDDWLVKGVQFDLN
|
Hemolysin
|
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
| 243,277 | 741 | 81,962 |
3D-structure;Cytolysis;Direct protein sequencing;Disulfide bond;Hemolysis;Host cell membrane;Host membrane;Lectin;Membrane;Reference proteome;Secreted;Signal;Toxin;Transmembrane;Transmembrane beta strand;Virulence
|
GO:0005576; GO:0016020; GO:0020002; GO:0030246; GO:0042802; GO:0051715; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15978620}. Host cell membrane {ECO:0000269|PubMed:15978620}; Multi-pass membrane protein {ECO:0000269|PubMed:15978620}. Note=In the hemolytic biotype El Tor the 80 kDa hemolysin precursor is secreted as monomer. After binding to target membranes the protein assembles into a heptameric prepore complex. Proteolytic cleavage triggers a conformation change that is required for membrane insertion and pore formation.
|
SIGNAL 1..25; /evidence="ECO:0000269|PubMed:2174833"
| null |
PF16458;PF12563;PF07968;
|
IPR032496;IPR022220;IPR043080;IPR044883;IPR036404;IPR016183;IPR036435;IPR035992;IPR000772;
|
1XEZ;3O44;4GX7;7YL9;
|
cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Gammaproteobacteria (class), Vibrionales (order), Vibrionaceae (family), Vibrio (genus), Vibrio cholerae (species), Vibrio cholerae O1 (serogroup), Vibrio cholerae serotype O1 biovar El Tor (no rank)
|
hlyA VC_A0219
| true |
Vibrio cholerae
| 0 |
row_217
| false | null |
6,755 |
P38442
|
MSIFIHHGAPGSYKTSGALWLRLLPAIKSGRHIITNVRGLNLERMAKYLKMDVSDISIEFIDTDHPDGRLTMARFWHWARKDAFLFIDECGRIWPPRLTVTNLKALDTPPDLVAEDRPESFEVAFDMHRHHGWDICLTTPNIAKVHNMIREAAEIGYRHFNRATVGLGAKFTLTTHDAANSGQMDSHALTRQVKKIPSPIFKMYASTTTGKARDTMAGTALWKDRKILFLFGMVFLMFSYSFYGLHDNPIFTGGNDATIESEQSEPQSKATVGNAVGSKAVAPASFGFCIGRLCVQDGFVTVGDERYRLVDNLDIPYRGLWATGHHIYKDTLTVFFETESGSVPTELFASSYRYKVLPLPDFNHFVVFDTFAAQALWVEVKRGLPIKTENDKKGLNSIF
|
Zona occludens toxin (Zonular occludens toxin) (Zot)
|
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
| 243,277 | 399 | 44,903 |
Enterotoxin;Reference proteome;Toxin;Virulence
|
GO:0090729
|
Evidence at protein level
| 2 | null | null | null |
PF05707;
|
IPR027417;IPR008900;
| null |
cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Gammaproteobacteria (class), Vibrionales (order), Vibrionaceae (family), Vibrio (genus), Vibrio cholerae (species), Vibrio cholerae O1 (serogroup), Vibrio cholerae serotype O1 biovar El Tor (no rank)
|
zot VC_1458
| true |
Vibrio cholerae
| 1 |
row_6503
| false | null |
207 |
P01555
|
MVKIIFVFFIFLSSFSYANDDKLYRADSRPPDEIKQSGGLMPRGQSEYFDRGTQMNINLYDHARGTQTGFVRHDDGYVSTSISLRSAHLVGQTILSGHSTYYIYVIATAPNMFNVNDVLGAYSPHPDEQEVSALGGIPYSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAADGYGLAGFPPEHRAWREEPWIHHAPPGCGNAPRSSMSNTCDEKTQSLGVKFLDEYQSKVKRQIFSGYQSDIDTHNRIKDEL
|
Cholera enterotoxin subunit A (Cholera enterotoxin, A chain) [Cleaved into: Cholera enterotoxin subunit A1 (EC 2.4.2.-) (Cholera enterotoxin A1 chain) (Cholera enterotoxin alpha chain) (NAD(+)--diphthamide ADP-ribosyltransferase); Cholera enterotoxin subunit A2 (Cholera enterotoxin A2 chain) (Cholera enterotoxin gamma chain)]
|
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
| 243,277 | 258 | 29,336 |
3D-structure;Direct protein sequencing;Disulfide bond;Enterotoxin;Glycosyltransferase;NAD;Nucleotidyltransferase;Reference proteome;Signal;Toxin;Transferase;Virulence
|
GO:0005534; GO:0005615; GO:0008289; GO:0016757; GO:0016779; GO:0042531; GO:0042597; GO:0090729; GO:0141104; GO:1902494
|
Evidence at protein level
| 5 | null |
SIGNAL 1..18; /evidence="ECO:0000269|PubMed:7238869, ECO:0000269|PubMed:955672"
| null |
PF01375;
|
IPR001144;
|
1S5B;1S5C;1S5D;1S5E;1S5F;1XTC;2A5D;2A5F;2A5G;8OXS;8Q6I;8QRE;
|
cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Gammaproteobacteria (class), Vibrionales (order), Vibrionaceae (family), Vibrio (genus), Vibrio cholerae (species), Vibrio cholerae O1 (serogroup), Vibrio cholerae serotype O1 biovar El Tor (no rank)
|
ctxA toxA VC_1457
| true |
Vibrio cholerae
| 2 |
row_194
| false | null |
208 |
P01556
|
MIKLKFGVFFTVLLSSAYAHGTPQNITDLCAEYHNTQIYTLNDKIFSYTESLAGKREMAIITFKNGAIFQVEVPGSQHIDSQKKAIERMKDTLRIAYLTEAKVEKLCVWNNKTPHAIAAISMAN
|
Cholera enterotoxin subunit B (Cholera enterotoxin B chain) (Cholera enterotoxin gamma chain) (Choleragenoid)
|
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
| 243,277 | 124 | 13,957 |
3D-structure;Direct protein sequencing;Disulfide bond;Enterotoxin;Host cell membrane;Host membrane;Membrane;Reference proteome;Secreted;Signal;Toxin;Virulence
|
GO:0005534; GO:0005576; GO:0016020; GO:0020002; GO:0042531; GO:0042597; GO:0046812; GO:0090729; GO:1902494
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted. Host cell membrane {ECO:0000305}.
|
SIGNAL 1..21; /evidence="ECO:0000269|PubMed:903362, ECO:0000269|PubMed:903363"
| null |
PF01376;
|
IPR008992;IPR001835;
|
1CHP;1CHQ;1CT1;1FGB;1G8Z;1JR0;1MD2;1RCV;1RD9;1RDP;1RF2;1S5B;1S5C;1S5D;1S5E;1S5F;1XTC;2CHB;3CHB;3EFX;5ELC;5ELE;5ELF;5LZG;5LZJ;6HJD;6HMW;6HMY;6HSV;7LVB;8OXS;8Q6I;8QRE;9EWF;
|
cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Gammaproteobacteria (class), Vibrionales (order), Vibrionaceae (family), Vibrio (genus), Vibrio cholerae (species), Vibrio cholerae O1 (serogroup), Vibrio cholerae serotype O1 biovar El Tor (no rank)
|
ctxB toxB VC_1456
| true |
Vibrio cholerae
| 3 |
row_195
| false | null |
6,754 |
P38441
|
MLMMDTLYDWLIDGFTWLVIKLGIMWIESKIFVIQFFWEMSQKVIDMFTIYPLIQQAIDMLPPQYSGFLFFLGLDQALAIVLQALMTRFALRALNL
|
Accessory cholera enterotoxin (Ace)
|
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
| 243,277 | 96 | 11,347 |
Enterotoxin;Host cell membrane;Host membrane;Membrane;Reference proteome;Secreted;Toxin;Transmembrane;Transmembrane helix;Virulence
|
GO:0005576; GO:0016020; GO:0020002; GO:0090729
|
Predicted
| 2 |
SUBCELLULAR LOCATION: Secreted. Host cell membrane {ECO:0000305}.
| null |
TRANSMEM 76..96; /note="Helical"; /evidence="ECO:0000255"
|
PF10734;
|
IPR019670;
| null |
cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Gammaproteobacteria (class), Vibrionales (order), Vibrionaceae (family), Vibrio (genus), Vibrio cholerae (species), Vibrio cholerae O1 (serogroup), Vibrio cholerae serotype O1 biovar El Tor (no rank)
|
ace VC_1459
| true |
Vibrio cholerae
| 4 |
row_6502
| false | null |
212 |
P04512
|
MEKLTDLNYTLSVITLMNNTLHTILEDPGMAYFPYIASVLTGLFALNKASIPTMKIALKTSKCSYKVVKYCIVTIFNTLLKLAGYKEQITTKDEIEKQMDRVVKEMRRQLEMIDKLTTREIEQVELLKRIYDKLTVQTTGEIDMTKEINQKNVRTLEEWESGKNPYEPREVTAAM
|
Non-structural glycoprotein 4 (NSP4) (NCVP5) (NS28)
|
Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain Both))
| 37,137 | 175 | 20,267 |
3D-structure;Activation of host autophagy by virus;Calcium;Direct protein sequencing;Enterotoxin;Glycoprotein;Host endoplasmic reticulum;Host membrane;Host-virus interaction;Ion channel;Ion transport;Membrane;Metal-binding;Reference proteome;Secreted;Signal-anchor;Toxin;Transmembrane;Transmembrane helix;Transport;Viral ion channel;Virulence
|
GO:0005576; GO:0015267; GO:0016020; GO:0016032; GO:0034220; GO:0039520; GO:0044155; GO:0044169; GO:0046872; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Host rough endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P08434, ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Host membrane, host caveola {ECO:0000255|HAMAP-Rule:MF_04091, ECO:0000269|PubMed:17376898}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Secreted {ECO:0000255|HAMAP-Rule:MF_04091, ECO:0000269|PubMed:17035333}. Note=NSP4 also localizes in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus-infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain. {ECO:0000255|HAMAP-Rule:MF_04091}.
| null |
TRANSMEM 29..51; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255|HAMAP-Rule:MF_04091"
|
PF01452;
|
IPR002107;
|
1G1I;1G1J;2O1K;
|
Viruses (no rank), Riboviria (realm), Orthornavirae (kingdom), Duplornaviricota (phylum), Resentoviricetes (class), Reovirales (order), Sedoreoviridae (family), Rotavirus (genus), Rotavirus A (species), Simian rotavirus A (no rank), Simian rotavirus A/SA11 (no rank)
| null | true |
Rotavirus A
| 0 |
row_199
| false | null |
958 |
B3SRV6
|
MDKLADLNYTLSVITLMNDTLHSIIQDPGMAYFPYIASVLTVLFTLHKASIPTMKIALKTSKCSYKVIKYCIVTIINTLLKLAGYKEQVTTKDEIEQQMDRIVKEMRRQLEMIDKLTTREIEQVELLKRIHDNLITRSVDVIDMSKEFNQKNIKTLDEWESGKNPYEPSEVTASM
|
Non-structural glycoprotein 4 (NSP4) (NCVP5) (NS28)
|
Rotavirus A (strain RVA/Human/United States/P/1974/G3P1A[8]) (RV-A)
| 10,957 | 175 | 20,237 |
Activation of host autophagy by virus;Calcium;Enterotoxin;Glycoprotein;Host endoplasmic reticulum;Host membrane;Host-virus interaction;Ion channel;Ion transport;Membrane;Metal-binding;Secreted;Signal-anchor;Toxin;Transmembrane;Transmembrane helix;Transport;Viral ion channel;Virulence
|
GO:0005576; GO:0015267; GO:0016020; GO:0016032; GO:0034220; GO:0039520; GO:0044155; GO:0044169; GO:0046872; GO:0090729
|
Inferred from homology
| 4 |
SUBCELLULAR LOCATION: Host rough endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Host membrane, host caveola {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Secreted {ECO:0000255|HAMAP-Rule:MF_04091}. Note=NSP4 also localizes in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus-infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain. {ECO:0000255|HAMAP-Rule:MF_04091}.
| null |
TRANSMEM 29..51; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255|HAMAP-Rule:MF_04091"
|
PF01452;
|
IPR002107;
| null |
Viruses (no rank), Riboviria (realm), Orthornavirae (kingdom), Duplornaviricota (phylum), Resentoviricetes (class), Reovirales (order), Sedoreoviridae (family), Rotavirus (genus), Rotavirus A (species), Rotavirus G3 (no rank)
| null | true |
Rotavirus A
| 1 |
row_903
| false | null |
1,293 |
O11982
|
MEKLADLNYTLGVITLLNDTLHNILEEPGMVYFPYVASALTVLFTMHKASLPAMKLAMRTSQCSYRIIKRVVVTLINTLLRLGGYNDYLTDKDETEKQINRVVKELRQQLTMIEKLTTREIEQVELLKRIYDMMVVRHDREIDMSKETNQKAFNTLHDWGNDRNYDDNTDVIAPL
|
Non-structural glycoprotein 4 (NSP4) (NCVP5) (NS28)
|
Rotavirus A (isolate RVA/Mouse/Brazil/EHP/1981/G16P[20]) (RV-A)
| 578,840 | 175 | 20,413 |
Activation of host autophagy by virus;Calcium;Enterotoxin;Glycoprotein;Host endoplasmic reticulum;Host membrane;Host-virus interaction;Ion channel;Ion transport;Membrane;Metal-binding;Secreted;Signal-anchor;Toxin;Transmembrane;Transmembrane helix;Transport;Viral ion channel;Virulence
|
GO:0005576; GO:0015267; GO:0016020; GO:0016032; GO:0034220; GO:0039520; GO:0044155; GO:0044169; GO:0046872; GO:0090729
|
Evidence at transcript level
| 4 |
SUBCELLULAR LOCATION: Host rough endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Host membrane, host caveola {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Secreted {ECO:0000255|HAMAP-Rule:MF_04091}. Note=NSP4 also localizes in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus-infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain. {ECO:0000255|HAMAP-Rule:MF_04091}.
| null |
TRANSMEM 29..51; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255|HAMAP-Rule:MF_04091"
|
PF01452;
|
IPR002107;
| null |
Viruses (no rank), Riboviria (realm), Orthornavirae (kingdom), Duplornaviricota (phylum), Resentoviricetes (class), Reovirales (order), Sedoreoviridae (family), Rotavirus (genus), Rotavirus A (species), Rotavirus G16 (no rank)
| null | true |
Rotavirus A
| 2 |
row_1234
| false | null |
1,303 |
O56850
|
MEKLTDLNYTLSVITLMNDTLHTIMEDPGMAYFPYIASVLTVLFTLHKASIPTMKIALRTSRCSYKVIKYCIVSIFNTLLKLAGYKEQITTKDEIEKQMDRVVKEMRRQLEMIDKLTTREIEQVELLKRIHDMLIIKPVDKIDMSQEFNQRQFKTLNEWAEGENPYEPKEVTASL
|
Non-structural glycoprotein 4 (NSP4) (NCVP5) (NS28)
|
Rotavirus A (strain RVA/Human/Japan/AU-1/1982/G3P3[9]) (RV-A)
| 39,013 | 175 | 20,513 |
Activation of host autophagy by virus;Calcium;Enterotoxin;Glycoprotein;Host endoplasmic reticulum;Host membrane;Host-virus interaction;Ion channel;Ion transport;Membrane;Metal-binding;Secreted;Signal-anchor;Toxin;Transmembrane;Transmembrane helix;Transport;Viral ion channel;Virulence
|
GO:0005576; GO:0015267; GO:0016020; GO:0016032; GO:0034220; GO:0039520; GO:0044155; GO:0044169; GO:0046872; GO:0090729
|
Evidence at transcript level
| 4 |
SUBCELLULAR LOCATION: Host rough endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Host membrane, host caveola {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Secreted {ECO:0000255|HAMAP-Rule:MF_04091}. Note=NSP4 also localizes in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus-infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain. {ECO:0000255|HAMAP-Rule:MF_04091}.
| null |
TRANSMEM 29..51; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255|HAMAP-Rule:MF_04091"
|
PF01452;
|
IPR002107;
| null |
Viruses (no rank), Riboviria (realm), Orthornavirae (kingdom), Duplornaviricota (phylum), Resentoviricetes (class), Reovirales (order), Sedoreoviridae (family), Rotavirus (genus), Rotavirus A (species), Rotavirus G3 (no rank)
| null | true |
Rotavirus A
| 3 |
row_1244
| false | null |
1,694 |
P30031
|
MEKLTVLNYTLNVITLMNSTLHTILEDPGMAYFPYIASVLTVLFTLHRASIPTMKIALKTSKCSYKVVKYCIVTIFNTLLKLADYKEQITTKDEIEKQMDRVAKEMRRQLEMIDKLTTREIEQVKLLKRIYDKLMVRATDGIDMTKEINQKNVKTLEEWKSGKNPYEPKEVTAAM
|
Non-structural glycoprotein 4 (NSP4) (NCVP5) (NS28)
|
Rotavirus A (isolate RVA/Human/United Kingdom/A64/1987/G10P11[14]) (RV-A)
| 578,827 | 175 | 20,360 |
Activation of host autophagy by virus;Calcium;Enterotoxin;Glycoprotein;Host endoplasmic reticulum;Host membrane;Host-virus interaction;Ion channel;Ion transport;Membrane;Metal-binding;Secreted;Signal-anchor;Toxin;Transmembrane;Transmembrane helix;Transport;Viral ion channel;Virulence
|
GO:0005576; GO:0015267; GO:0016020; GO:0016032; GO:0034220; GO:0039520; GO:0044155; GO:0044169; GO:0046872; GO:0090729
|
Inferred from homology
| 4 |
SUBCELLULAR LOCATION: Host rough endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Host membrane, host caveola {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Secreted {ECO:0000255|HAMAP-Rule:MF_04091}. Note=NSP4 also localizes in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus-infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain. {ECO:0000255|HAMAP-Rule:MF_04091}.
| null |
TRANSMEM 29..51; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255|HAMAP-Rule:MF_04091"
|
PF01452;
|
IPR002107;
| null |
Viruses (no rank), Riboviria (realm), Orthornavirae (kingdom), Duplornaviricota (phylum), Resentoviricetes (class), Reovirales (order), Sedoreoviridae (family), Rotavirus (genus), Rotavirus A (species), Rotavirus G10 (no rank), Rotavirus G10P11 (no rank)
| null | true |
Rotavirus A
| 4 |
row_1623
| false | null |
2,034 |
Q3ZK64
|
MDKLTDLNYTLSVITLMNSTLHKILEDPGMAYFPYIASVLTVLFTLHKASIPTMKIALKTSRCSYKVIKYCIVTIFNTLLKLAGYKEQITTKDEIEKQMDRVVREMRRQLEMIDKLTTREIEQVELLRRIYDRLTVQKTDEIDMSKEINQKNVRTLDEWENGKNPYEPSEVTASL
|
Non-structural glycoprotein 4 (NSP4) (NCVP5) (NS28)
|
Rotavirus A (isolate RVA/Human/Belgium/B4106/2000/G3P11[14]) (RV-A) (Rotavirus A (isolate B4106))
| 578,843 | 175 | 20,487 |
Activation of host autophagy by virus;Calcium;Enterotoxin;Glycoprotein;Host endoplasmic reticulum;Host membrane;Host-virus interaction;Ion channel;Ion transport;Membrane;Metal-binding;Secreted;Signal-anchor;Toxin;Transmembrane;Transmembrane helix;Transport;Viral ion channel;Virulence
|
GO:0005576; GO:0015267; GO:0016020; GO:0016032; GO:0034220; GO:0039520; GO:0044155; GO:0044169; GO:0046872; GO:0090729
|
Inferred from homology
| 4 |
SUBCELLULAR LOCATION: Host rough endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Host membrane, host caveola {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Secreted {ECO:0000255|HAMAP-Rule:MF_04091}. Note=NSP4 also localizes in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus-infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain. {ECO:0000255|HAMAP-Rule:MF_04091}.
| null |
TRANSMEM 29..51; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255|HAMAP-Rule:MF_04091"
|
PF01452;
|
IPR002107;
| null |
Viruses (no rank), Riboviria (realm), Orthornavirae (kingdom), Duplornaviricota (phylum), Resentoviricetes (class), Reovirales (order), Sedoreoviridae (family), Rotavirus (genus), Rotavirus A (species), Rotavirus G3 (no rank)
| null | true |
Rotavirus A
| 5 |
row_1952
| false | null |
2,280 |
Q9PYC8
|
MEKLTDLNYTLSVITLMNSTLHTILEDPGMAYFPYIASVLTVLFTLHKASIPTMKIALKTSKCSYKVVKYCIVTIFNTLLKLAGYKEQITTKDEIEKQMERVVKEMRRHFKMIDKLTTREIEQVGLLKRIHDKLDIRAVDEIDMTKEINQKNVRTLEEWEWGKNPYEPKEVTAAM
|
Non-structural glycoprotein 4 (NSP4) (NCVP5) (NS28)
|
Rotavirus A (isolate RVA/Cow/United States/B223/1983/G10P8[11]) (RV-A)
| 1,835,656 | 175 | 20,446 |
Activation of host autophagy by virus;Calcium;Enterotoxin;Glycoprotein;Host endoplasmic reticulum;Host membrane;Host-virus interaction;Ion channel;Ion transport;Membrane;Metal-binding;Secreted;Signal-anchor;Toxin;Transmembrane;Transmembrane helix;Transport;Viral ion channel;Virulence
|
GO:0005576; GO:0015267; GO:0016020; GO:0016032; GO:0034220; GO:0039520; GO:0044155; GO:0044169; GO:0046872; GO:0090729
|
Inferred from homology
| 4 |
SUBCELLULAR LOCATION: Host rough endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Host membrane, host caveola {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Secreted {ECO:0000255|HAMAP-Rule:MF_04091}. Note=NSP4 also localizes in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus-infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain. {ECO:0000255|HAMAP-Rule:MF_04091}.
| null |
TRANSMEM 29..51; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255|HAMAP-Rule:MF_04091"
|
PF01452;
|
IPR002107;
| null |
Viruses (no rank), Riboviria (realm), Orthornavirae (kingdom), Duplornaviricota (phylum), Resentoviricetes (class), Reovirales (order), Sedoreoviridae (family), Rotavirus (genus), Rotavirus A (species), Rotavirus G10 (no rank), Rotavirus G10P11 (no rank)
| null | true |
Rotavirus A
| 6 |
row_2196
| false | null |
2,295 |
Q9WAI7
|
MDKLADLNYTLSVVTLMNDTLHSIIQDPGMAYFPYVASVLTVLFALHKASIPTMKMALKTSKCSYKVIKYCIVPIINTLFKLAGFQEPITTKDEIEQPMDGIVKEIRRPLEMIDKLTTPEIEQVELLKSLHDHLITRPVDVIDMSKEFNQKNIKTLDEWDSGKNPYEPSEVTASM
|
Non-structural glycoprotein 4 (NSP4) (NCVP5) (NS28)
|
Rotavirus A (strain RVA/Human/Japan/MO/1982/G3P1A[8]) (RV-A)
| 10,956 | 175 | 19,905 |
Activation of host autophagy by virus;Calcium;Enterotoxin;Glycoprotein;Host endoplasmic reticulum;Host membrane;Host-virus interaction;Ion channel;Ion transport;Membrane;Metal-binding;Secreted;Signal-anchor;Toxin;Transmembrane;Transmembrane helix;Transport;Viral ion channel;Virulence
|
GO:0005576; GO:0015267; GO:0016020; GO:0016032; GO:0034220; GO:0039520; GO:0044155; GO:0044169; GO:0046872; GO:0090729
|
Inferred from homology
| 4 |
SUBCELLULAR LOCATION: Host rough endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Host membrane, host caveola {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Secreted {ECO:0000255|HAMAP-Rule:MF_04091}. Note=NSP4 also localizes in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus-infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain. {ECO:0000255|HAMAP-Rule:MF_04091}.
| null |
TRANSMEM 29..51; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255|HAMAP-Rule:MF_04091"
|
PF01452;
|
IPR002107;
| null |
Viruses (no rank), Riboviria (realm), Orthornavirae (kingdom), Duplornaviricota (phylum), Resentoviricetes (class), Reovirales (order), Sedoreoviridae (family), Rotavirus (genus), Rotavirus A (species), Rotavirus G1 (no rank)
| null | true |
Rotavirus A
| 7 |
row_2211
| false | null |
2,187 |
Q8V790
|
MENATTINETLVEEVYNMTMSYFEHNVIIMKYFPFLASILTIAFTAWKMGKSTFKVTKTVAGSGFKVVRVIVITIFNCIMRLFGSKTEIVSDDRLDALASKILAQINNQVKVIEQLTKRELEQVKLLADIYEMLKFKKDEVDMSFETNKKEYEKWVKDPYQPTRAVSLD
|
Non-structural glycoprotein 4 (NSP4) (NCVP5) (NS28)
|
Rotavirus A (strain RVA/Turkey/Ireland/Ty-1/1978/G7P[17]) (RV-A)
| 12,584 | 169 | 19,572 |
Activation of host autophagy by virus;Calcium;Enterotoxin;Glycoprotein;Host endoplasmic reticulum;Host membrane;Host-virus interaction;Ion channel;Ion transport;Membrane;Metal-binding;Secreted;Signal-anchor;Toxin;Transmembrane;Transmembrane helix;Transport;Viral ion channel;Virulence
|
GO:0005576; GO:0015267; GO:0016020; GO:0016032; GO:0034220; GO:0039520; GO:0044155; GO:0044169; GO:0046872; GO:0090729
|
Inferred from homology
| 4 |
SUBCELLULAR LOCATION: Host rough endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Host membrane, host caveola {ECO:0000255|HAMAP-Rule:MF_04091}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_04091}. Secreted {ECO:0000255|HAMAP-Rule:MF_04091}. Note=NSP4 also localizes in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus-infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain. {ECO:0000255|HAMAP-Rule:MF_04091}.
| null |
TRANSMEM 29..51; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255|HAMAP-Rule:MF_04091"
|
PF01452;
|
IPR002107;
| null |
Viruses (no rank), Riboviria (realm), Orthornavirae (kingdom), Duplornaviricota (phylum), Resentoviricetes (class), Reovirales (order), Sedoreoviridae (family), Rotavirus (genus), Rotavirus A (species), Avian rotavirus A (no rank)
| null | true |
Rotavirus A
| 8 |
row_2103
| false | null |
215 |
P04977
|
MRCTRAIRQTARTGWLTWLAILAVTAPVTSPAWADDPPATVYRYDSRPPEDVFQNGFTAWGNNDNVLDHLTGRSCQVGSSNSAFVSTSSSRRYTEVYLEHRMQEAVEAERAGRGTGHFIGYIYEVRADNNFYGAASSYFEYVDTYGDNAGRILAGALATYQSEYLAHRRIPPENIRRVTRVYHNGITGETTTTEYSNARYVSQQTRANPNPYTSRRSVASIVGTLVRMAPVIGACMARQAESSEAMAAWSERAGEAMVLVYYESIAYSF
|
Pertussis toxin subunit 1 (PTX S1) (Islet-activating protein S1) (IAP S1) (NAD-dependent ADP-ribosyltransferase) (EC 2.4.2.-)
|
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
| 257,313 | 269 | 29,974 |
3D-structure;Direct protein sequencing;Disulfide bond;Glycosyltransferase;NAD;Nucleotidyltransferase;Pharmaceutical;Reference proteome;Secreted;Signal;Toxin;Transferase;Virulence;Whooping cough
|
GO:0003950; GO:0005576; GO:0016779; GO:0090729; GO:0141104
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11854200}. Note=The individual chains are secreted by a sec-dependent mechanism into the periplasm. Then, S1 associates with the outer membrane before it joins with the B subunit to form the secretion-competent holotoxin. The type IV secretion system ptl mediates secretion of assembled toxin through the outer membrane.
|
SIGNAL 1..34
| null |
PF02917;
|
IPR003898;
|
1BCP;1PRT;1PTO;6RO0;7SKI;7SKK;7SKY;7SNE;7U6Z;
|
cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Betaproteobacteria (class), Burkholderiales (order), Alcaligenaceae (family), Bordetella (genus), Bordetella pertussis (species)
|
ptxA BP3783
| true |
Bordetella pertussis
| 0 |
row_201
| false | null |
3,124 |
P04979
|
MLINNKKLLHHILPILVLALLGMRTAQAVAPGIVIPPKALFTQQGGAYGRCPNGTRALTVAELRGNAELQTYLRQITPGWSIYGLYDGTYLGQAYGGIIKDAPPGAGFIYRETFCITTIYKTGQPAADHYYSKVTATRLLASTNSRLCAVFVRDGQSVIGACASPYEGRYRDMYDALRRLLYMIYMSGLAVRVHVSKEEQYYDYEDATFQTYALTGISLCNPAASIC
|
Pertussis toxin subunit 3 (PTX S3) (Islet-activating protein S3) (IAP S3)
|
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
| 257,313 | 227 | 24,988 |
3D-structure;Disulfide bond;Host cell membrane;Host membrane;Membrane;Reference proteome;Secreted;Signal;Toxin;Virulence;Whooping cough
|
GO:0005576; GO:0016020; GO:0020002; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted. Host cell membrane {ECO:0000305}.
|
SIGNAL 1..28
| null |
PF03440;PF02918;
|
IPR005138;IPR037015;IPR016187;IPR008992;IPR003899;IPR020063;
|
1BCP;1PRT;1PTO;6RO0;
|
cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Betaproteobacteria (class), Burkholderiales (order), Alcaligenaceae (family), Bordetella (genus), Bordetella pertussis (species)
|
ptxC BP3787
| true |
Bordetella pertussis
| 1 |
row_3022
| false | null |
1,355 |
P04978
|
MPIDRKTLCHLLSVLPLALLGSHVARASTPGIVIPPQEQITQHGGPYGRCANKTRALTVAELRGSGDLQEYLRHVTRGWSIFALYDGTYLGGEYGGVIKDGTPGGAFDLKTTFCIMTTRNTGQPATDHYYSNVTATRLLSSTNSRLCAVFVRSGQPVIGACTSPYDGKYWSMYSRLRKMLYLIYVAGISVRVHVSKEEQYYDYEDATFETYALTGISICNPGSSLC
|
Pertussis toxin subunit 2 (PTX S2) (Islet-activating protein S2) (IAP S2)
|
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
| 257,313 | 226 | 24,799 |
3D-structure;Disulfide bond;Host cell membrane;Host membrane;Membrane;Reference proteome;Secreted;Signal;Toxin;Virulence;Whooping cough
|
GO:0005576; GO:0016020; GO:0020002; GO:0090729; GO:0141071
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted. Host cell membrane {ECO:0000305}.
|
SIGNAL 1..27
| null |
PF03440;PF02918;
|
IPR005138;IPR037015;IPR016187;IPR008992;IPR003899;IPR020063;
|
1BCP;1PRT;1PTO;6RO0;
|
cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Betaproteobacteria (class), Burkholderiales (order), Alcaligenaceae (family), Bordetella (genus), Bordetella pertussis (species)
|
ptxB BP3784
| true |
Bordetella pertussis
| 2 |
row_1296
| false | null |
3,161 |
P0A3R5
|
MLRRFPTRTTAPGQGGARRSRVRALAWLLASGAMTHLSPALADVPYVLVKTNMVVTSVAMKPYEVTPTRMLVCGIAAKLGAAASSPDAHVPFCFGKDLKRPGSSPMEVMLRAVFMQQRPLRMFLGPKQLTFEGKPALELIRMVECSGKQDCP
|
Pertussis toxin subunit 4 (PTX S4) (Islet-activating protein S4) (IAP S4)
|
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
| 257,313 | 152 | 16,544 |
3D-structure;Disulfide bond;Host cell membrane;Host membrane;Membrane;Reference proteome;Secreted;Signal;Toxin;Virulence;Whooping cough
|
GO:0005576; GO:0016020; GO:0020002; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted. Host cell membrane {ECO:0000305}.
|
SIGNAL 1..42
| null |
PF09275;
|
IPR008992;IPR015355;
|
1BCP;1PRT;1PTO;6RO0;
|
cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Betaproteobacteria (class), Burkholderiales (order), Alcaligenaceae (family), Bordetella (genus), Bordetella pertussis (species)
|
ptxD BP3785
| true |
Bordetella pertussis
| 3 |
row_3048
| false | null |
3,125 |
P04981
|
MQRQAGLPLKANPMHTIASILLSVLGIYSPADVAGLPTHLYKNFTVQELALKLKGKNQEFCLTAFMSGRSLVRACLSDAGHEHDTWFDTMLGFAISAYALKSRIALTVEDSPYPGTPGDLLELQICPLNGYCE
|
Pertussis toxin subunit 5 (PTX S5) (Islet-activating protein S5) (IAP S5)
|
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
| 257,313 | 133 | 14,500 |
3D-structure;Disulfide bond;Host cell membrane;Host membrane;Membrane;Reference proteome;Secreted;Signal;Toxin;Virulence;Whooping cough
|
GO:0005576; GO:0016020; GO:0020002; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted. Host cell membrane {ECO:0000305}.
|
SIGNAL 1..34
| null |
PF09276;
|
IPR008992;IPR015356;
|
1BCP;1PRT;1PTO;6RO0;
|
cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Betaproteobacteria (class), Burkholderiales (order), Alcaligenaceae (family), Bordetella (genus), Bordetella pertussis (species)
|
ptxE BP3786
| true |
Bordetella pertussis
| 4 |
row_3023
| false | null |
231 |
P09385
|
MKCILFKWVLCLLLGFSSVSYSREFTIDFSTQQSYVSSLNSIRTEISTPLEHISQGTTSVSVINHTPPGSYFAVDIRGLDVYQARFDHLRLIIEQNNLYVAGFVNTATNTFYRFSDFTHISVPGVTTVSMTTDSSYTTLQRVAALERSGMQISRHSLVSSYLALMEFSGNTMTRDASRAVLRFVTVTAEALRFRQIQREFRQALSETAPVYTMTPGDVDLTLNWGRISNVLPEYRGEDGVRVGRISFNNISAILGTVAVILNCHHQGARSVRAVNEESQPECQITGDRPVIKINNTLWESNTAAAFLNRKSQFLYTTGK
|
Shiga-like toxin 2 subunit A (SLT-2 A subunit) (SLT-2a) (SLT-IIa) (EC 3.2.2.22) (Verocytotoxin 2 subunit A) (Verotoxin 2 subunit A) (rRNA N-glycosidase 2)
|
Escherichia phage 933W (Bacteriophage 933W)
| 10,730 | 319 | 35,714 |
3D-structure;Disulfide bond;Hydrolase;Modulation of host virulence by virus;Protein synthesis inhibitor;Reference proteome;Secreted;Signal;Toxin;Viral exotoxin;Virulence
|
GO:0005576; GO:0017148; GO:0030598; GO:0090729; GO:0098676
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted.
|
SIGNAL 1..22; /evidence="ECO:0000255"
| null |
PF00161;
|
IPR036041;IPR001574;IPR017988;IPR016138;IPR016139;IPR016331;
|
1R4P;2GA4;7UJJ;8SZ2;
|
Viruses (no rank), Duplodnaviria (realm), Heunggongvirae (kingdom), Uroviricota (phylum), Caudoviricetes (class), Sepvirinae (subfamily), Traversvirus (genus), Traversvirus tv933W (species)
|
stxA2 stx2A L0103
| true |
Traversvirus tv933W
| 0 |
row_216
| false | null |
1,365 |
P09386
|
MKKMFMAVLFALASVNAMAADCAKGKIEFSKYNEDDTFTVKVDGKEYWTSRWNLQPLLQSAQLTGMTVTIKSSTCESGSGFAEVQFNND
|
Shiga-like toxin 2 subunit B (SLT-2 B subunit) (SLT-2b) (SLT-IIb) (Verocytotoxin 2 subunit B) (Verotoxin 2 subunit B)
|
Escherichia phage 933W (Bacteriophage 933W)
| 10,730 | 89 | 9,874 |
3D-structure;Disulfide bond;Modulation of host virulence by virus;Reference proteome;Secreted;Signal;Toxin;Viral exotoxin;Virulence
|
GO:0005576; GO:0019836; GO:0090729; GO:0098676
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted.
|
SIGNAL 1..19; /evidence="ECO:0000255"
| null |
PF02258;
|
IPR008992;IPR003189;
|
1R4P;2GA4;6FE4;7UJJ;
|
Viruses (no rank), Duplodnaviria (realm), Heunggongvirae (kingdom), Uroviricota (phylum), Caudoviricetes (class), Sepvirinae (subfamily), Traversvirus (genus), Traversvirus tv933W (species)
|
stxB2 stx2B L0104
| true |
Traversvirus tv933W
| 1 |
row_1306
| false | null |
715 |
Q805F6
|
MIQVLLVTLCLAAFPYQGSSIILESGNVNDYEVLYPQKVIALPKGAVQPKYEDTMQYEFKVNGEPVVLHLEKNKGLFSKDYSETHYSSDGRKITTNPPVEDHCYYHGRIQNDADSTASISACNGLKGHFKLQGETYLIEPLKLPDSEAHAVYKYENVEKEDEAPKMCGVTQTNWKSDKPIKKASQLNLTPEQQGFPQRYIELVVVADHRMFTKYNSNLNTIRIWVHELVNTMNVFYRPLNIRVSLTDLEVWSNRDLINVQPAAADTLEAFGDWRETVLLNRISHDNAQLLTAIELDGETIGLANRGTMCDPKLSTGIVQDHSAINLWVAVTMAHEMGHNLGISHDGNQCHCDANSCIMSEELREQLSFEFSDCSQNQYQTYLTDHNPQCMLNEPLRTDIVSTPVSGNELLETGEESDFDAPANPCCDAATCKLTTGSQCADGLCCDQCKFMKEGTVCRRARGDDLDDYCNGISAGCPRNPFHA
|
Zinc metalloproteinase/disintegrin [Cleaved into: Snake venom metalloproteinase (SVMP) (EC 3.4.24.-); Disintegrin acostatin-beta]
|
Agkistrodon contortrix contortrix (Southern copperhead)
| 8,713 | 483 | 54,026 |
3D-structure;Calcium;Cell adhesion impairing toxin;Direct protein sequencing;Disulfide bond;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Platelet aggregation inhibiting toxin;Protease;Secreted;Signal;Toxin;Zinc;Zymogen
|
GO:0004222; GO:0005576; GO:0005886; GO:0006508; GO:0046872; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted.
|
SIGNAL 1..20; /evidence="ECO:0000255"
| null |
PF00200;PF01562;PF01421;
|
IPR018358;IPR001762;IPR036436;IPR024079;IPR001590;IPR002870;IPR034027;
|
3C05;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Crotalinae (subfamily), Agkistrodon (genus), Agkistrodon contortrix (species)
| null | true |
Agkistrodon contortrix
| 0 |
row_669
| false | null |
518 |
P82981
|
VVGGDECNINEHRFLVAIFNSNGFVCSGTLINQEWVLTAAHCDSTDFQIKLGAHSKKVLNEDEQIRNPKEKFICPNKKNDEVLDKDIMLIKLDSRVSNSEHIAPLSLPSSPPSVGSVCHIMGWGSITPIEVTFPDVPHCAYINLLDDAACQPGYPEVLPEYRTLCAGILEGGKDTCNYDSGGPLICNGQFQGIVSYGAHPCGQSLKPGIYTKVFDYNDWIQSIIAGNTAATCPP
|
Thrombin-like enzyme contortrixobin (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Venombin B)
|
Agkistrodon contortrix contortrix (Southern copperhead)
| 8,713 | 234 | 25,413 |
Blood coagulation cascade activating toxin;Direct protein sequencing;Disulfide bond;Hemostasis impairing toxin;Hydrolase;Protease;Secreted;Serine protease;Toxin
|
GO:0004252; GO:0005576; GO:0006508; GO:0030141; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted.
| null | null |
PF00089;
|
IPR009003;IPR043504;IPR001314;IPR001254;IPR018114;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Crotalinae (subfamily), Agkistrodon (genus), Agkistrodon contortrix (species)
| null | true |
Agkistrodon contortrix
| 1 |
row_482
| false | null |
234 |
P09872
|
VIGGDECNINEHRFLALVYANGSLCGGTLINQEWVLTARHCDRGNMRIYLGMHNLKVLNKDALRRFPKEKYFCLNTRNDTIWDKDIMLIRLNRPVRNSAHIAPLSLPSNPPSVGSVCRIMGWGTITSPNATLPDVPHCANINILDYAVCQAAYKGLAATTLCAGILEGGKDTCKGDSGGPLICNGQFQGILSVGGNPCAQPRKPGIYTKVFDYTDWIQSIISGNTDATCPP
|
Protein C activator (EC 3.4.21.-) (ACC-C) (Snake venom serine protease) (SVSP)
|
Agkistrodon contortrix contortrix (Southern copperhead)
| 8,713 | 231 | 25,106 |
3D-structure;Blood coagulation cascade inhibiting toxin;Direct protein sequencing;Disulfide bond;Glycoprotein;Hemostasis impairing toxin;Hydrolase;Protease;Secreted;Serine protease;Toxin
|
GO:0004252; GO:0005576; GO:0006508; GO:0030141; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted.
| null | null |
PF00089;
|
IPR009003;IPR043504;IPR001314;IPR001254;IPR033116;
|
2AIP;2AIQ;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Crotalinae (subfamily), Agkistrodon (genus), Agkistrodon contortrix (species)
| null | true |
Agkistrodon contortrix
| 2 |
row_219
| false | null |
407 |
P28891
|
QQRFPQRYVQLVIVADHRMNTKYNGDSDKIRQWVHQIVNTINEIYRPLNIQFTLVGLEIWSNQDLITVTSVSHDTLASFGNWRETDLLRRQRHDNAQLLTAIDFDGDTVGLAYVGGMCQLKHSTGVIQDHSAINLLVALTMAHELGHNLGMNHDGNQCHCGANSCVMAAMLSDQPSKLFSDCSKKDYQTFLTVNNPQCILNKP
|
Snake venom metalloproteinase fibrolase (SVMP) (EC 3.4.24.72) (Fibrinolytic metalloproteinase) (Fibrinolytic proteinase) (Alfimeprase)
|
Agkistrodon contortrix contortrix (Southern copperhead)
| 8,713 | 203 | 22,908 |
Direct protein sequencing;Disulfide bond;Fibrinolytic toxin;Hemostasis impairing toxin;Hydrolase;Metal-binding;Metalloprotease;Pharmaceutical;Protease;Pyrrolidone carboxylic acid;Secreted;Toxin;Zinc
|
GO:0004222; GO:0005576; GO:0005886; GO:0006508; GO:0046872; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1304358, ECO:0000269|PubMed:1898066}.
| null | null |
PF01421;
|
IPR024079;IPR001590;IPR034027;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Crotalinae (subfamily), Agkistrodon (genus), Agkistrodon contortrix (species)
| null | true |
Agkistrodon contortrix
| 3 |
row_373
| false | null |
968 |
B8QCG6
|
FLIGIWAAPKSEDNVPLGSPATSDLSDTSCAKTHEALKTSRNIDQHYPAPKKAEDQEFGSAANIIVDPKLFQKRRFQSPRVLFSTQPPPLSRDEQNVDNANSLNRNIRAKREDHPVHNRGEYSVCDSVNVWVANKTTATDIRGNVVTVMVDVNINNNVYKQYFFETKCRNPNPVPTGCRGIDARHWNSYC
|
Venom nerve growth factor (v-NGF) (vNGF)
|
Agkistrodon contortrix contortrix (Southern copperhead)
| 8,713 | 190 | 21,385 |
Cleavage on pair of basic residues;Disulfide bond;Glycoprotein;Growth factor;Lipid-binding;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Secreted;Signal;Toxin
|
GO:0005163; GO:0005615; GO:0007169; GO:0008021; GO:0008083; GO:0008289; GO:0021675; GO:0030414; GO:0030424; GO:0030425; GO:0038180; GO:0043524; GO:0048812; GO:0050804; GO:0090729
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21801740}.
|
SIGNAL <1..7; /evidence="ECO:0000255"
| null |
PF00243;
|
IPR029034;IPR020408;IPR002072;IPR020425;IPR019846;IPR020433;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Crotalinae (subfamily), Agkistrodon (genus), Agkistrodon contortrix (species)
| null | true |
Agkistrodon contortrix
| 4 |
row_913
| false | null |
716 |
Q805F7
|
MIQVLLVTLCLAVFPYQGSSIILESGNVNDYEVVYPRKVTALPKGAIQPKNPCCDAATCKLTPGSQCAEGLCCDQCKFIKAGKICRRARGDNPDYRCTGQSGDCPRKHFYA
|
Disintegrin acostatin-alpha [Cleaved into: Disintegrin acostatin-alpha, processed form]
|
Agkistrodon contortrix contortrix (Southern copperhead)
| 8,713 | 111 | 12,093 |
3D-structure;Cell adhesion impairing toxin;Direct protein sequencing;Disulfide bond;Hemostasis impairing toxin;Platelet aggregation inhibiting toxin;Pyrrolidone carboxylic acid;Secreted;Signal;Toxin
|
GO:0005576; GO:0005886; GO:0007155; GO:0030195; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted.
|
SIGNAL 1..20; /evidence="ECO:0000255"
| null |
PF00200;
|
IPR018358;IPR001762;IPR036436;
|
3C05;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Crotalinae (subfamily), Agkistrodon (genus), Agkistrodon contortrix (species)
| null | true |
Agkistrodon contortrix
| 5 |
row_670
| false | null |
1,470 |
P0DF97
|
MSNKKTFKKYSRVAGLLTAALIIGNLVTANAESNKQNTASTETTTTNEQPKPESSELTTEKAGQKTDDMLNSNDMIKLAPKEMPLESAEKEEKKSEDKKKSEEDHTEEINDKIYSLNYNELEVLAKNGETIENFVPKEGVKKADKFIVIERKKKNINTTPVDISIIDSVTDRTYPAALQLANKGFTENKPDAVVTKRNPQKIHIDLPGMGDKATVEVNDPTYANVSTAIDNLVNQWHDNYSGGNTLPARTQYTESMVYSKSQIEAALNVNSKILDGTLGIDFKSISKGEKKVMIAAYKQIFYTVSANLPNNPADVFDKSVTFKELQRKGVSNEAPPLFVSNVAYGRTVFVKLETSSKSNDVEAAFSAALKGTDVKTNGKYSDILENSSFTAVVLGGDAAEHNKVVTKDFDVIRNVIKDNATFSRKNPAYPISYTSVFLKNNKIAGVNNRTEYVETTSTEYTSGKINLSHQGAYVAQYEILWDEINYDDKGKEVITKRRWDNNWYSKTSPFSTVIPLGANSRNIRIMARECTGLAWEWWRKVIDERDVKLSKEINVNISGSTLSPYGSITYK
|
Streptolysin O (SLO) (Thiol-activated cytolysin)
|
Streptococcus pyogenes serotype M3 (strain SSI-1)
| 193,567 | 571 | 63,638 |
3D-structure;Cytolysis;Hemolysis;Host cell membrane;Host membrane;Lipid-binding;Membrane;Secreted;Signal;Toxin;Transmembrane;Transmembrane beta strand;Virulence
|
GO:0005576; GO:0015485; GO:0016020; GO:0020002; GO:0031640; GO:0090729
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C2J9}. Host cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q04IN8}. Note=Probably secreted as soluble protein by the accessory Sec system (By similarity). It then inserts into the host cell membrane and forms pores formed by transmembrane beta-strands (By similarity). {ECO:0000250|UniProtKB:P0C2J9, ECO:0000250|UniProtKB:Q04IN8}.
|
SIGNAL 1..33; /evidence="ECO:0000255"
|
TRANSMEM 260..273; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:Q04IN8"; TRANSMEM 280..289; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:Q04IN8"; TRANSMEM 358..367; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:Q04IN8"; TRANSMEM 375..387; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:Q04IN8"
|
PF17440;PF01289;
|
IPR035390;IPR038700;IPR001869;IPR036363;IPR036359;
|
4HSC;
|
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Bacillota (phylum), Bacilli (class), Lactobacillales (order), Streptococcaceae (family), Streptococcus (genus), Streptococcus pyogenes (species), Streptococcus pyogenes serotype M3 (serotype)
|
slo SPs0132
| true |
Streptococcus pyogenes
| 0 |
row_1409
| false | null |
242 |
P0C0J1
|
MNKKKLGVRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAEDIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP
|
Streptopain (EC 3.4.22.10) (Exotoxin type B) (Group A streptococcal cysteine protease) (Streptococcal cysteine proteinase) (SPE B) (Streptococcus peptidase A) (SPP)
|
Streptococcus pyogenes serotype M1
| 301,447 | 398 | 43,130 |
3D-structure;Autocatalytic cleavage;Direct protein sequencing;Host cytoplasm;Hydrolase;Methylation;Protease;Reference proteome;Secreted;Signal;Thiol protease;Toxin;Virulence;Zymogen
|
GO:0004197; GO:0005576; GO:0005829; GO:0006508; GO:0034050; GO:0042783; GO:0043655; GO:0044164; GO:0051604; GO:0090729; GO:0140321
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7516997}. Host extracellular space {ECO:0000269|PubMed:18160402, ECO:0000269|PubMed:7516997}. Host cytoplasm {ECO:0000269|PubMed:35545676}.
|
SIGNAL 1..27; /evidence="ECO:0000250|UniProtKB:P0C0J0"
| null |
PF13734;PF01640;
|
IPR038765;IPR000200;IPR025896;IPR044934;
|
2JTC;
|
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Bacillota (phylum), Bacilli (class), Lactobacillales (order), Streptococcaceae (family), Streptococcus (genus), Streptococcus pyogenes (species)
|
speB SPy_2039 M5005_Spy1735
| true |
Streptococcus pyogenes
| 1 |
row_226
| false | null |
293 |
P0DD38
|
MNKKKLGIRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAEDIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGEQSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQYNWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQSVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWGGVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP
|
Streptopain (EC 3.4.22.10) (Exotoxin type B) (SPE B) (Streptococcal cysteine proteinase) (Streptococcus peptidase A) (SPP)
|
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
| 198,466 | 398 | 43,174 |
Autocatalytic cleavage;Host cytoplasm;Hydrolase;Methylation;Protease;Secreted;Signal;Thiol protease;Toxin;Virulence;Zymogen
|
GO:0004197; GO:0005576; GO:0006508; GO:0034050; GO:0042783; GO:0043655; GO:0044164; GO:0090729; GO:0140321
|
Inferred from homology
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7516997}. Host extracellular space {ECO:0000269|PubMed:7516997}. Host cytoplasm {ECO:0000250|UniProtKB:P0C0J0}.
|
SIGNAL 1..27; /evidence="ECO:0000250|UniProtKB:P0C0J0"
| null |
PF13734;PF01640;
|
IPR038765;IPR000200;IPR025896;IPR044934;
| null |
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Bacillota (phylum), Bacilli (class), Lactobacillales (order), Streptococcaceae (family), Streptococcus (genus), Streptococcus pyogenes (species), Streptococcus pyogenes serotype M3 (serotype)
|
speB SpyM3_1742
| true |
Streptococcus pyogenes
| 2 |
row_277
| false | null |
6,821 |
P62561
|
MENNKKVLKKMVFFVLVTFLGLTISQEVFAQQDPDPSQLHRSSLVKNLQNIYFLYEGDPVTHENVKSVDQLLSHDLIYNVSGPNYDKLKTELKNQEMATLFKDKNVDIYGVEYYHLCYLCENAERSACIYGGVTNHEGNHLEIPKKIVVKVSIDGIQSLSFDIETNKKMVTAQELDYKVRKYLTDNKQLYTNGPSKYETGYIKFIPKNKESFWFDFFPEPEFTQSKYLMIYKDNETLDSNTSQIEVYLTTK
|
Exotoxin type A (Erythrogenic toxin) (SPE A) (Scarlet fever toxin)
|
Streptococcus pyogenes serotype M18 (strain MGAS8232)
| 186,103 | 251 | 29,246 |
3D-structure;Disulfide bond;Signal;Toxin;Virulence
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 2 | null |
SIGNAL 1..30; /evidence="ECO:0000250"
| null |
PF02876;PF01123;
|
IPR008992;IPR006126;IPR006173;IPR016091;IPR013307;IPR006123;IPR006177;
|
1L0Y;
|
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Bacillota (phylum), Bacilli (class), Lactobacillales (order), Streptococcaceae (family), Streptococcus (genus), Streptococcus pyogenes (species), Streptococcus pyogenes serotype M18 (serotype)
|
speA spyM18_0393
| true |
Streptococcus pyogenes
| 3 |
row_6568
| false | null |
6,085 |
P0C0I7
|
MRYNCRYSHIDKKIYSMIICLSFLLYSNVVQANSYNTTNRHNLESLYKHDSNLIEADSIKNSPDIVTSHMLKYSVKDKNLSVFFEKDWISQEFKDKEVDIYALSAQEVCECPGKRYEAFGGITLTNSEKKEIKVPVNVWDKSKQQPPMFITVNKPKVTAQEVDIKVRKLLIKKYDIYNNREQKYSKGTVTLDLNSGKDIVFDLYYFGNGDFNSMLKIYSNNERIDSTQFHVDVSIS
|
Exotoxin type H (SPE H)
|
Streptococcus pyogenes serotype M1
| 301,447 | 236 | 27,485 |
Reference proteome;Secreted;Signal;Toxin;Virulence
|
GO:0005576; GO:0090729
|
Inferred from homology
| 2 |
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
|
SIGNAL 1..32; /evidence="ECO:0000255"
| null |
PF02876;PF01123;
|
IPR008992;IPR006126;IPR006173;IPR016091;IPR013307;IPR006123;
| null |
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Bacillota (phylum), Bacilli (class), Lactobacillales (order), Streptococcaceae (family), Streptococcus (genus), Streptococcus pyogenes (species)
|
speH SPy_1008
| true |
Streptococcus pyogenes
| 4 |
row_5843
| false | null |
4,763 |
Q8NKX2
|
MKKINIIKIVFIITVILISTISPIIKSDSKKDISNVKSDLLYAYTITPYDYKDCRVNFSTTHTLNIDTQKYRGKDYYISSEMSYEASQKFKRDDHVDVFGLFYILNSHTGEYIYGGITPAQNNKVNHKLLGNLFISGESQQNLNNKIILEKDIVTFQEIDFKIRKYLMDNYKIYDATSPYVSGRIEIGTKDGKHEQIDLFDSPNEGTRSDIFAKYKDNRIINMKNFSHFDIYLEK
|
Exotoxin type C (SPE C)
|
Streptococcus pyogenes serotype M18 (strain MGAS8232)
| 186,103 | 235 | 27,372 |
3D-structure;Direct protein sequencing;Signal;Toxin;Virulence;Zinc
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 3 | null |
SIGNAL 1..27; /evidence="ECO:0000269|PubMed:3045005"
| null |
PF02876;PF01123;
|
IPR008992;IPR006126;IPR006173;IPR016091;IPR013307;IPR006123;IPR006177;
|
1AN8;1HQR;1KTK;
|
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Bacillota (phylum), Bacilli (class), Lactobacillales (order), Streptococcaceae (family), Streptococcus (genus), Streptococcus pyogenes (species), Streptococcus pyogenes serotype M18 (serotype)
|
speC spyM18_0778
| true |
Streptococcus pyogenes
| 5 |
row_4539
| false | null |
6,312 |
P0DG08
|
MKTNILTIIILSCVFSYGSQLAYADENLKDLKRSLRFAYNITPCDYENVEIAFVTTNSIHINTKQKRSECILYVDSIVSLGITDQFIKGDKVDVFGLPYNFSPPYVDNIYGGIVKHSNQGNKSLQFVGILNQDGKETYLPSEVVRIKKKQFTLQEFDLKIRKFLMEKYNIYDSESRYTSGSLFLATKDSKHYEVDLFNKDDKLLSRDSFFKRYKDNKIFNSEEISHFDIYLKTY
|
Exotoxin type G (Pyrogenic exotoxin G) (SPE G)
|
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
| 198,466 | 234 | 27,282 |
Signal;Toxin;Virulence
|
GO:0005576; GO:0090729
|
Inferred from homology
| 2 | null |
SIGNAL 1..24; /evidence="ECO:0000255"
| null |
PF02876;PF01123;
|
IPR008992;IPR006126;IPR006173;IPR016091;IPR013307;IPR006123;IPR006177;
| null |
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Bacillota (phylum), Bacilli (class), Lactobacillales (order), Streptococcaceae (family), Streptococcus (genus), Streptococcus pyogenes (species), Streptococcus pyogenes serotype M3 (serotype)
|
speG SpyM3_0155
| true |
Streptococcus pyogenes
| 6 |
row_6064
| false | null |
256 |
P0C2E9
|
MIRFKKTKLIASIAMALCLFSQPVISFSKDITDKNQSIDSGISSLSYNRNEVLASNGDKIESFVPKEGKKTGNKFIVVERQKRSLTTSPVDISIIDSVNDRTYPGALQLADKAFVENRPTILMVKRKPININIDLPGLKGENSIKVDDPTYGKVSGAIDELVSKWNEKYSSTHTLPARTQYSESMVYSKSQISSALNVNAKVLENSLGVDFNAVANNEKKVMILAYKQIFYTVSADLPKNPSDLFDDSVTFNDLKQKGVSNEAPPLMVSNVAYGRTIYVKLETTSSSKDVQAAFKALIKNTDIKNSQQYKDIYENSSFTAVVLGGDAQEHNKVVTKDFDEIRKVIKDNATFSTKNPAYPISYTSVFLKDNSVAAVHNKTDYIETTSTEYSKGKINLDHSGAYVAQFEVAWDEVSYDKEGNEVLTHKTWDGNYQDKTAHYSTVIPLEANARNIRIKARECTGLAWEWWRDVISEYDVPLTNNINVSIWGTTLYPGSSITYN
|
Perfringolysin O (PFO) (Theta-toxin) (Thiol-activated cytolysin)
|
Clostridium perfringens (strain 13 / Type A)
| 195,102 | 500 | 55,830 |
3D-structure;Cytolysis;Direct protein sequencing;Hemolysis;Host cell membrane;Host membrane;Lipid-binding;Membrane;Reference proteome;Secreted;Signal;Toxin;Transmembrane;Transmembrane beta strand;Virulence
|
GO:0001897; GO:0005576; GO:0015485; GO:0016020; GO:0020002; GO:0044179; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2878682}. Host cell membrane; Multi-pass membrane protein {ECO:0000305|PubMed:15851031}. Note=Secreted as soluble protein that then inserts into the host cell membrane and forms huge pores formed by transmembrane beta-strands. {ECO:0000305|PubMed:15851031}.
|
SIGNAL 1..28; /evidence="ECO:0000269|PubMed:2878682"
|
TRANSMEM 189..202; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:Q04IN8"; TRANSMEM 209..218; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:Q04IN8"; TRANSMEM 287..296; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:Q04IN8"; TRANSMEM 304..316; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:Q04IN8"
|
PF17440;PF01289;
|
IPR035390;IPR038700;IPR001869;IPR036363;IPR036359;
|
1M3I;1M3J;1PFO;2BK1;2BK2;5DHL;5DIM;
|
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Bacillota (phylum), Clostridia (class), Eubacteriales (order), Clostridiaceae (family), Clostridium (genus), Clostridium perfringens (species)
|
pfo pfoA pfoR CPE0163
| true |
Clostridium perfringens
| 0 |
row_240
| false | null |
250 |
P0C216
|
MKRKICKALICATLATSLWAGASTKVYAWDGKIDGTGTHAMIVTQGVSILENDLSKNEPESVRKNLEILKENMHELQLGSTYPDYDKNAYDLYQDHFWDPDTDNNFSKDNSWYLAYSIPDTGESQIRKFSALARYEWQRGNYKQATFYLGEAMHYFGDIDTPYHPANVTAVDSAGHVKFETFAEERKEQYKINTAGCKTNEDFYADILKNKDFNAWSKEYARGFAKTGKSIYYSHASMSHSWDDWDYAAKVTLANSQKGTAGYIYRFLHDVSEGNDPSVGKNVKELVAYISTSGEKDAGTDDYMYFGIKTKDGKTQEWEMDNPGNDFMTGSKDTYTFKLKDENLKIDDIQNMWIRKRKYTAFPDAYKPENIKIIANGKVVVDKDINEWISGNSTYNIK
|
Phospholipase C (PLC) (EC 3.1.4.3) (Alpha-toxin) (Hemolysin) (Lecithinase) (Phosphatidylcholine cholinephosphohydrolase)
|
Clostridium perfringens (strain 13 / Type A)
| 195,102 | 398 | 45,530 |
3D-structure;Calcium;Cytolysis;Hemolysis;Hydrolase;Metal-binding;Reference proteome;Secreted;Signal;Toxin;Virulence;Zinc
|
GO:0005576; GO:0008270; GO:0031640; GO:0034480; GO:0050429; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
|
SIGNAL 1..28; /evidence="ECO:0000250"
| null |
PF01477;PF00882;
|
IPR001024;IPR036392;IPR008947;IPR029002;IPR001531;
|
1CA1;1GYG;1QM6;1QMD;
|
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Bacillota (phylum), Clostridia (class), Eubacteriales (order), Clostridiaceae (family), Clostridium (genus), Clostridium perfringens (species)
|
plc cpa CPE0036
| true |
Clostridium perfringens
| 1 |
row_234
| false | null |
253 |
P0C250
|
MGKLTILVLVAAVLLSTQVMVQGDGDQPADRNAVRRDDNPGGTRGRFMNILRRTGCPWDPWCG
|
Contryphan-Lo (Contryphan-Lo1) (Lo959) [Cleaved into: Contryphan-Lo Lo902]
|
Conus buxeus loroisii (Cone snail) (Conus loroisii)
| 410,709 | 63 | 6,897 |
3D-structure;Amidation;Calcium channel impairing toxin;D-amino acid;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Secreted;Signal;Toxin;Voltage-gated calcium channel impairing toxin
|
GO:0005246; GO:0005576; GO:0008200; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16387709, ECO:0000269|PubMed:16945451}.
|
SIGNAL 1..23; /evidence="ECO:0000255"
| null |
PF02950;
|
IPR004214;IPR011062;
|
2M6G;2M6H;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Spiralia (clade), Lophotrochozoa (clade), Mollusca (phylum), Gastropoda (class), Caenogastropoda (subclass), Neogastropoda (order), Conoidea (superfamily), Conidae (family), Conus (genus), Dendroconus (subgenus), Conus buxeus (species)
| null | true |
Conus buxeus
| 0 |
row_237
| false | null |
832 |
A0A1P8NVU0
|
MGKLTILVLVAAVLLSTQAMVQDQPADRNAVRRNDNPGGASRKSINVLHRNECPWQPWCG
|
Contryphan-Lo2 (Lo1158)
|
Conus buxeus loroisii (Cone snail) (Conus loroisii)
| 410,709 | 60 | 6,598 |
Amidation;D-amino acid;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Secreted;Signal;Toxin
|
GO:0005576; GO:0008200; GO:0090729
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28152596}.
|
SIGNAL 1..19; /evidence="ECO:0000255"
| null |
PF02950;
|
IPR004214;IPR011062;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Spiralia (clade), Lophotrochozoa (clade), Mollusca (phylum), Gastropoda (class), Caenogastropoda (subclass), Neogastropoda (order), Conoidea (superfamily), Conidae (family), Conus (genus), Dendroconus (subgenus), Conus buxeus (species)
| null | true |
Conus buxeus
| 1 |
row_781
| false | null |
1,700 |
P31854
|
MRTLWIVAVWLMGVEGNLFQFGNMINHMVGKHAVWSYLSYGCYCGWGGQGKPQDATDRCCFVHDCCYGRANGCDPKLSTYSYNFQNGNIVCGNKYGCLRHICECDRVAAICFQKNMNTYNKKYKNYSSSNCQENSDKC
|
Basic phospholipase A2 Pla2Vb (VbbPLA2) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
|
Vipera berus berus (Common viper)
| 31,156 | 138 | 15,716 |
Blood coagulation cascade inhibiting toxin;Calcium;Direct protein sequencing;Disulfide bond;Hemostasis impairing toxin;Hydrolase;Lipid degradation;Lipid metabolism;Metal-binding;Secreted;Signal;Toxin
|
GO:0005509; GO:0005543; GO:0005576; GO:0006644; GO:0016042; GO:0047498; GO:0050482; GO:0090729
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8499481}.
|
SIGNAL 1..16; /evidence="ECO:0000269|PubMed:8499481"
| null |
PF00068;
|
IPR001211;IPR033112;IPR016090;IPR036444;IPR033113;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Viperinae (subfamily), Vipera (genus), Vipera berus (species)
| null | true |
Vipera berus
| 0 |
row_1629
| false | null |
255 |
P0C2D7
|
ADDKNPLEECFREDDYEEFLEIAKNGLKKTSNPKHIVYPVKPSEQLYEESLRDQLPTSMHRYPSMIQKIFFAGEYTANAHGWIDSTIK
|
L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2)
|
Vipera berus berus (Common viper)
| 31,156 | 88 | 10,295 |
Antibiotic;Antimicrobial;Apoptosis;Cytolysis;Direct protein sequencing;Disulfide bond;FAD;Flavoprotein;Glycoprotein;Hemolysis;Hemostasis impairing toxin;Oxidoreductase;Platelet aggregation inhibiting toxin;Secreted;Toxin
|
GO:0005576; GO:0006915; GO:0031640; GO:0042742; GO:0050025; GO:0090729; GO:0106329
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16574513}.
| null | null | null | null | null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Viperinae (subfamily), Vipera (genus), Vipera berus (species)
| null | true |
Vipera berus
| 1 |
row_239
| false | null |
3,270 |
P0C6A6
|
NSGNPCCDPVTCKPRRGEHCVSGPCCRNCKFLNAGTICKYARGDDMNDYCTGISSDCPRNPYKD
|
Disintegrin VB7A
|
Vipera berus berus (Common viper)
| 31,156 | 64 | 7,009 |
Cell adhesion impairing toxin;Direct protein sequencing;Disulfide bond;Hemostasis impairing toxin;Platelet aggregation inhibiting toxin;Secreted;Toxin
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12667142}.
| null | null |
PF00200;
|
IPR018358;IPR001762;IPR036436;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Viperinae (subfamily), Vipera (genus), Vipera berus (species)
| null | true |
Vipera berus
| 2 |
row_3153
| false | null |
3,271 |
P0C6A7
|
ELLQNSGNPCCDPVTCKPREGEHCISGPCCRNCKFKRAGTVCLDAKGDWMNNYCTGISSDCPRN
|
Disintegrin VB7B
|
Vipera berus berus (Common viper)
| 31,156 | 64 | 6,998 |
Cell adhesion impairing toxin;Direct protein sequencing;Disulfide bond;Hemostasis impairing toxin;Platelet aggregation inhibiting toxin;Secreted;Toxin
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12667142}.
| null | null |
PF00200;
|
IPR001762;IPR036436;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Viperinae (subfamily), Vipera (genus), Vipera berus (species)
| null | true |
Vipera berus
| 3 |
row_3154
| false | null |
313 |
P0DJN7
|
MRTFWIVAVLLVGVEGNLLQFNKMIKIMTKKNAIPFYTSYGCYCGWGGRGRPKDATDRCCFVHDCCYEKLTDCSPKTARYSYSWKSGVIICGEGTPCEKQICECDRAAAVCFGANLSTYKKRYMFYPDLLCTDPSEKC
|
Basic phospholipase A2 Cll-N6 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
|
Crotalus lepidus lepidus (Mottled rock rattlesnake)
| 992,932 | 138 | 15,648 |
Calcium;Direct protein sequencing;Disulfide bond;Hydrolase;Lipid degradation;Lipid metabolism;Metal-binding;Myotoxin;Secreted;Signal;Toxin
|
GO:0004623; GO:0005576; GO:0016042; GO:0046872; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15032748}.
|
SIGNAL 1..16; /evidence="ECO:0000269|PubMed:15032748"
| null |
PF00068;
|
IPR001211;IPR033112;IPR016090;IPR036444;IPR033113;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Crotalinae (subfamily), Crotalus (genus), Crotalus lepidus (species)
| null | true |
Crotalus lepidus
| 0 |
row_295
| false | null |
1,189 |
C0LZJ5
|
IVSPPVCGNELLENGEECDCGSPANCRNPCCDAASCRLHSWVECESGECCDQCRFVTAGTECRATRSECDLAGQCTGQSADCPIDRFHRNGQPCLQNYGYCYNGKCPIMHHQCYYLFGANATVAQDACFEENKNGIGDFYCRKQSDRLIPCAPEDVKCGRLFCEILPNTRCKHAPGDNGMVDPGTKCEDKKVCFNRKCVDVNTVY
|
Disintegrin-like leberagin-C
|
Macrovipera lebetina transmediterranea (Blunt-nosed viper) (Vipera lebetina transmediterranea)
| 384,075 | 205 | 22,634 |
Cell adhesion impairing toxin;Direct protein sequencing;Disulfide bond;Glycoprotein;Hemostasis impairing toxin;Platelet aggregation inhibiting toxin;Secreted;Toxin
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted.
| null | null |
PF08516;PF00200;
|
IPR006586;IPR018358;IPR001762;IPR036436;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Viperinae (subfamily), Macrovipera (genus), Macrovipera lebetinus (species)
| null | true |
Macrovipera lebetinus
| 0 |
row_1134
| false | null |
964 |
B5U6Z2
|
MRTLWIVAVCLMGVEGHLTQFGDMINKKTGTFGLLSYVYYGCYCGLGGKGKPQDATDRCCFVHDCCYGTVNGCDPKLSTYSYSFQNGDIVCGDDDPCLRAVCECDRVAAICFGENMNTYDKKYMLYSLFDCMEESEKC
|
Acidic phospholipase A2 MVL-PLA2 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
|
Macrovipera lebetina transmediterranea (Blunt-nosed viper) (Vipera lebetina transmediterranea)
| 384,075 | 138 | 15,399 |
Cell adhesion impairing toxin;Direct protein sequencing;Disulfide bond;Hydrolase;Lipid degradation;Lipid metabolism;Metal-binding;Secreted;Signal;Toxin
|
GO:0005509; GO:0005543; GO:0005576; GO:0006644; GO:0016042; GO:0047498; GO:0050482; GO:0090729
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
|
SIGNAL 1..16; /evidence="ECO:0000269|PubMed:19351557"
| null |
PF00068;
|
IPR001211;IPR033112;IPR016090;IPR036444;IPR033113;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Viperinae (subfamily), Macrovipera (genus), Macrovipera lebetinus (species)
| null | true |
Macrovipera lebetinus
| 1 |
row_909
| false | null |
3,274 |
P0C6B0
|
MNSANPCCDPITCKPRRGEHCVSGPCCRNCKFLNPGTICKRTMLDGLNDYCTGVTSDCPRNPWKSEEED
|
Disintegrin VLO5B
|
Macrovipera lebetina obtusa (Levant blunt-nosed viper) (Vipera lebetina obtusa)
| 209,528 | 69 | 7,670 |
Cell adhesion impairing toxin;Direct protein sequencing;Disulfide bond;Hemostasis impairing toxin;Platelet aggregation inhibiting toxin;Secreted;Toxin
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12667142}.
| null | null |
PF00200;
|
IPR018358;IPR001762;IPR036436;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Viperinae (subfamily), Macrovipera (genus), Macrovipera lebetinus (species)
| null | true |
Macrovipera lebetinus
| 2 |
row_3157
| false | null |
3,272 |
P0C6A8
|
MNSGNPCCDPVTCKPRRGEHCVSGPCCRNCKFLNAGTICKRARGDDMNDYCTGISPDCPRNPWKG
|
Disintegrin VLO4
|
Macrovipera lebetina obtusa (Levant blunt-nosed viper) (Vipera lebetina obtusa)
| 209,528 | 65 | 7,108 |
Cell adhesion impairing toxin;Direct protein sequencing;Disulfide bond;Hemostasis impairing toxin;Platelet aggregation inhibiting toxin;Secreted;Toxin
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12667142}.
| null | null |
PF00200;
|
IPR018358;IPR001762;IPR036436;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Viperinae (subfamily), Macrovipera (genus), Macrovipera lebetinus (species)
| null | true |
Macrovipera lebetinus
| 3 |
row_3155
| false | null |
3,273 |
P0C6A9
|
NSGNPCCDPVTCQPRRGEHCVSGKCCRNCKFLRAGTVCKRAVGDDMDDYCTGISSDCPRNPYKD
|
Disintegrin VLO5A
|
Macrovipera lebetina obtusa (Levant blunt-nosed viper) (Vipera lebetina obtusa)
| 209,528 | 64 | 7,005 |
Cell adhesion impairing toxin;Direct protein sequencing;Disulfide bond;Hemostasis impairing toxin;Platelet aggregation inhibiting toxin;Secreted;Toxin
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12667142}.
| null | null |
PF00200;
|
IPR018358;IPR001762;IPR036436;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Viperinae (subfamily), Macrovipera (genus), Macrovipera lebetinus (species)
| null | true |
Macrovipera lebetinus
| 4 |
row_3156
| false | null |
1,869 |
P83469
|
CTTGPCCRQCKLKPAGTTCWKTSLTSHYCTGKSCDCPLYPG
|
Disintegrin obtustatin
|
Macrovipera lebetina obtusa (Levant blunt-nosed viper) (Vipera lebetina obtusa)
| 209,528 | 41 | 4,401 |
3D-structure;Angiogenesis;Cell adhesion impairing toxin;Developmental protein;Differentiation;Direct protein sequencing;Disulfide bond;Secreted;Toxin
|
GO:0001525; GO:0005576; GO:0030154; GO:0090729
|
Evidence at protein level
| 4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12538900}.
| null | null | null |
IPR001762;IPR036436;
|
1MPZ;
|
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Viperinae (subfamily), Macrovipera (genus), Macrovipera lebetinus (species)
| null | true |
Macrovipera lebetinus
| 5 |
row_1794
| false | null |
342 |
P0DRC8
|
QFSDCSKDEYQRYLT
|
Snake venom metalloproteinase Mlp4.2 (SVMP) (EC 3.4.24.-)
|
Macrovipera lebetina transmediterranea (Blunt-nosed viper) (Vipera lebetina transmediterranea)
| 384,075 | 15 | 1,883 |
Calcium;Direct protein sequencing;Disulfide bond;Glycoprotein;Hydrolase;Magnesium;Metal-binding;Metalloprotease;Myotoxin;Protease;Secreted;Toxin;Zinc
|
GO:0004222; GO:0005576; GO:0006508; GO:0044523; GO:0046872; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20398688}.
| null | null | null | null | null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Viperinae (subfamily), Macrovipera (genus), Macrovipera lebetinus (species)
| null | true |
Macrovipera lebetinus
| 6 |
row_319
| false | null |
3,937 |
P25674
|
IRCFITPDVTSQACPDGHVCYTKMWCDNFCGMRGKRVDLGCAATCPTVKPGVDIKCCSTDNCNPFPTRKRS
|
Long neurotoxin 1 (Toxin CM-5)
|
Naja haje haje (Egyptian cobra)
| 8,642 | 71 | 7,821 |
Acetylcholine receptor inhibiting toxin;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Postsynaptic neurotoxin;Secreted;Toxin
|
GO:0005576; GO:0030550; GO:0090729; GO:0099106
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:718974}.
| null | null |
PF21947;
|
IPR003571;IPR045860;IPR018354;IPR054131;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Naja (genus), Naja haje (species)
| null | true |
Naja haje
| 0 |
row_3782
| false | null |
6,039 |
P01401
|
LTCLICPEKYCNKVHTCRNGENQCFKRFNERKLLGKRYTRGCAATCPEAKPREIVECCTTDRCNK
|
Weak toxin CM-11
|
Naja haje haje (Egyptian cobra)
| 8,642 | 65 | 7,546 |
Direct protein sequencing;Disulfide bond;Secreted;Toxin
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 2 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:710433}.
| null | null |
PF21947;
|
IPR003571;IPR045860;IPR018354;IPR054131;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Naja (genus), Naja haje (species)
| null | true |
Naja haje
| 1 |
row_5798
| false | null |
4,146 |
P62394
|
LKCHNTQLPFIYKTCPEGKNLCFKTTLKKLPLKIPIKRGCAATCPKSSALLKVVCCSTDKCN
|
Cytotoxin 11 (Toxin CM-12)
|
Naja haje haje (Egyptian cobra)
| 8,642 | 62 | 6,842 |
Direct protein sequencing;Disulfide bond;Membrane;Secreted;Target cell membrane;Target membrane;Toxin
|
GO:0005576; GO:0016020; GO:0044218; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:710433}. Target cell membrane {ECO:0000250|UniProtKB:P62375}.
| null | null |
PF21947;
|
IPR003572;IPR003571;IPR045860;IPR018354;IPR054131;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Naja (genus), Naja haje (species)
| null | true |
Naja haje
| 2 |
row_3981
| false | null |
3,938 |
P25675
|
MICHNQQSSQPPTIKTCPGETNCYKKQWRDHRGTIIERGCGCPSVKKGVGIYCCKTDKCNR
|
Short neurotoxin 2 (Toxin CM-10a)
|
Naja haje haje (Egyptian cobra)
| 8,642 | 61 | 6,888 |
Acetylcholine receptor inhibiting toxin;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Postsynaptic neurotoxin;Secreted;Toxin
|
GO:0005576; GO:0030550; GO:0090729; GO:0099106
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:718974}.
| null | null |
PF21947;
|
IPR003571;IPR045860;IPR018354;IPR054131;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Naja (genus), Naja haje (species)
| null | true |
Naja haje
| 3 |
row_3783
| false | null |
4,161 |
P68418
|
LECHNQQSSQPPTTKTCPGETNCYKKRWRDHRGSITERGCGCPSVKKGIEINCCTTDKCNN
|
Short neurotoxin 1 (Toxin CM-6)
|
Naja haje haje (Egyptian cobra)
| 8,642 | 61 | 6,844 |
Acetylcholine receptor inhibiting toxin;Direct protein sequencing;Disulfide bond;Ion channel impairing toxin;Neurotoxin;Postsynaptic neurotoxin;Secreted;Toxin
|
GO:0005576; GO:0030550; GO:0090729; GO:0099106
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:718974}.
| null | null |
PF21947;
|
IPR003571;IPR045860;IPR018354;IPR054131;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Naja (genus), Naja haje (species)
| null | true |
Naja haje
| 4 |
row_3996
| false | null |
6,048 |
P01415
|
FTCFTTPSDTSETCPDGQNICYEKRWNSHQGVEIKGCVASCPEFESRFRYLLCCRIDNCNK
|
Weak toxin CM-2
|
Naja haje haje (Egyptian cobra)
| 8,642 | 61 | 7,033 |
Direct protein sequencing;Disulfide bond;Secreted;Toxin
|
GO:0005576; GO:0090729
|
Evidence at protein level
| 2 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:710433}.
| null | null |
PF21947;
|
IPR003571;IPR045860;IPR018354;IPR054131;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Naja (genus), Naja haje (species)
| null | true |
Naja haje
| 5 |
row_5807
| false | null |
3,076 |
P01457
|
LKCHQLVPPFWKTCPEGKNLCYKMYMVSSSTVPVKRGCIDVCPKNSALVKYVCCNTDKCN
|
Cytotoxin 5 (Toxin CM-8)
|
Naja haje haje (Egyptian cobra)
| 8,642 | 60 | 6,773 |
Cardiotoxin;Cytolysis;Direct protein sequencing;Disulfide bond;Membrane;Secreted;Target cell membrane;Target membrane;Toxin
|
GO:0005576; GO:0016020; GO:0031640; GO:0044218; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:667107}. Target cell membrane {ECO:0000250|UniProtKB:P60301}.
| null | null |
PF21947;
|
IPR003572;IPR003571;IPR045860;IPR018354;IPR054131;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Naja (genus), Naja haje (species)
| null | true |
Naja haje
| 6 |
row_2974
| false | null |
346 |
P0DUG4
|
NVYQYRKMLQCAMPNGGPFECCQTHDNCYGEAEKLKACTSTHSSPYFK
|
Phospholipase A2 TI-Nh (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Thrombin inhibitor from Naja haje)
|
Naja haje haje (Egyptian cobra)
| 8,642 | 48 | 5,481 |
Blood coagulation cascade inhibiting toxin;Calcium;Direct protein sequencing;Disulfide bond;Hemostasis impairing toxin;Hydrolase;Metal-binding;Platelet aggregation inhibiting toxin;Secreted;Toxin
|
GO:0004623; GO:0005576; GO:0006644; GO:0046872; GO:0050482; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19622365}.
| null | null | null |
IPR036444;IPR033113;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Naja (genus), Naja haje (species)
| null | true |
Naja haje
| 7 |
row_321
| false | null |
4,336 |
P84807
|
DVDFNSESTRRKNKQKEIVDLHNSLKKTV
|
Cysteine-rich venom protein 25-A (CRVP-25h-A)
|
Naja haje haje (Egyptian cobra)
| 8,642 | 29 | 3,430 |
Direct protein sequencing;Disulfide bond;Secreted;Toxin
|
GO:0005576; GO:0006952; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15670767}.
| null | null | null | null | null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Naja (genus), Naja haje (species)
| null | true |
Naja haje
| 8 |
row_4168
| false | null |
4,335 |
P84804
|
DSSNLPPNQKQIVD
|
Cysteine-rich venom protein 23 (CRVP-23h)
|
Naja haje haje (Egyptian cobra)
| 8,642 | 14 | 1,555 |
Direct protein sequencing;Disulfide bond;Secreted;Toxin
|
GO:0005576; GO:0006952; GO:0090729
|
Evidence at protein level
| 3 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15670767}.
| null | null | null | null | null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Elapidae (family), Elapinae (subfamily), Naja (genus), Naja haje (species)
| null | true |
Naja haje
| 9 |
row_4167
| false | null |
352 |
P0DUN5
|
HLLQFNKNAIPFYAFYGCYCGWGGRCCFVHDCCYGKWDIYPYSLKSGYITCGKGTWCEEQICECDRVAAECLRRSLSTYKYGYMFYPDSRCRGPSETC
|
Basic phospholipase A2 Bbil-TX (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
|
Bothrops bilineatus smaragdinus (Two-striped forest-pitviper)
| 2,815,652 | 98 | 11,409 |
Calcium;Direct protein sequencing;Disulfide bond;Hydrolase;Lipid degradation;Lipid metabolism;Metal-binding;Myotoxin;Neurotoxin;Presynaptic neurotoxin;Secreted;Toxin
|
GO:0005509; GO:0005543; GO:0005576; GO:0006644; GO:0016042; GO:0042130; GO:0047498; GO:0050482; GO:0090729
|
Evidence at protein level
| 5 |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23509754}.
| null | null |
PF00068;
|
IPR001211;IPR033112;IPR016090;IPR036444;IPR033113;
| null |
cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Lepidosauria (class), Squamata (order), Bifurcata (clade), Unidentata (clade), Episquamata (clade), Toxicofera (clade), Serpentes (infraorder), Colubroidea (superfamily), Viperidae (family), Crotalinae (subfamily), Bothrops (genus), Bothrops bilineatus (species)
| null | true |
Bothrops bilineatus
| 0 |
row_326
| false | null |
1,358 |
P06200
|
MTENWKFRRRTFLKHGAQAATLAGLSGLFPETLRRALAVEPDIRTGTIQDVQHVVILMQENRSFDHYFGHLNGVRGFNDPRALKRQDGKPVWYQNYKYEFSPYHWDTKVTSAQWVSSQNHEWSAFHAIWNQGRNDKWMAVQYPEAMGYFKRGDIPYYYALADAFTLCEAYHQSMMGPTNPNRLYHMSGRAAPSGDGKDVHIGNDMGDGTIGASGTVDWTTYPERLSAAGVDWRVYQEGGYRSSSLWYLYVDAYWKYRLQEQNNYDCNALAWFRNFKNAPRDSDLWQRAMLARGVDQLRKDVQENTLPQVSWIVAPYCYCEHPWWGPSFGEYYVTRVLEALTSNPEVWARTVFILNYDEGDGFYDHASAPVPPWKDGVGLSTVSTAGEIEVSSGLPIGLGHRVPLIAISPWSKGGKVSAEVFDHTSVLRFLERRFGVVEENISPWRRAVCGDLTSLFDFQGAGDTQVAPDLTNVPQSDARKEDAYWQQFYRPSPKYWSYEPKSLPGQEKGQRPTLAVPYQLHATLALDIAAGKLRLTLGNDGMSLPGNPQGHSAAVFQVQPREVGNPRFYTVTSYPVVQESGEELGRTLNDELDDLLDANGRYAFEVHGPNGFFREFHGNLHLAAQMARPEVSVTYQRNGNLQLNIRNLGRLPCSVTVTPNPAYTREGSRRYELEPNQAISEVWLLRSSQGWYDLSVTASNTEANYLRRLAGHVETGKPSRSDPLLDIAAT
|
Hemolytic phospholipase C (EC 3.1.4.3) (Heat-labile hemolysin) (PLC-H) (Phosphatidylcholine cholinephosphohydrolase)
|
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
| 208,964 | 730 | 82,667 |
Cytolysis;Hemolysis;Hydrolase;Reference proteome;Signal;Toxin;Virulence
|
GO:0005615; GO:0015628; GO:0016042; GO:0016298; GO:0033188; GO:0034480; GO:0044179; GO:0090729
|
Inferred from homology
| 4 | null |
SIGNAL 1..38; /note="Tat-type signal"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00648"
| null |
PF04185;PF05506;
|
IPR017850;IPR017767;IPR007312;IPR008475;IPR006311;
| null |
cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Gammaproteobacteria (class), Pseudomonadales (order), Pseudomonadaceae (family), Pseudomonas (genus), Pseudomonas aeruginosa group (no rank), Pseudomonas aeruginosa (species)
|
plcH PA0844
| true |
Pseudomonas aeruginosa
| 0 |
row_1299
| false | null |
361 |
P11439
|
MHLTPHWIPLVASLGLLAGGSFASAAEEAFDLWNECAKACVLDLKDGVRSSRMSVDPAIADTNGQGVLHYSMVLEGGNDALKLAIDNALSITSDGLTIRLEGGVEPNKPVRYSYTRQARGSWSLNWLVPIGHEKPSNIKVFIHELNAGNQLSHMSPIYTIEMGDELLAKLARDATFFVRAHESNEMQPTLAISHAGVSVVMAQAQPRREKRWSEWASGKVLCLLDPLDGVYNYLAQQRCNLDDTWEGKIYRVLAGNPAKHDLDIKPTVISHRLHFPEGGSLAALTAHQACHLPLETFTRHRQPRGWEQLEQCGYPVQRLVALYLAARLSWNQVDQVIRNALASPGSGGDLGEAIREQPEQARLALTLAAAESERFVRQGTGNDEAGAASADVVSLTCPVAAGECAGPADSGDALLERNYPTGAEFLGDGGDISFSTRGTQNWTVERLLQAHRQLEERGYVFVGYHGTFLEAAQSIVFGGVRARSQDLDAIWRGFYIAGDPALAYGYAQDQEPDARGRIRNGALLRVYVPRSSLPGFYRTGLTLAAPEAAGEVERLIGHPLPLRLDAITGPEEEGGRLETILGWPLAERTVVIPSAIPTDPRNVGGDLDPSSIPDKEQAISALPDYASQPGKPPREDLK
|
Exotoxin A (ETA) (EC 2.4.2.36) (NAD(+)--diphthamide ADP-ribosyltransferase) (Pseudomonas exotoxin) (PE)
|
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
| 208,964 | 638 | 69,284 |
3D-structure;Direct protein sequencing;Disulfide bond;Glycosyltransferase;NAD;Nucleotidyltransferase;Reference proteome;Signal;Toxin;Transferase;Virulence
|
GO:0001907; GO:0016779; GO:0047286; GO:0090729; GO:0141155
|
Evidence at protein level
| 5 | null |
SIGNAL 1..25; /evidence="ECO:0000269|PubMed:6201861"
| null |
PF09101;PF09009;PF09102;
|
IPR013320;IPR015185;IPR015099;IPR015186;IPR036478;
|
1AER;1DMA;1IKP;1IKQ;1XK9;1ZM2;1ZM3;1ZM4;1ZM9;2ZIT;3B78;3B82;3B8H;
|
cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Gammaproteobacteria (class), Pseudomonadales (order), Pseudomonadaceae (family), Pseudomonas (genus), Pseudomonas aeruginosa group (no rank), Pseudomonas aeruginosa (species)
|
eta PA1148
| true |
Pseudomonas aeruginosa
| 1 |
row_334
| false | null |
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