sentence
stringlengths 9
1.35k
| relations
listlengths 1
26
| dataset
stringclasses 18
values | types
listlengths 1
24
|
|---|---|---|---|
None of them had a history of cardiac disease , and with the possible exception of one case of cardiac arrest , where the patient received doxorubicin , no predisposing factors could be found .
|
[
{
"head": {
"name": "cardiac arrest",
"pos": [],
"type": ""
},
"tail": {
"name": "doxorubicin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Visceral herpesvirus infections in leukemic patients receiving cytarabine .
|
[
{
"head": {
"name": "Visceral herpesvirus infections",
"pos": [],
"type": ""
},
"tail": {
"name": "cytarabine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
A 43-year - old woman with multiple sclerosis ( MS ) had nephrotic syndrome 21 months after starting treatment with interferon ( IFN ) - beta-1b ( subcutaneous administration ) .
|
[
{
"head": {
"name": "nephrotic syndrome",
"pos": [],
"type": ""
},
"tail": {
"name": "interferon ( IFN ) - beta-1b",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We report an HIV - infected woman who developed mild leukopenia as the first sign of a nevirapine - related adverse event , which was followed by skin and hepatic toxicity associated with a more severe leukopenia .
|
[
{
"head": {
"name": "leukopenia",
"pos": [],
"type": ""
},
"tail": {
"name": "nevirapine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "leukopenia",
"pos": [],
"type": ""
},
"tail": {
"name": "nevirapine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "skin and hepatic toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "nevirapine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine .
|
[
{
"head": {
"name": "Systemic vasculitis",
"pos": [],
"type": ""
},
"tail": {
"name": "cladribine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The NZ Pharmacovigilance Centre has received 7 additional reports of severe infections in patients with RA taking leflunomide .
|
[
{
"head": {
"name": "severe infections",
"pos": [],
"type": ""
},
"tail": {
"name": "leflunomide",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Ten to 15 % of patients treated with ifosfamide develop an encephalopathy .
|
[
{
"head": {
"name": "encephalopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "ifosfamide",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Hyperpigmentation during interferon - alpha therapy for chronic hepatitis C virus infection .
|
[
{
"head": {
"name": "Hyperpigmentation",
"pos": [],
"type": ""
},
"tail": {
"name": "interferon - alpha",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We describe a 74-year - old man with rheumatoid arthritis ( RA ) who developed syndrome of inappropriate secretion of antidiuretic hormone ( SIADH ) 1.5 months after commencement of mizoribin prescription when his arthritis was improved .
|
[
{
"head": {
"name": "SIADH",
"pos": [],
"type": ""
},
"tail": {
"name": "mizoribin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "syndrome of inappropriate secretion of antidiuretic hormone",
"pos": [],
"type": ""
},
"tail": {
"name": "mizoribin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The HIV protease inhibitor indinavir may cause nephrolithiasis and interstitial nephritis .
|
[
{
"head": {
"name": "interstitial nephritis",
"pos": [],
"type": ""
},
"tail": {
"name": "indinavir",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "nephrolithiasis",
"pos": [],
"type": ""
},
"tail": {
"name": "indinavir",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Trimethoprim - sulfamethoxazole - induced hypersensitivity syndrome associated with reactivation of human herpesvirus-6 .
|
[
{
"head": {
"name": "hypersensitivity syndrome",
"pos": [],
"type": ""
},
"tail": {
"name": "Trimethoprim - sulfamethoxazole",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Herein , we present a patient with severe and prolonged hypoglycemia after long - acting octreotide treatment .
|
[
{
"head": {
"name": "prolonged hypoglycemia",
"pos": [],
"type": ""
},
"tail": {
"name": "octreotide",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Soon after introduction of insulin therapy , she developed severe anasarca , including marked peripheral oedema , ascites and pleural effusion .
|
[
{
"head": {
"name": "ascites",
"pos": [],
"type": ""
},
"tail": {
"name": "insulin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "peripheral oedema",
"pos": [],
"type": ""
},
"tail": {
"name": "insulin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "pleural effusion",
"pos": [],
"type": ""
},
"tail": {
"name": "insulin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "severe anasarca",
"pos": [],
"type": ""
},
"tail": {
"name": "insulin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Caution with use of cimetidine in tolazoline induced upper gastrointestinal bleeding .
|
[
{
"head": {
"name": "upper gastrointestinal bleeding",
"pos": [],
"type": ""
},
"tail": {
"name": "cimetidine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "upper gastrointestinal bleeding",
"pos": [],
"type": ""
},
"tail": {
"name": "tolazoline",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy .
|
[
{
"head": {
"name": "Hemorrhagic cystitis",
"pos": [],
"type": ""
},
"tail": {
"name": "cyclophosphamide",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Hyperkalemia as a late side effect of prolonged adrenocorticotropic hormone therapy for infantile spasms .
|
[
{
"head": {
"name": "Hyperkalemia",
"pos": [],
"type": ""
},
"tail": {
"name": "adrenocorticotropic hormone",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We report the case of a patient with increased cerebral cortical excitability following intoxication with flupirtine , a centrally acting analgesic and antispastic drug .
|
[
{
"head": {
"name": "increased cerebral cortical excitability",
"pos": [],
"type": ""
},
"tail": {
"name": "flupirtine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms , particularly fever , rash , and lymphadenopathy .
|
[
{
"head": {
"name": "fever",
"pos": [],
"type": ""
},
"tail": {
"name": "phenytoin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "fever",
"pos": [],
"type": ""
},
"tail": {
"name": "phenytoin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "hypersensitivity reactions",
"pos": [],
"type": ""
},
"tail": {
"name": "phenytoin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "hypersensitivity reactions",
"pos": [],
"type": ""
},
"tail": {
"name": "phenytoin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "lymphadenopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "phenytoin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "lymphadenopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "phenytoin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "rash",
"pos": [],
"type": ""
},
"tail": {
"name": "phenytoin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "rash",
"pos": [],
"type": ""
},
"tail": {
"name": "phenytoin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
A case is reported of theophylline intoxication due to a dramatic decrease in theophylline clearance following concomitant administration of viloxazine .
|
[
{
"head": {
"name": "decrease in theophylline clearance",
"pos": [],
"type": ""
},
"tail": {
"name": "viloxazine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "theophylline intoxication",
"pos": [],
"type": ""
},
"tail": {
"name": "theophylline",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "theophylline intoxication",
"pos": [],
"type": ""
},
"tail": {
"name": "viloxazine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Suxamethonium apnoea terminated with commercial serumcholinesterase .
|
[
{
"head": {
"name": "apnoea",
"pos": [],
"type": ""
},
"tail": {
"name": "Suxamethonium",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
There have been numerous case reports of hyperglycemia with olanzapine in the literature , but none reported hyperglycemia within days of initiation of the medication .
|
[
{
"head": {
"name": "hyperglycemia",
"pos": [],
"type": ""
},
"tail": {
"name": "olanzapine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
OBJECTIVE : To describe onset of syndrome of inappropriate antidiuretic hormone ( SIADH ) associated with vinorelbine therapy for advanced breast cancer .
|
[
{
"head": {
"name": "SIADH",
"pos": [],
"type": ""
},
"tail": {
"name": "vinorelbine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "syndrome of inappropriate antidiuretic hormone",
"pos": [],
"type": ""
},
"tail": {
"name": "vinorelbine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Stroke - like syndrome after gold sodium thiomalate induced vasomotor reaction .
|
[
{
"head": {
"name": "Stroke - like syndrome",
"pos": [],
"type": ""
},
"tail": {
"name": "gold sodium thiomalate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "vasomotor reaction",
"pos": [],
"type": ""
},
"tail": {
"name": "gold sodium thiomalate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
This report describes an unexpected drug - induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate .
|
[
{
"head": {
"name": "hepatitis",
"pos": [],
"type": ""
},
"tail": {
"name": "amodiaquine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "hepatitis",
"pos": [],
"type": ""
},
"tail": {
"name": "artesunate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Visual loss after a single small dose of vincristine has never been reported .
|
[
{
"head": {
"name": "Visual loss",
"pos": [],
"type": ""
},
"tail": {
"name": "vincristine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Abnormal retinal function associated with isotretinoin therapy for acne .
|
[
{
"head": {
"name": "Abnormal retinal function",
"pos": [],
"type": ""
},
"tail": {
"name": "isotretinoin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss .
|
[
{
"head": {
"name": "sensorineural hearing loss",
"pos": [],
"type": ""
},
"tail": {
"name": "methotrexate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "sensorineural hearing loss",
"pos": [],
"type": ""
},
"tail": {
"name": "PAN",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We report a 4-year - old girl who presented with acute bilateral blindness , a focal seizure and hypertension 10 days after commencing oxybutynin to treat enuresis .
|
[
{
"head": {
"name": "acute bilateral blindness",
"pos": [],
"type": ""
},
"tail": {
"name": "oxybutynin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "focal seizure",
"pos": [],
"type": ""
},
"tail": {
"name": "oxybutynin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "hypertension",
"pos": [],
"type": ""
},
"tail": {
"name": "oxybutynin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Skin rash began after 2 weeks of treatment , and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started .
|
[
{
"head": {
"name": "hepatocellular failure",
"pos": [],
"type": ""
},
"tail": {
"name": "phenobarbital",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Skin rash",
"pos": [],
"type": ""
},
"tail": {
"name": "phenobarbital",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Severe hepatocellular dysfunction following cyproterone acetate therapy .
|
[
{
"head": {
"name": "Severe hepatocellular dysfunction",
"pos": [],
"type": ""
},
"tail": {
"name": "cyproterone acetate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Severe leukopenia associated with mild hepatotoxicity in an HIV carrier treated with nevirapine .
|
[
{
"head": {
"name": "mild hepatotoxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "nevirapine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Severe leukopenia",
"pos": [],
"type": ""
},
"tail": {
"name": "nevirapine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
A case of a 21-year - old woman who had developed mild hepatotoxicity while receiving choline magnesium trisalicylate therapy is described .
|
[
{
"head": {
"name": "hepatotoxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "choline magnesium trisalicylate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Corneal edema recurred when the administration of amantadine was resumed .
|
[
{
"head": {
"name": "Corneal edema",
"pos": [],
"type": ""
},
"tail": {
"name": "amantadine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis , immediate withdrawal of amiodarone , and prompt but continued steroid therapy to ensure full recovery .
|
[
{
"head": {
"name": "pneumonitis",
"pos": [],
"type": ""
},
"tail": {
"name": "amiodarone",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Case report : mannitol nephrotoxicity syndrome : role of hemodialysis and postulate of mechanisms .
|
[
{
"head": {
"name": "nephrotoxicity syndrome",
"pos": [],
"type": ""
},
"tail": {
"name": "mannitol",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
OBJECTIVES : A delayed stroke - like leukoencephalopathy has been observed in patients receiving methotrexate ( MTX ) for childhood leukemia .
|
[
{
"head": {
"name": "stroke - like leukoencephalopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "methotrexate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "stroke - like leukoencephalopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "MTX",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
This case demonstrates the association of selective IgA deficiency with remission in rheumatoid arthritis induced by fenclofenac as well as aurothiomalate and sulphasalazine .
|
[
{
"head": {
"name": "IgA deficiency",
"pos": [],
"type": ""
},
"tail": {
"name": "aurothiomalate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "IgA deficiency",
"pos": [],
"type": ""
},
"tail": {
"name": "fenclofenac",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "IgA deficiency",
"pos": [],
"type": ""
},
"tail": {
"name": "sulphasalazine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
An adult male presented with central blindness after ingesting methanol .
|
[
{
"head": {
"name": "central blindness",
"pos": [],
"type": ""
},
"tail": {
"name": "methanol",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV - associated lymphoproliferative disease .
|
[
{
"head": {
"name": "EBV - associated lymphoproliferative disease",
"pos": [],
"type": ""
},
"tail": {
"name": "MTX",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "hematopoietic toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "MTX",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "immunosuppression",
"pos": [],
"type": ""
},
"tail": {
"name": "MTX",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
A patient with acute esophageal variceal bleeding developed fatal rhabdomyolysis during treatment with a continuous intravenous infusion of vasopressin .
|
[
{
"head": {
"name": "fatal rhabdomyolysis",
"pos": [],
"type": ""
},
"tail": {
"name": "vasopressin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The most serious dental side effect of bisphosphonate treatment ( particularly when it is administered intravenously ) is , paradoxically , osteonecrosis of the mandible or the maxilla represented by exposed nonhealing bone .
|
[
{
"head": {
"name": "osteonecrosis of the mandible",
"pos": [],
"type": ""
},
"tail": {
"name": "bisphosphonate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days , respectively , following a single dose of 40 mg / m2 methotrexate ( MTX ) .
|
[
{
"head": {
"name": "bone marrow aplasia",
"pos": [],
"type": ""
},
"tail": {
"name": "methotrexate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "bone marrow aplasia",
"pos": [],
"type": ""
},
"tail": {
"name": "MTX",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "severe skin rash",
"pos": [],
"type": ""
},
"tail": {
"name": "methotrexate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "severe skin rash",
"pos": [],
"type": ""
},
"tail": {
"name": "MTX",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Skin rash and splinter hemorrhages from ganciclovir .
|
[
{
"head": {
"name": "Skin rash",
"pos": [],
"type": ""
},
"tail": {
"name": "ganciclovir",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "splinter hemorrhages",
"pos": [],
"type": ""
},
"tail": {
"name": "ganciclovir",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
A 21-year - old man with Tourette 's syndrome , pedophilia , Asperger 's syndrome , and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a .
|
[
{
"head": {
"name": "seizures",
"pos": [],
"type": ""
},
"tail": {
"name": "interferon beta-1a",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
However , a new episode of neutropenia , with a WBC count of 2.8 x 10(3)/mm3 and ANC of 0.448 x 10(3)/mm3 , occurred 11 days after teicoplanin initiation .
|
[
{
"head": {
"name": "neutropenia",
"pos": [],
"type": ""
},
"tail": {
"name": "teicoplanin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Total blindness with a transient tonic pupillary response , denervation supersensitivity , and abnormal visual - evoked potentials developed in a 54-year - old man after the use of quinine sulfate for leg cramps .
|
[
{
"head": {
"name": "abnormal visual - evoked potentials",
"pos": [],
"type": ""
},
"tail": {
"name": "quinine sulfate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "denervation supersensitivity",
"pos": [],
"type": ""
},
"tail": {
"name": "quinine sulfate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Total blindness with a transient tonic pupillary response",
"pos": [],
"type": ""
},
"tail": {
"name": "quinine sulfate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
In three of these patients the infection was clinically unsuspected ; in the fourth , cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days .
|
[
{
"head": {
"name": "cutaneous herpes zoster",
"pos": [],
"type": ""
},
"tail": {
"name": "cytarabine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Excluding other causes , Pentasa - associated pancytopenia was considered .
|
[
{
"head": {
"name": "pancytopenia",
"pos": [],
"type": ""
},
"tail": {
"name": "Pentasa",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
PURPOSE : To determine the cause of spontaneous choroidal hemorrhage in a 67-year - old man after a myocardial infarction and administration of tissue plasminogen activator .
|
[
{
"head": {
"name": "spontaneous choroidal hemorrhage",
"pos": [],
"type": ""
},
"tail": {
"name": "tissue plasminogen activator",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We report a case of sustained hypotension after administration of parenteral verapamil .
|
[
{
"head": {
"name": "sustained hypotension",
"pos": [],
"type": ""
},
"tail": {
"name": "verapamil",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Acute neutrophilic dermatosis induced by all - trans - retinoic acid treatment for acute promyelocytic leukemia .
|
[
{
"head": {
"name": "Acute neutrophilic dermatosis",
"pos": [],
"type": ""
},
"tail": {
"name": "all - trans - retinoic acid",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Management of hypophosphatemia induced by high - flux hemodiafiltration for the treatment of vancomycin toxicity : intravenous phosphorus therapy versus use of a phosphorus - enriched dialysate .
|
[
{
"head": {
"name": "vancomycin toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "vancomycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
After three weeks of carbamazepine therapy , the patient arrived at the emergency department ( ED ) with severe agitation and aggressive behavior .
|
[
{
"head": {
"name": "aggressive behavior",
"pos": [],
"type": ""
},
"tail": {
"name": "carbamazepine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "severe agitation",
"pos": [],
"type": ""
},
"tail": {
"name": "carbamazepine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Ceftriaxone was approved in 1997 for the treatment of otitis media despite previous studies that documented an association of ceftriaxone with elevated hepato - biliary enzymes and transient biliary stasis .
|
[
{
"head": {
"name": "elevated hepato - biliary enzymes",
"pos": [],
"type": ""
},
"tail": {
"name": "ceftriaxone",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "transient biliary stasis",
"pos": [],
"type": ""
},
"tail": {
"name": "ceftriaxone",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Dyspnea , hypoxemia , and pleuritic chest pain occurred within 24 hours of rituximab administration , and there was no other apparent explanation .
|
[
{
"head": {
"name": "Dyspnea",
"pos": [],
"type": ""
},
"tail": {
"name": "rituximab",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "hypoxemia",
"pos": [],
"type": ""
},
"tail": {
"name": "rituximab",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "pleuritic chest pain",
"pos": [],
"type": ""
},
"tail": {
"name": "rituximab",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Hypersensitivity to carboplatin has been reported in up to 44 % of patients receiving this antineoplastic agent , usually occurring after several courses of treatment .
|
[
{
"head": {
"name": "Hypersensitivity",
"pos": [],
"type": ""
},
"tail": {
"name": "carboplatin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
This is the first case of TMP - SMX - induced hypersensitivity syndrome associated with the reactivation of a latent viral infection .
|
[
{
"head": {
"name": "hypersensitivity syndrome",
"pos": [],
"type": ""
},
"tail": {
"name": "TMP - SMX",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
CASES : " A " was an 8-year - old boy with attention deficit and chronic tic disorder who developed obsessive - compulsive symptoms within 2 weeks of starting risperidone .
|
[
{
"head": {
"name": "obsessive - compulsive symptoms",
"pos": [],
"type": ""
},
"tail": {
"name": "risperidone",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Acute renal failure following intravenous immunoglobulin therapy in a HIV - infected patient .
|
[
{
"head": {
"name": "Acute renal failure",
"pos": [],
"type": ""
},
"tail": {
"name": "immunoglobulin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Concomitant administration of lithium with olanzapine may place patients at risk for NMS .
|
[
{
"head": {
"name": "NMS",
"pos": [],
"type": ""
},
"tail": {
"name": "lithium",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "NMS",
"pos": [],
"type": ""
},
"tail": {
"name": "olanzapine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Flaccid quadriparesis was noted after discontinuation of vecuronium .
|
[
{
"head": {
"name": "Flaccid quadriparesis",
"pos": [],
"type": ""
},
"tail": {
"name": "vecuronium",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
In this paper , we report a case of severe hypercalcemia of immobilization in a 40-year - old hemodialyzed woman treated by cinacalcet HCl for a severe HPTH - II ( PTH>1,000 pg / mL ) .
|
[
{
"head": {
"name": "severe hypercalcemia",
"pos": [],
"type": ""
},
"tail": {
"name": "cinacalcet HCl",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Based upon the observed fall of the filtration fraction , the rise in the relative clearance of 99Tc - dimercaptosuccinic acid and the increase in proteinuria , we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity .
|
[
{
"head": {
"name": "fall of the filtration fraction",
"pos": [],
"type": ""
},
"tail": {
"name": "cyclosporine A",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "increase in proteinuria",
"pos": [],
"type": ""
},
"tail": {
"name": "cyclosporine A",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "nephrotoxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "cyclosporine A",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "rise in the relative clearance of 99Tc - dimercaptosuccinic acid",
"pos": [],
"type": ""
},
"tail": {
"name": "cyclosporine A",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Therefore , parenteral amiodarone was implicated as the cause of acute hepatitis in this patient .
|
[
{
"head": {
"name": "acute hepatitis",
"pos": [],
"type": ""
},
"tail": {
"name": "amiodarone",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The mean time from starting MMF to the development of neutropenia was 4 months .
|
[
{
"head": {
"name": "neutropenia",
"pos": [],
"type": ""
},
"tail": {
"name": "MMF",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis , respectively , in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other .
|
[
{
"head": {
"name": "necrotizing vasculitis",
"pos": [],
"type": ""
},
"tail": {
"name": "infliximab",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "peripheral neuropathy",
"pos": [],
"type": ""
},
"tail": {
"name": "infliximab",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "progression of preexisting mononeuritis multiplex",
"pos": [],
"type": ""
},
"tail": {
"name": "infliximab",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Administration of cisplatin in three patients with carboplatin hypersensitivity : is skin testing useful ?
|
[
{
"head": {
"name": "hypersensitivity",
"pos": [],
"type": ""
},
"tail": {
"name": "carboplatin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug - induced liver injury .
|
[
{
"head": {
"name": "hepatitis",
"pos": [],
"type": ""
},
"tail": {
"name": "IFN beta",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "liver injury",
"pos": [],
"type": ""
},
"tail": {
"name": "IFN beta",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Actinomycin D associated hepatic veno - occlusive disease -- a report of 2 cases .
|
[
{
"head": {
"name": "hepatic veno - occlusive disease",
"pos": [],
"type": ""
},
"tail": {
"name": "Actinomycin D",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Mannitol - induced ARF responds promptly to hemodialysis with rapid resolution of anuria and recovery of renal failure .
|
[
{
"head": {
"name": "ARF",
"pos": [],
"type": ""
},
"tail": {
"name": "Mannitol",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
OBJECTIVE : To report a case of Carbamazepine toxicity following the administration of Oxybutynin and Dantrolene .
|
[
{
"head": {
"name": "Carbamazepine toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "Carbamazepine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Carbamazepine toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "Dantrolene",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Carbamazepine toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "Oxybutynin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Vasomotor reactions after gold sodium thiomalate are well recognized .
|
[
{
"head": {
"name": "Vasomotor reactions",
"pos": [],
"type": ""
},
"tail": {
"name": "gold sodium thiomalate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Possible mechanisms by which clonidine decreases spasticity are described , probable mechanisms of induced bradycardia are reviewed , and specific treatment recommendations for the use of clonidine in spinal cord injured patients are presented .
|
[
{
"head": {
"name": "bradycardia",
"pos": [],
"type": ""
},
"tail": {
"name": "clonidine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "bradycardia",
"pos": [],
"type": ""
},
"tail": {
"name": "clonidine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We report the case of a patient with the acquired immunodeficiency syndrome treated with rifampicin who had a ' normal ' screening test for adrenal insufficiency , yet had clinical evidence of adrenal failure .
|
[
{
"head": {
"name": "adrenal failure",
"pos": [],
"type": ""
},
"tail": {
"name": "rifampicin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin , with severe toxicity .
|
[
{
"head": {
"name": "delayed elimination",
"pos": [],
"type": ""
},
"tail": {
"name": "ciprofloxacin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "delayed elimination",
"pos": [],
"type": ""
},
"tail": {
"name": "methotrexate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "ciprofloxacin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The toxicity and plasma concentrations of ifosfamide , chloroacetaldehyde , and 4-hydroxyifosfamide were then determined over 24 h after a single 1.6 g / m2 dose of ifosfamide .
|
[
{
"head": {
"name": "toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "4-hydroxyifosfamide",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "chloroacetaldehyde",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "ifosfamide",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "ifosfamide",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Two other patients who did not receive prochlorperazine , developed retinal problems which later improved , one after only 15 g of desferrioxamine .
|
[
{
"head": {
"name": "retinal problems",
"pos": [],
"type": ""
},
"tail": {
"name": "desferrioxamine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Amoxapine - induced cognitive impairment in two patients .
|
[
{
"head": {
"name": "cognitive impairment",
"pos": [],
"type": ""
},
"tail": {
"name": "Amoxapine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Severe serotonin syndrome induced by mirtazapine monotherapy .
|
[
{
"head": {
"name": "serotonin syndrome",
"pos": [],
"type": ""
},
"tail": {
"name": "mirtazapine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
An 11-year - old boy who was treated with a relatively high dose of methotrimeprazine meleate ( Levemepromazine ) a phenothiazine antipsychotic drug , was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome .
|
[
{
"head": {
"name": "respiratory distress syndrome",
"pos": [],
"type": ""
},
"tail": {
"name": "Levemepromazine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "respiratory distress syndrome",
"pos": [],
"type": ""
},
"tail": {
"name": "methotrimeprazine meleate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Propylthiouracil - induced cutaneous vasculitis .
|
[
{
"head": {
"name": "cutaneous vasculitis",
"pos": [],
"type": ""
},
"tail": {
"name": "Propylthiouracil",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Fatal ventricular fibrillation after treatment with digoxin in a 27-year - old man with mitral leaflet prolapse syndrome .
|
[
{
"head": {
"name": "Fatal ventricular fibrillation",
"pos": [],
"type": ""
},
"tail": {
"name": "digoxin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Traumatic late flap dehiscence and Enterobacter keratitis following LASIK .
|
[
{
"head": {
"name": "Enterobacter keratitis",
"pos": [],
"type": ""
},
"tail": {
"name": "LASIK",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Traumatic late flap dehiscence",
"pos": [],
"type": ""
},
"tail": {
"name": "LASIK",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
CONCLUSIONS : Infectious endophthalmitis is a potential complication of intravitreal bevacizumab injection .
|
[
{
"head": {
"name": "Infectious endophthalmitis",
"pos": [],
"type": ""
},
"tail": {
"name": "bevacizumab",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We present the first case of a patient with priapism after oral intake of the phenothiazine prothipendylhydrochloride .
|
[
{
"head": {
"name": "priapism",
"pos": [],
"type": ""
},
"tail": {
"name": "prothipendylhydrochloride",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
One case of tacrolimus - induced hepatic VOD developing after lung transplantation ( LT ) has been recently reported .
|
[
{
"head": {
"name": "hepatic VOD",
"pos": [],
"type": ""
},
"tail": {
"name": "tacrolimus",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy .
|
[
{
"head": {
"name": "fatal pulmonary fibrosis",
"pos": [],
"type": ""
},
"tail": {
"name": "BCNU",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Exfoliative dermatitis secondary to tobramycin sulfate .
|
[
{
"head": {
"name": "Exfoliative dermatitis",
"pos": [],
"type": ""
},
"tail": {
"name": "tobramycin sulfate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We describe a case of ulcerative proctitis after ibuprofen treatment in a girl with juvenile systemic lupus erythematosus .
|
[
{
"head": {
"name": "ulcerative proctitis",
"pos": [],
"type": ""
},
"tail": {
"name": "ibuprofen",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
ARDS is rarely associated with rituximab infusion for lympho - proliferative disorders , but it should be considered by those administering rituximab , especially when a patient develops severe pulmonary symptoms soon after infusion .
|
[
{
"head": {
"name": "ARDS",
"pos": [],
"type": ""
},
"tail": {
"name": "rituximab",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "ARDS",
"pos": [],
"type": ""
},
"tail": {
"name": "rituximab",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "severe pulmonary symptoms",
"pos": [],
"type": ""
},
"tail": {
"name": "rituximab",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Ophthalmologic and neurologic findings in two children exposed to vigabatrin in utero .
|
[
{
"head": {
"name": "Ophthalmologic and neurologic findings",
"pos": [],
"type": ""
},
"tail": {
"name": "vigabatrin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoproliferative diseases , but coincidence can not be excluded .
|
[
{
"head": {
"name": "lymphoproliferative diseases",
"pos": [],
"type": ""
},
"tail": {
"name": "methotrexate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We present a case of a 58-year - old female patient with Graves ' disease who developed AA in the third exposure to methimazole ( MMI ) .
|
[
{
"head": {
"name": "AA",
"pos": [],
"type": ""
},
"tail": {
"name": "methimazole",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Cyclosporine - induced pain syndrome in a child undergoing hematopoietic stem cell transplant .
|
[
{
"head": {
"name": "pain syndrome",
"pos": [],
"type": ""
},
"tail": {
"name": "Cyclosporine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
After initiation of topical vitamin D3 ointment ( 20 micro g / g of tacalcitol ) 10 g / day for the skin lesions , both the serum level of calcium and urinary excretion of calcium increased gradually .
|
[
{
"head": {
"name": "serum level of calcium and urinary excretion of calcium increased",
"pos": [],
"type": ""
},
"tail": {
"name": "vitamin D3",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We conclude that neurosurgeons and neurologists should be aware of calcium antagonist -- related ileus in patients treated with nimodipine .
|
[
{
"head": {
"name": "ileus",
"pos": [],
"type": ""
},
"tail": {
"name": "nimodipine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Acetazolamide - accelerated anticonvulsant osteomalacia .
|
[
{
"head": {
"name": "osteomalacia",
"pos": [],
"type": ""
},
"tail": {
"name": "Acetazolamide",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Vigabatrin - induced visual field defects are at present the most important safety issue in the use of the drug .
|
[
{
"head": {
"name": "visual field defects",
"pos": [],
"type": ""
},
"tail": {
"name": "Vigabatrin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Prior to surgery , levodopa induced dyskinesia had improved ( < or = 50 % ) under treatment with amantadine ( 400 mg / day , po ) in all three patients .
|
[
{
"head": {
"name": "dyskinesia",
"pos": [],
"type": ""
},
"tail": {
"name": "levodopa",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Hemodialysis was also shown to reverse ifosfamide - related neurotoxicity .
|
[
{
"head": {
"name": "neurotoxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "ifosfamide",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
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