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Isoniazid associated , painful , bilateral gynaecomastia .
[ { "head": { "name": "bilateral gynaecomastia", "pos": [], "type": "" }, "tail": { "name": "Isoniazid", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Sixteen of 33 patients developed significant hyponatremia and hypoosmolality during oral treatment with lorcainide .
[ { "head": { "name": "hyponatremia", "pos": [], "type": "" }, "tail": { "name": "lorcainide", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hypoosmolality", "pos": [], "type": "" }, "tail": { "name": "lorcainide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn .
[ { "head": { "name": "field defects", "pos": [], "type": "" }, "tail": { "name": "vigabatrin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Haemolytic - uraemic syndrome complicating long - term mitomycin C and 5-fluorouracil therapy for gastric carcinoma .
[ { "head": { "name": "Haemolytic - uraemic syndrome", "pos": [], "type": "" }, "tail": { "name": "5-fluorouracil", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "Haemolytic - uraemic syndrome", "pos": [], "type": "" }, "tail": { "name": "mitomycin C", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring .
[ { "head": { "name": "ethambutol toxicity", "pos": [], "type": "" }, "tail": { "name": "ethambutol", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "vision loss", "pos": [], "type": "" }, "tail": { "name": "ethambutol", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The oligohidrosis caused by zonisamide was reversible in that the patient regained the ability to sweat within 2 weeks of the cessation of drug administration .
[ { "head": { "name": "oligohidrosis", "pos": [], "type": "" }, "tail": { "name": "zonisamide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer , in which the pneumonitis was successfully managed by steroid treatment .
[ { "head": { "name": "interstitial pneumonitis", "pos": [], "type": "" }, "tail": { "name": "bicalutamide", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "interstitial pneumonitis", "pos": [], "type": "" }, "tail": { "name": "leuprorelin acetate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A 60-year - old woman with diabetes mellitus ( type 2 ) developed an acute icteric hepatitis - like illness 6 weeks after the initiation of gliclazide therapy .
[ { "head": { "name": "acute icteric hepatitis - like illness", "pos": [], "type": "" }, "tail": { "name": "gliclazide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment .
[ { "head": { "name": "lactate elevation", "pos": [], "type": "" }, "tail": { "name": "metronidazole", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
PURPOSE : To report a case of angiographically documented cystoid macula edema occurring after switching a pseudophakic patient from latanoprost to bimatoprost .
[ { "head": { "name": "cystoid macula edema", "pos": [], "type": "" }, "tail": { "name": "bimatoprost", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "cystoid macula edema", "pos": [], "type": "" }, "tail": { "name": "latanoprost", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report the case of a 20-year - old female with polyarteritis nodosa ( PAN ) who developed bilateral sensorineural hearing loss 25 minutes after receiving 30 mg of intravenous ketoralac .
[ { "head": { "name": "bilateral sensorineural hearing loss", "pos": [], "type": "" }, "tail": { "name": "ketoralac", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We reviewed the records of 3 patients with lymphoproliferative disorders who experienced acute coronary syndromes associated with their initial infusion of rituximab .
[ { "head": { "name": "acute coronary syndromes", "pos": [], "type": "" }, "tail": { "name": "rituximab", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
At the end of his fifth cycle of sunitinib therapy , the patient complained of the development of abnormally large mammary glands associated with pain and peri - areolar erythema .
[ { "head": { "name": "development of abnormally large mammary glands", "pos": [], "type": "" }, "tail": { "name": "sunitinib", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "pain", "pos": [], "type": "" }, "tail": { "name": "sunitinib", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "peri - areolar erythema", "pos": [], "type": "" }, "tail": { "name": "sunitinib", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Therefore , amantadine was permanently discontinued and the cornea cleared again .
[ { "head": { "name": "cornea", "pos": [], "type": "" }, "tail": { "name": "amantadine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Here we describe a patient with Crohn 's disease who developed a severe infliximab infusion reaction ( IIR ) , complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion .
[ { "head": { "name": "IIR", "pos": [], "type": "" }, "tail": { "name": "infliximab", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "IIR", "pos": [], "type": "" }, "tail": { "name": "infliximab", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "severe infliximab infusion reaction", "pos": [], "type": "" }, "tail": { "name": "infliximab", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "severe infliximab infusion reaction", "pos": [], "type": "" }, "tail": { "name": "infliximab", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "severe swelling of the forearm and hand ipsilateral", "pos": [], "type": "" }, "tail": { "name": "infliximab", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "severe swelling of the forearm and hand ipsilateral", "pos": [], "type": "" }, "tail": { "name": "infliximab", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We present a pediatric patient with leukemia and a severe , L - asparaginase - induced necrotizing pancreatitis , treated successfully with percutaneous drainage used to flush the infected necrotic parts .
[ { "head": { "name": "necrotizing pancreatitis", "pos": [], "type": "" }, "tail": { "name": "L - asparaginase", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Enalaprilat induced acute parotitis .
[ { "head": { "name": "acute parotitis", "pos": [], "type": "" }, "tail": { "name": "Enalaprilat", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The second patient experienced mild nitritoid symptoms following several GSTM injections prior experiencing a cerebrovascular accident within several hours of her next injection .
[ { "head": { "name": "mild nitritoid symptoms", "pos": [], "type": "" }, "tail": { "name": "GSTM", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
After gastric - outlet obstruction was recognized in several infants who received prostaglandin E1 , we studied the association between the drug and this complication .
[ { "head": { "name": "gastric - outlet obstruction", "pos": [], "type": "" }, "tail": { "name": "prostaglandin E1", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Coadministration of antidepressant agents such as nefazodone , or any other drug that inhibits the CYP3A4 isoenzyme subfamily , should be anticipated to interfere with tacrolimus metabolism .
[ { "head": { "name": "interfere with tacrolimus metabolism", "pos": [], "type": "" }, "tail": { "name": "nefazodone", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "interfere with tacrolimus metabolism", "pos": [], "type": "" }, "tail": { "name": "tacrolimus", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report a case of NEH masquerading as cutaneous vasculitis in a woman receiving cyclophosphamide for lupus nephritis .
[ { "head": { "name": "NEH", "pos": [], "type": "" }, "tail": { "name": "cyclophosphamide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Linezolid - associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms ( DRESS ) syndrome .
[ { "head": { "name": "acute interstitial nephritis", "pos": [], "type": "" }, "tail": { "name": "Linezolid", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "DRESS", "pos": [], "type": "" }, "tail": { "name": "Linezolid", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "drug rash with eosinophilia and systemic symptoms", "pos": [], "type": "" }, "tail": { "name": "Linezolid", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We present the case of an adult Crohn 's disease patient with a parvovirus B19 infection and leukopenia during long - term AZA therapy .
[ { "head": { "name": "leukopenia", "pos": [], "type": "" }, "tail": { "name": "AZA", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The present report describes the first case of acute pancreatitis associated with danazol treatment of endometriosis .
[ { "head": { "name": "acute pancreatitis", "pos": [], "type": "" }, "tail": { "name": "danazol", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
In all the patients , pellagra symptoms appeared during isoniazid therapy .
[ { "head": { "name": "pellagra", "pos": [], "type": "" }, "tail": { "name": "isoniazid", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Sweet 's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim , a drug that causes increased neutrophil proliferation and differentiation .
[ { "head": { "name": "acute febrile neutrophilic dermatosis", "pos": [], "type": "" }, "tail": { "name": "filgrastim", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "Sweet 's syndrome", "pos": [], "type": "" }, "tail": { "name": "filgrastim", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The first patient is undergoing hemodialysis and , though responding to sunitinib , is having significant fatigue and hypertension .
[ { "head": { "name": "fatigue", "pos": [], "type": "" }, "tail": { "name": "sunitinib", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hypertension", "pos": [], "type": "" }, "tail": { "name": "sunitinib", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The authors think that although lamivudine is widely used and well tolerated , it can cause ADRs , which are reversible after drug withdrawal .
[ { "head": { "name": "ADRs", "pos": [], "type": "" }, "tail": { "name": "lamivudine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A combination of behavioural and cognitive adverse effects is illustrated in this case report of a recurrent triazolam - induced eating disorder .
[ { "head": { "name": "eating disorder", "pos": [], "type": "" }, "tail": { "name": "triazolam", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Flecainide overdose can rapidly result in profound cardiovascular collapse , and is associated with a relatively high mortality .
[ { "head": { "name": "cardiovascular collapse", "pos": [], "type": "" }, "tail": { "name": "Flecainide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
METHOD : We describe two patients who presented with diabetic ketoacidosis after treatment with quetiapine and risperidone , respectively .
[ { "head": { "name": "diabetic ketoacidosis", "pos": [], "type": "" }, "tail": { "name": "quetiapine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "diabetic ketoacidosis", "pos": [], "type": "" }, "tail": { "name": "risperidone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Two patients with osteomyelitis who developed reversible cholestatic jaundice during treatment with oxacillin derivatives are described .
[ { "head": { "name": "reversible cholestatic jaundice", "pos": [], "type": "" }, "tail": { "name": "oxacillin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
This therapy was also complicated by Warfarin - induced skin necrosis .
[ { "head": { "name": "skin necrosis", "pos": [], "type": "" }, "tail": { "name": "Warfarin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A 77-year - old woman with no history of epilepsy presented a probable nonconvulsive status epilepticus while receiving continuous intravenous morphine for back pain relating to vertebral metastasis of a malignant lymphoma .
[ { "head": { "name": "nonconvulsive status epilepticus", "pos": [], "type": "" }, "tail": { "name": "morphine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Two patients with bipolar affective disorder and a history of bronchospastic phenomena experienced tremor during lithium carbonate therapy .
[ { "head": { "name": "tremor", "pos": [], "type": "" }, "tail": { "name": "lithium carbonate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
CONCLUSIONS : Intrathecal baclofen can impair sexual function and ejaculation in some patients .
[ { "head": { "name": "impair sexual function", "pos": [], "type": "" }, "tail": { "name": "baclofen", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Fatal digoxin poisoning : an unsuccessful resuscitation with use of digoxin - immune Fab .
[ { "head": { "name": "Fatal digoxin poisoning", "pos": [], "type": "" }, "tail": { "name": "digoxin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
An episode of leukoencephalopathy is reported in a 13-year - old girl who , after standard radiotherapy for a posterior fossa medulloblastoma , received 8 treatments with a protocol containing a 4-hour infusion of 500 mg / m2 methotrexate and 12 mg intrathecal methotrexate .
[ { "head": { "name": "leukoencephalopathy", "pos": [], "type": "" }, "tail": { "name": "methotrexate", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "leukoencephalopathy", "pos": [], "type": "" }, "tail": { "name": "methotrexate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The association with prolonged unopposed estrogen - like stimulation with tamoxifen as a possible factor in the development of ovarian endometrioid carcinoma is discussed .
[ { "head": { "name": "ovarian endometrioid carcinoma", "pos": [], "type": "" }, "tail": { "name": "tamoxifen", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
INTRODUCTION - The aim of this case report is to present a 15-year follow - up of a patient with phenytoin ( PHT ) intoxication with unilateral gingival hyperplasia ( GH ) .
[ { "head": { "name": "unilateral gingival hyperplasia", "pos": [], "type": "" }, "tail": { "name": "phenytoin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "unilateral gingival hyperplasia", "pos": [], "type": "" }, "tail": { "name": "PHT", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We experienced 2 cases of mequitazine - induced photosensitivity reaction in patients who took mequitazine for their dermatologic problems .
[ { "head": { "name": "photosensitivity reaction", "pos": [], "type": "" }, "tail": { "name": "mequitazine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "photosensitivity reaction", "pos": [], "type": "" }, "tail": { "name": "mequitazine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Torsade de pointes associated with moxifloxacin : a rare but potentially fatal adverse event .
[ { "head": { "name": "Torsade de pointes", "pos": [], "type": "" }, "tail": { "name": "moxifloxacin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The cases of two asthmatic patients who became hypokalemic after inhalation of normal doses of albuterol are presented .
[ { "head": { "name": "hypokalemic", "pos": [], "type": "" }, "tail": { "name": "albuterol", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis .
[ { "head": { "name": "hepatic adenomas", "pos": [], "type": "" }, "tail": { "name": "danazol", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
In this paper , we report a patient with primary anti - phospholipid syndrome treated by corticosteroid , who developed disseminated nocardiosis .
[ { "head": { "name": "disseminated nocardiosis", "pos": [], "type": "" }, "tail": { "name": "corticosteroid", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A case of clozapine - induced tonic - clonic seizures managed with valproate : implications for clinical care .
[ { "head": { "name": "tonic - clonic seizures", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The epivodes of NMS occured under treatment with clozapine , risperidone , and amisulpride .
[ { "head": { "name": "NMS", "pos": [], "type": "" }, "tail": { "name": "amisulpride", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "NMS", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "NMS", "pos": [], "type": "" }, "tail": { "name": "risperidone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Serotonin syndrome caused by selective serotonin reuptake - inhibitors - metoclopramide interaction .
[ { "head": { "name": "Serotonin syndrome", "pos": [], "type": "" }, "tail": { "name": "metoclopramide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
RESULTS : At our institution , no children appeared with acute INH neurotoxicity in the period 1985 through 1990 , whereas seven patients were treated from 1991 through 1993 .
[ { "head": { "name": "neurotoxicity", "pos": [], "type": "" }, "tail": { "name": "INH", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Hypersensitivity reactions due to chloramphenicol are rarely reported in the literature .
[ { "head": { "name": "Hypersensitivity reactions", "pos": [], "type": "" }, "tail": { "name": "chloramphenicol", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Phenytoin - induced hypersensitivity reactions .
[ { "head": { "name": "hypersensitivity reactions", "pos": [], "type": "" }, "tail": { "name": "Phenytoin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient : growth deficiency , developmental delay , craniosynostosis , blepharophimosis , flat nasal bridge , abnormal ears , and distal limb defects including hypoplastic thumbs and oligodactyly .
[ { "head": { "name": "blepharophimosis", "pos": [], "type": "" }, "tail": { "name": "cyclosposphamide", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "craniosynostosis", "pos": [], "type": "" }, "tail": { "name": "cyclosposphamide", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "developmental delay", "pos": [], "type": "" }, "tail": { "name": "cyclosposphamide", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "distal limb defects", "pos": [], "type": "" }, "tail": { "name": "cyclosposphamide", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "flat nasal bridge", "pos": [], "type": "" }, "tail": { "name": "cyclosposphamide", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hypoplastic thumbs", "pos": [], "type": "" }, "tail": { "name": "cyclosposphamide", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "oligodactyly", "pos": [], "type": "" }, "tail": { "name": "cyclosposphamide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Nitrendipine is an experimental calcium channel blocking agent that also appears to cause the side effect of drug - induced gingival hyperplasia .
[ { "head": { "name": "gingival hyperplasia", "pos": [], "type": "" }, "tail": { "name": "Nitrendipine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report two patients with acne vulgaris with a fourth type of minocycline - induced cutaneous pigmentation .
[ { "head": { "name": "cutaneous pigmentation", "pos": [], "type": "" }, "tail": { "name": "minocycline", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
DISCUSSION : Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure Several drugs have been associated with rhabdomyolysis , including lovastatin , a hydroxymethylglutaryl - coenzyme A reductase inhibitor .
[ { "head": { "name": "rhabdomyolysis", "pos": [], "type": "" }, "tail": { "name": "lovastatin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Rapid resolution of topiramate - induced angle - closure glaucoma with methylprednisolone and mannitol .
[ { "head": { "name": "angle - closure glaucoma", "pos": [], "type": "" }, "tail": { "name": "mannitol", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "angle - closure glaucoma", "pos": [], "type": "" }, "tail": { "name": "methylprednisolone", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "angle - closure glaucoma", "pos": [], "type": "" }, "tail": { "name": "topiramate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
This is the first report of UFT - induced scleroderma - like reaction .
[ { "head": { "name": "UFT - induced scleroderma - like reaction", "pos": [], "type": "" }, "tail": { "name": "UFT", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Disseminated cellulitic cryptococcosis in the setting of prednisone monotherapy for pemphigus vulgaris .
[ { "head": { "name": "Disseminated cellulitic cryptococcosis", "pos": [], "type": "" }, "tail": { "name": "prednisone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A patient receiving vancomycin for a serious staphylococcal infection had a lupus - like syndrome characterized by a malar rash , pain and erythema of the cartilage of both ears , and tender erythematous and hemorrhagic lesions of the finger tips .
[ { "head": { "name": "erythema of the cartilage of both ears", "pos": [], "type": "" }, "tail": { "name": "vancomycin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hemorrhagic lesions of the finger tips", "pos": [], "type": "" }, "tail": { "name": "vancomycin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "lupus - like syndrome", "pos": [], "type": "" }, "tail": { "name": "vancomycin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "malar rash", "pos": [], "type": "" }, "tail": { "name": "vancomycin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "pain", "pos": [], "type": "" }, "tail": { "name": "vancomycin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "tender erythematous", "pos": [], "type": "" }, "tail": { "name": "vancomycin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Antithyroid treatment with propylthiouracil ( PTU ) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole ( CBZ ) .
[ { "head": { "name": "elevated hepatic enzymes", "pos": [], "type": "" }, "tail": { "name": "propylthiouracil", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "elevated hepatic enzymes", "pos": [], "type": "" }, "tail": { "name": "PTU", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
OBJECTIVE : To report a case of severe chloroquine toxicity in the presence of high - grade chloroquine - resistant Plasmodium vivax .
[ { "head": { "name": "severe chloroquine toxicity", "pos": [], "type": "" }, "tail": { "name": "chloroquine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Clinicians should be vigilant when monitoring for cardiotoxicity in patients receiving pentamidine throughout the duration of therapy .
[ { "head": { "name": "cardiotoxicity", "pos": [], "type": "" }, "tail": { "name": "pentamidine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid - induced coma .
[ { "head": { "name": "coma", "pos": [], "type": "" }, "tail": { "name": "valproic acid", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Gold - induced pneumonitis .
[ { "head": { "name": "pneumonitis", "pos": [], "type": "" }, "tail": { "name": "Gold", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We describe a 5-year - old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment .
[ { "head": { "name": "cranial polyneuropathy", "pos": [], "type": "" }, "tail": { "name": "vincristine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
On the fifth day after administration of a high dose of ARA - C ( 2 g / m2 intravenously every 12 hours ) , she developed bullous lesions on the hands and soles that disseminated , evolving to necrosis , sepsis , and death on the 22nd day .
[ { "head": { "name": "bullous lesions on the hands and soles that disseminated , evolving to necrosis", "pos": [], "type": "" }, "tail": { "name": "ARA - C", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "death", "pos": [], "type": "" }, "tail": { "name": "ARA - C", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "sepsis", "pos": [], "type": "" }, "tail": { "name": "ARA - C", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Acute interstitial pneumonia induced by ONO-1078 ( pranlukast ) , a leukotriene receptor antagonist .
[ { "head": { "name": "interstitial pneumonia", "pos": [], "type": "" }, "tail": { "name": "ONO-1078", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "interstitial pneumonia", "pos": [], "type": "" }, "tail": { "name": "pranlukast", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Pellagra encephalopathy among tuberculous patients : its relation to isoniazid therapy .
[ { "head": { "name": "Pellagra encephalopathy", "pos": [], "type": "" }, "tail": { "name": "isoniazid", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Among 12 thyrotoxic patients , a patient with arrhythmogenic right ventricular dysplasia , who had been taking amiodarone for 4 years , developed thyrotoxicosis with subacute onset , accompanied by transiently positive thyrotropin ( TSH ) receptor antibody ( TRAb ) , or thyrotropin - binding inhibiting immunoglobulin ( TBII ) .
[ { "head": { "name": "thyrotoxicosis", "pos": [], "type": "" }, "tail": { "name": "amiodarone", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "thyrotropin - binding inhibiting immunoglobulin", "pos": [], "type": "" }, "tail": { "name": "amiodarone", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "transiently positive thyrotropin ( TSH ) receptor antibody", "pos": [], "type": "" }, "tail": { "name": "amiodarone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
To our knowledge , this is the first reported case of bromide intoxication due to pyridostigmine bromide administration .
[ { "head": { "name": "bromide intoxication", "pos": [], "type": "" }, "tail": { "name": "pyridostigmine bromide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
In a patient with severe renovascular hypertension , nonoliguric acute renal failure developed after she received captopril treatment .
[ { "head": { "name": "nonoliguric acute renal failure", "pos": [], "type": "" }, "tail": { "name": "captopril", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report a patient in whom the anti - depressant trazodone hydrochloride ( Molipaxin , Roussel ) , a serotonin antagonist , provoked generalized pustular psoriasis ( GPP ) .
[ { "head": { "name": "generalized pustular psoriasis", "pos": [], "type": "" }, "tail": { "name": "Molipaxin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "generalized pustular psoriasis", "pos": [], "type": "" }, "tail": { "name": "trazodone hydrochloride", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "GPP", "pos": [], "type": "" }, "tail": { "name": "Molipaxin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "GPP", "pos": [], "type": "" }, "tail": { "name": "trazodone hydrochloride", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Corneal endothelial dysfunction associated with amantadine toxicity .
[ { "head": { "name": "Corneal endothelial dysfunction", "pos": [], "type": "" }, "tail": { "name": "amantadine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A patient with chronic myelomonocytic leukemia developed drug - induced pulmonary toxicity after using low dose oral etoposide .
[ { "head": { "name": "pulmonary toxicity", "pos": [], "type": "" }, "tail": { "name": "etoposide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Fluorouracil for allergic reactions to capecitabine .
[ { "head": { "name": "allergic reactions", "pos": [], "type": "" }, "tail": { "name": "capecitabine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
In this case , interferon alpha induced polymyositis and cardiomyopathy is diagnosed in a 33-yr - old male patient with history of chronic hepatitis B .
[ { "head": { "name": "cardiomyopathy", "pos": [], "type": "" }, "tail": { "name": "interferon alpha", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "polymyositis", "pos": [], "type": "" }, "tail": { "name": "interferon alpha", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Methamphetamine 's extensive physiologic effects , inconsistent street purity , and multiple routes of administration offer many possibilities for injury to the cornea .
[ { "head": { "name": "injury to the cornea", "pos": [], "type": "" }, "tail": { "name": "Methamphetamine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Multicentric hepatocellular carcinoma following phosphate diethylstilbestrol therapy for prostatic cancer .
[ { "head": { "name": "Multicentric hepatocellular carcinoma", "pos": [], "type": "" }, "tail": { "name": "phosphate diethylstilbestrol", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all - trans retinoic acid .
[ { "head": { "name": "Relapse in the external auditory canal of acute promyelocytic leukemia", "pos": [], "type": "" }, "tail": { "name": "all - trans retinoic acid", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The medical examiner 's report indicated death caused by fluoxetine toxicity .
[ { "head": { "name": "death", "pos": [], "type": "" }, "tail": { "name": "fluoxetine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "fluoxetine toxicity", "pos": [], "type": "" }, "tail": { "name": "fluoxetine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Withdrawal emergent syndrome in an infant associated with maternal haloperidol therapy .
[ { "head": { "name": "Withdrawal emergent syndrome", "pos": [], "type": "" }, "tail": { "name": "haloperidol", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide ( CY ) paired with taste ( cod liver oil ) and smell ( rose perfume ) as conditioned stimuli .
[ { "head": { "name": "severe lupus erythematosus", "pos": [], "type": "" }, "tail": { "name": "CY", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "severe lupus erythematosus", "pos": [], "type": "" }, "tail": { "name": "cyclophosphamide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report a 78-year - old man who had acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia .
[ { "head": { "name": "acute unilateral total visual loss", "pos": [], "type": "" }, "tail": { "name": "phenol", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Cystoid macular edema in a low - risk patient after switching from latanoprost to bimatoprost .
[ { "head": { "name": "Cystoid macular edema", "pos": [], "type": "" }, "tail": { "name": "bimatoprost", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "Cystoid macular edema", "pos": [], "type": "" }, "tail": { "name": "latanoprost", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
INH , which is a leading cause of drug eruptions in the above group of drugs was withdrawn .
[ { "head": { "name": "drug eruptions", "pos": [], "type": "" }, "tail": { "name": "INH", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Gigantomastia induced by bucillamine .
[ { "head": { "name": "Gigantomastia", "pos": [], "type": "" }, "tail": { "name": "bucillamine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
To our knowledge , this is the first case of ivermectin - induced severe liver disease published in the literature .
[ { "head": { "name": "severe liver disease", "pos": [], "type": "" }, "tail": { "name": "ivermectin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus - like syndrome .
[ { "head": { "name": "diabetes insipidus - like syndrome", "pos": [], "type": "" }, "tail": { "name": "Lithium", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "diabetes insipidus - like syndrome", "pos": [], "type": "" }, "tail": { "name": "lithium", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "lithium intoxication", "pos": [], "type": "" }, "tail": { "name": "Lithium", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "lithium intoxication", "pos": [], "type": "" }, "tail": { "name": "lithium", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The authors suggest that risperidone may increase affect in patients with schizophrenia and that some patients , especially those with anxiety , may have difficulty managing the increase .
[ { "head": { "name": "increase affect", "pos": [], "type": "" }, "tail": { "name": "risperidone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A fatal massive pulmonary embolus developed in a patient treated with streptokinase for acute deep vein thrombosis .
[ { "head": { "name": "fatal massive pulmonary embolus", "pos": [], "type": "" }, "tail": { "name": "streptokinase", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The possible development of a drug - induced vasculitis or lupus - like syndrome should be added to the list of rare toxic effects of vancomycin .
[ { "head": { "name": "lupus - like syndrome", "pos": [], "type": "" }, "tail": { "name": "vancomycin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "vasculitis", "pos": [], "type": "" }, "tail": { "name": "vancomycin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Sulfadiazine crystalluria revisited .
[ { "head": { "name": "crystalluria", "pos": [], "type": "" }, "tail": { "name": "Sulfadiazine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
To treat hepatitis B , interferon alpha was administered until the proximal muscle weakness developed .
[ { "head": { "name": "muscle weakness", "pos": [], "type": "" }, "tail": { "name": "interferon alpha", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Tuberculous uveitis after treatment with etanercept .
[ { "head": { "name": "Tuberculous uveitis", "pos": [], "type": "" }, "tail": { "name": "etanercept", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Although it is difficult to solely attribute intratumoral hemorrhage to aspirin , we have to be careful when prescribing aspirin for patients who have asymptomatic meningioma .
[ { "head": { "name": "intratumoral hemorrhage", "pos": [], "type": "" }, "tail": { "name": "aspirin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Leiomyosarcoma in urinary bladder after cyclophosphamide therapy for retinoblastoma and review of bladder sarcomas .
[ { "head": { "name": "Leiomyosarcoma", "pos": [], "type": "" }, "tail": { "name": "cyclophosphamide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Leukaemoid monocytosis in M4 AML following chemotherapy and G - CSF .
[ { "head": { "name": "Leukaemoid monocytosis", "pos": [], "type": "" }, "tail": { "name": "G - CSF", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Transient asymptomatic bradycardia in patients on infusional 5-fluorouracil .
[ { "head": { "name": "Transient asymptomatic bradycardia", "pos": [], "type": "" }, "tail": { "name": "5-fluorouracil", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis .
[ { "head": { "name": "hepatic decompensation", "pos": [], "type": "" }, "tail": { "name": "MTX", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Allergic contact dermatitis to compound tincture of benzoin .
[ { "head": { "name": "Allergic contact dermatitis", "pos": [], "type": "" }, "tail": { "name": "benzoin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]