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We report a patient who developed acute pancreatitis during amiodarone therapy .
[ { "head": { "name": "acute pancreatitis", "pos": [], "type": "" }, "tail": { "name": "amiodarone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Acute pancreatitis after long - term 5-aminosalicylic acid therapy .
[ { "head": { "name": "Acute pancreatitis", "pos": [], "type": "" }, "tail": { "name": "5-aminosalicylic acid", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
These in vitro findings and clinical course suggest that TRAb / TBII without thyroid - stimulating activity may develop in patients with amiodarone - induced destructive thyroiditis , as reported in patients with destructive thyroiditis , such as subacute and silent thyroiditis .
[ { "head": { "name": "destructive thyroiditis", "pos": [], "type": "" }, "tail": { "name": "amiodarone", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "destructive thyroiditis", "pos": [], "type": "" }, "tail": { "name": "amiodarone", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "thyroiditis", "pos": [], "type": "" }, "tail": { "name": "amiodarone", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "TRAb / TBII without thyroid - stimulating activity", "pos": [], "type": "" }, "tail": { "name": "amiodarone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A 10-year - old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high - dose methotrexate ( MTX ) ( 12 g / m2 ) , and went on to develop acute renal failure with life - threatening hyperkalemia 29 hours later .
[ { "head": { "name": "acute renal failure", "pos": [], "type": "" }, "tail": { "name": "methotrexate", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "acute renal failure", "pos": [], "type": "" }, "tail": { "name": "MTX", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "elevation of aspartate aminotrasferase", "pos": [], "type": "" }, "tail": { "name": "methotrexate", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "elevation of aspartate aminotrasferase", "pos": [], "type": "" }, "tail": { "name": "MTX", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "renal toxicity", "pos": [], "type": "" }, "tail": { "name": "methotrexate", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "renal toxicity", "pos": [], "type": "" }, "tail": { "name": "MTX", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Described here are 2 patients who developed thrombotic microangiopathy of the kidneys after receiving high cumulative doses of the new anticancer drug gemcitabine .
[ { "head": { "name": "thrombotic microangiopathy", "pos": [], "type": "" }, "tail": { "name": "gemcitabine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We describe a 41 yr old leprosy patient treated for 10 yrs with clofazimine who underwent laparotomy for severe abdominal pain .
[ { "head": { "name": "abdominal pain", "pos": [], "type": "" }, "tail": { "name": "clofazimine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We have seen a case of terminal malignant melanoma in which clinical manifestations , indicative of anterior spinal artery syndrome , developed following the injection of 0.3 ml of 10 % phenol - glycerine into the cervical subarachnoid space at the C4 - -C5 level for the control of severe right arm pain .
[ { "head": { "name": "anterior spinal artery syndrome", "pos": [], "type": "" }, "tail": { "name": "phenol - glycerine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Temsirolimus - induced glomerulopathy .
[ { "head": { "name": "glomerulopathy", "pos": [], "type": "" }, "tail": { "name": "Temsirolimus", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We describe rupture of a cerebral arterial aneurysm in a 32 year old hypertensive woman following the introduction of nifedipine treatment .
[ { "head": { "name": "rupture of a cerebral arterial aneurysm", "pos": [], "type": "" }, "tail": { "name": "nifedipine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
DLST is a good diagnostic tool for AZA allergy , especially for severe drug allergy cases .
[ { "head": { "name": "allergy", "pos": [], "type": "" }, "tail": { "name": "AZA", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
These novel findings may offer specific therapeutic targets in the treatment of BCNU - associated pulmonary fibrosis .
[ { "head": { "name": "pulmonary fibrosis", "pos": [], "type": "" }, "tail": { "name": "BCNU", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We present a case of stroke after PPA ingestion that occurred 4 months after the recall in an 8-year - old boy on chronic peritoneal dialysis .
[ { "head": { "name": "stroke", "pos": [], "type": "" }, "tail": { "name": "PPA", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report a case of AILD in an 80-year - old male who presented with a generalized pruritic maculopapular eruption and fever following doxycycline administration .
[ { "head": { "name": "AILD", "pos": [], "type": "" }, "tail": { "name": "doxycycline", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "fever", "pos": [], "type": "" }, "tail": { "name": "doxycycline", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "generalized pruritic maculopapular eruption", "pos": [], "type": "" }, "tail": { "name": "doxycycline", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The male patient was treated with 225-mg / day clozapine and the time to the diagnosis of agranulocytosis was 6 weeks .
[ { "head": { "name": "agranulocytosis", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Unintended exposure to acyclovir early in pregnancy , which is not uncommon , may cause excessive maternal and physician anxiety .
[ { "head": { "name": "excessive maternal and physician anxiety", "pos": [], "type": "" }, "tail": { "name": "acyclovir", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Optic neuropathy developed in a patient with rheumatoid arthritis who had been receiving D - penicillamine for about 1 year .
[ { "head": { "name": "Optic neuropathy", "pos": [], "type": "" }, "tail": { "name": "D - penicillamine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A 73 year - old patient with Wolff - Parkinson - White syndrome and paroxysmic supraventricular tachycardia developed an acute reversible encephalopathy within 15 days of initiation of flecainide .
[ { "head": { "name": "acute reversible encephalopathy", "pos": [], "type": "" }, "tail": { "name": "flecainide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication .
[ { "head": { "name": "raised intracranial pressure", "pos": [], "type": "" }, "tail": { "name": "valproic acid", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The patient 's other comorbidities and medications have not been suggested as possible interactions with sertraline that can cause rhabdomyolysis .
[ { "head": { "name": "rhabdomyolysis", "pos": [], "type": "" }, "tail": { "name": "sertraline", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines .
[ { "head": { "name": "Osteonecrosis", "pos": [], "type": "" }, "tail": { "name": "dexamethasone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A drug interaction between zafirlukast and theophylline .
[ { "head": { "name": "drug interaction", "pos": [], "type": "" }, "tail": { "name": "theophylline", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "drug interaction", "pos": [], "type": "" }, "tail": { "name": "zafirlukast", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Sulfasalazine - induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy , despite the absence of pulmonary symptomatology .
[ { "head": { "name": "lung disorder", "pos": [], "type": "" }, "tail": { "name": "Sulfasalazine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "ulcerative colitis", "pos": [], "type": "" }, "tail": { "name": "Sulfasalazine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "ulcerative colitis", "pos": [], "type": "" }, "tail": { "name": "sulfasalazine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
In this report , we present a case of hypoglycaemic coma associated with SP , an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases .
[ { "head": { "name": "hypoglycaemic coma", "pos": [], "type": "" }, "tail": { "name": "SP", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hypoglycaemic coma", "pos": [], "type": "" }, "tail": { "name": "SP", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A 66-year - old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin - specific antibody fragments .
[ { "head": { "name": "complete atrioventricular block", "pos": [], "type": "" }, "tail": { "name": "digoxin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A 15-year follow - up of phenytoin - induced unilateral gingival hyperplasia : a case report .
[ { "head": { "name": "unilateral gingival hyperplasia", "pos": [], "type": "" }, "tail": { "name": "phenytoin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report a case of successful surgical management of arterial thrombosis after percutaneous thrombin injection of a femoral artery pseudoaneurysm in a 69-year - old woman .
[ { "head": { "name": "arterial thrombosis", "pos": [], "type": "" }, "tail": { "name": "thrombin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open - angle glaucoma .
[ { "head": { "name": "choroidal detachment", "pos": [], "type": "" }, "tail": { "name": "dorzolamide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report on three cases wherein treatment of dexmedetomidine - induced bradycardia with i.v . glycopyrrolate ( 5.0 microg / kg ) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure .
[ { "head": { "name": "bradycardia", "pos": [], "type": "" }, "tail": { "name": "dexmedetomidine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "exaggerated increase of arterial blood pressure", "pos": [], "type": "" }, "tail": { "name": "glycopyrrolate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Trimethoprim - sulfamethoxazole - induced hepatotoxicity in a pediatric patient .
[ { "head": { "name": "hepatotoxicity", "pos": [], "type": "" }, "tail": { "name": "Trimethoprim - sulfamethoxazole", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
He had hypokalemia ( K 2.3 mmol / L ) induced by licorice and also had received disopyramide for arrhythmia , bicalutamide for prostate cancer , and silodosin for prostate hypertrophy .
[ { "head": { "name": "hypokalemia", "pos": [], "type": "" }, "tail": { "name": "licorice", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Early peritoneal dialysis has not previously been reported for lisinopril induced multiorgan failure .
[ { "head": { "name": "multiorgan failure", "pos": [], "type": "" }, "tail": { "name": "lisinopril", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
This case report describes a patient who was previously prescribed alendronate ( Fosamax ) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho - Soda .
[ { "head": { "name": "hypocalcemic tetany", "pos": [], "type": "" }, "tail": { "name": "alendronate", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hypocalcemic tetany", "pos": [], "type": "" }, "tail": { "name": "Fleet Phospho - Soda", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hypocalcemic tetany", "pos": [], "type": "" }, "tail": { "name": "Fosamax", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hypophosphatemia", "pos": [], "type": "" }, "tail": { "name": "alendronate", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hypophosphatemia", "pos": [], "type": "" }, "tail": { "name": "Fleet Phospho - Soda", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hypophosphatemia", "pos": [], "type": "" }, "tail": { "name": "Fosamax", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A brief review of reported cases of chloramphenicol hypersensitivity in the English - language literature , as well as possible alternative explanations in this case , are provided .
[ { "head": { "name": "hypersensitivity", "pos": [], "type": "" }, "tail": { "name": "chloramphenicol", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Refractory hypoglycemia from ciprofloxacin and glyburide interaction .
[ { "head": { "name": "Refractory hypoglycemia", "pos": [], "type": "" }, "tail": { "name": "ciprofloxacin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "Refractory hypoglycemia", "pos": [], "type": "" }, "tail": { "name": "glyburide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Rupture of a cerebral aneurysm associated with nifedipine treatment .
[ { "head": { "name": "Rupture of a cerebral aneurysm", "pos": [], "type": "" }, "tail": { "name": "nifedipine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
An unusual case of Ecstasy poisoning .
[ { "head": { "name": "Ecstasy poisoning", "pos": [], "type": "" }, "tail": { "name": "Ecstasy", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
It is presumed that her hyperchloremic metabolic acidosis was secondary to cholestyramine because of the similarity to pediatric reports ; the rapid and lasting response to intravenous sodium bicarbonate ; the absence of another etiology ; normal serum potassium , chloride and bicarbonate despite continued spironolactone therapy after recovery .
[ { "head": { "name": "hyperchloremic metabolic acidosis", "pos": [], "type": "" }, "tail": { "name": "cholestyramine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A patient developed optic neuropathy while being treated with isoniazid and ethambutol .
[ { "head": { "name": "optic neuropathy", "pos": [], "type": "" }, "tail": { "name": "ethambutol", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "optic neuropathy", "pos": [], "type": "" }, "tail": { "name": "isoniazid", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
CONCLUSIONS : The piloerection observed after the replacement of fluvoxamine with milnacipran in this patient appears to have been due to an increase in the alpha(1 ) - adrenoceptor occupancy by endogenous norepinephrine induced by milnacipran .
[ { "head": { "name": "piloerection", "pos": [], "type": "" }, "tail": { "name": "fluvoxamine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "piloerection", "pos": [], "type": "" }, "tail": { "name": "milnacipran", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Four years after the beginning of IFN therapy , he acutely developed moderate hyperglycemia and severe ketonuria with positive islet cell antibody , and then 28 units / day of insulin injection was started .
[ { "head": { "name": "moderate hyperglycemia", "pos": [], "type": "" }, "tail": { "name": "IFN", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "severe ketonuria", "pos": [], "type": "" }, "tail": { "name": "IFN", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A 65-year - old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression .
[ { "head": { "name": "movement disorder", "pos": [], "type": "" }, "tail": { "name": "lithium", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "movement disorder", "pos": [], "type": "" }, "tail": { "name": "trazodone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
OBJECTIVE : We report a patient who developed neutropenia on clozapine , but behind the cell count decrease showed to be a diurnal variation of the white blood cells ( WBC ) .
[ { "head": { "name": "diurnal variation of the white blood cells", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Therefore , we diagnosed her eruption as contact dermatitis due to sodium bisulfite .
[ { "head": { "name": "contact dermatitis", "pos": [], "type": "" }, "tail": { "name": "sodium bisulfite", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "eruption", "pos": [], "type": "" }, "tail": { "name": "sodium bisulfite", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
After the chlorambucil was discontinued , the wbc count began to slowly rise and the patient developed clinical AML .
[ { "head": { "name": "AML", "pos": [], "type": "" }, "tail": { "name": "chlorambucil", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Disopyramide - induced heart block .
[ { "head": { "name": "heart block", "pos": [], "type": "" }, "tail": { "name": "Disopyramide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
CASE SUMMARY : A 57-year - old female with cardiomyopathy and " sulfa " ( trimethoprim / sulfamethoxazole ) allergy documented as pancreatitis presented with symptoms consistent with pancreatitis after use of furosemide .
[ { "head": { "name": "pancreatitis", "pos": [], "type": "" }, "tail": { "name": "furosemide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
To our knowledge , the syndrome of fever , pulmonary infiltrates , and pleural effusion following use of acyclovir has not been previously reported .
[ { "head": { "name": "fever", "pos": [], "type": "" }, "tail": { "name": "acyclovir", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "pleural effusion", "pos": [], "type": "" }, "tail": { "name": "acyclovir", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "pulmonary infiltrates", "pos": [], "type": "" }, "tail": { "name": "acyclovir", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Albuterol - induced hypokalemia and its potential cardiac toxicity are discussed briefly .
[ { "head": { "name": "cardiac toxicity", "pos": [], "type": "" }, "tail": { "name": "Albuterol", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hypokalemia", "pos": [], "type": "" }, "tail": { "name": "Albuterol", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Severe hepatotoxicity related to benzarone : a report of three cases with two fatalities .
[ { "head": { "name": "Severe hepatotoxicity", "pos": [], "type": "" }, "tail": { "name": "benzarone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship ( score of 5 ) between the patient 's development of hepatotoxicity and the TMP - SMX therapy .
[ { "head": { "name": "hepatotoxicity", "pos": [], "type": "" }, "tail": { "name": "TMP - SMX", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
CASE SUMMARIES : Two patients with stable hypothyroidism experienced symptoms of hypothyroidism with increased serum thyroid - stimulating hormone ( TSH ) concentrations after switching from 1 levothyroxine product to another .
[ { "head": { "name": "increased serum thyroid - stimulating hormone", "pos": [], "type": "" }, "tail": { "name": "levothyroxine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Case 4 : A 61-year - old male alcoholic who remained completely abstinent while taking cyanamide for 3 years showed slight elevation of serum transaminases .
[ { "head": { "name": "elevation of serum transaminases", "pos": [], "type": "" }, "tail": { "name": "cyanamide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen .
[ { "head": { "name": "morbidity", "pos": [], "type": "" }, "tail": { "name": "hyperbaric oxygen", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Stupor and fast activity on electroencephalography in a child treated with valproate .
[ { "head": { "name": "Stupor", "pos": [], "type": "" }, "tail": { "name": "valproate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The events of non - convulsive status epilepticus subsided following reduction in tiagabine dosages .
[ { "head": { "name": "non - convulsive status epilepticus", "pos": [], "type": "" }, "tail": { "name": "tiagabine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
This entity is probably related to a combination of high doses of corticosteroids , vecuronium administration and metabolic abnormalities associated with respiratory failure .
[ { "head": { "name": "respiratory failure", "pos": [], "type": "" }, "tail": { "name": "vecuronium", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Upper tract urothelial malignancy after cyclophosphamide therapy : a case report and literature review .
[ { "head": { "name": "Upper tract urothelial malignancy", "pos": [], "type": "" }, "tail": { "name": "cyclophosphamide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Rhabdomyolysis associated with the use of intravenous vasopressin .
[ { "head": { "name": "Rhabdomyolysis", "pos": [], "type": "" }, "tail": { "name": "vasopressin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We describe a case of an NHL patient who received rituximab and developed symptomatic , biopsy - proven multinodular bronchiolitis obliterans with organizing pneumonia ( BOOP ) .
[ { "head": { "name": "bronchiolitis obliterans with organizing pneumonia", "pos": [], "type": "" }, "tail": { "name": "rituximab", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
RESULTS : Both patients experienced a previously unreported side effect -- falling backward -- associated with bupropion use .
[ { "head": { "name": "falling backward", "pos": [], "type": "" }, "tail": { "name": "bupropion", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
OBJECTIVE : To report a case of linear immunoglobulin ( Ig ) A bullous dermatosis ( LABD ) induced by gemcitabine .
[ { "head": { "name": "LABD", "pos": [], "type": "" }, "tail": { "name": "gemcitabine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "linear immunoglobulin ( Ig ) A bullous dermatosis", "pos": [], "type": "" }, "tail": { "name": "gemcitabine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
To the best of our knowledge , this is the first reported patient with captopril - induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril .
[ { "head": { "name": "pemphigus", "pos": [], "type": "" }, "tail": { "name": "captopril", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We present findings from three patients who experienced a psoriasiform eruption apparently due to the antiepileptic agents sodium valproate and carbamazepine .
[ { "head": { "name": "psoriasiform eruption", "pos": [], "type": "" }, "tail": { "name": "carbamazepine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "psoriasiform eruption", "pos": [], "type": "" }, "tail": { "name": "sodium valproate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
In our patient , DIAN possibly was related to cefuroxime , but the patient did not experience associated allergic symptoms .
[ { "head": { "name": "DIAN", "pos": [], "type": "" }, "tail": { "name": "cefuroxime", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Thus , the patient 's clinical course and workup strongly support a diagnosis of lenalidomide - induced hypersensitivity pneumonitis - like syndrome .
[ { "head": { "name": "hypersensitivity pneumonitis - like syndrome", "pos": [], "type": "" }, "tail": { "name": "lenalidomide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Within 3 weeks of beginning continuous daily isoniazid and rifampin therapy for pulmonary tuberculosis , a patient developed acute renal failure .
[ { "head": { "name": "acute renal failure", "pos": [], "type": "" }, "tail": { "name": "isoniazid", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "acute renal failure", "pos": [], "type": "" }, "tail": { "name": "rifampin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
CONCLUSIONS : These results suggest that clozapine may cause TD ; however , the prevalence is low and the severity is relatively mild , with no or mild self - reported discomfort .
[ { "head": { "name": "discomfort", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "TD", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide .
[ { "head": { "name": "panhypogammaglobulinaemia", "pos": [], "type": "" }, "tail": { "name": "cyclophosphamide", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "panhypogammaglobulinaemia", "pos": [], "type": "" }, "tail": { "name": "prednisolone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Central nervous system manifestations of an ibuprofen overdose reversed by naloxone .
[ { "head": { "name": "Central nervous system manifestations", "pos": [], "type": "" }, "tail": { "name": "ibuprofen", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Generalised pustular psoriasis induced by cyclosporin a withdrawal responding to the tumour necrosis factor alpha inhibitor etanercept .
[ { "head": { "name": "Generalised pustular psoriasis", "pos": [], "type": "" }, "tail": { "name": "cyclosporin a", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We describe children and adolescents with chronic hematologic and oncologic diseases who exhibited drug - seeking behavior or anticholinergic symptoms with the use of diphenhydramine .
[ { "head": { "name": "anticholinergic symptoms", "pos": [], "type": "" }, "tail": { "name": "diphenhydramine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "drug - seeking behavior", "pos": [], "type": "" }, "tail": { "name": "diphenhydramine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Myoclonus was induced and enhanced by L - dopa , developing into generalized seizures .
[ { "head": { "name": "generalized seizures", "pos": [], "type": "" }, "tail": { "name": "L - dopa", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "Myoclonus", "pos": [], "type": "" }, "tail": { "name": "L - dopa", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Patients from endemic areas referred to transplant centers may be at high risk for disseminated histoplasmosis when treated with long - term prednisone for graft - versus - host disease .
[ { "head": { "name": "disseminated histoplasmosis", "pos": [], "type": "" }, "tail": { "name": "prednisone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A 62-year - old Indian with diabetic nephropathy controlled with metformin , developed miliary tuberculosis for which he was treated with rifampicin , isoniazid and ethambutol .
[ { "head": { "name": "miliary tuberculosis", "pos": [], "type": "" }, "tail": { "name": "metformin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A diagnosis of infliximab - induced lupus was made and the drug treatment was withdrawn .
[ { "head": { "name": "lupus", "pos": [], "type": "" }, "tail": { "name": "infliximab", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report the case of a man , treated with mesalazine for Crohn 's disease who developed drug - induced pericarditis .
[ { "head": { "name": "pericarditis", "pos": [], "type": "" }, "tail": { "name": "mesalazine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The possible effects of tamoxifen upon the uterus are discussed in this article , in view of reports of tamoxifen associated with endometrial carcinoma and endometriosis .
[ { "head": { "name": "endometrial carcinoma", "pos": [], "type": "" }, "tail": { "name": "tamoxifen", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "endometriosis", "pos": [], "type": "" }, "tail": { "name": "tamoxifen", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Jaundice induced by streptokinase .
[ { "head": { "name": "Jaundice", "pos": [], "type": "" }, "tail": { "name": "streptokinase", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I , but based on clinical , pathological and microanalytical differences , appears to be a new entity .
[ { "head": { "name": "hyperpigmentation", "pos": [], "type": "" }, "tail": { "name": "minocycline", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We describe a patient with the antiphospholipid syndrome who had skin necrosis develop from low - molecular weight heparin therapy at sites distant from injection sites .
[ { "head": { "name": "skin necrosis", "pos": [], "type": "" }, "tail": { "name": "low - molecular weight heparin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
OBJECTIVE : To report a case of colchicine - induced myopathy in a teenager with familial Mediterranean fever ( FMF ) .
[ { "head": { "name": "myopathy", "pos": [], "type": "" }, "tail": { "name": "colchicine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Azathioprine - induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis .
[ { "head": { "name": "myelosuppression", "pos": [], "type": "" }, "tail": { "name": "Azathioprine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
CONCLUSIONS : Cefazolin was a probable cause of this patient 's leukopenia .
[ { "head": { "name": "leukopenia", "pos": [], "type": "" }, "tail": { "name": "Cefazolin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Persisent ocular hypertension following intravitreal ranibizumab .
[ { "head": { "name": "Persisent ocular hypertension", "pos": [], "type": "" }, "tail": { "name": "ranibizumab", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Serious phenytoin hypersensitivity reactions may appear as dermatologic , lymphoid , or hepatic syndromes .
[ { "head": { "name": "dermatologic , lymphoid , or hepatic syndromes", "pos": [], "type": "" }, "tail": { "name": "phenytoin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hypersensitivity reactions", "pos": [], "type": "" }, "tail": { "name": "phenytoin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Four Chinese female patients who suffered from manic - depressive disorder and underlying autoimmune thyroiditis developed transient episodes of thyrotoxicosis during maintenance lithium therapy .
[ { "head": { "name": "thyrotoxicosis", "pos": [], "type": "" }, "tail": { "name": "lithium", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
One of the side - effects of intravitreal triamcinolone is the development of cataract , and it is known that cataract extraction can exacerbate macular degeneration .
[ { "head": { "name": "cataract", "pos": [], "type": "" }, "tail": { "name": "triamcinolone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Although myelosuppression is mild , immunosuppression and superinfection are potential hazards of treatment with DCF .
[ { "head": { "name": "immunosuppression", "pos": [], "type": "" }, "tail": { "name": "DCF", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "superinfection", "pos": [], "type": "" }, "tail": { "name": "DCF", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A 17-year - old female patient who had been taking oral minocycline ( 50 mg twice daily ) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis .
[ { "head": { "name": "eruption", "pos": [], "type": "" }, "tail": { "name": "minocycline", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "exfoliative dermatitis", "pos": [], "type": "" }, "tail": { "name": "minocycline", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Children receiving zonisamide should be monitored for oligohidrosis and the development of neurological symptoms associated with an elevation of body temperature .
[ { "head": { "name": "neurological symptoms", "pos": [], "type": "" }, "tail": { "name": "zonisamide", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "oligohidrosis", "pos": [], "type": "" }, "tail": { "name": "zonisamide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report a rare case of colonic mucosal necrosis following Kalimate ( calcium polystryrene sulfonate ) , an analogue of Kayexalate without sorbitol in a 34-yr - old man .
[ { "head": { "name": "colonic mucosal necrosis", "pos": [], "type": "" }, "tail": { "name": "calcium polystryrene sulfonate", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "colonic mucosal necrosis", "pos": [], "type": "" }, "tail": { "name": "Kalimate", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "colonic mucosal necrosis", "pos": [], "type": "" }, "tail": { "name": "Kayexalate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
RESULTS : Budesonide use can cause contact dermatitis .
[ { "head": { "name": "contact dermatitis", "pos": [], "type": "" }, "tail": { "name": "Budesonide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
He had been taking trimethoprim - sulfamethoxazole for approximately eight days when he revisited his family physician , complaining of headaches , dizziness , difficulty with speech , weakness , and itching on the trunk of his body and legs , where a maculopapular rash was noted .
[ { "head": { "name": "difficulty with speech", "pos": [], "type": "" }, "tail": { "name": "sulfamethoxazole", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "difficulty with speech", "pos": [], "type": "" }, "tail": { "name": "trimethoprim", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "dizziness", "pos": [], "type": "" }, "tail": { "name": "sulfamethoxazole", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "dizziness", "pos": [], "type": "" }, "tail": { "name": "trimethoprim", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "headaches", "pos": [], "type": "" }, "tail": { "name": "sulfamethoxazole", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "headaches", "pos": [], "type": "" }, "tail": { "name": "trimethoprim", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "itching on the trunk", "pos": [], "type": "" }, "tail": { "name": "sulfamethoxazole", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "itching on the trunk", "pos": [], "type": "" }, "tail": { "name": "trimethoprim", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "maculopapular rash", "pos": [], "type": "" }, "tail": { "name": "sulfamethoxazole", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "maculopapular rash", "pos": [], "type": "" }, "tail": { "name": "trimethoprim", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "weakness", "pos": [], "type": "" }, "tail": { "name": "sulfamethoxazole", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "weakness", "pos": [], "type": "" }, "tail": { "name": "trimethoprim", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them .
[ { "head": { "name": "Arrhythmias", "pos": [], "type": "" }, "tail": { "name": "amphotericin B", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "cardiac arrest", "pos": [], "type": "" }, "tail": { "name": "amphotericin B", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Fixed drug eruption to rofecoxib .
[ { "head": { "name": "Fixed drug eruption", "pos": [], "type": "" }, "tail": { "name": "rofecoxib", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Colonic mucosal necrosis following administration of calcium polystryrene sulfonate ( Kalimate ) in a uremic patient .
[ { "head": { "name": "Colonic mucosal necrosis", "pos": [], "type": "" }, "tail": { "name": "calcium polystryrene sulfonate", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "Colonic mucosal necrosis", "pos": [], "type": "" }, "tail": { "name": "Kalimate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Hypersensitivity to zonisamide was confirmed by the skin patch test .
[ { "head": { "name": "Hypersensitivity", "pos": [], "type": "" }, "tail": { "name": "zonisamide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Acute respiratory distress syndrome after rituximab infusion .
[ { "head": { "name": "Acute respiratory distress syndrome", "pos": [], "type": "" }, "tail": { "name": "rituximab", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
CONCLUSION : Healthcare professionals should be aware of the possible development of serotonin syndrome as a complication of initiation of fentanyl and other phenylpiperidine opioids in patients treated with SSRIs .
[ { "head": { "name": "serotonin syndrome", "pos": [], "type": "" }, "tail": { "name": "fentanyl", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We discuss the association between carbamazepine and hyponatremia and the causes of hyponatremia after cardiopulmonary bypass .
[ { "head": { "name": "hyponatremia", "pos": [], "type": "" }, "tail": { "name": "carbamazepine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]