sentence
stringlengths
9
1.35k
relations
listlengths
1
26
dataset
stringclasses
18 values
types
listlengths
1
24
Naproxen - associated sudden sensorineural hearing loss .
[ { "head": { "name": "sudden sensorineural hearing loss", "pos": [], "type": "" }, "tail": { "name": "Naproxen", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
An amiodarone optic neuropathy has been described .
[ { "head": { "name": "optic neuropathy", "pos": [], "type": "" }, "tail": { "name": "amiodarone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Treatment - related myelodysplastic syndrome after temozolomide for recurrent high - grade glioma .
[ { "head": { "name": "myelodysplastic syndrome", "pos": [], "type": "" }, "tail": { "name": "temozolomide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
CONCLUSION : Significant weight loss is a potential adverse event in patients with rheumatoid arthritis treated with leflunomide .
[ { "head": { "name": "weight loss", "pos": [], "type": "" }, "tail": { "name": "leflunomide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Hepatic angiosarcoma occurring after cyclophosphamide therapy : case report and review of the literature .
[ { "head": { "name": "Hepatic angiosarcoma", "pos": [], "type": "" }, "tail": { "name": "cyclophosphamide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
In this report , one patient who developed gangrene after bleomycin and vincristine / vinblastine chemotherapy for AIDS - related Kaposi 's sarcoma and another HIV - infected patient who exhibited symptoms of severe Raynaud 's phenomenon related to the same regimen are presented .
[ { "head": { "name": "gangrene", "pos": [], "type": "" }, "tail": { "name": "bleomycin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "gangrene", "pos": [], "type": "" }, "tail": { "name": "vinblastine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "gangrene", "pos": [], "type": "" }, "tail": { "name": "vincristine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "severe Raynaud 's phenomenon", "pos": [], "type": "" }, "tail": { "name": "bleomycin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "severe Raynaud 's phenomenon", "pos": [], "type": "" }, "tail": { "name": "vinblastine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "severe Raynaud 's phenomenon", "pos": [], "type": "" }, "tail": { "name": "vincristine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Carbamazepine - induced tics .
[ { "head": { "name": "tics", "pos": [], "type": "" }, "tail": { "name": "Carbamazepine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Successful recovery from interstitial pneumonitis , induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer .
[ { "head": { "name": "interstitial pneumonitis", "pos": [], "type": "" }, "tail": { "name": "bicalutamide", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "interstitial pneumonitis", "pos": [], "type": "" }, "tail": { "name": "leuprorelin acetate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Levofloxacin - induced toxic epidermal necrolysis in an elderly patient .
[ { "head": { "name": "toxic epidermal necrolysis", "pos": [], "type": "" }, "tail": { "name": "Levofloxacin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We describe 2 male patients , a 49-year - old with psoriatic arthritis and impaired renal function and a 43-year - old renal transplant recipient , who both sustained a marked decline in glomerular filtration rate in conjunction with a selective inhibitor of cyclooxygenase-2 ( COX-2 ) , rofecoxib .
[ { "head": { "name": "decline in glomerular filtration rate", "pos": [], "type": "" }, "tail": { "name": "rofecoxib", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The biochemistry of paracetamol hepatotoxicity is outlined and the increased susceptibility of alcoholic patients to the hepatotoxic effects of paracetamol is remarked upon .
[ { "head": { "name": "hepatotoxic effects", "pos": [], "type": "" }, "tail": { "name": "paracetamol", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hepatotoxicity", "pos": [], "type": "" }, "tail": { "name": "paracetamol", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Tenofovir - associated nephrotoxicity in two HIV - infected adolescent males .
[ { "head": { "name": "nephrotoxicity", "pos": [], "type": "" }, "tail": { "name": "Tenofovir", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Based on the Naranjo probability scale , serotonin syndrome was a probable adverse reaction associated with co - administration of citalopram and fentanyl .
[ { "head": { "name": "serotonin syndrome", "pos": [], "type": "" }, "tail": { "name": "citalopram", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "serotonin syndrome", "pos": [], "type": "" }, "tail": { "name": "fentanyl", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
This supports the well - reported potential of bleomycin to trigger acral vascular toxicity .
[ { "head": { "name": "acral vascular toxicity", "pos": [], "type": "" }, "tail": { "name": "bleomycin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Because of serious side effects of an increase in the QT interval causing torsades de pointes , dofetilide must be initiated with close monitoring of the QT interval in an inpatient setting .
[ { "head": { "name": "increase in the QT interval", "pos": [], "type": "" }, "tail": { "name": "dofetilide", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "torsades de pointes", "pos": [], "type": "" }, "tail": { "name": "dofetilide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Development of Crohn 's disease in a patient with multiple sclerosis treated with copaxone .
[ { "head": { "name": "Crohn 's disease", "pos": [], "type": "" }, "tail": { "name": "copaxone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
CONCLUSIONS : This patient 's rhabdomyolysis was probably induced by sertraline therapy .
[ { "head": { "name": "rhabdomyolysis", "pos": [], "type": "" }, "tail": { "name": "sertraline", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
PURPOSE : To present a case of respiratory depression following the administration of nebulised morphine .
[ { "head": { "name": "respiratory depression", "pos": [], "type": "" }, "tail": { "name": "morphine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
INTRODUCTION : Although gefitinib used for the treatment of non - small - cell lung cancer is a well - known cause of interstitial lung disease ( ILD ) , few case reports on erlotinib - induced ILD have been issued .
[ { "head": { "name": "ILD", "pos": [], "type": "" }, "tail": { "name": "gefitinib", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "ILD", "pos": [], "type": "" }, "tail": { "name": "erlotinib", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "interstitial lung disease", "pos": [], "type": "" }, "tail": { "name": "gefitinib", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Captopril - related ( and -induced ? ) asthma .
[ { "head": { "name": "asthma", "pos": [], "type": "" }, "tail": { "name": "Captopril", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We present the case of a 5-year - old girl who developed bilateral vocal cord paralysis following preoperative peritonsillar bupivacaine infiltration .
[ { "head": { "name": "bilateral vocal cord paralysis", "pos": [], "type": "" }, "tail": { "name": "bupivacaine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We describe a case of fibrosing alveolitis , diagnosed by lung biopsy , in a patient receiving amiodarone which responded to corticosteroid therapy .
[ { "head": { "name": "fibrosing alveolitis", "pos": [], "type": "" }, "tail": { "name": "amiodarone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
An unusual presentation of spontaneous sub - conjunctival haematoma in a patient receiving warfarin .
[ { "head": { "name": "sub - conjunctival haematoma", "pos": [], "type": "" }, "tail": { "name": "warfarin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
This case study describes an atypical case of refractory , sodium warfarin - induced necrotizing fasciitis and myonecrosis .
[ { "head": { "name": "myonecrosis", "pos": [], "type": "" }, "tail": { "name": "sodium warfarin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "necrotizing fasciitis", "pos": [], "type": "" }, "tail": { "name": "sodium warfarin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A case of noncardiogenic pulmonary edema by ethanolamine oleate .
[ { "head": { "name": "noncardiogenic pulmonary edema", "pos": [], "type": "" }, "tail": { "name": "ethanolamine oleate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The azathioprine dose was low ( 1 mg / kg ) and pancytopenia occurred after 56 days therapy .
[ { "head": { "name": "pancytopenia", "pos": [], "type": "" }, "tail": { "name": "azathioprine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A girl with cystic fibrosis and cyclic neutropenia developed an erythematous papular eruption without fever or neutrophilia 7 months after commencing therapy with G - CSF .
[ { "head": { "name": "erythematous papular eruption", "pos": [], "type": "" }, "tail": { "name": "G - CSF", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Although vasculitis has been reported in the course of hairy cell leukaemia , it has only rarely been reported as the consequence of cladribine treatment .
[ { "head": { "name": "vasculitis", "pos": [], "type": "" }, "tail": { "name": "cladribine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Cerebrovascular complications of L - asparaginase therapy in children with leukemia : aphasia and other neuropsychological deficits .
[ { "head": { "name": "aphasia", "pos": [], "type": "" }, "tail": { "name": "L - asparaginase", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "Cerebrovascular complications", "pos": [], "type": "" }, "tail": { "name": "L - asparaginase", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "neuropsychological deficits", "pos": [], "type": "" }, "tail": { "name": "L - asparaginase", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report a case of acute hyperphosphatemia secondary to rectal administration of sodium phosphate and sodium biphosphate ( Fleet enema ) .
[ { "head": { "name": "hyperphosphatemia", "pos": [], "type": "" }, "tail": { "name": "sodium biphosphate", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "hyperphosphatemia", "pos": [], "type": "" }, "tail": { "name": "sodium phosphate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Cardiac hypersensitivity and myopericarditis have been reported during long - term treatment with mesalazine .
[ { "head": { "name": "Cardiac hypersensitivity", "pos": [], "type": "" }, "tail": { "name": "mesalazine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "myopericarditis", "pos": [], "type": "" }, "tail": { "name": "mesalazine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
It carries a well - known risk of neutropenia and agranulocytosis , which necessitates the immediate discontinuation of clozapine .
[ { "head": { "name": "agranulocytosis", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "neutropenia", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Pemphigus foliaceus was seen in a patient with pulmonary tuberculosis during rifampicin therapy .
[ { "head": { "name": "Pemphigus foliaceus", "pos": [], "type": "" }, "tail": { "name": "rifampicin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
a 67-year - old man with bipolar disorder developed a Creutzfeldt - Jakob like syndrome during lithium carbonate treatment .
[ { "head": { "name": "Creutzfeldt - Jakob like syndrome", "pos": [], "type": "" }, "tail": { "name": "lithium carbonate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Physicians should therefore be aware of its occurrence and carefully monitor serum levels of CPK , GOT and GPT during the treatment of diabetes insipidus with clofibrate , especially in patients with associated hypothyroidism , latent or overt , which possibly favors the development of myopathy .
[ { "head": { "name": "myopathy", "pos": [], "type": "" }, "tail": { "name": "clofibrate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
An insulin - dependent diabetic patient with nephropathy developed severe acidosis after treatment with acetazolamide for glaucoma .
[ { "head": { "name": "severe acidosis", "pos": [], "type": "" }, "tail": { "name": "acetazolamide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The day after clozapine was stopped , while he was still receiving clomipramine 150 mg / d , he began behaving oddly , started sweating profusely , shivering , and became tremulous , agitated , and confused .
[ { "head": { "name": "agitated", "pos": [], "type": "" }, "tail": { "name": "clomipramine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "agitated", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "behaving oddly", "pos": [], "type": "" }, "tail": { "name": "clomipramine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "behaving oddly", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "confused", "pos": [], "type": "" }, "tail": { "name": "clomipramine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "confused", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "shivering", "pos": [], "type": "" }, "tail": { "name": "clomipramine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "shivering", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "sweating profusely", "pos": [], "type": "" }, "tail": { "name": "clomipramine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "sweating profusely", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "tremulous", "pos": [], "type": "" }, "tail": { "name": "clomipramine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "tremulous", "pos": [], "type": "" }, "tail": { "name": "clozapine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Moreover , these findings suggest that the incidence of BOOP following rituximab therapy may be higher than has been previously appreciated .
[ { "head": { "name": "BOOP", "pos": [], "type": "" }, "tail": { "name": "rituximab", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
A teenage girl with crescentic glomerulonephritis had antineutrophil cytoplasmic antibody ( ANCA ) detected after she had received propylthiouracil ( PTU ) for hyperthyroidism without cutaneous vasculitis .
[ { "head": { "name": "antineutrophil cytoplasmic antibody", "pos": [], "type": "" }, "tail": { "name": "propylthiouracil", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "antineutrophil cytoplasmic antibody", "pos": [], "type": "" }, "tail": { "name": "PTU", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report a 44-year - old woman with t - MDS ( refractory anemia with excess blasts ) following treatment of recurrent anaplastic astrocytoma with temozolomide ( TMZ ) .
[ { "head": { "name": "refractory anemia with excess blasts", "pos": [], "type": "" }, "tail": { "name": "temozolomide", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "refractory anemia with excess blasts", "pos": [], "type": "" }, "tail": { "name": "TMZ", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Cushing 's syndrome persisted more than 6 months while TCA concentrations remained detectable for at least 80 days .
[ { "head": { "name": "Cushing 's syndrome", "pos": [], "type": "" }, "tail": { "name": "TCA", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Severe adenovirus pneumonia ( AVP ) following infliximab infusion for the treatment of Crohn 's disease .
[ { "head": { "name": "AVP", "pos": [], "type": "" }, "tail": { "name": "infliximab", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "Severe adenovirus pneumonia", "pos": [], "type": "" }, "tail": { "name": "infliximab", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The disease - modifying drugs he was taking , cyclosporin and methotrexate , were stopped , and the lymphoma resolved spontaneously without the use of chemotherapy .
[ { "head": { "name": "lymphoma", "pos": [], "type": "" }, "tail": { "name": "cyclosporin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "lymphoma", "pos": [], "type": "" }, "tail": { "name": "methotrexate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Leflunomide - associated weight loss in rheumatoid arthritis .
[ { "head": { "name": "weight loss", "pos": [], "type": "" }, "tail": { "name": "Leflunomide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Several cases of lithium - induced Creutzfeldt - Jakob syndrome have been reported to date ; all of them were elderly patients and a half had " therapeutic " lithium serum levels .
[ { "head": { "name": "Creutzfeldt - Jakob syndrome", "pos": [], "type": "" }, "tail": { "name": "lithium", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "Creutzfeldt - Jakob syndrome", "pos": [], "type": "" }, "tail": { "name": "lithium", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Milk - alkali syndrome induced by 1,25(OH)2D in a patient with hypoparathyroidism .
[ { "head": { "name": "Milk - alkali syndrome", "pos": [], "type": "" }, "tail": { "name": "1,25(OH)2D", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
However , because diphenhydramine also exhibits type IA sodium channel blockade , cardiac toxicity is also possible .
[ { "head": { "name": "cardiac toxicity", "pos": [], "type": "" }, "tail": { "name": "diphenhydramine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
OBJECTIVE : To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram , as evidenced by medication history , clinical features and reversal following discontinuation of fentanyl .
[ { "head": { "name": "serotonin syndrome", "pos": [], "type": "" }, "tail": { "name": "citalopram", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "serotonin syndrome", "pos": [], "type": "" }, "tail": { "name": "fentanyl", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "serotonin syndrome", "pos": [], "type": "" }, "tail": { "name": "fentanyl", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21 .
[ { "head": { "name": "neutropenia", "pos": [], "type": "" }, "tail": { "name": "captopril", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Propafenone - induced ataxia : report of three cases .
[ { "head": { "name": "ataxia", "pos": [], "type": "" }, "tail": { "name": "Propafenone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
This article reports the case of an otherwise healthy patient who experienced permanent sensorineural hearing loss after a brief course of naproxen and reviews the literature on NSAID - related permanent sensorineural hearing loss .
[ { "head": { "name": "sensorineural hearing loss", "pos": [], "type": "" }, "tail": { "name": "naproxen", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Potential causes of methamphetamine - related keratitis can be divided into four categories resulting from ( a ) direct pharmacologic and physical effects of methamphetamine ; ( b ) the toxic effects of diluting or " cutting " agents such as lidocaine and quinine ; ( c ) effects related to the route of drug administration ( intravenous , inhalation , smoking ) ; and ( d ) manufacture - related effects of exposure to unintentional caustic contaminants in the final product .
[ { "head": { "name": "keratitis", "pos": [], "type": "" }, "tail": { "name": "lidocaine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "keratitis", "pos": [], "type": "" }, "tail": { "name": "methamphetamine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "keratitis", "pos": [], "type": "" }, "tail": { "name": "quinine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "toxic effects", "pos": [], "type": "" }, "tail": { "name": "lidocaine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "toxic effects", "pos": [], "type": "" }, "tail": { "name": "methamphetamine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "toxic effects", "pos": [], "type": "" }, "tail": { "name": "quinine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate .
[ { "head": { "name": "Lymphoma", "pos": [], "type": "" }, "tail": { "name": "methotrexate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Contact dermatitis due to budesonide : report of five cases and review of the Japanese literature .
[ { "head": { "name": "Contact dermatitis", "pos": [], "type": "" }, "tail": { "name": "budesonide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Herein we report four patients who underwent liver transplantation and developed neutropenia while receiving MMF .
[ { "head": { "name": "neutropenia", "pos": [], "type": "" }, "tail": { "name": "MMF", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Accordingly , camptocormia is a dose - dependent side effect of valproate .
[ { "head": { "name": "camptocormia", "pos": [], "type": "" }, "tail": { "name": "valproate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Myoglobinuria and acute renal failure were observed in two patients with vasopressin - treated gastrointestinal hemorrhage .
[ { "head": { "name": "acute renal failure", "pos": [], "type": "" }, "tail": { "name": "vasopressin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "Myoglobinuria", "pos": [], "type": "" }, "tail": { "name": "vasopressin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Carbamazepine - induced systemic lupus erythematosus - like disease .
[ { "head": { "name": "systemic lupus erythematosus - like disease", "pos": [], "type": "" }, "tail": { "name": "Carbamazepine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Acute eosinophilic pneumonia caused by calcium stearate , an additive agent for an oral antihistaminic medication .
[ { "head": { "name": "Acute eosinophilic pneumonia", "pos": [], "type": "" }, "tail": { "name": "calcium stearate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
This report suggests that anemia can occur due to MMF , in particular when it is given with prednisone , a side effect well documented in the transplantation literature when the triple combination of MMF , cyclosporine and prednisone is used .
[ { "head": { "name": "anemia", "pos": [], "type": "" }, "tail": { "name": "cyclosporine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "anemia", "pos": [], "type": "" }, "tail": { "name": "MMF", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "anemia", "pos": [], "type": "" }, "tail": { "name": "MMF", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "anemia", "pos": [], "type": "" }, "tail": { "name": "prednisone", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "anemia", "pos": [], "type": "" }, "tail": { "name": "prednisone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
FK506 , which began to be administered 12 days earlier , rose to a level of 44 ng / mL ( normal range , 10 - 20 ng / mL ) 1 day before neurologic abnormalities began .
[ { "head": { "name": "neurologic abnormalities", "pos": [], "type": "" }, "tail": { "name": "FK506", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We believe that these skin eruptions belong to a spectrum of neutrophilic dermatoses that can be induced or aggravated by G - CSF therapy .
[ { "head": { "name": "neutrophilic dermatoses", "pos": [], "type": "" }, "tail": { "name": "G - CSF", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "skin eruptions", "pos": [], "type": "" }, "tail": { "name": "G - CSF", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Metamizole , a nonsteroidal antiinflammatory agent , is prohibited in the United States because of the risk of agranulocytosis but is widely used in Mexico and other countries .
[ { "head": { "name": "agranulocytosis", "pos": [], "type": "" }, "tail": { "name": "Metamizole", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Albendazole - induced pseudomembranous colitis .
[ { "head": { "name": "pseudomembranous colitis", "pos": [], "type": "" }, "tail": { "name": "Albendazole", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
In this paper we report a case of nimodipine overdosage resulting in prolonged hypotension and hypoxemia , which was successfully treated with calcium gluconate .
[ { "head": { "name": "hypoxemia", "pos": [], "type": "" }, "tail": { "name": "nimodipine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "prolonged hypotension", "pos": [], "type": "" }, "tail": { "name": "nimodipine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
This case suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA .
[ { "head": { "name": "extramedullary relapse", "pos": [], "type": "" }, "tail": { "name": "ATRA", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Suspected ciprofloxacin - induced interstitial nephritis .
[ { "head": { "name": "interstitial nephritis", "pos": [], "type": "" }, "tail": { "name": "ciprofloxacin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Other thiazolidinediones currently in clinical trials may be able to provide the therapeutic benefits of troglitazone without significant hepatotoxicity .
[ { "head": { "name": "hepatotoxicity", "pos": [], "type": "" }, "tail": { "name": "troglitazone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report ( to our knowledge , for the first time in a child ) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516 T .
[ { "head": { "name": "psychosis", "pos": [], "type": "" }, "tail": { "name": "efavirenz", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The mechanism of the decrease in plasma potassium induced by phosphate treatment was investigated in a 24-year - old hypertensive patient with hypophosphatemic osteomalacia , who was the youngest of four patients , belonging to a 23 number kindred of five generations .
[ { "head": { "name": "decrease in plasma potassium", "pos": [], "type": "" }, "tail": { "name": "phosphate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report a case of reversible encephalopathy syndrome in a 16-year - old girl with acute myelogenous leukemia ( AML ) , who is undergoing during consolidation chemotherapy composed of BH - AC ( N4-behenoyl-1-beta - D - arabinofuranosyl cytosine ) and idarubicin .
[ { "head": { "name": "encephalopathy syndrome", "pos": [], "type": "" }, "tail": { "name": "BH - AC", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "encephalopathy syndrome", "pos": [], "type": "" }, "tail": { "name": "idarubicin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Papillary necrosis associated with the HIV protease inhibitor indinavir .
[ { "head": { "name": "Papillary necrosis", "pos": [], "type": "" }, "tail": { "name": "indinavir", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Interstitial granulomatous dermatitis associated with darifenacin .
[ { "head": { "name": "Interstitial granulomatous dermatitis", "pos": [], "type": "" }, "tail": { "name": "darifenacin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
METHODS : Growth retardation was observed in six severely asthmatic children after introduction of high - dose fluticasone propionate treatment ( dry powder ) .
[ { "head": { "name": "Growth retardation", "pos": [], "type": "" }, "tail": { "name": "fluticasone propionate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The ampicillin rash occurring in cases of infectious mononucleosis is well documented .
[ { "head": { "name": "ampicillin rash", "pos": [], "type": "" }, "tail": { "name": "ampicillin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Although useful in the management of chronic alcoholism , disulfiram is being increasingly associated with a wide spectrum of side effects and untoward medical sequelae , which now include catatonia .
[ { "head": { "name": "catatonia", "pos": [], "type": "" }, "tail": { "name": "disulfiram", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
These are the first reported patients to show mfERG abnormalities that correspond to bitemporal visual field defects and add to the growing evidence that ethambutol damages the retina .
[ { "head": { "name": "bitemporal visual field defects", "pos": [], "type": "" }, "tail": { "name": "ethambutol", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "mfERG abnormalities", "pos": [], "type": "" }, "tail": { "name": "ethambutol", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Mycophenolate mofetil - induced neutropenia in liver transplantation .
[ { "head": { "name": "neutropenia", "pos": [], "type": "" }, "tail": { "name": "Mycophenolate mofetil", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Progressive pulmonary fibrosis complicating cyclophosphamide therapy .
[ { "head": { "name": "Progressive pulmonary fibrosis", "pos": [], "type": "" }, "tail": { "name": "cyclophosphamide", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Drug - induced mammary hyperplasias have been reported as rare complications of D - penicillamine and Neothetazone .
[ { "head": { "name": "mammary hyperplasias", "pos": [], "type": "" }, "tail": { "name": "D - penicillamine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "mammary hyperplasias", "pos": [], "type": "" }, "tail": { "name": "Neothetazone", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
She was treated with acyclovir and subsequently developed VZV antigen - positive zoster .
[ { "head": { "name": "VZV antigen - positive zoster", "pos": [], "type": "" }, "tail": { "name": "acyclovir", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
RESULTS : All cases developed corneal endothelial deposits after previous use of rifabutin .
[ { "head": { "name": "corneal endothelial deposits", "pos": [], "type": "" }, "tail": { "name": "rifabutin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
OBJECTIVE : The purpose of this study was to determine whether desensitization to NPH insulin , as well as standard insulin desensitization , could control allergic symptoms in a patient allergic to both NPH and regular insulin .
[ { "head": { "name": "allergic symptoms", "pos": [], "type": "" }, "tail": { "name": "insulin", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "allergic symptoms", "pos": [], "type": "" }, "tail": { "name": "NPH insulin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin , and was subsequently given epinephrine by mistake intravenously rather than subcutaneously .
[ { "head": { "name": "acute myocardial ischemia", "pos": [], "type": "" }, "tail": { "name": "epinephrine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "severe allergic reaction", "pos": [], "type": "" }, "tail": { "name": "epinephrine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "severe allergic reaction", "pos": [], "type": "" }, "tail": { "name": "epinephrine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Dipyrone , also known as metamizole , is an analgesic and antipyretic drug that was banned by the United States Food and Drug Administration because of its association with agranulocytosis .
[ { "head": { "name": "agranulocytosis", "pos": [], "type": "" }, "tail": { "name": "Dipyrone", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "agranulocytosis", "pos": [], "type": "" }, "tail": { "name": "metamizole", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Prolonged used of hydroxyurea in patients with ET may lead to therapy - associated acute leukemia .
[ { "head": { "name": "acute leukemia", "pos": [], "type": "" }, "tail": { "name": "hydroxyurea", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Carbamazepine - induced hyperammonemia .
[ { "head": { "name": "hyperammonemia", "pos": [], "type": "" }, "tail": { "name": "Carbamazepine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
OBJECTIVE : To document a case of serotonin syndrome ( SS ) associated with mirtazapine monotherapy , review the previously reported cases of SS associated with this tetracyclic antidepressant , and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction .
[ { "head": { "name": "serotonin syndrome", "pos": [], "type": "" }, "tail": { "name": "mirtazapine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "SS", "pos": [], "type": "" }, "tail": { "name": "mirtazapine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
The delayed encephalopathy developed 9 and 22 months respectively after the first dose of intrathecal methotrexate .
[ { "head": { "name": "encephalopathy", "pos": [], "type": "" }, "tail": { "name": "methotrexate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We believe that the acute renal failure in our patient was associated with anastrozole .
[ { "head": { "name": "acute renal failure", "pos": [], "type": "" }, "tail": { "name": "anastrozole", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Parenteral - verapamil - induced sustained hypotension .
[ { "head": { "name": "sustained hypotension", "pos": [], "type": "" }, "tail": { "name": "verapamil", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Piloerection induced by replacing fluvoxamine with milnacipran .
[ { "head": { "name": "Piloerection", "pos": [], "type": "" }, "tail": { "name": "fluvoxamine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "Piloerection", "pos": [], "type": "" }, "tail": { "name": "milnacipran", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Sodium valproate and carbamazepine , antiepileptic drugs that are associated with a relatively low rate of adverse cutaneous reactions , should be added to the growing list of drugs that produce psoriasiform eruptions .
[ { "head": { "name": "psoriasiform eruptions", "pos": [], "type": "" }, "tail": { "name": "carbamazepine", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "psoriasiform eruptions", "pos": [], "type": "" }, "tail": { "name": "Sodium valproate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
In each of the three reported patients , alteration of eyelid appearance with deepening of the lid sulcus was evident as the result of topical bimatoprost therapy .
[ { "head": { "name": "alteration of eyelid appearance", "pos": [], "type": "" }, "tail": { "name": "bimatoprost", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "deepening of the lid sulcus", "pos": [], "type": "" }, "tail": { "name": "bimatoprost", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We highlight two instances of systemic allergic reaction , and discuss the potential side effects of local aprotinin injections in the orthopaedic setting as well as the evidence base for its use .
[ { "head": { "name": "systemic allergic reaction", "pos": [], "type": "" }, "tail": { "name": "aprotinin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia .
[ { "head": { "name": "akathisia", "pos": [], "type": "" }, "tail": { "name": "fluoxetine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
We report the case of a 14-year - old female with acute promyelocytic leukemia who developed symptomatic cardiomyopathy only 4 months into treatment with a combination of daunomycin and all - trans retinoic acid ( ATRA ) .
[ { "head": { "name": "symptomatic cardiomyopathy", "pos": [], "type": "" }, "tail": { "name": "all - trans retinoic acid", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "symptomatic cardiomyopathy", "pos": [], "type": "" }, "tail": { "name": "ATRA", "pos": [], "type": "" }, "type": "adverse effect" }, { "head": { "name": "symptomatic cardiomyopathy", "pos": [], "type": "" }, "tail": { "name": "daunomycin", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Protamine - induced fatal anaphylaxis .
[ { "head": { "name": "fatal anaphylaxis", "pos": [], "type": "" }, "tail": { "name": "Protamine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
Liver disease induced by perhexiline maleate .
[ { "head": { "name": "Liver disease", "pos": [], "type": "" }, "tail": { "name": "perhexiline maleate", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]
So far , few cases of pulmonary side effects caused by ticlopidine have been reported .
[ { "head": { "name": "pulmonary side effects", "pos": [], "type": "" }, "tail": { "name": "ticlopidine", "pos": [], "type": "" }, "type": "adverse effect" } ]
ADE_corpus
[ "adverse effect" ]