sentence
stringlengths 9
1.35k
| relations
listlengths 1
26
| dataset
stringclasses 18
values | types
listlengths 1
24
|
|---|---|---|---|
Uveitis during treatment of disseminated Mycobacterium avium - intracellulare complex infection with the combination of rifabutin , clarithromycin and ethambutol .
|
[
{
"head": {
"name": "Uveitis",
"pos": [],
"type": ""
},
"tail": {
"name": "clarithromycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Uveitis",
"pos": [],
"type": ""
},
"tail": {
"name": "ethambutol",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Uveitis",
"pos": [],
"type": ""
},
"tail": {
"name": "rifabutin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Propylthiouracil - induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies .
|
[
{
"head": {
"name": "antineutrophil cytoplasmic antibodies",
"pos": [],
"type": ""
},
"tail": {
"name": "Propylthiouracil",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "sensorineural hearing loss",
"pos": [],
"type": ""
},
"tail": {
"name": "Propylthiouracil",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We report a case of MMC - related hemolytic uremic syndrome , and discuss the etiologic parameters , clinical aspects , prognosis and treatment modalities of this severe syndrome .
|
[
{
"head": {
"name": "hemolytic uremic syndrome",
"pos": [],
"type": ""
},
"tail": {
"name": "MMC",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
CONCLUSIONS : We report the first case of gemcitabine - induced LABD .
|
[
{
"head": {
"name": "LABD",
"pos": [],
"type": ""
},
"tail": {
"name": "gemcitabine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
A lethal complication of peripheral vein vasopressin infusion .
|
[
{
"head": {
"name": "lethal complication",
"pos": [],
"type": ""
},
"tail": {
"name": "vasopressin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Fortunately , a hypersensitivity reaction to one formulation of cyclosporine does not preclude use of a different formulation .
|
[
{
"head": {
"name": "hypersensitivity reaction",
"pos": [],
"type": ""
},
"tail": {
"name": "cyclosporine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Ampicillin may aggravate clinical and experimental myasthenia gravis .
|
[
{
"head": {
"name": "myasthenia gravis",
"pos": [],
"type": ""
},
"tail": {
"name": "Ampicillin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Ectropion secondary to bolus injection of 5-fluorouracil .
|
[
{
"head": {
"name": "Ectropion",
"pos": [],
"type": ""
},
"tail": {
"name": "5-fluorouracil",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Atrioventricular block complicating amiodarone - induced hypothyroidism in a patient with pre - excitation and rate - dependent bilateral bundle branch block .
|
[
{
"head": {
"name": "Atrioventricular block",
"pos": [],
"type": ""
},
"tail": {
"name": "amiodarone",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "hypothyroidism",
"pos": [],
"type": ""
},
"tail": {
"name": "amiodarone",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
After discontinuation of danazol the diabetes completely resolved .
|
[
{
"head": {
"name": "diabetes",
"pos": [],
"type": ""
},
"tail": {
"name": "danazol",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Recurrent hyponatremia associated with citalopram and mirtazapine .
|
[
{
"head": {
"name": "Recurrent hyponatremia",
"pos": [],
"type": ""
},
"tail": {
"name": "citalopram",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Recurrent hyponatremia",
"pos": [],
"type": ""
},
"tail": {
"name": "mirtazapine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The harlequin color change and association with prostaglandin E1 .
|
[
{
"head": {
"name": "harlequin color change",
"pos": [],
"type": ""
},
"tail": {
"name": "prostaglandin E1",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The dose - limiting toxicity of KW-2149 is pulmonary toxicity .
|
[
{
"head": {
"name": "pulmonary toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "KW-2149",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The second patient developed both autoimmune thyroid disease and a refractory pre - patellar bursitis after 50 months of IFN - beta therapy .
|
[
{
"head": {
"name": "autoimmune thyroid disease",
"pos": [],
"type": ""
},
"tail": {
"name": "IFN - beta",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "refractory pre - patellar bursitis",
"pos": [],
"type": ""
},
"tail": {
"name": "IFN - beta",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
After receiving 3 doses of ifosfamide / mesna , she was found to be unresponsive .
|
[
{
"head": {
"name": "unresponsive",
"pos": [],
"type": ""
},
"tail": {
"name": "ifosfamide",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "unresponsive",
"pos": [],
"type": ""
},
"tail": {
"name": "mesna",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
This case report illustrates the neurotoxicity unique to HDARAC .
|
[
{
"head": {
"name": "neurotoxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "HDARAC",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Squamous - cell carcinoma arising in a basal - cell epithelioma treated with 5-fluorouracil .
|
[
{
"head": {
"name": "Squamous - cell carcinoma",
"pos": [],
"type": ""
},
"tail": {
"name": "5-fluorouracil",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Therefore , although garenoxacin reportedly causes fewer adverse reactions for cardiac rhythms than third - generation quinolone antibiotics , one must be cautious of the interference of other drugs during hypokalemia in order to prevent TdP .
|
[
{
"head": {
"name": "cardiac rhythms",
"pos": [],
"type": ""
},
"tail": {
"name": "garenoxacin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "hypokalemia",
"pos": [],
"type": ""
},
"tail": {
"name": "garenoxacin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Interstitial pneumonia probably associated with sorafenib treatment : An alert of an adverse event .
|
[
{
"head": {
"name": "Interstitial pneumonia",
"pos": [],
"type": ""
},
"tail": {
"name": "sorafenib",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Recombinant VIIa concentrate in the management of bleeding following prothrombin complex concentrate - related myocardial infarction in patients with haemophilia and inhibitors .
|
[
{
"head": {
"name": "myocardial infarction",
"pos": [],
"type": ""
},
"tail": {
"name": "prothrombin complex concentrate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
46-year - old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis .
|
[
{
"head": {
"name": "painful ulcers",
"pos": [],
"type": ""
},
"tail": {
"name": "interferon beta-1b",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "reticulate erythema",
"pos": [],
"type": ""
},
"tail": {
"name": "interferon beta-1b",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Lansoprazole - induced thrombocytopenia .
|
[
{
"head": {
"name": "thrombocytopenia",
"pos": [],
"type": ""
},
"tail": {
"name": "Lansoprazole",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The major side effect of infliximab is infection .
|
[
{
"head": {
"name": "infection",
"pos": [],
"type": ""
},
"tail": {
"name": "infliximab",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
A case of severe visual loss following a single dose of vincristine is described .
|
[
{
"head": {
"name": "severe visual loss",
"pos": [],
"type": ""
},
"tail": {
"name": "vincristine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Renal tubular acidosis secondary to FK506 in living donor liver transplantation : a case report .
|
[
{
"head": {
"name": "Renal tubular acidosis",
"pos": [],
"type": ""
},
"tail": {
"name": "FK506",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
An 11-year - old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft - versus - host disease .
|
[
{
"head": {
"name": "severe enteropathy",
"pos": [],
"type": ""
},
"tail": {
"name": "clofazimine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
CASE REPORT : We report a case of intracerebral hemorrhage occurring in a middle - aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year .
|
[
{
"head": {
"name": "intracerebral hemorrhage",
"pos": [],
"type": ""
},
"tail": {
"name": "pseudoephedrine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
She was placed on adjuvant Adriamycin ( doxorubicin ) chemotherapy , but 6 months later died of Adriamycin toxicity .
|
[
{
"head": {
"name": "Adriamycin toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "Adriamycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Adriamycin toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "Adriamycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Adriamycin toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "doxorubicin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "died",
"pos": [],
"type": ""
},
"tail": {
"name": "Adriamycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "died",
"pos": [],
"type": ""
},
"tail": {
"name": "Adriamycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "died",
"pos": [],
"type": ""
},
"tail": {
"name": "doxorubicin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol .
|
[
{
"head": {
"name": "colonic ulcer",
"pos": [],
"type": ""
},
"tail": {
"name": "calcium polystyrene sulfonate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "colonic ulcer",
"pos": [],
"type": ""
},
"tail": {
"name": "sorbitol",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "sigmoidovesical fistula",
"pos": [],
"type": ""
},
"tail": {
"name": "calcium polystyrene sulfonate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "sigmoidovesical fistula",
"pos": [],
"type": ""
},
"tail": {
"name": "sorbitol",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis , desquamating dermatitis , prolonged myelosuppression , and neurologic toxicity that required admission to the intensive care unit .
|
[
{
"head": {
"name": "neurologic toxicity",
"pos": [],
"type": ""
},
"tail": {
"name": "5-FU",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "prolonged myelosuppression",
"pos": [],
"type": ""
},
"tail": {
"name": "5-FU",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "severe mucositis",
"pos": [],
"type": ""
},
"tail": {
"name": "5-FU",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Recently , CD20-negative tumors have been described after Rituximab therapy .
|
[
{
"head": {
"name": "CD20-negative tumors",
"pos": [],
"type": ""
},
"tail": {
"name": "Rituximab",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
However , prolongation of 5-FU half - life and an increase in INR have been reported with the concurrent use of 5-FU and warfarin .
|
[
{
"head": {
"name": "increase in INR",
"pos": [],
"type": ""
},
"tail": {
"name": "5-FU",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "increase in INR",
"pos": [],
"type": ""
},
"tail": {
"name": "warfarin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate .
|
[
{
"head": {
"name": "Fatal acute encephalomyelitis",
"pos": [],
"type": ""
},
"tail": {
"name": "methotrexate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Hepatic reactions to cyclofenil .
|
[
{
"head": {
"name": "Hepatic reactions",
"pos": [],
"type": ""
},
"tail": {
"name": "cyclofenil",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
This patient , who had a history of osteoarthritis , had severe hepatitis 5 weeks after being started on diclofenac for increasing pain in the joints .
|
[
{
"head": {
"name": "hepatitis",
"pos": [],
"type": ""
},
"tail": {
"name": "diclofenac",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
CONCLUSIONS : Peripheral administration of low - dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications .
|
[
{
"head": {
"name": "ischemic skin complications",
"pos": [],
"type": ""
},
"tail": {
"name": "vasopressin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Two of our patients developed TD after 23 months and 34 months of ziprasidone monotherapy , respectively .
|
[
{
"head": {
"name": "TD",
"pos": [],
"type": ""
},
"tail": {
"name": "ziprasidone",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Worsening of neurologic syndrome in patients with Wilson 's disease with initial penicillamine therapy .
|
[
{
"head": {
"name": "Worsening of neurologic syndrome",
"pos": [],
"type": ""
},
"tail": {
"name": "penicillamine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Because the combination of bleomycin and vinca alkaloids is commonly used for the treatment of AIDS - related Kaposi 's sarcoma , clinicians should be aware of the risk of provoking acral necrosis in patients who develop Raynaud 's phenomenon under chemotherapy .
|
[
{
"head": {
"name": "acral necrosis",
"pos": [],
"type": ""
},
"tail": {
"name": "bleomycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Raynaud 's phenomenon",
"pos": [],
"type": ""
},
"tail": {
"name": "bleomycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis .
|
[
{
"head": {
"name": "Systemic lupus erythematosus",
"pos": [],
"type": ""
},
"tail": {
"name": "penicillamine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
OBJECTIVE : To describe a case of sertraline - induced rhabdomyolysis in an elderly patient with dementia and comorbidities .
|
[
{
"head": {
"name": "rhabdomyolysis",
"pos": [],
"type": ""
},
"tail": {
"name": "sertraline",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The cases of CBZ - induced SLE reported in the literature were reviewed .
|
[
{
"head": {
"name": "SLE",
"pos": [],
"type": ""
},
"tail": {
"name": "CBZ",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
L - asparaginase - induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia .
|
[
{
"head": {
"name": "lethal complication",
"pos": [],
"type": ""
},
"tail": {
"name": "L - asparaginase",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "pancreatitis",
"pos": [],
"type": ""
},
"tail": {
"name": "L - asparaginase",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
It was highly suspected that finasteride was associated with the anterior subcapsular opacity on the lens , and the patient therefore discontinued use of finasteride .
|
[
{
"head": {
"name": "anterior subcapsular opacity on the lens",
"pos": [],
"type": ""
},
"tail": {
"name": "finasteride",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "anterior subcapsular opacity on the lens",
"pos": [],
"type": ""
},
"tail": {
"name": "finasteride",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
This is the first report of a possible association between an acute cardiovascular event and venlafaxine .
|
[
{
"head": {
"name": "acute cardiovascular event",
"pos": [],
"type": ""
},
"tail": {
"name": "venlafaxine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Restless legs syndrome may thus be an adverse effect of IFN alpha treatment .
|
[
{
"head": {
"name": "Restless legs syndrome",
"pos": [],
"type": ""
},
"tail": {
"name": "IFN alpha",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Rebound hyperglycemia was observed with both intermediate ( neutral protamine hagedorn ) and long - acting ( protamine zinc iletin ) insulins , and the range of insulin doses at which the disorder developed overlapped previously determined therapeutic doses for these insulins in the cat .
|
[
{
"head": {
"name": "Rebound hyperglycemia",
"pos": [],
"type": ""
},
"tail": {
"name": "protamine hagedorn",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Rebound hyperglycemia",
"pos": [],
"type": ""
},
"tail": {
"name": "protamine zinc iletin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Hepato - biliary abnormalities secondary to ceftriaxone use : a case report .
|
[
{
"head": {
"name": "Hepato - biliary abnormalities",
"pos": [],
"type": ""
},
"tail": {
"name": "ceftriaxone",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Unusual pigmentary changes associated with 5-fluorouracil therapy .
|
[
{
"head": {
"name": "pigmentary changes",
"pos": [],
"type": ""
},
"tail": {
"name": "5-fluorouracil",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
DISCUSSION : After exclusion of other causes , the onset of thrombocytopenia after administration of lansoprazole , the resolution of the adverse reaction after discontinuation of the drug , and the fact that no other medicines were introduced during this time frame lead us to believe that this was most likely an idiosyncratic thrombocytopenic response to lansoprazole .
|
[
{
"head": {
"name": "thrombocytopenia",
"pos": [],
"type": ""
},
"tail": {
"name": "lansoprazole",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "thrombocytopenic",
"pos": [],
"type": ""
},
"tail": {
"name": "lansoprazole",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
While on a maximal dose of phenylephrine she developed prominent positive U waves , which disappeared with the cessation of the drug .
|
[
{
"head": {
"name": "positive U waves",
"pos": [],
"type": ""
},
"tail": {
"name": "phenylephrine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Ticlopidine - induced interstitial pulmonary disease : a case report .
|
[
{
"head": {
"name": "interstitial pulmonary disease",
"pos": [],
"type": ""
},
"tail": {
"name": "Ticlopidine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy .
|
[
{
"head": {
"name": "Acute lung injury",
"pos": [],
"type": ""
},
"tail": {
"name": "5-fluorouracil",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Acute lung injury",
"pos": [],
"type": ""
},
"tail": {
"name": "oxaliplatinum",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
METHODS : Three patients with apparent itraconazole - induced liver injury were studied .
|
[
{
"head": {
"name": "liver injury",
"pos": [],
"type": ""
},
"tail": {
"name": "itraconazole",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
BACKGROUND : Hypersensitivity reactions to cyclosporine are rare .
|
[
{
"head": {
"name": "Hypersensitivity reactions",
"pos": [],
"type": ""
},
"tail": {
"name": "cyclosporine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The development of an IgG lambda - type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin ( DILANTIN ) therapy for 20 years is reported .
|
[
{
"head": {
"name": "IgG lambda - type monoclonal gammopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "DILANTIN",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "IgG lambda - type monoclonal gammopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "diphenylhydantoin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "multiple myeloma",
"pos": [],
"type": ""
},
"tail": {
"name": "DILANTIN",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "multiple myeloma",
"pos": [],
"type": ""
},
"tail": {
"name": "diphenylhydantoin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Case 2 , a 29-year - old woman , developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia .
|
[
{
"head": {
"name": "bilateral optic neuritis",
"pos": [],
"type": ""
},
"tail": {
"name": "recombinant interferon alpha-2b",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "bowel and bladder dysfunction",
"pos": [],
"type": ""
},
"tail": {
"name": "recombinant interferon alpha-2b",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "numbness of the lower extremities",
"pos": [],
"type": ""
},
"tail": {
"name": "recombinant interferon alpha-2b",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment .
|
[
{
"head": {
"name": "longitudinal melanonychia",
"pos": [],
"type": ""
},
"tail": {
"name": "hydroxyurea",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "multiple skin cancers",
"pos": [],
"type": ""
},
"tail": {
"name": "hydroxyurea",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
To the best of the authors ' knowledge , this is the first reported case of Propecia - associated cataract .
|
[
{
"head": {
"name": "cataract",
"pos": [],
"type": ""
},
"tail": {
"name": "Propecia",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The most likely cause of liver failure in this patient was , therefore , clarithromycin , which undergoes hepatic metabolism and has been reported to cause fulminant hepatic failure .
|
[
{
"head": {
"name": "fulminant hepatic failure",
"pos": [],
"type": ""
},
"tail": {
"name": "clarithromycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "liver failure",
"pos": [],
"type": ""
},
"tail": {
"name": "clarithromycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin - D and mithramycin .
|
[
{
"head": {
"name": "Cardiomyopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "actinomycin - D",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Cardiomyopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "adriamycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Cardiomyopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "mithramycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Lichen planus and acne provoked by gold .
|
[
{
"head": {
"name": "acne",
"pos": [],
"type": ""
},
"tail": {
"name": "gold",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Lichen planus",
"pos": [],
"type": ""
},
"tail": {
"name": "gold",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Acute ischaemia of the leg following accidental intra - arterial injection of dissolved flunitrazepam tablets .
|
[
{
"head": {
"name": "Acute ischaemia of the leg",
"pos": [],
"type": ""
},
"tail": {
"name": "flunitrazepam",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
In four patients , thrombosis occurred 2 - 45 days after severe hepatic veno - occlusive disease ( HVOD ) secondary to intensive chemotherapy containing busulfan .
|
[
{
"head": {
"name": "hepatic veno - occlusive disease",
"pos": [],
"type": ""
},
"tail": {
"name": "busulfan",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "HVOD",
"pos": [],
"type": ""
},
"tail": {
"name": "busulfan",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "thrombosis",
"pos": [],
"type": ""
},
"tail": {
"name": "busulfan",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Risperidone - induced psychosis and depression in a child with a mitochondrial disorder .
|
[
{
"head": {
"name": "depression",
"pos": [],
"type": ""
},
"tail": {
"name": "Risperidone",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "psychosis",
"pos": [],
"type": ""
},
"tail": {
"name": "Risperidone",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Cutaneous rashes and eruptions can be caused by many medications , including carbamazepine .
|
[
{
"head": {
"name": "Cutaneous rashes",
"pos": [],
"type": ""
},
"tail": {
"name": "carbamazepine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "eruptions",
"pos": [],
"type": ""
},
"tail": {
"name": "carbamazepine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
In this case , it was suspected that a combination of cigarette smoking , pulmonary fibrosis , and low - dose methotrexate therapy might have promoted the development of lung cancer .
|
[
{
"head": {
"name": "lung cancer",
"pos": [],
"type": ""
},
"tail": {
"name": "methotrexate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We describe a 63 year old woman with a suppurative mediastinitis , treated with continuous PI irrigation who developed an acute oliguric renal failure .
|
[
{
"head": {
"name": "acute oliguric renal failure",
"pos": [],
"type": ""
},
"tail": {
"name": "PI",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We recommend that a TMA in association with quinine be consistently referred to as quinine - associated thrombotic microangiopathy ( quinine - TMA ) to better distinguish this entity from idiopathic TTP .
|
[
{
"head": {
"name": "thrombotic microangiopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "quinine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Fever caused by the use of furosemide was proved ; the fever resolved after discontinuation of this medication and recurred after its reintroduction .
|
[
{
"head": {
"name": "Fever",
"pos": [],
"type": ""
},
"tail": {
"name": "furosemide",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
CASE REPORT : We present a case of a 28-yr - old male who developed a severe case of nephrotic syndrome while being treated for relapsing / remitting Multiple Sclerosis ( RRMS ) with weekly injections of interferon beta 1a .
|
[
{
"head": {
"name": "nephrotic syndrome",
"pos": [],
"type": ""
},
"tail": {
"name": "interferon beta 1a",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We describe a patient with rheumatoid arthritis treated with gold salts , who developed bilateral interstitial pulmonary abnormalities and showed a dramatic response on corticosteroid therapy .
|
[
{
"head": {
"name": "bilateral interstitial pulmonary abnormalities",
"pos": [],
"type": ""
},
"tail": {
"name": "gold",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Severe C. difficile colitis occurred in 2 patients ( 6.1 % ) after receiving cisplatin - based combination chemotherapy for ovarian malignancies .
|
[
{
"head": {
"name": "C. difficile colitis",
"pos": [],
"type": ""
},
"tail": {
"name": "cisplatin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
However , acute cardiomyopathy and pericarditis secondary to methylphenidate use has been rarely reported .
|
[
{
"head": {
"name": "acute cardiomyopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "methylphenidate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "pericarditis",
"pos": [],
"type": ""
},
"tail": {
"name": "methylphenidate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Metformin - associated lactic acidosis precipitated by diarrhea .
|
[
{
"head": {
"name": "lactic acidosis",
"pos": [],
"type": ""
},
"tail": {
"name": "Metformin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Gastro - oesophageal reflux associated with nifedipine .
|
[
{
"head": {
"name": "Gastro - oesophageal reflux",
"pos": [],
"type": ""
},
"tail": {
"name": "nifedipine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin - mediated vasodilatation , hyperalgesia of sensory nerve receptors , and potentiation of inflammation in the gingiva with referral of pain to the teeth .
|
[
{
"head": {
"name": "hyperalgesia of sensory nerve receptors",
"pos": [],
"type": ""
},
"tail": {
"name": "niacin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "pain to the teeth",
"pos": [],
"type": ""
},
"tail": {
"name": "niacin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "potentiation of inflammation in the gingiva",
"pos": [],
"type": ""
},
"tail": {
"name": "niacin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "prostaglandin - mediated vasodilatation",
"pos": [],
"type": ""
},
"tail": {
"name": "niacin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Minocycline - induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis .
|
[
{
"head": {
"name": "autoimmune hepatitis",
"pos": [],
"type": ""
},
"tail": {
"name": "Minocycline",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Ampicillin - associated seizures .
|
[
{
"head": {
"name": "seizures",
"pos": [],
"type": ""
},
"tail": {
"name": "Ampicillin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Severe steroid - induced glaucoma following intravitreal injection of triamcinolone acetonide .
|
[
{
"head": {
"name": "glaucoma",
"pos": [],
"type": ""
},
"tail": {
"name": "steroid",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "glaucoma",
"pos": [],
"type": ""
},
"tail": {
"name": "triamcinolone acetonide",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
METHOD : Case analysis of a poly - drug overdose ( venlafaxine , topiramate , divalproex sodium , risperidone , and carbamazepine ) presenting with mixed SS / NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS / NMS in critical care settings .
|
[
{
"head": {
"name": "NMS",
"pos": [],
"type": ""
},
"tail": {
"name": "carbamazepine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "NMS",
"pos": [],
"type": ""
},
"tail": {
"name": "divalproex sodium",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "NMS",
"pos": [],
"type": ""
},
"tail": {
"name": "risperidone",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "NMS",
"pos": [],
"type": ""
},
"tail": {
"name": "topiramate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "NMS",
"pos": [],
"type": ""
},
"tail": {
"name": "venlafaxine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "SS",
"pos": [],
"type": ""
},
"tail": {
"name": "carbamazepine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "SS",
"pos": [],
"type": ""
},
"tail": {
"name": "divalproex sodium",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "SS",
"pos": [],
"type": ""
},
"tail": {
"name": "risperidone",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "SS",
"pos": [],
"type": ""
},
"tail": {
"name": "topiramate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "SS",
"pos": [],
"type": ""
},
"tail": {
"name": "venlafaxine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Case report : life - threatening hypoglycaemia associated with sulfadoxine - pyrimethamine , a commonly used antimalarial drug .
|
[
{
"head": {
"name": "life - threatening hypoglycaemia",
"pos": [],
"type": ""
},
"tail": {
"name": "sulfadoxine - pyrimethamine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Fatal radiation myelopathy after high - dose busulfan and melphalan chemotherapy and radiotherapy for Ewing 's sarcoma : a review of the literature and implications for practice .
|
[
{
"head": {
"name": "Fatal radiation myelopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "busulfan",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "Fatal radiation myelopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "melphalan",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Falling backward in two elderly patients taking bupropion .
|
[
{
"head": {
"name": "Falling backward",
"pos": [],
"type": ""
},
"tail": {
"name": "bupropion",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
CASE SUMMARY : A 68-year - old woman developed a dry , irritating cough within one month of starting quinapril therapy for the treatment of essential hypertension .
|
[
{
"head": {
"name": "irritating cough",
"pos": [],
"type": ""
},
"tail": {
"name": "quinapril",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The cases are important in documenting that drug - induced dystonias do occur in patients with dementia , that risperidone appears to have contributed to dystonia among elderly patients , and that the categorization of dystonic reactions needs further clarification .
|
[
{
"head": {
"name": "dystonia",
"pos": [],
"type": ""
},
"tail": {
"name": "risperidone",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
CONCLUSIONS : Symptoms and pathologic changes of colitis are associated with exposure to rofecoxib .
|
[
{
"head": {
"name": "colitis",
"pos": [],
"type": ""
},
"tail": {
"name": "rofecoxib",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
Six of 13 outpatients with schizophrenia who participated in a ten - week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect , including feelings of agitation and depression and periods of crying and insomnia .
|
[
{
"head": {
"name": "depression",
"pos": [],
"type": ""
},
"tail": {
"name": "risperidone",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "feelings of agitation",
"pos": [],
"type": ""
},
"tail": {
"name": "risperidone",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "insomnia",
"pos": [],
"type": ""
},
"tail": {
"name": "risperidone",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "intolerable affect",
"pos": [],
"type": ""
},
"tail": {
"name": "risperidone",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "periods of crying",
"pos": [],
"type": ""
},
"tail": {
"name": "risperidone",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
One patient on ouabain also developed cardiomyopathy .
|
[
{
"head": {
"name": "cardiomyopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "ouabain",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia .
|
[
{
"head": {
"name": "dystonia",
"pos": [],
"type": ""
},
"tail": {
"name": "carbamazepine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We report the first biopsy confirmed occurrence of acute interstitial nephritis in a patient receiving treatment with Sunitinib for metastatic renal cell cancer .
|
[
{
"head": {
"name": "acute interstitial nephritis",
"pos": [],
"type": ""
},
"tail": {
"name": "Sunitinib",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
A case of acute cardiomyopathy and pericarditis associated with methylphenidate .
|
[
{
"head": {
"name": "acute cardiomyopathy",
"pos": [],
"type": ""
},
"tail": {
"name": "methylphenidate",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "pericarditis",
"pos": [],
"type": ""
},
"tail": {
"name": "methylphenidate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
CONCLUSIONS : Clarithromycin may be a cause of fulminant liver failure either alone or by inhibiting the metabolism of other drugs .
|
[
{
"head": {
"name": "fulminant liver failure",
"pos": [],
"type": ""
},
"tail": {
"name": "Clarithromycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
In this report we present four patients treated with a combination of different psychotropic drugs , in whom asterixis was triggered either by adding carbamazepine ( CBZ ) to a treatment regimen , or by increasing its dosage .
|
[
{
"head": {
"name": "asterixis",
"pos": [],
"type": ""
},
"tail": {
"name": "carbamazepine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "asterixis",
"pos": [],
"type": ""
},
"tail": {
"name": "CBZ",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
MTX - induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia , gestational disease and during treatment of psoriasis and rheumatoid arthritis .
|
[
{
"head": {
"name": "hepatic injury",
"pos": [],
"type": ""
},
"tail": {
"name": "MTX",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "liver enzyme elevations",
"pos": [],
"type": ""
},
"tail": {
"name": "MTX",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin , etoposide and bleomycin .
|
[
{
"head": {
"name": "localized pigmentation",
"pos": [],
"type": ""
},
"tail": {
"name": "bleomycin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "localized pigmentation",
"pos": [],
"type": ""
},
"tail": {
"name": "cisplatin",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "localized pigmentation",
"pos": [],
"type": ""
},
"tail": {
"name": "etoposide",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
A patient presented with a painful , oedematous , cyanosed hand having injected a solution of diamorphine and methylphenidate into his radial artery .
|
[
{
"head": {
"name": "painful , oedematous , cyanosed hand",
"pos": [],
"type": ""
},
"tail": {
"name": "diamorphine",
"pos": [],
"type": ""
},
"type": "adverse effect"
},
{
"head": {
"name": "painful , oedematous , cyanosed hand",
"pos": [],
"type": ""
},
"tail": {
"name": "methylphenidate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
This case emphasizes the importance of the evaluation of lithium - associated polyuria with a direct measurement of plasma vasopressin , interpreted with simultaneous plasma and urine osmolality to secure the correct diagnosis and ensure appropriate therapeutic management .
|
[
{
"head": {
"name": "polyuria",
"pos": [],
"type": ""
},
"tail": {
"name": "lithium",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
A 65-year - old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate ( 5 mg ) .
|
[
{
"head": {
"name": "syncope",
"pos": [],
"type": ""
},
"tail": {
"name": "isosorbide dinitrate",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
However , dermatologists should be cautious about a photosensitivity reaction induced by mequitazine or other phenothiazine - derivative drugs .
|
[
{
"head": {
"name": "photosensitivity",
"pos": [],
"type": ""
},
"tail": {
"name": "mequitazine",
"pos": [],
"type": ""
},
"type": "adverse effect"
}
] |
ADE_corpus
|
[
"adverse effect"
] |
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