Datasets:
manufernandezbur
/
tox_nontox_clustered_2025

Dataset card Data Studio Files
xet
Community
1
Unnamed: 0
int64
2
562k
Entry
stringlengths
6
10
Sequence
stringlengths
11
999
Protein names
stringlengths
5
558
Organism
stringclasses
392 values
Organism (ID)
int64
595
2.89M
Length
int64
11
999
Mass
int64
1.06k
118k
Keywords
stringlengths
4
380
⌀
Gene Ontology IDs
stringlengths
10
754
⌀
Protein existence
stringclasses
5 values
Annotation
float64
1
5
Subcellular location [CC]
stringlengths
30
2.26k
⌀
Signal peptide
stringclasses
677 values
Transmembrane
stringlengths
32
2.52k
⌀
Pfam
stringlengths
8
72
⌀
InterPro
stringlengths
10
180
⌀
PDB
stringlengths
5
2.65k
⌀
Taxonomic lineage
stringclasses
178 values
Gene Names
stringlengths
2
299
⌀
Toxin
bool
2 classes
species
stringclasses
111 values
cdhit_cluster
int64
0
4.65k
cdhit_rep
stringlengths
5
10
cdhit_rep_is_ref
bool
1 class
cdhit_pct_id
float64
26,800
P9WHW5
MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITPEEAHSHPQRSLIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVDYDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIVKRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMRGIQGSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGLPAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSAPAPTGTTPAIPTSASPAAPASPPTPWPVTSSPTMAALPPPPPQPGIDCRAAA
Serine/threonine protein phosphatase PstP (EC 3.1.3.16) (Mycobacterial Ser/Thr phosphatase) (Mstp) (PP2C-family Ser/Thr phosphatase)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
514
53,812
3D-structure;Cell membrane;Hydrolase;Manganese;Membrane;Metal-binding;Phosphoprotein;Protein phosphatase;Reference proteome;Transmembrane;Transmembrane helix
GO:0000287; GO:0004721; GO:0004722; GO:0005886; GO:0006355; GO:0007165; GO:0009274; GO:0016020; GO:0030145
Evidence at protein level
5
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
null
TRANSMEM 303..323; /note="Helical"; /evidence="ECO:0000255"
PF13672;
IPR036457;IPR001932;
1TXO;2CM1;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
pstP mstp ppp Rv0018c
false
Mycobacterium tuberculosis
330
row_23446
false
null
190,591
P0A585
MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGHDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP
Glucose-6-phosphate 1-dehydrogenase 2 (G6PD 2) (EC 1.1.1.49)
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
233,413
514
57,343
Carbohydrate metabolism;Glucose metabolism;NADP;Oxidoreductase;Reference proteome
GO:0004345; GO:0005829; GO:0006006; GO:0009051; GO:0050661
Inferred from homology
3
null
null
null
PF02781;PF00479;
IPR001282;IPR019796;IPR022675;IPR022674;IPR036291;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype)
zwf2 zwf BQ2027_MB1482C
false
Mycobacterium tuberculosis
331
row_177436
false
null
212,590
P9WIA8
MSQSHIGGVSRREFLAKVAAGGAGALMSFAGPVIEKAYGAGPCSGHLTDIEHFVFFMQENRSFDHYFGTLSGTDGFNTVSPLFQQKGWNPMTQALDATGVTMPYRFDTTRGPFLDGACVNDPDHSWVAMHESWNGGVNDNWLPAQAKTRSAAHTPTVMGYYTRQDIPIHYLLADAFTVCDRYFCSVLGPTLPNRLYWLSATIDPDGQNGGPELQSPTFQPVRRFGWRIMPQNLSDAGVSWKVYRNKTLGPISSVLTYGSLVTSFKQSADPRSDLVRFGVAPSYPASFAADVLANRLPRVSWVIPNVLESEHPAVPAAAGAFAIVNILRILLANPAVWEKTALIVSYDENGGFFDHVVPATAPAGTPGEYVTVPDIDQVPGSGGIRGPIGLGFRVPCFVISPYSRGPQMVHDTFDHTSQLRLLETRFGVPVPNLTAWRRSVTGDMTSTFNFAVPPNSSWPNLDYPGLHALSTVPQCVPNAALGTINRGIPYRVPDPQIMPTQETTPTRGIPSGPC
Phospholipase C D (PLC-D) (EC 3.1.4.3)
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
514
55,770
Cell wall;Hydrolase;Reference proteome;Secreted;Signal;Virulence
GO:0005576; GO:0034480
Evidence at protein level
3
SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250|UniProtKB:P9WIA9}. Note=Remains associated with the cell. {ECO:0000250|UniProtKB:P9WIA9}.
SIGNAL 1..37; /note="Tat-type signal"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00648"
null
PF04185;
IPR017850;IPR007312;IPR006311;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
plcD MT1799
false
Mycobacterium tuberculosis
332
row_198798
false
null
212,577
P9WI43
MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAEYASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAAAQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNEADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGGAASTVGAVNPWQWLLALLQQLWNAYTGFYGWMLQLIWQFLQDPIGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSPFLLPAGLGLGLAAIAFLPIVLAPAVIPPASTPLAAAAVAAGSVWPAVSMAVTGAGTAGAATPAAGAAPSAGAAPAPAAPATASFAYAVGGSGDWGPSLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRSELRDYGDEFLDMDSDSGFGPSTGDHGAQASERGAGTLGFAGTATKERRVRAVGLTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHDSK
PPE family protein PPE4
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
513
51,788
3D-structure;Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix
GO:0005886; GO:0052572
Evidence at protein level
3
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
null
TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 309..329; /note="Helical"; /evidence="ECO:0000255"
PF00823;PF18878;
IPR043641;IPR000030;IPR038332;
6UUJ;6VHR;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
PPE4 Rv0286
false
Mycobacterium tuberculosis
333
row_198785
false
null
546,882
P9WLH8
MPVEAPRPARHLEVERKFDVIESTVSPSFEGIAAVVRVEQSPTQQLDAVYFDTPSHDLARNQITLRRRTGGADAGWHLKLPAGPDKRTEMRAPLSASGDAVPAELLDVVLAIVRDQPVQPVARISTHRESQILYGAGGDALAEFCNDDVTAWSAGAFHAAGAADNGPAEQQWREWELELVTTDGTADTKLLDRLANRLLDAGAAPAGHGSKLARVLGATSPGELPNGPQPPADPVHRAVSEQVEQLLLWDRAVRADAYDAVHQMRVTTRKIRSLLTDSQESFGLKESAWVIDELRELANVLGVARDAEVLGDRYQRELDALAPELVRGRVRERLVDGARRRYQTGLRRSLIALRSQRYFRLLDALDALVSERAHATSGEESAPVTIDAAYRRVRKAAKAAKTAGDQAGDHHRDEALHLIRKRAKRLRYTAAATGADNVSQEAKVIQTLLGDHQDSVVSREHLIQQAIAANTAGEDTFTYGLLYQQEADLAERCREQLEAALRKLDKAVRKARD
Uncharacterized protein MT2285
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
513
56,332
Reference proteome
null
Predicted
1
null
null
null
PF05235;PF01928;
IPR007899;IPR038186;IPR033469;IPR023577;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
MT2285
false
Mycobacterium tuberculosis
334
row_526974
false
null
544,727
P64954
MPASRLVRQVSAPRNLFGRLVAQGGFYTAGLQLGSGAVVLPVICAHQGLTWAAGLLYPAFCIGAILGNSLSPLILQRAGQLRHLLMAAISATAAALVVCNAAVPWTGVGVAAVFLATTGAGGVVTGVSSVAYTDMISSMLPAVRRGELLLTQGAAGSVLATGVTLVIVPMLAHGNEMARYHDLLWLGAAGLVCSGIAALFVGPMRSVSVTTATRMPLREIYWMGFAIARSQPWFRRYMTTYLLFVPISLGTTFFSLRAAQSNGSLHVLVILSSIGLVVGSMLWRQINRLFGVRGLLLGSALLNAAAALLCMVAESCGQWVHAWAYGTAFLLATVAAQTVVAASISWISVLAPERYRATLICVGSTLAAVEATVLGVALGGIAQKHATIWPVVVVLTLAVIAAVASLRAPTRIGVTADTSPQAATLQAYRPATPNPIHSDERSTPPDHLSVRRGQLRHVWDSRRPAPPLNRPSCRRAARRPAPGKPAAALPQPRHPAVGVREGAPLDAGQRIA
Uncharacterized protein Mb2232
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
233,413
512
53,579
Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix
GO:0005886
Predicted
1
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
null
TRANSMEM 25..45; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 55..75; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 96..116; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 123..143; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 329..349; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 359..379; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255"
null
IPR036259;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype)
BQ2027_MB2232
false
Mycobacterium tuberculosis
335
row_524970
false
null
81,751
P9WIK9
MRIGPVELSAVKDWDPAPGVLVSWHPTPASCAKALAAPVSAVPPSYVQARQIRSFSEQAARGLDHSRLLIASVEVFGHCDLRAMTYVINAHLRRHDTYRSWFELRDTDHIVRHSIADPADIEFVPTTHGEMTSADLRQHIVATPDSLHWDCFSFGVIQRADSFTFYASIDHLHADGQFVGVGLMEFQSMYTALIMGEPPIGLSEAGSYVDFCVRQHEYTSALTVDSPEVRAWIDFAEINNGTFPEFPLPLGDPSVRCGGDLLSMMLMDEQQTQRFESACMAANARFIGGMLACIAIAIHELTGADTYFGITPKDIRTPADLMTQGWFTGQIPVTVPVAGLSFNEIARIAQTSFDTGADLAKVPFERVVELSPSLRRPQPLFSLVNFFDAQVGPLSAVTKLFEGLNVGTYSDGRVTYPLSTMVGRFDETAASVLFPDNPVARESVTAYLRAIRSVCMRIANGGTAERVGNVVALSPGRRNNIERMTWRSCRAGDFIDICNLKVANVTVDREA
2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase PapA1 (EC 2.3.1.283) (Polyketide synthase-associated protein A1) (SL659 acyltransferase PapA1)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
511
56,128
Acyltransferase;Cell wall biogenesis/degradation;Lipid biosynthesis;Lipid metabolism;Reference proteome;Transferase
GO:0016747; GO:0046506; GO:0071555
Evidence at protein level
4
null
null
null
PF00668;
IPR023213;IPR001242;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
papA1 Rv3824c
false
Mycobacterium tuberculosis
336
row_72198
false
null
81,879
P9WNQ7
MSAPAVAAGPTAAGATAARPATTRVTILTGRRMTDLVLPAAVPMETYIDDTVAVLSEVLEDTPADVLGGFDFTAQGVWAFARPGSPPLKLDQSLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRTALNRFVGAAIPLLTAPVIGMAMRAWWETGRSLWWPLAIGILGIAVLVGSFVANRFYQSGHLAECLLVTTYLLIATAAALAVPLPRGVNSLGAPQVAGAATAVLFLTLMTRGGPRKRHELASFAVITAIAVIAAAAAFGYGYQDWVPAGGIAFGLFIVTNAAKLTVAVARIALPPIPVPGETVDNEELLDPVATPEATSEETPTWQAIIASVPASAVRLTERSKLAKQLLIGYVTSGTLILAAGAIAVVVRGHFFVHSLVVAGLITTVCGFRSRLYAERWCAWALLAATVAIPTGLTAKLIIWYPHYAWLLLSVYLTVALVALVVVGSMAHVRRVSPVVKRTLELIDGAMIAAIIPMLLWITGVYDTVRNIRF
ESX-1 secretion system protein EccD1 (ESX conserved component D1) (Snm4 secretory protein) (Type VII secretion system protein EccD1) (T7SS protein EccD1)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
511
53,999
3D-structure;Acetylation;Cell inner membrane;Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix;Transport
GO:0005886; GO:0009274; GO:0042783; GO:0051701
Evidence at protein level
4
SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
null
TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 171..191; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 228..248; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 286..306; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 368..388; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 389..409; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 421..441; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 445..465; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 483..503; /note="Helical"; /evidence="ECO:0000255"
PF08817;
IPR006707;IPR024962;
4KV2;4KV3;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
eccD1 snm4 Rv3877
false
Mycobacterium tuberculosis
337
row_72320
false
null
190,611
P0A5L5
MIELTVAQIAEIVGGAVADISPQDAAHRRVTGTVEFDSRAIGPGGLFLALPGARADGHDHAASAVAAGAAVVLAARPVGVPAIVVPPVAAPNVLAGVLEHDNDGSGAAVLAALAKLATAVAAQLVAGGLTIIGITGSSGKTSTKDLMAAVLAPLGEVVAPPGSFNNELGHPWTVLRATRRTDYLILEMAARHHGNIAALAEIAPPSIGVVLNVGTAHLGEFGSREVIAQTKAELPQAVPHSGAVVLNADDPAVAAMAKLTAARVVRVSRDNTGDVWAGPVSLDELARPRFTLHAHDAQAEVRLGVCGDHQVTNALCAAAVALECGASVEQVAAALTAAPPVSRHRMQVTTRGDGVTVIDDAYNANPDSMRAGLQALAWIAHQPEATRRSWAVLGEMAELGEDAIAEHDRIGRLAVRLDVSRLVVVGTGRSISAMHHGAVLEGAWGSGEATADHGADRTAVNVADGDAALALLRAELRPGDVVLVKASNAAGLGAVADALVADDTCGSVRP
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (EC 6.3.2.10) (D-alanyl-D-alanine-adding enzyme) (UDP-MurNAc-pentapeptide synthetase)
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
233,413
510
51,633
ATP-binding;Cell cycle;Cell division;Cell shape;Cell wall biogenesis/degradation;Cytoplasm;Ligase;Nucleotide-binding;Peptidoglycan synthesis;Reference proteome
GO:0005524; GO:0005737; GO:0008360; GO:0008766; GO:0009252; GO:0047480; GO:0051301; GO:0071555
Inferred from homology
3
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02019}.
null
null
PF01225;PF02875;PF08245;
IPR036565;IPR004101;IPR036615;IPR013221;IPR000713;IPR051046;IPR035911;IPR005863;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype)
murF BQ2027_MB2181C
false
Mycobacterium tuberculosis
338
row_177456
false
null
26,379
P96368
MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVLSLSGYVTAMNDAELVESLHALNHSYTRYRDSAQTSTPTGNLPMSQAVLEFTGQTPGNLIAVLHDGVVIGSAVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSSAAGADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYALRPLRRVAATAAEVATMPLTDDDHQISVRVRPGDTDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDLRMRQFITDASHELRTPLAAIQGYAELTRQDSSDLPPTTEYALARIESEARRMTLLVDELLLLSRLSEGEDLETEDLDLTDLVINAVNDAAVAAPTHRWVKNLPDEPVWVNGDHARLHQLVSNLLTNAWVHTQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDIDPEILPHLFDRFVRASKSRSNGSGHGLGLAIVSSIVKAHRGSVTAESGNGQTVFRVRLPMIEQQIATTA
Sensor histidine kinase TrcS (EC 2.7.13.3) (Tuberculosis regulatory component sensor)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
509
54,591
ATP-binding;Calcium;Cell membrane;Kinase;Manganese;Membrane;Nucleotide-binding;Phosphoprotein;Reference proteome;Transferase;Transmembrane;Transmembrane helix;Two-component regulatory system
GO:0000155; GO:0000160; GO:0004672; GO:0005509; GO:0005524; GO:0005886; GO:0030145
Evidence at protein level
5
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
null
TRANSMEM 24..44; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 188..208; /note="Helical"; /evidence="ECO:0000255"
PF02518;PF00512;
IPR003660;IPR036890;IPR005467;IPR003661;IPR036097;IPR004358;IPR050428;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
trcS Rv1032c
false
Mycobacterium tuberculosis
339
row_23091
false
null
212,944
P9WN61
MTVAAGAAKAAGAELLDYDEVVARFQPVLGLEVHVELSTATKMFCGCTTTFGGEPNTQVCPVCLGLPGSLPVLNRAAVESAIRIGLALNCEIVPWCRFARKNYFYPDMPKNYQISQYDEPIAINGYLDAPLEDGTTWRVEIERAHMEEDTGKLTHIGSETGRIHGATGSLIDYNRAGVPLIEIVTKPIVGAGARAPQIARSYVTALRDLLRALDVSDVRMDQGSMRCDANVSLKPAGTTEFGTRTETKNVNSLKSVEVAVRYEMQRQGAILASGGRITQETRHFHEAGYTSAGRTKETAEDYRYFPEPDLEPVAPSRELVERLRQTIPELPWLSRRRIQQEWGVSDEVMRDLVNAGAVELVAATVEHGASSEAARAWWGNFLAQKANEAGIGLDELAITPAQVAAVVALVDEGKLSNSLARQVVEGVLAGEGEPEQVMTARGLALVRDDSLTQAAVDEALAANPDVADKIRGGKVAAAGAIVGAVMKATRGQADAARVRELVLEACGQG
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (Asp/Glu-ADT subunit B) (EC 6.3.5.-)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
509
54,633
ATP-binding;Ligase;Nucleotide-binding;Protein biosynthesis;Reference proteome
GO:0005524; GO:0005886; GO:0006412; GO:0050566; GO:0050567; GO:0070681
Evidence at protein level
3
null
null
null
PF02934;PF02637;
IPR017959;IPR006075;IPR018027;IPR003789;IPR004413;IPR023168;IPR017958;IPR014746;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
gatB Rv3009c MTV012.23c
false
Mycobacterium tuberculosis
340
row_199146
false
null
432,046
P9WNQ4
MTAPHKVAFPARCAVNICYDKHLCSQVFPAGIPVEGFFEGMVELFDADLKRKGFDGVALPAGSYELHKINGVRLDINKSLDELGVQDGNTLVLVPRVAGESFEPQYESLSTGLAAMGKWLGRDGGDRMFAPVTSLTAAHTAMAIIAMAVGVVLALTLRTRTITDSPVPAAMAGGIGVLLVIGALVVWWGWRERRDLFSGFGWLAVVLLAVAAACAPPGALGAAHALIGLVVVVLGAITIGVATRKRWQTAVVTAVVTVCGILAAVAAVRMFRPVSMQVLAICVLVGLLVLIRMTPTVALWVARVRPPHFGSITGRDLFARRAGMPVDTVAPVSEADADDEDNELTDITARGTAIAASARLVNAVQVGMCVGVSLVLPAAVWGVLTPRQPWAWLALLVAGLTVGLFITQGRGFAAKYQAVALVCGASAAVCAGVLKYALDTPKGVQTGLLWPAIFVAAFAALGLAVALVVPATRFRPIIRLTVEWLEVLAMIALLPAAAALGGLFAWLRH
ESX-2 secretion system protein eccD2 (ESX conserved component D2) (Type VII secretion system protein eccD2) (T7SS protein eccD2)
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
509
53,277
Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix
GO:0005886
Inferred from homology
2
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
null
TRANSMEM 135..155; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 222..242; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 281..301; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 364..384; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 389..409; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 418..438; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 449..469; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 487..507; /note="Helical"; /evidence="ECO:0000255"
PF19053;PF08817;
IPR044049;IPR006707;IPR024962;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
eccD2 MT4002
false
Mycobacterium tuberculosis
341
row_413793
false
null
208,068
P66878
MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSVDSQDRVFTPRRYPEAGRATATKSSRHSD
Cobalamin biosynthesis protein CobIJ [Includes: Precorrin-2 C(20)-methyltransferase (EC 2.1.1.130) (S-adenosyl-L-methionine--precorrin-2 methyltransferase) (SP2MT); Precorrin-3B C17-methyltransferase (EC 2.1.1.131) (S-adenosyl-L-methionine--precorrin-3B methyltransferase)]
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
233,413
508
53,911
Cobalamin biosynthesis;Methyltransferase;Multifunctional enzyme;Reference proteome;S-adenosyl-L-methionine;Transferase
GO:0009236; GO:0030788; GO:0030789; GO:0032259
Inferred from homology
3
null
null
null
PF00590;
IPR000878;IPR035996;IPR014777;IPR014776;IPR006363;IPR012382;IPR006364;IPR051810;IPR003043;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype)
cobIJ cobI BQ2027_MB2092
false
Mycobacterium tuberculosis
342
row_194490
false
null
212,751
P9WJW9
MTPRQRLTVLATGLGIFMVFVDVNIVNVALPSIQKVFHTGEQGLQWAVAGYSLGMAAVLMSCALLGDRYGRRRSFVFGVTLFVVSSIVCVLPVSLAVFTVARVIQGLGAAFISVLSLALLSHSFPNPRMKARAISNWMAIGMVGAASAPALGGLMVDGLGWRSVFLVNVPLGAIVWLLTLVGVDESQDPEPTQLDWVGQLTLIPAVALIAYTIIEAPRFDRQSAGFVAALLLAAGVLLWLFVRHEHRAAFPLVDLKLFAEPLYRSVLIVYFVVMSCFFGTLMVITQHFQNVRDLSPLHAGLMMLPVPAGFGVASLLAGRAVNKWGPQLPVLTCLAAMFIGLAIFAISMDHAHPVALVGLTIFGAGAGGCATPLLHLGMTKVDDGRAGMAAGMLNLQRSLGGIFGVAFLGTIVAAWLGAALPNTMADEIPDPIARAIVVDVIVDSANPHAHAAFIGPGHRITAAQEDEIVLAADAVFVSGIKLALGGAAVLLTGAFVLGWTRFPRTPAS
Drug efflux pump JefA
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
508
53,479
Antibiotic resistance;Cell inner membrane;Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix;Transport
GO:0005886; GO:0016020; GO:0022857; GO:0046677
Evidence at transcript level
3
SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
null
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 46..66; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 194..214; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 222..242; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 297..317; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 354..374; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 399..419; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 479..499; /note="Helical"; /evidence="ECO:0000255"
PF07690;
IPR011701;IPR020846;IPR036259;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
jefA Rv2459
false
Mycobacterium tuberculosis
343
row_198955
false
null
26,988
P9WNV5
MLLHDVAITSMDVAATSSRLTKVARIAALLHRAAPDTQLVTIIVSWLSGELPQRHIGVGWAALRSLPPPAPQPALTVTGVDATLSKIGTLPGKGSQAQRAALVAELFSAATEAEQTFLLRLLGGELRQGAKGGIMADAVAQAAGLPAATVQRAAMLGGDLAAAAAAGLSGAALDTFTLRVGRPIGPMLAQTATSVHDALERHGGTTIFEAKLDGARVQIHRANDQVRIYTRSLDDVTARLPEVVEATLALPVRDLVADGEAIALCPDNRPQRFQVTASRFGRSVDVAAARATQPLSVFFFDILHRDGTDLLEAPTTERLAALDALVPARHRVDRLITSDPTDAANFLDATLAAGHEGVMAKAPAARYLAGRRGAGWLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIHLGARDPATGGFVMVGKTFKGMTDAMLDWQTTRFHEIAVGPTDGYVVQLRPEQVVEVALDGVQRSSRYPGGLALRFARVVRYRADKDPAEADTIDAVRALY
DNA ligase B (LigB) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
507
53,737
ATP-binding;Cell cycle;Cell division;DNA damage;DNA recombination;DNA repair;DNA replication;Ligase;Magnesium;Metal-binding;Nucleotide-binding;Reference proteome
GO:0000287; GO:0003677; GO:0003910; GO:0005524; GO:0006260; GO:0006281; GO:0006310; GO:0009274; GO:0051301; GO:0071897
Evidence at protein level
5
null
null
null
PF04679;PF01068;PF04675;
IPR050191;IPR022865;IPR000977;IPR012309;IPR012310;IPR016059;IPR012308;IPR036599;IPR012340;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
ligB Rv3062
false
Mycobacterium tuberculosis
344
row_23627
false
null
26,989
P9WNW3
MTDDPGSGFTTVWNAVVSELNGDPKVDDGPSSDANLSAPLTPQQRAWLNLVQPLTIVEGFALLSVPSSFVQNEIERHLRAPITDALSRRLGHQIQLGVRIAPPATDEADDTTVPPSENPATTSPDTTTDNDEIDDSAAARGDNQHSWPSYFTERPHNTDSATAGVTSLNRRYTFDTFVIGASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLLHAAGNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFIEGKEGIQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPELETRIAILRKKAQMERLAVPDDVLELIASSIERNIRELEGALIRVTAFASLNKTPIDKALAEIVLRDLIADANTMQISAATIMAATAEYFDTTVEELRGPGKTRALAQSRQIAMYLCRELTDLSLPKIGQAFGRDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQRSKR
Chromosomal replication initiator protein DnaA (EC 3.6.4.-)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
507
56,567
3D-structure;ATP-binding;Cell membrane;Cell wall;Cytoplasm;DNA replication;DNA-binding;Hydrolase;Lipid-binding;Membrane;Nucleotide-binding;Reference proteome;Secreted
GO:0003688; GO:0005524; GO:0005576; GO:0005737; GO:0005886; GO:0006260; GO:0006270; GO:0006275; GO:0008289; GO:0009274; GO:0016887
Evidence at protein level
5
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}. Cell membrane {ECO:0000269|PubMed:18296714}. Secreted, cell wall {ECO:0000269|PubMed:18296714}. Note=Very little protein is found in soluble extracts (PubMed:18296714). Nucleoid-associated protein is probably also in the cell membrane fraction (Probable). {ECO:0000269|PubMed:18296714, ECO:0000305}.
null
null
PF00308;PF08299;
IPR003593;IPR001957;IPR020591;IPR018312;IPR013159;IPR013317;IPR038454;IPR027417;IPR010921;
3PVP;3PVV;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
dnaA Rv0001 MTV029.01
false
Mycobacterium tuberculosis
345
row_23628
false
null
212,001
P96843
MINDLRTVPAALDRLVRQLPDHTALIAEDRRFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGALDAVAARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFGYKAGILACLQTGATLIPHVTFDPLHALRAIERHRITVLPGPPTIYQSLLDHPARKDFDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRPEDDAVTVATTCGRPFADFELRIADDGEVLLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGNLRITDRLKDMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVVARPGTGLDEASVIAYTREHLANFKTPRSVRFVDVLPRNAAGKVSKPQLRELG
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase (HIP:CoA ligase) (EC 6.2.1.41)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
507
54,095
ATP-binding;Cholesterol metabolism;Ligase;Lipid metabolism;Nucleotide-binding;Reference proteome;Steroid metabolism;Sterol metabolism
GO:0005524; GO:0008203; GO:0016405
Evidence at protein level
3
null
null
null
PF00501;PF13193;
IPR025110;IPR045851;IPR020845;IPR000873;IPR042099;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
fadD3 Rv3561 P425_03703 RVBD_3561
false
Mycobacterium tuberculosis
346
row_198235
false
null
425,486
P63938
MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPVTGQPFCEVPRSDAADIDKALDAAHAAAPGWGKTAPAERAAILNMIADRIDKNAAALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGALSQIDEDTVAYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVLKPAEQTPASVLYLMSLIGDLLPPGVVNVVNGFGAEAGKPLASSDRIAKVAFTGETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAHDDFCDKALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQGDPLDTETMLGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYMQPTIFTGTNNMRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGVWSRDGNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGREGHQMMLQHYQHTKNLLVSYSDKALGFF
Probable aldehyde dehydrogenase (EC 1.2.1.3)
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
233,413
507
54,575
NAD;Oxidoreductase;Reference proteome
GO:0004029
Inferred from homology
2
null
null
null
PF00171;
IPR016161;IPR016163;IPR016160;IPR029510;IPR016162;IPR015590;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype)
BQ2027_MB0467
false
Mycobacterium tuberculosis
347
row_407587
false
null
213,005
P9WNQ8
MAEESRGQRGSGYGLGLSTRTQVTGYQFLARRTAMALTRWRVRMEIEPGRRQTLAVVASVSAALVICLGALLWSFISPSGQLNESPIIADRDSGALYVRVGDRLYPALNLASARLITGRPDNPHLVRSSQIATMPRGPLVGIPGAPSSFSPKSPPASSWLVCDTVATSSSIGSLQGVTVTVIDGTPDLTGHRQILSGSDAVVLRYGGDAWVIREGRRSRIEPTNRAVLLPLGLTPEQVSQARPMSRALFDALPVGPELLVPEVPNAGGPATFPGAPGPIGTVIVTPQISGPQQYSLVLGDGVQTLPPLVAQILQNAGSAGNTKPLTVEPSTLAKMPVVNRLDLSAYPDNPLEVVDIREHPSTCWWWERTAGENRARVRVVSGPTIPVAATEMNKVVSLVKADTSGRQADQVYFGPDHANFVAVTGNNPGAQTSESLWWVTDAGARFGVEDSKEARDALGLTLTPSLAPWVALRLLPQGPTLSRADALVEHDTLPMDMTPAELVVPK
ESX-5 secretion system ATPase EccB5 (EC 3.6.-.-) (ESX conserved component B5) (Type VII secretion system protein EccB5) (T7SS protein EccB5)
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
506
53,721
ATP-binding;Cell inner membrane;Cell membrane;Hydrolase;Membrane;Nucleotide-binding;Reference proteome;Transmembrane;Transmembrane helix;Transport
GO:0005524; GO:0005576; GO:0005886; GO:0016787
Inferred from homology
3
SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:B2HST3}; Single-pass membrane protein {ECO:0000255}.
null
TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255"
PF05108;
IPR007795;IPR044857;IPR042485;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
eccB5 MT1832
false
Mycobacterium tuberculosis
348
row_199206
false
null
26,985
P9WNU9
MQRIIGTEVEYGISSPSDPTANPILTSTQAVLAYAAAAGIQRAKRTRWDYEVESPLRDARGFDLSRSAGPPPVVDADEVGAANMILTNGARLYVDHAHPEYSAPECTDPLDAVIWDKAGERVMEAAARHVASVPGAAKLQLYKNNVDGKGASYGSHENYLMSRQTPFSAIITGLTPFLVSRQVVTGSGRVGIGPSGDEPGFQLSQRSDYIEVEVGLETTLKRGIINTRDEPHADADRYRRLHVIIGDANLAETSTYLKLGTTALVLDLIEEGPAHAIDLTDLALARPVHAVHAISRDPSLRATVALADGRELTGLALQRIYLDRVAKLVDSRDPDPRAADIVETWAHVLDQLERDPMDCAELLDWPAKLRLLDGFRQRENLSWSAPRLHLVDLQYSDVRLDKGLYNRLVARGSMKRLVTEHQVLSAVENPPTDTRAYFRGECLRRFGADIAAASWDSVIFDLGGDSLVRIPTLEPLRGSKAHVGALLDSVDSAVELVEQLTAEPR
Pup deamidase/depupylase (EC 3.4.-.-) (EC 3.5.1.119) (Deamidase of protein Pup)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
505
55,179
3D-structure;ATP-binding;Hydrolase;Magnesium;Metal-binding;Nucleotide-binding;Reference proteome;Virulence
GO:0005524; GO:0008233; GO:0010498; GO:0016811; GO:0019941; GO:0046872; GO:0070490
Evidence at protein level
5
null
null
null
PF03136;
IPR022366;IPR004347;
9CKU;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
dop pafD Rv2112c
false
Mycobacterium tuberculosis
349
row_23624
false
null
112,282
A1KPT4
MSAADTAEDLPEQFRIRRDKRARLLAQGRDPYPVAVPRTHTLAEVRAAHPDLPIDTATEDIVGVAGRVIFARNSGKLCFATLQDGDGTQLQVMISLDKVGQAALDAWKADVDLGDIVYVHGAVISSRRGELSVLADCWRIAAKSLRPLPVAHKEMSEESRVRQRYVDLIVRPEARAVARLRIAVVRAIRTALQRRGFLEVETPVLQTLAGGAAARPFATHSNALDIDLYLRIAPELFLKRCIVGGFDKVFELNRVFRNEGADSTHSPEFSMLETYQTYGTYDDSAVVTRELIQEVADEAIGTRQLPLPDGSVYDIDGEWATIQMYPSLSVALGEEITPQTTVDRLRGIADSLGLEKDPAIHDNRGFGHGKLIEELWERTVGKSLSAPTFVKDFPVQTTPLTRQHRSIPGVTEKWDLYLRGIELATGYSELSDPVVQRERFADQARAAAAGDDEAMVLDEDFLAALEYGMPPCTGTGMGIDRLLMSLTGLSIRETVLFPIVRPHSN
Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
410,289
505
55,709
Aminoacyl-tRNA synthetase;ATP-binding;Cytoplasm;Ligase;Magnesium;Metal-binding;Nucleotide-binding;Protein biosynthesis
GO:0000049; GO:0000287; GO:0004824; GO:0005524; GO:0005829; GO:0006430
Inferred from homology
3
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00252}.
null
null
PF00152;PF01336;
IPR004364;IPR006195;IPR045864;IPR002313;IPR044136;IPR018149;IPR012340;IPR004365;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype), Mycobacterium tuberculosis variant bovis BCG (no rank)
lysS BCG_3663c
false
Mycobacterium tuberculosis
350
row_100747
false
null
212,786
P9WKA2
MRQQQEADVVALGRKPGLLCVPERFRAMDLPMAAADALFLWAETPTRPLHVGALAVLSQPDNGTGRYLRKVFSAAVARQQVAPWWRRRPHRSLTSLGQWSWRTETEVDLDYHVRLSALPPRAGTAELWALVSELHAGMLDRSRPLWQVDLIEGLPGGRCAVYVKVHHALADGVSVMRLLQRIVTADPHQRQMPTLWEVPAQASVAKHTAPRGSSRPLTLAKGVLGQARGVPGMVRVVADTTWRAAQCRSGPLTLAAPHTPLNEPIAGARSVAGCSFPIERLRQVAEHADATINDVVLAMCGGALRAYLISRGALPGAPLIAMVPVSLRDTAVIDVFGQGPGNKIGTLMCSLATHLASPVERLSAIRASMRDGKAAIAGRSRNQALAMSALGAAPLALAMALGRVPAPLRPPNVTISNVPGPQGALYWNGARLDALYLLSAPVDGAALNITCSGTNEQITFGLTGCRRAVPALSILTDQLAHELELLVGVSEAGPGTRLRRIAGRR
Putative diacyglycerol O-acyltransferase MT0919 (EC 2.3.1.20) (Putative triacylglycerol synthase MT0919)
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
505
53,873
Acyltransferase;Glycerol metabolism;Lipid biosynthesis;Lipid metabolism;Reference proteome;Transferase
GO:0001666; GO:0004144; GO:0005886; GO:0006071; GO:0019432; GO:0051701; GO:0071731
Inferred from homology
3
null
null
null
PF06974;PF03007;
IPR014292;IPR023213;IPR045034;IPR009721;IPR004255;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
MT0919
false
Mycobacterium tuberculosis
351
row_198990
false
null
26,751
P9WGL1
MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIRGELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMNKLRWVLLIVGGIGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVGDLVDLSRGDAGEVVHEPVDMADVVDRSLERVRRRRNDILFDVEVIGWQVYGDTAGLSRMALNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGIPVQERRLVFERFYRSASARALPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGARSTDIENSRGSANVISVESQSTRAT
Signal transduction histidine-protein kinase/phosphatase MprB (EC 2.7.13.3) (EC 3.1.3.-) (Mycobacterial persistence regulator B)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
504
54,408
ATP-binding;Cell membrane;Hydrolase;Kinase;Magnesium;Manganese;Membrane;Nucleotide-binding;Phosphoprotein;Protein phosphatase;Reference proteome;Stress response;Transferase;Transmembrane;Transmembrane helix;Two-component regulatory system;Virulence
GO:0000155; GO:0000160; GO:0004721; GO:0005524; GO:0005576; GO:0005886
Evidence at protein level
5
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
null
TRANSMEM 27..47; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255"
PF00672;PF02518;PF00512;
IPR050980;IPR003660;IPR036890;IPR005467;IPR003661;IPR036097;IPR004358;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
mprB Rv0982
false
Mycobacterium tuberculosis
352
row_23398
false
null
67,564
I6WZK7
MPELATSGNAFDKRRFSRRGFLGAGIASGFALAACASKPTASGAAGMTAAIDAAEAARPHSGRTVTATLTPQPARIDLGGPIVSTLTYGNTIPGPLIRATVGDEIVVSVTNRLGDPTSVHWHGIALRNDMDGTEPATANIGPGGDFTYRFSVPDPGTYWAHPHVGLQGDHGLYLPVVVDDPTEPGHYDAEWIIILDDWTDGIGKSPQQLYGELTDPNKPTMQNTTGMPEGEGVDSNLLGGDGGDIAYPYYLINGRIPVAATSFKAKPGQRIRIRIINSAADTAFRIALAGHSMTVTHTDGYPVIPTEVDALLIGMAERYDVMVTAAGGVFPLVALAEGKNALARALLSTGAGSPPDPQFRPDELNWRVGTVEMFTAATTANLGRPEPTHDLPVTLGGTMAKYDWTINGEPYSTTNPLHVRLGQRPTLMFDNTTMMYHPIHLHGHTFQMIKADGSPGARKDTVIVLPKQKMRAVLVADNPGVWVMHCHNNYHQVAGMATRLDYIL
Multicopper oxidase MmcO (EC 1.16.3.1) (Mycobacterium multicopper oxidase)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
504
53,796
Cell inner membrane;Cell membrane;Copper;Membrane;Metal-binding;Oxidoreductase;Periplasm;Reference proteome;Signal
GO:0004322; GO:0005507; GO:0005886; GO:0042597
Evidence at protein level
4
SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:23772064}; Peripheral membrane protein {ECO:0000269|PubMed:23772064}; Periplasmic side {ECO:0000269|PubMed:23772064}. Periplasm {ECO:0000269|PubMed:23772064}. Note=Could be associated with the membrane through a lipidation site. {ECO:0000269|PubMed:23772064}.
SIGNAL 1..44; /note="Tat-type signal"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00648"
null
PF00394;PF07731;PF07732;
IPR011707;IPR001117;IPR011706;IPR045087;IPR033138;IPR002355;IPR008972;IPR034279;IPR006311;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
mmcO Rv0846c RVBD_0846c P425_00886
false
Mycobacterium tuberculosis
353
row_58696
false
null
181,885
L7N680
MSFVVTVPEAVAAAAGDLAAIGSTLREATAAAAGPTTGLAAAAADDVSIAVSQLFGRYGQEFQTVSNQLAAFHTEFVRTLNRGAAAYLNTESANGGQLFGQIEAGQRAVSAAAAAAPGGAYGQLVANTATNLESLYGAWSANPFPFLRQIIANQQVYWQQIAAALANAVQNFPALVANLPAAIDAAVQQFLAFNAAYYIQQIISSQIGFAQLFATTVGQGVTSVIAGWPNLAAELQLAFQQLLVGDYNAAVANLGKAMTNLLVTGFDTSDVTIGTMGTTISVTAKPKLLGPLGDLFTIMTIPAQEAQYFTNLMPPSILRDMSQNFTNVLTTLSNPNIQAVASFDIATTAGTLSTFFGVPLVLTYATLGAPFASLNAIATSAETIEQALLAGNYLGAVGALIDAPAHALDGFLNSATVLDTPILVPTGLPSPLPPTVGITLHLPFDGILVPPHPVTATISFPGAPVPIPGFPTTVTVFGTPFMGMAPLLINYIPQQLALAIKPAA
PE-PGRS family protein PE_PGRS62
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
504
51,821
Cell wall;Reference proteome;Secreted;Virulence
GO:0005576; GO:0141158
Evidence at protein level
3
SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000269|PubMed:23167250}.
null
null
PF00934;
IPR000084;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
PE_PGRS62 Rv3812
false
Mycobacterium tuberculosis
354
row_168922
false
null
431,867
P9WM60
MTPVTTFPLVDAILAGRDRNLDGVILIAAQHLLQTTHAMLRSLFRVGLDPRNVAVIGKCYSTHPGVVDAMRADGIYVDDCSDAYAPHESFDTQYTRHVERFFAESWARLTAGRTARVVLLDDGGSLLAVAGAMLDASADVIGIEQTSAGYAKIVGCALGFPVINIARSSAKLLYESPIIAARVTQTAFERTAGIDSSAAILITGAGAIGTALADVLRPLHDRVDVYDTRSGCMTPIDLPNAIGGYDVIIGATGATSVPASMHELLRPGVLLMSASSSDREFDAVALRRRTTPNPDCHADLRVADGSVDATLLNSGFPVNFDGSPMCGDASMALTMALLAAAVLYASVAVADEMSSDHPHLGLIDQGDIVASFLNIDVPLQALSRLPLLSIDGYRRLQVRSGYTLFRQGERADHFFVIESGELEALVDGKVILRLGAGDHFGEACLLGGMRRIATVRACEPSVLWELDGKAFGDALHGDAAMREIAYGVARTRLMHAGASESLMV
Uncharacterized protein MT0113
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
504
53,451
Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix
GO:0003700; GO:0005829; GO:0005886
Predicted
2
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
null
TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 330..350; /note="Helical"; /evidence="ECO:0000255"
PF00027;
IPR042172;IPR000595;IPR018490;IPR050397;IPR036291;IPR014710;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
MT0113
false
Mycobacterium tuberculosis
355
row_413622
false
null
27,048
P9WQ37
MKNIGWMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKGDRVALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYGAPSAPVIDAIRAQADPPGTVTDWIGADSLAERLRSAAADEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWASTIDVRYRDRLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEERVCIGGAVPAILNFMRQVPEFAELDAPDFRYFITGGAPMPEALIKIYAAKNIEVVQGYALTESCGGGTLLLSEDALRKAGSAGRATMFTDVAVRGDDGVIREHGEGEVVIKSDILLKEYWNRPEATRDAFDNGWFRTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGLPDEKWGEIAAAIVVADQNEVSEQQIVEYCGTRLARYKLPKKVIFAEAIPRNPTGKILKTVLREQYSATVPK
Long-chain-fatty-acid--CoA ligase FadD13 (EC 6.2.1.3) (Fatty acyl-CoA ligase) (FACL) (FACL13) (Fatty acyl-CoA synthetase) (ACS) (FACS) (Very-long-chain fatty-acyl-CoA synthetase) (ACSVL)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
503
54,459
3D-structure;ATP-binding;Cell membrane;Fatty acid metabolism;Ligase;Lipid metabolism;Membrane;Nucleotide-binding;Reference proteome
GO:0004321; GO:0004467; GO:0005524; GO:0005829; GO:0005886; GO:0006633; GO:0009274; GO:0010447; GO:0016405; GO:0051701
Evidence at protein level
5
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22560731}; Peripheral membrane protein {ECO:0000269|PubMed:22560731}. Note=Membrane-associated through distinctive regions rich in arginine and aromatic residues. {ECO:0000269|PubMed:22560731}.
null
null
PF00501;PF13193;
IPR025110;IPR045851;IPR020845;IPR000873;IPR042099;
3R44;3T5B;3T5C;5ZRN;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
fadD13 Rv3089
false
Mycobacterium tuberculosis
356
row_23687
false
null
213,003
P9WNP9
MTAVADAPQADIEGVASPQAVVVGVMAGEGVQIGVLLDANAPVSVMTDPLLKVVNSRLRELGEAPLEATGRGRWALCLVDGAPLRATQSLTEQDVYDGDRLWIRFIADTERRSQVIEHISTAVASDLSKRFARIDPIVAVQVGASMVATGVVLATGVLGWWRWHHNTWLTTIYTAVIGVLVLAVAMLLLMRAKTDADRRVADIMLMSAIMPVTVAAAAAPPGPVGSPQAVLGFGVLTVAAALALRFTGRRLGIYTTIVIIGALTMLAALARMVAATSAVTLLSSLLLICVVAYHAAPALSRRLAGIRLPVFPSATSRWVFEARPDLPTTVVVSGGSAPVLEGPSSVRDVLLQAERARSFLSGLLTGLGVMVVVCMTSLCDPHTGQRWLPLILAGFTSGFLLLRGRSYVDRWQSITLAGTAVIIAAAVCVRYALELSSPLAVSIVAAILVLLPAAGMAAAAHVPHTIYSPLFRKFVEWIEYLCLMPIFPLALWLMNVYAAIRYR
ESX-5 secretion system protein EccD5 (ESX conserved component D5) (Type VII secretion system protein EccD5) (T7SS protein EccD5)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
503
53,435
3D-structure;Cell inner membrane;Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix;Transport
GO:0005886
Evidence at protein level
3
SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:B2HSU6}; Multi-pass membrane protein {ECO:0000255}.
null
TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 200..220; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 272..292; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 359..379; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 382..402; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 439..459; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 480..500; /note="Helical"; /evidence="ECO:0000255"
PF19053;PF08817;
IPR044049;IPR006707;IPR024962;
7NP7;7NPR;7NPT;7NPU;7NPV;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
eccD5 Rv1795
false
Mycobacterium tuberculosis
357
row_199204
false
null
545,041
P68908
MALGRAFSVAVRGLDGEIVEIEADITSGLPGVHLVGLPDAALQESRDRVRAAVTNCGNSWPMARLTLALSPATLPKMGSVYDIALAAAVLSAQQKKPWERLENTLLLGELSLDGRVRPVRGVLPAVLAAKRDGWPAVVVPADNLPEASLVDGIDVRGVRTLGQLQSWLRGSTGLAGRITTADTTPESAADLADVVGQSQARFAVEVAAAGAHHLMLTGPPGVGKTMLAQRLPGLLPSLSGSESLEVTAIHSVAGLLSGDTPLITRPPFVAPHHSSSVAALVGGGSGMARPGAVSRAHRGVLFLDECAEISLSALEALRTPLEDGEIRLARRDGVACYPARFQLVLAANPCPCAPADPQDCICAAATKRRYLGKLSGPLLDRVDLRVQMHRLRAGAFSAADGESTSQVRQRVALAREAAAQRWRPHGFRTNAEVSGPLLRRKFRPSSAAMLPLRTALDRGLLSIRGVDRTLRVAWSLADLAGRTSPGIDEVAAALSFRQTGARR
Uncharacterized protein Mb2921c
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
233,413
503
52,913
Reference proteome
GO:0005524; GO:0016887
Inferred from homology
1
null
null
null
PF13541;PF01078;PF13335;
IPR003593;IPR045006;IPR004482;IPR025158;IPR000523;IPR027417;IPR020568;IPR014721;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype)
BQ2027_MB2921C
false
Mycobacterium tuberculosis
358
row_525283
false
null
6,625
O53551
MTPTHPTVTELLLPLSEIDDRGVYFEDSFTSWRDHIRHGAAIAAALRERLDPARPPHVGVLLQNTPFFSATLVAGALSGIVPVGLNPVRRGAALAGDIAKADCQLVLTGSGSAEVPADVEHINVDSPEWTDEVAAHRDTEVRFRSADLADLFMLIFTSGTSGDPKAVKCSHRKVAIAGVTITQRFSLGRDDVCYVSMPLFHSNAVLVGWAVAAACQGSMALRRKFSASQFLADVRRYGATYANYVGKPLSYVLATPELPDDADNPLRAVYGNEGVPGDIDRFGRRFGCVVMDGFGSTEGGVAITRTLDTPAGALGPLPGGIQIVDPDTGEPCPTGVVGELVNTAGPGGFEGYYNDEAAEAERMAGGVYHSGDLAYRDDAGYAYFAGRLGDWMRVDGENLGTAPIERVLMRYPDATEVAVYPVPDPVVGDQVMAALVLAPGTKFDADKFRAFLTEQPDLGHKQWPSYVRVSAGLPRTMTFKVIKRQLSAEGVACADPVWPIRR
Medium/long-chain-fatty-acid--CoA ligase FadD17 (FACL) (EC 6.2.1.2) (EC 6.2.1.3) (Acyl-CoA synthetase) (FACL17) (Steroid-24-oyl-CoA synthetase)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
502
53,739
ATP-binding;Fatty acid metabolism;Ligase;Lipid metabolism;Nucleotide-binding;Reference proteome
GO:0001676; GO:0004467; GO:0005324; GO:0005524; GO:0005829; GO:0005886; GO:0008610; GO:0031956; GO:0042759; GO:0044539; GO:0047747; GO:0071766
Evidence at protein level
5
null
null
null
PF00501;PF13193;
IPR025110;IPR045851;IPR020845;IPR000873;IPR042099;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
fadD17 Rv3506
false
Mycobacterium tuberculosis
359
row_5459
false
null
81,804
P9WKB9
MPRGCAGARFACNACLNFLAGLGISEPISPGWAAMERLSGLDAFFLYMETPSQPLNVCCVLELDTSTMPGGYTYGRFHAALEKYVKAAPEFRMKLADTELNLDHPVWVDDDNFQIRHHLRRVAMPAPGGRRELAEICGYIAGLPLDRDRPLWEMWVIEGGARSDTVAVMLKVHHAVVDGVAGANLLSHLCSLQPDAPAPQPVRGTGGGNVLQIAASGLEGFASRPVRLATVVPATVLTLVRTLLRAREGRTMAAPFSAPPTPFNGPLGRLRNIAYTQLDMRDVKRVKDRFGVTINDVVVALCAGALRRFLLEHGVLPEAPLVATVPVSVHDKSDRPGRNQATWMFCRVPSQISDPAQRIRTIAAGNTVAKDHAAAIGPTLLHDWIQFGGSTMFGAAMRILPHISITHSPAYNLILSNVPGPQAQLYFLGCRMDSMFPLGPLLGNAGLNITVMSLNGELGVGIVSCPDLLPDLWGVADGFPEALKELLECSDDQPEGSNHQDS
Putative diacyglycerol O-acyltransferase Rv1760 (EC 2.3.1.20) (Putative triacylglycerol synthase Rv1760)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
502
54,092
Acyltransferase;Glycerol metabolism;Lipid biosynthesis;Lipid metabolism;Reference proteome;Transferase
GO:0001666; GO:0004144; GO:0005886; GO:0006071; GO:0008374; GO:0019432; GO:0045017; GO:0051701; GO:0071731
Evidence at protein level
4
null
null
null
PF06974;PF03007;
IPR014292;IPR023213;IPR045034;IPR009721;IPR004255;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
Rv1760 MTCY28.26
false
Mycobacterium tuberculosis
360
row_72250
false
null
6,595
O50406
METFRTLLAKAALGNGISSTAYDTAWVAKLGQLDDELSDLALNWLCERQLPDGSWGAEFPFCYEDRLLSTLAAMISLTSNKHRRRRAAQVEKGLLALKNLTSGAFEGPQLDIKDATVGFELIAPTLMAEAARLGLAICHEESILGELVGVREQKLRKLGGSKINKHITAAFSVELAGQDGVGMLDVDNLQETNGSVKYSPSASAYFALHVKPGDKRALAYISSIIQAGDGGAPAFYQAEIFEIVWSLWNLSRTDIDLSDPEIVRTYLPYLDHVEQHWVRGRGVGWTGNSTLEDCDTTSVAYDVLSKFGRSPDIGAVLQFEDADWFRTYFHEVGPSISTNVHVLGALKQAGYDKCHPRVRKVLEFIRSSKEPGRFCWRDKWHRSAYYTTAHLICAASNYDDALCSDAIGWILNTQRPDGSWGFFDGQATAEETAYCIQALAHWQRHSGTSLSAQISRAGGWLSQHCEPPYAPLWIAKTLYCSATVVKAAILSALRLVDESNQ
Type B diterpene cyclase (EC 5.5.1.16)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
501
55,262
3D-structure;Isomerase;Lyase;Magnesium;Metal-binding;Reference proteome
GO:0000287; GO:0010333; GO:0010350; GO:0033385; GO:0035439; GO:0035440
Evidence at protein level
5
null
null
null
PF13243;
IPR032696;IPR050148;IPR008930;
6VPT;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
Rv3377c
false
Mycobacterium tuberculosis
361
row_5430
false
null
26,753
P9WGL5
MSTLGDLLAEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWVRRDDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSMPLVAATFSGGVPGREGAVGQQNSCQHDGHSVEVSPVRFGDQVVAVLTRHQPELAARRRSGHLETAYRLCATDLLRMLAEGTFPDAGDVAMSRSSPRAGDGFIRLDVDGVVSYASPNALSAYHRMGLTTELEGVNLIDATRPLISDPFEAHEVDEHVQDLLAGDGKGMRMEVDAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRALISKDATIREIHHRVKNNLQTVAALLRLQARRTSNAEGREALIESVRRVSSIALVHDALSMSVDEQVNLDEVIDRILPIMNDVASVDRPIRINRVGDLGVLDSDRATALIMVITELVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGFSLEKSDSLGLQIVRTLVSAELDGSLGMRDARERGTDVVLRVPVGRRGRLML
Sensor histidine kinase PdtaS (EC 2.7.13.3) (c-di-GMP sensing sensor histidine kinase PdtaS)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
501
54,012
3D-structure;ATP-binding;Cytoplasm;Kinase;Nucleotide-binding;Phosphoprotein;Reference proteome;Stress response;Transferase;Two-component regulatory system
GO:0000155; GO:0000160; GO:0004672; GO:0005524; GO:0005737
Evidence at protein level
5
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:34003742}.
null
null
PF12282;PF02518;PF07568;
IPR038424;IPR036890;IPR005467;IPR035965;IPR022066;IPR011495;
2YKF;2YKH;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
pdtaS Rv3220c
false
Mycobacterium tuberculosis
362
row_23400
false
null
213,121
P9WPR5
MTTAQAAESQNPYLEGFLAPVSTEVTATDLPVTGRIPEHLDGRYLRNGPNPVAEVDPATYHWFTGDAMVHGVALRDGKARWYRNRWVRTPAVCAALGEPISARPHPRTGIIEGGPNTNVLTHAGRTLALVEAGVVNYELTDELDTVGPCDFDGTLHGGYTAHPQRDPHTGELHAVSYSFARGHRVQYSVIGTDGHARRTVDIEVAGSPMMHSFSLTDNYVVIYDLPVTFDPMQVVPASVPRWLQRPARLVIQSVLGRVRIPDPIAALGNRMQGHSDRLPYAWNPSYPARVGVMPREGGNEDVRWFDIEPCYVYHPLNAYSECRNGAEVLVLDVVRYSRMFDRDRRGPGGDSRPSLDRWTINLATGAVTAECRDDRAQEFPRINETLVGGPHRFAYTVGIEGGFLVGAGAALSTPLYKQDCVTGSSTVASLDPDLLIGEMVFVPNPSARAEDDGILMGYGWHRGRDEGQLLLLDAQTLESIATVHLPQRVPMGFHGNWAPTT
Carotenoid cleavage oxygenase (CCO) (EC 1.13.11.-) (Carotenoid 13,14/15,15'-oxygenase)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
501
54,944
Dioxygenase;Iron;Metal-binding;Oxidoreductase;Reference proteome
GO:0010436; GO:0016118; GO:0016121; GO:0046872
Evidence at protein level
3
null
null
null
PF03055;
IPR004294;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
Rv0654
false
Mycobacterium tuberculosis
363
row_199321
false
null
26,378
P96264
MVNKSRMMPAVLAVAVVVAFLTTGCIRWSTQSRPVVNGPAAAEFAVALRNRVSTDAMMAHLSKLQDIANANDGTRAVGTPGYQASVDYVVNTLRNSGFDVQTPEFSARVFKAEKGVVTLGGNTVEARALEYSLGTPPDGVTGPLVAAPADDSPGCSPSDYDRLPVSGAVVLVDRGVCPFAQKEDAAAQRGAVALIIADNIDEQAMGGTLGANTDVKIPVVSVTKSVGFQLRGQSGPTTVKLTASTQSFKARNVIAQTKTGSSANVVMAGAHLDSVPEGPGINDNGSGVAAVLETAVQLGNSPHVSNAVRFAFWGAEEFGLIGSRNYVESLDIDALKGIALYLNFDMLASPNPGYFTYDGDQSLPLDARGQPVVPEGSAGIERTFVAYLKMAGKTAQDTSFDGRSDYDGFTLAGIPSGGLFSGAEVKKSAEQAELWGGTADEPFDPNYHQKTDTLDHIDRTALGINGAGVAYAVGLYAQDLGGPNGVPVMADRTRHLIAKP
Probable lipoprotein aminopeptidase LpqL (EC 3.4.11.1) (Leucine aminopeptidase) (Lipoprotein LpqL)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
500
52,042
Aminopeptidase;Cell membrane;Hydrolase;Lipoprotein;Membrane;Metal-binding;Palmitate;Protease;Reference proteome;Signal;Zinc
GO:0004177; GO:0005576; GO:0005886; GO:0006508; GO:0008235; GO:0046872
Evidence at protein level
5
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000305|PubMed:24093492}.
SIGNAL 1..24; /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
null
PF02225;PF04389;
IPR045175;IPR041756;IPR046450;IPR003137;IPR007484;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
lpqL Rv0418
false
Mycobacterium tuberculosis
364
row_23090
false
null
26,951
P9WN11
MAPSGGQEAQICDSETFGDSDFVVVANRLPVDLERLPDGSTTWKRSPGGLVTALEPVLRRRRGAWVGWPGVNDDGAEPDLHVLDGPIIQDELELHPVRLSTTDIAQYYEGFSNATLWPLYHDVIVKPLYHREWWDRYVDVNQRFAEAASRAAAHGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQMPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGTDTSRGTVGVRSRFGAAVLGSRTIRVGAFPISVDSGALDHAARDRNIRRRAREIRTELGNPRKILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVVVQLATPSRERVESYQTLRNDIERQVGHINGEYGEVGHPVVHYLHRPAPRDELIAFFVASDVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLEGVKDGIEEALNQTEEAGRRRMRSLRRQVLAHDVDRWAQSFLDALAGAHPRGQG
Trehalose-6-phosphate synthase (TPS) (EC 2.4.1.15) (EC 2.4.1.347) (Alpha,alpha-trehalose-phosphate synthase [UDP-forming]) (Osmoregulatory trehalose synthesis protein A) (OtsA)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
500
55,862
Glycosyltransferase;Reference proteome;Transferase
GO:0003825; GO:0005829; GO:0005886; GO:0005992; GO:0009274; GO:0030145; GO:0047260
Evidence at protein level
5
null
null
null
PF00982;
IPR001830;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
otsA Rv3490
false
Mycobacterium tuberculosis
365
row_23591
false
null
26,829
P9WIF5
MSFVVTIPEALAAVATDLAGIGSTIGTANAAAAVPTTTVLAAAADEVSAAMAALFSGHAQAYQALSAQAALFHEQFVRALTAGAGSYAAAEAASAAPLEGVLDVINAPALALLGRPLIGNGANGAPGTGANGGDGGILIGNGGAGGSGAAGMPGGNGGAAGLFGNGGAGGAGGNVASGTAGFGGAGGAGGLLYGAGGAGGAGGRAGGGVGGIGGAGGAGGNGGLLFGAGGAGGVGGLAADAGDGGAGGDGGLFFGVGGAGGAGGTGTNVTGGAGGAGGNGGLLFGAGGVGGVGGDGVAFLGTAPGGPGGAGGAGGLFGVGGAGGAGGIGLVGNGGAGGSGGSALLWGDGGAGGAGGVGSTTGGAGGAGGNAGLLVGAGGAGGAGALGGGATGVGGAGGNGGTAGLLFGAGGAGGFGFGGAGGAGGLGGKAGLIGDGGDGGAGGNGTGAKGGDGGAGGGAILVGNGGNGGNAGSGTPNGSAGTGGAGGLLGKNGMNGLP
PE-PGRS family protein PE_PGRS33
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
498
40,755
Calcium;Cell outer membrane;Cell wall;Membrane;Reference proteome;Secreted;Virulence
GO:0005576; GO:0009274; GO:0009279; GO:0009986; GO:0042594; GO:0044650; GO:0046789; GO:0052167; GO:0070482
Evidence at protein level
5
SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000269|PubMed:15101979, ECO:0000269|PubMed:18028308, ECO:0000269|PubMed:22110736, ECO:0000269|PubMed:27483162}. Cell surface {ECO:0000269|PubMed:15101979, ECO:0000269|PubMed:18028308, ECO:0000269|PubMed:18957600, ECO:0000269|PubMed:22110736, ECO:0000269|PubMed:27483162}. Cell outer membrane {ECO:0000269|PubMed:18028308}. Note=Exported to the cell surface via the ESX-5 / type VII secretion system (T7SS) (PubMed:22110736). Localizes mostly at the cell poles (PubMed:15101979). Colocalizes to mitochondria in transfected eukaryotic cells (PubMed:17223373, PubMed:21081760). {ECO:0000269|PubMed:15101979, ECO:0000269|PubMed:17223373, ECO:0000269|PubMed:21081760, ECO:0000269|PubMed:22110736}.
null
null
PF00934;PF21526;
IPR000084;IPR048996;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
PE_PGRS33 Rv1818c MTCY1A11.25c
false
Mycobacterium tuberculosis
366
row_23474
false
null
431,833
P9WLN2
MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPVVTDFCDFRTAEQRERACIREFELNSRLAAQSYLGIAHLSDPSGGHAEPVVVMRRYRDKQRLASMVTAGLPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAELRHHADKVVSGDVIRRIEHMVDEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALLDCLEFEDELRYLDRIDDAAFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIAYRAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQHATVRLALVGGNPGTGKSTLARGVAELVGAQVISTDDVRRRLRDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLGSGHSVILDGTWGDPQMRACARRLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAALAARQADWDTGHRIDTAGPRERSVGQAYHIWRSAI
Uncharacterized protein MT2060
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
498
54,423
ATP-binding;Cell wall;Nucleotide-binding;Reference proteome;Secreted
GO:0005524; GO:0005576
Evidence at transcript level
2
SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}.
null
null
PF13671;
IPR052732;IPR011009;IPR027417;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
MT2060
false
Mycobacterium tuberculosis
367
row_413588
false
null
81,799
P9WKA7
MSQTARRLGPQDMFFLYSESSTTMMHVGALMPFTPPSGAPPDLLRQLVDESKASEVVEPWSLRLSHPELLYHPTQSWVVDDNFDLDYHVRRSALASPGDERELGIPVSRLHSHALDLRRPPWEVHFIEGLEGGRFAIYIKMHHSLIDGYTGQKMLARSLSTDPHDTTHPLFFNIPTPGRSPADTQDSVGGGLIAGAGNVLDGLGDVVRGLGGLVSGVGSVLGSVAGAGRSTFELTKALVNAQLRSDHEYRNLVGSVQAPHCILNTRISRNRRFATQQYPLDRLKAIGAQYDATINDVALAIIGGGLRRFLDELGELPNKSLIVVLPVNVRPKDDEGGGNAVATILATLGTDVADPVQRLAAVTASTRAAKAQLRSMDKDAILAYSAALMAPYGVQLASTLSGVKPPWPYTFNLCVSNVPGPEDVLYLRGSRMEASYPVSLVAHSQALNVTLQSYAGTLNFGFIGCRDTLPHLQRLAVYTGEALDQLAAADGAAGLGS
Putative diacyglycerol O-acyltransferase Rv3480c (EC 2.3.1.20) (Putative triacylglycerol synthase Rv3480c)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
497
53,315
Acyltransferase;Glycerol metabolism;Lipid biosynthesis;Lipid metabolism;Reference proteome;Transferase
GO:0001666; GO:0004144; GO:0005886; GO:0006071; GO:0008374; GO:0019432; GO:0045017; GO:0047196; GO:0051701; GO:0071731
Evidence at protein level
4
null
null
null
PF06974;PF03007;
IPR014292;IPR045034;IPR009721;IPR004255;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
Rv3480c MTCY13E12.33c
false
Mycobacterium tuberculosis
368
row_72245
false
null
26,875
P9WJW2
MHDDFERCYRAIQSKDARFDGWFVVAVLTTGVYCRPSCPVRPPFARNVRFLPTAAAAQGEGFRACKRCRPDASPGSPEWNVRSDVVARAMRLIADGTVDRDGVSGLAAQLGYTIRQLERLLQAVVGAGPLALARAQRMQTARVLIETTNLPFGDVAFAAGFSSIRQFNDTVRLACDGTPTALRARAAARFESATASAGTVSLRLPVRAPFAFEGVFGHLAATAVPGCEEVRDGAYRRTLRLPWGNGIVSLTPAPDHVRCLLVLDDFRDLMTATARCRRLLDLDADPEAIVEALGADPDLRAVVGKAPGQRIPRTVDEAEFAVRAVLAQQVSTKAASTHAGRLVAAYGRPVHDRHGALTHTFPSIEQLAEIDPGHLAVPKARQRTINALVASLADKSLVLDAGCDWQRARGQLLALPGVGPWTAEVIAMRGLGDPDAFPASDLGLRLAAKKLGLPAQRRALTVHSARWRPWRSYATQHLWTTLEHPVNQWPPQEKIA
Probable bifunctional transcriptional activator/DNA repair enzyme AlkA (Regulatory protein AlkA) [Includes: Methylphosphotriester-DNA--protein-cysteine S-methyltransferase (EC 2.1.1.n11) (Methylphosphotriester-DNA methyltransferase); DNA-3-methyladenine glycosylase (EC 3.2.2.21) (DNA-3-methyladenine glycosidase)]
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
496
53,743
Activator;DNA damage;DNA repair;DNA-binding;Hydrolase;Metal-binding;Methyltransferase;Multifunctional enzyme;Reference proteome;Transcription;Transcription regulation;Transferase;Zinc
GO:0003700; GO:0005737; GO:0006285; GO:0006307; GO:0008168; GO:0008270; GO:0008725; GO:0032131; GO:0032259; GO:0032993; GO:0043565; GO:0043916
Inferred from homology
5
null
null
null
PF02805;PF06029;PF00730;PF12833;
IPR035451;IPR004026;IPR010316;IPR037046;IPR051912;IPR011257;IPR003265;IPR023170;IPR009057;IPR018060;IPR018062;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
alkA ada MT1358
false
Mycobacterium tuberculosis
369
row_23516
false
null
62,174
A5U4I2
MSGLPRSVPDVLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFRLGEPAARELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATAVRAVIR
UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase)
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
419,947
496
50,354
ATP-binding;Cell cycle;Cell division;Cell shape;Cell wall biogenesis/degradation;Cytoplasm;Ligase;Nucleotide-binding;Peptidoglycan synthesis;Phosphoprotein;Reference proteome
GO:0005524; GO:0005737; GO:0008360; GO:0008764; GO:0009252; GO:0051301; GO:0071555
Evidence at protein level
4
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00639}.
null
null
PF02875;PF08245;
IPR036565;IPR004101;IPR036615;IPR013221;IPR005762;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
murD MRA_2170
false
Mycobacterium tuberculosis
370
row_53839
false
null
181,871
L0T2H7
MSLLITSPATVAAAATHLAGIGSALSTANAAAAAPTTALSVAGADEVSVLIAALFEAYAQEYQALSAQALAFHDQFVQALNMGAVCYAAAETANATPLQALQTVQQNVLTVVNAPTQALLGRPIIGNGANGLPNTGQDGGPGGLLFGNGGNGGSGGVDQAGGNGGAAGLIGNGGSGGVGGPGIAGSAGGAGGAGGLLFGNGGPGGAGGIGTTGDGGPGGAGGNAIGLFGSGGTGGMGGVGGMGGVGNGGNAGNGGTAGLFGHGGAGGAGGIGSADGGLGGGGGNGRFMGNGGVGGAGGYGASGDGGNAGNGGLGGVFGDGGAGGTGGLGDVNGGLAGIGGNAGFVRNGGAGGNGQLGSGAVSSAGGMGGNGGLVFGNGGPGGLGGPGTSAGNGGMGGNAVGLFGQGGAGGAGGSGFGAGIPGGRGGDGGSGGLIGDGGTGGGAGAGDAAASAGGNGGNARLIGNGGDGGPGMFGGPGGAGGSGGTIFGFAGTPGPS
PE-PGRS family protein PE_PGRS1 (Late stage specific Rv0109 protein)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
496
42,289
Cell wall;Host mitochondrion;Reference proteome;Secreted;Virulence
GO:0005576; GO:0033650
Evidence at transcript level
3
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:36584479}. Secreted, cell wall {ECO:0000269|PubMed:36584479}. Host mitochondrion {ECO:0000269|PubMed:36739922}. Note=Localizes to the cell wall when expressed in M.smegmatis (PubMed:36584479). Localizes to mitochondria of macrophage when expressed in THP-1 macrophages (PubMed:36739922). {ECO:0000269|PubMed:36584479, ECO:0000269|PubMed:36739922}.
null
null
PF00934;PF21526;
IPR000084;IPR048996;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
PE_PGRS1 Rv0109
false
Mycobacterium tuberculosis
371
row_168908
false
null
430,781
P96284
MIEEQRTMSVEGADQQSEKLFHYLKKVAVELDETRARLREYEQRATEPVAVVGIGCRFPGGVDGPDGLWDVVSAGRDVVSEFPTDRGWDVEGLYDPDPDAEGKTYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEHAGIDPLSLRGSATGVYTGIFAASYGNRDTGGLQGYGLTGTSISVASGRVSYVLGLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRLGHSVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQVALANAGLSAADVDVVEAHGTATTLGDPIEAQALLSTYGQGGPAEQPLWVGSIKSNMGHTQAAAGVAGVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREWSVDGRPRRAAVSSFGISGTNAHLILEEAPVPAPAEAPVEASESTGGRGRRWCRG
Putative inactive phenolphthiocerol synthesis polyketide synthase type I Pks15
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
496
51,702
Reference proteome;Transferase
GO:0004315; GO:0005829; GO:0006633; GO:0009247; GO:0016020
Evidence at protein level
2
null
null
null
PF16197;PF00109;PF02801;
IPR018201;IPR014031;IPR014030;IPR032821;IPR020841;IPR050091;IPR036299;IPR016039;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
pks15 Rv2947c
false
Mycobacterium tuberculosis
372
row_412543
false
null
26,769
P9WGV3
MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY
Adenosylhomocysteinase (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
495
54,324
3D-structure;Cytoplasm;Hydrolase;Isopeptide bond;NAD;One-carbon metabolism;Reference proteome;Ubl conjugation
GO:0004013; GO:0005576; GO:0005829; GO:0005886; GO:0006730; GO:0009087; GO:0009274; GO:0033353; GO:0035375; GO:0035635; GO:0044650; GO:0046085; GO:0070403; GO:0071269
Evidence at protein level
5
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00563}.
null
null
PF05221;PF00670;
IPR042172;IPR000043;IPR015878;IPR036291;IPR020082;
2ZIZ;2ZJ0;2ZJ1;3CE6;3DHY;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
ahcY sahH Rv3248c MTCY20B11.23c
false
Mycobacterium tuberculosis
373
row_23416
false
null
26,932
P9WMN2
MTFPGDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIAKLAPQRLIVVLGHDHQRIAPLVGELADTLGRTIDVALQDRPLGTGHAVLCGLSALPDDYAGNVVVTSGDTPLLDADTLADLIATHRAVSAAVTVLTTTLDDPFGYGRILRTQDHEVMAIVEQTDATPSQREIREVNAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILRSDGQTVHASHVDDSALVAGVNNRVQLAELASELNRRVVAAHQLAGVTVVDPATTWIDVDVTIGRDTVIHPGTQLLGRTQIGGRCVVGPDTTLTDVAVGDGASVVRTHGSSSSIGDGAAVGPFTYLRPGTALGADGKLGAFVEVKNSTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYDGTSKRRTTVGSHVRTGSDTMFVAPVTIGDGAYTGAGTVVREDVPPGALAVSAGPQRNIENWVQRKRPGSPAAQASKRASEMACQQPTQPPDADQTP
Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)]
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
495
51,584
3D-structure;Acyltransferase;Cell shape;Cell wall biogenesis/degradation;Cytoplasm;Magnesium;Metal-binding;Multifunctional enzyme;Nucleotidyltransferase;Peptidoglycan synthesis;Reference proteome;Repeat;Transferase
GO:0000287; GO:0000902; GO:0003977; GO:0005737; GO:0006048; GO:0008360; GO:0009245; GO:0009252; GO:0016020; GO:0019134; GO:0071555
Evidence at protein level
5
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01631}.
null
null
PF00132;PF12804;
IPR005882;IPR050065;IPR038009;IPR001451;IPR025877;IPR029044;IPR011004;
4K6R;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
glmU MT1046
false
Mycobacterium tuberculosis
374
row_23573
false
null
81,872
P9WNF7
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMFTFGYKFRPWRDVKVLADGASIRQYIADTATEFGVDEKIHYGLKVNTAEWSSRQCRWTVAGVHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFGGRCVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVYEFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAVPNGDLFKTLASGAASVVTDQIETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIVDGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSDIAGAYLCRLLRHMADNGYTVATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDDGVLHFAAAAQDHAAA
Putative FAD-containing monooxygenase MymA (EC 1.14.13.-)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
495
55,482
FAD;Flavoprotein;Monooxygenase;Oxidoreductase;Reference proteome
GO:0004499; GO:0009274; GO:0010447; GO:0050660; GO:0050661; GO:0051701
Evidence at protein level
4
null
null
null
PF00743;PF13450;
IPR051820;IPR036188;IPR020946;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
mymA Rv3083
false
Mycobacterium tuberculosis
375
row_72315
false
null
213,226
P9WQH9
MSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADESVQTGEGRVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASPSSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSLGHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRALTVLIDAPEPLPAPQTPAPVPDVPTWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQPTVVLGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPALSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLPADRVLAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYRRIGLPRD
Probable biotin-dependent acyl-coenzyme A carboxylase beta3 subunit (EC 2.1.3.-)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
495
51,772
Reference proteome;Transferase
GO:0003989; GO:0005886; GO:0009317; GO:0016740; GO:0071768
Evidence at protein level
3
null
null
null
PF01039;
IPR034733;IPR000438;IPR029045;IPR011763;IPR011762;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
accD3 Rv0904c MTCY31.32c
false
Mycobacterium tuberculosis
376
row_199424
false
null
425,773
P64746
MTGRCPTVAVVGAGMSGMCVAITLLSAGITDVCIYEKADDVGGTWRDNTYPGLTCDVPSRLYQYSFAKNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDDGRWVLRTDSGTESTVDFLISATGVLHHPRIPPIAGLDDFRGTVFHSARWDHTVPLLGRRIAVIGTGSTGVQLVCGLAGVAGKVTMFQRTAQWVLPWPNPRYSKLARVFHRAFPCLGSLAYKAYSLSFETFAVALSNPGLHRKLVGAVCRASLRRVRDPRLRRALTPDYEPMCKRLVMSGGFYRAIQRDDVELVTAGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHAFFRPMQLTGRDGIRIDDVWQDGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQAEHIVQWIKRWRHGEFDTMEPKSAATEAYNTVLRAAMPNTVWTTGCDSWYLNKDGIPEVWPFAPAKHRAMLANLHPEEYDLRRYAAVRATSRPQSA
Uncharacterized monooxygenase Mb0916 (EC 1.14.13.-)
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
233,413
495
55,039
FAD;Flavoprotein;Monooxygenase;NADP;Oxidoreductase;Reference proteome
GO:0004499; GO:0050660; GO:0050661
Inferred from homology
2
null
null
null
PF00743;
IPR051209;IPR036188;IPR020946;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype)
BQ2027_MB0916
false
Mycobacterium tuberculosis
377
row_407867
false
null
432,051
P9WNR4
MPLSLSNRDQNSGHLFYNRRLRAATTRFSVRMKHDDRKQTAALALSMVLVAIAAGWMMLLNVLKPTGIVGDSAIIGDRDSGALYARIDGRLYPALNLTSARLATGTAGQPTWVKPAEIAKYPTGPLVGIPGAPAAMPVNRGAVSAWAVCDTAGRPRSADKPVVTSIAGPITGGGRATHLRDDAGLLVTFDGSTYVIWGGKRSQIDPTNRAVTLSLGLDPGVTSPIQISRALFDGLPATEPLRVPAVPEAGTPSTWVPGARVGSVLQAQTAGGGSQFYVLLPDGVQKISSFVADLLRSANSYGAAAPRVVTPDVLVHTPQVTSLPVEYYPAGRLNFVDTAADPTTCVSWEKASTDPQARVAVYNGRGLPVPPSMDSRIVRLVRDDRAPASVVATQVLVLPGAANFVTSTSGVITAESRESLFWVSGNGVRFGIANDEATLRALGLDPGAAVQAPWPLLRTFAAGPALSRDAALLARDTVPTLGQVAIVTTTAKAGA
ESX-2 secretion system ATPase EccB2 (EC 3.6.-.-) (ESX conserved component B2) (Type VII secretion system protein EccB2) (T7SS protein EccB2)
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
495
51,587
ATP-binding;Cell membrane;Hydrolase;Membrane;Nucleotide-binding;Reference proteome;Transmembrane;Transmembrane helix
GO:0005524; GO:0005576; GO:0005886; GO:0016787
Inferred from homology
2
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
null
TRANSMEM 43..63; /note="Helical"; /evidence="ECO:0000255"
PF05108;
IPR007795;IPR044857;IPR042485;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
eccB2 MT4011
false
Mycobacterium tuberculosis
378
row_413798
false
null
112,202
A1KKJ5
MSTEQLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGVHALRARGALIRIGHDASSLDLLPGGATAVVTTHAAIPKTNPELVEARRRGIPVVLRPAVLAKLMAGRTTLMVTGTHGKTTTTSMLIVALQHCGLDPSFAVGGELGEAGTNAHHGSGDCFVAEADESDGSLLQYTPHVAVITNIESDHLDFYGSVEAYVAVFDSFVERIVPGGALVVCTDDPGGAALAQRATELGIRVLRYGSVPGETMAATLVSWQQQGVGAVAHIRLASELATAQGPRVMRLSVPGRHMALNALGALLAAVQIGAPADEVLDGLAGFEGVRRRFELVGTCGVGKASVRVFDDYAHHPTEISATLAAARMVLEQGDGGRCMVVFQPHLYSRTKAFAAEFGRALNAADEVFVLDVYGAREQPLAGVSGASVAEHVTVPMRYVPDFSAVAQQVAAAASPGDVIVTMGAGDVTLLGPEILTALRVRANRSAPGRPGVLG
UDP-N-acetylmuramate--L-alanine ligase (EC 6.3.2.8) (UDP-N-acetylmuramoyl-L-alanine synthetase)
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
410,289
494
51,177
ATP-binding;Cell cycle;Cell division;Cell shape;Cell wall biogenesis/degradation;Cytoplasm;Ligase;Nucleotide-binding;Peptidoglycan synthesis
GO:0005524; GO:0005737; GO:0008360; GO:0008763; GO:0009252; GO:0051301; GO:0071555
Inferred from homology
3
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00046}.
null
null
PF01225;PF02875;PF08245;
IPR036565;IPR004101;IPR036615;IPR013221;IPR000713;IPR050061;IPR005758;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype), Mycobacterium tuberculosis variant bovis BCG (no rank)
murC BCG_2169c
false
Mycobacterium tuberculosis
379
row_100667
false
null
320,998
A1KF76
MSGLLVAGTTSDAGKSAVTAGLCRALARRGVRVAPFKAQNMSNNSMVCRGPDGTGVEIGRAQWVQALAARTTPEAAMNPVLLKPASDHRSHVVLMGKPWGEVASSSWCAGRRALAEAACRAFDALAARYDVVVAEGAGSPAEINLRAGDYVNMGLARHAGLPTIVVGDIDRGGVFAAFLGTVALLAAEDQALVAGFVVNKFRGDSDLLAPGLRDLERVTGRRVYGTLPWHPDLWLDSEDALDLQGRRAAGTGARRVAVVRLPRISNFTDVDALGLEPDLDVVFASDPRALDDADLIVLPGTRATIADLAWLRARDLDRALLVHVAAGKPLLGICGGFQMLGRVIRDPYGIEGPGGQVTEVEGLGLLDVETAFSPHKVLRLPRGEGLGVPASGYEIHHGRITRGDTAEEFLGGARDGPVFGTMWHGSLEGDALREAFLRETLGLAPSGSCFLAARERRLDLLGDLVERHLDVDALLNLARHGCPPTLPFLAPGAP
Cobyric acid synthase
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
410,289
494
52,135
Cobalamin biosynthesis;Glutamine amidotransferase
GO:0003824; GO:0009236; GO:0015420
Inferred from homology
2
null
null
null
PF01656;PF07685;
IPR029062;IPR002586;IPR033949;IPR047045;IPR004459;IPR011698;IPR027417;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype), Mycobacterium tuberculosis variant bovis BCG (no rank)
cobQ BCG_0293c
false
Mycobacterium tuberculosis
380
row_304370
false
null
321,159
A1KN06
MTDIIRSDAATLAAKIAIKEVSSTEITRACLDQIEATDETYHAFLHVAADEALAAAAAVDKQVAAGEPLPSALAGVPLALKDVFTTSDMPTTCGSKILEGWRSPYDATLTARLRAAGIPILGKTNMDEFAMGSSTENSAYGPTRNPWNLDRVPGGSGGGSAAALAAFQAPLAIGSDTGGSIRQPAALTATVGVKPTYGTVSRYGLVACASSLDQGGPCARTVLDTALLHQVIAGHDPRDSTSVDAEVPDVVGAARAGAVGDLRGVRVGVVRQLHGGEGYQPGVLASFEAAVEQLTALGAEVSEVDCPHFDHALAAYYLILPSEVSSNLARFDAMRYGLRVGDDGTRSAEEVMAMTRAAGFGPEVKRRIMIGTYALSAGYYDAYYNQAQKVRTLIARDLDAAYRSVDVLVSPTTPTTAFRLGEKVDDPLAMYLFDLCTLPLNLAGHCGMSVPSGLSPDDGLPVGLQIMAPALADDRLYRVGAAYEAARGPLLSAI
Glutamyl-tRNA(Gln) amidotransferase subunit A (Glu-ADT subunit A) (EC 6.3.5.7)
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
410,289
494
51,436
ATP-binding;Ligase;Nucleotide-binding;Protein biosynthesis
GO:0005524; GO:0006412; GO:0030956; GO:0050567
Inferred from homology
2
null
null
null
PF01425;
IPR000120;IPR020556;IPR023631;IPR036928;IPR004412;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype), Mycobacterium tuberculosis variant bovis BCG (no rank)
gatA BCG_3033c
false
Mycobacterium tuberculosis
381
row_304531
false
null
26,784
P9WHH7
MVTRIVILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAVLDDCVPSKTFIASTGLRTELRRAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADITAQLLSMGVQVIAGRGELIDSTPGLARHRIKATAADGSTSEHEADVVLVATGASPRILPSAQPDGERILTWRQLYDLDALPDHLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLPYEDADAALVLEESFAERGVRLFKNARAASVTRTGAGVLVTMTDGRTVEGSHALMTIGSVPNTSGLGLERVGIQLGRGNYLTVDRVSRTLATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVSPIRLRTVAATVFTRPEIAAVGVPQSVIDAGSVAARTIMLPLRTNARAKMSEMRHGFVKIFCRRSTGVVIGGVVVAPIASELILPIAVAVQNRITVNELAQTLAVYPSLSGSITEAARRLMAHDDLDCTAAQDAAEQLALVPHHLPTSN
NAD(P)H dehydrogenase (quinone) (EC 1.6.5.2) (NAD(P)H quinone reductase) (NAD(P)H: menadione oxidoreductase) (NADH-menadione reductase)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
493
51,489
3D-structure;FAD;Flavoprotein;NAD;Oxidoreductase;Reference proteome
GO:0003955; GO:0008753; GO:0016655; GO:0050136; GO:0050660; GO:0070401; GO:1990748
Evidence at protein level
5
null
null
null
PF07992;PF02852;
IPR036188;IPR023753;IPR016156;IPR001100;IPR004099;
1XDI;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
lpdA lpdA-2 Rv3303c
false
Mycobacterium tuberculosis
382
row_23430
false
null
321,139
A1KMJ5
MSDLARTDVVLIGAGIMSATLGVLLRRLEPNWSITLIERLDAVAAESSGPWNNAGTGHSALCEMNYTPEMPDGSIDITKAVRVNEQFQVTRQFWAYAAENGILTDVRSFLNPVPHVSFVHGSRGVEYLRRRQKALAGNPLFAGTEFIESPDEFARRLPFMAAKRAFSEPVALNWAADGTDVDFGALAKQLIGYCVQNGTTALFGHEVRNLSRQSDGSWTVTMCNRRTGEKRKLNTKFVFVGAGGDTLPVLQKSGIKEVKGFAGFPIGGRFLRAGNPALTASHRAKVYGFPAPGAPPLGALHLDLRFVNGKSWLVFGPYAGWSPKFLKHGQISDLPRSIRPDNLLSVLGVGLTERRLLNYLISQLRLSEPERVSALREFAPSAIDSDWELTIAGQRVQVIRRDERNGGVLEFGTTVIGDADGSIAGLLGGSPGASTAVAIMLDVLQKCFANRYQSWLPTLKEMVPSLGVQLSNEPALFDEVWSWSTKALKLGAA
Probable malate:quinone oxidoreductase (EC 1.1.5.4) (MQO) (Malate dehydrogenase [quinone])
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
410,289
493
53,595
FAD;Flavoprotein;Oxidoreductase;Tricarboxylic acid cycle
GO:0006099; GO:0008924; GO:0047545
Inferred from homology
2
null
null
null
PF06039;
IPR036188;IPR006231;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype), Mycobacterium tuberculosis variant bovis BCG (no rank)
mqo BCG_2872c
false
Mycobacterium tuberculosis
383
row_304511
false
null
546,592
P9WJ94
MSTSDRVRAILHATIQAYRGAPAYRQRGDVFCQLDRIGARLAEPLRIALAGTLKAGKSTLVNALVGDDIAPTDATEATRIVTWFRHGPTPRVTANHRGGRRANVPITRRGGLSFDLRRINPAELIDLEVEWPAEELIDATIVDTPGTSSLACDASERTLRLLVPADGVPRVDAVVFLLRTLNAADVALLKQIGGLVGGSVGALGIIGVASRADEIGAGRIDAMLSANDVAKRFTRELNQMGICQAVVPVSGLLALTARTLRQTEFIALRKLAGAERTELNRALLSVDRFVRRDSPLPVDAGIRAQLLERFGMFGIRMSIAVLAAGVTDSTGLAAELLERSGLVALRNVIDQQFAQRSDMLKAHTALVSLRRFVQTHPVPATPYVIADIDPLLADTHAFEELRMLSLLPSRATTLNDDEIASLRRIIGGSGTSAAARLGLDPANSREAPRAALAAAQHWRRRAAHPLNDPFTTRACRAAVRSAEAMVAEFSARR
Isoniazid-induced protein IniC
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
493
53,019
Reference proteome
null
Predicted
1
null
null
null
PF00350;
IPR045063;IPR027417;IPR051943;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
iniC MT0357.1
false
Mycobacterium tuberculosis
384
row_526685
false
null
432,153
P9WPM6
MATIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKKLAEPPPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLPGVAALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHRRIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLDIASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRGLRARELLENYFTARVKERREASGNDLLTVLCQTEDDDGNRFSDADIVNHMIFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESLEQLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNHRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFDQLEIKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR
Putative cytochrome P450 136 (EC 1.14.-.-)
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
492
56,228
Heme;Iron;Metal-binding;Monooxygenase;Oxidoreductase;Reference proteome
GO:0004497; GO:0005506; GO:0016125; GO:0016705; GO:0020037
Inferred from homology
2
null
null
null
PF00067;
IPR001128;IPR017972;IPR002403;IPR036396;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
cyp136 MT3145
false
Mycobacterium tuberculosis
385
row_413898
false
null
26,892
P9WKD1
MNASLRRISVTVMALIVLLLLNATMTQVFTADGLRADPRNQRVLLDEYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSSTALERAEDPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTINPRIQQAGWDAMQQGCYGPCKGAVVALEPSTGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISETYPPGSTFKVITTAAALAAGATETEQLTAAPTIPLPGSTAQLENYGGAPCGDEPTVSLREAFVKSCNTAFVQLGIRTGADALRSMARAFGLDSPPRPTPLQVAESTVGPIPDSAALGMTSIGQKDVALTPLANAEIAATIANGGITMRPYLVGSLKGPDLANISTTVGYQQRRAVSPQVAAKLTELMVGAEKVAQQKGAIPGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQAPKVAVAVLVENGADRLSATGGALAAPIGRAVIEAALQGEP
Peptidoglycan D,D-transpeptidase PbpA (EC 3.4.16.4) (Penicillin-binding protein A) (PBPA)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
491
51,576
3D-structure;Cell inner membrane;Cell membrane;Cell shape;Cell wall biogenesis/degradation;Disulfide bond;Hydrolase;Membrane;Peptidoglycan synthesis;Reference proteome;Signal-anchor;Transmembrane;Transmembrane helix
GO:0005829; GO:0005886; GO:0008360; GO:0008658; GO:0009002; GO:0009252; GO:0071555; GO:0071972
Evidence at protein level
5
SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000255}.
null
TRANSMEM 8..28; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255"
PF21922;PF00905;
IPR050515;IPR012338;IPR054120;IPR001460;
3LO7;3UN7;3UPN;3UPO;3UPP;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
pbpA Rv0016c MTCY10H4.16c
false
Mycobacterium tuberculosis
386
row_23533
false
null
212,791
P9WKB3
MAESGESPRLSDELGPVDYLMHRGEANPRTRSGIMALELLDGTPDWDRFRTRFENASRRVLRLRQKVVVPTLPTAAPRWVVDPDFNLDFHVRRVRVSGPATLREVLDLAEVILQSPLDISRPLWTATLVEGMADGRAAMLLHVSHAVTDGVGGVEMFAQIYDLERDPPPRSTPPQPIPEDLSPNDLMRRGINHLPIAVVGGVLDALSGAVSMAGRAVLEPVSTVSGILGYARSGIRVLNRAAEPSPLLRRRSLTTRTEAIDIRLADLHKAAKAGGGSINDAYLAGLCGALRRYHEALGVPISTLPMAVPVNLRAEGDAAGGNQFTGVNLAAPVGTIDPVARMKKIRAQMTQRRDEPAMNIIGSIAPVLSVLPTAVLEGITGSVIGSDVQASNVPVYPGDTYLAGAKILRQYGIGPLPGVAMMVVLISRGGWCTVTVRYDRASVRNDELFAQCLQAGFDEILALAGGPAPRVLPASFDTQGAGSVPRSVSGS
Putative diacyglycerol O-acyltransferase Rv2484c (EC 2.3.1.20) (Putative triacylglycerol synthase Rv2484c)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
491
52,309
Acyltransferase;Glycerol metabolism;Lipid biosynthesis;Lipid metabolism;Reference proteome;Transferase
GO:0001666; GO:0004144; GO:0005886; GO:0006071; GO:0008374; GO:0019432; GO:0051701; GO:0071731
Evidence at protein level
3
null
null
null
PF06974;PF03007;
IPR014292;IPR023213;IPR045034;IPR009721;IPR004255;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
Rv2484c MTV008.40c
false
Mycobacterium tuberculosis
387
row_198995
false
null
276,531
Q79FP3
MSNVMVVPGMLSAAAADVASIGAALSAANGAAAPTTAGVLAAGADEVSAAIASLFSGYARDYQALSAQMARFHQQFVQALTASVGSYAAAEAANASPLQALEQQVLAAINAPTQTLLGRPLIGNGADGLPGQNGGAGGLLWGNGGNGGAGDAAHPNGGNGGDAGMFGNGGAGGAGYSPAAGTGAAGGAGGAGGAGGWLSGNGGAGGNGGTGASGADGGGGLPPVPASPGGNGGGGDAGGAAGMFGTGGAGGTGGDGGAGGAGDSPNSGANGARGGDGGNGAAGGAGGRLFGNGGAGGNGGTAGQGGDGGTALGAGGIGGDGGTGGAGGTGGTAGIGGSSAGAGGAGGDGGAGGTGGGSSMIGGKGGTGGNGGVGGTGGASALTIGNGSSAGAGGAGGAGGTGGTGGYIESLDGKGQAGNGGNGGNGAAGGAGGGGTGAGGNGGAGGNGGDGGPSQGGGNPGFGGDGGTGGPGGVGVPDGIGGANGAQGKHG
PE-PGRS family protein PE_PGRS26
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
491
40,810
Reference proteome
GO:0009986
Evidence at transcript level
3
SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:18957600}.
null
null
PF00934;PF21526;
IPR000084;IPR048996;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
PE_PGRS26 Rv1441c
false
Mycobacterium tuberculosis
388
row_260927
false
null
410,021
P0A688
MSFVIASPEALLAAATDLAAIRSTIRAANAAAAVPTTGALAPAADEVSAGIAALFGAQAQSYQAVSAQAAAFHDRFVQLLNAGGGSYASAEIANAQQNLLNAVNAPTQTLLGRPLVGDGADGASGPVGQPGGDGGILWGNGGNGGDSTSPGVAGGAGGSAGLIGNGGRGGNGAPGGAGGNGGLGGLLLGNGGAGGVGGTGDNGVGDLGAGGGGGDGGLGGRAGLIGHGGAGGNGGDGGHGGSGKAGGSGGSGGFGQFGGAGGLLYGNGGAAGSGGNGGDAGTGVSSDGFAGLGGSGGRGGDAGLIGVGGGGGNGGDPGLGARLFQVGSRGGDGGVGGWLYGDGGGGGDGGNGGLPFIGSTNAGNGGSARLIGNGGAGGSGGSGAPGSVSSGGVGGAGNPGGSGGNGGVWYGNGGAGGAAGQGGPGMNTTSPGGPGGVGGHGGTAILFGDGGAGGAGAAGGPGTPDGAAGPGGSGGTGGLLFGVPGPSGPDG
Uncharacterized PE-PGRS family protein PE_PGRS36
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
491
41,979
Reference proteome
null
Inferred from homology
2
null
null
null
PF00934;PF21526;
IPR000084;IPR048996;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
PE_PGRS36 MT2159 MTCY49.38c
false
Mycobacterium tuberculosis
389
row_392477
false
null
26,909
P9WKQ1
MDYAKRIGQVGALAVVLGVGAAVTTHAIGSAAPTDPSSSSTDSPVDACSPLGGSASSLAAIPGASVPQVGVRQVDPGSIPDDLLNALIDFLAAVRNGLVPIIENRTPVANPQQVSVPEGGTVGPVRFDACDPDGNRMTFAVRERGAPGGPQHGIVTVDQRTASFIYTADPGFVGTDTFSVNVSDDTSLHVHGLAGYLGPFHGHDDVATVTVFVGNTPTDTISGDFSMLTYNIAGLPFPLSSAILPRFFYTKEIGKRLNAYYVANVQEDFAYHQFLIKKSKMPSQTPPEPPTLLWPIGVPFSDGLNTLSEFKVQRLDRQTWYECTSDNCLTLKGFTYSQMRLPGGDTVDVYNLHTNTGGGPTTNANLAQVANYIQQNSAGRAVIVTGDFNARYSDDQSALLQFAQVNGLTDAWVQVEHGPTTPPFAPTCMVGNECELLDKIFYRSGQGVTLQAVSYGNEAPKFFNSKGEPLSDHSPAVVGFHYVADNVAVR
Sphingomyelinase (SMase) (EC 3.1.4.12)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
490
52,034
Cell outer membrane;Cytolysis;Hemolysis;Hydrolase;Ion transport;Lipid degradation;Lipid metabolism;Membrane;Porin;Reference proteome;Signal;Transmembrane;Transmembrane beta strand;Transport
GO:0006685; GO:0006811; GO:0009279; GO:0015288; GO:0022857; GO:0044002; GO:0044179; GO:0046930; GO:0055085; GO:0061751
Evidence at protein level
5
SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:26036301}; Multi-pass membrane protein {ECO:0000305|PubMed:26036301}.
SIGNAL 1..31; /evidence="ECO:0000255, ECO:0000305|PubMed:26036301"
TRANSMEM 137..145; /note="Beta stranded"; /evidence="ECO:0000255, ECO:0000305|PubMed:26036301"; TRANSMEM 162..168; /note="Beta stranded"; /evidence="ECO:0000255, ECO:0000305|PubMed:26036301"; TRANSMEM 172..182; /note="Beta stranded"; /evidence="ECO:0000255, ECO:0000305|PubMed:26036301"; TRANSMEM 188..196; /note="Beta stranded"; /evidence="ECO:0000255, ECO:0000305|PubMed:26036301"; TRANSMEM 205..213; /note="Beta stranded"; /evidence="ECO:0000255, ECO:0000305|PubMed:26036301"
PF17963;PF03372;
IPR036691;IPR005135;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
spmT Rv0888 MTCY31.16
false
Mycobacterium tuberculosis
390
row_23550
false
null
112,257
A1KMY6
MTATETVRVRFCPSPTGTPHVGLVRTALFNWAYARHTGGTFVFRIEDTDAQRDSEESYLALLDALRWLGLDWDEGPEVGGPYGPYRQSQRAEIYRDVLARLLAAGEAYHAFSTPEEVEARHVAAGRNPKLGYDNFDRHLTDAQRAAYLAEGRQPVVRLRMPDDDLAWNDLVRGPVTFAAGSVPDFALTRASGDPLYTLVNPCDDALMKITHVLRGEDLLPSTPRQLALHQALIRIGVAERIPKFAHLPTVLGEGTKKLSKRDPQSNLFAHRDRGFIPEGLLNYLALLGWSIADDHDLFGLDEMVAAFDVADVNSSPARFDQKKADALNAEHIRMLDVGDFTVRLRDHLDTHGHHIALDEAAFAAAAELVQTRIVVLGDAWELLKFFNDDQYVIDPKAAAKELGPDGAAVLDAALAALTSATDWTAPLIEAALKDALIEGLALKPRKAFSPIRVAATGTTVSPPLFESLELLGRDRSMQRLRAARQLVGHA
Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS)
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
410,289
490
53,836
Aminoacyl-tRNA synthetase;ATP-binding;Cytoplasm;Ligase;Nucleotide-binding;Protein biosynthesis
GO:0000049; GO:0004818; GO:0005524; GO:0005829; GO:0006424; GO:0008270
Inferred from homology
3
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00022}.
null
null
PF19269;PF00749;
IPR045462;IPR020751;IPR008925;IPR004527;IPR020752;IPR000924;IPR020058;IPR020061;IPR049940;IPR033910;IPR014729;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype), Mycobacterium tuberculosis variant bovis BCG (no rank)
gltX BCG_3013c
false
Mycobacterium tuberculosis
391
row_100722
false
null
26,972
P9WNF9
MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRESMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTGRQAIADGKPILEYVKSTAAMYGIDRHIRFHHKVISADWSTAENRWTVHIQSHGTLSALTCEFLFLCSGYYNYDEGYSPRFAGSEDFVGPIIHPQHWPEDLDYDAKNIVVIGSGATAVTLVPALADSGAKHVTMLQRSPTYIVSQPDRDGIAEKLNRWLPETMAYTAVRWKNVLRQAAVYSACQKWPRRMRKMFLSLIQRQLPEGYDVRKHFGPHYNPWDQRLCLVPNGDLFRAIRHGKVEVVTDTIERFTATGIRLNSGRELPADIIITATGLNLQLFGGATATIDGQQVDITTTMAYKGMMLSGIPNMAYTVGYTNASWTLKADLVSEFVCRLLNYMDDNGFDTVVVERPGSDVEERPFMEFTPGYVLRSLDELPKQGSRTPWRLNQNYLRDIRLIRRGKIDDEGLRFAKRPAPVGV
FAD-containing monooxygenase EthA (EC 1.14.13.-) (Baeyer-Villiger monooxygenase EtaA) (BVMO) (Prodrug activator EtaA)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
489
55,326
Cell membrane;FAD;Flavoprotein;Membrane;Monooxygenase;NADP;Oxidoreductase;Reference proteome
GO:0004499; GO:0005829; GO:0005886; GO:0006805; GO:0009274; GO:0016709; GO:0033776; GO:0050660; GO:0070402; GO:0071949
Evidence at protein level
5
SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:11823459}. Note=Is most likely membrane-associated. {ECO:0000303|PubMed:11823459}.
null
null
PF00743;PF13450;
IPR051820;IPR036188;IPR020946;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
ethA etaA Rv3854c
false
Mycobacterium tuberculosis
392
row_23612
false
null
207,340
P63714
MTATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTRRRASSGGIPVATSMWRDAQTVRTYGPAVAKALALRVAGKARSRLTGRHCRKFMQLTDFDPFDPAIAADPYPHYRELLAGERVQYNPKRDVYILSRYADVREAARNHDTLSSARGVTFSRGWLPFLPTSDPPAHTRMRKQLAPGMARGALETWRPMVDQLARELVGGLLTQTPADVVSTVAAPMPMRAITSVLGVDGPDEAAFCRLSNQAVRITDVALSASGLISLVQGFAGFRRLRALFTHRRDNGLLRECTVLGKLATHAEQGRLSDDELFFFAVLLLVAGYESTAHMISTLFLTLADYPDQLTLLAQQPDLIPSAIEEHLRFISPIQNICRTTRVDYSVGQAVIPAGSLVLLAWGAANRDPRQYEDPDVFRADRNPVGHLAFGSGIHLCPGTQLARMEGQAILREIVANIDRIEVVEPPTWTTNANLRGLTRLRVAVTPRVAP
Beta-dihydromenaquinone-9 omega-hydroxylase (EC 1.14.15.27) (Cytochrome P450 128)
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
233,413
489
53,313
Cytoplasm;Heme;Iron;Metal-binding;Monooxygenase;Oxidoreductase;Reference proteome
GO:0005506; GO:0005737; GO:0006707; GO:0008395; GO:0020037; GO:0036199
Inferred from homology
3
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P9WPN7}.
null
null
PF00067;
IPR001128;IPR002397;IPR017972;IPR036396;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype)
cyp128 BQ2027_MB2291C
false
Mycobacterium tuberculosis
393
row_193763
false
null
432,265
P9WQM8
MSAASQRVGAFGEEAGYHKGLKPRQLQMIGIGGAIGTGLFLGAGGRLAKAGPGLFLVYGVCGVFVFLILRALGELVLHRPSSGSFVSYAREFFGEKAAYAVGWMYFLHWAMTSIVDTTAIATYLQRWTIFTVVPQWILALIALTVVLSMNLISVEWFGELEFWAALIKVLALMAFLVVGTVFLAGRYPVDGHSTGLSLWNNHGGLFPTSWLPLLIVTSGVVFAYSAVELVGTAAGETAEPEKIMPRAINSVVARIAIFYVGSVALLALLLPYTAYKAGESPFVTFFSKIGFHGAGDLMNIVVLTAALSSLNAGLYSTGRVMHSIAMSGSAPRFTARMSKSGVPYGGIVLTAVITLFGVALNAFKPGEAFEIVLNMSALGIIAGWATIVLCQLRLHKLANAGIMQRPRFRMPFSPYSGYLTLLFLLVVLVTMASDKPIGTWTVATLIIVIPALTAGWYLVRKRVMAVARERLGHTGPFPAVANPPVRSRD
L-asparagine permease 1 (L-asparagine transport protein 1)
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
489
52,447
Amino-acid transport;Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix;Transport
GO:0005886; GO:0006865; GO:0055085
Inferred from homology
2
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
null
TRANSMEM 25..45; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 439..459; /note="Helical"; /evidence="ECO:0000255"
PF00324;
IPR004841;IPR004840;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
ansP1 ansP MT2186
false
Mycobacterium tuberculosis
394
row_414010
false
null
212,919
P9WN19
MADPGGFLKYTHRKLPKRRPVPLRLRDWREVYEEFDNESLRQQATRCMDCGIPFCHNGCPLGNLIPEWNDLVRRGRWRDAIERLHATNNFPDFTGRLCPAPCEPACVLGINQDPVTIKQIELEIIDKAFDEGWVQPRPPRKLTGQTVAVVGSGPAGLAAAQQLTRAGHTVTVFEREDRIGGLLRYGIPEFKMEKRHLDRRLDQMRSEGTEFRPGVNVGVDISAEKLRADFDAVVLAGGATAWRELPIPGRELEGVHQAMEFLPWANRVQEGDDVLDEDGQPPITAKGKKVVIIGGGDTGADCLGTVHRQGAIAVHQFEIMPRPPDARAESTPWPTYPLMYRVSAAHEEGGERVFSVNTEAFVGTDGRVSALRAHEVTMLDGKFVKVEGSDFELEADLVLLAMGFVGPERAGLLTDLGVKFTERGNVARGDDFDTSVPGVFVAGDMGRGQSLIVWAIAEGRAAAAAVDRYLMGSSALPAPVKPTAAPLQ
Glutamate synthase [NADPH] small chain (EC 1.4.1.13) (Glutamate synthase subunit beta) (GLTS beta chain)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
488
53,452
4Fe-4S;Amino-acid biosynthesis;Glutamate biosynthesis;Iron;Iron-sulfur;Metal-binding;NADP;Oxidoreductase;Reference proteome
GO:0004355; GO:0005829; GO:0005886; GO:0016639; GO:0046872; GO:0051539; GO:0097054
Evidence at protein level
3
null
null
null
PF14691;PF07992;
IPR028261;IPR036188;IPR023753;IPR006005;IPR051394;IPR009051;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
gltD Rv3858c
false
Mycobacterium tuberculosis
395
row_199121
false
null
432,247
P9WQI1
MRAEIGPDFRPHYTFGDAYPASERAHVNWELSAPVWHTAQMGSTTHREVAKLDRVPLPVEAARVAATGWQVTRTAVRFIGRLPRKGPWQQKVIKELPQTFADLGPTYVKFGQIIASSPGAFGESLSREFRGLLDRVPPAKTDEVHKLFVEELGDEPARLFASFEEEPFASASIAQVHYATLRSGEEVVVKIQRPGIRRRVAADLQILKRFAQTVELAKLGRRLSAQDVVADFADNLAEELDFRLEAQSMEAWVSHLHASPLGKNIRVPQVHWDFTTERVLTMERVHGIRIDNAAAIRKAGFDGVELVKALLFSVFEGGLRHGLFHGDLHAGNLYVDEAGRIVFFDFGIMGRIDPRTRWLLRELVYALLVKKDHAAAGKIVVLMGAVGTMKPETQAAKDLERFATPLTMQSLGDMSYADIGRQLSALADAYDVKLPRELVLIGKQFLYVERYMKLLAPRWQMMSDPQLTGYFANFMVEVSREHQSDIEV
Uncharacterized protein Rv0647c
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
488
54,824
Reference proteome
GO:0004672; GO:0005524; GO:0005829; GO:0005886; GO:0009274
Evidence at protein level
2
null
null
null
PF03109;
IPR004147;IPR011009;IPR000719;IPR050154;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
Rv0647c MTCY20H10.28c
false
Mycobacterium tuberculosis
396
row_413992
false
null
4,121
I6Y0R5
MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ
Dihydrofolate synthase/folylpolyglutamate synthase (DHFS / FPGS) (EC 6.3.2.12) (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (Tetrahydrofolylpolyglutamate synthase)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
487
50,779
3D-structure;Antibiotic resistance;ATP-binding;Folate biosynthesis;Ligase;Magnesium;Metal-binding;Nucleotide-binding;Reference proteome
GO:0004326; GO:0005524; GO:0005737; GO:0008841; GO:0009396; GO:0046654; GO:0046656; GO:0046677; GO:0046872
Evidence at protein level
5
null
null
null
PF02875;PF08245;
IPR001645;IPR018109;IPR036565;IPR004101;IPR036615;IPR013221;
2VOR;2VOS;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
folC Rv2447c
false
Mycobacterium tuberculosis
397
row_3270
false
null
213,243
P9WQM7
MPPLDITDERLTREDTGYHKGLHSRQLQMIALGGAIGTGLFLGAGGRLASAGPGLFLVYGICGIFVFLILRALGELVLHRPSSGSFVSYAREFYGEKVAFVAGWMYFLNWAMTGIVDTTAIAHYCHYWRAFQPIPQWTLALIALLVVLSMNLISVRLFGELEFWASLIKVIALVTFLIVGTVFLAGRYKIDGQETGVSLWSSHGGIVPTGLLPIVLVTSGVVFAYAAIELVGIAAGETAEPAKIMPRAINSVVLRIACFYVGSTVLLALLLPYTAYKEHVSPFVTFFSKIGIDAAGSVMNLVVLTAALSSLNAGLYSTGRILRSMAINGSGPRFTAPMSKTGVPYGGILLTAGIGLLGIILNAIKPSQAFEIVLHIAATGVIAAWATIVACQLRLHRMANAGQLQRPKFRMPLSPFSGYLTLAFLAGVLILMYFDEQHGPWMIAATVIGVPALIGGWYLVRNRVTAVAHHAIDHTKSVAVVHSADPI
L-asparagine permease 2 (L-asparagine transport protein 2)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
487
52,195
Amino-acid transport;Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix;Transport
GO:0005576; GO:0005886; GO:0006865; GO:0055085
Evidence at protein level
3
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
null
TRANSMEM 26..46; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 256..276; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 341..361; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 414..434; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 440..460; /note="Helical"; /evidence="ECO:0000255"
PF00324;
IPR004841;IPR004840;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
ansP2 Rv0346c MTCY13E10.06c
false
Mycobacterium tuberculosis
398
row_199441
false
null
431,469
P9WI40
MTSPHFAWLPPEINSALMFAGPGSGPLIAAATAWGELAEELLASIASLGSVTSELTSGAWLGPSAAAMMAVATQYLAWLSTAAAQAEQAAAQAMAIATAFEAALAATVQPAVVAANRGLMQLLAATNWFGQNAPALMDVEAAYEQMWALDVAAMAGYHFDASAAVAQLAPWQQVLRNLGIDIGKNGQINLGFGNTGSGNIGNNNIGNNNIGSGNTGTGNIGSGNTGSGNLGLGNLGDGNIGFGNTGSGNIGFGITGDHQMGFGGFNSGSGNIGFGNSGTGNVGLFNSGSGNIGIGNSGSLNSGIGTSGTINAGLGSAGSLNTSFWNAGMQNAALGSAAGSEAALVSSAGYATGGMSTAALSSGILASALGSTGGLQHGLANVLNSGLTNTPVAAPASAPVGGLDSGNPNPGSGSAAAGSGANPGLRSPGTSYPSFVNSGSNDSGLRNTAVREPSTPGSGIPKSNFYPSPDRESAYASPRIGQPVGSE
PPE family protein PPE10
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
487
47,247
Reference proteome;Secreted
GO:0005576; GO:0052572
Inferred from homology
2
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WI41}. Note=Secreted via the ESX-5 / type VII secretion system (T7SS). {ECO:0000250|UniProtKB:P9WI41}.
null
null
PF01469;PF00823;
IPR002989;IPR000030;IPR038332;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
PPE10 MT0458
false
Mycobacterium tuberculosis
399
row_413228
false
null
546,912
P9WLL4
MPRARWLQSAALMGALAVVLITAAPVAADAYQVPAPPSPTASCDVISPVAIPCVALGKFADAVAAECRRVGVPDARCVLPLAHRVTQAARDAYLQSWVHRTARFQDALQDPVPLRETQWLGTHNSFNSLSDSFTVSHADSNQQLSLAQQLDIDVRALELDLHYLPRLEGHGAPGVTVCHGLGPKNANLGCTVEPLLATVLPQIANWLNAPGHTEEVILLYLEDQLKNASAYESVVATLDQVLRRADGTSLIYRPNPARRATNGCVPLPLDVSREEIRASGARAVLVGSCAPGWSAAVFDWSGVELESGSNSGYRPYPACDATYGRGVYAWRLVRYYEDSTLATALANPTRPPANPQALTPPKVPAMTDCGVNLFGFDQLLPEDGRIQASLWSWAPDEPRAGAGACALQGADGRWVAASCGDPHPAACRDAAGRWTVTPAPVVFAGAALACTAIGADFTLPRTGNQNARLHAVAGPAGGAWVHYLLPP
Uncharacterized protein MT2135
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
487
51,580
Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix
GO:0005886; GO:0006629; GO:0008081
Predicted
1
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
null
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 45..65; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 439..459; /note="Helical"; /evidence="ECO:0000255"
null
IPR016187;IPR017946;IPR051008;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
MT2135
false
Mycobacterium tuberculosis
400
row_527004
false
null
67,946
O06581
MTRSNVLPVARTYSRTFSGARLRRLRQERGLTQVALAKALDLSTSYVNQLENDQRPITVPVLLLLTERFDLSAQYFSSDSDARLVADLSDVFTDIGVEHAVSGAQIEEFVARMPEVGHSLVAVHRRLRAATEELEGYRSRATAETELPPARPMPFEEVRDFFYDRNNYIHDLDMAAERMFTESGMRTGGLDIQLAELMRDRFGISVVIDDNLPDTAKRRYHPDTKVLRVAHWLMPGQRAFQIATQLALVGQSDLISSIVATDDQLSTEARGVARIGLANYFAGAFLLPYREFHRAAEQLRYDIDLLGRRFGVGFETVCHRLSTLQRPRQRGIPFIFVRTDKAGNISKRQSATAFHFSRVGGSCPLWVVHDAFAQPERIVRQVAQMPDGRSYFWVAKTTAADGLGYLGPHKNFAVGLGCDLAHAHKLVYSTGVVLDDPSTEVPIGAGCKICNRTSCAQRAFPYLGGRVAVDENAGSSLPYSSTEQSV
HTH-type transcriptional regulator PrpR (Propionate regulator) (PRPR)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
486
54,087
3D-structure;Activator;DNA-binding;Reference proteome;Repressor;Transcription;Transcription regulation
GO:0001666; GO:0003677; GO:0003700; GO:0006355; GO:0008203; GO:0019679
Evidence at protein level
4
null
null
null
PF01381;PF06114;PF09856;
IPR050807;IPR001387;IPR026281;IPR010359;IPR010982;IPR018653;
6CYJ;6CYY;6CZ6;6D2S;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
prpR Rv1129c RVBD_1129c P425_01178
false
Mycobacterium tuberculosis
401
row_59038
false
null
81,928
P9WPU5
MTTTAEKTDRPGKPGSSDTSGRVVRVTGPVVDVEFPRGSIPELFNALHAEITFESLAKTLTLEVAQHLGDNLVRTISLQPTDGLVRGVEVIDTGRSISVPVGEGVKGHVFNALGDCLDEPGYGEKFEHWSIHRKPPAFEELEPRTEMLETGLKVVDLLTPYVRGGKIALFGGAGVGKTVLIQEMINRIARNFGGTSVFAGVGERTREGNDLWVELAEANVLKDTALVFGQMDEPPGTRMRVALSALTMAEWFRDEQGQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGELQERITSTRGRSITSMQAVYVPADDYTDPAPATTFAHLDATTELSRAVFSKGIFPAVDPLASSSTILDPSVVGDEHYRVAQEVIRILQRYKDLQDIIAILGIDELSEEDKQLVNRARRIERFLSQNMMAAEQFTGQPGSTVPVKETIEAFDRLCKGDFDHVPEQAFFLIGGLDDLAKKAESLGAKL
ATP synthase subunit beta (EC 7.1.2.2) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
486
53,094
3D-structure;Acetylation;ATP synthesis;ATP-binding;Cell membrane;CF(1);Hydrogen ion transport;Ion transport;Membrane;Nucleotide-binding;Reference proteome;Translocase;Transport
GO:0005524; GO:0005576; GO:0005829; GO:0005886; GO:0009274; GO:0016887; GO:0045259; GO:0046933
Evidence at protein level
4
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01347}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01347}.
null
null
PF00006;PF02874;PF22919;
IPR003593;IPR055190;IPR005722;IPR020003;IPR050053;IPR004100;IPR036121;IPR000194;IPR024034;IPR027417;
8J0S;8J0T;8JR0;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
atpD Rv1310 MTCY373.30
false
Mycobacterium tuberculosis
402
row_72366
false
null
182,381
O06136
MVAAAGEPLNCQRANPEVTVKLPSADVVPRLRGRQRVVVHVDSRTARCVGALALVCAACWLIALLAGDYRHAQWAVAGRLGWSLTVLAAVAFIARGIFLGRPVTAMHATAAGLFLLAGLAAHVLVADLLGEILIAGSGWALMWPTSAHPRPEDLPRVWALINATRADSLAPFAMQAGKSHHFSAAGTAALAYRTRIGYAVVSGDPIGDEAQFPQLVADFAAMCHMHGWRIVVVGCSERRLGLWSDPMVVGQSLRPIPIGRDVVIDVSNFEMTGRRFRNLRQAVKRTHNFGVTTEIVAEQQLDDQRQAELAEVLAASPSGARTDRGFCMNLDGVLEGRYPGIQLIIARDASGRVQGFHRYATAGGGSDMSLDVPWRRRGAPNGIDERLSADMIAAAKDAGVQRLSLAFAAFPDLFGANQLGRLQRVCRALIHILDPLIALESLYRYLRKFHALDERRYVLISMTQVFALALVLLSLEFVPRRRHL
MprF-like domain protein Rv1619 (MtLysX2)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
484
52,642
Cell inner membrane;Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix
GO:0005886; GO:0016755; GO:0055091
Evidence at protein level
3
SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:35365094}; Multi-pass membrane protein {ECO:0000255}.
null
TRANSMEM 48..68; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 458..478; /note="Helical"; /evidence="ECO:0000255"
PF09924;
IPR024320;IPR051211;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
LysX2 Rv1619
false
Mycobacterium tuberculosis
403
row_169401
false
null
212,890
P9WMT0
MKGSSVPRFVDRVVIHTRAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDFHFRPHLTAASGKHGMGNNRDGAAGADLEVKVPEGTVVLDENGRLLADLVGAGTRFEAAAGGRGGLGNAALASRVRKAPGFALLGEKGQSRDLTLELKTVADVGLVGFPSAGKSSLVSAISAAKPKIADYPFTTLVPNLGVVSAGEHAFTVADVPGLIPGASRGRGLGLDFLRHIERCAVLVHVVDCATAEPGRDPISDIDALETELACYTPTLQGDAALGDLAARPRAVVLNKIDVPEARELAEFVRDDIAQRGWPVFCVSTATRENLQPLIFGLSQMISDYNAARPVAVPRRPVIRPIPVDDSGFTVEPDGHGGFVVSGARPERWIDQTNFDNDEAVGYLADRLARLGVEEELLRLGARSGCAVTIGEMTFDWEPQTPAGEPVAMSGRGTDPRLDSNKRVGAAERKAARSRRREHGDG
GTPase Obg (EC 3.6.5.-) (GTP-binding protein Obg)
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
484
50,920
Cytoplasm;GTP-binding;Hydrolase;Magnesium;Metal-binding;Nucleotide-binding;Reference proteome
GO:0000287; GO:0003924; GO:0005525; GO:0005737; GO:0042254
Inferred from homology
3
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01454}.
null
null
PF09269;PF01018;PF01926;
IPR031167;IPR006073;IPR014100;IPR036346;IPR006074;IPR006169;IPR036726;IPR045086;IPR015349;IPR027417;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
obg MT2516
false
Mycobacterium tuberculosis
404
row_199093
false
null
425,357
P63491
MVGASGSDAGAISGSGNQRLPTLTDLLYQLATRAVTSEELVRRSLRAIDVSQPTLNAFRVVLTESALADAAAADKRRAAGDTAPLLGIPIAVKDDVDVAGVPTAFGTQGYVAPATDDCEVVRRLKAAGAVIVGKTNTCELGQWPFTSGPGFGHTRNPWSRRHTPGGSSGGSAAAVAAGLVTAAIGSDGAGSIRIPAAWTHLVGIKPQRGRISTWPLPEAFNGVTVNGVLARTVEDAALVLDAASGNVEGDRHQPPPVTVSDFVGIAPGPLKIALSTHFPYTGFRAKLHPEILAATQRVGDQLELLGHTVVKGNPDYGLRLSWNFLARSTAGLWEWAERLGDEVTLDRRTVSNLRMGHVLSQAILRSARRHEAADQRRVGSIFDIVDVVLAPTTAQPPPMARAFDRLGSFGTDRAIIAACPSTWPWNLLGWPSINVPAGFTSDGLPIGVQLMGPANSEGMLISLAAELEAVSGWATKQPQVWWTS
Putative amidase AmiA2 (EC 3.5.1.4)
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
233,413
484
50,884
Hydrolase;Reference proteome
GO:0004040
Inferred from homology
2
null
null
null
PF01425;
IPR000120;IPR020556;IPR023631;IPR036928;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype)
amiA2 BQ2027_MB2384
false
Mycobacterium tuberculosis
405
row_407458
false
null
26,775
P9WH43
MPSPTVTSPQVAVNDIGSSEDFLAAIDKTIKYFNDGDIVEGTIVKVDRDEVLLDIGYKTEGVIPARELSIKHDVDPNEVVSVGDEVEALVLTKEDKEGRLILSKKRAQYERAWGTIEALKEKDEAVKGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYIGKEIEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLNNLQKGTIRKGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVQVGDEVTVEVLDVDMDRERVSLSLKATQEDPWRHFARTHAIGQIVPGKVTKLVPFGAFVRVEEGIEGLVHISELAERHVEVPDQVVAVGDDAMVKVIDIDLERRRISLSLKQANEDYTEEFDPAKYGMADSYDEQGNYIFPEGFDAETNEWLEGFEKQRAEWEARYAEAERRHKMHTAQMEKFAAAEAAGRGADDQSSASSAPSEKTAGGSLASDAQLAALREKLAGSA
Small ribosomal subunit protein bS1 (30S ribosomal protein S1)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
481
53,202
3D-structure;Reference proteome;Repeat;Ribonucleoprotein;Ribosomal protein;RNA-binding
GO:0003729; GO:0003735; GO:0005829; GO:0005886; GO:0006412; GO:0009274; GO:0022627
Evidence at protein level
5
null
null
null
PF00575;
IPR012340;IPR050437;IPR035104;IPR003029;
4NNG;4NNI;4NNK;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
rpsA Rv1630 MTCY01B2.22
false
Mycobacterium tuberculosis
406
row_23421
false
null
432,262
P9WQM4
MVGPRTRGYAIHKLGFCSVVMLGINSIIGAGIFLTPGEVIGLAGPFAPMAYVLAGIFAGVVAIVFATAARYVRTNGASYAYTTAAFGRRIGIYVGVTHAITASIAWGVLASFFVSTLLRVAFPDKAWADAEQLFSVKTLTFLGFIGVLLAINLFGNRAIKWANGTSTVGKAFALSAFIVGGLWIITTQHVNNYATAWSAYSATPYSLLGVAEIGKGTFSSMALATIVALYAFTGFESIANAAEEMDAPDRNLPRAIPIAIFSVGAIYLLTLTVAMLLGSNKIAASDDTVKLAAAIGNATFRTIIVVGALISMFGINVAASFGAPRLWTALADSGVLPTRLSRKNQYDVPMVSFAITASLALAFPLALRFDNLHLTGLAVIARFVQFIIVPIALIALARSQAVEHAAVRRNAFTDKVLPLVAIVVSVGLAVSYDYRCIFLVRGGPNYFSIALIVITFIVVPAMAYLHYYRIIRRVGDRPSTR
Uncharacterized transporter MT2031
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
481
51,116
Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix;Transport
GO:0005886; GO:0022857
Inferred from homology
2
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
null
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 46..66; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 134..154; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 411..431; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..466; /note="Helical"; /evidence="ECO:0000255"
PF13520;
IPR002293;IPR050367;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
MT2031
false
Mycobacterium tuberculosis
407
row_414007
false
null
26,983
P9WNR7
MGLRLTTKVQVSGWRFLLRRLEHAIVRRDTRMFDDPLQFYSRSIALGIVVAVLILAGAALLAYFKPQGKLGGTSLFTDRATNQLYVLLSGQLHPVYNLTSARLVLGNPANPATVKSSELSKLPMGQTVGIPGAPYATPVSAGSTSIWTLCDTVARADSTSPVVQTAVIAMPLEIDASIDPLQSHEAVLVSYQGETWIVTTKGRHAIDLTDRALTSSMGIPVTARPTPISEGMFNALPDMGPWQLPPIPAAGAPNSLGLPDDLVIGSVFQIHTDKGPQYYVVLPDGIAQVNATTAAALRATQAHGLVAPPAMVPSLVVRIAERVYPSPLPDEPLKIVSRPQDPALCWSWQRSAGDQSPQSTVLSGRHLPISPSAMNMGIKQIHGTATVYLDGGKFVALQSPDPRYTESMYYIDPQGVRYGVPNAETAKSLGLSSPQNAPWEIVRLLVDGPVLSKDAALLEHDTLPADPSPRKVPAGASGAP
ESX-1 secretion system ATPase EccB1 (EC 3.6.-.-) (ESX conserved component B1) (Type VII secretion system protein EccB1) (T7SS protein EccB1)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
480
51,093
3D-structure;ATP-binding;Cell inner membrane;Cell membrane;Disulfide bond;Hydrolase;Membrane;Nucleotide-binding;Reference proteome;Repeat;Transmembrane;Transmembrane helix;Transport
GO:0005524; GO:0005576; GO:0005886; GO:0009274; GO:0016787; GO:0052167
Evidence at protein level
5
SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:26396239}; Single-pass membrane protein {ECO:0000255}. Note=Resides at or near the cell wall, the protein is susceptible to extracellular proteases (PubMed:26396239). {ECO:0000269|PubMed:26396239}.
null
TRANSMEM 44..64; /note="Helical"; /evidence="ECO:0000255"
PF05108;
IPR007795;IPR044857;IPR042485;
3X3M;3X3N;4KK7;5EBC;5EBD;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
eccB1 Rv3869
false
Mycobacterium tuberculosis
408
row_23622
false
null
81,712
P9WHJ9
MANARSQYRCSECRHVSAKWVGRCLECGRWGTVDEVAVLSAVGGTRRRSVAPASGAVPISAVDAHRTRPCPTGIDELDRVLGGGIVPGSVTLLAGDPGVGKSTLLLEVAHRWAQSGRRALYVSGEESAGQIRLRADRIGCGTEVEEIYLAAQSDVHTVLDQIETVQPALVIVDSVQTMSTSEADGVTGGVTQVRAVTAALTAAAKANEVALILVGHVTKDGAIAGPRSLEHLVDVVLHFEGDRNGALRMVRGVKNRFGAADEVGCFLLHDNGIDGIVDPSNLFLDQRPTPVAGTAITVTLDGKRPLVGEVQALLATPCGGSPRRAVSGIHQARAAMIAAVLEKHARLAIAVNDIYLSTVGGMRLTEPSADLAVAIALASAYANLPLPTTAVMIGEVGLAGDIRRVNGMARRLSEAARQGFTIALVPPSDDPVPPGMHALRASTIVAALQYMVDIADHRGTTLATPPSHSGTGHVPLGRGT
DNA repair protein RadA (EC 3.6.4.-) (Branch migration protein RadA) (DNA repair protein Sms)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
480
49,913
ATP-binding;DNA damage;DNA repair;DNA-binding;Hydrolase;Metal-binding;Nucleotide-binding;Reference proteome;Stress response;Zinc;Zinc-finger
GO:0000725; GO:0003684; GO:0005524; GO:0005829; GO:0008270; GO:0016887; GO:0140664
Evidence at protein level
4
null
null
null
PF13481;PF13541;PF18073;
IPR003593;IPR004504;IPR027417;IPR020588;IPR020568;IPR014721;IPR041166;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
radA Rv3585 MTV024.03
false
Mycobacterium tuberculosis
409
row_72160
false
null
81,852
P9WMY7
MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDPRRVALLAVHTSPLAQPGTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPVVRVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDIVHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRTVGEQQVVDEADRLIVNTDDEARQVISLHGADPARIDVVHPGVDLDVFRPGDRRAARAALGLPVDERVVAFVGRIQPLKAPDIVLRAAAKLPGVRIIVAGGPSGSGLASPDGLVRLADELGISARVTFLPPQSHTDLATLFRAADLVAVPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGITGTLVSGHEVGQWADAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLASYRRAIGEYNAERQRRGGEVISDLVAVGKPRHWTPRRGVGA
D-inositol 3-phosphate glycosyltransferase (EC 2.4.1.250) (N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase) (GlcNAc-Ins-P N-acetylglucosaminyltransferase)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
480
50,541
Glycosyltransferase;Magnesium;Metal-binding;Reference proteome;Transferase
GO:0000287; GO:0005829; GO:0008375; GO:0010125; GO:0016757; GO:0102710
Evidence at protein level
4
null
null
null
PF13579;PF00534;
IPR001296;IPR028098;IPR017814;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
mshA Rv0486 MTCY20G9.12
false
Mycobacterium tuberculosis
410
row_72296
false
null
81,817
P9WKI3
MMRFLDGHPPGYDLTYNDVFIVPNRSEVASRFDVDLSTADGSGTTIPVVVANMTAVAGRRMAETVARRGGIVILPQDLPIPAVKQTVAFVKSRDLVLDTPVTLAPDDSVSDAMALIHKRAHGVAVVILEGRPIGLVRESSCLGVDRFTRVRDIAVTDYVTAPAGTEPRKIFDLLEHAPVDVAVLTDADGTLAGVLSRTGAIRAGIYTPATDSAGRLRIGAAVGINGDVGAKARALAEAGVDVLVIDTAHGHQVKTLDAIKAVSALDLGLPLAAGNVVSAEGTRDLLKAGANVVKVGVGPGAMCTTRMMTGVGRPQFSAVLECASAARQLGGHIWADGGIRHPRDVALALAAGASNVMIGSWFAGTYESPGDLMRDRDDQPYKESYGMASKRAVVARTGADNPFDRARKALFEEGISTSRMGLDPDRGGVEDLIDHITSGVRSTCTYVGASNLAELHERAVVGVQSGAGFAEGHPLPAGW
GMP reductase (EC 1.7.1.7) (Guanosine 5'-monophosphate reductase) (GMPR)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
479
49,965
CBS domain;NADP;Oxidoreductase;Purine salvage;Reference proteome;Repeat
GO:0003920; GO:0005829; GO:0005886; GO:0006166; GO:0032264
Evidence at protein level
4
null
null
null
PF00571;PF00478;
IPR013785;IPR000644;IPR046342;IPR050139;IPR005991;IPR005990;IPR001093;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
guaB1 Rv1843c MTCY1A11.01 MTCY359.30
false
Mycobacterium tuberculosis
411
row_72263
false
null
431,441
P9WHX4
MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFESVCSGLADRWWQGPSSRMMAAQAARHTGWLAAAATQAEGAASQAQTMALAYEAAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWAQDVVAMLNYHAVASAVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPSSTTTRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEVVSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQPVTVAGLSMGSMVIDRELAYLAIDPNAPPSSALTFVELAGPERGLAQTYLPVGTTIPIAGYTVGNAPESQYNTSVVYSQYDIWADPPDRPWNLLAGANALMGAAYFHDLTAYAAPQQGIEIAAVTSSLGGTTTTYMIPSPTLPLLLPLKQIGVPDWIVGGLNNVLKPLVDAGYSQYAPTAGPYFSHGNLVW
Uncharacterized PPE family protein PPE63
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
479
49,970
Reference proteome
GO:0052572
Inferred from homology
2
null
null
null
PF08237;PF00823;
IPR029058;IPR013228;IPR000030;IPR038332;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
PPE63 MT3643
false
Mycobacterium tuberculosis
412
row_413200
false
null
546,594
P9WJ96
MTSLIDYILSLFRSEDAARSFVAAPGRAMTSAGLIDIAPHQISSVAANVVPGLNLGAGDPMSGLRQAVAARHGFAQDVANVGFAGDAGAGVASVITTDVGAGLASGLGAGFLGQGGLALAASSGGFGGQVGLAAQVGLGFTAVIEAEVGAQVGAGLGIGTGLGAQAGMGFGGGVGLGLGGQAGGVIGGSAAGAIGAGVGGRVGGNGQIGVAGQGAVGAGVGAGVGGQAGIASQIGVSAGGGLGGVGNVSGLTGVSSNACLASNASGQAGLIASEGAALNGAAMPHLSGPLAGVGVGGQAGAAGGAGLGFGAVGHPTPQPAALGAAGVVAKTEAAAGVVGGVGGATAAGVGGAHGDILGHEGAALGSVDTVNAGVTPVEHGLVLPSGPLIHGGTGGYGGMNPPVTDAPAPQVPARAQPMTTAAEHTPAVTQPQHTPVEPPVHDKPPSHSVFDVGHEPPVTHTPPAPIELPSYGLFGLPGF
Isoniazid-induced protein IniB
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
479
43,911
Reference proteome
null
Predicted
1
null
null
null
null
IPR049709;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
iniB MT0356
false
Mycobacterium tuberculosis
413
row_526687
false
null
26,955
P9WN39
MTEKTPDDVFKLAKDEKVEYVDVRFCDLPGIMQHFTIPASAFDKSVFDDGLAFDGSSIRGFQSIHESDMLLLPDPETARIDPFRAAKTLNINFFVHDPFTLEPYSRDPRNIARKAENYLISTGIADTAYFGAEAEFYIFDSVSFDSRANGSFYEVDAISGWWNTGAATEADGSPNRGYKVRHKGGYFPVAPNDQYVDLRDKMLTNLINSGFILEKGHHEVGSGGQAEINYQFNSLLHAADDMQLYKYIIKNTAWQNGKTVTFMPKPLFGDNGSGMHCHQSLWKDGAPLMYDETGYAGLSDTARHYIGGLLHHAPSLLAFTNPTVNSYKRLVPGYEAPINLVYSQRNRSACVRIPITGSNPKAKRLEFRSPDSSGNPYLAFSAMLMAGLDGIKNKIEPQAPVDKDLYELPPEEAASIPQTPTQLSDVIDRLEADHEYLTEGGVFTNDLIETWISFKRENEIEPVNIRPHPYEFALYYDV
Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Glutamine synthetase I beta) (GSI beta)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
478
53,570
3D-structure;ATP-binding;Cytoplasm;Direct protein sequencing;Ligase;Magnesium;Metal-binding;Nucleotide-binding;Phosphoprotein;Reference proteome;Virulence
GO:0000287; GO:0001968; GO:0004356; GO:0005524; GO:0005576; GO:0005737; GO:0005829; GO:0005886; GO:0006542; GO:0009274; GO:0010756; GO:0016020; GO:0019740; GO:0035375; GO:0051260
Evidence at protein level
5
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:9278431}.
null
null
PF00120;PF03951;
IPR008147;IPR036651;IPR014746;IPR008146;IPR027303;IPR004809;IPR001637;IPR027302;
1HTO;1HTQ;2BVC;2WGS;2WHI;3ZXR;3ZXV;4ACF;4XYC;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
glnA1 glnA Rv2220 MTCY190.31 MTCY427.01
false
Mycobacterium tuberculosis
414
row_23595
false
null
425,366
P63520
MDQFPIMGVPDGGDTAWMLVSSALVLLMTPGLAFFYGGMVRSKSVLNMIMMSISAMGVVTVLWALYGYSIAFGDDVGNIAGNPSQYWGLKGLIGVNAVAADPSTQTAAVNIPLAGTLPATVFVAFQLMFAIITVALISGAVADRLKFGAWLLFAGLWATFVYFPVAHWVFAFDGFAAEHGGWIANKLHAIDFAGGTAVHINAGVAALMLAIVLGKRRGWPATLFRPHNLPFVMLGAALLWFGWYGFNAGSATTANGVAGATFVTTTIATAAAMLGWLLTERVRDGKATTLGAASGIVAGLVAITPSCSSVNVLGALAVGVSAGVLCALAVGLKFKLGFDDSLDVVGVHLVGGLVGTLLVGLLAAPEAPAINGVAGVSKGLFYGGGFAQLERQALGACSVLVYSGIITLILALILKFTIGLRLDAEQESTGIDEAEHAESGYDFAVASGSVLPPRVTVEDSRNGIQERIGQKVEAEPK
Ammonium transporter (Ammonia channel) (Ammonium channel)
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
233,413
477
49,241
Ammonia transport;Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix;Transport
GO:0005886; GO:0008519
Inferred from homology
2
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
null
TRANSMEM 16..36; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 121..141; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 229..249; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 312..332; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 394..414; /note="Helical"; /evidence="ECO:0000255"
PF00909;
IPR029020;IPR001905;IPR018047;IPR024041;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype)
amt BQ2027_MB2944C
false
Mycobacterium tuberculosis
415
row_407467
false
null
26,811
P9WI75
MPLAEGSTFAGFTIVRQLGSGGMGEVYLARHPRLPRQDALKVLRADVSADGEYRARFNREADAAASLWHPHIVAVHDRGEFDGQLWIDMDFVDGTDTVSLLRDRYPNGMPGPEVTEIITAVAEALDYAHERRLLHRDVKPANILIANPDSPDRRIMLADFGIAGWVDDPSGLTATNMTVGTVSYAAPEQLMGNELDGRADQYALAATAFHLLTGSPPFQHANPAVVISQHLSASPPAIGDRVPELTPLDPVFAKALAKQPKDRYQRCVDFARALGHRLGGAGDPDDTRVSQPVAVAAPAKRSLLRTAVIVPAVLAMLLVMAVAVAVREFQRADDERAAQPARTRTTTSAGTTTSVAPASTTRPAPTTPTTTGAADTATASPTAAVVAIGALCFPLGSTGTTKTGATAYCSTLQGTNTTIWSLTEDTVASPTVTATADPTEAPLPIEQESPIRVCMQQTGQTRRECREEIRRSNGWP
Serine/threonine-protein kinase PknF (EC 2.7.11.1)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
476
50,668
3D-structure;ATP-binding;Cell membrane;Kinase;Membrane;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase;Transmembrane;Transmembrane helix
GO:0000921; GO:0001558; GO:0004672; GO:0004674; GO:0005524; GO:0005829; GO:0005886; GO:0010827; GO:0051055; GO:0106310
Evidence at protein level
5
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11496007}; Single-pass membrane protein {ECO:0000269|PubMed:11496007}.
null
TRANSMEM 306..326; /note="Helical"; /evidence="ECO:0000255"
PF00069;
IPR011009;IPR000719;IPR008271;
7NAA;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
pknF Rv1746 MTCY28.09
false
Mycobacterium tuberculosis
416
row_23456
false
null
432,151
P9WPM4
MVLRSLASPAALTDPKRCASVVGVAAFAVRREHAPDALGGPPGLPAPRGFRAAFAAAYAVAYLAGGERRMLRLIRRYGPIMTMPILSLGDVAIVSDSALAKEVFTAPTDVLLGGEGVGPAAAIYGSGSMFVQEEPEHLRRRKLLTPPLHGAALDRYVPIIENSTRAAMHTWPVDRPFAMLTVARSLMLDVIVKVIFGVDDPEEVRRLGRPFERLLNLGVSEQLTVRYALRRLGALRVWPARARANTEIDDVVMALIAQRRADPRLGERHDVLSLLVSARGESGEQLSDSEIRDDLITLVLAGHETTATTLAWAFDLLLHHPDALRRVRAEAVGGGEAFTTAVINETLRVRPPAPLTARVAAQPLTIGGYRVEAGTRIVVHIIAINRSAEVYEHPHEFRPERFLGTRPQTYAWVPFGGGVKRCLGANFSMRELITVLHVLLREGEFTAVDDEPERIVRRSIMLVPRRGTRVRFRPAR
Putative cytochrome P450 137 (EC 1.14.-.-)
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
476
52,266
Heme;Iron;Metal-binding;Monooxygenase;Oxidoreductase;Reference proteome
GO:0004497; GO:0005506; GO:0016705; GO:0020037
Inferred from homology
2
null
null
null
PF00067;
IPR001128;IPR017972;IPR002401;IPR036396;IPR050121;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
cyp137 MT3787
false
Mycobacterium tuberculosis
417
row_413896
false
null
7,285
O69729
MGITAATEMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRHETHNYIRSGPGPRFLDAPGQPAGMVAAVVSDGTTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRVLAAPSRNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATTAGIVIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPDANPSTEVGQLGSALNRMLDHIAAALSARQASETCVRQFVADASHELRTPLAAIRGYTELTQRIGDDPEAVAHAMSRVASETERITRLVEDLLLLARLDSGRPLERGPVDMSRLAVDAVSDAHVAGPDHQWALDLPPEPVVIPGDAARLHQVVTNLLANARVHTGPGTIVTTRLSTGPTHVVLQVIDNGPGIPAALQSEVFERFARGDTSRSRQAGSTGLGLAIVSAVVKAHNGTITVSSSPGYTEFAVRLPLDGWQPLESSPR
Probable sensor histidine kinase TcrY (EC 2.7.13.3)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
475
50,344
ATP-binding;Cell membrane;Kinase;Membrane;Nucleotide-binding;Phosphoprotein;Reference proteome;Transferase;Transmembrane;Transmembrane helix;Two-component regulatory system
GO:0000155; GO:0000160; GO:0000287; GO:0005509; GO:0005524; GO:0005829; GO:0005886; GO:0042803
Evidence at protein level
5
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
null
TRANSMEM 154..174; /note="Helical"; /evidence="ECO:0000255"
PF00672;PF02518;PF00512;
IPR003660;IPR036890;IPR005467;IPR003661;IPR036097;IPR004358;IPR050428;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
tcrY Rv3764c
false
Mycobacterium tuberculosis
418
row_6023
false
null
425,360
P63497
MTDADSAVPPRLDEDAISKLELTEVADLIRTRQLTSAEVTESTLRRIERLDPQLKSYAFVMPETALAAARAADADIARGHYEGVLHGVPIGVKDLCYTVDAPTAAGTTIFRDFRPAYDATVVARLRAAGAVIIGKLAMTEGAYLGYHPSLPTPVNPWDPTAWAGVSSSGCGVATAAGLCFGSIGSDTGGSIRFPTSMCGVTGIKPTWGRVSRHGVVELAASYDHVGPITRSAHDAAVLLSVIAGSDIHDPSCSAEPVPDYAADLALTRIPRVGVDWSQTTSFDEDTTAMLADVVKTLDDIGWPVIDVKLPALAPMVAAFGKMRAVETAIAHADTYPARADEYGPIMRAMIDAGHRLAAVEYQTLTERRLEFTRSLRRVFHDVDILLMPSAGIASPTLETMRGLGQDPELTARLAMPTAPFNVSGNPAICLPAGTTARGTPLGVQFIGREFDEHLLVRAGHAFQQVTGYHRRRPPV
Putative amidase AmiD (EC 3.5.1.4)
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
233,413
475
50,646
Hydrolase;Reference proteome
GO:0004040
Inferred from homology
2
null
null
null
PF01425;
IPR000120;IPR020556;IPR023631;IPR036928;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype)
amiD BQ2027_MB3409
false
Mycobacterium tuberculosis
419
row_407461
false
null
26,889
P9WKC3
MTRINPIDLSFLLLERANRPNHMAAYTIFEKPKGQKSSFGPRLFDAYRHSQAAKPFNHKLKWLGTDVAAWETVEPDMGYHIRHLALPAPGSMQQFHETVSFLNTGLLDRGHPMWECYIIDGIERGRIAILLKVHHALIDGEGGLRAMRNFLSDSPDDTTLAGPWMSAQGADRPRRTPATVSRRAQLQGQLQGMIKGLTKLPSGLFGVSADAADLGAQALSLKARKASLPFTARRTLFNNTAKSAARAYGNVELPLADVKALAKATGTSVNDVVMTVIDDALHHYLAEHQASTDRPLVAFMPMSLREKSGEGGGNRVSAELVPMGAPKASPVERLKEINAATTRAKDKGRGMQTTSRQAYALLLLGSLTVADALPLLGKLPSANVVISNMKGPTEQLYLAGAPLVAFSGLPIVPPGAGLNVTFASINTALCIAIGAAPEAVHEPSRLAELMQRAFTELQTEAGTTSPTTSKSRTP
Probable diacyglycerol O-acyltransferase Tgs4 (TGS4) (EC 2.3.1.20) (Probable triacylglycerol synthase tgs4)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
474
50,887
Acyltransferase;Glycerol metabolism;Lipid biosynthesis;Lipid metabolism;Reference proteome;Transferase
GO:0001666; GO:0004144; GO:0005886; GO:0006071; GO:0008374; GO:0010447; GO:0019432; GO:0045017; GO:0051701; GO:0071731
Evidence at protein level
5
null
null
null
PF06974;PF03007;
IPR014292;IPR045034;IPR009721;IPR004255;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
tgs4 Rv3088 MTV013.09
false
Mycobacterium tuberculosis
420
row_23530
false
null
26,960
P9WN93
MAVDADSANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQLDSDRL
Fumarate hydratase class II (Fumarase C) (EC 4.2.1.2) (Aerobic fumarase) (Iron-independent fumarase)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
474
50,141
3D-structure;Acetylation;Cytoplasm;Lyase;Reference proteome;Tricarboxylic acid cycle
GO:0004333; GO:0005576; GO:0005829; GO:0005886; GO:0006099; GO:0006106; GO:0009274
Evidence at protein level
5
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000305}.
null
null
PF10415;PF00206;
IPR005677;IPR024083;IPR018951;IPR020557;IPR000362;IPR022761;IPR008948;
3NO9;4ADL;4ADM;4APA;4APB;5F91;5F92;6S43;6S7K;6S7S;6S7U;6S7W;6S7Z;6S88;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
fumC fum Rv1098c MTV017.51c
false
Mycobacterium tuberculosis
421
row_23600
false
null
81,835
P9WMI1
MSKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLNQIEHDVRPLTVAVLLRITEVFGVDATFFASQDDTRLVAELREVTLDRDLDIAIDPHEVAEMVSAHPGLACAVVNLHRRYRITTAQLAAATEERFSDGSGRGSITMPHEEVRDYFYQRQNYLHALDTAAEDLTAQMRMHHGDLARELTRRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLSPGQQVFKMAAELAYLEFGDLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFHDVAENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVPFTFVRVDRAGNMSKRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVARTVELRAARYGQPGKTFAIGLGCELRHAHRLVYSEGLDLSGDPNTAATPIGAGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQL
HTH-type transcriptional regulator RamB (icl1 and ramB operon repressor protein)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
474
53,072
DNA-binding;Reference proteome;Repressor;Transcription;Transcription regulation
GO:0001666; GO:0003677; GO:0003700; GO:0005886; GO:0006355
Evidence at protein level
4
null
null
null
PF01381;PF06114;PF09856;
IPR050807;IPR001387;IPR026281;IPR010359;IPR010982;IPR018653;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
ramB Rv0465c
false
Mycobacterium tuberculosis
422
row_72281
false
null
402,942
O05897
MTGRVGNPKDHAVVIGASIAGLCAARVLSDFYSTVTVFERDELPEAPANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENRPDCIYLGAAGHVLGTGHTLRKEFTAYVPSRPHLEWQLRRRVLQLSNVQIVRRLVTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAAGRGTRLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGASHDQSLGLGMLCYEDGTWVLTTFGVADAKPPPTFDEMRALADKLLPARFTAALAQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGMTMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDISFHHATAEPLPRWWRPAGSLFDQFLGAAETDPVLAEWFLRRFSLLDSLYMVPSVPIIGRAIAHNLRLWLKEQRERRQPVTTRRSP
Protein Rv3254
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
474
52,783
Direct protein sequencing;Reference proteome
GO:0005506; GO:0005829; GO:0005886; GO:0009274; GO:0052837
Evidence at protein level
2
null
null
null
null
IPR036188;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
Rv3254 RVBD_3254 P425_03394
false
Mycobacterium tuberculosis
423
row_385477
false
null
27,077
P9WQH5
MTIMAPEAVGESLDPRDPLLRLSNFFDDGSVELLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGVEGCTHIVNAYDTAIEDQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVADDELDAYDRGRRLVGLFCQQGHFDRSKAEAGDTDIHALLPESSRRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQLAAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL
Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta6 subunit (Acetyl-CoA carboxylase) (ACC) (EC 2.1.3.15) (Propionyl-CoA carboxylase) (PCC) (EC 2.1.3.-)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
473
50,136
3D-structure;Acetylation;Fatty acid biosynthesis;Fatty acid metabolism;Lipid biosynthesis;Lipid metabolism;Reference proteome;Transferase
GO:0003989; GO:0004658; GO:0009274; GO:0009317; GO:0016740; GO:0019367
Evidence at protein level
5
null
null
null
PF01039;
IPR051047;IPR034733;IPR029045;IPR011763;IPR011762;
4FB8;4G2R;4L6W;6P7U;6PK2;6PRW;6TZV;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
accD6 Rv2247 MTCY427.28
false
Mycobacterium tuberculosis
424
row_23710
false
null
81,652
P9WF10
MRHYYSVDTIRAAEAPLLASLPDGALMRRAAFGLATEIGRELTARTGGVVGRRVCAVVGSGDNGGDALWAATFLRRRGAAADAVLLNPDRTHRKALAAFTKSGGRLVESVSAATDLVIDGVVGISGSGPLRPAAAQVFAAVQAAAIPVVAVDIPSGIDVATGAITGPAVHAALTVTFGGLKPVHALADCGRVVLVDIGLDLAHTDVLGFEATDVAARWPVPGPRDDKYTQGVTGVLAGSSTYPGAAVLCTGAAVAATSGMVRYAGTAHAEVLAHWPEVIASPTPAAAGRVQAWVVGPGLGTDEAGAAALWFALDTDLPVLVDADGLTMLADHPDLVAGRNAPTVLTPHAGEFARLAGAPPGDDRVGACRQLADALGATVLLKGNVTVIADPGGPVYLNPAGQSWAATAGSGDVLSGMIGALLASGLPSGEAAAAAAFVHARASAAAAADPGPGDAPTSASRISGHIRAALAAL
Bifunctional NAD(P)H-hydrate repair enzyme Nnr (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
83,331
473
46,857
ATP-binding;Isomerase;Lyase;Metal-binding;Multifunctional enzyme;NAD;NADP;Nucleotide-binding;Potassium;Reference proteome
GO:0005524; GO:0046496; GO:0046872; GO:0052855; GO:0052856; GO:0110051
Inferred from homology
4
null
null
null
PF01256;PF03853;
IPR017953;IPR000631;IPR030677;IPR029056;IPR004443;IPR036652;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
nnr MT3539
false
Mycobacterium tuberculosis
425
row_72102
false
null
94,033
Q79FH3
MTFPMWFAVPPEVPSAWLSTGMGPGPLLAAARAWHALAAQYTEIATELASVLAAVQASSWQGPSADRFVVAHQPFRYWLTHAATVATAAAAAHETAAAGYTSALGGMPTLAELAANHAMHGALVTTNFFGVNTIPIALNEADYLRMWIQAATVMSHYQAVAHESVAATPSTPPAPQIVTSAASSAASSSFPDPTKLILQLLKDFLELLRYLAVELLPGPLGDLIAQVLDWFISFVSGPVFTFLAYLVLDPLIYFGPFAPLTSPVLLPAGLTGLAGLGAVSGPAGPMVERVHSDGPSRQSWPAATGVTLVGTNPAALVTTPAPAPTTSAAPTAPSTPGSSAAQGLYAVGGPDGEGFNPIAKTTALAGVTTDAAAPAAKLPGDQAQSSASKATRLRRRLRQHRFEFLADDGRLTMPNTPEMADVAAGNRGLDALGFAGTIPKSAPGSATGLTHLGGGFADVLSQPMLPHTWDGSD
PPE family protein PPE37 (Heme-iron acquisition protein PPE37)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
473
48,563
Cell membrane;Iron;Membrane;Metal-binding;Reference proteome;Transmembrane;Transmembrane helix
GO:0052572; GO:0075139
Evidence at protein level
4
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29362230}; Multi-pass membrane protein {ECO:0000255}. Note=In vitro, the N- and C-terminal segments transfected into the human monocytic THP-1 cells are localized to the cytoplasm and nucleus of THP-1 cells, respectively. {ECO:0000269|PubMed:29362230}.
null
TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical"; /evidence="ECO:0000255"
PF00823;PF18878;
IPR043641;IPR000030;IPR038332;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
PPE37 Rv2123
false
Mycobacterium tuberculosis
426
row_83529
false
null
112,256
A1KMY2
MALQTGEPRTLAEKIWDDHIVVSGGGCAPDLIYIDLHLVHEVTSPQAFDGLRLAGRRVRRPELTLATEDHNVPTVDIDQPIADPVSRTQVETLRRNCAEFGIRLHSMGDIEQGIVHVVGPQLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGRLPDGVSAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDETTYAFLRGRPHAPTGAQWDTALVYWQRLRTDVGAVFDTEVYLDAASLSPFVTWGTNPGQGVPLAAAVPDPQLMTDDAERQAAEKALAYMDLRPGTAMREIAVDAVFVGSCTNGRIEDLRVVAEVLRGRKVADGVRMLIVPGSMRVRAQAEAEGLGEIFTDAGAQWRQAGCSMCLGMNPDQLASGERCAATSNRNFEGRQGAGGRTHLVSPAVAAATAVRGTLSSPADLN
3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase)
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
410,289
473
50,199
4Fe-4S;Amino-acid biosynthesis;Branched-chain amino acid biosynthesis;Iron;Iron-sulfur;Leucine biosynthesis;Lyase;Metal-binding
GO:0003861; GO:0009098; GO:0046872; GO:0051539
Inferred from homology
3
null
null
null
PF00330;
IPR004430;IPR015931;IPR001030;IPR018136;IPR036008;IPR050067;IPR033941;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype), Mycobacterium tuberculosis variant bovis BCG (no rank)
leuC BCG_3009c
false
Mycobacterium tuberculosis
427
row_100721
false
null
425,359
P63495
MSRVHAFVDDALGDLDAVALADAIRSGRVGRADVVEAAIARAEAVNPALNALAYAAFDVARDAAAMGTGQEAFFSGVPTFIKDNVDVAGQPSMHGTDAWEPYAAVADSEITRVVLGTGLVSLGKTQLSEFGFSAVAEHPRLGPVRNPWNTDYTAGASSSGSGALVAAGVVPIAHANDGGGSIRIPAACNGLVGLKPSRGRLPLEPEYRRLPVGIVANGVLTRTVRDTAAFYREAERLWRNHQLPPVGDVTSPVKQRLRIAVVTRSVLREASPEVRQLTLKLAGLLEELGHRVEHVDHPPAPASFVDDFVLYWGFLALAQVRSGRRTFGRTFDPTRLDELTLGLARHTGRNLHRLPLAIMRLRMLRRRSVRFFGTYDVLLTPTVAEATPQVGYLAPTDYQTVLDRLSSWVVFTPVQNVTGVPAISLPLAQSADGMPVGMMLSADTGREALLLELAYELEEARPWARIHAPNIAE
Putative amidase AmiC (EC 3.5.1.4)
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
233,413
473
50,916
Hydrolase;Reference proteome
GO:0004040
Inferred from homology
2
null
null
null
PF01425;
IPR000120;IPR020556;IPR023631;IPR036928;
null
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species), Mycobacterium bovis (biotype)
amiC BQ2027_MB2912C
false
Mycobacterium tuberculosis
428
row_407460
false
null
6,612
O53168
MRRNRRGSPARPAARFVRPAIPSALSVALLVCTPGLATADPQTDTIAALIADVAKANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAEDDLEVSQRAVKDANAAIAAAQHRFDTFAAATYMNGPSVSYLSASSPDEIIATVTAAKTLSASSQAVMANLQRARTERVNTESAARLAKQKADKAAADAKASQDAAVAALTETRRKFDEQREEVQRLAAERDAAQARLQAARLVAWSSEGGQGAPPFRMWDPGSGPAGGRAWDGLWDPTLPMIPSANIPGDPIAVVNQVLGISATSAQVTANMGRKFLEQLGILQPTDTGITNAPAGSAQGRIPRVYGRQASEYVIRRGMSQIGVPYSWGGGNAAGPSKGIDSGAGTVGFDCSGLVLYSFAGVGIKLPHYSGSQYNLGRKIPSSQMRRGDVIFYGPNGSQHVTIYLGNGQMLEAPDVGLKVRVAPVRTAGMTPYVVRYIEY
Peptidoglycan endopeptidase RipA (EC 3.4.-.-) (Macrophage invasion and intracellular persistence protein A) (Resuscitation-promoting factor interaction partner A) (Rpf-interacting protein A)
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
83,332
472
49,808
3D-structure;Cell wall biogenesis/degradation;Hydrolase;Protease;Reference proteome;Secreted;Signal;Thiol protease
GO:0005576; GO:0006508; GO:0008234; GO:0008745; GO:0009274; GO:0071554; GO:0071555
Evidence at protein level
5
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17919286, ECO:0000269|PubMed:26933057}. Note=Secreted by the TAT secretion pathway (PubMed:26933057). Localizes to the septa upon expression in M.bovis or M.smegmatis. Remains associated with the cell. {ECO:0000269|PubMed:26933057}.
SIGNAL 1..39; /note="Tat-type signal"; /evidence="ECO:0000305|PubMed:26933057"
null
PF00877;
IPR000064;IPR038765;IPR051794;IPR049836;
2XIV;3NE0;3PBC;3S0Q;4Q4G;4Q4N;4Q4T;6EWY;
cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Mycobacteriaceae (family), Mycobacterium (genus), Mycobacterium tuberculosis complex (no rank), Mycobacterium tuberculosis (species)
ripA Rv1477
false
Mycobacterium tuberculosis
429
row_5446
false
null