Datasets:
pavanmantha
/
pubmedqa-dataset

Dataset card Data Studio Files
xet
Community
2
question
stringlengths
17
395
long_answer
stringlengths
1
3.34k
Does tNFα cause thrombin-dependent vagal neuron apoptosis in inflammatory bowel disease?
IBD is associated with DMV exposure to TNFα, causing excess DMV prothrombin and vagal apoptosis.
Is a promoter polymorphism of the CYP27B1 gene associated with Addison 's disease , Hashimoto 's thyroiditis , Graves ' disease and type 1 diabetes mellitus in Germans?
The CYP27B1 promoter (-1260) C/A polymorphism appears to be associated with endocrine autoimmune diseases but the CYP27B1 intron 6 (+2838) C/T polymorphism appears to be associated only with Hashimoto's thyroiditis. These results imply a regulatory difference of the CYP27B1 hydroxylase to predispose to endocrine autoimmunity.
Are ganglioside GM3 levels altered in a mouse model of HIBM : GM3 as a cellular marker of the disease?
The M712T mutation of GNE hampers the muscle ability to synthesize normal levels of GM3. This is the first time that a mutation of GNE can be related to the molecular pathological mechanism of HIBM.
Does chronic alcohol ingestion increase mortality and organ injury in a murine model of septic peritonitis?
When subjected to the same septic insult, mice with chronic alcohol ingestion have increased mortality. Alterations in intestinal integrity, the host immune response, and pancreatic metabolomics may help explain this differential response.
Is involvement of mesosalpinx in endometrioma a possible risk factor for decrease of ovarian reserve after cystectomy : a retrospective cohort study?
These results suggest that pre-existing mesosalpinx disturbance, in combination with adhesiolysis, may be involved in the medium- and long-term decrease in ovarian reserve after endometrioma surgery. A disturbance in ovarian blood supply via the mesosalpinx may underlie this.
Does caffeine ingestion improve power output decrement during 3-min all-out exercise?
Caffeine ingestion did not change EP but improved WEP and the rate of decline in power output during short-term, severe exercise.
Do evaluation of a sphere-templated polymeric scaffold as a subcutaneous implant?
Sphere-templated poly(HEMA) implanted as a subcutaneous tissue scaffold stimulates a minimal inflammatory response and supports cellular infiltration, collagen formation, and neovascularization. Because of its tightly controlled porous structure, poly-(HEMA) appears to induce less scar-type ingrowth compared with HDPPE.
Does nano-cerium-element-doped titanium dioxide induce apoptosis of Bel 7402 human hepatoma cells in the presence of visible light?
Ce (IV) doped TiO(2) nanoparticles can induce apoptosis of Bel 7402 human hepatoma cells in the presence of visible light.
Does alendronate decrease orthotopic PC-3 prostate tumor growth and metastasis to prostate-draining lymph nodes in nude mice?
Our results demonstrate that alendronate treatment opposes growth of orthotopic PC-3 tumors and decreases tumor metastasis to prostate-draining lymph nodes. This effect could be at least partly explained by decreased angiogenesis and increased apoptosis. The results suggest that bisphosphonates have anti-tumoral and anti-invasive effects on primary prostate cancer.
Does sudden withdrawal of carbamazepine increase cardiac sympathetic activity in sleep?
Abrupt withdrawal of CBZ leads to enhanced sympathetic activity in sleep as evidenced by increased LF/HF ratios. Increased sympathetic activity in the setting of seizure-induced hypoxia could predispose to SUDEP.
Are multiple prior concussions associated with symptoms in high school athletes?
In this large-scale, retrospective survey study, history of multiple prior concussions was associated with higher symptom burden but not baseline computerized neurocognitive testing. The association between baseline symptom reporting and clinical and demographic factors was greater than the association with a history of multiple concussions.
Does differential-display polymerase chain reaction identify nicotinamide adenine dinucleotide-ubiquinone oxidoreductase as an ischemia/reperfusion-regulated gene in cardiomyocytes?
The NADH:ubiquinone oxidoreductase gene is up-regulated during global cardiac ischemia/reperfusion injury during CPB in canines. To our knowledge, involvement of this gene in global cardiac ischemia/reperfusion injury during CPB has not been described previously. The NADH:ubiquinone oxidoreductase gene may have a role in the regulation of molecular changes during the global cardiac ischemia/reperfusion injury during CPB, such as the up-regulation of Bcl-2, which might block release of cytochrome c from the mitochondria and prevent cardiomyocytic apoptosis.
Does ischemic colitis have a worse prognosis when isolated to the right side of the colon?
A total of 273 cases of biopsy-proven ischemic colitis were identified of which 71 (26.0%) involved only the right side. Patients with IRCI had a worse outcome than those with colon ischemia involving other colon regions, including a fivefold need for surgery and a twofold mortality.
Is anti-TNF-alpha loss of response associated with a decreased percentage of FoxP3+ T cells and a variant NOD2 genotype in patients with Crohn 's disease?
Anti-TNF-α loss of response is associated with a decreased percentage of FoxP3+ T cells and a variant NOD2 genotype in patients with CD.
Does periadventitial adipose tissue play a critical role in vascular remodeling?
Our findings suggest that periadventitial fat may protect against neointimal formation after angioplasty under physiological conditions and that inflammatory changes in the periadventitial fat may have a direct role in the pathogenesis of vascular disease accelerated by obesity.
Is thimerosal-containing Hepatitis B Vaccine Exposure Highly Associated with Childhood Obesity : A Case-control Study Using the Vaccine Safety Datalink?
In a dose-response manner, the present study associates an increased organic mercury exposure from Thimerosal-containing hepatitis B vaccines with an increased risk of obesity diagnosis, and suggests that Thimerosal is an obesogen. The results are biologically plausible and future studies are needed to examine this phenomenon.
Do attachment style and oxytocin receptor gene variation interact in influencing social anxiety?
The present pilot data point to a strong association of less secure attachment and social anxiety as well as to a gene-environment interaction effect of OXTR rs53576 genotype and attachment style on social anxiety possibly constituting a targetable combined risk marker of social anxiety disorder.
Is nonstructural protein Pns4 of rice dwarf virus essential for viral infection in its insect vector?
Pns4 of RDV is essential for viral infection and replication in insect vector. It may directly participate in the functional role of viroplasm for viral replication and assembly of progeny virions during viral infection in leafhopper vector.
Is serum extracellular vesicular miR-21-5p a predictor of the prognosis in idiopathic pulmonary fibrosis?
Our results suggest that serum EV miR-21-5p has potential as a prognostic biomarker for IPF.
Are comorbid behavioural problems in Tourette 's syndrome positively correlated with the severity of tic symptoms?
The findings indicated that children with TS-only also had a broad range of behavioural problems, and some of these were related to the severity of tic symptoms.
Is persistence of Neisseria gonorrhoeae DNA following treatment for pharyngeal and rectal gonorrhea influenced by antibiotic susceptibility and reinfection?
Pharyngeal and rectal gonorrhea DNA persisted in 8% of men 14 days after treatment. Persistence was associated with elevated ceftriaxone and azithromycin MICs. Persistence can also reflect reinfection.
Does curcumin enhance non-opsonic phagocytosis of Plasmodium falciparum through up-regulation of CD36 surface expression on monocytes/macrophages?
CD36 expression and CD36-mediated P. falciparum phagocytosis by curcumin are dependent on ROS production and probably involve the Nrf2 pathway. The dual immunomodulatory and antimalarial mechanisms of curcumin action may mean that curcumin has potential as an adjuvant treatment limiting the risk of recrudescence following standard antimalarial therapy.
Is satisfaction ( sexual , life , relationship , and mental health ) associated directly with penile-vaginal intercourse , but inversely with other sexual behavior frequencies?
The results are consistent with evidence that specifically PVI frequency, rather than other sexual activities, is associated with sexual satisfaction, health, and well-being. Inverse associations between satisfaction and masturbation are not due simply to insufficient PVI.
Does pitavastatin decrease the expression of endothelial lipase both in vitro and in vivo?
These findings suggest that statins can reduce EL expression in vitro and in vivo via inhibition of RhoA activity. The inhibition of EL expression in the vessel wall may contribute to the anti-atherogenic effects of statins.
Does total disc arthroplasty affect the incidence of adjacent segment degeneration in cervical spine : results of 93 patients in three prospective randomized clinical trials?
Total disc arthroplasty is equivalent to ACDF for providing relief from symptoms in the treatment of one- and two-level DDD of cervical spine. The risk of developing adjacent segment degeneration is equivalent after both procedures but is significantly higher in patients with concurrent DDD in lumbar spine.
Do maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy?
Pyelonephritis in pregnant women is associated with an increased maternal serum concentration of the chemokine CXCL10/IP-10.
Does transesophageal atrial pacing reduce phenylephrine needed for blood pressure support during carotid endarterectomy?
Under controlled conditions of general anesthesia for carotid endarterectomy, transesophageal atrial pacing reduced by 40% the amount of phenylephrine needed for blood pressure support and helped in the treatment of disadvantageous sinus bradycardia.
Does interleukin-1 receptor-associated kinase-M in gingival epithelial cells attenuate the inflammatory response elicited by Porphyromonas gingivalis?
Interleukin-1 receptor-associated kinase-M appeared to have distinct regulatory roles on the interleukin-8 and MCP-1 produced by HGECs, further suggesting an important role for interleukin-8 in the immune response to periodontopathic bacteria.
Are patients with non-ST-elevation myocardial infarction and without chest pain treated less aggressively and experience higher in-hospital mortality?
There is a significant group of ACS patients without chest pain on admission who are usually women with less severe past medical history. This subset of patients is treated less aggressively in terms of antiplatelet therapy and invasive approach. It is patients with diagnosis of NSTEMI who due to being misdiagnosed due to their atypical chest pain have poorer outcome.
Do antimicrobials increase travelers ' risk of colonization by extended-spectrum betalactamase-producing Enterobacteriaceae?
TD and antimicrobials for TD proved to be independent risk factors, with up to 80% of TD+AB+ travelers contracting ESBL-PE. In modern pre-travel counseling for those visiting high-risk regions, travelers should be advised against taking antibiotics for mild or moderate TD.
Does alemtuzumab preconditioning allow steroid-calcineurin inhibitor-free regimen in live-donor kidney transplant?
This clinical trial provides a good insight into a potentially effective steroid and calcineurin inhibitor-free protocol with the use of alemtuzumab induction in combination with sirolimus.
Does compression therapy in mixed ulcers increase venous output and arterial perfusion?
In patients with mixed ulceration, an ankle-brachial pressure index >0.5 and an absolute ankle pressure of >60 mm Hg, inelastic compression of up to 40 mm Hg does not impede arterial perfusion but may lead to a normalization of the highly reduced venous pumping function. Such bandages are therefore recommended in combination with walking exercises as the basic conservative management for patients with mixed leg ulcers.
Does mVA-MUC1-IL2 vaccine immunotherapy ( TG4010 ) improve PSA doubling time in patients with prostate cancer with biochemical failure?
Although the primary endpoint was not achieved, there is evidence of biologic activity of TG4010 in patients with PSA progression, further investigation in prostate cancer is warranted.
Does the prognostic nutritional index predict long-term outcomes of gastric cancer patients independent of tumor stage?
The PNI is a simple and useful marker for predicting the long-term outcomes of gastric cancer patients independent of the tumor stage. Based on our results, we suggest that the PNI should be included in the routine assessment of gastric cancer patients.
Does exercise-based cardiac rehabilitation improve hemodynamic responses after coronary artery bypass graft surgery?
Cardiac rehabilitation significantly improves functional capacity and some hemodynamic responses post coronary artery bypass grafting. Therefore, patients need to be referred to rehabilitation units.
Does mast cell-dependent tumor necrosis factor alpha production participate in allergic gastric inflammation in mice?
These findings show that mast cell-derived TNF-alpha is at least one of the mediators involved in the recruitment of neutrophils during immunoglobulin E-dependent gastric inflammation in the mouse.
Is peculiar glucagon processing in the intestine the genesis of the paradoxical rise of serum pancreatic glucagon in patients after total pancreatectomy?
The paradoxical rise in IRGs based on the findings of gel filtration chromatography in group PX were possibly due to the generated peculiar glicentin-like peptide from the glucagon precursor, preproglucagon, after total pancreatectomy, which might be processed in intestines in association with the insulin deficiencies.
Does pulsed magnetic therapy increase osteogenic differentiation of mesenchymal stem cells only if they are pre-committed?
We concluded that PEMFs affect the osteogenic differentiation of ADSCs only if they are pre-commitment and that this therapy can be an appropriate candidate for treatment of conditions requiring an acceleration of repairing process.
Do comparison of the efficacy of single volar subcutaneous digital block and the dorsal two injections block?
Single injection volar subcutaneous digital block provides faster onset of anaesthesia, produces predictable, consistent dense anaesthesia of all of the fingers with the help of single injection prick.
Does early stage of left atrium remodelling predict better outcome in long-term follow-up of atrial fibrillation ablation?
AF ablation should be performed in the early stage of AF, before structural remodelling development.
Do rheumatoid arthritis synovial fluid fibroblasts express TRAIL-R2 ( DR5 ) that is functionally active?
Fibroblasts grown from the synovial fluid and synovial membrane of RA patients express TRAIL-R2 that is functionally active. An agonistic anti-TRAIL-R2 antibody that does not induce hepatocyte toxicity may be an alternative strategy for treatment of RA.
Is directed neutrophil migration to IL-8 increased in cystic fibrosis : a study of the effect of erythromycin?
CF derived PMNs show higher migratory responsiveness to IL-8 but not to fMLP, suggesting that CF PMNs may be "primed" to IL-8 which is significantly increased in CF serum compared with non-CF serum. Treatment with erythromycin had no significant effect on PMN migration in vitro.
Does recombinant human activated protein C reset thrombin generation in patients with severe sepsis - a case control study?
Sepsis-induced thrombin generation in severely septic patients is reset by rhAPC within the first 8 h of infusion without influencing parameters of fibrinolysis and inflammation.
Is b-type natriuretic peptide a strong independent predictor of long-term outcome after transcatheter aortic valve implantation?
In patients undergoing TAVI, plasma BNP is the strongest independent predictor of all-cause mortality and cardiovascular mortality. Plasma BNP levels at 30 days after TAVI may provide prognostic information that should, potentially, lead to a more intensive therapy of these patients.
Is phosphorylation of the Twist1-family basic helix-loop-helix transcription factors involved in pathological cardiac remodeling?
This study provides novel insights into the regulation of Twist1 family in cardiac remodeling and suggests that the Twist1 family can be regulated by Akt signaling.
Does delta-4 Notch ligand promote erythroid differentiation of human umbilical cord blood CD34+ cells?
By modifying Delta-4 expression of the stromal cells and using the recombinant protein, we demonstrated that Delta-4 had a differentiation promoting activity for human primitive hematopoietic cells into erythroid lineage.
Do autoreactive T cells induce in vitro BM mesenchymal stem cell transdifferentiation to neural stem cells?
We observed that autoreactive cells may induce the transdifferentiation of MSC to neural stem cells. This T-cell-MSC interaction may be a common phenomenon during physiologic nerve tissue repair.
Is primary biliary cirrhosis associated with specific changes in liver IgG-bearing cell subpopulations?
These data suggest a pathogenetic role of local IgG3-bearing cells in primary biliary cirrhosis.
Does links between core promoter and basic gene feature influence gene expression?
Our results suggest that interplay between core promoter type and gene size can generate significant diversity in gene expression.
Do heparin and protamine titration improve haemostasis in cardiac surgical patients?
In cardiac surgical patients, heparin and protamine titration did predict a lower protamine dose but did not result in a measurable improvement in haemostasis during the perioperative period.
Do natriuretic peptides modify Pseudomonas fluorescens cytotoxicity by regulating cyclic nucleotides and modifying LPS structure?
These observations support the hypothesis that P. fluorescens responds to natriuretic peptides through a putative sensor system coupled to a cyclase that could interfere with LPS synthesis and thereby modify the overall virulence of the micro-organism.
Does vSL # 3 Probiotic stimulate T-cell Protein Tyrosine Phosphatase-mediated Recovery of IFN-γ-induced Intestinal Epithelial Barrier Defects?
VSL#3 reduces IFN-γ signaling and IFN-γ-induced epithelial barrier defects in a TCPTP-dependent manner. These data point to a key role for TCPTP as a therapeutic target for restoration of barrier function using probiotics.
Does mHC mismatch inhibit neurogenesis and neuron maturation in stem cell allografts?
These results suggest an important but unsuspected role for innate, rather than adaptive, immunity in the survival and function of MHC-mismatched cellular grafts in the CNS.
Does patients with recurrent fall attending Accident & Emergency benefit from multifactorial intervention -- a randomised controlled trial?
Multifactorial intervention is effective at reducing the fall burden in cognitively intact older persons with recurrent falls attending Accident & Emergency, but does not reduce the proportion of subjects still falling.
Does online training improve paramedics ' knowledge of autonomic dysreflexia management guidelines?
'ABCs of AD' has immediate and sustained effects on paramedics' knowledge of attitudes toward and perceived pressure from patients to use the AD-CPGs. Updates to paramedic patient care guidelines and standards are needed to increase paramedics' perceived control and self-efficacy to implement the guidelines, and their intentions to use the AD-CPGs.
Does enteric-coated mycophenolate sodium containing GvHD prophylaxis reduce GvHD rate after allogeneic HSCT?
This data support the hypothesis that replacement of MMF or MTX by EC-MPS reduces GvHD rates after HSCT. This appears not to be due to a reduced GI-toxicity of EC-MPS.
Do high-oxygen and high-carbon dioxide containing atmospheres inhibit growth of food associated moulds?
This study demonstrates the potential use of elevated oxygen levels in a modified atmosphere to inhibit food-associated mould growth.
Are mild elevations of urine albumin excretion associated with atherogenic lipoprotein abnormalities in the Multi-Ethnic Study of Atherosclerosis ( MESA )?
Mild elevations of urine ACR are associated with atherogenic lipoprotein abnormalities that are not directly observed with a standard lipid panel.
Does invasive Assessment of Coronary Physiology predict Late Mortality After Heart Transplantation?
Invasive measures of coronary physiology (fractional flow reserve and IMR) determined early after heart transplantation are significant predictors of late death or retransplantation.
Does postoperative opioid administration inhibit bone healing in an animal model?
Morphine administration inhibited callus strength in this animal model. This finding is likely consistent with the observation that the callus and healing bone appear to have a decreased rate of maturation and remodeling seen at 8 weeks.
Do alarmins from corneal epithelial cells upregulate CCL11 and VCAM-1 in corneal fibroblasts?
Alarmins including IL-1 released from necrotic corneal epithelial cells cooperate with Th2 cytokines to induce CCL11 production and VCAM-1 expression in corneal fibroblasts, and may thereby play an important role in tissue eosinophilia associated with ocular allergic diseases.
Is the elevation in circulating anti-angiogenic factors independent of markers of neutrophil activation in preeclampsia?
Increased systemic inflammation in sPE and SIR does not correlate with increased anti-angiogenic factors, which were specifically elevated in sPE indicating that excessive systemic inflammation is unlikely to be the main contributor to severe preeclampsia.
Do the overlap of interstitial cystitis/painful bladder syndrome and overactive bladder?
Many patients with symptoms of overactive bladder with little or no pain have cystoscopic evidence of interstitial cystitis and a positive Potassium Sensitivity Test. Therapies directed toward the uroepithelial dysfunction and neural upregulation associated with interstitial cystitis/painful bladder syndrome may be an important adjunct for patients who have failed or have had a partial response to anticholinergic therapy and behavior modification.
Is myopia in young adults inversely related to an objective marker of ocular sun exposure : the Western Australian Raine cohort study?
In this young adult population, myopic refractive error was inversely associated with objectively measured ocular sun exposure, even after adjustment for potential confounders. This further supports the inverse association between outdoor activity and myopia.
Does occurrence of pigment precipitate after small incision cataract surgery?
The development of pigment precipitates after foldable IOL implantation did not appear to be affected by the presence of glaucoma or diabetes. Newer, slimmer IOL styles and refined insertion techniques were associated with a lower occurrence of precipitates.
Does intrabone marrow injection enhance placental mesenchymal stem cellmediated support of hematopoiesis in mice?
Our results not only elucidated the role of PMSCs in promoting hematopoiesis, but also revealed the therapeutic potential of the combination of PMSCs and IBMI in transplantation.
Does c-kit expression in adenoid cystic carcinoma have an impact on local or distant tumor recurrence?
Our results suggest that expression of c-kit may not serve as a useful marker for predicting outcome in ACC, although they need to be confirmed in a larger patient population with longer clinical follow-up.
Does intravenous pretreatment with emulsified isoflurane preconditioning protect kidneys against ischemia/reperfusion injury in rats?
Intravenous EIso produces preconditioning against renal I/R injury in rats, which might be mediated by attenuating inflammation and increasing antioxidation ability.
Does cardiogenic Shock predict Long-term Mortality in Hospital Survivors of STEMI Treated With Primary Percutaneous Coronary Intervention?
Cardiogenic shock remains a strong predictor of long-term mortality in hospital survivors of STEMI treated by primary percutaneous coronary intervention.
Does functional fitness gain vary in older adults depending on exercise mode?
Results suggest that a single mode with crossover effects could address multiple components of fitness. Therefore, a well-rounded exercise program may only need to consist of two types of exercise to improve the components of functional fitness. One type should be aerobic exercise, and the second type could be chosen from RES, BAL, and T-CHI.
Does never-frozen liquid plasma block endothelial permeability as effectively as thawed fresh frozen plasma?
LQP corrected TNF-α-induced EC permeability and preserved hemostatic potential after 28 days of storage, similar to TP stored for 5 days. The significant logistical benefit (fivefold) of prolonged LQP storage improves the immediate availability of plasma as a primary resuscitative fluid for bleeding patients.
Does rod-Cone Dystrophy with Initially Preserved Visual Acuity Despite Early Macular Involvement suggest Recessive CERKL Mutations?
The initial presenting features of CERKL-related retinopathy are distinct and unusual. Recognition of this initial presenting phenotype can facilitate earlier molecular diagnosis and genetic counseling.
Does the phenotype of polycystic ovary syndrome ameliorate with aging?
The PCOS phenotype changed with aging, suggesting an amelioration of the phenotype and ovarian dysfunction as indicated by the increase in number of regular menstrual cycles, decrease in serum androgen levels, and decrease in insulin resistance.
Is mx2 expression associated with reduced susceptibility to HIV infection in highly exposed HIV seronegative Kenyan sex workers?
This is the first epidemiological report of Mx2 and its association with altered susceptibility to HIV infection in HESN women. Additionally, we show that HESN women who use Depo-Provera have the highest levels of Mx2 expression, highlighting a possible mechanism for hormonal modulation of HIV susceptibility.
Is low-density lipoprotein receptor-related protein-5 C/T polymorphism in exon 18 associated with C peptide and proinsulin levels in control women and patients with polycystic ovary syndrome?
Polymorphism of C/T in the low-density lipoprotein receptor-related protein-5 gene is associated with C-peptide and proinsulin secretion but does not influence insulin sensitivity in either healthy women or women with polycystic ovary syndrome.
Does interleukin-2 receptor antibody reduce rejection risk in low immunological risk or tacrolimus-treated intermediate immunological risk renal transplant recipients?
This registry analysis suggests that IL-2Ra induction may be associated with a reduction in rejection risk in cyclosporine-treated intermediate immunological risk recipients, but not in low-risk renal transplant recipients.
Does ischemia induce different levels of hypoxia inducible factor-1α protein expression in interneurons and pyramidal neurons?
These results suggest that HIF-1α protein expression induced by ischemia is neuron-type specific and that this specificity may be related to the intracellular level of glutathione (GSH).
Do hepatitis B virus core protein variations differ in tumor and adjacent nontumor tissues from patients with hepatocellular carcinoma?
Accumulation of naturally occurring mutations in certain restricted segments of HBcAg may be related to the development of HCC.
Do benzodiazepine site agonists differentially alter acetylcholine release in rat amygdala?
ACh release in the amygdala was decreased by IV delivery of midazolam and eszopiclone. Dialysis delivery directly into the amygdala caused either increased (eszopiclone and diazepam) or likely no significant change (midazolam and zolpidem) in ACh release. These contrasting effects of delivery route on ACh release support the interpretation that systemically administered midazolam and eszopiclone decrease ACh release in the amygdala by acting on neuronal systems outside the amygdala.
Does the Met allele of the BDNF Val66Met polymorphism predict poor outcome among survivors of aneurysmal subarachnoid hemorrhage?
Genetically influenced variation in BDNF function plays a role in recovery from subarachnoid hemorrhage. These data indicate that augmentation of BDNF signaling may be beneficial to recovery from brain injury.
Do insurance status and race affect treatment and outcome of traumatic brain injury?
Race/ethnicity and insurance status significantly affect TBI patient outcomes, even after controlling for demographic and injury characteristics.
Does sleep enhance learning of a functional motor task in young adults?
Time-of-day effect and inability to ensure a certain amount of sleep quantity and quality of participants were limitations of the study.
Does albumin-bound nanoparticle ( nab ) paclitaxel exhibit enhanced paclitaxel tissue distribution and tumor penetration?
Compared with CrEL-paclitaxel, nab-paclitaxel demonstrated more efficient transport across endothelial cells, greater penetration and cytotoxic induction in xenograft tumors, and enhanced extravascular distribution in patients that are attributed to carrier-mediated transport. These observations are consistent with the distinct clinical efficacy and toxicity profile of nab-paclitaxel.
Does long-term endothelin receptor antagonism attenuate coronary plaque progression in patients with early atherosclerosis?
This study demonstrates that 6-month treatment with Atrasentan attenuates progression of coronary plaque in segments with endothelial dysfunction.
Does haploinsufficiency of target of rapamycin attenuate cardiomyopathies in adult zebrafish?
Our results prove adult zebrafish as a conserved novel vertebrate model for human cardiomyopathies. Moreover, we provide the first genetic evidence to demonstrate a long-term cardioprotective effect of TOR signaling inhibition on at least 2 cardiomyopathies of distinct etiology, despite dynamic TOR activities during their pathogenesis.
Do elevations of serum CA-125 predict severity of acute appendicitis in males?
CA-125 levels correlate with the severity of appendicitis in males and may serve as a surrogate marker for the severity of other intra-abdominal surgical diseases.
Does epithelial MMP-2 expression correlate with worse prognosis in pancreatic cancer?
Epithelial MMP-2 correlates with advanced tumor stage and grade, but is not an independent predictor of survival.
Does glutamine depletion induce murine neonatal melena with increased apoptosis of the intestinal epithelium?
Glutamine is an important alimentary component for the maintenance of intestinal mucosa. Glutamine deprivation can cause instability of the intestinal epithelial alignment by increased apoptosis.
Does g-CSF improve systolic function in a rat model of acute myocardial infarction?
These data clearly shows that G-CSF treatment was unable to prevent cardiac remodeling or to improve cardiovascular function in a rat model of acute myocardial infarction, by permanent LAD ligation, despite bone marrow stem cell mobilization.
Is antral follicle count increased in obese women placed on oral contraceptive pills?
Use of suppressive medications like OCPs in obese women increases AFC during IVF, potentially by AFC cohort synchrony. This observation warrants consideration when using AFC to predict gonadotropin/ART response as well as future prospective research to further elucidate potential etiologies.
Does rTMS modulate reciprocal inhibition in patients with traumatic spinal cord injury?
In a small proof-of-concept study, rTMS strengthened descending projections between the motor cortex and inhibitory spinal interneuronal circuits. This reversed a defect in reciprocal inhibition after SCI, and reduced leg spasticity.
Does [ K83 site affect PICK1 PDZ binding ability ]?
The K83 site in PDZ domain of PICK1 is important for the interaction between PICK1 and GluR2. Altering lysine will probably change the hydrophobic interactions, the hydrogen bonds or the electrostatic interactions formed between PICK1 PDZ domain and GluR2 C terminal; accordingly, that will change the binding capacity between PICK1 and GluR2 in varying degrees.
Does rye bread intake improve oxidation resistance of LDL in healthy humans?
Rye bread intake improved significantly the oxidation resistance of LDL. Further studies are needed to clarify the protective mechanism(s).
Does iron deficiency predict poor maternal thyroid status during pregnancy?
Poor maternal iron status predicts both higher TSH and lower TT4 concentrations during pregnancy in an area of borderline iodine deficiency.
Does [ Maternal iron overload result in liver damage in rat offspring ]?
Iron overload in maternal rats may result in excessive iron deposition and oxidative damage of liver tissue and cell function in maternal rats' offspring.
Is compartmentalization of HIV-1 within the female genital tract due to monotypic and low-diversity variants not distinct viral populations?
In women with chronic HIV-1 infection multiple identical sequences suggest proliferation of HIV-1-infected cells, and low diversity tissue-specific phylogenetic clades are consistent with bursts of viral replication. These monotypic and tissue-specific viruses provide statistical support for compartmentalization of HIV-1 between the female genital tract and blood. However, the intermingling of these clades with clades comprised of both genital and blood sequences and the absence of tissue-specific genetic features suggests compartmentalization between blood and genital tract may be due to viral replication and proliferation of infected cells, and questions whether HIV-1 in the female genital tract is distinct from blood.
Is shear stress downregulation of platelet-derived growth factor receptor-beta and matrix metalloprotease-2 associated with inhibition of smooth muscle cell invasion and migration?
SS inhibits SMC migration and invasion via diminished PDGF-Rbeta expression. This effect of SS is associated with decreased MMP-2 secretion and MT-MMP downregulation.
Are proton pump inhibitors associated with a high rate of serious infections in veterans with decompensated cirrhosis?
Among patients with decompensated cirrhosis, proton pump inhibitors but not H2 receptor antagonists increase the rate of serious infections.
Is non-alcoholic fatty liver disease ( NAFLD ) associated with low level of physical activity : a population-based study?
Data from this study show that non-alcoholic fatty liver disease patients have low level of physical activity and, when they have diabetes mellitus, they perform at the lowest quartile of physical activity and moderate-vigorous physical activity.
Do high CRP values predict poor survival in patients with penile cancer?
A high preoperative serum CRP level was associated with poor survival in patients with penile cancer. If larger patient populations confirm its prognostic value, its routine use could enable better risk stratification and risk-adjusted follow-up of patients with SCC of the penis.