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Is surgeon volume associated with cost and variation in surgical treatment of proximal humeral fractures?
Higher surgeon volume was associated with lower hospital costs for proximal humeral fractures. Therefore, policies on minimum volume requirements by hospitals may result in substantial cost savings. There is provider-based practice variation in the surgical treatment of proximal humeral fractures and evidence-based guidelines in this area are needed.
Does platelet concentrate stored for 5 days in a reduced volume of plasma maintain hemostatic function and viability?
The in vivo viability, recovery, and hemostatic function of platelets collected in polyvinylchloride plastic containers and stored in 30 to 35 mL of plasma for 5 days are maintained as well as those of platelets stored in 50 to 60 mL of plasma.
Does gene expression profiling of porokeratosis demonstrate similarities with psoriasis?
This study supports the hypothesis that PK is a disorder of hyperproliferative keratinocytes exhibiting similarity at the molecular level to psoriasis. Consequently, some therapeutic modalities efficacious for psoriasis may be of benefit in PK.
Does [ Compound Xuanju capsule improve sex hormones and sex organ indexes in castrated male rats ]?
Compound Xuanju Capsule can elevate T and LH levels in the peripheral blood of male SD rats and improve the indexes of their sex organs, which may be an important mechanism behind its effect on ED.
Does effects of TiO2 nano glass ionomer cement against normal and cancer oral cells?
The present study shows acceptable to moderate biocompatibility of GICs impregnated with TiO2 nanoparticles, as well as its pro-inflammatory effects at higher concentrations.
Does audit of resuscitation decisions have little impact on clinical practice?
Clinical audit may lead to short-term improvements in resuscitation decision-making, but this improvement does not appear to be sustained over time. Other measures need to be considered to improve practice in this area.
Does androgen ablation promote neuroendocrine cell differentiation in dog and human prostate?
The dog is a suitable animal model and mimics the human, since androgen ablation favored prostatic NE differentiation in both species. The down-regulation elicited by steroids suggests that the process may be reversible and hormonally-repressed.
Does nanoencapsulation in lipid-core nanocapsules control mometasone furoate skin permeability rate and its penetration to the deeper skin layers?
This formulation is suitable for prolonged treatment of skin disorders which should avoid systemic absorption.
Is transient receptor potential vanilloid type 1 vital for ( - ) -epigallocatechin-3-gallate mediated activation of endothelial nitric oxide synthase?
EGCG may trigger activation of TRPV1-Ca(2+) signaling, which leads to phosphorylation of Akt, AMPK, and CaMKII; eNOS activation; NO production; and, ultimately, angiogenesis in ECs.
Do [ Laparoscopic surgery for inflammatory bowel disease ; an update ]?
Laparoscopic ileocaecal resection is preferable in Crohn's disease, provided that it is performed in a centre with sufficient expertise in laparoscopic surgery. In patients with ulcerative colitis, laparoscopic proctocolectomy with construction of an ileoanal pouch is indicated in young active patients who are concerned for their appearance. Given its complexity, this operation should be performed only in specialist centres.
Does limbic white matter microstructure plasticity reflect recovery from depression?
All patients were medicated, sample size, and lack of control group.
Are two avirulent , lentogenic strains of Newcastle disease virus cytotoxic for some human pancreatic tumor lines in vitro?
On average, 1,555 times more NDV-B1 was needed to kill normal cells than most pancreatic tumor cells and 558 times more NDV-U to kill the two most sensitive pancreatic cancer lines. These innately-targeted lentogenic viruses may have meaningful potential in treating pancreatic cancer.
Does neutralization of interleukin-1beta in the acute phase of myocardial infarction promote the progression of left ventricular remodeling?
Anti-IL-1beta treatment suppressed pro-collagen gene expression and delayed wound healing mechanisms-properties that are likely to lead to progression of LV remodeling. In the acute phase of MI, IL-1beta appears to play a protective role.
Are mHC-IIB filament assembly and cellular localization governed by the rod net charge?
A correct distribution of positive and negative charges along myosin II rod is a necessary component in proper filament assembly and intracellular localization of MHC-IIB.
Does acute tryptophan depletion alter gastrointestinal and anxiety symptoms in irritable bowel syndrome?
IBS patients' GI and anxiety responses to changes in tryptophan load differ from controls. This suggests a difference in serotonergic functioning between these two groups and provides evidence to support the hypothesis that 5-HT dysfunction is involved in IBS.
Is tumor angiogenesis associated with progression after radical prostatectomy in pT2/pT3 prostate cancer?
In this study, tumor angiogenesis measured by MVD was associated with a dismal pathologic appearance and a negative clinical prognosis in PC after radical prostatectomy.
Is dog walking associated with more outdoor play and independent mobility for children?
Dog-facilitated play and physical activity can be an effective strategy for increasing children's physical activity. Dog walking may provide a readily accessible and safe option for improving levels of independent mobility.
Is higher insulin sensitivity in vegans associated with higher mitochondrial density?
Vegans have a higher IS, but comparable mitochondrial density and IMCL content with omnivores. This suggests that a decrease in whole-body glucose disposal may precede muscle lipid accumulation and mitochondrial dysfunction in IR development.
Does metformin alter the risk of lung cancer : a case-control analysis?
Metformin did not decrease the risk of lung cancer.
Does water bath hyperthermia reduce stemness of colon cancer cells?
All the findings indicate that hyperthermia has an important effect on the stemness of colon cancer cells.
Does igG1 subclass dominate autoimmune response to tyrosine phosphatase-like molecule IA-2 in Chinese type 1 diabetes patients?
Isotype responses to IA-2 had a strong IgG1 presence, similar to ICAs and GADab. With IgG3 subclass representation, a predominant Th1 milieu in the systemic environment is likely. There is no suggestion of differences in immune response to IA-2 between adults and children with type 1 diabetes.
Is desmoid tumor-associated pain dependent on mast cell expression of cyclooxygenase-2?
Our results indicated that COX-2 secretion from mast cells modulates desmoid tumor-associated pain. In addition, mast cells may at least in part contribute to the pathogenesis of desmoid tumors.
Are within-pair differences of DNA methylation levels between monozygotic twins different between male and female pairs?
Sex-related differences were present in the WPDMs of CpG islands in individuals with the same genetic background. These differences may be associated with the sexual influences in susceptibility of some diseases.
Is adipose tissue CIDEA associated , independently of weight variation , to change in insulin resistance during a longitudinal weight control dietary program in obese individuals?
The concomitant change in adipose tissue CIDEA mRNA levels and insulin sensitivity suggests a beneficial role of adipose tissue CIDEA in long term glucose homeostasis, independently of weight variation.
Is the chemokine receptor CXCR4 expressed in pancreatic intraepithelial neoplasia?
Together these results demonstrate that CXCL12/CXCR4 expression begins in the pre-invasive stages of pancreatic neoplasia, and suggest that the presence of an autocrine loop that is at least partially regulated by MAPK signalling. Further studies that define the role of CXCR4 signalling in PanIN progression will determine if CXCR4 could serve as a novel target for chemoprevention and early stage therapy in pancreatic cancer.
Does hPV prophylactic vaccination in males improve the clearance of semen infection?
Humoral immunity has a major role in healing from HPV infection. Elder ART patients with HPV semen infection may benefit by the union of both specific counselling and available prophylactic vaccination.
Are elastin-derived peptides new regulators of thrombosis?
These results highlight the complex nature of the mechanisms governing thrombus formation and reveal an unsuspected regulatory role for circulating EDP in thrombosis.
Does eEG coherence reflect regional corpus callosum area in Alzheimer 's disease?
Region specific correlations between corpus callosum size and EEG coherence suggest that the decline in interhemispheric connectivity in Alzheimer's disease results from a specific loss of cortical association neurones projecting through the corpus callosum.
Is a newly created splice donor site in exon 25 of the MyBP-C gene responsible for inherited hypertrophic cardiomyopathy with incomplete disease penetrance?
Penetrance of this mutation was incomplete and age-dependent. The large number of asymptomatic carriers and the good prognosis support the interpretation of benign disease.
Is pseudomonas aeruginosa in patients without cystic fibrosis strongly associated with chronic obstructive lung disease?
P. aeruginosa is an opportunistic bacterium infecting primarily patients with severe lung disease. Our data show a significant reduction in lung function among P. aeruginosa-positive non-CF patients over a three-year period of time. The reduction, however, is not different than otherwise reported in COPD patients in general leading to no conclusion as to whether this pathogen is a marker of disease progression or the cause for progression itself.
Does aberrant DNA methylation silence the novel heat shock protein H11 in melanoma but not benign melanocytic lesions?
The heat shock protein H11 is silenced by aberrant DNA methylation in melanoma, but not benign melanocytic lesions or normal skin melanocytes. The data suggest that H11 is a promising target for the molecular therapy of melanoma.
Is ethyl nitrite produced in the human stomach from dietary nitrate and ethanol , releasing nitric oxide at physiological pH : potential impact on gastric motility?
These data pinpoint posttranslational modifications as an underappreciated mechanism for the production of novel molecules with physiological impact locally in the gut and highlight the notion that diet may fuel compounds with the potential to modulate gastrointestinal welfare.
Is the genomic expression test EndoPredict a prognostic tool for identifying risk of local recurrence in postmenopausal endocrine receptor-positive , her2neu-negative breast cancer patients randomised within the prospective ABCSG 8 trial?
EndoPredict is an effective prognostic tool for predicting LRFS. Among postmenopausal, low-risk patients, EP does not appear to be useful for tailoring local therapy.
Does deep sequencing of small RNA facilitate tissue and sex associated microRNA discovery in zebrafish?
This study comprehensively identifies tissue and sex associated miRNAs in zebrafish. Further, we have discovered 459 novel pre-miRNAs (~30 % seed homology to human miRNA) as a genomic resource which can facilitate further investigations to understand miRNA-mRNA gene regulatory networks in zebrafish which will have implications in understanding the function of human homologs.
Are maternal serum but not breast milk IL-5 , IL-6 , and IL-13 immune markers associated with scratching among infants?
Scratching but not doctors diagnosed eczema was associated with higher levels of maternal IL-5, IL-6, and IL-13 during pregnancy. Further investigations are necessary to determine how maternal serum IMs influence infants scratching.
Does insertion/deletion polymorphism of the angiotensin-converting enzyme considerably change postoperative outcome?
ACE ID polymorphism is associated with a higher incidence of postoperative complications, including postoperative infections, in patients undergoing cardiac valve surgery.
Do oNF trainee awards contribute to capacity building in neurotrauma?
A high proportion of past award recipients remain involved in neurotrauma activities, especially in research. These results may lead to a cautious conclusion of the positive impact of the ONF studentships and fellowships on neurotrauma capacity building. These results should be considered in strategic planning of funding agencies similar to ONF.
Is aortic arch calcification detectable on chest X-ray a strong independent predictor of cardiovascular events beyond traditional risk factors?
AAC detectable on chest X-ray is a strong independent predictor of CV events beyond traditional risk factors including endothelial dysfunction. Risk stratification by assessment of AAC may provide important information for management of atherosclerotic disease.
Does oligonol promote anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway?
These data demonstrated that oligonol may act as an anti-aging molecule by modulating SIRT1/autophagy/AMPK pathways.
Do authors ' self-declared financial conflicts of interest impact the results of major cardiovascular trials?
Authors' self-declared FCOI and source of funding do not seem to impact outcomes in major cardiovascular clinical trials.
Does the conformational flexibility of the C-terminus of histone H4 promote histone octamer and nucleosome stability and yeast viability?
The functional consequences of altering the conformational flexibility in the C-terminal tail of H4 are severe. Interestingly, despite the detrimental effects of the histone H4 G94P mutant on viability, nucleosome formation was not markedly affected in vivo. However, histone octamer stability and nucleosome stability as well as nucleosome sliding ability were altered in vitro. These studies highlight an important role for correct interactions of the histone H4 C-terminal tail within the histone octamer and suggest that maintenance of a stable histone octamer in vivo is an essential feature of chromatin dynamics.
Are rAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 new prognostic biomarkers in serous epithelial ovarian cancer?
In this systematic study, we show that RAN and two protein partners involved in its nucleo-cytoplasmic and mitotic functions (XPO7 and TPX2, respectively) can be used as biomarkers to stratify patients based on prognosis. In particular, we reported for the first time the clinical relevance of the exportin XPO7 and showed that TPX2 expression had the strongest prognostic value. These findings suggest that protein partners in each of RAN's functions can discriminate between different outcomes in high-grade serous epithelial ovarian cancer patients. Furthermore, these proteins point to cellular processes that may ultimately be targeted to improve the survival in serous epithelial ovarian cancer.
Is chronic thromboembolic pulmonary hypertension associated with iron overload?
CTEPH has no association with iron overload. The iron status evaluated by sTfR and ferritin is within the normal limits in this CTEPH population.
Is elevation in D-dimer concentrations positively correlated with gestation in normal uncomplicated pregnancy?
10% of the pregnant women in this population had elevated D-dimer levels over 500 ng/mL, and through comparison with what has been reported in the literature, there is the possibility that this group may be at risk of thrombosis. Further studies, incorporating other diagnostic parameters, may be needed before a more logical conclusion can be drawn, since the D-dimer is not a specific test.
Is visceral fat associated with lower brain volume in healthy middle-aged adults?
In middle-aged community participants, we observed a significant inverse association of anthropometric and CT-based measurements of abdominal, especially visceral, fat with total brain volume.
Is the risk of coronary artery disease in population of Taiwan associated with Cys-Ser 311 polymorphism of human paraoxonase ( PON ) -2 gene?
Our data implicate that the genotypic variation at codon 311 of PON2 contributes to the susceptibility of CAD in the population of Taiwan.
Do vascular occlusion sites determine differences in lesion growth from early apparent diffusion coefficient lesion to final infarct?
Initial ADC lesions can be small, even in patients with proximal vascular occlusions. These patients develop considerably large infarctions, suggesting a high potential for infarct growth. This growth might be averted with improved early recanalization of proximal vascular occlusions.
Does human papillomavirus predict outcome in oropharyngeal cancer in patients treated primarily with surgery or radiation therapy?
HPV status predicts better outcome in oropharyngeal cancer treated with surgery plus adjuvant radiotherapy as well as with definitive radiation therapy±chemotherapy.
Does orthostatic hypotension increase cardiovascular risk in the elderly at a population level?
Although OH seems to be a predictor of coronary, cerebrovascular, and HF events, no predictive role was found in models that include biological confounders. Independent of the cause of OH, age and systolic BP, which are positively associated with OH, fully explain the greater incidence of cardiovascular events and the greater cardiovascular risk observed in subjects with OH.
Does human blue-opsin promoter preferentially target reporter gene expression to rat s-cone photoreceptors?
AAV5.HB.GFP vector injected into the subretinal space of Sprague-Dawley rats targeted gene expression to photoreceptor cells with an efficiency approximately 20-fold higher than that for AAV2.HB.GFP. Transgene expression regulated by the human blue cone-promoter persisted at least for 20 months. Cones coexpressing S-opsin and the GFP transgene appeared to prevail, confirming that in addition to having properties of the AAV serotype, the promoter choice is key to fine-tuning transgene delivery and expression in specific retinal cells. The system described here may be effective in a therapeutic setting in which strong S-cone transgene expression is required.
Is intracoronary infusion of progenitor cells associated with aggravated restenosis development or atherosclerotic disease progression in patients with acute myocardial infarction?
In patients with AMI successfully treated with bare metal stent PCI, additional intracoronary progenitor cell infusion does not lead to an increased neointima formation within the implanted stent within 4 months or aggravation of atherosclerotic disease progression.
Does bicluster Sampled Coherence Metric ( BSCM ) provide an accurate environmental context for phenotype predictions?
We demonstrate that the proposed BSCM helps determine which signals ought to be co-clustered, resulting in more accurately assigned bicluster membership. Furthermore, we show that BSCM can be extended to more accurately detect under which experimental conditions the genes are co-clustered. Features derived from this more accurate analysis of conditional regulation results in a dramatic improvement in the ability to predict a cellular phenotype in yeast. The latest cMonkey is available for download at https://github.com/baliga-lab/cmonkey2. The experimental data and source code featured in this paper is available http://AitchisonLab.com/BSCM. BSCM has been incorporated in the official cMonkey release.
Does autophagy limit the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells?
The cytostatic effects of AZ7328 correlate with PIK3CA mutations and are greatly enhanced by dual pathway inhibition using an mTOR inhibitor. Furthermore, AZ7328 can interact with autophagy inhibitors to induce apoptosis in some cell lines. Overall, our results support the further evaluation of combinations of PI3K/AKT/mTOR pathway and autophagy inhibitors in pre-clinical in vivo models and ultimately in patients with PIK3CA mutant bladder cancers.
Does sunitinib enhance neuronal survival in vitro via NF-κB-mediated signaling and expression of cyclooxygenase-2 and inducible nitric oxide synthase?
Sunitinib increases neuronal survival and this neurotrophic effect is mediated by NF-κB. Also, the inflammatory proteins COX2 and NOS2 are upregulated by sunitinib in an NF-κB-dependent manner. These data are in agreement with a growing literature suggesting beneficial effects for inflammatory mediators such as NF-κB, COX2 and NOS2 in neurons. Further work is needed to fully explore the effects of sunitinib in the brain and its possible use as a treatment for glioblastoma. Finally, sunitinib may be useful for the treatment of a range of central nervous system diseases where neuronal injury is prominent.
Do cavernous carotid aneurysms rarely cause subarachnoid hemorrhage or major neurologic morbidity?
CCA is a disorder with strong female gender bias that uncommonly causes major neurologic complications. These data suggest that CCA should not be included in analyses that determine the risk of severe neurologic morbidity, hemorrhage, or death due to intracranial aneurysms.
Is thromboxane-induced contractile response of human coronary arterioles diminished after cardioplegic arrest?
Cardioplegia/Rep decreases the contractile response of human coronary arterioles to TXA-2 soon after cardiac operations. The contractile response to the TXA-2 analog U-46619 is through activation of TXA-2 receptors and PLC.
Does long-term treatment with TGFbeta1 impair mechanotransduction in bovine aortic endothelial cells?
These results indicate that long-term treatment with TGFbeta1 does not impair mechanoreception in BAECs but impairs mechanotransduction by affecting RhoA membrane translocation.
Does surgeon volume predict outcomes in the setting of technical credentialing : results from a randomized trial in colon cancer?
When tested in a randomized controlled trial with case-specific surgical technical credentialing and auditing, surgeon volume did not predict differences in rates of conversion, complications, or long-term cancer outcomes. Case-specific technical credentialing should be further studied specific to the role it could play in creating consistent, high quality outcomes.
Does fTY720 exert differential effects on CD4+ and CD8+ T-lymphocyte subpopulations expressing chemokine and adhesion receptors?
Despite the limited number of patients, especially in the placebo (n = 3) and the high-dose groups (n = 2), our observations suggest that FTY exerts differential effects on T-cell subpopulations. FTY predominantly reduces CD4(+)CD62L(+) cells in the peripheral blood suggesting increased migration into lymph nodes. It seems that only FTY doses above 2 mg are able to reduce peripheral CD4(+)CCR5(+) T lymphocytes, which are potentially capable of infiltrating into the allograft during rejection.
Does live-virus exposure of vaccine-protected macaques alter the anti-HIV-1 antibody repertoire in the absence of viremia?
Anti-Env Ab responses induced by recombinant protein vaccination were altered by the multiple, live SHIV challenges in vaccinees that had no detectable viral loads. These data may have implications for the interpretation of "vaccine only" responses in clinical vaccine trials.
Does model calculations to quantify clinical and economic effects of pathogen inactivation in platelet concentrate?
PI potentially saves plasma, prolongs shelf-life, decreases donor deferral, and reduces ATRs. Model calculations considering clinical and safety benefits of PI show a rational cost increase. The impact of PI should be further evaluated from a societal perspective regarding future blood supply and infectious disease globalization.
Do biological characteristics in bladder cancer depend on the type of genetic instability?
The present observations suggest that there are differences in the biological characteristics of the two types of genetic instability.
Is serum ratio of soluble triggering receptor expressed on myeloid cells-1 to creatinine a useful marker of infectious complications in myeloperoxidase-antineutrophil cytoplasmic antibody-associated renal vasculitis?
The serum ratio of soluble TREM-1 to creatinine may be a useful marker for detection of infectious complications in MPO-ANCA-associated vasculitis.
Does anodal Transcranial Direct Current Stimulation prolong the Cross-education of Strength and Corticomotor Plasticity?
The addition of a-tDCS to the iM1 during unilateral strength training prolongs the benefits of cross-education, which may have significant implications to enhancement of rehabilitation outcomes after a single-limb injury or impairment.
Does bilateral amygdala damage impair the acquisition and use of common ground in social interaction?
These results support the conclusion that the amygdala, a structure critical for social and emotional processing, plays an important role in the acquisition and use of common ground and in social communication more broadly.
Is antibody to S100a6 protein a sensitive immunohistochemical marker for neurothekeoma?
Anti-S100A6 is a highly sensitive antibody for neurothekeomas, including CNT, and, in our experience, is superior in sensitivity to PGP9.5. However, like other antibodies used in evaluating neurothekeomas, S100A6 lacks specificity, as has been demonstrated in previous studies. Nevertheless, S100A6 can be useful in an immunohistochemical antibody panel to evaluate lesions where the differential diagnosis includes CNT.
Is interim 18F-FDG PET SUVmax reduction superior to visual analysis in predicting outcome early in Hodgkin lymphoma patients?
Semiquantitative analysis was more accurate than visual analysis based on the 5-point scale to interpret PET2 and predict the outcome of HL patients. These encouraging results warrant further confirmation in larger and prospective series.
Are different gastritis features linked to different gastric neoplasms?
Our study shows that the (pre)atrophic phases of inflammation are associated with gastric carcinomas. In contrast the active phase of inflammation, characterized by severe activity as well as severe chronicity, is found next to marginal zone cell lymphoma.
Does nitric oxide mediate TNF-α-induced apoptosis in the auditory cell line?
TNF-α can induce apoptosis in the auditory cell line, and NO production in response to TNF-α is essential for apoptosis.
Does glucosamine alleviate scopolamine induced spatial learning and memory deficits in rats?
The results of this study showed that the glucosamine can inhibit scopolamine-induced impairments of spatial learning and memory in rats. Glucosamine might offer a promise in either the prevention or the treatment of neurodegenerative diseases such as Alzheimer's disease.
Does the Selective Sirtuin 1 Activator SRT2104 reduce Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans?
This is the first human study to demonstrate biological anti-inflammatory and anticoagulant responses consistent with the activation of sirtuin 1 by a small molecule.
Does 18F-FDG small-animal PET/CT differentiate trastuzumab-responsive from unresponsive human breast cancer xenografts in athymic mice?
Changes in the tumor uptake of (18)F-FDG after therapy accurately identified responding and nonresponding human BC xenografts in athymic mice treated with trastuzumab; however, diminished glucose utilization did not precede changes in tumor volume.
Are negative illness perceptions associated with new-onset depression following myocardial infarction?
Negative perceptions about heart disease in the days following admission to hospital with first MI are associated with the development of subsequent new episodes of depression.
Does a family harboring homozygous FZD4 deletion support the existence of recessive FZD4-related familial exudative vitreoretinopathy?
The findings in this family support the concept that some mutated FZD4 alleles can be associated with recessive rather than dominant disease.
Is ara h 2 the best predictor for peanut allergy in adults?
sIgE to Ara h 2 has the best discriminative ability of all diagnostic tests. It can accurately diagnose peanut allergy in 28% of patients but cannot be used to exclude a peanut allergy in an adult population.
Do complications after transanal endoscopic microsurgical resection correlate with location of rectal neoplasms?
TEM resection of neoplasms located on the lateral rectal wall have a higher risk of bleeding. The learning curve for transanal endoscopic microsurgery appears to be negligible in surgeons with experience in minimal invasive surgery.
Is compensatory enlargement of human coronary arteries during progression of atherosclerosis unrelated to atheroma burden : serial intravascular ultrasound observations from the REVERSAL trial?
Assessment of coronary arterial remodelling by serial IVUS revealed that compensatory remodelling is not limited by atheroma burden. Atheroma burden is not a determinant of arterial enlargement during the progression of atherosclerosis.
Does copper transporter 2 regulate the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin?
CTR2 is a major determinant of sensitivity to the cytotoxic effects of DDP and CBDCA. CTR2 functions by limiting drug accumulation, and its expression correlates with the sensitivity of human ovarian carcinoma cell lines to DDP.
Is bilirubin exposure associated with neonatal sepsis in the eight days preceding symptoms : a retrospective study?
In our retrospective cohort, we found that the levels of bilirubin and the AUC in the first eight days before the onset of sepsis in preterm infants were significantly higher than the healthy controls. These data suggest that the prolonged exposition to high levels of bilirubin could increase the infection susceptibility in preterm infants.
Does increased expression of urinary matrix metalloproteinases parallel the extent and activity of vascular anomalies?
Expression patterns of hMW MMPs and bFGF in the urine of patients with tumors and malformations are consistent with their different clinical behavior. These data represent the first evidence that MMPs are elevated in the urine of children with vascular anomalies. These data also suggest that the increased expression of urinary MMPs parallels the extent and activity of vascular anomalies in children. In addition to tumors, vascular malformations are angiogenesis dependent, suggesting that progression of a vascular malformation might be suppressed by angiogenic inhibitors, which would target bFGF and MMPs.
Is myopia associated with lower vitamin D status in young adults?
Myopic participants had significantly lower 25(OH)D₃ concentrations. The prevalence of myopia was significantly higher in individuals with vitamin D deficiency compared to the individuals with sufficient levels. Longitudinal studies are warranted to investigate whether higher serum 25(OH)D₃ concentration is protective against myopia or whether it is acting as a proxy for some other biologically effective consequence of sun exposure.
Does adrenaline increase blood-brain-barrier permeability after haemorrhagic cardiac arrest in immature pigs?
Resuscitation with ADR as compared with VAS after haemorrhagic circulatory arrest increased the ICP and impaired cerebrovascular autoregulation more profoundly, as well as exerted an increased BBB disruption though no significant difference in neuronal injury was observed.
Is tissue inhibitor of metalloproteinase-3 a basement membrane-associated protein that is significantly decreased in human colorectal cancer?
These data provide the first detailed description of the cellular expression of tissue inhibitor of metalloproteinase-3 in colorectal cancer and identify it as a basement membrane-associated protein. This is an important observation, because the presence of tissue inhibitor of metalloproteinase-3 protein near the basement membrane supports its role in preventing proteolytic degradation, angiogenesis, and apoptosis.
Does bioelectrical impedance underestimate total and truncal fatness in abdominally obese women?
BIA(8) underestimated both total and truncal fatness, compared with DXA, with higher dispersion for tr%BF than %TBF. The discrepancies increased with degree of adiposity, suggesting that the accuracy of BIA is negatively affected by obesity.
Are serum immunoglobulin free light chain levels higher in girls than boys during eosinophilic oesophagitis?
Our findings suggest that serum TSLP might be a potential marker of EO and TARC of non-EO gastrointestinal food allergies. In EO, serum Ig-fLC appeared higher in females, adding another gender difference to the biology of EO.
Does high-mobility group box 1 potentiate antineutrophil cytoplasmic antibody-inducing neutrophil extracellular traps formation?
HMGB1 can potentiate ANCA-inducing NETs formation and may be involved in the pathogenesis of AAV. HMGB1 exerts effects on NETs formation through interaction with TLR2, TLR4 and RAGE, and the process is NADPH oxidase dependent.
Does arterial occlusion revealed by CT angiography predict NIH stroke score and acute outcomes after IV tPA treatment?
Among patients treated with tPA, those with patent vasculature or occult distal occlusion on CTA before treatment have lower NIHSS, better chances of early improvement and early independence with fewer hemorrhages.
Do peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation?
To our knowledge, this is the first report evidencing quantitatively decreased WNT7A levels in leukemia-derived cells and that WNT7A restoration in T-lymphocytes inhibits cell proliferation. In addition, our results also support the possible function of WNT7A as a tumor suppressor gene as well as a therapeutic tool.
Is exploring the validity of mild cognitive impairment ( MCI ) subtypes : multiple-domain amnestic MCI the only identifiable subtype at longitudinal follow-up?
These findings suggest that the a-MCI+ subtype is the only variant that is recognizable via neuropsychological testing. In contrast, the differentiation between single-domain subtypes and healthy controls is difficult and may not be achievable through current neuropsychological assessment practices.
Do medial amygdala lesions differentially influence stress responsivity and sensorimotor gating in rats?
The present study suggests that the medial amygdala is an important player in response to acute environmental stimuli. Decreased unconditioned psychological stress responses were found, whereas LES was enhanced and sensorimotor processing was disrupted. However, considering the existing data on basolateral amygdala involvement in PPI and bed nucleus of the stria terminalis involvement in LES, local infusion studies into the MeA should be performed to further substantiate these findings.
Is 17q21 gene variation associated with asthma in adulthood?
Our study suggests that the 17q21 rs7216389 locus variant does not substantially influence asthma risk in adulthood or susceptibility to detrimental effects of active smoking. This contrasts the findings in children and suggests that this locus is associated with a childhood-specific asthma endotype.
Do iCSI outcome in patients with transient azoospermia with initially motile or immotile sperm in the ejaculate?
Fertilization and cleavage rates were lower in patients with initially immotile sperm compared with those with initially motile sperm and oligoasthenoteratozoospermia patients. Clinical pregnancy and viable pregnancy rates were not statistically different among groups, although when only immotile sperm were present both clinical pregnancy and live birth rate were lower in comparison with cycles with motile sperm.
Does administration of anti-Reg I and anti-PAPII antibodies worsen pancreatitis?
Administration of anti-Reg/PAP antibody worsened taurocholate-induced organ specific pancreatitis. These data suggest that the Reg family of proteins is protective in acute pancreatitis.
Is an increase in expression of the lipocalin 24p3 found in mouse uterus coincident with birth?
The uterus constitutes a major site of expression of this gene, particularly near birth. The expression of this gene coincident with birth suggests a potential physiologic role of the neutrophil with the induction of labor.
Is tolerability more important than simplicity for treatment durability?
Our findings suggest that STRs do not necessarily result in a more durable treatment. Even with a higher pill burden and/or twice daily dosing, patients initiating therapy with RAL or boosted-PI based regimens were not more likely to discontinue the first-line regimen compared to patients on an STR. Among the STR subgroups, the regimen with better known tolerability conferred more durable treatment. Limitations included our inability to adjust for the patient's adherence to a given regimen.
Does rooming-in improve breastfeeding initiation rates in a community hospital in Puerto Rico?
The advantages offered by the rooming-in practice in the maternity ward of this hospital resulted in successful breastfeeding in this group of mothers.
Does radiation synovectomy using 188Re-tin colloid improve knee synovitis as shown by MRI in refractory rheumatoid arthritis?
Radiation synovectomy using Re-tin colloid in refractory rheumatoid arthritis patients improved MRI findings as well as clinical parameters.
Does use of Medicare claim to rank hospitals by surgical site infection risk following coronary artery bypass graft surgery?
Claims data can identify groups of hospitals with unusually high or low post-CABG SSI rates. Assessment of claims is more reproducible and efficient than current surveillance methods. This example of secondary use of routinely recorded electronic health information to assess quality of care can identify hospitals that may benefit from prevention programs.
Is the number of stroke physicians the key to preparing IV rt-PA?
The number of SPs available may contribute to the management of rt-PA hospitals.
Does the prevalence and correlate of DSM-IV intermittent explosive disorder in the National Comorbidity Survey Replication?
Intermittent explosive disorder is a much more common condition than previously recognized. The early age at onset, significant associations with comorbid mental disorders that have later ages at onset, and low proportion of cases in treatment all make IED a promising target for early detection, outreach, and treatment.