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Does nerve growth factor promote breast cancer angiogenesis by activating multiple pathways?
Our findings provided direct evidence that NGF could be an important stimulator for breast cancer angiogenesis. Thus, NGF, as well as the activated signaling pathways, should be regarded as potential new targets for anti-angiogenic therapy against breast cancer.
Does cardiac-specific overexpression of tumor necrosis factor-alpha cause oxidative stress and contractile dysfunction in mouse diaphragm?
Elevated circulating levels of TNF-alpha provoke contractile dysfunction in the diaphragm through an endocrine mechanism thought to be mediated by oxidative stress.
Are hepatic apoptotic markers predictors for the virological response to interferon-based therapy in chronic hepatitis C patients?
The apoptotic parameters studied in liver tissue are associated with inflammation and fibrosis; however, these parameters may not predict response to treatment.
Does tOF count at corrugator supercilii reflect abdominal muscles relaxation better than at adductor pollicis?
We demonstrated that the TOF response count at the CSC, compared with the AP, allowed a better quantification of the degree of AB muscle relaxation during recovery from vecuronium block.
Are recombination events among virulence genes in malaria parasites associated with G-quadruplex-forming DNA motifs?
Our analyses, conducted at the whole-genome level in multiple species of Plasmodium, support the concept that G4s are likely to be involved in recombination and diversification of antigen-encoding gene families in this important protozoan pathogen.
Does `` Negative vaccination '' by specific CD4 T cell tolerisation enhance virus-specific protective antibody responses?
This result reveals a novel "negative vaccination" strategy where specific CD4+ T cell unresponsiveness may be used to enhance the delayed protective antibody responses in chronic virus infections.
Does zinc-bis-histidinate preserve cardiac function in a porcine model of cardioplegic arrest?
The results of this study support the conclusion that zinc-bis-histidinate is effective as a myocardial preservative when added to a crystalloid cardioplegic solution.
Are apolipoprotein epsilon4 allele and problems with orientation associated with a persistent decline in cognition in community-dwelling elderly persons?
Persistent cognitive decline is an infrequent occurrence in community-dwelling elderly persons. Presence of the epsilon4 allele and errors made by the subject on questions of orientation may be useful in determining whether a cognitive decline is likely to be persistent.
Do sequencing and comparative analysis of fugu protocadherin clusters reveal diversity of protocadherin genes among teleosts?
Our results demonstrate the exceptional evolutionary dynamism of protocadherin genes in vertebrates in general, and in teleost fishes in particular. Besides the 'fish-specific' whole genome duplication, the evolution of protocadherin genes in teleost fishes is influenced by lineage-specific gene losses, tandem gene duplications and regional sequence homogenization. The dynamic protocadherin clusters might have led to the diversification of neural circuitry among teleosts, and contributed to the behavioral and physiological diversity of teleosts.
Does microRNA silencing of tumor suppressor DLC-1 promote efficient hepatitis C virus replication in primary human hepatocytes?
The collective results of this study suggest a novel mechanism of HCV infection-associated miRNA-mediated regulation of a tumor suppressor protein that has the ability to influence cell proliferation and HCV infection-mediated liver cancer.
Are heart failure clinics associated with clinical benefit in both tertiary and community care settings : data from the Improving Cardiovascular Outcomes in Nova Scotia ( ICONS ) registry?
HF clinics are associated with reductions in rehospitalization and mortality in an unselected HF population, independent of whether they are academic- or community-based. Such clinics should be made widely available to the HF population.
Does gene expression-based chemical genomics identify heat-shock protein 90 inhibitors as potential therapeutic drugs in cholangiocarcinoma?
Preclinical data from the current study suggest that NVP-AUY922 may be an effective treatment option for patients with CCA.
Do total IgE levels change 1 year after endoscopic sinus surgery in patients with chronic rhinosinusitis?
The levels of total serum IgE do not change after sinus surgery for chronic rhinosinusitis. IgE levels in chronic rhinosinusitis may reflect a systemic factor in disease pathogenesis, and are probably not related to the amount of local inflammation within the sinuses.
Does cytomegalovirus induce T-cell independent apoptosis in brain during immunodeficiency?
These results indicate that MCMV may cause both direct and indirect pathology to brain and that T-cell independent apoptosis of surrounding cells of the CNS may be an important mechanism of disease in the pathogenesis of neurotropic CMV.
Does chronic cerebral hypoperfusion inhibit calcium-induced long-term potentiation in rats?
Calcium-induced LTP is impaired by chronic cerebral hypoperfusion. This form of LTP is different from that induced by tetanic stimulation. It is the most sensitive test available for in vitro detection of the changes induced in neuronal function by chronic noninfarctional reductions in cerebral blood flow of 25% to 50% and may indicate that the most basic cellular parameters involving calcium homeostasis and metabolism are being altered. The precise mechanisms remain to be elucidated, and several postulates are discussed.
Is increased aortic stiffness persistent in type 1 diabetic women : a follow-up study?
The increased aortic stiffness that affects type 1 diabetic patients seems to be an early event that soon reaches a plateau without any further increase. Increased aortic stiffness in type 1 diabetic women seems to be a sex-specific functional disorder unrelated to the degree of underlying atherosclerosis.
Do pleural and pericardial pressures limit fetal right ventricular output?
The chest wall-lung combination and the pericardium each significantly constrain the fetal RV and together limit RV stroke volume.
Is crohn 's disease associated with novel polymorphisms in the 5'-flanking region of the tumor necrosis factor gene?
Although the findings need to be confirmed in other populations with larger numbers of patients, TNF gene polymorphisms -1031C, -863A, and -857T are positively associated with CD; they may influence not only the susceptibility to CD but also the disease location.
Are microemulsions highly effective anti-biofilm agents?
The results indicate that the microemulsions are highly effective antibiofilm agents.
Do multiple Loci modulate opioid therapy response for cancer pain?
Our results indicate that the identified SNP panel can modulate the response of cancer patients to opioid therapy and may provide a new tool for personalized therapy of cancer pain.
Does fibroblast growth factor 21 action in the brain increase energy expenditure and insulin sensitivity in obese rats?
FGF21 action in the brain increases hepatic insulin sensitivity and metabolic rate in rats with DIO. These findings identify the central nervous system as a potentially important target for the beneficial effects of FGF21 in the treatment of diabetes and obesity.
Does vitamin D repletion alter urinary calcium excretion in healthy postmenopausal women?
Vitamin D supplementation did not increase the urinary calcium excretion in healthy postmenopausal women. Many stone formers are at risk of premature bone loss, vitamin D insufficiency, or both. Based on the present results we suggest a study of patients with hypercalciuria and nephrolithiasis to determine the risks of vitamin D therapy.
Does endothelin-1 activate extracellular signal-regulated kinases 1/2 via transactivation of platelet-derived growth factor receptor in rat L6 myoblasts?
Because activation of ERK1/2 is considered to inhibit differentiation of myoblasts with the development of insulin sensitivity, the ETAR-mediated PDGFR transactivation and subsequent ERK1/2 activation play an important role in ET-1-induced insulin resistance.
Do cerebral hyperperfusion and decreased cerebrovascular reactivity correlate with neurologic disease severity in MELAS?
MELAS disease severity and mutation load were inversely correlated with Interictal CVR and directly correlated with frontal CBF. These metrics offer further insight into the cerebrovascular hemodynamics in MELAS syndrome and may serve as noninvasive prognostic markers to stratify risk for SLEs.
Does stimulatory effect of insulin on glucose uptake by muscle involve the central nervous system in insulin-sensitive mice?
Insulin stimulates glucose uptake in muscle in part through effects via K(ATP) channels in the central nervous system, in analogy with the inhibitory effects of insulin on EGP. High-fat diet-induced obesity abolished the central effects of insulin on liver and muscle. These observations stress the role of central insulin resistance in the pathophysiology of diet-induced insulin resistance.
Are painful and multiple anogenital lesions common in men with Treponema pallidum PCR-positive primary syphilis without herpes simplex virus coinfection : a cross-sectional clinic-based study?
Primary syphilis lesions are often painful and/or multiple in the absence of herpes coinfection, and may be clinically misdiagnosed.
Does overexpression of microRNA-1 impair cardiac contractile function by damaging sarcomere assembly?
miR-1 induces adverse structural remodelling to impair cardiac contractile function. Targeting cMLCK and CaM likely underlies the detrimental effects of miR-1 on structural components of muscles related to the contractile machinery. Our study provides the first evidence that miRNAs cause adverse structural remodelling of the heart.
Does swiprosin-1 regulate Cytokine Expression of Human Mast Cell Line HMC-1 through Actin Remodeling?
These results suggest that swiprosin-1 modulates mast cell activation potentially through actin regulation.
Does the dipeptide Arg-Gln inhibit retinal neovascularization in the mouse model of oxygen-induced retinopathy?
Arg-Gln dramatically inhibited retinal neovascularization in the OIR model. This effect was associated with a reduction in retinal VEGF mRNA levels. Similarly the dipeptide reduced VEGF expression in hRPE cells, a cell type likely to respond to retinal hypoxia by expressing VEGF. Arg-Gln appears to be safe and, with future studies in human infants, may prove beneficial in the prevention of ROP.
Is nonalcoholic fatty liver disease associated with coronary artery calcium score in diabetes patients with higher HbA1c?
This study demonstrated an effect modification of glycemic level on the association between NAFLD and CACS. NAFLD was independently associated with CACS only in diabetes patients with higher HbA1c, after adjustment for confounders.
Does p38/JNK signaling pathway mediate the fluoride-induced down-regulation of Fam83h?
The findings suggest that JNK and P38 could be key regulatory element for Fam83h expression, and that LS8 cells can respond to fluoride by down-regulating Fam83h expression through the regulation of JNK and p38 signaling pathways.
Is the rice ALS3 encoding a novel pentatricopeptide repeat protein required for chloroplast development and seedling growth?
The ASL3 gene encoded a novel chloroplast-targeted PPR protein with 10 tandem PPR motifs in rice. Disruption of the ASL3 would lead to a defective chloroplast and seedling lethality, and affected expression levels of genes associated with chloroplast development and photosynthesis at early leaf stage of rice.
Are characteristics of muscle fiber type predictive of skeletal muscle mass and strength in elderly men?
Skeletal muscle mass and strength in elderly men are positively correlated with muscle fiber type-specific CSA, myonuclear content, and SC content. These findings support the assumption that a decline in SC content plays an important role in age-related decline in muscle mass and strength.
Do total cholesterol and LDL levels decrease before rheumatoid arthritis?
TC and LDL levels and the prevalence of abnormal TC or LDL measures decreased significantly during the 5 years before the RA incidence/index date in patients with RA as compared with the non-RA cohort. These trends in lipid profile in RA are unlikely to be solely due to lipid-lowering treatment.
Do a visual analytics approach for understanding biclustering results from microarray data?
The main visualization technique, tested with different biclustering results on a real dataset, allows researchers to extract interesting features of the biclustering results, especially the highlighting of overlapping zones that usually represent robust groups of genes and/or conditions. The visual analytics methodology will permit biology experts to study biclustering results without inspecting an overwhelming number of biclusters individually.
Does ox-LDL induce PiT-1 expression in human aortic valve interstitial cells?
These data offer mechanistic insight into the pathogenesis of calcific aortic stenosis.
Is the minimum pressure of the lower esophageal sphincter , determined by the rapid pull-through method , an index of severe reflux esophagitis?
This finding would suggest that the minimum LES pressure determined by the RPT method is an index of severe RE.
Are hIV-1 subtype B/B ' and baseline drug resistance mutation associated with virologic failure : a multicenter cohort study in China?
HIV-1 subtype tended to be associated with virologic but not immunologic response; this effect could be ascribed to baseline DRM.
Does adolescent Heavy Drinking Affect Maturation of Basic Executive Functioning : Longitudinal Findings from the TRAILS Study?
Four years of weekly heavy drinking (i.e., chronic heavy drinkers) did not result in measurable impairments in four basic executive functions. Thus, regular heavy drinking in adolescence does not seem to affect these basic behavioural measures of executive functioning.
Is n-terminal pro B-type natriuretic peptide an independent predictor of postoperative myocardial injury in patients undergoing major vascular surgery?
Elevated preoperative plasma NT-pro-BNP levels independently predict postoperative myocardial injury, which is associated with adverse outcome in the short- and long-term regardless of the presence of symptoms of acute coronary syndrome.
Are rho/ROCK and MAPK signaling pathways involved in glioblastoma cell migration and proliferation?
Rho/ROCK signaling is involved in GBM cell migration and proliferation, and this pathway may be linked to ERK signaling.
Do l-type Cav1.3 channels regulate ryanodine receptor-dependent Ca2+ release during sino-atrial node pacemaker activity?
Cav1.3 channels play a critical role in the regulation of [Ca(2+)]i dynamics, providing an unanticipated mechanism for triggering local [Ca(2+)]i releases and thereby controlling pacemaker activity. Our study also provides an additional pathophysiological mechanism for congenital SAN dysfunction and heart block linked to Cav1.3 loss of function in humans.
Are the pathological and molecular but not clinical phenotypes maintained after second passage of experimental atypical bovine spongiform encephalopathy in cattle?
Second passage of H-type and L-type BSE in cattle produced a TSE where the majority of cattle displayed the dull form regardless of clinical disease form of the donor cattle. The pathological and molecular phenotypes of H- and L-type BSE were maintained.
Does pretreatment renal vascular tone predict the effect of specific renin inhibition on natriuresis in essential hypertension?
These data support the hypothesis that in essential hypertension an elevated renal vascular tone is a marker of RAAS-mediated impairment of sodium excretion.
Is intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats prevented by maternal diets enriched in olive oil?
Relevant alterations in cardiac lipid metabolism were evident in the adult offspring of a mild diabetic rat model, and regulated by maternal diets enriched in olive oil.
Is an interleukin-6 gene promoter polymorphism associated with polycystic ovary syndrome in South Indian women?
Our findings showed a significant statistical association between IL-6 -174 G/C SNP and PCOS risk in South Indian women. The 'G' allele frequency influences significantly higher in PCOS patients than controls. However, the exact mechanism by which 'G' allele frequency influence PCOS patients is yet to be determined.
Does pre-infarction angina predict thrombus burden in patients admitted for ST-segment elevation myocardial infarction?
Absence of PIA and proximal culprit lesions are associated with higher thrombus grade. Higher thrombus grade is associated with larger infarct size and slightly worse LV function. This may have clinical implications in planning strategies, particularly regarding pharmacotherapy, that aim to decrease thrombus burden prior to stent implantation.
Is high expression of luteinizing hormone receptors messenger RNA by human cumulus granulosa cells in correlation with decreased fertilization?
The LHR expression in small follicles obtained in IVM suggests a role for hCG administration during IVM procedures. Overexpression of LHR in cumulus GCs of MII oocytes may signal malfunction of oocytes and low fertilization capacity.
Is the obesity gene , TMEM18 , of ancient origin , found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children?
We conclude that TMEM18 is involved in both adult and childhood obesity. It is one of the most conserved human obesity genes and it is found in the majority of all brain sites, including the hypothalamus and the brain stem, but it is not regulated in these regions in classical energy homeostatic models.
Does global population structure of Aspergillus terreus inferred by ISSR typing reveal geographical subclustering?
This study provides evidence of a population structure linked to geographical origin in A. terreus.
Are genetic variations in taste receptors associated with chronic rhinosinusitis : a replication study?
This study replicates previous work which showed that the coding SNP rs10246939 in the TAS2R38 gene is associated with CRS. Moreover, the results suggest that other taste receptors may be implicated in CRS. Further studies using individual genotyping and sequencing, and functional studies will provide more information about the implication of these genetic variants in CRS.
Does interferon-alpha prevent selection of doxorubicin-resistant undifferentiated-androgen-insensitive metastatic human prostate cancer cells?
Treatment with IFN-alpha and DOX should be further explored as a therapeutic strategy for androgen-insensitive prostate cancer.
Are glycated hemoglobin levels mostly dependent on nonglycemic parameters in 9398 Finnish men without diabetes?
The variance in HbA1c among men without type 2 diabetes was largely determined by nonglycemic factors and only weakly by impaired insulin sensitivity and insulin secretion.
Does self-efficacy correlate with leg muscle pain during maximal and submaximal cycling exercise?
Our data provided evidence that self-efficacy for tolerating moderate to strong muscle pain during exercise correlates with muscle pain intensity ratings during bouts of maximal and submaximal exercise. Future research could identify methods of manipulating self-efficacy as a means of decreasing muscle pain during exercise and ultimately enhancing physical activity participation.
Does antigen-receptor cross-linking induce peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice?
Self-reactive B cells are eliminated by the binding of antigen at both mature and immature stages. B-cell activation appears to require, in addition to antigen binding, a second signal that induces expression of rescue molecules such as the bcl-2 gene product. Resistance to B-cell apoptosis induced by antigen receptor cross-linking may play a crucial role in the production of autoantibodies and in the pathogenesis of the autoimmune diseases found in the strains of mice used here.
Does lactobacillus fermentum BCS87 express mucus- and mucin-binding proteins on the cell surface?
Adhesion of Lact. fermentum BCS87 appeared to be mediated by two surface-associated proteins. 32-Mmubp is a component of ABC transporter system that also functions as an adhesin.
Do primary implant placement with evisceration in patients with endophthalmitis?
Primary orbital implant placement with evisceration in patients with endophthalmitis is an acceptable treatment, eliminating the need for open evisceration and subsequent delayed orbital implant placement.
Does comparison of LCD and CRT display based on efficacy for digital mammography?
This study explored the suitability of two different soft-copy displays for the viewing of mammographic images. It found that LCD and CRT displays offer similar clinical utility for mammographic tasks.
Is foxO3a Essential for the Antiproliferative and Apoptogenic Effects of Sunitinib in MDA-MB231 Cell Line?
SUN inhibits TNBC MDA-MB231 cell proliferation through activation of FOXO3a expression.
Do consumers report lower confidence in their genetics knowledge following direct-to-consumer personal genomic testing?
Lowered genetics self-efficacy following PGT may reflect an appropriate reevaluation by consumers in response to receiving complex genetic information.Genet Med 18 1, 65-72.
Does sPECT improve accuracy of somatostatin receptor scintigraphy in abdominal carcinoid tumors?
Indium-111-pentetreotide scintigraphy is a safe and practical procedure. SPECT appears to be more sensitive than planar scintigraphy and conventional methods to detect abdominal carcinoids; it can increase the number of visualized tumor sites and that of patients with positive findings and may therefore have a role not only in the mapping of tumor spread but also in therapeutic decisions.
Are serum lipoprotein ( a ) concentrations related to coronary disease progression without new myocardial infarction?
Serum lipoprotein(a) concentrations are closely related to the progression of coronary artery disease without new myocardial infarction. Lipoprotein(a) lowering treatment may be needed to prevent disease progression in patients with coronary artery disease and high serum lipoprotein(a).
Does [ NP9 gene inhibit tumorigenicity of nasopharyngeal carcinoma ]?
NP9 inhibits tumorigenicity and growth of NPC transplanted tumor by down-regulating the expression of cyclin D1 and PCNA.
Are ki-ras gene mutations , LOH of the APC and DCC genes , and microsatellite instability in primary colorectal carcinoma associated with micrometastases in pericolonic lymph nodes or with patients ' survival?
There are insufficient data to justify using molecular genetic changes in primary colorectal carcinomas as prognostic markers. Micrometastases do not provide prognostic information on survival. There is value in increasing the numbers of lymph nodes removed and analysed along with the primary tumour.
Does continuous arteriovenous hemofiltration improve survival in a canine model of septic shock?
The results of this study suggest that CAVH would be unlikely to provide benefit to patients with gram-negative septic shock, in the absence of renal failure.
Do topical calcineurin inhibitors decrease the production of UVB-induced thymine dimers from hairless mouse epidermis?
Taken together, these results suggest that topical calcineurin inhibitors prevent DNA photodamage due to a filter effect of both vehicle and active components, whereas they do not affect the clearance of DNA photoproducts.
Does arg-gly-asp-mannose-6-phosphate inhibit activation and proliferation of hepatic stellate cells in vitro?
The new compound, RGD-M6P, which has a dramatic effect on primary cultured HSCs in vitro, can inhibit the transformation of HSCs in culture caused by TGFbeta1, suppresses the expression of PC III and decreases proliferation rate of HSC. RGD-M6P can be applied as a selective drug carrier targeting at HSCs, which may be a new approach to the prevention and treatment of liver fibrosis.
Is the ratio of the absolute lymphocyte count to the absolute monocyte count associated with prognosis in Hodgkin 's lymphoma : correlation with tumor-associated macrophages?
This study suggests that the ALC/AMC ratio may be a simple, inexpensive, and independent prognostic factor for OS outcome in patients with cHL and may have a role in the stratification of cHL patients in addition to the International Prognostic Score and TAM content.
Does levodopa dosage determine adherence to long-acting dopamine agonists in Parkinson 's disease?
In levodopa-treated PD patients, adherence to ODDA therapy is suboptimal and strongly associated with the levodopa daily dose and the total number of drugs used to treat patients' medical conditions.
Does extraction ( DSX ) from Erigeron breviscapus modulate outward potassium currents in rat retinal ganglion cells?
These results suggest that DSX reversibly and dose-dependently suppress outward K(+) channel currents in rat RGCs, which may be one of the possible mechanisms underlying Erigeron breviscapus prevents vision loss and RGC damage caused by glaucoma.
Are polymorphisms in the SERPINA1 ( Alpha-1-Antitrypsin ) gene associated with severe chronic rhinosinusitis unresponsive to medical therapy?
Polymorphisms of the SERPINA1 gene are associated with clinically severe CRS. These results, from a small subset of individuals with CRS, suggest that defects in AAT may be implicated in a subset of individuals unresponsive to conventional therapy and suggests that alternate therapies may be required for their management.
Does adrenomedullin require an intact nitric oxide system to function as an endogenous vasodilator in rat gestation?
Addition of the endogenous vasodilator AM to an L-NAME-induced state of chronic NO inhibition did not ameliorate hypertension and growth restriction.
Does high bias gas flow increase lung injury in the ventilated preterm lamb?
High ventilator bias gas flows resulted in increased lung injury, with up-regulation of acute early response genes and increased histological lung injury. Bias gas flows may, therefore, contribute to VILI and BPD.
Does kidney function before pancreas transplant alone predict subsequent risk of end-stage renal disease?
Kidney function before PTA is a strong independent predictor of ESRD. These results may inform patient selection and the use of targeted interventions to reduce the risk of progressive kidney impairment in this patient population.
Does deferasirox induce regression of iron overload in patients with myelodysplastic syndromes?
Our data show that treatment with deferasirox is a reasonable approach to counteract iron overload in patients with MDS.
Is the E3 ubiquitin ligase Hace1 required for early embryonic development in Xenopus laevis?
Our results suggest that Xenopus laevis hace1 plays an important role in early embryonic development, possibly via regulation of Rac1 activity.
Is hypomethylation restricted to the D4Z4 repeat array in phenotypic FSHD?
Our data suggest that in phenotypic FSHD hypomethylation is restricted to D4Z4 and that phenotypic FSHD and ICF do not share a defect in the same molecular pathway.
Is l1 cell adhesion molecule a novel therapeutic target in intrahepatic cholangiocarcinoma?
We identified that L1 is expressed in ICC. L1 plays an important role in the tumor progression of ICC by enhancing cell proliferation, migration, invasion, and survival. L1 may represent a novel therapeutic target for ICC.
Does inhibition of integrin function by a cyclic RGD-containing peptide prevent neointima formation?
Inhibition of integrin function by an RGD-containing peptide results in reduction of the development of a neointima. This effect is due both to an early event, which could be due to inhibition of secretion of PDGF by the platelets with blocked alpha IIb beta 3, and to a late event, possibly by interference with smooth muscle cell alpha v beta 3.
Does low-dose radiation induce renal SOD1 expression and activity in type 1 diabetic mice?
The stimulation of renal SOD1 expression and activity by a single or cumulative LDR of 75 mGy may be one of the preventive mechanisms of DN observed in the previous study.
Is orexin-A Associated with Increases in Cerebrospinal Fluid Phosphorylated-Tau in Cognitively Normal Elderly Subjects?
Orexin-A is associated with increased P-Tau in normal elderly individuals. Increases in orexin-A and P-Tau might be a consequence of the reduction in the proportion of the deeper, more restorative slow wave sleep and rapid eye movement sleep reported with aging.
Does renal power Doppler ultrasound predict renal scarring after urinary tract infection?
RPD offered no advantage over ultrasound to predict renal scarring and cannot be recommended to predict renal scarring following UTI.
Does concomitant use of azathioprine/6-mercaptopurine decrease the risk of anti-TNF-induced skin lesions?
Concomitant use of AZA/6 MP may decrease the occurrence of adverse skin lesions in patients receiving anti-TNF therapy.
Is radiographic measurement of the posterior femoral offset precise?
The conventional radiologic technique for the measurement of the posterior femoral offset cannot be reliably used either for pre-TKA planning of the posterior femoral resection and antero-posterior sizing of the femoral component, or for post-TKA quality control of the reconstruction of the posterior femoral offset.
Do long-term resolution of immunological graft rejection after a dexamethasone intravitreal implant?
In 4 eyes with an immunologic graft rejection after penetrating keratoplasty, the dexamethasone 0.7 mg intravitreal implant was an effective treatment option, even in cases refractory to standard topical and systemic therapy.
Do cytokeratin deposits in lymph nodes show distinct clinical significance from lymph node micrometastasis in human esophageal cancers?
Evaluation by cytokeratin immunostaining of lymph nodes requires careful discrimination of CD from MM, in order to allow MM to be used as a prognostic factor for esophageal cancer patients.
Do why renal nurses cope so well with their workplace stressors?
Assisting nurses to use emotional distancing, rather than emotional detachment strategies to engender a sense of personal achievement may promote resilience.
Does inhibition of long-chain acyl coenzyme A synthetases during fatty acid loading induce lipotoxicity in macrophages?
Inhibition of ACSLs during fatty acid loading results in apoptosis via accumulation of FFAs. Our data have implications in understanding the consequences of dysregulated fatty acid metabolism in macrophages.
Does expression of matrix metalloproteinase-9 correlate with poor prognosis in human malignant fibrous histiocytoma?
Our data demonstrate that MMP-9 activation is likely to occur in human malignant fibrous histiocytomas. It is also noteworthy that the expression of MMP-9 may aid in predicting patients' poor prognosis.
Do cD34+ cells represent highly functional endothelial progenitor cells in murine bone marrow?
These findings suggest that mouse CD34(+) cells may represent a functional EPC population in bone marrow, which could benefit the investigation of therapeutic EPC biology.
Do rod outer segments mediate mitochondrial DNA damage and apoptosis in human retinal pigment epithelium?
Exposure of ROS to ROS induced mtDNA damage and dysfunction and activated nDNA repair pathways, which did not prevent apoptosis.
Is electroconvulsive therapy equally effective in unipolar and bipolar depression?
Both UP and BP depressions remit with ECT. Polarity is not a factor in the response rate. In this sample ECT did not precipitate mania in depressed patients. Treatment algorithms for UP and BP depression warrant re-evaluation.
Does presence of pore and vacuoles in set endodontic sealers?
Pores and vacuoles were a consistent finding in set sealers. Their frequency and size depended on the density of the sealer and increased when the sealers contained calcium hydroxide.
Are regression discontinuity designs underutilized in medicine , epidemiology , and public health : a review of current and best practice?
Increased use of RD provides an exciting opportunity for obtaining unbiased causal effect estimates when experiments are not feasible or when we want to evaluate programs under "real-life" conditions. Although treatment eligibility in medicine, epidemiology, and public health is commonly determined by threshold rules, use of RD in these fields has been very limited until now.
Are personality traits differentially associated with patterns of reward and novelty processing in the human substantia nigra/ventral tegmental area?
SN/VTA responses to novelty and reward are differentially affected by personality traits of novelty-seeking and reward-dependence. Importantly, novelty-seekers were more responsive to novel cues in the absence of reward and needed less reward to boost their memory for novel cues. These observations strongly suggest that for novelty-seekers, the motivational value of novelty is not necessarily based on actual reward-predicting stimulus properties.
Is the activation of natural killer cell effector functions by cetuximab-coated , epidermal growth factor receptor positive tumor cells enhanced by cytokines?
These results show that cetuximab-mediated NK cell activity can be significantly enhanced in the presence of NK cell-stimulatory cytokines. These factors, therefore, may be effective adjuvants to administer, in combination with cetuximab, to patients with HER1-positive malignancies.
Does low-intensity exercise training improve survival in Dahl salt hypertension?
These data suggest that exercise training is an important intervention for salt-sensitive hypertension and that the enhanced survival observed with exercise training appears to be independent of training-induced SBP lowering effects.
Does rTMS over the cerebellum modulate temperature detection and pain thresholds through peripheral mechanisms?
Our findings suggest that changes in sensory perception after rTMS over the cerebellum are largely due to stimulation effects on peripheral structures and support recent reports of analgesic effects of neck rMS. They advocate the critical review of the proposed analgesic effects of rTMS and encourage the future use of proper control conditions in rTMS research.
Does cephalometric Angular Measurements of the Mandible Using Three-Dimensional Computed Tomography scan in Koreans?
These results provide an average of the mandibular angular measurements for the Korean population, establishing a standard for determining surgical patient groups and outcome evaluations in the field of mandible contour surgery.
Does dCP-LA activate Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain?
Unlike PMA DCP-LA activates cytosolic PKCε by binding to the phosphatidylserine binding/associating sites Arg50 and Ile89, possibly at the carboxyl-terminal end and the cyclopropane rings, respectively.