manufernandezbur/uniprot2025_03 · Datasets at Fast360

400

A0A2K5QCI5

MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDSVKDSGRDYVSQFESSALGKQLNLKLLDNWDSLTSTVNKLREDLGPVTQEFWDNLEKETGWLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEVKLYSQKLEPLRTEFQEGALQKLQDLQEKLSPLAEQVRDRARAHVDTLRTQLAPYSDELRQRLATRLEVLKESGGASLAEYHAKASEHLSALGEKAKPALEDLRQGLLPVLESFKVSFLSALEEYAKKLSSQ

Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I]

Cebus imitator (Panamanian white-faced capuchin) (Cebus capucinus imitator)

2,715,852

267

30,548

Cholesterol metabolism;HDL;Lipid metabolism;Lipid transport;Lipoprotein;Oxidation;Palmitate;Phosphoprotein;Reference proteome;Repeat;Secreted;Signal;Steroid metabolism;Sterol metabolism;Transport

GO:0001540; GO:0001935; GO:0002719; GO:0005543; GO:0006656; GO:0006695; GO:0007186; GO:0007229; GO:0008035; GO:0008211; GO:0010804; GO:0010875; GO:0010903; GO:0015485; GO:0019899; GO:0019915; GO:0030139; GO:0030300; GO:0030325; GO:0031072; GO:0032489; GO:0032691; GO:0033344; GO:0033700; GO:0034115; GO:0034191; GO:0034205; GO:0034361; GO:0034362; GO:0034366; GO:0034375; GO:0034380; GO:0035025; GO:0042158; GO:0042627; GO:0042632; GO:0042803; GO:0043534; GO:0043691; GO:0045499; GO:0050728; GO:0050766; GO:0050821; GO:0051180; GO:0051496; GO:0055091; GO:0060228; GO:0060354; GO:0070328; GO:0070508; GO:0070653; GO:0071402; GO:0090205; GO:0120020; GO:1900026; GO:1902995; GO:1903561

Inferred from homology

5

SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02647}.

SIGNAL 1..18; /evidence="ECO:0000255"

null

PF01442;

IPR000074;IPR050163;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Mammalia (class), Theria (clade), Eutheria (clade), Boreoeutheria (clade), Euarchontoglires (superorder), Primates (order), Haplorrhini (suborder), Simiiformes (infraorder), Platyrrhini (parvorder), Cebidae (family), Cebinae (subfamily), Cebus (genus)

APOA1

false

401

A0A2K5TU92

MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSHVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPHVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGSCLEPCAQHNGSEPASPKRERPTSPAPNRPPKRVKAEAVPS

NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-)

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

9,541

355

39,078

Acetylation;Acyltransferase;Chromatin regulator;Chromosome;Developmental protein;DNA damage;DNA repair;DNA-binding;Endoplasmic reticulum;Glycosyltransferase;Isopeptide bond;Metal-binding;NAD;Nucleotidyltransferase;Nucleus;Phosphoprotein;Reference proteome;RNA-binding;Telomere;Transferase;Tumor suppressor;Ubl conjugation;Zinc

GO:0000122; GO:0000785; GO:0003684; GO:0003714; GO:0005634; GO:0005654; GO:0005721; GO:0005783; GO:0006302; GO:0006606; GO:0008340; GO:0009411; GO:0010526; GO:0010569; GO:0016779; GO:0019216; GO:0030182; GO:0031490; GO:0031491; GO:0031508; GO:0031509; GO:0031648; GO:0032024; GO:0032206; GO:0032436; GO:0032922; GO:0034244; GO:0034979; GO:0035033; GO:0035861; GO:0042181; GO:0042308; GO:0042752; GO:0042803; GO:0045600; GO:0045721; GO:0045820; GO:0046827; GO:0046872; GO:0046969; GO:0050994; GO:0051697; GO:0055007; GO:0070403; GO:0097372; GO:0099115; GO:0106222; GO:0106274; GO:0120162; GO:0120186; GO:0120187; GO:0140612; GO:0140765; GO:0140773; GO:0140774; GO:1902459; GO:1902732; GO:1903076; GO:1904841; GO:1905555; GO:1905564; GO:1990166; GO:2000738; GO:2000773; GO:2000781

Evidence at protein level

5

SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P59941}. Chromosome {ECO:0000250|UniProtKB:Q8N6T7}. Chromosome, telomere {ECO:0000250|UniProtKB:Q8N6T7}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P59941}. Note=Predominantly nuclear. Associated with pericentric heterochromatin and telomeric heterochromatin regions. Localizes to DNA damage sites: directly recognizes and binds double-strand breaks (DSBs) sites via a tunnel-like structure that has high affinity for DSBs (By similarity). A fraction localizes to the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P59941, ECO:0000250|UniProtKB:Q8N6T7}.

null

PF02146;

IPR029035;IPR050134;IPR003000;IPR026590;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Mammalia (class), Theria (clade), Eutheria (clade), Boreoeutheria (clade), Euarchontoglires (superorder), Primates (order), Haplorrhini (suborder), Simiiformes (infraorder), Catarrhini (parvorder), Cercopithecoidea (superfamily), Cercopithecidae (family), Cercopithecinae (subfamily), Macaca (genus)

SIRT6

false

402

A0A2K6TRM6

MKAVVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDSVKESGKDYVSQFETSALGKQLNLKLLDNWDSLTSTVNKLREQLGPVTQEFWDNLEKETEQLRQEMNKDLEEVKAKVQPYLDDFQKKWQEEMNLYSQKLEPLRTEFQEGAFQKLQDLREKLRPVAEQVRDRARAHVDTLRTQLAPYSDELRQRLATRLEALKESGATLAEYQAKASEHLSALGEKAKPAFEDLRQGLLPVLESFKVSFLSALDEYAKKLSSQ

Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I]

Saimiri boliviensis boliviensis (Bolivian squirrel monkey)

39,432

266

30,705

Cholesterol metabolism;HDL;Lipid metabolism;Lipid transport;Lipoprotein;Oxidation;Palmitate;Phosphoprotein;Reference proteome;Repeat;Secreted;Signal;Steroid metabolism;Sterol metabolism;Transport

GO:0001540; GO:0001935; GO:0002719; GO:0005543; GO:0006656; GO:0006695; GO:0007186; GO:0007229; GO:0008035; GO:0008211; GO:0010804; GO:0010875; GO:0010903; GO:0015485; GO:0019899; GO:0019915; GO:0030139; GO:0030300; GO:0030325; GO:0031072; GO:0032489; GO:0032691; GO:0033344; GO:0033700; GO:0034115; GO:0034191; GO:0034205; GO:0034361; GO:0034362; GO:0034366; GO:0034375; GO:0034380; GO:0035025; GO:0042158; GO:0042627; GO:0042632; GO:0042803; GO:0043534; GO:0043691; GO:0045499; GO:0050728; GO:0050766; GO:0050821; GO:0051180; GO:0051496; GO:0055091; GO:0060228; GO:0060354; GO:0070328; GO:0070508; GO:0070653; GO:0071402; GO:0090205; GO:0120020; GO:1900026; GO:1902995; GO:1903561

Inferred from homology

5

SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02647}.

SIGNAL 1..18; /evidence="ECO:0000255"

null

PF01442;

IPR000074;IPR050163;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Mammalia (class), Theria (clade), Eutheria (clade), Boreoeutheria (clade), Euarchontoglires (superorder), Primates (order), Haplorrhini (suborder), Simiiformes (infraorder), Platyrrhini (parvorder), Cebidae (family), Saimiriinae (subfamily), Saimiri (genus), Saimiri boliviensis (species)

APOA1

false

403

A0A2K8FQU5

MASKMVEIVSKMFIKPSSPTPQSLRRYNLSSIDQTIDSEVTSLAFFYTYNPSHESSKIGDLLKNSLSKTLVSYYQFAGRLIENDYIDCNDEGVEFVEVRIHGRMNDILKRGKSFATDLVLPTRIIALHEDSLLIVQLSHFDCGGIAIGFGASHKVSDGVSNVMFMKDWASSTSLSTFHKPTPLLTADSIFPPEDNKLLSNKSIVSFQQCLGKRFVFSTEAIEKLKSKAIEYGIQKPSRVEVVTAFLCQCAANCDLPRKKPYAIISAVNLRPYLALPQNSIGNIFSFYFCINDEGMDNQFSALISKLRNGKQKLLENIISKEKLTYESQMQELTKCLDQLNISSLDTYFCSSWCRFPVYDIDFGWGKPILVSPFQPHVKDLILLMDSPEGDGIEALITMEEKKMAAFEKNEELRSFAYLDSPEPEALIIPEEDKSFE

Tabersonine-19-hydroxy-O-acetyltransferase (EC 2.3.1.-)

Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)

4,058

436

49,141

Acyltransferase;Alkaloid metabolism;Cytoplasm;Nucleus;Transferase

GO:0005634; GO:0005737; GO:0009753; GO:0016407; GO:0035835

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29438577}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:29438577}.

null

PF02458;

IPR023213;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), lamiids (clade), Gentianales (order), Apocynaceae (family), Rauvolfioideae (subfamily), Vinceae (tribe), Catharanthinae (subtribe), Catharanthus (genus)

TAT

false

404

A0A2K9RFZ2

MSLRFNLIVTPFSNHRIRNRRETFPAQEFPVATSKSAVKVKCNLITSTDLVGKVREKINGKVDNSLEVPAIHPVDIPSNLCMIDTLERLGVDRYFQSEIDGVLEETYRLWQQKEKDIFADVTCRAMAFRLLRVKGYEVSSDELAPYADQAHVNLQISDVTAVIELYRASQERIYEEESTLEKLHAWTSTYLKQQLVSGTISDKKLHKQVEYYLKNYHGILDLVGIRRSLDLYDIDHYQILKAADRFRTICKDLLAFSRQDFNNCQAQYQRELQLLQRWYEDCRLDKLNYGRDVLRISYFVSSAIIGDPELSDARLAFAKYCVLTTCIDDFFDHAGSREESYRILELVKEWKEKPAEDYGSKEVEFLFTAVYNTVNELAEMAYVEQGRCVKSLLIKLWVELLTSFKKELDSWTDDTALSLDEYLSSSWVSITSRINILTSIQFLGLKLSEEMLSSQECTDLCRHGSLVVRLLNDMQTFEKERRENTKNSVSILLEAPKHEGAITEEEVISKIKEIVEQNRRKLMQMVYQRGTIFPRKCKDVFLKSCRGGYYLYSNGDEFTSPVQIMEDMKLCYEPLTFHPLEANNGGNKN

Class I diterpene synthase 2, chloroplastic (VacTPS2) ((13S)-vitexifolin A synthase) (EC 4.2.3.-) (9,13-epoxylabda-14-ene synthase) (EC 4.2.3.189) (Viteagnusin D synthase) (EC 4.2.3.-)

Vitex agnus-castus (Chaste tree)

54,477

589

68,332

Chloroplast;Lyase;Magnesium;Metal-binding;Plastid;Transit peptide

GO:0000287; GO:0009507; GO:0009686; GO:0010333; GO:0062203; GO:0062204; GO:0106239

Evidence at protein level

5

SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000255}.

null

PF01397;PF03936;

IPR008949;IPR001906;IPR036965;IPR050148;IPR005630;IPR008930;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), lamiids (clade), Lamiales (order), Lamiaceae (family), Viticoideae (subfamily), Vitex (genus)

TPS2

false

405

A0A2L0VXR5

MRIPNVFLSYLRQVAVDGTLSSCSGVKSRKPVIAYGFDDSQDSLVDENDEKILEPFGYYRHLLKGKSARTVLMHCFNAFLGLPEDWVIGVTKAIEDLHNASLLIDDIEDESALRRGSPAAHMKYGIALTMNAGNLVYFTVLQDVYDLGMKTGGTQVANAMARIYTEEMIELHRGQGIEIWWRDQRSPPSVDQYIHMLEQKTGGLLRLGVRLLQCHPGVNNRADLSDIALRIGVYYQLRDDYINLMSTSYHDERGFAEDMTEGKYTFPMLHSLKRSPDSGLREILDLKPADIALKKKAIAIMQDTGSLVATRNLLGAVKNDLSGLVAEQRGDDYAMSAGLERFLEKLYIAE

Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (GGS) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10) (Pleuromutilin biosynthetic cluster protein synthesis protein G)

Clitopilus passeckerianus (Pleurotus passeckerianus)

648,682

350

39,229

Antibiotic biosynthesis;Isoprene biosynthesis;Magnesium;Metal-binding;Transferase

GO:0004161; GO:0004311; GO:0004337; GO:0016114; GO:0017000; GO:0046872

Evidence at transcript level

5

null

PF00348;

IPR008949;IPR000092;IPR033749;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Basidiomycota (phylum), Agaricomycotina (subphylum), Agaricomycetes (class), Agaricomycetidae (subclass), Agaricales (order), Tricholomatineae (suborder), Entolomataceae (family), Clitopilus (genus)

GGPS ggs

false

406

A0A2L2DDD0

MAFLKKSLFLVLFLGIVSLSVCEEEKREGEEKEEKREEEEGKEENEDGNEEHKEKRFLGAILKIGHALAKTVLPMVTNAFKPKQ

Figainin 2 (Br22)

Boana raniceps (Chaco tree frog) (Hyla roeschmanni)

192,750

84

9,632

Amphibian defense peptide;Antibiotic;Antimicrobial;Antiviral protein;Cleavage on pair of basic residues;Cytolysis;Direct protein sequencing;Hemolysis;Immunity;Innate immunity;Secreted;Signal

GO:0005576; GO:0042832; GO:0044179; GO:0045087; GO:0050688; GO:0050829; GO:0050830; GO:0051607

Evidence at protein level

5

SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32443921}.

SIGNAL 1..22; /evidence="ECO:0000255"

null

PF03032;

IPR004275;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amphibia (class), Batrachia (superorder), Anura (order), Neobatrachia (suborder), Hyloidea (superfamily), Hylidae (family), Hylinae (subfamily), Cophomantini (tribe), Boana (genus)

null

false

407

A0A2L2DDE6

MAFLKKSLFLVLFLGLVSLSIGEEEKREEEEKNEEGANQEENAENKEKRFIGTLIPLALGALTKLFKG

Figainin 1 (Br24)

Boana raniceps (Chaco tree frog) (Hyla roeschmanni)

192,750

68

7,640

Amidation;Amphibian defense peptide;Antibiotic;Antimicrobial;Cleavage on pair of basic residues;Cytolysis;Direct protein sequencing;Hemolysis;Immunity;Innate immunity;Secreted;Signal

GO:0005576; GO:0042832; GO:0044179; GO:0045087; GO:0050829; GO:0050830

Evidence at protein level

5

SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32967114}.

SIGNAL 1..22; /evidence="ECO:0000255"

null

PF03032;

IPR004275;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amphibia (class), Batrachia (superorder), Anura (order), Neobatrachia (suborder), Hyloidea (superfamily), Hylidae (family), Hylinae (subfamily), Cophomantini (tribe), Boana (genus)

null

false

408

A0A2N6JFX7

MIRIDATPYPYQFHPRSTALVVIDMQRDFIEEGGFGSALGNDVRPLAAIVPTVAALLQLAREAGMLVVHTRESHLPDLSDCPRSKRLRGNPTLGIGDVGPMGRILVQGEPGNQILPQLAPVEGELVIDKPGKGAFYATDLHAQLQERRITHLLVAGVTTEVCVQTSMREANDRGYECLVIEDACASYFPDFHRITLEMLTAQGGIVGWRTPLAQLQAGVAAYTGENP

Triuret hydrolase TrtA (EC 3.5.1.-) (Cysteine hydrolase)

Herbaspirillum sp. (strain BH-1)

2,058,884

227

24,638

3D-structure;Hydrolase

GO:0016811; GO:0042802; GO:0042803; GO:0043605

Evidence at protein level

5

null

PF00857;

IPR000868;IPR050272;IPR036380;

6XIX;6XJ4;6XJE;

cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Betaproteobacteria (class), Burkholderiales (order), Oxalobacteraceae (family), Herbaspirillum (genus), unclassified Herbaspirillum (no rank)

trtA HBH1_00246

false

409

A0A2P1GIW2

MNSSTDPTSDETIWDLSPYIKIFKDGRVERLHNSPYVPPSLNDPETGVSWKDVPISSQVSARVYIPKISDHEKLPIFVYVHGAGFCLESAFRSFFHTFVKHFVAETKVIGVSIEYRLAPEHLLPAAYEDCWEALQWVASHVGLDNSGLKTAIDKDPWIINYGDFDRLYLAGDSPGANIVHNTLIRAGKEKLKGGVKILGAILYYPYFIIPTSTKLSDDFEYNYTCYWKLAYPNAPGGMNNPMINPIAENAPDLAGYGCSRLLVTLVSMISTTPDETKDINAVYIEALEKSGWKGELEVADFDADYFELFTLETEMGKNMFRRLASFIKHE

Catharanthine synthase (EC 5.5.1.37) (Hydrolase 1) (CrHL1)

Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)

4,058

330

37,132

3D-structure;Alkaloid metabolism;Cytoplasm;Isomerase;Nucleus

GO:0005634; GO:0005829; GO:0009821; GO:0016787; GO:0016853; GO:0035834

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:29724909}. Nucleus {ECO:0000269|PubMed:29724909}.

null

PF07859;

IPR013094;IPR029058;IPR050466;

6RT8;

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), lamiids (clade), Gentianales (order), Apocynaceae (family), Rauvolfioideae (subfamily), Vinceae (tribe), Catharanthinae (subtribe), Catharanthus (genus)

CS HL1 Caros025416

false

410

A0A2P1GIW3

MGSSDETIFDLPPYIKVFKDGRVERLHSSPYVPPSLNDPETGGVSWKDVPISSVVSARIYLPKINNHDEKLPIIVYFHGAGFCLESAFKSFFHTYVKHFVAEAKAIAVSVEFRLAPENHLPAAYEDCWEALQWVASHVGLDISSLKTCIDKDPWIINYADFDRLYLWGDSTGANIVHNTLIRSGKEKLNGGKVKILGAILYYPYFLIRTSSKQSDYMENEYRSYWKLAYPDAPGGNDNPMINPTAENAPDLAGYGCSRLLISMVADEARDITLLYIDALEKSGWKGELDVADFDKQYFELFEMETEVAKNMLRRLASFIK

Tabersonine synthase (EC 5.5.1.38) (2-hydroxyisoflavanone dehydratase-like protein 3) (CrHID3) (HID-like protein 3) (Hydrolase 2) (CrHL2)

Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)

4,058

320

36,192

3D-structure;Alkaloid metabolism;Cytoplasm;Isomerase;Lyase;Nucleus

GO:0005634; GO:0005829; GO:0009821; GO:0016787; GO:0016829; GO:0016853; GO:0035834

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:29724909}. Nucleus {ECO:0000269|PubMed:29724909}.

null

PF07859;

IPR013094;IPR029058;IPR050466;

6RS4;

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), lamiids (clade), Gentianales (order), Apocynaceae (family), Rauvolfioideae (subfamily), Vinceae (tribe), Catharanthinae (subtribe), Catharanthus (genus)

TS HID3 HL2

false

411

A0A2P2GK84

MNASPTPTATTTTEPATAVVRCRTRLARRVVAAVGPDGLLPAPCESRVLESALALALLTEERAEADATARLTAYLRTTLRTAPPDPFQCAVARAVLGGAGERGERVGDEGDMDAGTALDAGLDGFDHFTAGRKRLMFRTVLAALGATGFPAVPWEAYDTRPQQSWLHMEMKALKVLAAHGTGHPDVVRDEDWRALLPALEPGPAWECNNLAQLLALLALRHSPRHRPALGDVLKHVAGRLRPDGGMPFIDGMTVFTTAAAGLALSLLPAPPACVTPMADALALRRNPDGGYGFHSGVAQSDVDDTCYVLEFLRRAAPDRHRTAVAEAEGYLLALRNPDGGFPTFARGTSSEIAMTAAAASALAHDPDRREEVDEAVRYVVRHQRPDGTFERSWSRNATNAVFRAVLALTGVAAHGEERRSRARAAERALAHLAATQNGDGGWGHAEAEPSDPISTAYAVIALARGPRARPGGPLDRALAYLVERQHPDGGYRSRPDQAGPRPLLYDVPALADVFVLLALAHATATPDPEGCSR

Drimenyl diphosphate synthase (DMS) (EC 5.4.99.-)

Streptomyces showdoensis

68,268

533

56,702

3D-structure;Isomerase;Magnesium;Metal-binding;Reference proteome;Repeat

GO:0016853; GO:0046872

Evidence at protein level

5

null

PF13243;

IPR032696;IPR008930;

7XQ4;7XQZ;7XR7;7XRA;7XRU;

cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Kitasatosporales (order), Streptomycetaceae (family), Streptomyces (genus)

VO63_21045

false

412

A0A2R2JFI5

METSTQTKAGSLTIVGTGIESIGQMTLQALSYIEAAAKVFYCVIDPATEAFILTKNKNCVDLYQYYDNGKSRLNTYTQMSELMVREVRKGLDVVGVFYGHPGVFVNPSHRALAIAKSEGYRARMLPGVSAEDCLFADLCIDPSNPGCLTYEASDFLIRDRPVSIHSHLVLFQVGCVGIADFNFTGFDNNKFGVLVDRLEQEYGAEHPVVHYIAAMMPHQDPVTDKYTVAQLREPEIAKRVGGVSTFYIPPKARKASNLDIIRRLELLPAGQVPDKKARIYPANQWEPDVPEVEPYRPSDQAAIAQLADHAPPEQYQPLATSKAMSDVMTKLALDPKALADYKADHRAFAQSVPDLTPQERAALELGDSWAIRCAMKNMPSSLLDAARESGEEASQNGFPWVIVVGVIGVIGSVMSTE

Methyltransferase/ribosomally synthesized cyclic peptide omphalotin A precursor ophMA (Omphalotin A biosynthesis cluster protein MA) [Cleaved into: N-methyltranferase ophM (EC 2.1.1.-); Ribosomally synthesized omphalotin core peptide; Follower peptide]

Omphalotus olearius (Jack o'lantern)

72,120

417

45,790

3D-structure;Methylation;Methyltransferase;S-adenosyl-L-methionine;Transferase;Virulence

GO:0008168; GO:0032259

Evidence at protein level

5

null

PF00590;

IPR000878;IPR035996;IPR014777;

5N0N;5N0O;5N0P;5N0Q;5N0R;5N0S;5N0T;5N0U;5N0V;5N0W;5N0X;5N4I;5OUF;6GEW;6QZY;6QZZ;6R00;6TSC;8QAQ;8QAS;8QBP;

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Basidiomycota (phylum), Agaricomycotina (subphylum), Agaricomycetes (class), Agaricomycetidae (subclass), Agaricales (order), Marasmiineae (suborder), Omphalotaceae (family), Omphalotus (genus)

ophMA

false

413

A0A2R4QKX7

MGFSFVTNAAIAAHMPPSKQEIIRRDAKFHPTIWGDHFIQYLDTPIDPPQKVVERMEELKKQVRAMLRDTNLDISLIDWIQRTGIAYHFEEQIAETLKHVYEASTLTTDSSKYLEHFDLRHIALRFRLSRQQGYHASTDVFKRFMDEGDKFKQSIANDIEGMLSLYEASFMSVKGEAILDEALAFTGKNLEATLPNLTGSLAQQVECALEIPLRRCTDLVKARRSISCYENKNGRNEVVLELAKLDFNLLQAVHQRELALLTSWWNELGASTNLPFTRNRVVELYFWVLEVLSKPEHARAREIMVKSIIMASILDDVYDVYGTLEELQLFTSALERWDLQALEQLPNTIKTAYSIVLRVFKEYEDLLKPHEVYRVGFARKALIPYMNAYFLEAKWFYSHHHPSFEEYMDNALVSCGYPFLFLVSLVGLDEIATKDVFEWAIKRPNIVVAASMICRNRDDIVGHKEEQERGDVPSGVECYTKDHGCTEEEACMALQAMVDDAWKDINCELLHDTSMPKAILMRAVGLARIISILYQYRDGYSDSTHETKAHVTQVLVQPIPL

Terpene synthase 3 (PnTPS3) (Copaene synthase) (PnCop) (EC 4.2.3.133) (Germacrene D synthase) (PnGDS) (EC 4.2.3.-)

Piper nigrum (Black pepper)

13,216

561

64,520

Lyase;Magnesium;Metal-binding

GO:0000287; GO:0010333; GO:0010597; GO:0016102; GO:0051762; GO:0052577; GO:0102877; GO:1901931

Evidence at protein level

5

null

PF01397;PF03936;

IPR008949;IPR034741;IPR044814;IPR001906;IPR036965;IPR050148;IPR005630;IPR008930;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), Magnoliidae (clade), Piperales (order), Piperaceae (family), Piper (genus)

TPS3

false

414

A0A2R6W0K6

MAFSAAASASTNLVPAVASGRGGAAASASQHGETARLARFGVSSSACANALSLSSSRSCASMGEVLWANGGAVRLAARRTLRVRAAGAGTIVQPEGFQITSVPTTPIDGQKTGTSGLRKKVKEFQSPNYLANWIQALFDSLPAEDVKGSTLVLGGDGRYFNKEASQIIIKIAAGNGVGKILVGREGIASTPAVSAIIRARKANGGFVMSASHNPGGPKYDWGIKFNYSSGQPAPESITDKIYGNTLSIKEIKQADIPDVNLSELGVHKFGDFSVEVIDPVADYLNLLEEVFDFDLLKGLLTSKDFRFKFDAMHAVTGAYAKPIFVDRLGAPEDSIFNGVPLEDFGGGHPDPNLTYAEELVKIMYGTDAPDFGAASDGDGDRNMILGNHFFITPSDSVAMIAANADAIPYFKTGLKGLARSMPTSGALDRVAKELGLPFFETPTGWKFFGNLMDAGKCSVCGEESFGTGSDHVREKDGIWAVLAWISIVAYKNRDRKVGEKLVTVADIAKEHWAKYGRNFFSRYDYEECESAGANKMVEHLRDIIAKSKKGDKYGNYELELADDFAYTDPIDGSVATKQGIRFIFSDGSRIIFRLSGTGSAGATIRIYVEQYEQDTTKHDLDAQDALKPLIDIALSVSKLQEFTGRTKPTVIT

Phosphoglucomutase 1, chloroplastic (MpPGM1) (EC 5.4.2.2) (Glucose phosphomutase)

Marchantia polymorpha (Common liverwort) (Marchantia aquatica)

3,197

652

69,918

Carbohydrate metabolism;Chloroplast;Glucose metabolism;Isomerase;Magnesium;Metal-binding;Phosphoprotein;Plastid;Reference proteome;Transit peptide

GO:0000287; GO:0004614; GO:0005829; GO:0005975; GO:0005986; GO:0006006; GO:0009409; GO:0009570; GO:0009590; GO:0010319; GO:0019252

Inferred from homology

5

SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000255}.

null

PF24947;PF02878;PF02879;PF02880;

IPR005844;IPR016055;IPR005845;IPR005846;IPR036900;IPR016066;IPR005841;IPR045244;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Marchantiophyta (clade), Marchantiopsida (class), Marchantiidae (subclass), Marchantiales (order), Marchantiaceae (family), Marchantia (genus)

PGM1 Mapoly0202s0014 MARPO_0202s0014

false

415

A0A2R6XIK6

MVVREAMIVPQTVQGGGKGVNGCSLVSNYQNSRDLCLQSAAMEQKSKGVIENCNLGPHDVGVGWKRNSSEGSISSMDSLPCGETVFSPSDPHNSVFRKPRRLGVSESDDESVIDQSQEESLLRKSKRSVMGGTVQPHSAMAQSVDEAAPDHSSTPSDDGKDFPSSRVKFMCSFGGKILPRPSDQQLRYVGGQTRIIGINRDVNFSELRNKMRESFGQCYTFKYQLPDEDLDALVTVSSDEDLENMMEEYDKLEADGSSRLRVFLFPADQDATSFDIDSTGDLRNSEQRYVDAVNGIAESSTRRISDGVLGASPVSSDLLGLELSEPSWGLARGPDAVPMAMLATHHDPNLIHQVPVAHPVSALTGNLSNRSNAPSAPSSAPSSPPLLARNLHGKLPLVGELHQFQYLQDSQFKGVGPQYTGMPSEVAHQDSESYGGSGGSSAASQHEMHYRSTDSRRGPESPPKKFHDALHQDHPITVEQRRLSGTKMPRIGSHGKLTRLSEHSELAPSSRVDSQQMPDIHMAPGELQRLFPQQVPLQQTLWPHAMDTQQDSYRRPDMLQSSGAQPAVSGQQQQGYQPQQQLQHLFRSGLSQTGANHEGAYRQGDQQQQSQQFQEDLHVNPNYIPRSVSSHAIAAGIAAGQSTSYHGSAPSSPRPGFRELPSRHLPGGPQLQHQWTFNGAGYVDQGFGRRVMNYPDQATRSFRLSSSPPRYRDHHPHSEERLHRQAQQVSEPLHHEQVPVSGQLKFETNSVSQAQYDLVPRPQVPQYKGHNPFQEKITSFQDHQEVGDIRRHVLQQGKDNQLLAGQQHLHSILQPQRIDYQESLKQQGDQSIPIHPRFQDGQEKVAEWMVQERALEEEEARKRVLGRIRQAELEEEAAAEAVVSQHKDTHQGVYAGLHLPNDEDLLTSSLGDYPSGNRRNERLESSISNAFPFRHLPPSVLGGYTAPKSRVNPTETSHVAQYVSRPVDTDYLAVAGLRGGGNGQDMRSAALFEVNGLQQTSGYQMPSGPHRLMEERLMPSAFNPITQLQKLRINDNLALNNDMRWSGSEDVRNEPSIPARDRMGGIYEDHHQGLPGLTLGRSAGKLSRPSSNTSIPNLLDETIGEGSLLPSGPSYGTQAQGTNLIDITQSISAIDNPLYSTSYASRLSNTSLGLDSPLVTSGGMLNSSLEGTSFSDYYKIKMGDDLPNAKMPSSKIPSAEDNLSRSSSSSLSELSKSGSEDGLGGQLTMDQRTVDMVVAALDLDRSGSVVQSVLESSDAKEASLSESVHDHSLGKLGSVVGSVGTQSVWPLDSAPTLAAGLWEKKLDEAGMTEETFERHITSDGTTFEELTADDHEVLASTVDKENQEEVRTGLDEPADEDKANSTGLGSDPAAKAIARGLQTIKNADLEELRELGSGTFGTVYHGKWRGTDVAIKRIKASCFAGRPSEQERLIEDFWREACNLGHLHHPNVVAFYGVVADGPGGTLATVTEYMVNGSLKQVLQKKDRTIDRRKRLLIAMDAAFGMEYLHGKNIVHFDLKCENLLVNMRDPHRPICKVGDLGLSKVKHQTMVSGGVRGTLPWMAPELLNGNSSLVTEKVDVFSFGIVMWELLTGEEPYDKMHYGAIIGGIVNNTLRPLIPSWCDPAWRSLMERCWANEPAVRPSFSDIAKELRTMAAALQPKTQAQTQGQSHPHPQMQIV

RAF-like serine/threonine-protein kinase PRAF (EC 2.7.11.1) (Protein PHOTOSYNTHESIS-RELATED RAF) (MpPRAF)

Marchantia polymorpha (Common liverwort) (Marchantia aquatica)

3,197

1,680

184,303

ATP-binding;Auxin signaling pathway;Cytoplasm;Kinase;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase

GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005985; GO:0007165; GO:0009637; GO:0009646; GO:0009733; GO:0009734; GO:0010109; GO:0010114; GO:0010928; GO:0071365

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:38128538}. Note=Broadly distributed to both membrane-associated and intracellular punctate structures. {ECO:0000269|PubMed:38128538}.

null

PF00564;PF07714;

IPR011009;IPR053793;IPR000270;IPR000719;IPR017441;IPR001245;IPR008271;IPR050167;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Marchantiophyta (clade), Marchantiopsida (class), Marchantiidae (subclass), Marchantiales (order), Marchantiaceae (family), Marchantia (genus)

PRAF Mapoly0013s0150 MARPO_0013s0150

false

416

A0A2R8Q1W5

MTECKAEVTPSASNGHRVFSYTLESHTAAAFAIMNELRRERQLCDVTLRVRYCPLDTHVDFVAHKVVLASSSPVFRAMFTNGLKECGMEVVPIEGIHPKVMGRLIEFAYTASISVGEKCVIHVMNGAVMYQIDSVVQACCDFLVEQLDPSNAIGIASFAEQIGCTELHQKAREYIYMNFSQVATQEEFFTLSHCQLVTLISRDELNVRCESEVFHACVAWVQYDREERRPYVQALLQAVRCHSLTPHFLQRQLEHFEWDAQSKDYLSQIFRDLTLHKPTKVIPLRTPKVPQLIYTVGGYFRQSLSFLEAFNPCSGAWLRLADLQVPRSGLAACVISGLLYAVGGRNNGPDGNMDSHTLDCYNPMNNCWRPCAHMSVPRNRIGVGVIDGMIYAVGGSHGCTHHNSVERYDPERDSWQLVSPMLTRRIGVGVAVINRLLYAVGGFDGTHRLSSAECYNPERDEWRSIAAMNTVRSGAGVCALGNYIYVMGGYDGTNQLNTVERYDVEKDSWSFSASMRHRRSALGVTTHHGRIYVLGGYDGNTFLDSVECFDPETDSWTEVTHMKSGRSGVGVAVTMEPCHKELIPCQC

Kelch-like ECH-associated protein 1B

Danio rerio (Zebrafish) (Brachydanio rerio)

7,955

587

65,690

Alternative splicing;Cytoplasm;Kelch repeat;Nucleus;Reference proteome;Repeat;Ubl conjugation pathway

GO:0005634; GO:0005737; GO:0006511; GO:0010506; GO:0016234; GO:0016567; GO:0030536; GO:0031463; GO:0034599; GO:0043161; GO:0071379; GO:0071466; GO:1990756

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z2X8}. Nucleus {ECO:0000250|UniProtKB:Q9Z2X8}. Note=Mainly cytoplasmic. {ECO:0000250|UniProtKB:Q9Z2X8}.

null

PF07707;PF00651;PF01344;PF24681;

IPR011705;IPR017096;IPR000210;IPR047098;IPR030563;IPR015915;IPR006652;IPR011333;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Actinopterygii (superclass), Actinopteri (class), Neopterygii (subclass), Teleostei (infraclass), Osteoglossocephalai (clade), Clupeocephala (no rank), Otomorpha (cohort), Ostariophysi (subcohort), Otophysi (clade), Cypriniphysae (superorder), Cypriniformes (order), Cyprinoidei (suborder), Danionidae (family), Danioninae (subfamily), Danio (genus)

keap1b

false

417

A0A2R8QCI3

MDITVSELMSNFMDSPLVVWVKTFGPLGFSSEDKLSMFMDLVDGVFLHKIMTHIDPSPMNQRVNKQVNNDVNLRIQNLNTVIRHIKNYYQEHLQQLIVMNLPNVLAIAKDPLSGKSMEEMKRMLLLILGCAVQCDRKEEIIEKIKLLDIETQAAIVTHIQEVTHNQENVLDLQWMEVAEIPAEQLDPLSRTMAFHLRKLIDERDESAELVIELTQERDYLQSQQPSGLLGFPSPERTSLSPITLLSKEDRQHLAVELADTKAKLRRSRQELEEKTEQLIDAKNEIERLDSDIQKLKQENTQLLAEARSVRAYRDEVDSLRERAGKVDRLETELSRFKEKLNDVHFYKTRIEELREDNLTLLETKSMLEEQLTGARGRCDKLHELEKENLQLRSKLHDIEIDRDSDKKRLEELLEENMLLEISQKQSMNESAHLGWELEQLAKNNEVNEARKSFVFELNESASSRLLKLEKENQCLQSTIQELREASINMEEGQLHSLELEKENQSLSKKLERLQSQLDQEKQTTQDMENLGEELIKEKQRMEKTLETIQAEKDRQISELEQEKEHLTQAVSSLRKRAQANSEARVREVETENRILHQTISETGGKLARLEAEKRQVTKELESLRERGERCEELEREVPRLERVREQLQREAAALKIGSERAEALERENATLEQDNRRLKKLADTAQNATLRLAVLEKDHQQLEEENLEQRRALETLRPAAARLAQLQQEHAELEREHEEMCRTMEELRSQAKRSERLEKSCGSLSLENQRLQQTLENSSTKMQGLESELRQNEAEMKDLQRELEGLRQKVTWAETLEKENRGMEQELSQLEKEKKQLEKEARRFRQQLEVKEAALEENCLRLASMEKEGTALSKELGRVKEAAGRLKELERENKDLQKQATMDKKTLATLREELVNEKLRVQQQCNELEKLSHELEKIGLNREKLLQEEHSCEDNKYKILETKIESALKKTLELREEKIQSLESRLEESSSLNQQLRTELTTVKKNLEALKQRHEEEAAHSEISQQTLGQTRSLPDKEKWEMEQREATAELLKLKDRLIDVEKNVRQRHVSIDIHRVIFSIVICFCDSLQNAALQTEKYLLKDQLKQIDSQNAQLNAQTLALQKQAASLQEHNTSLHKETAKLQVENSTLSSQSSSLMAQYGALQAQLQTLESEAESLQKQREEASAARDRVTQDHERLLGVHERQASEYEQLIAQHAALKASQRALEQENRTLENKYMVLLKQKDAMEALEESLQRDRESLGEEIRKNTLILGENRSLREEVDRVSHMHTQLRQEYDSLQLQTKELKTSLNESQLELNRWQARYDQLKEQHQGLDISMTKLDNHCELLTRLKGNLEEENHHLLSQIQMLSQQNQTLLERTMESKELYHEEQKQYIDKLNSLRRQKEKLEEKIMDQYKFYDPTPKKSRQWVGAKAIAKFIKPKKESSRERPDAPRERIRSAPDIPLPEIPTCIDCPESAPPPPPPPLPPRQSRPSLDSMNSQSVEENHVQSPTLSSPALNGRVLNESGGSRSRDGYRSIGGGSESMNGYEELLRWRSREPGGATCSTPLSRNSHNAPGFTSSSSLRPGRRPKGLVSEEDLRHHSPDAGFGSGVHGNTGHRPSSAEFSRNTSSSNSPVSSKGSLDCLQGRSASLSSDDVVGLAHEGSRLSQSSLLPRSSTLPCDSPSASRPSQRPASRRPSSPGSEMVTLEEFLQESNALSPPTVQTGSREDLMTDYFTRSTRPVPLRDGAKTPTNYVTPTVKTTPPELDARTPKPGHSVKPSVRLTDTSTPPSHSQTLPNRGAGLRPSALQQSSPRGSVGGSASLSRTFSLASADLLRSNGPDSYRTEAASPNQNDVVMRRPGAVARERPMSARVTGSSPLPGDPGHISVDPRRLSLAQPRDEFSLVSPPPLHSSSMSLQAEREYVGSGSSRAGAARSGSAQPRGAPHRGEVAMVTPVRAVPALRLNDLEEEPQEQREAESPLLKKADTTNLSYASKEQPTSKPASPDPNNDPQTVWYEYGCV

Protein Daple (Coiled-coil domain-containing protein 88C)

Danio rerio (Zebrafish) (Brachydanio rerio)

7,955

2,023

230,337

Alternative splicing;Cell junction;Coiled coil;Cytoplasm;Guanine-nucleotide releasing factor;Reference proteome;Wnt signaling pathway

GO:0001841; GO:0001965; GO:0003383; GO:0005085; GO:0005737; GO:0005813; GO:0007264; GO:0008017; GO:0016055; GO:0030054; GO:0030705; GO:0031122; GO:0051959; GO:0070161

Evidence at transcript level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9P219}. Cell junction {ECO:0000250|UniProtKB:Q9P219}. Note=Enriched at apical cell junctions. {ECO:0000250|UniProtKB:Q9P219}.

null

PF19047;

IPR001715;IPR036872;IPR043936;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Actinopterygii (superclass), Actinopteri (class), Neopterygii (subclass), Teleostei (infraclass), Osteoglossocephalai (clade), Clupeocephala (no rank), Otomorpha (cohort), Ostariophysi (subcohort), Otophysi (clade), Cypriniphysae (superorder), Cypriniformes (order), Cyprinoidei (suborder), Danionidae (family), Danioninae (subfamily), Danio (genus)

ccdc88c

false

418

A0A2R8QF68

MQRIAGITKMVTHRRWLGLLLLLLCVGYSHGMPHVLRFGGIFESIESGPSGAEELAFKFALNTINRNRTLLPNTTLTYDIQRINIHDSFEASRKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTKWKHQVSDNRDSFYVNLYPDFSSLSRAILDLVHFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNIRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCGHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENSQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVAVAVQQSPQITVSSLQCNRHKPWRFGNRFMTLIKEAHWDGLTGRINFNRTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTENQKGKTANVTDSLSNRSLVVSTILEEPYVMFKKSDKPLYGNDRFEGYCVDLLRELAAILGFGYELRLVEDGRYGAQDESSGQWNGMVRELMDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGVVEDGSTMTFFKKTKISTYDKMWEFMSSRRHSVMVKSIEEGIERVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKAYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEENKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKQNAQLEKRSFCSAMVDELRVSLKCQRRLKHKPQPPVMVKTDEVINMHTFNDRRLPGKETMA

Glutamate receptor ionotropic, kainate 2 (GluK2)

Danio rerio (Zebrafish) (Brachydanio rerio)

7,955

908

102,520

Cell membrane;Disulfide bond;Glycoprotein;Ion channel;Ion transport;Ligand-gated ion channel;Membrane;Postsynaptic cell membrane;Receptor;Reference proteome;Signal;Synapse;Transmembrane;Transmembrane helix;Transport

GO:0005886; GO:0015277; GO:0022849; GO:0032983; GO:0035249; GO:0042734; GO:0050804; GO:0098839; GO:1904315

Inferred from homology

5

SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P42260}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P42260}; Multi-pass membrane protein {ECO:0000255}.

SIGNAL 1..31; /evidence="ECO:0000255"

TRANSMEM 562..582; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 639..659; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 820..840; /note="Helical"; /evidence="ECO:0000255"

PF01094;PF00060;PF10613;

IPR001828;IPR019594;IPR001508;IPR015683;IPR001320;IPR028082;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Actinopterygii (superclass), Actinopteri (class), Neopterygii (subclass), Teleostei (infraclass), Osteoglossocephalai (clade), Clupeocephala (no rank), Otomorpha (cohort), Ostariophysi (subcohort), Otophysi (clade), Cypriniphysae (superorder), Cypriniformes (order), Cyprinoidei (suborder), Danionidae (family), Danioninae (subfamily), Danio (genus)

grik2

false

419

A0A2R8VHR8

MLKMSGWQRQSQNNSRNLRRECSRRKCIFIHHHT

DDIT3 upstream open reading frame protein (Alternative DDIT3 proteins) (AltDDIT3)

Mus musculus (Mouse)

10,090

34

4,240

Alternative initiation;Cytoplasm;Nucleus;Reference proteome

GO:0002086; GO:0003677; GO:0003700; GO:0005634; GO:0005770; GO:0006355; GO:0006357; GO:0006983; GO:0007605; GO:0009611; GO:0010467; GO:0030968; GO:0036119; GO:0045454; GO:0045599; GO:0060840; GO:0061771; GO:0070059; GO:0070509; GO:1904738; GO:1990874

Evidence at transcript level

5

SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H6Z9}. Cytoplasm {ECO:0000250|UniProtKB:Q9H6Z9}. Note=Colocalizes with WDR83 in the cytoplasm. {ECO:0000250|UniProtKB:Q62630}.

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Mammalia (class), Theria (clade), Eutheria (clade), Boreoeutheria (clade), Euarchontoglires (superorder), Glires (clade), Rodentia (order), Myomorpha (suborder), Muroidea (clade), Muridae (family), Murinae (subfamily), Mus (genus), Mus (subgenus)

Ddit3

false

420

A0A2R9YJI3

MESMPSSLTHQRFGLLNKHLTRTGNTREGRMHTPPVLGFQAIMSNVTVLDNIEPLDFEMDLKTPYPVSFQVSLTGFLMLEIVLGLSSNLTVLALYCMKSNLVSSVSNIVTMNLHVLDVLVCVGCIPLTIVVVLLPLEGNNALICCFHEACVSFASVATAANVLAITLDRYDISVRPANRVLTMGRAVALLGSIWALSFFSFLVPFIEEGFFSQAGNERNQTEAEEPSNEYYTELGLYYHLLAQIPIFFFTAVVMLVTYYKILQALNIRIGTRFHSVPKKKPRKKKTISMTSTQPESTDASQSSAGRNAPLGMRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPITVLNTVILSVGPSNFTVRLRLGFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMKKRVVSVVEADPMPNNVVIHNSWIDPKRNKKVTFEETEVRQKCLSSEDVE

G-protein coupled receptor 22

Danio rerio (Zebrafish) (Brachydanio rerio)

7,955

460

51,763

Cell membrane;Cilium biogenesis/degradation;G-protein coupled receptor;Membrane;Receptor;Reference proteome;Transducer;Transmembrane;Transmembrane helix

GO:0001947; GO:0003140; GO:0004930; GO:0005886; GO:0007186; GO:0007368; GO:0030030; GO:0032870; GO:0061371; GO:0070121; GO:0071907; GO:0071910

Evidence at transcript level

5

SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:D4A3U0}; Multi-pass membrane protein {ECO:0000255}.

null

TRANSMEM 75..95; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 378..398; /note="Helical; Name=7"; /evidence="ECO:0000255"

PF00001;

IPR000276;IPR017452;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Actinopterygii (superclass), Actinopteri (class), Neopterygii (subclass), Teleostei (infraclass), Osteoglossocephalai (clade), Clupeocephala (no rank), Otomorpha (cohort), Ostariophysi (subcohort), Otophysi (clade), Cypriniphysae (superorder), Cypriniformes (order), Cyprinoidei (suborder), Danionidae (family), Danioninae (subfamily), Danio (genus)

gpr22a

false

421

A0A2S1XB67

MIKKVPIVLSIFCFLLLLSSSHGSIPEAFLNCISNKFSLDVSILNILHVPSNSSYDSVLKSTIQNPRFLKSPKPLAIITPVLHSHVQSAVICTKQAGLQIRIRSGGADYEGLSYRSEVPFILLDLQNLRSISVDIEDNSAWVESGATIGEFYHEIAQNSPVHAFPAGVSSSVGIGGHLSSGGFGTLLRKYGLAADNIIDAKIVDARGRILDRESMGEDLFWAIRGGGGASFGVIVSWKVKLVKVPPMVTVFILSKTYEEGGLDLLHKWQYIEHKLPEDLFLAVSIMDDSSSGNKTLMAGFMSLFLGKTEDLLKVMAENFPQLGLKKEDCLEMNWIDAAMYFSGHPIGESRSVLKNRESHLPKTCVSIKSDFIQEPQSMDALEKLWKFCREEENSPIILMLPLGGMMSKISESEIPFPYRKDVIYSMIYEIVWNCEDDESSEEYIDGLGRLEELMTPYVKQPRGSWFSTRNLYTGKNKGPGTTYSKAKEWGFRYFNNNFKKLALIKGQVDPENFFYYEQSIPPLHLQVEL

O-acetylstemmadenine oxidase (CrASO) (EC 1.21.3.11) (Precondylocarpine acetate synthase)

Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)

4,058

529

59,214

Alkaloid metabolism;Disulfide bond;Endoplasmic reticulum;FAD;Flavoprotein;Glycoprotein;Oxidoreductase;Signal;Vacuole

GO:0005773; GO:0005783; GO:0009820; GO:0016491; GO:0031982; GO:0071949

Evidence at protein level

5

SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:29724909}. Vacuole {ECO:0000269|PubMed:29724909}. Vesicle {ECO:0000269|PubMed:29724909}. Note=First targeted to endoplasmic reticulum (ER) and progressively secreted to vacuole by ER-derived vesicles. {ECO:0000269|PubMed:29724909}.

SIGNAL 1..23; /evidence="ECO:0000255"

null

PF08031;PF01565;

IPR012951;IPR016166;IPR036318;IPR016167;IPR016169;IPR006094;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), lamiids (clade), Gentianales (order), Apocynaceae (family), Rauvolfioideae (subfamily), Vinceae (tribe), Catharanthinae (subtribe), Catharanthus (genus)

ASO PAS

false

422

A0A2S4N3N0

MKKTAIAIAVALAGFATVAQAAPKDNTWYTGAKLGWSQYHDTGFIPNNGPTHENQLGAGAFGGYQVNPYVGFEMGYDWLGRMPYKGDNINGAYKAQGVQLTAKLGYPITDDLDIYTRLGGMVWRADTKANVPGGASFKDHDTGVSPVFAGGVEYAITPEIATRLEYQWTNNIGDANTIGTRPDNGLLSLGVSYRFGQGEAAPVVAPAPAPEVQTKHFTLKSDVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQSVVDYLISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEVKGIKDVVTQPQA

Outer membrane protein A (Outer membrane porin A)

Shigella flexneri

623

348

37,283

3D-structure;Cell outer membrane;Conjugation;Direct protein sequencing;Disulfide bond;Host-virus interaction;Ion transport;Membrane;Porin;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane beta strand;Transport

GO:0009279; GO:0015288; GO:0034220; GO:0046930

Evidence at protein level

5

SUBCELLULAR LOCATION: Extracellular vesicle. Note=(Microbial infection) Upon infection with phage Sf6 is found in extracellular vesicles that associate with the tails of mature phage particles. {ECO:0000269|PubMed:22386055}.; SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250|UniProtKB:P0A910, ECO:0000255|HAMAP-Rule:MF_00842}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00842, ECO:0000305|PubMed:21071053}.

SIGNAL 1..21; /evidence="ECO:0000255|HAMAP-Rule:MF_00842, ECO:0000269|PubMed:21071053"

TRANSMEM 27..37; /note="Beta stranded"; /evidence="ECO:0000255|HAMAP-Rule:MF_00842"; TRANSMEM 55..66; /note="Beta stranded"; /evidence="ECO:0000255|HAMAP-Rule:MF_00842"; TRANSMEM 70..78; /note="Beta stranded"; /evidence="ECO:0000255|HAMAP-Rule:MF_00842"; TRANSMEM 96..107; /note="Beta stranded"; /evidence="ECO:0000255|HAMAP-Rule:MF_00842"; TRANSMEM 112..120; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:P0A910, ECO:0000255|HAMAP-Rule:MF_00842"; TRANSMEM 146..155; /note="Beta stranded"; /evidence="ECO:0000255|HAMAP-Rule:MF_00842"; TRANSMEM 160..167; /note="Beta stranded"; /evidence="ECO:0000255|HAMAP-Rule:MF_00842"; TRANSMEM 186..194; /note="Beta stranded"; /evidence="ECO:0000255|HAMAP-Rule:MF_00842"

PF00691;PF01389;

IPR050330;IPR011250;IPR006664;IPR002368;IPR006665;IPR006690;IPR036737;IPR000498;

3NB3;

cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Gammaproteobacteria (class), Enterobacterales (order), Enterobacteriaceae (family), Shigella (genus)

ompA SF0957

false

423

A0A2T4VDM4

MGLCSDPAITYLKRLGYNVVRLPREGIQPLHLLGQQRGTVEYLGSLEKLITQPPSEPPAITRDQAAAGINGQKTENLSFSIGINILKSVLAQFGAGAGIEAQYNQARKVRFEFSNVLADSVEPLAVGQFLKMAEVDADNPVLKQYVLGNGRLYVITQVIKSNEFTVAAEKSGGGSIQLDVPEIQKVVGGKLKVEASVSSQSTVTYKGEKQLVFGFKCFEIGVKNGEITLFASQPGAIAMALDAAGGVMPSDSALLDEGGLLDLEGF

Gasdermin bGSDM (bGSDM) (Bacterial gasdermin) [Cleaved into: Gasdermin bGSDM, N-terminus]

Vitiosangium sp. (strain GDMCC 1.1324)

2,138,576

266

28,275

3D-structure;Antiviral defense;Cell inner membrane;Cell membrane;Cytoplasm;Lipoprotein;Membrane;Palmitate;Reference proteome;Transmembrane;Transmembrane beta strand

GO:0005737; GO:0005886; GO:0051607

Evidence at protein level

5

SUBCELLULAR LOCATION: [Gasdermin bGSDM]: Cytoplasm {ECO:0000305|PubMed:35025633}.; SUBCELLULAR LOCATION: [Gasdermin bGSDM, N-terminus]: Cell inner membrane {ECO:0000305|PubMed:38509367}; Multi-pass membrane protein {ECO:0000305|PubMed:38509367}.

null

TRANSMEM 69..85; /note="Beta stranded"; /evidence="ECO:0000305|PubMed:38509367, ECO:0007744|PDB:8SL0"; TRANSMEM 97..114; /note="Beta stranded"; /evidence="ECO:0000305|PubMed:38509367, ECO:0007744|PDB:8SL0"; TRANSMEM 163..180; /note="Beta stranded"; /evidence="ECO:0000305|PubMed:38509367, ECO:0007744|PDB:8SL0"; TRANSMEM 189..205; /note="Beta stranded"; /evidence="ECO:0000305|PubMed:38509367, ECO:0007744|PDB:8SL0"

null

7N51;8SL0;

cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Myxococcota (phylum), Myxococcia (class), Myxococcales (order), Cystobacterineae (suborder), Archangiaceae (family), Vitiosangium (genus), unclassified Vitiosangium (no rank)

DAT35_31115 Ga0334635_1658

false

424

A0A2T5Y4G4

MKKRIFIGSSSEQLTILNEIVDLLGDDVECIPWTDAFALNKSGLDSLIKQTRLADYSILIATKDDLTKQRGESLTKPRDNVVFEFGLFLGAAGPEKCYLIAEEDTDLPTDLDGITVAKFTRNSGQYNSLDKIVESIRTHLVKIAEMSQLGLLPSTALAIGYYNSFIKRVCEEIHGSECVELEGKKIKVKSFRVDVVIPETLDDNGVGNFTTLYNKRYGLSKATTCTNPALLGTRGFPFHFKVDPPDANQESPVDIHLLDIPSTLSTIVESLKLYLPSNQVGQDFDMDYLEMRELENFAKVLKYLIGRNAATKGYVNVLTNVKL

CD-NTase-associated protein 12 (Cap12) (NAD(+) hydrolase) (EC 3.2.2.5) (TIR-STING) (SfSTING)

Sphingobacterium faecium (strain DSM 11690 / JCM 21820 / NBRC 15299 / NCIMB 13408 / KS 0470)

1,220,575

323

35,943

3D-structure;Antiviral defense;Hydrolase;Nucleotide-binding

GO:0000166; GO:0003953; GO:0050135; GO:0051607

Evidence at protein level

5

null

PF10137;PF20300;

IPR019302;IPR046876;

7UN8;7UN9;7UNA;

cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), FCB group (clade), Bacteroidota/Chlorobiota group (clade), Bacteroidota (phylum), Sphingobacteriia (class), Sphingobacteriales (order), Sphingobacteriaceae (family), Sphingobacterium (genus), Sphingobacterium faecium (species)

cap12 C8N37_104320 SF1_08920

false

425

A0A2U1LIM9

MQSTTSVKLSPFDLMTALLNGKVSFDTSNTSDTNIPLAVFMENRELLMILTTSVAVLIGCVVVLVWRRSSSAAKKAAESPVIVVPKKVTEDEVDDGRKKVTVFFGTQTGTAEGFAKALVEEAKARYEKAVFKVIDLDDYAAEDDEYEEKLKKESLAFFFLATYGDGEPTDNAARFYKWFTEGEEKGEWLEKLQYAVFGLGNRQYEHFNKIAKVVDEKLVEQGAKRLVPVGMGDDDQCIEDDFTAWKELVWPELDQLLRDEDDTSVATPYTAAVAEYRVVFHDKPETYDQDQLTNGHAVHDAQHPCRSNVAVKKELHSPLSDRSCTHLEFDISNTGLSYETGDHVGVYVENLSEVVDEAEKLIGLPPHTYFSVHTDNEDGTPLGGASLPPPFPPCTLRKALASYADVLSSPKKSALLALAAHATDSTEADRLKFLASPAGKDEYAQWIVASHRSLLEVMEAFPSAKPPLGVFFASVAPRLQPRYYSISSSPKFAPNRIHVTCALVYEQTPSGRVHKGVCSTWMKNAVPMTESQDCSWAPIYVRTSNFRLPSDPKVPVIMIGPGTGLAPFRGFLQERLAQKEAGTELGTAILFFGCRNRKVDFIYEDELNNFVETGALSELVTAFSREGATKEYVQHKMTQKASDIWNLLSEGAYLYVCGDAKGMAKDVHRTLHTIVQEQGSLDSSKAELYVKNLQMAGRYLRDVW

NADPH--cytochrome P450 reductase 1 (CPR 1) (P450R 1) (EC 1.6.2.4)

Artemisia annua (Sweet wormwood)

35,608

704

78,182

Endoplasmic reticulum;FAD;Flavoprotein;FMN;Glycoprotein;Membrane;NADP;Oxidoreductase;Reference proteome;Transmembrane;Transmembrane helix

GO:0003958; GO:0005789; GO:0005829; GO:0010181; GO:0016491; GO:0050660; GO:0050661; GO:0051762

Evidence at protein level

5

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03212}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03212}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03212}.

null

TRANSMEM 46..66; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03212"

PF00667;PF00258;PF00175;

IPR003097;IPR017927;IPR001094;IPR008254;IPR001709;IPR029039;IPR039261;IPR023173;IPR001433;IPR023208;IPR017938;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), campanulids (clade), Asterales (order), Asteraceae (family), Asteroideae (subfamily), Anthemideae (tribe), Artemisiinae (subtribe), Artemisia (genus)

CPR1 CPR CTI12_AA484860

false

426

A0A2U9GGW3

MAPLGVSGLVGKLSTELEVDCDAEKYYNMYKHGEDVKKAVPHLCVDVKIISGDPTSSGCIKEWNVNIDGKTIRSVEETTHDDETKTLRHRVFEGDVMKDFKKFDTIMVVNPKPDGNGCVVTRSIEYEKTNENSPTPFDYLQFGHQAIEDMNKYLRDSESN

Thebaine synthase 2 (EC 4.2.99.24)

Papaver somniferum (Opium poppy)

3,469

160

18,066

3D-structure;Alkaloid metabolism;Lyase

GO:0006952; GO:0009820; GO:0016835; GO:0042803

Evidence at protein level

5

null

PF00407;

IPR000916;IPR052006;IPR023393;

6KA2;6KA3;

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), Ranunculales (order), Papaveraceae (family), Papaveroideae (subfamily), Papaver (genus)

THS2

false

427

A0A2Y9GHM3

MKVLWAALVVALLAGCWADVEPESPLQGKPEPELEPELEPKRELEQEVEAEAGWQAGQPWELALARFWDYLRWVQTLSDQVQEDMLSNQVTQELTTLMEETMKEIKAYRAELEEQLGPMASETQARVAKELQAAQARLRSDMEDVRTRLTQYRGEVQAMLGQSTEELRARFASHMRKLRKRVLRDAEDLQKRLAVYRAGVREGAERSVSSIRERLWPLLEQARTRHANLATQPLRERVDALGQQLRGRLEEVGSRARSHLDEVREQMEEVQAKMEEQANQMRQQVEAFQARLKSWFEPLVEDMQRQWAGLVEKVQVAVGTSPTTPPLETK

Apolipoprotein E (Apo-E)

Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi)

29,088

330

38,091

Chylomicron;Endosome;Extracellular matrix;Glycoprotein;HDL;Heparin-binding;Lipid-binding;Oxidation;Phosphoprotein;Reference proteome;Repeat;Secreted;Signal;VLDL

GO:0005543; GO:0008201; GO:0008203; GO:0032438; GO:0033344; GO:0033700; GO:0034361; GO:0034362; GO:0034364; GO:0042157; GO:0042627; GO:0055090; GO:0060228; GO:0070062; GO:0097487; GO:0120020

Inferred from homology

5

SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02649}. Secreted, extracellular space {ECO:0000250|UniProtKB:P02649}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P02649}. Extracellular vesicle {ECO:0000250|UniProtKB:P02649}. Endosome, multivesicular body {ECO:0000250|UniProtKB:P02649}. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans-dependent manner. Lipidation induces the release from the extracellular matrix. Colocalizes with CD63 and PMEL at exosomes and in intraluminal vesicles within multivesicular endosomes. {ECO:0000250|UniProtKB:P02649}.

SIGNAL 1..18; /evidence="ECO:0000255"

null

PF01442;

IPR000074;IPR050163;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Mammalia (class), Theria (clade), Eutheria (clade), Boreoeutheria (clade), Laurasiatheria (superorder), Carnivora (order), Caniformia (suborder), Pinnipedia (clade), Phocidae (family), Monachinae (subfamily), Monachini (tribe), Neomonachus (genus)

APOE

false

428

A0A2Z5D854

MDPAAIFLILAIPIASVYLLFYHKKRVNGLSSPPGPRGLPFIGHFYQIYKSECAHEYISNLSKQYGSLMTLHLGSVPALVVSSPKMAQEVLKTQDLVFCSRAQMTGSGKLSYNGLEMAFAPYGEHWRNVRKMCTLELFTQKRAQFNFRPVREDEVSRMVGRLSEAAAASEDVNAYECFTNFATSIISRVAFGKRYDEDNLGKEKFQRMVADIEAMFAAFFVSDFFPMFGWIDRLSGVKAVLDRNFNEMDTFYQELIDEHLKPDRPESLNGDLIDVMLKNKGSFLTMDSIKAILLNVFSGGIGTTGSALVFAMTALLRNQRVMKKAQEEVRSVIGKKEIVDEDDIQKLPYLRAVVKETLRLYPPGPLLIPRVAMESCVLGEDEDHMYMIKPNTIVYVNTWGIGRDPKYWKNPLEFMPERFFERPDLNYTGQQFEYLPFGSGRRICAGIIIGQNNVEVGLANLLYSFDWEPPTGKTFEDIDDQPCNGLTLAKKNPLYIRPKIYVHP

Xanthotoxol synthase (EC 1.14.14.-) (Cytochrome P450 CYP71AZ4) (Fraxetin synthase) (EC 1.14.14.-)

Pastinaca sativa (Wild parsnip) (Anethum pastinaca)

4,041

504

57,254

Endoplasmic reticulum;Heme;Iron;Membrane;Metal-binding;Microsome;Monooxygenase;Oxidoreductase;Transmembrane;Transmembrane helix

GO:0004497; GO:0005506; GO:0005783; GO:0009611; GO:0009805; GO:0016020; GO:0016705; GO:0020037

Evidence at protein level

5

SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:Q6QNI4}; Single-pass membrane protein {ECO:0000255}.

null

TRANSMEM 3..23; /note="Helical"; /evidence="ECO:0000255"

PF00067;

IPR001128;IPR017972;IPR002401;IPR036396;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), campanulids (clade), Apiales (order), Apiineae (suborder), Apiaceae (family), Apioideae (subfamily), apioid superclade (clade), Tordylieae (tribe), Tordyliinae (subtribe), Pastinaca (genus)

CYP71AZ4

false

429

A0A2Z5GDY5

MENTLSALRSLMASHSPPLDALVVPSEDYHQSEYVSARDKRREFVSGFSGSAGLALITKDVALLWTDGRYFLQAEQQLSDEWKLMRIGEDPAVDTWMADNLLKEASIGVDPWCISIDTAQRWERSFAEKQQKLVQTTKNLVDEVWADRPPAEINAVVVQPLKFAGRSVADKLKDLRKKLVQEQARGIIFTSLDEVAWLYNIRGNDVAYCPVVHAFAIVTSNSAFLYVDKRKVSAEVKSHLEENGIEIREYTAVSFDVALLATDELDTTSTAKDTLAEITKQAEKFVSETNKSVNGKHQAKENSNNLIWADPGSCCYAVYSKLNPDTVLLQQSPLALAKALKNPVELEGLKQAHIRDGAAVVQYLVWLDKQMQDIFGASGYFSEGNTVKKEELSQSLKLTEVTVSDKLEGFRASKKHFRGLSFPTISSVGPNGAVIHYSPKAETCAELDPDKIYLFDSGAQYLDGTTDITRTVHFGKPSAHEKACYTAVLKGHIALGNAVFPNGTNGHALDILARIPLWKNGLDYRHGTGHGIGSYLNVHEGPHLISFKPRNVPLQSSMTVTDEPGYYEDGAFGIRLENVLIINEADTKFNFGDKGYLSFEHITWAPYQTKLIDLNLLTPDEINWLNSYHSRCRDILQPHLDDAAENEWLKKATEPVGV

Aminopeptidase P1 (LjAPP1) (EC 3.4.11.9)

Lotus japonicus (Lotus corniculatus var. japonicus)

34,305

658

73,207

Aminopeptidase;Cell membrane;Cytoplasm;Endoplasmic reticulum;Hydrolase;Manganese;Membrane;Metal-binding;Metalloprotease;Microsome;Nodulation;Nucleus;Protease;Zinc

GO:0005634; GO:0005737; GO:0005783; GO:0006508; GO:0009609; GO:0009877; GO:0019897; GO:0046872; GO:0070006

Evidence at protein level

5

SUBCELLULAR LOCATION: Nucleus {ECO:0000269|Ref.1}. Cytoplasm {ECO:0000269|Ref.1}. Cell membrane {ECO:0000269|Ref.1}; Peripheral membrane protein {ECO:0000269|Ref.1}. Microsome membrane {ECO:0000250|UniProtKB:F4JQH3}; Peripheral membrane protein {ECO:0000250|UniProtKB:F4JQH3}.

null

PF01321;PF16189;PF00557;PF16188;

IPR029149;IPR036005;IPR000587;IPR000994;IPR033740;IPR032416;IPR001131;IPR050422;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), rosids (clade), fabids (clade), Fabales (order), Fabaceae (family), Papilionoideae (subfamily), 50 kb inversion clade (clade), NPAAA clade (clade), Hologalegina (clade), robinioid clade (clade), Loteae (tribe), Lotus (genus)

APP1

false

430

A0A2Z5QKZ7

MALVNHRENVKGRAQILAIGTANPKNCFRQVDYPDYYFRVTKSDHLIDLKAKFKRMCEKSMIEKRYMHVNEEILEQNPSMNHGGEKMVSSLDVRLDMEIMEIPKLAAEAATKAMDEWGQPKSRITHLVFHSTLGTVMPGVDYELIKLLGLNPSVKRFMLYHLGCYGGGTVLRLAKDLAENNPGSRVLVLCCEMMPSGFHGPPSLQHAHLDILTGHAIFGDGAGAVIVGCVDPSGGTNGVVERGVRRYEQPLFEIHSAYQTVLPDSKDAVGGRLREAGLIYYLSKRLSNDVSGKIDECCLAEAFSAAIKDNFEDWNSLFWIVHPAGRPILDKLDAKLGLNKEKLRASRNVLRDYGNMWSSSVLFVLDEMRKGSIAQRKTTTGEGFEWGVLLGFGPGVTVETVVLRSVPTAKLK

Orcinol synthase (RdORS) (EC 2.3.1.-)

Rhododendron dauricum (Azalea daurica)

880,079

412

45,708

Acyltransferase;Transferase

GO:0016114; GO:0016747; GO:0030639; GO:0042802; GO:0042803; GO:0046197

Evidence at protein level

5

null

PF02797;PF00195;

IPR012328;IPR001099;IPR018088;IPR011141;IPR016039;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), Ericales (order), Ericaceae (family), Ericoideae (subfamily), Rhodoreae (tribe), Rhododendron (genus)

ORS

false

431

A0A2Z5XAU0

MSEPTSSSSLDITSNCIIETPLQPSDFLPKSANLFPKFPERISVDSWELWEFDTFDTNGSVAFGCSLYRDARGVEQGGFHAEVNALWPDGTHWGETLYFAVSEVVENSDGTTGGKWLSKDGGSITFHIASDYTAAALDFNVPGKVSGTMELRNHANVSPTSNLPASDAEAQLCPGVYYTFPMGPVATSVTATFSSVGANGESRELFISSGYGGMVRGWSARPWPTFMNDAYYVVAQVGPYMLQILRTLGSVFVQHKPFAVARLYLDGSLVSAANTVVGDELTAHADDVKGDAVRLTKVQPDEKSQGLSGKFRDGNVGYVLEFAKKDSEHGWTFQISHKRAVWSEPTSAPGPDGTGKSGWIEAISGGAKGENYEGHGFGGQLQIPVP

Diels-Alderase phm7 (EC 5.5.1.-) (Phomasetin biosynthesis cluster protein 7)

Pyrenochaetopsis sp

1,756,125

386

41,434

3D-structure;Isomerase

GO:0016853

Evidence at protein level

5

null

PF22903;PF24137;

IPR054499;

7DMO;7E5U;7E5V;

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Ascomycota (phylum), saccharomyceta (clade), Pezizomycotina (subphylum), leotiomyceta (clade), dothideomyceta (clade), Dothideomycetes (class), Pleosporomycetidae (subclass), Pleosporales (order), Pleosporineae (suborder), Pyrenochaetopsidaceae (family), Pyrenochaetopsis (genus), unclassified Pyrenochaetopsis (no rank)

phm7

false

432

A0A336U966

MGFYRNLVLVAASCTQALGLCPAPRCDSPDIRHEWGELSREDRLSYISAVQCMKDRPPELSVEEVPAVRSRYDDFTAVHINYTLQIHNSGIFLPWHRHFIWLWEKALREECGFTGTLPYWDWVMWPNLAASPLFDGTETSLSGDGEFNATEQPTELNPEPGLTITIPRGAGGGCVRTGPFKDWVINMGPFAFNESYEPALPDHAFDYNPRCLVRSLNDWVIQTYNNQTVVDTLLDSPDIVEFQNIMGGFPNPPIPIGPHAMGHRSLGPDMLDFFASPQDPAFWQHHGMVDRLWTVWQDADEPWRRFALNGSSTTWYKDDTPEVTLQTTVEFGILDEPRPLYELMSPTAGPYCYTYT

Tyrosinase P (EC 1.14.18.-)

Aspergillus terreus

33,178

356

40,470

Copper;Endoplasmic reticulum;Glycoprotein;Golgi apparatus;Metal-binding;Oxidoreductase;Signal

GO:0005788; GO:0005796; GO:0016491; GO:0046872

Evidence at protein level

5

SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:27133313, ECO:0000269|PubMed:29270299}. Golgi apparatus lumen {ECO:0000269|PubMed:27133313, ECO:0000269|PubMed:29270299}. Note=The oxidizing environment of Golgi or endoplasmic reticulum (ER) is required for tyrP to be active. {ECO:0000269|PubMed:29270299}.

SIGNAL 1..19; /evidence="ECO:0000255"

null

PF00264;

IPR008922;IPR050316;IPR002227;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Ascomycota (phylum), saccharomyceta (clade), Pezizomycotina (subphylum), leotiomyceta (clade), Eurotiomycetes (class), Eurotiomycetidae (subclass), Eurotiales (order), Aspergillaceae (family), Aspergillus (genus), Aspergillus subgen. Circumdati (subgenus)

tyrP

false

433

A0A343URW6

MEFVVSLFAFVVSCFILLKVAKNSKNPKRNTNLELPPGPKQLPIIGNLHQLGGGLAHHVLRNLGKQYGPLMHLKIGELSTIVVSSTEIAKEVFKTHDIHFSNRPSHILVFKIVSYDYKDIVLSQYGKYWRELRKVCNLELLSPNRVQSFRSIREDAVLNMMKSISSNDGKVVNLSEMILSLIYGITARAAFGVWSKKHEEFIRLESEIQRLATTFVLADMFPSIKFLGALSGLRYKVEKVHKKVDDILEGILKEHRRQNNNMTEENGKKDLVDVLLNIQKNGDMETPFTDQHIKAIIFDMFSAGTLTSTIAVDWAMAEMMKNPSVLKRAQDEVRNVYNGIGNVDESKLDELKYLQAVIKETLRIHPGTPIVHRETREECEINGYRIPAKARVMVNAWAISRDPNYWPEPDIFKPERFLGSEVDFKGTHFEYIPFGAGRRICPGISYAIANVQLPLAQLLYHFEWKLPGGMKPEELDMTEILGTAAQRKENLLLIPNSHSCSSLKQV

Tabersonine 6,7-epoxidase isoform 1 (EC 1.14.14.-) (Cytochrome P450 71D521)

Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)

4,058

506

57,513

Alkaloid metabolism;Endoplasmic reticulum;Glycoprotein;Heme;Iron;Membrane;Metal-binding;Monooxygenase;Oxidoreductase;Transmembrane;Transmembrane helix

GO:0004497; GO:0005506; GO:0005789; GO:0016705; GO:0020037; GO:0035835

Evidence at protein level

5

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29934299}; Single-pass membrane protein {ECO:0000255}.

null

TRANSMEM 1..21; /note="Helical"; /evidence="ECO:0000255"

PF00067;

IPR001128;IPR017972;IPR002401;IPR036396;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), lamiids (clade), Gentianales (order), Apocynaceae (family), Rauvolfioideae (subfamily), Vinceae (tribe), Catharanthinae (subtribe), Catharanthus (genus)

TEX1 CYP71D521

false

434

A0A348FUE1

MSPMDLQESAAALVRQLGERVEDRRGFGFMSPAIYDTAWVSMISKTIDDQKTWLFAECFQYILSHQLEDGGWAMYASEIDAILNTSASLLSLKRHLSNPYQITSITQEDLSARINRAQNALQKLLNEWNVDSTLHVGFEILVPALLRYLEDEGIAFAFSGRERLLEIEKQKLSKFKAQYLYLPIKVTALHSLEAFIGAIEFDKVSHHKVSGAFMASPSSTAAYMMHATQWDDECEDYLRHVIAHASGKGSGGVPSAFPSTIFESVWPLSTLLKVGYDLNSAPFIEKIRSYLHDAYIAEKGILGFTPFVGADADDTATTILVLNLLNQPVSVDAMLKEFEEEHHFKTYSQERNPSFSANCNVLLALLYSQEPSLYSAQIEKAIRFLYKQFTDSEMDVRDKWNLSPYYSWMLMTQAITRLTTLQKTSKLSTLRDDSISKGLISLLFRIASTVVKDQKPGGSWGTRASKEETAYAVLILTYAFYLDEVTESLRHDIKIAIENGCSFLSERTMQSDSEWLWVEKVTYKSEVLSEAYILAALKRAADLPDENAEAAPVINGISTNGFEHTDRINGKLKVNGTNGTNGSHETNGINGTHEIEQINGVNGTNGHSDVPHDTNGWVEEPTAINETNGHYVNGTNHETPLTNGISNGDSVSVHTDHSDSYYQRSDWTADEEQILLGPFDYLESLPGKNMRSQLIQSFNTWLKVPTESLDVIIKVISMLHTASLLIDDIQDQSILRRGQPVAHSIFGTAQAMNSGNYVYFLALREVQKLQNPKAISIYVDSLIDLHRGQGMELFWRDSLMCPTEEQYLDMVANKTGGLFCLAIQLMQAEATIQVDFIPLVRLLGIIFQICDDYLNLKSTAYTDNKGLCEDLTEGKFSFPIIHSIRSNPGNRQLINILKQKPREDDIKRYALSYMESTNSFEYTRGVVRKLKTEAIDTIQGLEKHGLEENIGIRKILARMSLEL

Copalyl diphosphate synthase (CPS) (Bifunctional diterpene synthase PvCPS) [Includes: Type II terpene cyclase (EC 5.5.1.12); Geranylgeranyl diphosphate synthase (GGDP synthase) (GGS) (EC 2.5.1.29)]

Talaromyces verruculosus (Penicillium verruculosum)

198,730

963

108,180

3D-structure;Isomerase;Isoprene biosynthesis;Magnesium;Metal-binding;Multifunctional enzyme;Transferase

GO:0004659; GO:0008299; GO:0016853; GO:0043386; GO:0046165; GO:0046872

Evidence at protein level

5

null

PF00348;

IPR008949;IPR000092;IPR033749;IPR008930;

6V0K;7S09;7S0A;7S0H;7S0L;7S0M;

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Ascomycota (phylum), saccharomyceta (clade), Pezizomycotina (subphylum), leotiomyceta (clade), Eurotiomycetes (class), Eurotiomycetidae (subclass), Eurotiales (order), Trichocomaceae (family), Talaromyces (genus), Talaromyces sect. Talaromyces (section)

PvCPS

false

435

A0A383ZFX3

MLGRSRLTFVLLSVTVTCSVAQHVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKRWHELMVDKAPALKVIVNYLKNMINAFEPSGKIVQLVDQKLPGLLGSFPGPFEEEMKGIAAVTEIPLGEIILFNIFYEFFTICTSIITEDKEGHLLHARNMDFGVFLGWNVNNNTWVVTEELKPLTVNLDFQRNSKTVFKAAGFAGYVGMLTGFKPGLFSLTLNERFSTNGGFMGVIEWILGKKDAKWIGFIIRSVLENSTSYEEAKTILTKSKILAPAYFILGGSKSGEGCVITRDRVQSLDIYELDPKQGIWYVVQTNYDRWKNPFFLDNRRTPAKMCLNRTTQENISFATMYDVLSTKPVLNKLTVYTALIDVTKGQFETYLRDCPDPCIGW

Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylethanolamine hydrolase ASAH1) (EC 3.5.1.-) (N-acylsphingosine amidohydrolase) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta]

Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)

310,752

395

44,743

3D-structure;Disulfide bond;Glycoprotein;Hydrolase;Lipid metabolism;Lysosome;Reference proteome;Secreted;Signal;Sphingolipid metabolism;Zymogen

GO:0005576; GO:0005764; GO:0006631; GO:0006665; GO:0016020; GO:0017040; GO:0017064

Evidence at protein level

5

SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q13510}. Secreted {ECO:0000250|UniProtKB:Q13510}. Note=Secretion is extremely low and localization to lysosomes is mannose-6-phosphate receptor-dependent. {ECO:0000250|UniProtKB:Q13510}.

SIGNAL 1..21; /evidence="ECO:0000255"

null

PF02275;PF15508;

IPR016699;IPR029130;IPR029132;

5U84;

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Mammalia (class), Theria (clade), Eutheria (clade), Boreoeutheria (clade), Laurasiatheria (superorder), Artiodactyla (order), Whippomorpha (suborder), Cetacea (infraorder), Mysticeti (parvorder), Balaenopteridae (family), Balaenoptera (genus), Balaenoptera acutorostrata (species)

ASAH1

false

436

A0A384J6C4

MRSSTISASAVVLLSGLASAQTFTDCNPTEKTCPSDPAIGGLQVTDFTAGKSSYWEVEDGTTMSYDGTLGAQFVISTATDAPTIKNIGYIMFGRIETWVRASAGTGIVSSFILESDDLDEIDWEWLGANNAEAENNFFGKGNTTTYDRAQYPAVATPIDTFHNYTIDWTAKSTIWYIDGVAVRTLLYDDKQTVGGKNYPQTPMLVKMGSWIGCASKAAETDSATAGTCSWAGGAVDLTQGPFTMYVKNVTIQDYGCATEYTYGDLTGDYTSIKATGGCSADGSAASPSASSSSAASGSSSSTKSSSGSSTLSTVTGTTSAIAVGTATGTATLSAGEKATAAAISGSTTSSSTIAKVTTTSDANSLKKPKHEYGMIDLGVMVLGLGLGYLVM

Crh-like protein 1 [Includes: Chitinase crh1 (EC 3.2.1.14); Chitin transglycosylase crh1 (EC 2.4.-.-)]

Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)

332,648

391

40,365

Cell wall biogenesis/degradation;Disulfide bond;Endoplasmic reticulum;Glycoprotein;Glycosidase;Glycosyltransferase;GPI-anchor;Host cytoplasm;Hydrolase;Lipoprotein;Membrane;Reference proteome;Secreted;Signal;Transferase;Vacuole

GO:0004553; GO:0005975; GO:0009277; GO:0016757; GO:0031505; GO:0098552

Evidence at protein level

5

SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}. Vacuole {ECO:0000269|PubMed:33846308}. Endoplasmic reticulum {ECO:0000269|PubMed:33846308}. Secreted {ECO:0000269|PubMed:33846308}. Host cytoplasm {ECO:0000269|PubMed:33846308}. Note=Under saprophytic conditions, is localized inside vacuoles and the endoplasmic reticulum (PubMed:33846308). During pathogenic development, high levels of the protein are observed in developing infection cushions, before being secreted to the plant apoplasm (PubMed:33846308). {ECO:0000269|PubMed:33846308}.

SIGNAL 1..20; /evidence="ECO:0000255"

null

PF00722;

IPR013320;IPR000757;IPR017168;IPR050546;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Ascomycota (phylum), saccharomyceta (clade), Pezizomycotina (subphylum), leotiomyceta (clade), sordariomyceta (clade), Leotiomycetes (class), Helotiales (order), Sclerotiniaceae (family), Botrytis (genus), Botryotinia fuckeliana (species)

crh1 BCIN_01g06010

false

437

A0A384K116

MVGKSTLLSVLASASVAFAACSLDSHCPEETPCCSQYGECGTGAYCLGGCDPRMSFSLESCVPEPVCESASYTFTSMDGITSNTKYLGDASKSNWVYSGSPVIYNDNVLLTMSANSVGTVMASSTYMWYGNVKAKFKTSRGQGVITAFILFSDVKDEIDYEFVGSELTTAQSNYYFQGITNYDNELNITLSDTYANYHEYEIDWTPDEITWLVDGQVGRTKKRADTWNATANQWNFPQTPARVQLSLWPGGLASNGAGTIAWAGGEIDWNSEDIQNNGYYYAAFESVDISCYNAKSAPGTNSGKSYYYNSVLGTNNTVIDSKNATILSSLLATGTNMTAGESAAASGSTAASTAATVPGLTGSGGGGVGDNHSDDGSSSSDSSSGSATSSSSGSSSTGSSGFSQGDGSTSTSKSSADSLVANQERVLKGSLFAGIVAVVAMMAL

Crh-like protein 3 [Includes: Chitinase crh3 (EC 3.2.1.14); Chitin transglycosylase crh3 (EC 2.4.-.-)]

Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)

332,648

444

46,296

Cell membrane;Cell wall biogenesis/degradation;Disulfide bond;Glycoprotein;Glycosidase;Glycosyltransferase;GPI-anchor;Hydrolase;Lipoprotein;Membrane;Reference proteome;Signal;Transferase

GO:0000144; GO:0004553; GO:0005975; GO:0006030; GO:0009277; GO:0016757; GO:0031505; GO:0098552

Evidence at protein level

5

SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}.

SIGNAL 1..19; /evidence="ECO:0000255"

null

PF00722;

IPR013320;IPR000757;IPR017168;IPR050546;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Ascomycota (phylum), saccharomyceta (clade), Pezizomycotina (subphylum), leotiomyceta (clade), sordariomyceta (clade), Leotiomycetes (class), Helotiales (order), Sclerotiniaceae (family), Botrytis (genus), Botryotinia fuckeliana (species)

crh3 BCIN_13g03640

false

438

A0A386CAB9

MSSDYTDRNNLASAIKTLGDMLEKDEAFQRLMYNASTKGEINRGRVNKVFLKALLSAGDKVGEFLNELIDHLNLFKVLGDFSWNPPVLKEAELNERTSQLRTQQHKYVERVSGFSHYGFGETGTPARGDITSPRGPQVASIEEDLATSKLAELLLAVGDHLEKIEKKGQFLPENVERFSLDCFITSESVKLSSEAVELAPCYTEPVIIQRSKEQTEKYCQEYVRSPHTSSHLLSNDKTQSIRIGQLFSPDSDGNTPKTVILCGDSGRGKSFVLEKIILDWVHLEHHFENFDAVFLLKYEELKCLSEEMSLTELLSRSCSLTSDQISQILQLTPEKVLFLIDGIDDFSFNAHIQISSPTDPSQKAPVISIIHCLMRDLLLVESSVIVTTRYTAAAELSSLCKRPQRFTEIEGFSERRVQEYFQKFFQDEQLFKKAYESMKTNETLLTFCSVPLLCWMVCFCLKKDADQVMTELKTTTSIYVHFVSTLLEDHHQSQSFLRSLGQLAEEGMKNRQNLFDEKSVTRTGLDPATRVFMNKIYLKRKKKHELLFKFKHLSFQEFFAALYYIMLDEEESWCKVSELFNMMESEALIHRSPPIFRGRLSNPIPSVMMFLCGLFNKKVSSSLFEKMKSTFSHNVKLKKKELKKKLMKMIPAMIRQYGFELFALHCLYELQDERFVTKVLETHKFIDLSNVSLRSTDCLVLCYCLRLCPNIRELNFMNCDLTAAKLKILQPALGLCETLRFSVEHLSEIGDLIQILSESKILRELKVREDEYGVESPRWSFNLSVTRGDVLLTLSSSEKNPSFSSVLNIRLTCAQSQISRTDWTLFLQRLRKTGTLTEDSSADDDHVSLQLSSLHSVGLKSLDLTLVSLNESWASGIISLIQNCTSLQQLKVSVTGLLLEEGLKLLKKSLTDPHCTVIIEGRRNCSEPSEEHLRQSYEKVEIHFKPKLLEELAELSICNPGSSALNIHCQSCVDVADSDQWVQVEPSVCRGEGGTEFRITTPAGRFQCSRTRMRWVCDGDVTLHYRAVDGHFLNAELERLQCERVAPVLDVNVISGKLEEAHLPHYMCLAESDPALTNAVKLLSVEDEGISLESVELTRFHAKILQPMFSPKTVLVKLGIPVKVHCDLLIFMTHTCPIILNVYFFPSDSLVEENIKTEEKSSHQIKCSRPEAPLQMKKQHSLEVPDAVVQPEAIKLRGNMKPNFFQVKQPVVNDITMILSRVDDQKSVWTGTIWKKLIDIKLNKTESDLFQSGQKHKTSQPAHSFDKAQFFDTHWCNLIKSVENVDTVADKLLQKQIIHEQFYSEIIHHKSTSEESMRKICVIVRKGSAAVKEIFISILLQENPNLLNHLPSSDS

NACHT, LRR and PYD domains-containing protein 1 homolog (EC 3.4.-.-) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)]

Danio rerio (Zebrafish) (Brachydanio rerio)

7,955

1,355

154,257

ATP-binding;Cytoplasm;Hydrolase;Immunity;Inflammasome;Inflammatory response;Innate immunity;Necrosis;Nucleotide-binding;Protease;Reference proteome;Repeat;Ubl conjugation

GO:0002221; GO:0005524; GO:0005737; GO:0006508; GO:0006954; GO:0008233; GO:0012501; GO:0032731; GO:0042981; GO:0045087; GO:0050729; GO:0061702; GO:0072558

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30150286}. Note=Co-localizes with pycard, caspa and caspb in the cytoplasm. {ECO:0000269|PubMed:30150286}.; SUBCELLULAR LOCATION: [NACHT, LRR and PYD domains-containing protein 1, C-terminus]: Inflammasome {ECO:0000269|PubMed:30150286}.

null

PF00619;PF13553;PF05729;PF17776;PF17779;PF23679;

IPR001315;IPR011029;IPR025307;IPR032675;IPR007111;IPR041267;IPR050637;IPR041075;IPR027417;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Actinopterygii (superclass), Actinopteri (class), Neopterygii (subclass), Teleostei (infraclass), Osteoglossocephalai (clade), Clupeocephala (no rank), Otomorpha (cohort), Ostariophysi (subcohort), Otophysi (clade), Cypriniphysae (superorder), Cypriniformes (order), Cyprinoidei (suborder), Danionidae (family), Danioninae (subfamily), Danio (genus)

nlrp1 si:ch211-66k16.28

false

439

A0A386KZ50

MKFATSIVAAIATTGAAFTVIPQKLSHPSQLNALNTMGSISSITAESPKEVLSRVQDAGLTLTNPNDLYWMVDFLKEKYYDNGDYYYPIKTVCDGESIDVKFYCPFEPSLSPHYLELYGSRDERASIYETTMKKYNRINSEKTSAICTPYSSYGDTQIVAYFYSMMYYINDQTAHLKLPESEIESELIDILNDDILIYLNEFMSIFEPEDAQDLERIWDFLDFYQPYFSKVDGKIVLDEKYLVRTPSQMPLIKTICEYVSEQFAPSKNITQVIWEVVRYIKGVKDEIHIRGDKSFTLSLQEYDDFRDKVTASPMAHAVSDLTHERFSYEAYTNPAFMELENRCSEIITYFNDVCTSDRERLDEDPFNSVFILMDLDPSLNFAKSCDVVVEHAYNKMQAFLKLKEEILESASDEEERLALARMIKTREDSLIGYVLHEVCCVEDGYARDHKPLMKAFLEEEITKSLAEKVKFNPVESESVRLN

Magnesium-dependent glutamate N-prenyltransferase (EC 2.5.1.-) (Domoic acid biosynthesis cluster protein A) (PmDabA)

Pseudo-nitzschia multiseries (Marine planktonic diatom) (Nitzschia pungens f. multiseries)

37,319

482

55,647

3D-structure;Magnesium;Metal-binding;Transferase

GO:0016036; GO:0016740; GO:0046872; GO:0071244

Evidence at protein level

5

null

PF19086;

IPR008949;

6VKZ;6VL0;6VL1;

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Stramenopiles (clade), Ochrophyta (clade), Bacillariophyta (phylum), Bacillariophyceae (class), Bacillariophycidae (clade), Bacillariales (order), Bacillariaceae (family), Pseudo-nitzschia (genus)

dabA

false

440

A0A396GMX6

MKREHKLEHEDMSSGSGKSGVCWEDDGGGMDELLAVVGYKVKSSDMAEVAQKLEQLEQAMMGNNFHDHDESTIAQHLSNDTVHYNPSDISNWLQTMLSNFDPQPNNPSVNSDDNDLNAIPGKAIYAADEFTSRKRVKRNESVTVTTESTTTRPIMVVETQEKGIRLVHSLMACAEAVEQNNLKMAEALVKQIGYLAVSQEGAMRKVATYFAEGLARRIYGVFPQHSVSDSLQIHFYETCPNLKFAHFTANQAILEAFQGKSSVHVIDFSINQGMQWPALMQALALRPGGPPAFRLTGIGPPASDNSDHLQQVGWRLAQFAQTIHVQFEYRGFVANSLADLDASMLELRSPETESVAVNSVFELHKLNARPGALEKVFSVIRQIRPEIVTVVEQEANHNGPAFLDRFTESLHYYSTLFDSLEGSSVEPQDKAMSEVYLGKQICNVVACEGTDRVERHETLNQWRNRFNSAGFSPVHLGSNAFKQASMLLALFAGGDGYKVEENDGCLMLGWHTRPLIATSAWKLAAANSVVVSH

DELLA protein 2 (MtDELLA2)

Medicago truncatula (Barrel medic) (Medicago tribuloides)

3,880

533

58,991

Gibberellin signaling pathway;Nucleus;Reference proteome;Transcription;Transcription regulation;Ubl conjugation

GO:0003700; GO:0005634; GO:0006355; GO:0009610; GO:0009723; GO:0009737; GO:0009740; GO:0009863; GO:0009867; GO:0009938; GO:0010187; GO:0016036; GO:0036377; GO:0042538; GO:0043565; GO:0045944; GO:2000033; GO:2000377

Evidence at transcript level

5

SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A0A396IUP1}.

null

PF12041;PF03514;

IPR038088;IPR021914;IPR005202;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), rosids (clade), fabids (clade), Fabales (order), Fabaceae (family), Papilionoideae (subfamily), 50 kb inversion clade (clade), NPAAA clade (clade), Hologalegina (clade), IRL clade (clade), Trifolieae (tribe), Medicago (genus)

DELLA2 MtrunA17_Chr8g0376381

false

441

A0A396IUP1

MKREHQESFGGGVISNNNKTNTNHLNSSKNINFGECSSMQNTNTKQNMWREEKETNGGGMDELLAALGYKVRSSDMADVAQKLEQLEMVMGSAQEEGINHLSSDTVHYDPTDLYSWVQTMLTELNPDSSQINDPLASLGSSSEILNNTFNDDSEYDLSAIPGMAAYPPQEENTAAKRMKTWSEPESEPAVVMSPPPAVENTRPVVLVDTQETGVRLVHTLMACAEAIQQKNLKLAEALVKHISLLASLQTGAMRKVASYFAQALARRIYGNPEETIDSSFSEILHMHFYESSPYLKFAHFTANQAILEAFAGAGRVHVIDFGLKQGMQWPALMQALALRPGGPPTFRLTGIGPPQADNTDALQQVGWKLAQLAQTIGVQFEFRGFVCNSIADLDPNMLEIRPGEAVAVNSVFELHTMLARPGSVEKVLNTVKKINPKIVTIVEQEANHNGPVFVDRFTEALHYYSSLFDSLEGSNSSSNNSNSNSTGLGSPSQDLLMSEIYLGKQICNVVAYEGVDRVERHETLTQWRSRMGSAGFEPVHLGSNAFKQASTLLALFAGGDGYRVEENNGCLMLGWHTRSLIATSAWKLPQNESK

DELLA protein 1 (MtDELLA1)

Medicago truncatula (Barrel medic) (Medicago tribuloides)

3,880

594

65,226

Gibberellin signaling pathway;Nucleus;Reference proteome;Transcription;Transcription regulation;Ubl conjugation

GO:0003700; GO:0005634; GO:0006355; GO:0006357; GO:0009610; GO:0009723; GO:0009737; GO:0009740; GO:0009863; GO:0009867; GO:0009938; GO:0010187; GO:0016036; GO:0036377; GO:0042538; GO:0043565; GO:0045944; GO:2000033; GO:2000377

Evidence at protein level

5

SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24297892}.

null

PF12041;PF03514;

IPR038088;IPR021914;IPR005202;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), rosids (clade), fabids (clade), Fabales (order), Fabaceae (family), Papilionoideae (subfamily), 50 kb inversion clade (clade), NPAAA clade (clade), Hologalegina (clade), IRL clade (clade), Trifolieae (tribe), Medicago (genus)

DELLA1 MTR_3g065980 MtrunA17_Chr3g0110971

false

442

A0A396JG59

MHKKQLMALLMVPQTSDSQDATITKLESAYSDLESLLRSSKQMEQNIETMETRFDLLHGSITTASRRVHPLQSLSMSRKALDTRINRAISPALALLETFKLAESLQNNLLNLSSKLSTEKTHQKRLSKLLDYMDCVDQLNEAINSISEVVEPVIMRLQEVVEFISRTKAADQYRTQRLREALITLKALYETEVDEMRFEGLLDQALLHMQDEFEVLLLKLKHRKLGDMSHMQNGGEDCDDHFEVSFELGSELEIEVLRRISNTLAANDCLDICIDIYVKVRYKRAAKALMKLNPDYLRTYTPEGIDEMEWENLETSITLWTQHFEVATKKVLLSEKKLCESVLGEIIDGLIHPECFVKISDKIMAVFFRFGEGVARSNKEPQKLFKLLDMFESLEKLKPYVLEIFDGESGEDICARFRELEKLIIDASSKVFWEFGLQIEGNVDGFLPPPQDGSVPKIVRYAVNYLKYLSTENYRTTMAKVLRTELTWKTELMLSSKQSETDEDLLKHAICNVMEALQRNIESKRLSCKDKILVNIFMMNTYWYMYMRTKNTELGDLLGEKYIKESYKAVAEESAYLYQKQAWLVLVKILDQDDDDIKEQKQGKEKSIGRLVNEKIETFFKCLSEICDRHRSFYSIPDVDLREQMRDSTVKLLVPVYAEFLESYSGFLQRKVYPSPQRLQGLLGKAFGSTNDWNLNGGRNSGSLETDIRRSR

Exocyst complex component EXO70I (MtExo70I) (Exocyst subunit Exo70 family protein I)

Medicago truncatula (Barrel medic) (Medicago tribuloides)

3,880

712

82,325

Cell membrane;Coiled coil;Exocytosis;Glycoprotein;Membrane;Protein transport;Reference proteome;Signal;Transport

GO:0000145; GO:0005546; GO:0005886; GO:0006887; GO:0009609; GO:0009610; GO:0015031; GO:0036377; GO:0085042

Evidence at protein level

5

SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26234213}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=During arbuscule branching, restricted to zones adjacent to the periarbuscular membrane (PAM) around the arbuscule hyphal tips. {ECO:0000269|PubMed:26234213}.

SIGNAL 1..18; /evidence="ECO:0000255"

null

PF03081;

IPR016159;IPR004140;IPR046364;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), rosids (clade), fabids (clade), Fabales (order), Fabaceae (family), Papilionoideae (subfamily), 50 kb inversion clade (clade), NPAAA clade (clade), Hologalegina (clade), IRL clade (clade), Trifolieae (tribe), Medicago (genus)

EX70I MTR_1g017910 MtrunA17_Chr1g0152401

false

443

A0A3F2YLY8

MKKPVKSWLIASTVAALLAVPAVSQANSEVEKLTKNPANWATWGGNYHGTRYSELKQINTSNVKNLQPAWTFSTGVLRGHEGGPLVVNDVMYIHTPFPNTVYAIDQKTQAVIWEYTPQQDADVTIPVMCCDTVNRGLAYGDGKIFLQQSDTVLTALDAKTGKRVWSVQNGDPKLGMTNTQAPLVVKDKVITGISGGEFGVRGFLAAYNIRTGELDWKGYSMGPDADTLINPTKTTTWKDGKVQPVGKDSSTSTWEGDQWKIGGGTTWGWYSYDPELNLVYYGSGNPSTWNPAQRPGDNKWSMSLWARNADTGEVKWVYQMTPHDEWDYDGINEVALVDQEIKGQMRKTAVHFDRNGFGYTLDRVTGELLVAEKFDKAVNWASHVDMKSGRPQVVSQYSTEYNGEDVNTEGVCPAALGSKNQQPVSYSPQTGYFYISGNHVCMDYEPFEVEYTAGQPYVGATLSMFPAGKDVITGKEDGSNNLGQFTAWDATTGKIIWSNKEQFSVWSGSLATAGGVVFYGTLEGYLKAVDAKTGKELYRFKTPSGIIGNVNTWEYEGKQYVGVLSGVGGWAGIGIAAGLDSGEESSNSEGLGAVGAYRSLSSYTKLGGTLTVFALPN

Lanthanide-dependent methanol dehydrogenase XoxF (Lanthanide-dependent MDH) (Ln(3+)-dependent MDH) (EC 1.1.2.10)

Methylotuvimicrobium buryatense (Methylomicrobium buryatense)

95,641

617

67,220

3D-structure;Disulfide bond;Metal-binding;Methanol utilization;Oxidoreductase;Periplasm;PQQ;Signal

GO:0005509; GO:0015945; GO:0016020; GO:0016614; GO:0030288

Evidence at protein level

5

SUBCELLULAR LOCATION: Periplasm {ECO:0000305|PubMed:30132076}.

SIGNAL 1..26; /evidence="ECO:0000255"

null

PF01011;

IPR018391;IPR017512;IPR002372;IPR011047;IPR001479;

6DAM;

cellular organisms (no rank), Bacteria (domain), Pseudomonadati (kingdom), Pseudomonadota (phylum), Gammaproteobacteria (class), Methylococcales (order), Methylococcaceae (family), Methylotuvimicrobium (genus)

xoxF EQU24_18605

false

444

A0A3L7I2I8

MQFFGRLVNTLSSVTNLFSNPFRVKEISVADYTSHERVREEGQLILFQNASNRTWDCILVSPRNPHSGFRLFQLESEADALVNFQQFSSQLPPFYESSVQVLHVEVLQHLSDLIRSHPSWTVTHLAVELGIRECFHHSRIISCANSTENEEGCTPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNSQVLQLLGKNASAGLNQVNKQGLTPLHLACQMGKQEMVRVLLLCNARCNVMGPSGFPIHTAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCDVDSTSAAGNTALHVAVMRNRFDCVMVLLTYGANAGTPGEHGNTPLHLAISKDNMEMIKALIVFGAEVDTPNDFGETPAFMASKISKLITRKALLSLLRTVGADHRFPLIQGVPTDQSSAATPHPIFSLDKTQPPAISLNNLELQDLMPISRARKPAFILSSMRDEKRIHDHLLCLDGGGVKGLVIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYDAPEVIREPRFNQNINLKPPTQPADQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDMIRKGQGNKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWSEMVGIQYFRLNPQLGSDIMLDEVNDAVLVNALWETEVYIYEHREEFQKLVQMLLSP

85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (2-lysophosphatidylcholine acylhydrolase) (EC 3.1.1.5) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (PLA2G6) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9)

Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

10,029

807

89,776

3D-structure;Alternative splicing;ANK repeat;Cell membrane;Cell projection;Cytoplasm;Hydrolase;Lipid metabolism;Membrane;Mitochondrion;Phospholipid metabolism;Repeat;Transmembrane;Transmembrane helix

GO:0003847; GO:0004622; GO:0005615; GO:0005739; GO:0005886; GO:0015630; GO:0016607; GO:0017171; GO:0019731; GO:0031143; GO:0034638; GO:0035774; GO:0035965; GO:0042802; GO:0046338; GO:0046469; GO:0046473; GO:0047499; GO:0052816; GO:2000304

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O60733}. Cell membrane {ECO:0000250|UniProtKB:O60733}. Mitochondrion {ECO:0000250|UniProtKB:P97819}. Cell projection, pseudopodium {ECO:0000250|UniProtKB:O60733}. Note=Recruited to the membrane-enriched pseudopods upon MCP1/CCL2 stimulation in monocytes. {ECO:0000250|UniProtKB:O60733}.

null

TRANSMEM 481..501; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 512..532; /note="Helical"; /evidence="ECO:0000255"

PF12796;PF01734;

IPR016035;IPR002110;IPR036770;IPR047148;IPR002641;

6AUN;

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Mammalia (class), Theria (clade), Eutheria (clade), Boreoeutheria (clade), Euarchontoglires (superorder), Glires (clade), Rodentia (order), Myomorpha (suborder), Muroidea (clade), Cricetidae (family), Cricetinae (subfamily), Cricetulus (genus)

PLA2G6 PLPLA9

false

445

A0A3Q0KDV9

MTADVLKALPPDVRTLKLSGHVGFDSLPDQLVNKAISQGFVFNILCVGETGIGKSTLLETLFNQKFDFSPSNHDLTDPKLKAVTYDLKEANVKLKLTVVETCGYGDQINKENNIKPVVDYIDNQFENYLQEELKMKRSMQAFHDTRVHVCLYFIAPTGHSLKSIDLVAMKKLENKVNVIPVIAKSDTITKSELQKFKARILSEIQSNEIGIYQFPTDDEAVSETNSVMNQHIPFAVVGSSEEVKINGKTVRVRQYPWGSVQVENENHCDFVRLREMLLRVNMEDLRERTHGVHYETYRRQRLIEMGFRDDEKMSLQETYEKRRELQRKELQQKEEEMRQMFVQRVKEKEQVLKEAERELQTKFESLKKTHAEEKKKLEEKKRFLEEEIAAFERRKQLAEQARQGNLTMKKRK

Septin-10 (SmSEPT10)

Schistosoma mansoni (Blood fluke)

6,183

412

48,090

3D-structure;Coiled coil;Cytoplasm;Cytoskeleton;Direct protein sequencing;Glycoprotein;GTP-binding;Magnesium;Metal-binding;Nucleotide-binding;Reference proteome

GO:0000287; GO:0005525; GO:0019003; GO:0031105; GO:0031982; GO:0042802; GO:0042803; GO:0046982; GO:0051260

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8C1B7}. Note=Colocalizes with actin in the longitudinal and circular muscles of the sporocyst. {ECO:0000269|PubMed:24367716}.

null

PF00735;

IPR030379;IPR027417;IPR016491;

4KV9;4KVA;

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Spiralia (clade), Lophotrochozoa (clade), Platyhelminthes (phylum), Trematoda (class), Digenea (subclass), Strigeidida (order), Schistosomatoidea (superfamily), Schistosomatidae (family), Schistosoma (genus)

SEPT10 Smp_029890

false

446

A0A3Q0KGQ7

MLYDFASWYRRWRFGEGKRIDLVLIGPPGSGKGTQAVKIAERYNICHLSTGDILRAIIASGSELGQKVQKITESGGLVSDDIVCDLIAQKINSPECKNGLLFDGFPRTIEQAKKLDNLLRDRQIHLLAALEFKLDPSILEKRICGRLFHLASGRSYHELFNPPKVPMVDDITGDRLVHRSDDKPEALKKRLYEYDKNVAPILHFYESQNKLLRINANKDVNQVFSDIQELVRTKLAEEK

Adenylate kinase 2 (ADK2) (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (SmADK2)

Schistosoma mansoni (Blood fluke)

6,183

239

27,202

ATP-binding;Cytoplasm;Kinase;Nucleotide biosynthesis;Nucleotide-binding;Purine salvage;Reference proteome;Transferase

GO:0004017; GO:0005524; GO:0005737; GO:0005829; GO:0006166; GO:0006172; GO:0006756; GO:0016208; GO:0046083

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P07170}.

null

PF00406;PF05191;

IPR006259;IPR000850;IPR033690;IPR007862;IPR027417;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Spiralia (clade), Lophotrochozoa (clade), Platyhelminthes (phylum), Trematoda (class), Digenea (subclass), Strigeidida (order), Schistosomatoidea (superfamily), Schistosomatidae (family), Schistosoma (genus)

Smp_061940

false

447

A0A3Q0KJ78

MVKPDGVQRGLVGEVIQRFERRGYKLVAIKMMHASEQLLQTHYEALKSLSFFPKLVAYMSSGPVVPMVFEGRKVVENGRTMLGATKPEASCPGSIRGDYCQDVGRNVVHGSDSTESANREINLWFSPQELCQYKQAVDPWIHE

Nucleoside diphosphate kinase (NDK) (NDP kinase) (NDPK) (EC 2.7.4.6) (SmNDPK)

Schistosoma mansoni (Blood fluke)

6,183

143

16,072

3D-structure;ATP-binding;Kinase;Magnesium;Nucleotide biosynthesis;Nucleotide-binding;Purine salvage;Reference proteome;Transferase

GO:0004550; GO:0005524; GO:0006166; GO:0006183; GO:0006228; GO:0006241; GO:0009202; GO:0032261; GO:0034214; GO:0042802; GO:0043531

Evidence at protein level

5

null

PF00334;

IPR034907;IPR036850;IPR001564;

5IOL;5IOM;5KK8;

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Spiralia (clade), Lophotrochozoa (clade), Platyhelminthes (phylum), Trematoda (class), Digenea (subclass), Strigeidida (order), Schistosomatoidea (superfamily), Schistosomatidae (family), Schistosoma (genus)

Smp_092750

false

448

A0A3Q0KQY7

MLETDSQRLRVVEDSLGKINVPLERYYGAQTARSLGNFNVCTRSDTMPLQIVYSLAMIKEVAACTNFKLGRISSKLSDAIVKACREVYHGQHDNEFPLVIWQTGSGTQTNMNVNEVLSSRASELIDGSRSSRLTVHPNDHVNLGQSSNDIFPTAMNLSIAMETAWKVLPSLNHLINVLKIKMHEFMNVIKIGRTHMQDAVPMSVGQELSGYVSQLQQAVDSIKSQLPLICHLAVGGTAVGTGLNCSKGFDEELCVSLTQLTDRLYRTMYKESTPVVDLIFKPAENKFAALAGHDALLQLSGCFNTTATALMRLSNDFCLLSSGPNCGLSEFVLPANEPGSSIMPGKVNPTQCESLRMVCLQIMGNHFTTSMAASQGQLELNVCKPLIAANLLHTCELLTDSTRCFADKCVRDLQLNREKIQEYVDKSLMLVTVLTPHIGYDLSAKLVQHASKFKKGLRESAIELNLLCGEKFDEIVKPMEMAFPHNNK

Fumarate hydratase (Fumarase) (EC 4.2.1.2) (Class II fumarase) (SmFHII)

Schistosoma mansoni (Blood fluke)

6,183

488

53,776

3D-structure;Cytoplasm;Lyase;Reference proteome

GO:0000050; GO:0004333; GO:0005739; GO:0005829; GO:0006099; GO:0006106; GO:0006108; GO:0006525; GO:0051289

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P07954}.

null

PF10415;PF00206;

IPR005677;IPR024083;IPR018951;IPR020557;IPR000362;IPR022761;IPR008948;

6U4O;

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Spiralia (clade), Lophotrochozoa (clade), Platyhelminthes (phylum), Trematoda (class), Digenea (subclass), Strigeidida (order), Schistosomatoidea (superfamily), Schistosomatidae (family), Schistosoma (genus)

Smp_158240

false

449

A0A3Q0KR05

MPQSTAQLKSPLLHTLLENLTQSSICTSTAIWHVPNPVNFVCNHNENSFDNKNNSVTTITTTDVSTNNHKNTNYDYEQQEQWSNEEINSNQESNEIYTMTFLKLNNAANRVAMNLANYLERKWSSITNKINRTQLNQHSLSIDEPIELRNQSDTVIALFMPPGIDRIVVQIACMKLHLAYMPLDRNVPAGRITQILHKLKPILILIDKDYYDFIYDDDHNDNDKMSDLSSSIDNNNKSLLSRKLSSNDFIIGNLNQLKLTFQLFDVKVYEYIKLMKLSKYYSRSDIYTASIPIRVCLFPFESDPIVLVLFTSGSTSSGPKPVKLRTTQLFNRLEWQWDSTSDMDLPNFENATCNSNTSVKRIGLAKTAWGFVDAFTELFSCLLAGIPVVVPGGSACPSEKSITDVQQLINLTKHFKISHITTVPTQMNLWLKQLRLKPKEIVTSHLSSLRTVIVSGDIVHPKMACEFFQLFKNPEMRLINLYGTTEVAGDVTGLVFRGEIDVKKHTKVVPCGLERENNKSGKPVLSVGTVIQGTAIFIVQDDDDHHLHHEKDNENQPDKWSNPSLSIIGSVDRKPNWDKFPFKILPKGHIGHVCILGQQVSDSASRCQRIESLPEDLNCVDTNKCKSDVESCENNSSKEIRVFMPGDLGFIDPQTNHLYICGRTNELIKINGIRFHANDIDNLFIELKKNWKAKNMTNCTREELLVNKVSETVTLTIQTVHGRDLKLVCFYVLHMNENQNTMNIEPKENYDKLEDLPKQDDFIAVFSHYLPPYLSPTFINIDHIPLMRTSGKVDKEYLRQYYYSKHHCEISEITKVLQPGWVNDPVKHMTENNNSTSDQSFGKNSRDFKLSRGRERARKVLAEVLGIRGPNGDVIPGRPKDDEDFYLLGGDSLLTVLTTEQLRQLGFNVNLDVFTKTGKIGSILTSLQNTESDFLKTQEPFTSDSWTVKEISMNKVLKKSHTCNLINRIPLMEDECYLSPTICPQGSYEIFIEQWNDGNFSVTERHEIVDVLVNAFIEKDRLSHALKLDRTDLTEAIEVFLNAHKSNPGIVLTARYYYENPYEHTFVKNKLVGVIISLPAKHVPSLHLTPKLALVQRFFDECSNKDQFQDISMDNLLATQMVAITSQSPYSKSKYLQYMLSNWKKISLKLLTRLERDLLRIAAKQGYSGVITFNTNEVTEEVCSQLGYKVIQTTMLKSFMNKENLLLLPQYERIRCSYMIKELNPSS

Beta-alanyl-bioamine nonribosomal peptide synthetase (EC 6.3.2.-) (Nonribosomal peptide synthetase) (SmNRPS)

Schistosoma mansoni (Blood fluke)

6,183

1,227

140,064

Ligase;Phosphopantetheine;Phosphoprotein;Reference proteome

GO:0003833; GO:0030540; GO:0043042

Evidence at protein level

5

null

PF00501;PF00550;

IPR045851;IPR000873;IPR042099;IPR009081;IPR006162;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Spiralia (clade), Lophotrochozoa (clade), Platyhelminthes (phylum), Trematoda (class), Digenea (subclass), Strigeidida (order), Schistosomatoidea (superfamily), Schistosomatidae (family), Schistosoma (genus)

NRPS Smp_158480

false

450

A0A3Q0NBH7

MKIRWIRLSLVAILIIAVVFIGVIGFQKYQFSKSRNKVIMQMDRLMKDQDGGNFRRLDKKENGVEIISYIPKTTEKKDNEIIQKEIGKATDAEVKKLNRDKETQGIIFYTYQKHRMAEQAISYKAVQSEYVKEGRTKFVLKDKKDICKNIVTDAETGALLTLGEVLIKSNQTKLNLKTAVEEELIKTGDFSLKDVGNLGKIKSLVKWNQTDFEITNSEIILPVKIPGAPEPKKVKVKLADIASSVNKRYLPSSVKVPEVPKAKTNKRIALTFDDGPSSSVTPGVLDTLKRHNVKATFFVLGSSVIQNPGLVKRELEEGHQVGSHSWDHPQLTKQSTQEVYNQILKTQKAVFDQTGYFPTTMRPPYGAVNKQVAEEIGLPIIQWSVDTEDWKYRNAGIVTKKVLAGATDGAIVLMHDIHKTTAASLDTTLTKLKSQGYEFVTIDELYGEKLQIGKQYFDKTDSRMVK

Peptidoglycan-N-acetylglucosamine deacetylase PgdA (Peptidoglycan GlcNAc deacetylase) (EC 3.5.1.104) (N-acetylglucosamine de-N-acetylase PgdA) (Peptidoglycan N-deacetylase) (PG N-deacetylase) (Petptidoglycan deacetylase) (PG deacetylase)

Listeria monocytogenes serotype 1/2a (strain EGD / Mackaness)

1,334,565

466

52,496

Cell membrane;Cell wall;Hydrolase;Membrane;Metal-binding;Secreted;Transmembrane;Transmembrane helix;Virulence;Zinc

GO:0001896; GO:0005576; GO:0005886; GO:0005975; GO:0008270; GO:0009275; GO:0042545; GO:0042803; GO:0050119; GO:0060241; GO:0141043

Evidence at protein level

5

SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8Y9V5}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8Y9V5, ECO:0000255}; Extracellular side {ECO:0000250|UniProtKB:Q8Y9V5}. Secreted, cell wall {ECO:0000305|PubMed:19809250}.

null

TRANSMEM 6..26; /note="Helical"; /evidence="ECO:0000255"

PF01522;

IPR011330;IPR002509;IPR017219;IPR050248;

null

cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Bacillota (phylum), Bacilli (class), Bacillales (order), Listeriaceae (family), Listeria (genus), Listeria monocytogenes (species)

pgdA LMON_0423

false

451

A0A3Q2TTB3

MKRKWEERVKKVEELASYYERNPLPTVYKPRLSKPLQPSRVWKIFCRQADAFRFVKTCKEDVHVFALERNTQNGQRFYLVTTYQELWYYYTKGYKTSLMHCYEVIPEKDACKLYFDLEFYKAANPGADGKDMVAKLIELVSQKLKELYDVNCSARDVLNLDSSTDEKFSRHLIFLPCKTVFKDNIHVGNFVRTILQPAIRLVGSNVAAPIAEGGAGYTSQCSAPTVELDGPLTNLTAVEDASKGWPAIADQRKETETSHHGENSEFSFLIVNNKEGDKQLFVDLGVYTRNRNFRMYKSSKAGKNVILTIAEDNKFVPNCEENVSLEEAYFLSSLVCNVRFEDGTKILSSNFVEEEIKMSAFLRSKTTRSTREPMEGYQESPYPEIDCFVRSLINKDGVQGGIRQWNYFSGEEILVYDISGYRWCENIGRAHRSNNIMILVDLKKEVWYQKCHDPVCREKNFKSQSLPLPSRICLSSLFIEEEDHMVTDERENTEVTSHSNPADLSESSAYLAINTSQDTQWDNASDDAYLVETAEDVELAEAADYSLGYDTEEIPDEVLLEMSWKQDTCSKDDS

DNA-directed primase/polymerase protein (EC 2.7.7.102) (EC 2.7.7.7)

Gallus gallus (Chicken)

9,031

574

65,865

Alternative splicing;Chromosome;Coiled coil;DNA damage;DNA repair;DNA-directed DNA polymerase;DNA-directed RNA polymerase;Manganese;Metal-binding;Mitochondrion;Nucleotidyltransferase;Nucleus;Reference proteome;Transcription;Transferase;Zinc

GO:0000428; GO:0003682; GO:0003887; GO:0003899; GO:0005634; GO:0005657; GO:0005759; GO:0006264; GO:0008270; GO:0009411; GO:0019985; GO:0030145; GO:0031297; GO:0042276; GO:0043504; GO:0062176

Evidence at protein level

5

SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96LW4}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q96LW4}. Chromosome {ECO:0000250|UniProtKB:Q96LW4}.

null

PF03121;

IPR044917;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Sauropsida (clade), Sauria (clade), Archelosauria (clade), Archosauria (clade), Dinosauria (clade), Saurischia (clade), Theropoda (clade), Coelurosauria (clade), Aves (class), Neognathae (infraclass), Galloanserae (superorder), Galliformes (order), Phasianidae (family), Phasianinae (subfamily), Gallus (genus)

PRIMPOL

false

452

A0A3Q7FGP1

MADELNKAALEEYKSSSVEDRGEEGEIVGESDDTASSLGKQITMKHPLEHSWTFWFDNPSGKSKQAAWGSSIRPIYTFSTAEDFWSVYNNIHHPSKLAVGADFHCFKNKIEPKWEDPVCANGGKWTMNFSRGKSDTCWLYTLLALIGEQFDYGDEICGAVINVRVRQEKIALWTRNAANETAQVSIGKQWKEFLDYNDTIGFIFHDDAKKLDRAAKNRYSV

Eukaryotic translation initiation factor 4E-2 (eIF4E-2) (eIF-4F 25 kDa subunit) (eIF-4F p26 subunit) (mRNA cap-binding protein)

Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

4,081

221

25,104

Cytoplasm;Disulfide bond;Host-virus interaction;Initiation factor;Nucleus;Plant defense;Protein biosynthesis;Reference proteome;RNA-binding;Translation regulation

GO:0000340; GO:0003723; GO:0003743; GO:0005634; GO:0005737; GO:0006413; GO:0006417; GO:0016281; GO:0051607

Evidence at protein level

5

SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C6ZJZ3}. Cytoplasm {ECO:0000250|UniProtKB:C6ZJZ3}.

null

PF01652;

IPR023398;IPR001040;IPR019770;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), lamiids (clade), Solanales (order), Solanaceae (family), Solanoideae (subfamily), Solaneae (tribe), Solanum (genus), Solanum subgen. Lycopersicon (subgenus)

eIF4E2 Solyc02g021550

false

453

A0A3Q7GYG2

MASNNNICAYELIEAEAQSWDYILSYLRPSCIKCAIQLGIPDILHKNADPIMSLSDLIAALPNLNPSKTTFIPILMRVLVDFGLFNYHQQQGDGYSLTTVGRLLVENHHFGNRSFFLFAQHPVVLNTAASVGDWLKDDLRTAFETADGKSHWDYCGADPEFNGVFNDAMAGDSRLMSNLLISDCCAGVFEGLTSLVDIGGGTGAVAMAIAGAFPSLKCIVLDLPHVIADRKGSGNLEFVAGSMFDKIPHANAILLKWILHNWDDEDCVKLLKKCKESISSRENGGKVIIIDMIMEDNYNNKQLVQSQHLMDLIMRITYASKERTEKEWEKLFLEAGFSGYKIITSLGLRSLIEIYP

Myricetin 7/4'-O-methyltransferase 2 (SlMOMT2a) (SlMOMT2b) (EC 2.1.1.-) (3',4',5'-trimethyl myricetin 7-O-methyltransferase) (EC 2.1.1.-) (3',5'-dimethyl myricetin 7-O-methyltransferase) (7-O-methyl syringetin synthase) (Syringetin 7-O-methyltransferase) (EC 2.1.1.-) (3'-methyl quercetin 4'-O-methyltransferase) (4'-O-methyl isorhamnetin synthase) (Isorhamnetin 4'-O-methyltransferase) (EC 2.1.1.-) (3-methyl quercetin 7-O-methyltransferase) (EC 2.1.1.82) (4'-methyl kaempferol 7-O-methyltransferase) (7-O-methyl kaempferide synthase) (Kaempferide 7-O-methyltransferase) (EC 2.1.1.-) (7-methyl quercetin 4'-O-methyltransferase) (Rhamnacene synthase) (Rhamnetin 4'-O-methyltransferase) (EC 2.1.1.-) (Kaempferol 4'-O-methyltransferase) (Kaempferide synthase) (EC 2.1.1.155) (Myricetin 7-O-methyltransferase) (EC 2.1.1.-) (Quercetin 7-O-methyltransferase) (Rhamnetin synthase) (EC 2.1.1.-)

Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

4,081

356

39,490

Methyltransferase;Reference proteome;S-adenosyl-L-methionine;Transferase

GO:0008171; GO:0008757; GO:0009058; GO:0009813; GO:0032259; GO:0046983

Evidence at protein level

5

null

PF08100;PF00891;

IPR016461;IPR001077;IPR012967;IPR029063;IPR036388;IPR036390;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), lamiids (clade), Solanales (order), Solanaceae (family), Solanoideae (subfamily), Solaneae (tribe), Solanum (genus), Solanum subgen. Lycopersicon (subgenus)

MOMT2 Solyc06g064500

false

454

A0A3Q7HJG4

MGNIKFLLLVFFLIVVVVNGCWEEERNALLELQTNIMSSNGELLVDWAGYNAAHFVDCCFWDRVKCSLETGRVIKLDLEADFGTGDGWLFNASLFLPFKSLQVLLLSSQNIIGWTKNEGFSKLRQLPNLKEVDLQYNPIDPKVLLSSLCWISSLEVLKLGVDVDTSFSIPMTYNTNMMSKKCGGLSNLRELWFEGYEINDINILSALGELRNLEKLILDDNNFNSTIFSSLKIFPSLKHLNLAANEINGNVEMNDIIDLSNLEYLDLSDNNIHSFATTKGNKKMTSLRSLLLGSSYSNSSRVIRSLKSFSSLKSLSYKNSNLTSPSIIYALRNLSTVEYLYFKGSSLNDNFLPNIGQMTSLKVLNMPSGGNNGTLPNQGWCELKYIEELDFLNNNFVGTLPLCLGNLTSLRWLSLAGNNLHGNIASHSIWRRLTSLEYLDIADNQFDVPLSFSQFSDHKKLIYLNVGYNTIITDTEYQNWIPNFQLEFFAIQRCIALQKLPSFLHYQYDLRILAIEGNQLQGKFPTWLLENNTRLAAIYGRDNAFSGPLKLPSSVHLHLEAVDVSNNKLNGHIPQNMSLAFPKLLSLNMSHNHLEGPIPSKISGIYLTILDLSVNFLSGEVPGDLAVVDSPQLFYLRLSNNKLKGKIFSEEFRPHVLSFLYLNDNNFEGALPSNVFLSSLITLDASRNNFSGEIPGCTRDNRRLLQLDLSKNHLQGLIPVEICNLKIINVLAISENKISGSIPSCVSSLPLKHIHLQKNQLGGELGHVIFNFSSLITLDLRYNNFAGNIPYTIGSLSNLNYLLLSNNKLEGDIPTQICMLNNLSIVDLSFNKLYGPLPPCLGYLTQTKKDAEISWTYFAENYRGSWLNFVIWMRSKRHYHDSHGLLSDLFLMDVETQVQFSTKKNSYTYKGNILKYMSGIDLSSNRLTGEIPVELGNMSNIHALNLSHNHLNGRIPNTFSNLQEIESLDLSCNRLNGSIPVGLLELNSLAVFSVAYNNLSGAVPDFKAQFGTFNKSSYEGNPFLCGYPLDNKCGMSPKLSNTSNINGDEESSELEDIQCFYIGFVVSFGAILLGLAAALCLNRHWRRAWFRMIEALMFYCYYFVLDNIVTPIKSRWYKNVG

Cuscuta receptor 1 (CuRe1) (Leucine-rich repeat receptor-like protein Solyc08g016270) (LRR-RLP Solyc08g016270)

Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

4,081

1,121

126,156

Cell membrane;Glycoprotein;Immunity;Leucine-rich repeat;Membrane;Plant defense;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix

GO:0002218; GO:0002242; GO:0002752; GO:0002768; GO:0005886; GO:0009626; GO:0009986; GO:0038187; GO:0140426

Evidence at protein level

5

SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27471302}; Single-pass membrane protein {ECO:0000255, ECO:0000305|PubMed:27471302}. Cell surface {ECO:0000305|PubMed:27471302}.

SIGNAL 1..20; /evidence="ECO:0000255"

TRANSMEM 1059..1079; /note="Helical"; /evidence="ECO:0000255"

PF00560;PF13855;

IPR001611;IPR003591;IPR032675;IPR051502;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), lamiids (clade), Solanales (order), Solanaceae (family), Solanoideae (subfamily), Solaneae (tribe), Solanum (genus), Solanum subgen. Lycopersicon (subgenus)

Solyc08g016270

false

455

A0A3Q7HRZ6

MTEYSLPTMNLWNNSTSDDNVSMMEAFMSSDLSFWATNNSTSAAVVGVNSNLPHASSNTPSVFAPSSSTSASTLSAAATVDASKSMPFFNQETLQQRLQALIDGARETWTYAIFWQSSVVDFSSPSVLGWGDGYYKGEEDKAKRKLSVSSPAYIAEQEHRKKVLRELNSLISGAPPGTDDAVDEEVTDTEWFFLISMTQSFVNGSGLPGQALYSSSPIWVAGTEKLAASHCERVRQAQGFGLQTIVCIPSANGVVELGSTELIVQSSDLMNKVRVLFNFSNDLGSGSWAVQPESDPSALWLTDPSSSGMEVRESLNTVQTNSVPSSNSNKQIAYGNENNHPSGNGQSCYNQQQQKNPPQQQTQGFFTRELNFSEFGFDGSSNRNGNSSVSCKPESGEILNFGDSTKKSASSANVNLFTGQSQFGAGEENNNKNKKRSATSRGSNEEGMLSFVSGTVLPSSGMKSGGGGGEDSEHSDLEASVVKEADSSRVVEPEKRPRKRGRKPANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELKSKLQNTESDKEDLKSQIEDLKKESRRPGPPPPPNQDLKMSSHTGGKIVDVDIDVKIIGWDAMIRIQCNKKNHPAARLMAALMELDLDVHHASVSVVNDLMIQQATVKMGSRHYTEEQLRVALTSKIAETH

Transcription factor MYC2 (LeMYC2) (SlMYC2) (Basic helix-loop-helix protein 147) (Transcription factor bHLH147) (bHLH transcription factor bHLH147)

Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

4,081

689

75,041

Activator;Developmental protein;DNA-binding;Growth regulation;Jasmonic acid signaling pathway;Nucleus;Plant defense;Reference proteome;Stress response;Transcription;Transcription regulation

GO:0000976; GO:0003700; GO:0005634; GO:0006355; GO:0006952; GO:0043565; GO:0045893; GO:0046983

Evidence at protein level

5

SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.

null

PF14215;PF22754;PF00010;

IPR045084;IPR054502;IPR011598;IPR036638;IPR025610;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), lamiids (clade), Solanales (order), Solanaceae (family), Solanoideae (subfamily), Solaneae (tribe), Solanum (genus), Solanum subgen. Lycopersicon (subgenus)

MYC2 BHLH147 JAMYC2 Solyc08g076930

false

456

A0A3Q7HYF0

MALSMDNIVISNEEEIYMMKAMHIPCGLYLNMVLRAAIELDLFEIIAKSTTQKLSSYEIASQIPTKNPNASSLVLERILRFLASQSFLTCNITKNDDGNVHTSYNLTPLSQSLILDKDGTSIAPFLLLATDPVAVNSWFHFKDAILEGEIPFNKAHGVHAFEYHGKDSRFNGVFNKAMQNVTCIDMKRVLECYNGFEGVKEIIDVGGGLGISLASIISKYPNIKGINFDLPHVIKDAPTYEGIEHVGGDMFKSVPQRELILLKAILHDWDDECCVKILKNCWRALPKDGKVVVIEQMQPEYPEINLISKNSFSVDMLMMTMLDGGKERTKQQFEDLAKQAGFTVFKIVARAYYCWVIELYK

Myricetin 3-O-methyltransferase 3 (SlMOMT3) (EC 2.1.1.-) (3',4',5'-trimethyl myricetin 3-O-methyltransferase) (EC 2.1.1.-) (3',5'-dimethyl myricetin 3-O-methyltransferase) (Syringetin 3-O-methyltransferase) (EC 2.1.1.-) (3'-methyl myricetin 3-O-methyltransferase) (Laricitrin 3-O-methyltransferase) (EC 2.1.1.-) (3'-methyl quercetin 3-O-methyltransferase) (Isorhamnetin 3-O-methyltransferase) (EC 2.1.1.-) (4'-methyl kaempferol 3-O-methyltransferase) (Kaempferide 3-O-methyltransferase) (EC 2.1.1.-) (7-methyl quercetin 3-O-methyltransferase) (Rhamnetin 3-O-methyltransferase) (EC 2.1.1.-) (Kaempferol 3-O-methyltransferase) (EC 2.1.1.-) (Quercetin 3-O-methyltransferase) (EC 2.1.1.76)

Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

4,081

361

40,649

Methyltransferase;Reference proteome;S-adenosyl-L-methionine;Transferase

GO:0008171; GO:0008757; GO:0009058; GO:0009813; GO:0030755; GO:0032259; GO:0046983; GO:0102440; GO:0102449

Evidence at protein level

5

null

PF08100;PF00891;

IPR016461;IPR001077;IPR012967;IPR029063;IPR036388;IPR036390;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), lamiids (clade), Solanales (order), Solanaceae (family), Solanoideae (subfamily), Solaneae (tribe), Solanum (genus), Solanum subgen. Lycopersicon (subgenus)

MOMT3 Solyc06g083445

false

457

A0A3Q7I7R4

MATEAPVEATEIPSVAAAETVEKQPHKLERKWTFWFDNQSKPKQGVAWGSSLRKAYTFETVEEFWSLYDQIFKPSKVTVNADFHLFKAGIEPKWEDPECANGGKWTATSSRKANLETMWLETLMALVGEQFDESEDICGVVASVRRSQDKLSLWTKTATNEAAQMGIGRKWKEIIDAEKISYSFHDDSKRERSAKSRYTV

Eukaryotic translation initiation factor isoform 4E (SleIF(iso)4E) (eIF(iso)-4E) (eIF-(iso)4F 25 kDa subunit) (eIF-(iso)4F p28 subunit) (mRNA cap-binding protein)

Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

4,081

200

22,823

Cytoplasm;Disulfide bond;Initiation factor;Nucleus;Protein biosynthesis;Reference proteome;RNA-binding;Translation regulation

GO:0000340; GO:0003743; GO:0005634; GO:0006413; GO:0006417; GO:0009615; GO:0016281; GO:0050687

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A0A445AGS0}. Nucleus {ECO:0000250|UniProtKB:A0A445AGS0}.

null

PF01652;

IPR023398;IPR001040;IPR019770;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), lamiids (clade), Solanales (order), Solanaceae (family), Solanoideae (subfamily), Solaneae (tribe), Solanum (genus), Solanum subgen. Lycopersicon (subgenus)

eIFiso4E

false

458

A0A3Q8GL18

MASTANPMQVMKKKLEGKVVIVTGGASGIGQTAARVFAQHGARAVVIADIQSEVGKSVAKSIGDPCCYVQCDVSDEEEVKSMIEWTASAYGGLDMMFSNVGIMSKSAQTVMDLDLLEFDKVMRVNARGMAACLKHAARKMVELGTRGTIICTTTPLSSRGGQSMTDYAMSKHAVMGLVRSASIQLGAHGIRVNCVTPSVVLTPLAQRMGLATPDDFHTHFGNFTSLKGVYLTPEQVAEAVVYLASDDAAFITGHDLVLDGGLLCLPFFAPS

(+)-cis,trans-nepetalactol synthase NEPS1 (EC 5.5.1.34) (Nepetalactol-related short-chain dehydrogenase) (Nepetalactol dehydrogenase) (EC 1.1.1.419) (Nepetalactol-related short-chain reductase 1) (Nepetalactol-related SDR1) (NmNEPS1)

Nepeta racemosa (Catmint) (Raceme catnip)

54,731

271

28,683

Isomerase;NAD;Oxidoreductase

GO:0016491; GO:0016853

Evidence at protein level

5

null

PF13561;

IPR036291;IPR002347;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), lamiids (clade), Lamiales (order), Lamiaceae (family), Nepetoideae (subfamily), Mentheae (tribe), Nepetinae (subtribe), Nepeta (genus)

NEPS1

false

459

A0A3S5XFG0

MHSVRTSTTSTSSMVSSTMHPFDAFNAPQPYQQHHPPRWNIHNPHFSQTNGHSIQKTPSMIKLHSSEGTVPTTNGADTLHQRNMEEKIISAPLHYITGLPGKDIRGKLISAFNEWFRIPDEQLEIIKRVVGLLHVASLLIDDIEDSSKLRRGFPVAHSIFGIPQTINSANYAYFQAQSEVLKLRNCNAAFTIFTEELLRLHRGQGMDLYWRDSLTCPTEEEYLDMVANKTGGLFRLAIKLIQLESDVEDDCVPLVDLLGIIFQIRDDYQNLQNEQYAKNKGFAEDITEGKFSYPIVHSIRSGAANCSSGSSELMNILRQKTDDEAVKRYTICILEKTGSFEYTRRKLTELMAAARAMLAEFGSAEAAGLGGILDFLELKE

Geranylgeranyl pyrophosphate synthase cle6 (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (15-deoxyoxalicine B biosynthesis cluster protein C) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Diterpenoid pyrone biosynthesis cluster protein D) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)

Aspergillus versicolor

46,472

380

42,725

Magnesium;Metal-binding;Transferase

GO:0004659; GO:0008299; GO:0043386; GO:0046165; GO:0046872

Evidence at protein level

5

null

PF00348;

IPR008949;IPR000092;IPR033749;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Ascomycota (phylum), saccharomyceta (clade), Pezizomycotina (subphylum), leotiomyceta (clade), Eurotiomycetes (class), Eurotiomycetidae (subclass), Eurotiales (order), Aspergillaceae (family), Aspergillus (genus), Aspergillus subgen. Nidulantes (subgenus)

cle6

false

460

A0A3S5YBC7

MRKTVVAFAAAIAACSAVLSSTTTSAAPPATPITTLQADGTHLVDGYGRTVLLHGVNNVDKDAPYLPAGETLTPQDIDILVRHGFNTVRLGTSFDALMPQRGQIDEAYLDRLTGVVDALTARGMHVLLDNHQDGLSKAWGGNGFPEWAIESRPREWEPNPGFPLYYLMPSLNAGWDEVWGNTHGALDHLGTALGALAERVEGKPGVMGIELLNEPWPGSRFLSCFPNGCPDFDRTYQAAMQKLTDAVRAQNPTIPVYWEPNVTWNQMMPSNLFAPPVTPALTTADVVFAPHDYCIPSQLAIYLGLPQALRGLCVPQQDLTWSNIDAITERANVPTVITEFGDGDPTVLKNTLARADERFIGWQYWHFGAGNATDPFLGEVGRQLVRTYPQATAGEPGRMIFDADNGDFAYRFTPRAATRPTEIFVSDLHYPDGYAVQVDGGQVTSAPGARIVTVVADGSGPVTVKINRPGSAGAEVPDGPIETSSSGSSGSS

Endoglycoceramidase I (EGCase I) (EC 3.2.1.123)

Rhodococcus hoagii (strain 103S) (Rhodococcus equi)

685,727

492

52,830

3D-structure;Disulfide bond;Glycosidase;Hydrolase;Lipid metabolism;Lipoprotein;Membrane;Palmitate;Secreted;Signal;Sphingolipid metabolism

GO:0000272; GO:0005576; GO:0006683; GO:0016020; GO:0047876

Evidence at protein level

5

SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28179425}. Membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.

SIGNAL 1..14; /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"

null

PF00150;PF18564;

IPR041036;IPR001547;IPR013780;IPR017853;IPR052066;

5CCU;5J14;5J7Z;

cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Mycobacteriales (order), Nocardiaceae (family), Prescottella (genus), Rhodococcus hoagii (species)

REQ_38260

false

461

A0A3S7WQS5

MDDRSLKLAEDFVSARYIEAGRESLRATARIMRSILAQRCCPDEGLTDAAIELILRQLSLMDTNNLAHHVGGGEREGRVVSALVRMRHFHLTHGIGRSGDLFSEQPKAAGSSLLYKITNVLMLDLIRQAGAPSTAAAVVVPMATGMTLALVLRCVAKTHMKELMKEAEAVQLQRTVTKDSTSATSAAPVQEPPMSEADRDRHDRTSLPVPATPRYVIWPRIDQKTALKCIDAAGLVPVPVQLRPAVPLARSAAPCVSTNRDSLDRGQDSIGSPSTPTSSSSLFLECHVDDVAAAVNAVGGPSQVVCVLSTTSCFAPRLPDNTVAIAQYCKKAGIPYVVNNAYGVQSRRIMTRLDAAQRLGRVDFVVQSGDKNFLVPVGGSIICSGDKERCKAVAALYAGRASMSPIVDLFITALSLGRRGMQTLWSDRYKCRARLIRQLRVFARERREVLLVDDSDDDKADEDTVGGSQRTSNAVVPRNDISVAVTMRAYGLPAAEASSSGAQLGSEQAGRVTNWAAARALGAQLFRSAVTGPRVITPAPSTPTTIAGCTFRNYGMHQDREPPCPLLVIACGIGMSESEVDALMARLRDLWPVPA

O-phosphoseryl-tRNA(Sec) selenium transferase (EC 2.9.1.2) (Selenocysteine synthase) (Selenocysteinyl-tRNA(Sec) synthase) (Sep-tRNA:Sec-tRNA synthase)

Leishmania donovani

5,661

595

63,923

Cytoplasm;Protein biosynthesis;Pyridoxal phosphate;RNA-binding;Selenium;Transferase;tRNA-binding

GO:0000049; GO:0001514; GO:0001717; GO:0005737; GO:0016785; GO:0098621

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PIRNR:PIRNR017689, ECO:0000269|PubMed:26586914}.

null

PF05889;

IPR015424;IPR015421;IPR019872;IPR008829;

null

cellular organisms (no rank), Eukaryota (domain), Discoba (clade), Euglenozoa (phylum), Kinetoplastea (class), Metakinetoplastina (subclass), Trypanosomatida (order), Trypanosomatidae (family), Leishmaniinae (subfamily), Leishmania (genus), Leishmania (subgenus), Leishmania donovani species complex (no rank)

SepSecS LdCL_090015500

false

462

A0A411MR89

MSHVPPHVPFELSGAELRDAIVQYATNPIYHDNLDWLNHDNPYRRQLRPQVLPHLDYDKVPGRENILNYASLAVQRLLTSVYEADLVFFPKSGLKGKEEDFRAFYSPANRALGERIRPALERYAFGFLDDEVETSGTWTAQSLDAYLDSLDTAGGAEQSPVEKAILGSADRERAARMWLVQFAPDFLSEASPMMRNVLGYYGPAQSEWFKVVIDEYGYGVHDTKHSTLFERTLESVGLESDLHRYWQYYLNSSLLLNNYFHYLGKNHELFFRYVGALYYTESSLVDFCRRADHLLREVFGDTVDTTYFTEHIHIDQHHGRMAREKIIKPLVEAHGDGIIPEIVRGIEEYRVLLEIGDFDFSEQIAWMDAQPELKKLHDPVFEGLKQGKVDAPVAHLVEPRGELSNTHCHDGDELCHIVSGTMRFESGLGSSLTLQAGEGVVIKRNRLHGANIESDECVYEIHSVGDYRKCL

Nitrosourea synthase (EC 1.14.13.250) (Multi-domain metalloenzyme SznF)

Streptomyces achromogenes subsp. streptozoticus

285,532

471

53,802

3D-structure;Antibiotic biosynthesis;Iron;Metal-binding;Monooxygenase;Oxidoreductase

GO:0004497; GO:0017000; GO:0046872

Evidence at protein level

5

null

PF07883;PF14518;

IPR013096;IPR016084;IPR014710;IPR011051;

6VZY;6XCV;8E8W;

cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Actinomycetota (phylum), Actinomycetes (class), Kitasatosporales (order), Streptomycetaceae (family), Streptomyces (genus), Streptomyces achromogenes (species)

sznF stzF

false

463

A0A445AGS0

MATETAGAVVESSSAATVPSPAPEAGSKHKLERKWTFWFDNQSKPKQGAAWGTSLREVYTFDTVEEFWCLYDQVFKPSKLPGNADFHLFKTGIEPKWEDPECAKGGKWTVTSNRKANLDNMWLETMMALIGEQFDDAEDICGVVASVRQRQDKLSLWTKTAANEAAQMGIGRKWKEIIDVTDKIIYNFHDDSRTRSSKSRYSV

Eukaryotic translation initiation factor isoform 4E (PeaeIF(iso)4E) (eIF(iso)-4E) (eIF-(iso)4F 25 kDa subunit) (eIF-(iso)4F p28 subunit) (mRNA cap-binding protein)

Arachis hypogaea (Peanut)

3,818

203

22,953

Cytoplasm;Disulfide bond;Host-virus interaction;Initiation factor;Nucleus;Plant defense;Protein biosynthesis;Reference proteome;RNA-binding;Translation regulation

GO:0000340; GO:0003743; GO:0005634; GO:0005737; GO:0006417; GO:0016281; GO:0051607

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28344571}. Nucleus {ECO:0000269|PubMed:28344571}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28344571}. Nucleus {ECO:0000269|PubMed:28344571}. Note=(Microbial infection) Binds to potyvirus viral genome-linked protein (VPg) in the nucleus and with viral helper component proteinase (HC-Pro) in the cytoplasm. {ECO:0000269|PubMed:28344571}.

null

PF01652;

IPR023398;IPR001040;IPR019770;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), rosids (clade), fabids (clade), Fabales (order), Fabaceae (family), Papilionoideae (subfamily), 50 kb inversion clade (clade), dalbergioids sensu lato (clade), Dalbergieae (tribe), Pterocarpus clade (clade), Arachis (genus)

eIF(iso)4E Ahy_B02g059482

false

464

A0A452E9Y6

MLVCLHLQVFLASVALFEVAASDTIAQAASTTTISDAVSKVKTQVNKAFLDSRTRLKTALSSEAPTTRQLSEYFKHAKGRTRTAIRNGQVWEESLKRLRRDTTLTNVTDPSLDLTALSWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLAVPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSSEHSKVQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPFFRAGFVCPTPPYQSLARDQINAVTSFLDASLVYGSEPSLASRLRNLSSPLGLMAVNQEAWDHGLAYPPFNNVKPSPCEFINTTAHVPCFQAGDSRASEQILLATVHTLLLREHNRLARELKRLNPHWDGEMLYQEARKILGAFIQIITFRDYLPIVLGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLLAKKSKLMNQNKMVTSELRNKLFQPTHKIHGFDLAAINLQRCRDHGMPGYNSWRGFCGLSQPKTLKGLQAVLKNKILAKKLLDLYKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFSRLICDNTHVTKVPLHAFQANNYPHDFVDCSAVDKLDLSPWASREN

Lactoperoxidase (LPO) (EC 1.11.1.7)

Capra hircus (Goat)

9,925

712

80,366

3D-structure;Antibiotic;Antimicrobial;Calcium;Cytoplasm;Direct protein sequencing;Disulfide bond;Glycoprotein;Heme;Hydrogen peroxide;Iron;Metal-binding;Nitration;Oxidoreductase;Peroxidase;Phosphoprotein;Reference proteome;Secreted;Signal

GO:0001580; GO:0004601; GO:0005509; GO:0005615; GO:0005737; GO:0006979; GO:0016323; GO:0019731; GO:0019732; GO:0020037; GO:0036393; GO:0042744; GO:0046265; GO:0140825

Evidence at protein level

5

SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18191143, ECO:0000269|PubMed:27398304, ECO:0000269|PubMed:30296068}. Cytoplasm {ECO:0000250|UniProtKB:Q5SW46}.

SIGNAL 1..21; /evidence="ECO:0000255"

null

PF03098;

IPR019791;IPR010255;IPR037120;

2E9E;2EFB;2EHA;2OJV;2R5L;3N8F;3NAK;3NIU;3QF1;3R55;3RKE;3SXV;4MSF;4OEK;4QJQ;5FF1;5HPW;6LF7;8ING;

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Mammalia (class), Theria (clade), Eutheria (clade), Boreoeutheria (clade), Laurasiatheria (superorder), Artiodactyla (order), Ruminantia (suborder), Pecora (infraorder), Bovidae (family), Caprinae (subfamily), Capra (genus)

LPO

false

465

A0A452G813

MTDSPFLELWQSRTVAIRERLGIGDQPNDSYCYNSAKNSTVLQGVTFGGIPTVLFIDVSCFLFLIVVFSIIRRKFWDYGRIALVSEGNSESRFRRLSSSSSGQQDFESELGCCSWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVVSCLSLCIILPVNLSGDLLDKDPYSFGRTTIANLQTDNNLLWLHTIFAILYLILTVVFMRHHTQSIKYKEESLVRRTLFVTGLPKDAKKETVESHFRDAYPTCEVVEVQLCYNVAKLIYLCKERKKTEKSLTYYTNLQVKTGQRTFINPKPCGQFCCCEVRGCEWEDAISYYTRMKDRLMERITEEECRVQDQPLGMAFVTFQEKSMATYILKDFNACKCQGLQCKGEPQPSSHSRELGISRWSVTFAAYPEDICWKNLSIQGFRWWFQWLGINFILFVGLFFLTTPSIILSTMDKFNVTKPIHALNDPIISQFFPTLLLWSFSALLPTIVCYSTLLESHWTKSGENRIMMTKVYIFLIFMVLILPSLGLTSLDFFFRWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMVMAKTAADRRNVKQHQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNLYFAYLPAKLEKRIHFAAVNQALAAPILCLFWLYFFSFLRLGLKAPLTLFTFLVLLLTILVCLAYTCFGCFRHLSPLNYKTEESANDKGNEAGAHVPPPFTPYVPRILNSSSSEKTALSPQQQTYGAINNISGTVAGQGLAQSPEDSVAAADQED

Mechanosensitive cation channel TMEM63A (Transmembrane protein 63A)

Capra hircus (Goat)

9,925

803

91,821

Calcium;Cell membrane;Endosome;Ion channel;Ion transport;Lysosome;Membrane;Phosphoprotein;Reference proteome;Transmembrane;Transmembrane helix;Transport

GO:0001817; GO:0003676; GO:0005227; GO:0005765; GO:0005886; GO:0007040; GO:0031901; GO:0032944; GO:0045428; GO:0050764; GO:0160069; GO:1990760

Evidence at protein level

5

SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:O94886}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:O94886}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:O94886}; Multi-pass membrane protein {ECO:0000255}.

null

TRANSMEM 52..74; /note="Helical; Name=TM0"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 134..166; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 191..216; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 416..443; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 462..489; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 495..531; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 554..585; /note="Helical; Name=TM6"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 606..623; /note="Helical; Name=TM7"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 628..650; /note="Helical; Name=TM8"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 661..688; /note="Helical; Name=TM9"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 694..708; /note="Helical; Name=TM10"; /evidence="ECO:0000250|UniProtKB:O94886"

PF14703;PF02714;PF13967;

IPR045122;IPR003864;IPR027815;IPR032880;IPR012677;IPR035979;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Mammalia (class), Theria (clade), Eutheria (clade), Boreoeutheria (clade), Laurasiatheria (superorder), Artiodactyla (order), Ruminantia (suborder), Pecora (infraorder), Bovidae (family), Caprinae (subfamily), Capra (genus)

TMEM63A

false

466

A0A455R4Z0

MPQLAGKLILAGLIPLGAWVLHGFASCNGLIQMFEDFGKQTVLSDGVTDYTGAFTGLEGLDRLLRTLLNFFWPVANGHDWALSLHAFMFAGQGVPLLVLNMLEGARPGNKSLVVSYVTVFGILYMVVGLAIMAPLYLFLHLLTSRTATAPSKAKVAVDPNTAKAVGFGVFVGYVLPTIFMSLPHPSLLSTDTKVLSVVFWQAVPLWASVCAYFASTALGQSATSRSSSNLPSALGAVYAASLIIATATHVATFAISANLSDTWSGIFTFLIPPNPFNTDMRISSFLEGATWFLQWDYTMMSLAYMVWAIGIRHGVEVPRSSHHFETLGKIALRSMAKLLVMGPIGAALSLVWERDQLLWQLDSESGEKGEKNRSRRMSRKWMFS

Terpene cyclase ascI (EC 5.4.99.-) (Ascofuranone/ascochlorin biosynthesis clusters protein I)

Acremonium egyptiacum (Oospora egyptiaca)

749,675

384

41,823

Glycoprotein;Isomerase;Membrane;Signal;Transmembrane;Transmembrane helix

GO:0016020; GO:0016114; GO:0016853

Evidence at protein level

5

SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.

SIGNAL 1..25; /evidence="ECO:0000255"

TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 119..139; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 194..214; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 291..311; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 330..350; /note="Helical"; /evidence="ECO:0000255"

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Ascomycota (phylum), saccharomyceta (clade), Pezizomycotina (subphylum), leotiomyceta (clade), sordariomyceta (clade), Sordariomycetes (class), Hypocreomycetidae (subclass), Hypocreales (order), Hypocreales incertae sedis (no rank), Acremonium (genus)

ascI

false

467

A0A481NV25

MKDMDIKAVFIGDKAENGPVYKMLLNKMVDEHLGWRENYIPSDMPAISEGDKLTPDYLATRDHMIEVLDEVSQRLRAGSIPWHSAGRYWGQMNAETLMPALLAYNYAMLWNPNNVALESSMATSQMEAEVGQDFASLFNMADGWGHIAADGSIANLEGLWYARCIKSIPLAVKEVLPEKVKNMSEWALLNLSVEEILEMTESFTDEEMDEVKAASSRSGKNIQKLGKWLVPQTKHYSWMKALDICGVGLDQMVAIPVQEDYRMDINALEKTIRELADQKIPILGVVAVVGTTEEGQVDSVDKIIQLREKLKDEGIYFYLHVDAAYGGYARSLFLNEAGEFVPYASLAEFFEEHHVFHHYVTIDKEVYEGFRAISEADSVTIDPHKMGYVPYAAGGIVIKHKNMRNIISYFAPYVFEKSVKAPDMLGAYILEGSKAGATAAAVWTAHRVLPLNVTGYGQLIGASIEAAQRFREFLEQLHFTVKGKTIEVYPLNHPDFNMVNWVFKVQDCTDLNAINELNEKMFDRSSYMDGDVYGERFITSHTTFTQEDYGDSPIRFIERMGLSKEEWQKEQQITLLRAAIMTPYLNDDRIFNFYTKEIAKAMEKKLNEIIK

L-tyrosine decarboxylase (TDC) (EC 4.1.1.25) (Levodopa decarboxylase) (L-dopa decarboxylase) (EC 4.1.1.-)

Enterococcus faecium (Streptococcus faecium)

1,352

611

69,341

Coiled coil;Decarboxylase;Lyase;Pyridoxal phosphate

GO:0004837; GO:0030170; GO:0036468; GO:1903184

Evidence at protein level

5

null

PF00282;PF21391;

IPR050477;IPR002129;IPR015424;IPR015421;IPR021115;IPR049373;IPR022397;

null

cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Bacillota (phylum), Bacilli (class), Lactobacillales (order), Enterococcaceae (family), Enterococcus (genus)

tdc mfnA_1

false

468

A0A482A9N4

MPSTKVAALSAVLALASTVAGHGYVQNIVIDGESYSGYIVTQFPYESNPPAVIGWATTATDLGYVDPTEYTNADIICHKNATPGALSAPVAAGGTVELQWTTWPDSHHGPVISYLANCNGNCSTVDKTKLDFVKIDASGLIDDTTVPGTWASDQLIAANNSWTVTIPETIAPGNYVLRHEIIALHSAENTDGAQNYPQCINLEITGSGTASPTGTPGEELYTPTDPGILVNIYQSLSTYVIPGPTLWSGAANNAVASATAAASATATPTTLVTSVASATDSPSTVAPASSTTATSVLTSVVPSVTSFVPVVTVTDVVTVTTVITTTVF

AA9 family lytic polysaccharide monooxygenase A (LPMO9A) (EC 1.14.99.56) (AA9 family lytic polysaccharide monooxygenase 1) (LPMO1) (Cellulase LPMO9A) (Endo-beta-1,4-glucanase LPMO9A) (Endoglucanase LPMO9A) (Glycosyl hydrolase 61 family protein LPMO9A)

Talaromyces verruculosus (Penicillium verruculosum)

198,730

328

33,652

3D-structure;Carbohydrate metabolism;Cellulose degradation;Direct protein sequencing;Disulfide bond;Glycoprotein;Methylation;Monooxygenase;Oxidoreductase;Polysaccharide degradation;Secreted;Signal

GO:0004497; GO:0005576; GO:0030245

Evidence at protein level

5

SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30847851}.

SIGNAL 1..21; /evidence="ECO:0000269|PubMed:31672609"

null

PF03443;

IPR049892;IPR005103;

7A8V;

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Ascomycota (phylum), saccharomyceta (clade), Pezizomycotina (subphylum), leotiomyceta (clade), Eurotiomycetes (class), Eurotiomycetidae (subclass), Eurotiales (order), Trichocomaceae (family), Talaromyces (genus), Talaromyces sect. Talaromyces (section)

lpmo1 LPMO9A

false

469

A0A482D308

MAKNTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKHLKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFRQLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELFKNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYTGFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLLLSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKIGEKSAWMLNLSIDVPKIDKGVDPSIIGGIDVGVKSPLVCAINNAFSRYSISDNDLFHFNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERWACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIEFKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKCNFKENADYNAALNISNPKLKSTKEEP

CRISPR-associated endodeoxyribonuclease Cas12f1 (Un1Cas12f1) (EC 3.1.-.-) (CRISPR-associated endodeoxyribonuclease Cas14a1)

Uncultured archaeon

115,547

529

61,517

3D-structure;Antiviral defense;DNA-binding;Endonuclease;Hydrolase;Metal-binding;Nuclease;RNA-binding;Zinc

GO:0003677; GO:0003723; GO:0004519; GO:0046872; GO:0051607

Evidence at protein level

5

null

PF07282;

IPR010095;

7C7L;

cellular organisms (no rank), Archaea (domain), environmental samples (no rank)

cas12f cas14a1

false

470

A0A482N9V7

MAANDSNNQTKPQLPEEPVAIVGSSCRFPGSSNSPSKLWDLLRQPRDVLKEFDPDRLNLKRFYHPDGDTHGSTDVTNKSYLLEEDSRLFDASFFTINPAEAAGMDPQQRILLETVYEAFESAGMTLEQLRGSLTAVHVGTMTNDYAGIQLRDLETIAKYNATGTANSIVSNRISYVFDLKGPSETIDTACSSSLVALHHAARGLLNGDCETAVVAGVNLIYDAASYIAESKLHMLSPDSQSRMWDKSANGYARGEGAAALLLKPLSRALRDGDHIEGVIRATGVNSDGQSPGITMPFAPTQAALIRQTYRRAGLDPVKDRPQYFECHGTGTPAGDPVEARAISEAFEPSADNPIYVGSIKTIIGHLEGCAGLAGVMKVILALKNRTIPPNMLFNELNPAIAPFYGPLQIPKKAMPWPELPENTPIRASVNSFGFGGTNAHVIIESFESSTPSSDSEKCEEGALGPLLFSAGSGASLLHTVQAYVQYLDQNPSVDLRDLSWLLQTRRSTHRVRTHFSGTSSDAILESMIKFVNNNEKTPSTEVGHQPKLINPKEVPGILGVFTGQGAQWPQMGKELIGKSPIFRRTLEDCDATLQALPSSDIPKWSLVKELMANASSSRVAEAAISQPLCTAVQLGLVNMLKASGLNFDAVVGHSSGEIAATYASGIINLQAAIQIAYYRGFHAKLAKGEKGQQGGMLAAGLTLDKAKQLCLREEFVGRLQVAASNAPQTVTLSGDLDAIEEVKKYLDEENVFARQLKVDTAYHSHHMKPCAEPYLKSLLACDIEVRKPTPGQCIWNSSVRGDTGLLKGDLSSLKGPYWVANMVQTVLFSQAVESSIWHGGPWDLAIEVGPHPALKGPTEQTLKAVYGVVPLYTGVLKRGASDVEAFSTAIGVTWSQLGPSFVDFAGYRKTFYESEPPTPKVIKDLPGYSWDHDKVYWRESRISKRYRTGRDQTHELLGRRTPDDNEFELRWRNVLKLSEMPWLRGHEVLEEVLLPGAAYVSIAVEASKHIATSKGKSIELLEVEDVDIQRPVVVPDNKEGVETLFTARLLPGSSSDKVLKALFSYYICNDQSTGTMVHTCSGRLSVHLGEAKEDVLPQRDPVPQNLVNINTDRAYGMFKDIGLNYTGVFRSIKESSRTLQYSAATGIWPEGSLSDKYLVHPAMLDVAFQTLFIARAHPASRLITSALLPSHIERIQVSPSVPILHARENSDEIKADFDCWVVHQTASSLTGDLNIYDKVSGKTFLQVEGLTTKMVGEQDASGDRPVFTKTVWGSDGSLGLDEPERDPVGDAEGLSLAEAAERMALFYMKRVVKEISPEERTKFQWYHQRMFEAFEQHLVNVGSGSHPMLKSEWLSDDSSIMDGLDRIHPTSIDLKLLRACGENMPDVVREKTQLLEVMSKDDMLNRFYMDNCAARINNDIAKVVKQISFKFPRANILEIGAGTGGTTWSILKDINDAYDSYTFTDISSGFFPKAAEKFSDFAHKMIFKTLDVEKQPSEQGFAENSYDVIVAANVLHATRSLETTLRNARSLLRPGGYLILMEITNPESLRTTFIFGGFSGWWLSEEPHRKLGPVVTAMDWDTVLNDTGYSGADMVVHDLAEESKHLTSLIVSQAVDDDFLRLREPLSNLADMSAPTESILVIGGKKLLTSKMVNEINKLLPKSWKRHISSAGSIDDIDINELKPGTEVISLQELDDPLFSTPMTAERMSTIQNLMMSAKTLLWVTTAGKSHAPRASMFHGIARIVPSELQHLQIQVLGLEAGSTPAIATRHCVEAFLRLRGTSDTTREMLWAIEPEVEIMADGQVLIPRVVPDETLNQTYNASRRVVTKTVDATDLAVEAVAGPTKMMLQTAELQAGERKTRIQVKYALHLPAMDGKGIYVVYGQRQDDTSSFVLAVSKSNSSIVDVDSKHAVSVSDNCEPATLNVLATYLIARAIATLSKQAGSVLLSEPEESLAAIVATETAKQGTQAYFLSSKKVSPVEWIKVHANASKRAIQKAVPHDVQLLIDCSGIEASGNAVMASMPLHCVERQLDAHLLFDALESTESKPESLLEEAYQYATQLITQEQVQSECEVFPASDLPLTNMLSLVHKKYVTDWQQRDSLVVSVPPLDLEGIFKADKTYLMVGAAGGLGLSICEWMIRNGAKNLIITSRKPQVDQNMIEEASRVGATVKVMAMDVSSKESVAEVVQQAQEIMPPIAGVCNAAMVLSDKMFLDMDVDQLNGTLAAKVYGTEHLDAVFADAPLDFFIVLSSTATTIGNIGQANYHVANLFMTSLVAQRRARGLAGSVIHIGYVADVGYVTRQDRERQLEQHFRNVRLMALSETDVHHAFAEAVRGGRPGNTVGSPDIIMGLEPASVPLEPERQTLWLSNPCFGHLVPSTLQNDSSQTGGTGNGSSVRRQVEEAQTEDEAVDAVLDGFCAKLEAILQLREGSVKENVQRAVIDLGIDSLVAVEIRTWFLKELGAEVPVVKILGGDTVLQICTTAAKKVMANAMKKKEEDAVAEEGGREAASKKEPAPAASAPTPAPVAPSLLDVPARAFEPDSATISEVGDDSAFSNKGSSSSATGASSPKELSDSESVPDTSKDQSHVRPETVRDERMSPAQARIWFLTKHLDDPSAYNMVFHYRVKGPLKTVRLRHALQVATGHHESLRTLFYSRLEDGQPMQGVMPASAYELKHVPGADEADLKKELALLKAREWDLENGRTFSVSVLSRAADEHDVVFGYHHIIMDVVGWYFFVRDLDRAYRMQPFDKKISGSYVDYSVMQLSQKNTAAASDDLAFWQKEFSTVPDPIPLLPIAAVSARPTDSGRKVSHHEYLELDPAQNLAVKETCEKLRISPFHFHVAVLRALIGGYTNIDDMCIGVVDANRGDERFAQTVGCFVNMLPVRVEAPSDATFADIARSASRKALMAFAHSSAPLDMILDAVKAPRSSETTPLFQVAVNYRTGGVWDLPMGDCQMKLSLTDGKDAENPFDISLGIAETGKGCVIEMHCQKTLYSSDATRTLLNTYLRLVDTFCKNTHVKLKDCVIHDQAKVSEALQIGKGPTTDFGWPSTLSHRVLETCLKSPKNAAIQFKGELLSYEQLASRIHLVAAAIVRAGASKGSRVAVLCEPSADAIISMLATLHIGGVYIPMDVSLPTARHAAMMNGGQPTLLLSHAATKHRVEDLVNETGSTISVLQVDTISSVEEKETVSCAAEPHNNAVLLFTSGSTGTPKGIMLSQANFVNHLALKTDRLQLGQENVLQQSSMGFDMSLIQMFCALANGGCLVIAPSEMRRDPVELTNLVHNSQISLTIATPSEYLAWLRYGTASLKDHTIWRHACMGGEPVSRQLKTEFWRLDLANLQLTNCYGPTEITAAATFETIRLDDQDDDNDRAQHAVGKALPNYSVRILDTAGRPQPVDHIGEICIGGASVALGYLGLPEQTKAKFTVDPVSGERLYLTGDKGKLLSDGTLLCLGRLDGDTQIKHRGLRIELQEVESALIQTANGLFSSAVVSARGSILVAHATISQSQAEPSESDLAKILSRLKLPQYFIPATIGILPTMPTTANGKLDRKAIASLPLPQKVTGEEGPQEKMNIREGELRLLWERVLPDTATTTPLGPSSDFFLCGGNSMLLMKLQAAIKESIGIEISTRVLYQASTLREMALCVDEQREEQADALEQHFDWQAETSLPKWLLDQIEDLPKTTKQPPKPNGIDILMTGATSFIGGRLLRSLVRSPSVRKVHCVAVLADEQDQLYQDEKVKCYTGSLLSSTLGLNNGERDQLARNVDVVIHAGSSGHCLNTYGSLRTPNLVSLQFLASLALPRSIPLLLLSSNRVPLLSGNTALPPTSVAAFPPATDGREGYTATKWASEVFLEKLVGAVQKKAPRPWVASVHRPCVVVSEHAPNSDALNAILRYSASMKCVPHLESATGYLDFASVESIVDSMAESAIEMATGNVTDQPSIRFQHHSGGVKVPIGDFKVHMENVYGGNFEEVHLEEWMHRAAAAGLDPLITAYMEGIIEAGAPIVFPYLGETV

Hybrid PKS-NRPS synthetase iccA (PKS-NRPS iccA) (EC 2.3.1.-) (EC 6.3.2.-) (Ilicicolin H biosynthesis cluster protein A)

Talaromyces variabilis (Penicillium variabile)

28,576

4,015

438,112

Ligase;Methyltransferase;Multifunctional enzyme;Oxidoreductase;Phosphopantetheine;Phosphoprotein;Repeat;Transferase

GO:0004312; GO:0004315; GO:0006633; GO:0008168; GO:0016218; GO:0016491; GO:0016874; GO:0031177; GO:0032259; GO:0140781; GO:1904091

Evidence at protein level

5

null

PF00698;PF00501;PF00668;PF16197;PF00109;PF02801;PF08659;PF08242;PF07993;PF21089;PF00550;PF14765;

IPR010071;IPR001227;IPR036736;IPR014043;IPR016035;IPR045851;IPR020845;IPR000873;IPR042099;IPR023213;IPR001242;IPR013120;IPR018201;IPR014031;IPR014030;IPR016036;IPR013217;IPR036291;IPR032821;IPR020841;IPR042104;IPR020807;IPR049551;IPR049552;IPR013968;IPR049900;IPR050091;IPR020806;IPR009081;IPR006162;IPR029063;IPR016039;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Ascomycota (phylum), saccharomyceta (clade), Pezizomycotina (subphylum), leotiomyceta (clade), Eurotiomycetes (class), Eurotiomycetidae (subclass), Eurotiales (order), Trichocomaceae (family), Talaromyces (genus)

iccA

false

471

A0A494BA31

MKLPGQGDFESSDAHENAHSEEPDSGLGPGPGLNGPSGIDIGESQVSKDPLLFIQLNELLGWPQALEWRETGRWLLFEEKLDMGAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLDCQAQSLLELVEQVVSGESLSPELRGQLQALLLQRPQHHIQTMGIRPCRESNAFRKASRDEDAPLKHQNPLRQKLPAGAEAAAVLAGELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEMGRAAAVLLSDPQFQWSVRRASHLPDLLAALDAFLQEVTALPPGRWDRTARIPPPKYLPSQHKRFPSKLQEVTSLSRQSAALAEDKHHHGPHTPIPELQRTGRLFGGLIQDVRRKACWYTSDFLDALHPQCFSAVFYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAMGKMLNLIRAYPIQRPGSSAYGCFCQYPGTGGNTSEWTSAKLKDTEDILSVPGLVNASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKHIKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTFLGLATPKLLVPTEFKPTLSGRGWLVSPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHLFTAIQLACLGLLWVVKSTPAAIVFPLMLLGLVAIRKALEWVFSPQELLWLDELMPEEEETIPENRSEPEHLFSGNDSEDSELMYQPKAPEINISVN

Anion exchange protein 4 (AE 4) (Anion exchanger 4) (Solute carrier family 4 member 9)

Mus musculus (Mouse)

10,090

952

104,989

Cell membrane;Glycoprotein;Ion transport;Membrane;Reference proteome;Sodium;Sodium transport;Transmembrane;Transmembrane helix;Transport

GO:0008510; GO:0016020; GO:0016323; GO:0022853; GO:0035725; GO:0045177; GO:0046541; GO:0140892; GO:0140900

Evidence at protein level

5

SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12225984, ECO:0000269|PubMed:23610411, ECO:0000305|PubMed:34585968}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the basolateral membrane of the cortical collecting duct (CCD)and submandibular gland (SMG) duct. {ECO:0000269|PubMed:12225984, ECO:0000269|PubMed:23610411}.

null

TRANSMEM 385..405; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 501..521; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 593..613; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 634..654; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 681..701; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 727..747; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 784..804; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 807..827; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 870..890; /note="Helical"; /evidence="ECO:0000255"

PF07565;PF00955;

IPR013769;IPR011531;IPR003020;IPR003024;IPR016152;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Mammalia (class), Theria (clade), Eutheria (clade), Boreoeutheria (clade), Euarchontoglires (superorder), Glires (clade), Rodentia (order), Myomorpha (suborder), Muroidea (clade), Muridae (family), Murinae (subfamily), Mus (genus), Mus (subgenus)

Slc4a9 AE4

false

472

A0A498JQK2

MTSSEPASPEIEQQANSAPRRPRILLAASGSVAAIKFGNLCHSFSEWAEVKAVATRASLHFIDRASLPKDVILYTEEDEWSTWNKVGDSVLHIELRSWADILVIAPLSANTLGKIAGGLCDNLLTCIVRAWDYSKPFFVAPAMNTLMWKNPFTEQHIMSIDELGVSLIPPVTKRLACGDYGNGAMAEPSVIYSTVRLFFESRVQQSGNIVQQPV

Phosphopantothenoylcysteine decarboxylase HAL3 (PPCDC) (EC 4.1.1.36) (Halotolerance protein 3) (MdHAL3)

Malus domestica (Apple) (Pyrus malus)

3,750

214

23,535

Cell membrane;Coenzyme A biosynthesis;Cytoplasm;Decarboxylase;Flavoprotein;FMN;Growth regulation;Lyase;Membrane;Reference proteome;Stress response

GO:0004633; GO:0005737; GO:0005886; GO:0009651; GO:0010181; GO:0015937; GO:0071513; GO:1901002; GO:2000280

Evidence at protein level

5

SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32761275}. Cytoplasm {ECO:0000269|PubMed:32761275}.

null

PF02441;

IPR036551;IPR003382;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), rosids (clade), fabids (clade), Rosales (order), Rosaceae (family), Amygdaloideae (subfamily), Maleae (tribe), Malus (genus)

HAL3 DVH24_008624

false

473

A0A499UB99

MATNNIVVLGAGVSGLTTAWLLSKDPSNKITVAAKHMPGDYDIEYCSPWAGANYLPVGAENSRVGQWERATWPHLRDIAQNHPEAGIHFQDTVVYNRTKDQGSTTGQWFSELVKPNPWYGKVLPNFRELSKDELPPGIDNANRFTSVCINTAVYLPWLVGQCRKNGVVFKRAVFKHVAEAANAHHSGQKADLVVNCTGLSSRKLGGVQDNTLLPARGQIVVVRNDPGLMCSISGTDDGDDEVTYMMTRAAGGGTILGGTYQKHNWDSLPDPNLAVRIMKRCIELCPSLVAPGQGIEGLDIIRHGVGLRPVREDGPRIEKELIDGVWVVHNYGHGGYGYQTSFGCATTAVEVVREALQQQKQRRDKARL

D-amino-acid oxidase (DAAO) (DAMOX) (DAO) (EC 1.4.3.3) (ReDAO)

Talaromyces emersonii (Thermophilic fungus) (Rasamsonia emersonii)

68,825

368

40,294

3D-structure;Disulfide bond;FAD;Flavoprotein;Oxidoreductase;Peroxisome

GO:0003884; GO:0005782; GO:0019478; GO:0019740; GO:0046416; GO:0071949

Evidence at protein level

5

SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000250|UniProtKB:Q9HGY3}.

null

PF01266;

IPR006181;IPR023209;IPR006076;

7CT4;

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Ascomycota (phylum), saccharomyceta (clade), Pezizomycotina (subphylum), leotiomyceta (clade), Eurotiomycetes (class), Eurotiomycetidae (subclass), Eurotiales (order), Trichocomaceae (family), Rasamsonia (genus)

DAO1

false

474

A0A4P8DY91

MTTTELIPPTIQVDEEEEEACMFAMQLASASVLPMVLKSAIELDLLESIAKAGPGAYVSPSELAAKLPSSQPDTPVMLDRILRLLASYSVLKCKVQDLPQGGVERLYALAPVCKFLTKNSDGVSMAPLLLMNQDKILMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGKDPRFNKVFNLGMSNHSTITMKKILQTYNGFAGLKTVVDVGGGTGATLNMIISKYPNIKGINFDLPHVVEDAPSYPGVEHVGGDMFVSVPEGDAIFMKWICHDWSDAHCLSFLKNCYKALPQNGKVILAECILPEAPDSKLTTKNVIHIDVIMLAHNPGGKERTEKEFEALGKMAGFKSFNKVCCAHNTWIMEFLK

Esculetin O-methyltransferase (EC 2.1.1.-) (Bergaptol O-methyltransferase) (EC 2.1.1.69) (Isoscopoletin O-methyltransferase) (EC 2.1.1.-) (Scopoletin O-methyltransferase) (EC 2.1.1.-) (Xanthotoxol O-methyltransferase) (EC 2.1.1.70)

Kitagawia praeruptora (Peucedanum praeruptorum)

312,531

364

39,979

3D-structure;Methyltransferase;S-adenosyl-L-methionine;Transferase

GO:0008171; GO:0008757; GO:0009411; GO:0009805; GO:0016206; GO:0032259; GO:0042542; GO:0046983

Evidence at protein level

5

null

PF08100;PF00891;

IPR016461;IPR001077;IPR012967;IPR029063;IPR036388;IPR036390;

6IWT;

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), asterids (clade), campanulids (clade), Apiales (order), Apiineae (suborder), Apiaceae (family), Apioideae (subfamily), apioid superclade (clade), Selineae (tribe), Kitagawia (genus)

COMT-S

false

475

A0A4S8L4Q5

MESSTQTKPGSLIVVGTGIESIGQMTLQALSYIEAASKVFYCVIDPATEAFILTKNKNCVDLYQYYDNGKSRMDTYTQMAELMLKEVRNGLDVVGVFYGHPGVFVNPSHRALAIARSEGYQARMLPGVSAEDCLFADLCIDPSNPGCLTYEASDFLIRERPVNVHSHLILFQVGCVGIADFNFSGFDNSKFTILVDRLEQEYGPDHTVVHYIAAMMPHQDPVTDKFTIGQLREPEIAKRVGGVSTFYIPPKARKDINTDIIRLLEFLPAGKVPDKHTQIYPPNQWEPDVPTLPPYGQNEQAAITRLEAHAPPEEYQPLATSKAMTDVMTKLALDPKALAEYKADHRAFAQSVPDLTPQERAALELGDSWAIRCAMKNMPSSLLEAASQSVEEASMNGFPWVIVTGIVGVIGSVVSSA

Methyltransferase/ribosomally synthesized cyclic peptide dendrothelin A precursor dbihMA (Dendrothelin A biosynthesis cluster protein MA) [Cleaved into: N-methyltranferase dbiM (EC 2.1.1.-); Ribosomally synthesized cyclic peptide dendrothelin core peptide; Follower peptide]

Dendrothele bispora (strain CBS 962.96)

1,314,807

417

45,850

3D-structure;Methylation;Methyltransferase;Reference proteome;S-adenosyl-L-methionine;Transferase;Virulence

GO:0008168; GO:0032259

Evidence at protein level

5

null

PF00590;

IPR000878;IPR035996;IPR014777;

6MJF;6MJG;

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Basidiomycota (phylum), Agaricomycotina (subphylum), Agaricomycetes (class), Agaricomycetidae (subclass), Agaricales (order), Agaricales incertae sedis (no rank), Dendrothele (genus), Dendrothele bispora (species)

dbiMA dbophM K435DRAFT_765759

false

476

A0A4X1UM84

MPPQLSNGLNHSAKVVRGTLDSLPQAVRDFVESSAKLCQPDQIHICDGSEEENQQLLSHMEEEGVIKRLKKYDNCWLALTDPRDVARIESKTVIITQEQRDAVPIPRSGLSQLGRWMSPEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGSAVLDALGAGEFIKGLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHMLILGVTNPEGQKKYFAAAFPSACGKTNLAMMNPTLPGWKVECVGDDIAWMKFDQQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQSNTIFTNVAETSDGGVYWEGIDQPLAPGIKLTSWKGTEWDPKDGEPCAHPNSRFCTPASQCPIIDPAWEAPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKVIMHDPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKDGRFLWPGFGENCRVLAWMFDRVQGKGGARLTPIGYVPEEAALDLRGLEAIRVSELFQVSKEFWEEEADEIHKYLEEQVNADLPYEIQSEVLALKQRISQM

Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32) (Serine-protein kinase PCK1) (EC 2.7.11.-)

Sus scrofa (Pig)

9,823

622

68,884

Acetylation;Cytoplasm;Decarboxylase;Endoplasmic reticulum;Gluconeogenesis;GTP-binding;Kinase;Lyase;Manganese;Metal-binding;Nucleotide-binding;Phosphoprotein;Reference proteome;Transferase;Ubl conjugation

GO:0000287; GO:0004613; GO:0005525; GO:0005783; GO:0005829; GO:0006094; GO:0006107; GO:0009617; GO:0018105; GO:0030145; GO:0031406; GO:0032869; GO:0043382; GO:0045944; GO:0046166; GO:0046327; GO:0046889; GO:0046890; GO:0051365; GO:0071333; GO:0072350; GO:0106264

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P35558}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P35558}. Note=Phosphorylation at Ser-90 promotes translocation to the endoplasmic reticulum. {ECO:0000250|UniProtKB:P35558}.

null

PF00821;PF17297;

IPR018091;IPR013035;IPR008209;IPR035077;IPR035078;IPR008210;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Mammalia (class), Theria (clade), Eutheria (clade), Boreoeutheria (clade), Laurasiatheria (superorder), Artiodactyla (order), Suina (suborder), Suidae (family), Sus (genus)

PCK1 PEPCK1

false

477

A0A4Y1WBN6

MGLHFSVLASGSTGNMLYVGTDEKKLLVDAGLSGKATEALFKQAELNINDVSGILVTHEHSDHIKGLGVLARKYDLPVYANEKTWNAMEHLIGNIPTDQKFIFSVGDVKTFGDIEVESFGVSHDAAEPMFYAFHNNNRKLALITDTGYVSDRMKGVIKGANAFVFESNHDVEMLRMGRYPWSIKRRILSDVGHVCNEDAALAMADVITDETKHIYLAHLSLDNNMKELARMSVSQVLEEKGFGVGEAFEIHDTDPKMPTKIQYV

Exodeoxyribonuclease YycJ (EC 3.1.11.-)

Bacillus anthracis

1,392

264

29,293

Exonuclease;Hydrolase;Metal-binding;Nuclease;Reference proteome

GO:0004527; GO:0046872

Evidence at protein level

5

null

PF12706;

IPR001279;IPR036866;IPR052533;

null

cellular organisms (no rank), Bacteria (domain), Bacillati (kingdom), Bacillota (phylum), Bacilli (class), Bacillales (order), Bacillaceae (family), Bacillus (genus), Bacillus cereus group (no rank)

yycJ GBAA_5711

false

478

A0A4Y6HUD7

MTILSGTTAAPRVNGTTMNGHSKPHTNGVHLNGHAPKATTESPWPQSEEKTLLDKFVEAYYEFESYKSGQTVKVDGKTLSLAGVVAAARHHAKISLDDSASIKDKVVKSRKVIADKVASGASVYGLSTGFGGSADTRTDQPLSLGHALLQHQHVGVLPSSSQPLDVLPLSDPMSATSMPEAWVRAAMLIRMNSLIRGHSGVRWELIEKIAEIFDANITPVVPLRSSISASGDLSPLSYIAGTVVGNPSIRVFDGPAAFGAREMVPSAKALASHGIDPLPLASKEPLGILNGTAFSAAVGALALNEAVHFAMLAQVCTAMGTEALVGTRLSFEPFIHATCRPHPGQIEAARNIYNLLEGTTFASVHHEEVHIAEDQGTLRQDRYPLRTSPQFLGPQLEDILHAYVSVTQECNSTTDNPLIDGETGEIHHGGNFQAMAVTNAMEKTRLALHHIGKLLFAQCTELVNPAMNNGLPPSLAATDPSLNYHTKGIDIATAAYVSELGYLANPVSTHIQSAEMHNQAVNSLALISARATVNSLDVLSLLISSYLYILCQALDLRALQMEFVKGVEEIIREELSLLFASVVSPAELEALTSKVLSAAQTSLDTSGSMDAPARMKKMASTTTIPLFDFLTELTLPDAISSGIAMVSIPSFRSHLASRATALLDQLRRDYLSGQRGAAPASPYLNKTRMVYEFVRLTLGVKMHGSENYARFAKGLGVEDETIGQNISRIHEAIRDGKMQAITVAMFA

Phenylalanine ammonia-lyase 2 (EC 4.3.1.24) (PoPAL2)

Pleurotus ostreatus (Oyster mushroom) (White-rot fungus)

5,322

747

79,946

Cytoplasm;Lyase;Phenylalanine catabolism;Phenylpropanoid metabolism

GO:0005737; GO:0006559; GO:0009800; GO:0045548

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.

null

PF00221;

IPR001106;IPR024083;IPR008948;IPR022313;IPR005922;IPR023144;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Basidiomycota (phylum), Agaricomycotina (subphylum), Agaricomycetes (class), Agaricomycetidae (subclass), Agaricales (order), Pleurotineae (suborder), Pleurotaceae (family), Pleurotus (genus)

PAL2

false

479

A0A4Z3

MALEGLRAKKRLLWRLFLSAFGLLGLYHYWFKIFRLFEVFIPMGICPMAIMPLLKDNFTGVLRHWARPEVLTCTSWGAPIIWDETFDPHVAEREARRQNLTIGLTVFAVGRYLEKYLEHFLVSAEQYFMVGQNVVYYVFTDRPEAVPHVALGQGRLLRVKPVRREKRWQDVSMARMLTLHEALGGQLGREADYVFCLDVDQYFSGNFGPEVLADLVAQLHAWHFRWPRWMLPYERDKRSAAALSLSEGDFYYHAAVFGGSVAALLKLTAHCATGQQLDREHGIEARWHDESHLNKFFWLSKPTKLLSPEFCWAEEIGWRPEIHHPRLIWAPKEYALVRT

Alpha-1,3-galactosyltransferase 2 (EC 2.4.1.87) (Isoglobotriaosylceramide synthase) (iGb3 synthase) (iGb3S)

Rattus norvegicus (Rat)

10,116

339

39,548

Glycoprotein;Glycosyltransferase;Golgi apparatus;Manganese;Membrane;Metal-binding;Reference proteome;Signal-anchor;Transferase;Transmembrane;Transmembrane helix

GO:0001962; GO:0005794; GO:0005975; GO:0006688; GO:0016757; GO:0030259; GO:0031982; GO:0032580; GO:0046872; GO:0047276; GO:0071287

Evidence at protein level

5

SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:17206613, ECO:0000269|PubMed:18630988}; Single-pass type II membrane protein {ECO:0000269|PubMed:17206613, ECO:0000269|PubMed:18630988}. Note=Also found in numerous large vesicles throughout the cytoplasm of the soma.

null

TRANSMEM 12..31; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255"

PF03414;

IPR005076;IPR029044;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Mammalia (class), Theria (clade), Eutheria (clade), Boreoeutheria (clade), Euarchontoglires (superorder), Glires (clade), Rodentia (order), Myomorpha (suborder), Muroidea (clade), Muridae (family), Murinae (subfamily), Rattus (genus)

A3galt2

false

480

A0A509ADH4

MRMSKLYKNKEKENEKPSNEPPIKQDSLKRMSSKFLGNSLNSFDLSGKLEQVDEYLKKYPFIIEFGYKLGIKPSYIVVFGGSALFISLVLGWGAALICNLVGFAYPAYQSFKAVESQGHAETKLWLTYWVVFSLFFFIEYLIDIILFWIPFYYVIKLLFLLYLYMPQVRGAETVYNYIIRPILLKHEKTIDDTVHKISQTATNHLNQFTGNIAEKLVQEGVRRRNV

Protein YOP1 homolog (PbYOP1)

Plasmodium berghei (strain Anka)

5,823

226

26,311

Endoplasmic reticulum;Membrane;Reference proteome;Transmembrane;Transmembrane helix

GO:0005789; GO:0007033; GO:1990809

Evidence at protein level

5

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:32432369}; Multi-pass membrane protein {ECO:0000255}.

null

TRANSMEM 73..92; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q12402"; TRANSMEM 95..113; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q12402"; TRANSMEM 124..140; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q12402"; TRANSMEM 144..162; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q12402"

PF03134;

IPR004345;

null

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

YOP1 PBANKA_0414500

false

481

A0A509AFG4

MNQLCVERNLSISTAYIKSKPKKYIERIKKKKSSNKSIKSQHKFEGSKIANKNNELKDIKSKDPKHYENHINKNTKHKDILLKSKRSDNFKFSRRGFILSFTGNLEDFYNLSEEPLGKGTYGCVYKATDKLLKIQRAVKVVSKKKLKNIPRFRQEIDIMKNLDHPNVIKLLETFEDEEQIYLIMDLCTGGELFDKIIKKGSFVEMYASFIMKQIFSVLNYLHIRNICHRDIKPENFLFYDKSTESLIKIIDFGLAAYFNDIDYEMKTKAGTPYYVAPQVLTGCYDYKCDLWSAGVLFYIILCGYPPFYGESDHEILSMVKKGKYNFKGKEWNNISEEAKDLIKRCLTIDSGKRINASEALKHPWFKKKKGSFNLDVKMDIHVLENFKNYALLLKLQKLAMTIIAQQSNDYDLQQLKTVFLYLDEDGKGNITKNQLKKGLENSGLKLPQNFDVLLDQIDSDGSGRIDYTEFLAAALDRKHLSKKLIYCAFRVFDVDNDGEITTAELAHILYNGNKKGSITQKDVNQVKKMIQEVDKNNDGKIDFYEFCEMMKLKY

Calcium-dependent protein kinase 3 (EC 2.7.11.1) (PbCDPK3)

Plasmodium berghei (strain Anka)

5,823

554

64,328

ATP-binding;Calcium;Cytoplasm;Kinase;Magnesium;Metal-binding;Nucleotide-binding;Reference proteome;Repeat;Serine/threonine-protein kinase;Transferase

GO:0004674; GO:0005509; GO:0005524; GO:0005737; GO:0030335; GO:2000147

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16430692}.

null

PF13499;PF00069;

IPR050205;IPR011992;IPR018247;IPR002048;IPR011009;IPR000719;IPR017441;IPR008271;

null

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

CDPK3 PBANKA_0408200

false

482

A0A509AH51

MLNMVDQKKGINNGSSTGVINNINGKIKNEFIFMYLIAAGGFSCVYKIKKKKSNKFYALKKIKFSANESNYEKKVLLNLREIECLRKLKNHPNIVSMNDFWLEVVQTLSKSKRERRGRRKEQQREQMGDKRREKRQQQRREKRKEQNTNTKKRVLITLSDHKKKKLKHLSCPENALNISNITNNERNVLKKDNWKNLILLKNFKKEKHNYNFNHQIELNKYNIMCLWKILNQMCVCKNEKKNIESLLPEQLIKNFKNFLFEKYILAIYDDCSYLNNKNNKTFIFFNNNLGNILHYLWWSYLGKNGKEKKNDIFKLLKYVSDNIIKDNTNLYNIILEFRHSLIELSRFPSNELGNVILNMRIPPNGSCELSEYISNMAKINKLEIYRNKNTLEKFIFKINCNNFDVYKMWINFKNDIIYEGKDVYKEHRKINLKRKIIKKKDIWIKGKKEKHLKNTIGNKCIKKINIYYEKPIHVFVYKSLTYKRQKHHKLWRKHYNNKKNWKYCLNKHENSKKYILFSKICRLMKTQMNKFKREEKFEKKKKIAITNIKVNYNDFEQDISSFNIQIYNKKNKNQLINRIKEQYEQLSISLNPYKLTYENENILRYNEHNYLFGLKNDNEKENIYNAIYFLNFYIWIRREINEYAIISKKRQICQNSRNYQSKKKFYIKRHNQKTYFFENIIFYHYIIMLFLDIEKYKNKFVSLFQYNLYRKLLKISKRIVLMLHRIETNVICIFLLKHFEDYFIRKGIHIVQDKSDRSNKGDEIGIHKMVKIWKSMIAISLIFGKKMYKKKKNIFNFFIELFLNNIQINIFKKFEILYLIIYFYNYFEKSKQFDIEGIGDIIYVWLSLINLFYDDKGKCIKILSKIFAKLNKKLYYVYWGKLYIIMNWTTIVDTIFIRNVLSINREGNYYWVIIVLKMINYFVNVAYTLTRMDIFFIKVMIKFYTRIGSAAATNSVSKNSYNEIFNNIFTLNFMNYIIYNSYFENEKKNYDIYTKYAILFIYCFIIQAYYFDTLFNIRSLESNEIANNLFPGYNYSYKNILLFYERLGRVIKNSNNTKICKYMWRKFINMWSNSIVIKENIISCLTTSRHIYFNILMNFMKIYCLDNILHIKKKKKKMNTPIVLTSKNDLKKWKDCELTKNPKSVKKGILIKKKNRNNNKKYKKKLKETHFIYNIKKVLFKKLVNINIETILYEQNGQCYILVFGSVIKKKNGQIKVKDTKIVRDINIIRDYRIYFYNYLEYFYKNNAHISDNINLIYARKWPYNNKNAVKQFCPYFDKIKDGNRKDIVSLYGNKILVKQNFSKIGNKIKNKKNNLCKKKMRTQKSIYNSNYWREKKENKLLNGNVNIIKKYKSEKIKKKELENFFDNIVYSSENDDFKIIFENATNSNACSTVDLASPNELNTKRNNINKKLKFFKHKKNSKKQKNYKNHKSHKKIFFKSVNNANRFFVTNVEPNPIMSNNHQIADSNDIYNNFSIQKKYEYNHKNCGNIYNTKDCDENDSSYICFLINEHEGQVLSHRHKELYKNMLGMERGNILYRDNACKLKDDFSCLHDQCDNSMIKACGTNELIKESTKIKRENMDKINKMNEVNQHISLETLKYKCSFKKIDKNLIQNKKKIIIRKICQINKTFYFKYNKINDKKRIYFDSVLCKSERHKTYKKRNENIKVILLKTLKGESNEYVLTTYLTEIYSDNINDPFENSRKKINSNEIFYQKTFDMYCIEDEGEVYEEQKRVNKNNKKKKYINEMIKMDTIRTDFEDNFTNSYNKKCNILKMASNINNKNNSGKKERDIKRQFLITNKKKHENNIKIFYNLFKLEESNVNSNPQTNPYYETVIHDNEDNIFYCLYKYIQQQVYRYCNCDIDEYTSNCIDKNVNKWEWYGFIKENENYDKIKTEINSNSFYNCREKHNICNSYNSVYQLEFRKLGNASKEKNFEEKKKIIKIEFRKSFNNFKLPSLLCILKWDNFFKPHFIIRCDNFLHTYNIYFDFFILLMNLFHKGEGSNLYRFNSNKSIIYNPYLSHQIYMVTKYFISNVHKINNKLPIHLENDILEIYSYNRFLTIPNKCSFKNCGNDNNNYDQRSKKHYFTKCGILNTEKVKPSKKRRIGWDGQRQRKRKDIINTLNEENQNMFCKNKEKKEENYKKIDTNISQFSEKNPVSNIDNEKNKQNFIKNKKYKFNLYIRMEYCKDTIENYINRRTRINIKRNIEIINMIIMGLNYIHNNNIMHRDLKPSNIFISNNDIVKIGDFGLASYDYLDDHKINTTKEEEIQKDLIINKNCDKIFFCNKKKLFSNYNSVFPLENGQISDVHNTKGDYNESSISKSKKFAIQNKNRNLRSCKRIFQWWSTIGELNILSKNRRRLTKFKSGSNTIHIRKSTLDENIIVRHANKCHNLSFSQNREHIDRNRMKKCNIIKNHIIKSNKSEKMNISMNVFLRCTKTRRYFTDEDKSVETRKKCSKTSEEENGNICDTKKKKNDIGEKMDKNKIAAQKKKKKKENKHPIGRRSTNSSISSAIVVKRNAYCRLEIEKYFLSKSFQNCRSNKKKKYINIKTIKNKFCSASNKNFGAKWMRIYRKGLHHDDIQEKSADQTTEQMGGCNKTVASDFSSNLKNKKESINHTLGIGTKLYSAPEQLEGNKYTKSVDIFSLGLIIIDLFIKTETNMERTQILCNARERILPDLLIKKHPNVASLCKKMLSLDYKSRPTSAQLYNKIISAGDIFLPDKCP

Eukaryotic translation initiation factor 2-alpha kinase 2 (PbeIK2) (eIF2alpha kinase 2) (EC 2.7.11.1)

Plasmodium berghei (strain Anka)

5,823

2,724

327,427

ATP-binding;Coiled coil;Kinase;Membrane;Nucleotide-binding;Phosphoprotein;Protein synthesis inhibitor;Reference proteome;Serine/threonine-protein kinase;Transferase;Transmembrane;Transmembrane helix

GO:0004694; GO:0005524; GO:0010998; GO:0016020; GO:0017148; GO:0018105; GO:0085015

Evidence at protein level

5

SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.

null

TRANSMEM 25..45; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 674..694; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 719..739; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 801..821; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 833..853; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 877..897; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 909..929; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 997..1017; /note="Helical"; /evidence="ECO:0000255"

PF00069;

IPR011009;IPR050660;IPR000719;IPR008271;

null

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

eIK2 PBANKA_0205800

false

483

A0A509AHB6

MGCNQSKSANDVRGNKVNHVNSKKKNNKREDTNDGEEIAINPGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVLKKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWIKKYANNINKSDQKTLCGALSNMRKFEGSQKLAQAAILFIGSKLTTLEERKELTDIFKKLDKNGDGQLDKKELIEGYNVLRNFKNELGELKNVEEEVDNILKEVDFDKNGYIEYSEFISVCMDKQILFSEERLRRAFNLFDTDKSGKITKEELANLFGLTSISEKTWNDVLGEADQNKDNMIDFDEFVSMMHKICDHKTF

Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PbCDPK1)

Plasmodium berghei (strain Anka)

5,823

523

60,809

3D-structure;ATP-binding;Calcium;Cell membrane;Cell projection;Cilium;Cytoplasm;Flagellum;Host cell membrane;Host membrane;Kinase;Lipoprotein;Magnesium;Membrane;Metal-binding;Myristate;Nucleotide-binding;Palmitate;Phosphoprotein;Reference proteome;Repeat;Serine/threonine-protein kinase;Transferase

GO:0004674; GO:0005509; GO:0005524; GO:0005737; GO:0005886; GO:0020002; GO:0020005; GO:0031514; GO:0045727; GO:2000147

Evidence at protein level

5

SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P62344}; Lipid-anchor {ECO:0000250|UniProtKB:P62344}. Cell membrane {ECO:0000269|PubMed:22817984}; Lipid-anchor {ECO:0000250|UniProtKB:P62344}; Cytoplasmic side {ECO:0000250|UniProtKB:P62344}. Parasitophorous vacuole membrane {ECO:0000250|UniProtKB:P62344}; Lipid-anchor {ECO:0000250|UniProtKB:P62344}. Cytoplasm {ECO:0000250|UniProtKB:A0A2I0BVG8}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A0A2I0BVG8}. Host cell membrane {ECO:0000250|UniProtKB:P62344}; Lipid-anchor {ECO:0000250|UniProtKB:P62344}. Note=Calcium and/or autophosphorylation does not affect membrane localization. {ECO:0000250|UniProtKB:P62344}.

null

PF13499;PF00069;

IPR050205;IPR011992;IPR018247;IPR002048;IPR011009;IPR000719;IPR017441;IPR008271;

3Q5I;

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

CDPK1 PBANKA_0314200

false

484

A0A509AJA5

MKSITFFVFNICSILALLSHCEDNDIYSFDIVNETNWLKIAKNIFKGKSPSNFTIIPFNNTGSSNDNESNKEESVLLIRKKIKSNKNHDSSIISGDTVNGDISDLNYTASNFSDNSEDIEDNQKYPTTSYNSFNHLNSNIAFNEESEYIEINSESDLENKIKDINIKSNLEENNTMNESGKVDSKYELTGDEKCGKSLKLGNISNQTNQETITQSLSVGEILCIDLEGNAGTGYLWVLLGIHKDEPIINPENFPTKLTKKSFFSEEISVTQPKKYKIDEHDSSKNVNREIESPEQKESDSKPKKPQMQLLGGPDRMRSVIKGHKPGKYYIVYSYYRPFSPTSGANTKIIYVTVQ

Falstatin (Cysteine protease inhibitor) (PbICP)

Plasmodium berghei (strain Anka)

5,823

354

39,974

3D-structure;Cytoplasmic vesicle;Host cytoplasm;Protease inhibitor;Reference proteome;Secreted;Signal;Thiol protease inhibitor

GO:0004869; GO:0005576; GO:0020009; GO:0030133; GO:0030430

Evidence at protein level

5

SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20361051}. Cytoplasmic vesicle, secretory vesicle, microneme {ECO:0000269|PubMed:20361051}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:20361051}. Host cytoplasm {ECO:0000269|PubMed:20361051}. Parasitophorous vacuole lumen {ECO:0000269|PubMed:20361051}. Note=During the asexual blood stage, localizes to the parasitophorous vacuole (PV) and to exomembrane structures beyond the limits of the PV (By similarity). Localizes to punctate peripheral structures in schizonts and rings (By similarity). Released after host erythrocyte rupture (By similarity). Secreted by gliding sporozoites (PubMed:20361051). Localizes partially with micronemes at the apical pole of sporozoites (PubMed:20361051). Released into the host cytoplasm by sporozoites (PubMed:20361051). During the host liver stage and in late schizont and cytomere stages, localizes mainly to the PV, but is also present in the parasite cytoplasm (PubMed:20361051). After completion of daughter parasite development, localizes to the host hepatocyte cytoplasm following the rupture of the PV membrane (PubMed:20361051). {ECO:0000250|UniProtKB:Q8I333, ECO:0000269|PubMed:20361051}.

SIGNAL 1..21; /evidence="ECO:0000255"

null

PF12628;

IPR036331;IPR024321;

3PNR;

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

ICP PBANKA_0813000

false

485

A0A509AKL0

MDDDEIIPKKNHPSNERNKKKAILSHEDFTGEDSLMENHLELRDKLTEDIVTIKASLKNNLVCSTLNENEILALSNYMQFFVFKSGDMVIKQGEKGSYFFIINSGKFDVYVNDKKVKTLTKGSSFGEAALIHNTQRSATIKAGTNGTLWGVQRSTFRATLKQLSNRNFNENRSFIDSVSVFDMLTEAQKNMITNACVIQNFKPGETIVKQGDYGDVLYILKDGKATVYINDEEIRVLEKGSYFGERALLYDEPRSATIIAKEVTSCASICRKLLNVVLGNLQVVLFRNIMTEALQQSEIFKQISPDQLNDLADTAIVRDYPANYNILHKDKIKSVKYIIVLEGKVELFLDDESIGILTRGKSFGDQYVLNQKQKFKHTLKSLEVCKIALITESCLADCLGNNNIDASIDYNNKKSIIKKMYIFRYLTDKQCNLLIEAFKTTRYEEGDYIIQEGEVGSRFYIIKAGEVEIVKNNKRLRTLGKNDYFGERALIYDEPRTASVISTVNNLECWYVDKSVFLQIIEGPMLAHLEERIKMQDTKVEMSELLTERIIGRGTFGIVKLVLHEPTKIRYALKCVSKKSIIELNQQNNIKLEREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSRSQAQFYLGSIILAIEYLHERSIVYRDLKPENILLDKQGYVKLIDFGCAKKIHGRSYTLVGTPHYMAPEVILGKGYGCTVDIWAFGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVTDTDSINLIKRLLCRLPQGRIGCSINGFKDIKENSFFADFDWDRLAGRLLEPPLISKSETYAEDIDVKQIEQEEEDNANTEIDDENWDIDF

cGMP-dependent protein kinase (EC 2.7.11.12) (PbPKG)

Plasmodium berghei (strain Anka)

5,823

856

97,901

ATP-binding;cGMP;cGMP-binding;Cytoplasm;Endoplasmic reticulum;Kinase;Magnesium;Membrane;Metal-binding;Nucleotide-binding;Reference proteome;Serine/threonine-protein kinase;Transferase

GO:0004691; GO:0004692; GO:0005524; GO:0005789; GO:0005952; GO:0030553; GO:0046872

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19779564, ECO:0000269|PubMed:27425827}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8I719}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8I719}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8I719}. Note=Predominantly localizes to the cytoplasm during schizogony. {ECO:0000250|UniProtKB:Q8I719}.

null

PF00027;PF00069;

IPR000961;IPR002374;IPR018488;IPR000595;IPR018490;IPR011009;IPR000719;IPR017441;IPR014710;IPR008271;IPR035014;

null

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

PKG PBANKA_1008200

false

486

A0A509ALD0

MEIPNEEIKFLKKEDIKNINLNGMNKKERYEIWKKIPKVELHCHLDLTFSGKFFLKWVRKYNLQPNMTDDQVLDHYLFTKEGKSLAEFIRKAISVSDIYRDYDILEDLAKWAVIEKYKEGVVLMEFRYSPTFVSSSHGLDIELIHKAFVKGIKNATEMLNNKIYVALICISDTGHSAASIKHSGDFAIKHKHDFVGFDHGGREIDLKDHKDVYHSVRNHGLHLTVHAGEDATLPNLNTLYTAINILNVERIGHGIRVSESEELIELVKKNNILLEVCPISNLLLNNVKSMDTHPIRKLFDAGVKVSVNSDDPGMFLTDINDNYEKLYIHLNFTLEEFMTMNNWALEKSFVNDDIKSKLKTMYF

Adenosine deaminase (EC 3.5.4.4) (S-methyl-5'-thioadenosine deaminase) (EC 3.5.4.31)

Plasmodium berghei (strain Anka)

5,823

363

41,989

Hydrolase;Metal-binding;Purine salvage;Reference proteome;Zinc

GO:0004000; GO:0005829; GO:0006154; GO:0006166; GO:0009168; GO:0009897; GO:0043103; GO:0046103; GO:0046872; GO:0060169; GO:0090614

Evidence at protein level

5

null

PF00962;

IPR006650;IPR001365;IPR006330;IPR032466;

null

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

ADA PBANKA_0513600

false

487

A0A509AM03

MRTVFIYACIISLVLRTIPAHNDLMSKEKENKEKDVHKIIEDLRFLEKVDAILENSNMTIDDVKADADAYNPDEDAPKEELNKIEMEKKKAEEEAKNSKKKILERYLLDEKKKKSLRLIVSENHATSPSFFEESLIQEDFMSFIQSKGEIVNLKNLKSMIIELNSDMTDKELEAYITLLKKKGAHVESDELVGADSIYVDIIKDAVKRGDTSINFKKMQSNMLEVENKTYEKLNNNLKKSKNSYKKSFFNDEYRNLQWGLDLARLDDAQEMITTNSVETTKICVIDSGIDYNHPDLKGNIYVNLNELNGKEGIDDDNNGIIDDIYGVNYVNNTGDPWDDHNHGSHVSGIISAIGNNSIGVVGVNPSSKLVICKALDDKKLGRLGNIFKCIDYCINKKVNIINGSFSFDEYSTIFSSTIEYLARLGILFVVSSSNCSHPPSSIPDITRCDLSVNSKYPSVLSTQYDNMVVVANLKKKINGEYDISINSFYSDIYCQVSAPGANIYSTASRGSYMELSGTSMAAPHVAGIASIILSINPDLTYKQVVNILKNSVVKLSSHKNKIAWGGYIDILNAVKNAISSKNSYIRFQGIRMWKSKKRN

Subtilisin-like protease 1 (EC 3.4.21.62) (PbSUB1)

Plasmodium berghei (strain Anka)

5,823

599

67,314

Calcium;Coiled coil;Cytoplasmic vesicle;Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Protease;Reference proteome;Secreted;Serine protease;Signal;Zymogen

GO:0004252; GO:0005576; GO:0006508; GO:0030133

Evidence at protein level

5

SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8I0V0}. Parasitophorous vacuole lumen {ECO:0000250|UniProtKB:Q8I0V0}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:30941868}. Note=At the schizont stage, in merozoites, localizes to dense secretory granules called exonemes (PubMed:24348254). Just prior to egress secreted into the parasitophorous vacuole (By similarity). In male gametocytes, localizes to secretory organelles called male osmiophilic bodies (PubMed:30941868). {ECO:0000250|UniProtKB:Q8I0V0, ECO:0000269|PubMed:24348254, ECO:0000269|PubMed:30941868}.

SIGNAL 1..20; /evidence="ECO:0000255"

null

PF00082;PF18213;

IPR000209;IPR036852;IPR023827;IPR022398;IPR023828;IPR050131;IPR015500;IPR041089;

null

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

SUB1 PBANKA_1107100

false

488

A0A509AMC3

MYNKGINICLNEDNKCIILLHIIFNKCIVSFVASHILVEGKICFLNRIKNSKIFRRFGNINNHRRNNVKEYYKFVGRINKGKEKRNKCRIKLHRFYEYAKSYILKQIKWVLNKSKYIYFNIIYHLKTICYLKNAFFLQYTQRKYFSQNIENYIINSLPKHIQSFNPIKWSYYNNNEYASNYIIINNLNFIKYKNKYEKQYDIEMEEDINCKGANDIFYNSYNYCNNNNSNSKCDEKIEKNIVDKNIENKYNIKEYDKTNKSILFPIEEEFKKIIQIENNIERNYMVPNESNKNILYNIKNILEKIRNIEAISNINNYIDMKNTIESYKLNPDKCKEILHKDKDFRNKSKLCLSCFHNIIHKIIYYSKMENISFSDMYKQLLTNYNNTSCEYCNLINNSINSNNDFLSLYNDKNMYNWKNCEKNKFETLENEISCWNFNSSYGNHFQHIQKNSKIYRRILNEENEKAFNNIVGRNEMENDELYKRIHTENNYANQFTENNVDFGVYSDLREYNNGNEKYMLDENEMDQIIDEEVKKQEKNQNLNNMDFNNVNKKYNQLKDDNIIIFNKNNMHNNLYSNGLNDSNLEKNNILFPYEKYNNLDKNEMNLTKYSQNKQFYGQYKYDEAIYKYDLIVLDTSGYIYKVSTDGTYHWKYRIVKNIQYYINYEEENKIENYYNAFKKNNGKINMTHKDILRKNDYEQYHKLKLRAMKKLQYNNFIDVFNSNYKKNYPTYLNEQITEKDDIYKKKNYNYEKSKKKSKNKNAMKKLLSDYSGDLFYVDENNEAIPININIKDVVNNSPFKSTLFPNILFIGSRQSSIVNLDFDTGYVIKKYEENYDDLVKEKQKALPNKYEKFINKNSNVLHDKLEKYLDHSIDINDKNYYVNEEKDDLDKDYTIIDGKVAENNQQLDNIDLYNNEIETENNNGINHLLLIDGKGQIEEQSPNNGNKIIKGDVSNMTDECGTENCLSKHSKEEIEIANNKFNKNNKDKLLIQRTKIKNKKHFLMGKWYMNISNNNLLNINSSVLGINKKKRNSKKGENRNKKRKTQKRQLQISLVKWVIKAVDETSLKQKWITSWVDVGSIFITDSHKQDLSFINSLIDIDGNKLILRTLENNKVNKPYNNTISKNIEDAERNELEFASENYKNDIPNEIDEHNNKMGRNMNKLNSNIKSKIFIFSKEISSVFALQYKSKTNIFTLDTILKQNEKLFPEYDNIKPYSYNLLNLKNNSNALLLPFSSSNDYLKNNDKKNLPWNFNYDENGTNANNSIAFQNYNNFIVQRLNNISINITSIEKDLRYLLLSIIFVFDKHKKIPMNYIFQMKTLLHEYQKTKQKFMICLRGLNHNKNINIFSNHNDIRDTDIKHYGYNDYDYINKEMDAIDEPIHICEYTNKFIDLSFEGKEKCIDYCSMLNIWDKIFNNYTNHDDCLLLSNLYRILNSTYPLTNKDFNRIIDGIFLKNNESMLIKRRRKPNEGSRNHDLTEFSSQKHKKSWYWNIFYAITLVIVIPFIFIYRLFKKQTNNKNNNKIIMRKKKITDYDEDSNDTYDDELLNIDKVLLKRNKRKLANILKENGISSLNKTELEKYMKKSLKKAQDIEQLTLVDILARHARDSDSDSNFYDIHDGKYNLYPYYYSGQESKYSLPNMHYIDLSKSNSGETNKYDLNGNNLFYMHRRRAASQDVTYKQSFIVKKRVRSNYKLGNKYNKRNYTDYEKDKKNSSIKERNINEKAFDKSDFINFLKNFNKKFMKKNPFVDHLMKNNKTDSNNEFNNDNKEKSKYLYNEKYNLNSADEENKSPYAKKYSDEKKNRSKSSKYIENTQSNNNDNTNGNMNVGNHINNDKMNNKGSSARNLSIIQTSHIPYDAPLADFLENGRFTRTFQNISLIGQGGFGSVYKVSHRLEPGSPTYAVKFIYLKVSSLDNVNSRRYFREIAANRDIYSKHVVRYYTWWCEEPQFLPMDIIPKEIQNTLKKNKDPFKKVCNKNKKDNDYSSDCTVSSGENNKFDLKNYKKVITKKNSPKLKFYSDNDTPYNKRKNINQKNSFLNDKNLSDNIYIIENNKKKKKKKKKKKKIIYKEKKKGNIGINEDNKYSTFYEQNNPNNFSSTLQEYDPFGYGYLSENERDLIVFADNDESNGSGHSKKNDNDERKSLNNQNGIYNTGGDISKNGNVIHDDSNMLACQQSDKNSMTIKNTQGTSINGTINRNTISDETGTQGTNNNPKYSIDYHIDAIVKPKGESFTWVEKSPSNKYKKDSLDIINRNRKLIEEKNKKEKGQEKEKYKLKMNGELEKKENANKIKYYKKKNVGPEFSIVLLLQMEFCKGFTLRRWLDRSSRSDKPLYFTYGDKNTNHPLEFDLFKQLIKGLKDIHSTCFIHRDLKPENIFVDLDTYILKIGDLGLVRFIEEKKRENDLNNIDNFKDNIYTEINHNTITSQISLKGQMIGTPGYTAPEGGALCDEKADIYSAALILLELLCPRFNTIMERYKTLNDFRNYYTVPDYVKIHLNPWYILMLQMSKPNPADRPSAADLYNKIKVLLDPHLTDFTFSFNDINNDDLEYTGNRNVINSTNPNGDIKENVNQNNLVDDKGNNNIINGNEVDH

Eukaryotic translation initiation factor 2-alpha kinase PK4 (eIF2alpha kinase PK4) (EC 2.7.11.1) (Protein kinase PK4) (PbPK4)

Plasmodium berghei (strain Anka)

5,823

2,591

306,873

ATP-binding;Endoplasmic reticulum;Kinase;Membrane;Nucleotide-binding;Phosphoprotein;Protein synthesis inhibitor;Reference proteome;Serine/threonine-protein kinase;Transferase;Transmembrane;Transmembrane helix

GO:0004694; GO:0005524; GO:0005634; GO:0005789; GO:0010998; GO:0017148; GO:0018105; GO:0018107

Evidence at protein level

5

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29241041}; Multi-pass membrane protein {ECO:0000255}.

null

TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1489..1509; /note="Helical"; /evidence="ECO:0000255"

PF00069;

IPR050339;IPR011009;IPR000719;IPR008271;

null

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

PK4 PBANKA_1126900

false

489

A0A509APT1

MKVTFGNEYIKNFLGEFIGTFVLMFLGEGTTANHFAVPIKNDWLRLCIGWGLGVFFGILISAKLSGAHLNLAVTVGLSTIKKFNYKQIPLYFAGQLLGALSATASVYGLYYGFVSDQTIPKFSWETGKHANVHIASAFMHEFILTGILLLIILSVTDENICGKFHVLKVSSIVGLAIICIGISFGGNTGFALNPSRDLGARILSAIAYGFEAFTRDKCYFWIPLIAPIIGSIIFCQIYDKIVAPLVVISEHDKGALEI

Aquaglyceroporin (PbAQP) (Aquaporin-1)

Plasmodium berghei (strain Anka)

5,823

258

28,141

Cell membrane;Membrane;Reference proteome;Transmembrane;Transmembrane helix;Transport

GO:0005886; GO:0006833; GO:0015204; GO:0015250; GO:0015254; GO:0015793; GO:0044002; GO:0071918

Evidence at protein level

5

SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17284593, ECO:0000269|PubMed:29330527}; Multi-pass membrane protein {ECO:0000255}.

null

TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 46..66; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 134..154; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000255"

PF00230;

IPR023271;IPR000425;IPR050363;

null

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

AQP PBANKA_0915600

false

490

A0A509APX1

MKETDKIKSEVLNLMQLDGKREHINKNNKLYRKVIINPTSEDDLQKFCKNYFRIYQFSLYNFIRRLISLDAVIVYTLFMTVYIFSEISQGITKKYLFVDTAISLFLNIGILVVIESLFELKLLKDIKNANSQHYLRIVPKMSYFEKVMTKDIKVGNIIRVFQGEEFPADVVILYSKKNTNAVVDSFKIDGLYNKSIKYPVEKYKIDRDYLKMLSEINGVIKCELPNKNVFCFQGTYKLDKHPRSLHLSYENFALQSSILKGAEYIDGVVVYTGADTKKNLNIPRKIEENMTFCIKMNNVVYYLIFMYILFVLLSIIIKAIFYRKGKLLENSNDTFFTVLEDFIGLYILVLPVMLYSEKSLIYIIQSLKIERDTRMNKDENSNNTKVFNKNKNDALGTVDIIATARNGVLVNKKEILVSCTINNVLYSKKKFIISDEFLKLPSLNILDAERTNVSELLNLDERIFKDPENIFFPSRDFNNFLKILGNNTNPIYDPINGDFSKILKEIYRNYLNEEFLYKKIKLSSSVKSLLDNGYNQFLEDCESSYDCKEIIEDGLKNNEQSEKIEEFILGICACNRIIIYNEKFGDIEMKDNINEKSTSEHMNYDKDREVENIESENKYAVDSDGEENMNTIEHEDICLFNTSKNIGFHIYCYKKCLFFYNLKNICKEYYIICFHDFLRSNNYTMCILKNKKELDKGILYIRGYDFNILPYLCKNKNDINKIKKTIKIHTANYLKVILICKKNITNEDIAKYIYLKSVRSKFSFKFFDIIKTFFLYDLECIGIIGLKNDLNDGVVETFNDINNFDIRSWIFTNDSSKNTYLTALQCNLITPNSNLFIINFLNPDHSDEETVANYLFNNFLFSMENMKSRSYAIAINEMSLKNIMRSRYALKVFLCIIMRATVVLFCKLNNETKGKIISKFLSYTTPKLTVLGVGSTLNDAYLLKNTTISVCLTLNKQVNALYSISDYAMEEFKYVGELLILGRLNRFSLCRAFLWIIYLKVMIGSFYFFHNFDNFFSGSSISSILYSQTAFAIFHYSLIVAFASYEIDIPYKFIRNFPYIYQLARRKYFLNNTIIFLNIVESIFSSFISYYILRGNLFNLITHRKFTFHIFVLNFFLISEKILLFSKTWHIFFFIMTIIIVSILFIYINIYTLVDCLITGKCEFSLFDPEDSYFWISLLPILYINFIIDKFMKFVKNKIYPDITYHLSNTLKIETQEKFATNNKREEVITDKNIEKLAPVPKSYIIKEDNAYYGKSKKNKYIFDTLRKIIDIKIKYRNQQLNLEYKTYEKRNKLKLRIIILLLFIIFLITFTIQIIISKFIEKKLHSLSYLTVIYYIVAVLYLIKILIRNKTNYTYFYIIGKLLLVIGYLLEISENSVNNIINMLVTYSFTVCYIFFISFKILEGLVMCIIILSIAIWVYYHKNNNLNAMCTDFCDNPYTSLDNLEYINISCICKQQIFTFLICTLSFTLICLFMKYYEIYYLKKKFLTRYKQKVNLGKQIEILHTMLPSFLVEYLLVSDPKADGIMVGKNISGEDRGIISVIFCDIDDFQTMVSTLEPHTLVQTLDNLYLYFDKCIKYFNCIKIETVFESYLAASGLSEKKNNCVHKIKYDTKCAIKMAIAQLSAKYYISYKVLDTLSNNKDSNSIFPIESKYIYKNISLRIGIHTGKAISGVIGSVKPQYSLFGDTVNTASRMKSTSLKDHIHVSYDTYKYLKDDKTLVWKERSIFIKGKGEMKTYLLVDILDNSKKDHTKALEESTSSIFRSNDEIVNKSELITKEKEFDKIEMPDKSEIIDETKKIFKKSEKPSTKKKKIKKENAKEKNINIKMKEMGEILNNYDKEKVYNCNKSDDGSNSIGQNDFLYSTKNYNYKKSKYLDLERLSTNKSFRRNVLAYNFESPINLPPKIGDNTKRNYDSDNFFTSPYIIDKNEKDEIRDTTNKALYIKKSKNIINRMREDSIDFKDEFSKENDKIKEYIKERITYRQKVTPNYFNFNNMSKYSNAFKKKKKKKKDIQKKYTYRQKTSFYNFLNKNDIINYNYSSEFEYFIDPKMKNKKPINFNNLFAKIYKKKLSLLNIKNEPINIKKKNIKNKSRDRIIFSSRRDEEHDDNQKMNKKLFSRTYAQKAEQTSHENIFTEMINDNFLKKEDKEQCEIRNENRCPTVFLIKRNKTTININKNRVLKRIFKDIITRKKIKRNRILKNKKLNYVNKNDNLGKKYEILNNICLVHKRAMTFVQYNTEDEEKKRTKRFHKNDEIFGSDMNISRNLNGSNSNIQNINRRSKNKAEDDLFIRNKVNLNNIKNNINLRKNIYKTDERGMQYNDLKGYDKKKNTEENNEDKEKKIEYDSNENIKNGFPKNEDKMIMKKRMISKRISFYSLKEYEKGDSFKSYDNSSCGIKSKKTNSIISDEEMNEYFNYNTEFNSNRNKNKQNKEFSLASKVNNIFKNIFKKNYISDKLKSGKYNTMSNSKSGQTNITTDNKKSQIKKNGDVNKANTNVSNKNSDFVTNFDNYNKNILKKLTSTLQINRKTSYFNRFYYKFKDEELEEEYTREYYQEIINIDLTKKLIIIFVISELILSLCNVIELSYYENKETPNDFIVIIWLIRSIYLFTITFIWLLLKTKLKEYKDNSSKMMWTTFILNIFLSSWGIIMIDLACIHYSNLVGNSRERSIFFMKDATELIISMQLIFVKNMLFKHKFFFFVFFFVFLMYSFFKLFVIHVCELRICCSILLILSINILYFWYSEYLDRTQYIIKRKRNRMERTSHDFLTRILPRQVLEEYQNDNLQLTYKHEKIAFLFADIVGFTKWSKTAAPKNVLKLLQKLISKIDKDTIKLGLYKLFTIGDAYVATSQPNASITDQTEAADGIISIFKLAKLILHNINTIKIQFNKHDFNMRIGLHYGSCVGGIIGSVRIRYDMWGLDVLIANHIESNGIPGEIVCSEQFKNFFLENEPHAKLNFWHYKTISINDKDIKIYVVEDKNYEEDYDPKIINYETLLKLREQNKVKG

Guanylate cyclase beta (PfGCbeta) (EC 4.6.1.2) (Guanylyl cyclase beta)

Plasmodium berghei (strain Anka)

5,823

3,004

354,776

cGMP biosynthesis;Glycoprotein;Lyase;Magnesium;Membrane;Metal-binding;Reference proteome;Transmembrane;Transmembrane helix

GO:0004383; GO:0005886; GO:0035556; GO:0045332; GO:0046872; GO:0140326; GO:2000147

Evidence at transcript level

5

SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.

null

TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 95..115; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 301..321; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 335..355; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 992..1012; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1023..1043; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1073..1093; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1106..1126; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1131..1151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1172..1192; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1298..1318; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1328..1348; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1354..1374; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1395..1415; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1458..1478; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1501..1521; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2564..2584; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2595..2615; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2635..2655; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2668..2688; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 2696..2716; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2723..2743; /note="Helical"; /evidence="ECO:0000255"

PF00211;PF16212;

IPR001054;IPR023298;IPR008250;IPR036412;IPR023214;IPR029787;IPR032630;

null

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

GCbeta PBANKA_1136700

false

491

A0A509AQ68

MAHVITRINAREILDSRGNPTVEVDLETTLGIFRAAVPSGASTGIYEALELRDNDKSRYLGKGVQQAIKNINEIIAPKLIGLDCREQKKIDNMMVQELDGSKTEWGWSKSKLGANAILAISMAICRAGAAANKTSLYKYLAQLAGKNTEKMILPVPCLNVINGGSHAGNKLSFQEFMIVPVGAPSFKEAMRYGAEVYHTLKSEIKKKYGIDATNVGDEGGFAPNILNAHEALDLLVASIKKAGYENKVKIAMDVAASEFYNIETKTYDLDFKTPNNDKSLVKTGQELVDLYIELVKKYPIISIEDPFDQDDWENYAKLTEAIGKDVQIVGDDLLVTNPTRIEKALEKKACNALLLKVNQIGSITEAIEACLLSQKNNWGVMVSHRSGETEDVFIADLVVALRTGQIKTGAPCRSERNAKYNQLFRIEESLGANGSFAGDKFRLQLN

Enolase (EC 4.2.1.11)

Plasmodium berghei (strain Anka)

5,823

446

49,026

Acetylation;Cell membrane;Cytoplasm;Cytoskeleton;Glycolysis;Isopeptide bond;Lyase;Magnesium;Membrane;Metal-binding;Nucleus;Phosphoprotein;Reference proteome;Ubl conjugation;Vacuole

GO:0000015; GO:0000287; GO:0004634; GO:0005634; GO:0005773; GO:0005856; GO:0005886; GO:0006096; GO:0009986

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21949403}. Nucleus {ECO:0000269|PubMed:21949403}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:W7JLR6}. Cell surface {ECO:0000269|PubMed:21949403, ECO:0000269|PubMed:24474798}. Cell membrane {ECO:0000250|UniProtKB:Q7RA60}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000250|UniProtKB:Q7RA60}. Vacuole {ECO:0000250|UniProtKB:Q8IJN7}. Note=Partially localizes to the nucleus in rings and trophozoites. Localization to the nucleus and food vacuole is higher in early and mid-stage trophozoites compared to the late-stage trophozoites and schizonts (By similarity). In the nucleus, localizes to heterochromatin region (By similarity). In rings, nuclear localization is dependent on the actin cytoskeleton (By similarity). Localizes to the cell surface of merozoites (By similarity). In gametocytes, predominantly localizes to the actin cytoskeleton (By similarity). In the trophozoite food vacuole, colocalizes with hemozoin, a product of heme detoxification (By similarity). In sporozoites, localizes to punctate structures beneath the cell membrane (By similarity). Localizes to the cell surface of ookinetes, especially on the apical pellicle complex that is involved in invasion (PubMed:21949403, PubMed:24474798). When phosphorylated at Thr-339, localizes to the cytoskeleton (By similarity). When phosphorylated at Ser-42, localizes to the cytoplasm (By similarity). When ubiquitinated at Lys-138, acetylated at Lys-133 and Lys-375 and phosphorylated at Tyr-139, localizes to the food vacuole (By similarity). When triubiquitinated at Lys-138, appears to colocalize with hemozoin in the food vacuole (By similarity). {ECO:0000250|UniProtKB:Q7RA60, ECO:0000250|UniProtKB:Q8IJN7, ECO:0000250|UniProtKB:W7JLR6, ECO:0000269|PubMed:21949403, ECO:0000269|PubMed:24474798}.

null

PF00113;PF03952;

IPR000941;IPR036849;IPR029017;IPR020810;IPR020809;IPR020811;

null

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

ENO PBANKA_1214300

false

492

A0A509AQE6

MCEHKANNKNDGEFVNLKEKNENNHCGNTKSTIADCDDDYSIITLCTKCLSTKTEVNKNKIILDSKALKDSRTKRRSSVNINIDILNNNLNLSPYFDRSQIVQETILMNNDDLEKLYELDKYKLGKGSYGNVVKAINKKTGQAKAIKIIDKKRINNIERLKREILIMKQMDHPNIIKLYEVYEDNEKLYLVLELCTGGELFDKIVKHGSFSEYETYKIMKQIFSALAYCHSKNIIHRDLKPENILYVDSSDDSPIQIIDWGFASKCMNNHNLKSVVGTPYYIAPEILKGKYDKKCDIWSSGVIMYILLCGYPPFNGKNNDDILKKVKKGEFVFDSNYWSKISLDAKELICECLNYNYKERIDVHKIVNHKWFIKFKNYNHITINKHLSKELIEKFKKFHKLCKIKKLAITCIAYQLNKKKFGKMKKTFEAFDHNGDGVLTISEIFQCLKVGDNEIDRDLYYLLKQLDTDGNGLIDYTEFLAACLDHSILEQDAVCRNAFKIFDANGDGIITKDELLNVLSFSNDQMPFSKEIIENVIKEVDANNDGYIDYDEFYKMMSGRQS

Calcium-dependent protein kinase 5 (EC 2.7.11.1) (PbCDPK5)

Plasmodium berghei (strain Anka)

5,823

562

65,108

ATP-binding;Calcium;Cell membrane;Cytoplasm;Cytoplasmic vesicle;Kinase;Lipoprotein;Magnesium;Membrane;Metal-binding;Nucleotide-binding;Palmitate;Phosphoprotein;Reference proteome;Repeat;Serine/threonine-protein kinase;Transferase

GO:0004674; GO:0005509; GO:0005524; GO:0005886; GO:0031410; GO:0033163; GO:2000147

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A0A5K1K8H0}. Cytoplasmic vesicle, secretory vesicle, microneme membrane {ECO:0000250|UniProtKB:A0A5K1K8H0}; Peripheral membrane protein {ECO:0000250|UniProtKB:A0A5K1K8H0}; Cytoplasmic side {ECO:0000250|UniProtKB:A0A5K1K8H0}. Cell membrane {ECO:0000250|UniProtKB:A0A5K1K8H0}; Peripheral membrane protein {ECO:0000250|UniProtKB:A0A5K1K8H0}; Cytoplasmic side {ECO:0000250|UniProtKB:A0A5K1K8H0}. Note=During the late stages of schizogony, localizes to the cytoplasm in immature daughter merozoites, co-localizes with AMA1 to a subset of micronemes and to the apical region in maturing daughter merozoites, and near the plasma membrane in mature daughter and free merozoites. {ECO:0000250|UniProtKB:A0A5K1K8H0}.

null

PF13499;PF00069;

IPR050205;IPR011992;IPR018247;IPR002048;IPR011009;IPR000719;IPR008271;

null

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

CDPK5 PBANKA_1351500

false

493

A0A509AST0

MKLLGNSKYFFVVLLLCISVFLNGQEILDEIKYSEEVCNEQIDLHILLDGSGSIGHSNWISHVIPMLTTLVDNLNISRDEINISMTLFSTYARELVRLKRYGSTSKASLRFIIAQLQNNYSPHGTTNLTSALLNVDNLIQKKMNRPNAIQLVIILTDGIPNNLKKSTTVVNQLKKKDVNVAIIGVGAGVNNMFNRILVGCGKLGPCPYYSYGSWDQAQTMIKPFLSKVCQEVEKVALCGKWEEWSECSTTCDNGTKIRKRKVLHPNCAGEMTAPCKVRDCPPKPVAPPVIPIKVPDVPVKPVEPIEPAEPAEPAEPAEPAEPAEPAEPAEPAEPAEPAEPAEPAEPAEPAEPAEPAEPAEPAEPAKPAEPAEPAEPAEPAEPVNPDNPILPIKPEEPSGGAEPLNPEVENPFIIPDEPIEPIIAPGAVPDKPIIPEESNELPNNLPESPSDSQVEYPRPNDNGDNSNNTINSNKNIPNKHVPPTDDNPYKGQEERIPKPHRSNDEYIYYNNANNNDKLEPEIPSKDYEENKSKKQSKSNNGYKIAGGIIGGLAIIGCIGVGYNFIAGSSAAAMAGEAAPFEDVMADDEKGIVENEQFKLPEDNDWN

Thrombospondin-related anonymous protein (Thrombospondin-related adhesive protein) (PbTRAP)

Plasmodium berghei (strain Anka)

5,823

606

65,959

3D-structure;Cell membrane;Cytoplasm;Membrane;Reference proteome;Signal;Transmembrane;Transmembrane helix

GO:0005737; GO:0005886

Evidence at protein level

5

SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11927544, ECO:0000269|PubMed:9041516}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:9041516}.

SIGNAL 1..24; /evidence="ECO:0000255"

TRANSMEM 544..564; /note="Helical"; /evidence="ECO:0000255"

PF00090;PF00092;

IPR050525;IPR000884;IPR036383;IPR002035;IPR036465;

2EPH;2PC4;

cellular organisms (no rank), Eukaryota (domain), Sar (clade), Alveolata (clade), Apicomplexa (phylum), Aconoidasida (class), Haemosporida (order), Plasmodiidae (family), Plasmodium (genus), Plasmodium (Vinckeia) (subgenus), Plasmodium berghei (species)

TRAP PBANKA_1349800

false

494

A0A517FNB9

MEGLLLLLPTAIIALYLYISLIRRSRKKHNLPPGSDGWPFLGETFSYLKPHSAISIGRFMEDHISRYGKIYRSNLFGEPTIVSADAELNRFVLQNEGRLFECSYPRSIGGILGKWSMLVLVGDMHRDMRMISLNFMSAARLRTRLMPEVERQTLLVLRSWREGSTFSAQEEAKKFTFNLMAKHIMSMDPGEPETEMLRREYITFMKGVVSAPLNFPGTPYWKALKSRSSILAVIERKMEERIGRRDRGDGGVEDDDLLGWAMNQSNLLKEQILDLLLSLLFAGHETSSMALALAIYFLESCPEAVRDLRDEHLAISMSGKEGECGLSWDQYKQMEFTHCVINESLRLGNVVRFVHRKAIQDVQYKGYDIPCGWKVLPVFAAVHLDSTLYSDPHRFNPWRWQSSSSKTTAANFMPYGGGLRLCTGSELAKLEMAVFLHHLVLNYQWKLAEPEQAFAYPFLDFPKGLQIKVRAIT

Cholesterol 22-monohydroxylase CYP90B52 (EC 1.14.14.-) (Cytochrome P450 CYP90B52) (PpCYP90B52)

Paris polyphylla (Daiswa polyphylla)

49,666

473

54,036

Brassinosteroid biosynthesis;Cholesterol metabolism;Iron;Lipid biosynthesis;Lipid metabolism;Membrane;Metal-binding;Oxidoreductase;Steroid biosynthesis;Steroid metabolism;Sterol metabolism;Transmembrane;Transmembrane helix

GO:0004497; GO:0005506; GO:0006694; GO:0008203; GO:0010268; GO:0016020; GO:0016132; GO:0016705; GO:0020037

Evidence at protein level

5

SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.

null

TRANSMEM 2..22; /note="Helical"; /evidence="ECO:0000255"

PF00067;

IPR001128;IPR002401;IPR036396;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), Liliopsida (clade), Petrosaviidae (subclass), Liliales (order), Melanthiaceae (family), Paris (genus)

CYP90B52

false

495

A0A517FNC5

MAPVVILFFLFPTLLVLVVAVLGLRGGDDSWKKRGLKVPPGSMGWPLLGETIAFRRLHPCTSLGEYMEEHVNKYGKIYRSNLFGAPTIVSADAELNRFVLMNDERLFEPCFPKSVADILGHTSMLVLTGEMHRYMKSLSVNFMGIARLRNNFLGDSELYITQNFNRWKENIPFPAKEEACKVTFNLMVKNILSLNPGEPESEHLRKLYMSFMKGVVAIPLNLPGTAYKKAIQSRATILKMIEKLMEERIRNKKAGTDKIGEADLLGFILEQSNLDAEQFGDLLLGLLFGGHETSATAITLVIYFLYDCPKAVDHLREEHLGIVRAKKARGEPPALTWDDYKQMEFSQCVVSETLRLGNIIKFVHRKAKTDVQFKGYDIPKGWSVIPVFAAAHLDPSVYENPQKFDPWRWQTISTGTARIDNYMPFGQGLRNCAGLELAKMEIVVFLHHLTLNFDWEMAEPDHPLAYAFPDFPKGLPIKVRRLALK

Cholesterol 16,22-dihydroxylase CYP90G4 (EC 1.14.14.-) (Cytochrome P450 CYP90G4) (PpCYP90G4) (Protein DWARF 4 homolog) (PpDWF4) (Steroid 22-alpha-hydroxylase CYP90G4) (EC 1.14.14.-)

Paris polyphylla (Daiswa polyphylla)

49,666

485

54,979

Cholesterol metabolism;Heme;Iron;Lipid biosynthesis;Lipid metabolism;Membrane;Metal-binding;Monooxygenase;Oxidoreductase;Steroid biosynthesis;Steroid metabolism;Sterol metabolism;Transmembrane;Transmembrane helix

GO:0004497; GO:0005506; GO:0006694; GO:0008203; GO:0010268; GO:0016020; GO:0016132; GO:0016135; GO:0016705; GO:0020037

Evidence at protein level

5

SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.

null

TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"

PF00067;

IPR001128;IPR017972;IPR002401;IPR036396;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), Liliopsida (clade), Petrosaviidae (subclass), Liliales (order), Melanthiaceae (family), Paris (genus)

CYP90G4 DWF4

false

496

A0A517FNC6

MSDSDITFYCLSSILSVLLIFIFILIKRKQAKPKLNLPPGKMGWPFLGETIGYLKPYSATTLGEFMDQHIARYGKIYKSKLFGEPAIVSADAGLNRFILQNEGKLFECSYPRSIGGILGKWSMLVLVGDMHRDMRLISLNFLSHARLRTHLLKEVEKHTRLVISSWKENSTFAAQDEAKKFTFNLMAEHIMSLQPGKIETEKLKKEYVTFMKGVVSAPLNFPGTAYWKALKSRGTILKFIEGKMEERIKRMKEGNENLEEDDLLNWVLKHSNLSTEQILDLILSLLFAGHETSSVSIALAIYFLPGCPQAILQLREEHKEIARAKKQAGETELTWEDYKKMEFTHCVVNETLRLGNVVRFLHRKALKDVRYKGYDIPCGWKVLPVIAAVHLDPLLFDQPQHFNPWRWQNNGNCPNFSGASSNSNNIFLPFGGGPRLCAGSELAKLEMAVFIHHLILNYHWELTDNNDQAFAYPFVDFPKGLQIRVQSHSLI

Cholesterol 22-monohydroxylase CYP90B51 (EC 1.14.14.-) (Cytochrome P450 CYP90B51) (PpCYP90B51)

Trigonella foenum-graecum (Fenugreek)

78,534

491

56,049

Brassinosteroid biosynthesis;Cholesterol metabolism;Heme;Iron;Lipid biosynthesis;Lipid metabolism;Membrane;Metal-binding;Monooxygenase;Oxidoreductase;Steroid biosynthesis;Steroid metabolism;Sterol metabolism;Transmembrane;Transmembrane helix

GO:0004497; GO:0005506; GO:0006694; GO:0008203; GO:0010268; GO:0016020; GO:0016132; GO:0016705; GO:0020037

Evidence at protein level

5

SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.

null

TRANSMEM 6..26; /note="Helical"; /evidence="ECO:0000255"

PF00067;

IPR001128;IPR017972;IPR002401;IPR036396;

null

cellular organisms (no rank), Eukaryota (domain), Viridiplantae (kingdom), Streptophyta (phylum), Streptophytina (subphylum), Embryophyta (clade), Tracheophyta (clade), Euphyllophyta (clade), Spermatophyta (clade), Magnoliopsida (class), Mesangiospermae (clade), eudicotyledons (clade), Gunneridae (clade), Pentapetalae (clade), rosids (clade), fabids (clade), Fabales (order), Fabaceae (family), Papilionoideae (subfamily), 50 kb inversion clade (clade), NPAAA clade (clade), Hologalegina (clade), IRL clade (clade), Trifolieae (tribe), Trigonella (genus)

CYP90B51

false

497

A0A571BEE2

MSIPRFLKVTYGAYDNYIPVSELSKKSWNQQYFSLAFPKPPRPGKKRRSLPSQLQNNTAPVIDEEKLGVHRPPLWMHRSLMRISERPSVYLAARKGLIPKPLHFGKGESKSVGTHKSLASEKTKKEVKMKKDGFEAKEKTALKTDKEGSPKPAKKNIPRDSQKDKGRVSSDSEGEKAGVKKGSKKVKNTPKGKDSASESEGEKAGSKKEAKTTKKGSKDKVSATESGGEKAGSKKEAKATKKGSKDKVSGTESGGEKAGSKKEAKTTKKESKDKVSATESGGEKAGSKKEAKDDKKDATSSQETLLSTAADKDGKKKEEKPVKQSSKSKDTVKDSASEKGDEKKEDKKEGKKEKKKKDGEGKEGGKKEKKDKKDKKDKKDKKDKKDKKDKKEKDKKDKKDKKDKKDKKDKKDKKDKKDKKAK

Cylicin-2 (Cylicin II)

Mus musculus (Mouse)

10,090

422

46,653

Alternative splicing;Cytoplasm;Cytoskeleton;Developmental protein;Differentiation;Reference proteome;Repeat;Spermatogenesis

GO:0001675; GO:0005200; GO:0007283; GO:0007338; GO:0033150; GO:0098727; GO:1905198; GO:1905199

Evidence at transcript level

5

SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca, calyx {ECO:0000269|PubMed:38013430}. Cytoplasm, cytoskeleton, perinuclear theca {ECO:0000269|PubMed:38013430}. Note=Localizes to the subacrosomal layer of the perinuclear theca in round and elongating spermatids. Localizes to the calyx, also known as post-acrosomal region, in spermatozoa. {ECO:0000269|PubMed:38013430}.

null

PF15241;

IPR026189;IPR029354;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Deuterostomia (clade), Chordata (phylum), Craniata (subphylum), Vertebrata (clade), Gnathostomata (clade), Teleostomi (clade), Euteleostomi (clade), Sarcopterygii (superclass), Dipnotetrapodomorpha (clade), Tetrapoda (clade), Amniota (clade), Mammalia (class), Theria (clade), Eutheria (clade), Boreoeutheria (clade), Euarchontoglires (superorder), Glires (clade), Rodentia (order), Myomorpha (suborder), Muroidea (clade), Muridae (family), Murinae (subfamily), Mus (genus), Mus (subgenus)

Cylc2

false

498

A0A5B8NIM2

MDAAVDLLDPSKALNLKHIRQQLIRMEDTITFQLIERVQFPLNRTVYEPGAVKIPNSNLSFLDWTLREREKTDSLIRRYQSPDEHPFFPDALLKPILQPLIYPKILHRNNINLNDKIKKYFTDQVLPSICHDFGREDRGEQAENYGSTVTADIQCLQTLSRRIHFGKWVAESKYIDDPQGFAKLIKAGDRQAIGKAITKPAVELQVLERIRLKSRTYSTDPCESDDPEPKINVDAVVAMYRDCVIPLTKEVEIDYLMQRLSD

Chorismate mutase (EC 5.4.99.5) (EqCMU)

Erysiphe quercicola (Hevea powdery mildew)

425,177

262

30,282

Amino-acid biosynthesis;Aromatic amino acid biosynthesis;Cytoplasm;Host cytoplasm;Isomerase;Phenylalanine biosynthesis;Secreted;Tyrosine biosynthesis;Virulence

GO:0004106; GO:0005576; GO:0005737; GO:0006571; GO:0009094; GO:0030430; GO:0046417; GO:0140502

Evidence at protein level

5

SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:33010586}. Secreted {ECO:0000305|PubMed:33010586}. Host cytoplasm {ECO:0000305|PubMed:33010586}. Note=Appears to be secreted despite an apparent lack of a secretory signal. {ECO:0000305|PubMed:33010586}.

null

PF01817;

IPR036263;IPR008238;IPR037039;IPR002701;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Fungi (kingdom), Dikarya (subkingdom), Ascomycota (phylum), saccharomyceta (clade), Pezizomycotina (subphylum), leotiomyceta (clade), sordariomyceta (clade), Leotiomycetes (class), Erysiphales (order), Erysiphaceae (family), Erysiphe (genus)

CMU

false

499

A0A5E4M3Q4

MSVCVSPLVQATILMTEESLTCPQCPKSFSSTKLLQQHQQMFHTDKSVLLSLKSTDAPVGMDRAFICETCGKAFRFRSNLAEHRSVHTALKPYVCKFCGKSSRLKGNLTKHILKHHKKEQNEAIAKDDIIVKKAPKIVTKDNGPTTNGSTPTTSTATPSVITVSSALASSNGHNNNNNNHAVNNNLRTIKMELEDPDYNLIAKSAPTPVVSKIVATHTVTPRSRPTPKDIKEILETIAPSVGVSETPEEMCLLPKDASSESDRSVLISLGFDFGSTLSLNHQQLQQVVRELKGELSISPDTVQSDHSDDFEQDSPPPMAIANISTVGGEATLAAMIVAATNASGQRGDGTPDSTDTQKGCSPQRELSPESDPSTSSGDSCPSPPKMLHCKECGTLVRKSSHLPIHMTMSHGYPPPLVAAPVEEKPAPEQPVNASSLHNELRVISNAICELKAQQAATPRVEQALTYIDSRVGKLERSLETALNSIYTLVQLQTGMTSSVNRLREDSTKNFSDLKTRMEMSLSPIKPFQQRFSRERSSSSSVERSPSRERSRSPL

Zinc finger protein syd-9 (Synapse defective protein 9)

Caenorhabditis elegans

6,239

554

60,211

Alternative splicing;Metal-binding;Nucleus;Reference proteome;Repeat;Zinc;Zinc-finger

GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0008270; GO:0016607

Evidence at protein level

5

SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16803962}. Nucleus speckle {ECO:0000269|PubMed:16803962}.

null

PF00096;

IPR050888;IPR036236;IPR013087;

null

cellular organisms (no rank), Eukaryota (domain), Opisthokonta (clade), Metazoa (kingdom), Eumetazoa (clade), Bilateria (clade), Protostomia (clade), Ecdysozoa (clade), Nematoda (phylum), Chromadorea (class), Rhabditida (order), Rhabditina (suborder), Rhabditomorpha (infraorder), Rhabditoidea (superfamily), Rhabditidae (family), Peloderinae (subfamily), Caenorhabditis (genus)

syd-9 tag-239 ztf-10 ZK867.1

false