text
stringlengths
174
10k
embeddings_A
list
embeddings_B
list
Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy–induced second malignant neoplasms (SMNs). We identified two variants at chromosome 6q21 associated with SMNs in survivors of Hodgkin's lymphoma treated with radiation therapy as children but not as adults. The variants comprise a risk locus associated with decreased basal expression of PRDM1 (encoding PR domain containing 1, with ZNF domain) and impaired induction of the PRDM1 protein after radiation exposure. These data suggest a new gene-exposure interaction that may implicate PRDM1 in the etiology of radiation therapy-induced SMNs.
[ 0.018645234405994415, -0.004260019399225712, -0.01341119222342968, 0.030590718612074852, 0.01911068707704544, -0.001867129234597087, 0.012759639881551266, 0.019569139927625656, -0.012781200930476189, 0.004929225891828537, -0.011931726709008217, 0.010455561801791191, -0.008881978690624237, 0.021988630294799805, -0.009788515977561474, 0.004266887903213501, -0.03744027763605118, 0.00744955288246274, 0.017574496567249298, 0.02736390382051468, 0.013084120117127895, -0.012013707309961319, 0.012103716842830181, 0.004092811606824398, 0.013916040770709515, 0.0005761957727372646, -0.029611488804221153, -0.027068177238106728, -0.007555488031357527, -0.020952312275767326, 0.02076289989054203, 0.02631082572042942, -0.008797804825007915, 0.024507250636816025, 0.004481120966374874, -0.010655315592885017, -0.01100471243262291, 0.024748511612415314, 0.009659533388912678, -0.006066321395337582, -0.010069138370454311, -0.01741994172334671, 0.010363401845097542, 0.005601047072559595, -0.010463384911417961, -0.014474988915026188, -0.008230691775679588, 0.0023270421661436558, 0.011772776022553444, 0.006770975887775421, -0.017314443364739418, -0.004913661163300276, -0.019751358777284622, -0.0018939748406410217, -0.00785696879029274, 0.010633481666445732, 0.022163819521665573, 0.008570274338126183, -0.03433249518275261, 0.021893490105867386, -0.008259396068751812, 0.0028696907684206963, 0.0038460379000753164, 0.015228943899273872, -0.0027047395706176758, -0.06616747379302979, 0.06349433213472366, -0.03508882224559784, -0.018621958792209625, -0.001279593212530017, 0.0026017825584858656, 0.005606124177575111, 0.008132689632475376, -0.0025051445700228214, -0.06775239109992981, -0.0054753804579377174, -0.026939578354358673, -0.01011691428720951, 0.017333952710032463, 0.03045695647597313, 0.022502761334180832, -0.007586225867271423, -0.019696131348609924, 0.00857012253254652, 0.007485259789973497, -0.016824793070554733, -0.048758745193481445, -0.021502941846847534, 0.01445170771330595, -0.01783791556954384, 0.04194874316453934, 0.01218180451542139, -0.05290012061595917, 0.010299480520188808, -0.008589153178036213, -0.025012560188770294, 0.008246994577348232, 0.014632165431976318, 0.03161609172821045, -0.031128741800785065, -0.009973006322979927, 0.017805779352784157, 0.024214010685682297, -0.002171809319406748, -0.04340536147356033, 0.011112418957054615, 0.004162729252129793, -0.013420650735497475, 0.0393776074051857, 0.018017878755927086, -0.027648605406284332, 0.023910604417324066, -0.005068250931799412, 0.021010594442486763, 0.004229738377034664, -0.015211056917905807, 0.018723323941230774, 0.01081254705786705, 0.014236540533602238, 0.0031276466324925423, 0.012122350744903088, -0.004674757830798626, -0.014614862389862537, 0.023496177047491074, 0.0021162936463952065, 0.0029178899712860584, 0.01083228550851345, 0.007257900200784206, -0.014759568497538567, 0.00018770713359117508, -0.012161818332970142, 0.00985187292098999, 0.005345809273421764, -0.008899684995412827, -0.02554374188184738, -0.0003619040362536907, -0.03528917580842972, 0.010035049170255661, -0.009805579669773579, 0.0010365541093051434, 0.007583483587950468, 0.016814440488815308, 0.0007427716627717018, 0.010669457726180553, -0.017673801630735397, 0.009312586858868599, -0.006596056278795004, -0.001899859169498086, -0.026935691013932228, -0.0298367440700531, -0.010819192044436932, -0.0018157294252887368, 0.004226952791213989, -0.02098042145371437, 0.016435906291007996, 0.01904168911278248, -0.009329494088888168, 0.0003778517711907625, -0.004098901525139809, 0.013947639614343643, -0.013237014412879944, -0.011088398285210133, 0.012249521911144257, 0.012592263519763947, 0.015172302722930908, 0.009396148845553398, 0.03816603869199753, -0.009328106418251991, 0.006616375409066677, 0.009784411638975143, -0.004169275052845478, -0.018908517435193062, 0.01042165793478489, 0.008197628892958164, 0.004127083346247673, 0.0040980139747262, -0.02863045036792755, 0.008375359699130058, -0.008903712965548038, 0.0656849592924118, 0.0026055467315018177, 0.009218607097864151, -0.014725128188729286, -0.0248042494058609, 0.006296512670814991, -0.022942326962947845, 0.009415538981556892, -0.003211085218936205, -0.03346966207027435, -0.020617779344320297, -0.000949258916079998, -0.005082524847239256, -0.005823181942105293, 0.028128111734986305, -0.00470707518979907, 0.0026898537762463093, -0.0015875287353992462, 0.01714530773460865, 0.003953450359404087, 0.007525317370891571, 0.00022026710212230682, 0.009036747738718987, 0.024084394797682762, -0.001073930412530899, 0.02551521547138691, 0.004745463840663433, 0.008457252755761147, -0.029851965606212616, 0.019985957071185112, -0.007217259146273136, 0.040403954684734344, 0.015828654170036316, -0.009936334565281868, -0.0025276353117078543, -0.007579674944281578, -0.00334223173558712, -0.028860049322247505, 0.041233621537685394, 0.009305317886173725, -0.017027128487825394, 0.005298387259244919, 0.03732991963624954, -0.025527315214276314, -0.02404056489467621, 0.014154328964650631, 0.014151781797409058, 0.0024121154565364122, 0.00912674143910408, -0.0014729899121448398, 0.026815589517354965, -0.0021127478685230017, -0.01530466042459011, -0.01669931598007679, 0.02190081775188446, -0.009798863902688026, 0.012604610994458199, 0.01806541718542576, -0.05091986805200577, 0.031843192875385284, -0.021130822598934174, -0.009717724286019802, -0.019831039011478424, 0.02539323829114437, -0.008842622861266136, 0.001740194857120514, 0.010272271931171417, -0.020476937294006348, 0.020468246191740036, 0.020754728466272354, -0.020427672192454338, 0.01689993590116501, -0.027141787111759186, -0.008447160013020039, -0.029830768704414368, 0.0351046584546566, -0.01487876195460558, 0.010475631803274155, 0.007520025596022606, 0.027107931673526764, -0.016778279095888138, 0.016087934374809265, 0.013497838750481606, -0.009703639894723892, -0.04019097238779068, 0.0037689926102757454, 0.013631396926939487, 0.015639392659068108, 0.02434571087360382, 0.0007969094440340996, 0.02704095095396042, 0.01530000101774931, -0.014958949759602547, -0.01110790390521288, -0.08026932924985886, -0.004455074667930603, 0.013439539819955826, -0.03481336683034897, 0.007716871332377195, -0.026653356850147247, -0.010997072793543339, 0.027251306921243668, -0.008205123245716095, -0.043947093188762665, -0.023148739710450172, 0.027871713042259216, -0.010274404659867287, 0.027518849819898605, 0.01716666854918003, -0.0030816993676126003, 0.006603289395570755, 0.010345938615500927, -0.01186707429587841, -0.02551102638244629, -0.010528136044740677, -0.017055977135896683, 0.028042936697602272, 0.027707017958164215, -0.013662295415997505, 0.03798600286245346, 0.002203589305281639, -0.03508687764406204, -0.02291925624012947, -0.0019763680174946785, 0.00218871608376503, -0.023191232234239578, 0.01355411484837532, -0.025977373123168945, 0.02188873291015625, -0.016574976965785027, -0.0165125522762537, 0.0070700207725167274, 0.005298753269016743, 0.013621687889099121, -0.02038509026169777, 0.009657980874180794, 0.04321931302547455, -0.003138818545266986, 0.004450850188732147, 0.04059887304902077, 0.020879752933979034, 0.02257467806339264, 0.017142662778496742, -0.028299879282712936, 0.010118874721229076, 0.01681477576494217, -0.026487408205866814, 0.020697781816124916, -0.023137927055358887, 0.005542243365198374, -0.019593212753534317, 0.027735881507396698, -0.0006269637960940599, -0.022540194913744926, -0.006535104475915432, -0.028215698897838593, 0.0007828313391655684, 0.011322440579533577, 0.003850656095892191, 0.0018057833658531308, 0.01066641230136156, -0.010125799104571342, -0.022752465680241585, 0.03508520498871803, -0.01003092061728239, -0.0252869613468647, -0.02538173459470272, -0.017332682386040688, -0.02490924298763275, 0.000688306987285614, -0.016260800883173943, -0.005586829036474228, -0.008817574940621853, 0.006786915473639965, 0.006052155513316393, 0.0011830348521471024, -0.01901598647236824, -0.016968853771686554, 0.004539707209914923, 0.016283610835671425, 0.015106556005775928, 0.03927351534366608, 0.021897027269005775, -0.02380063757300377, 0.04216799885034561, 0.02839617058634758, 0.022542517632246017, 0.018130730837583542, -0.018215009942650795, -0.009252851828932762, 0.0065346998162567616, -0.012016236782073975, 0.0163472481071949, 0.00969895999878645, -0.030441470444202423, -0.016312478110194206, 0.028362097218632698, -0.011556986719369888, 0.013223247602581978, 0.01706187054514885, -0.009818985126912594, 0.004372978582978249, -0.026884548366069794, 0.00045512395445257425, 0.0029196434188634157, 0.012527862563729286, -0.002426714636385441, 0.012573442421853542, 0.014615429565310478, -0.0036426151636987925, -0.002187446691095829, -0.03224746882915497, 0.07132658362388611, 0.01901588775217533, 0.018382839858531952, -0.018809005618095398, -0.025321289896965027, -0.04524986073374748, -0.013249257579445839, 0.006610242649912834, -0.038895390927791595, 0.00595844816416502, 0.014188607223331928, -0.014057681895792484, 0.009408418089151382, 0.008338061161339283, -0.009238297119736671, 0.02095513790845871, -0.029777955263853073, 0.024773182347416878, 0.0018555913120508194, -0.006319817155599594, 0.01657581701874733, -0.013322265818715096, -0.0005319439806044102, -0.019354822114109993, 0.0011487652081996202, -0.019444655627012253, 0.04123436659574509, -0.017537906765937805, -0.015928855165839195, 0.014160754159092903, -0.034970492124557495, -0.008409454487264156, -0.00888183806091547, -0.005493363365530968, 0.010157211683690548, 0.004099629819393158, 0.01521451398730278, -0.0003173188306391239, 0.008004117757081985, -0.013966435566544533, -0.031091459095478058, -0.01796477660536766, -0.01687662862241268, 0.01765289157629013, -0.013308419845998287, 0.0009903321042656898, -0.00035492144525051117, -0.008208769373595715, -0.028259124606847763, 0.007530254777520895, -0.01963687315583229, -0.006258778739720583, 0.015156608074903488, 0.03127845376729965, -0.02688789926469326, -0.027740228921175003, -0.004721520468592644, -0.019696319475769997, -0.004693764261901379, 0.0014880560338497162, -0.02633797936141491, -0.00366260576993227, 0.005537723191082478, -0.011305497959256172, 0.020697513595223427, -0.02209668606519699, -0.011897261254489422, 0.0008000929374247789, -0.004306507296860218, -0.04293011873960495, 0.006241492927074432, -0.030348556116223335, -0.0018212306313216686, 0.00563591904938221, -0.05335179716348648, 0.051219407469034195, -0.018727056682109833, -0.013282055035233498, 0.0019839550368487835, -0.03781641274690628, -0.045049428939819336, -0.0011153407394886017, -0.01962076500058174, 0.0007462231442332268, 0.019465819001197815, 0.012239626608788967, -0.010156930424273014, -0.07392632961273193, -0.019028957933187485, -0.005368306301534176, -0.014665873721241951, 0.03825812041759491, 0.014603979885578156, -0.016074400395154953, -0.011172907426953316, -0.02536792866885662, -0.003085013013333082, -0.046355728060007095, -0.026684705168008804, 0.008142066188156605, 0.011876391246914864, 0.014970782212913036, -0.000053717754781246185, 0.003713324898853898, -0.009276313707232475, -0.031982190907001495, 0.017844274640083313, -0.009655056521296501, 0.009678731672465801, 0.0029029883444309235, 0.004422432277351618, -0.013770663179457188, -0.0800972729921341, -0.0005097824614495039, 0.0009065298363566399, -0.031086593866348267, -0.016472376883029938, -0.014396658167243004, 0.016198378056287766, -0.02110232785344124, -0.015070859342813492, -0.017690017819404602, -0.003464061999693513, -0.00009117834270000458, 0.02717442624270916, -0.023255979642271996, 0.03256918489933014, -0.01074683852493763, 0.02176082879304886, -0.018299205228686333, -0.011035682633519173, 0.04648970067501068, 0.005703897215425968, 0.023208443075418472, -0.007450061850249767, -0.01567256823182106, -0.015431872569024563, -0.010063675232231617, 0.00034946389496326447, 0.020969238132238388, -0.03933187574148178, -0.02939024567604065, 0.035793520510196686, -0.011436428874731064, -0.021105246618390083, -0.040310755372047424, -0.012958915904164314, -0.026736993342638016, -0.01572255976498127, -0.02661767229437828, -0.010347499512135983, -0.00014632614329457283, -0.004945342428982258, 0.027887806296348572, 0.028383247554302216, 0.013007445260882378, -0.011138979345560074, -0.01918291486799717, 0.012975342571735382, -0.01626514457166195, 0.008132954128086567, 0.012449603527784348, 0.006300352513790131, -0.0037536481395363808, 0.03420686721801758, -0.00407312111929059, -0.001923995092511177, -0.0067741042003035545, -0.010119711980223656, 0.001958746463060379, 0.017778338864445686, 0.00864099245518446, -0.018009919673204422, -0.011319629848003387, -0.010348377749323845, 0.0709913969039917, -0.023922599852085114, -0.01485336385667324, -0.022040946409106255, 0.016005845740437508, 0.006021792069077492, -0.06808410584926605, 0.0012319290544837713, -0.01758616603910923, -0.013627167791128159, -0.02594829350709915, -0.01245836541056633, -0.017160708084702492, 0.019914567470550537, 0.03241909295320511, -0.011607393622398376, 0.005155512131750584, 0.045783836394548416, -0.0010077310726046562, 0.036239370703697205, 0.04432693123817444, 0.016010986641049385, -0.007918452844023705, 0.02178352326154709, -0.007110994774848223, -0.006709357723593712, 0.010879142209887505, 0.013235338032245636, -0.03408364951610565, 0.015735425055027008, -0.0036759432405233383, -0.00031438469886779785, 0.004597033374011517, 0.011146996170282364, 0.022168010473251343, 0.02763121947646141, -0.017854737117886543, 0.017548061907291412, 0.0015679532662034035, -0.007540352642536163, 0.006907247938215733, -0.015910902991890907, -0.0009114358108490705, -0.004751260858029127, 0.03837859630584717, -0.02799374610185623, -0.011718371883034706, -0.03170114755630493, -0.0006775623187422752, 0.006152399815618992, 0.020344235002994537, 0.0032758915331214666, 0.019672218710184097, -0.03337688371539116, 0.024362744763493538, 0.04616734758019447, -0.022491006180644035, 0.03375443443655968, -0.03149113804101944, 0.011808210052549839, 0.014870397746562958, -0.023391278460621834, 0.05520196631550789, -0.025441449135541916, 0.03126823157072067, -0.022918015718460083, 0.011590278707444668, -0.022292010486125946, -0.015613120049238205, 0.02353043295443058, -0.013361403718590736, 0.012282932177186012, 0.0166013240814209, -0.04266812279820442, 0.03377909958362579, -0.013868739828467369, 0.020094476640224457, 0.0013308045454323292, 0.008156215772032738, 0.0038535965140908957, -0.005958043970167637, -0.01931186392903328, -0.00009736837819218636, -0.012424884364008904, -0.00759473443031311, 0.01784507930278778, 0.006301421672105789, -0.004513413645327091, -0.004135297145694494, 0.0037573319859802723, 0.04576202109456062, 0.013671868480741978, 0.0030673942528665066, 0.0201900415122509, 0.007774419151246548, 0.035217925906181335, 0.003100457601249218, 0.003647573757916689, 0.005980256013572216, 0.017948273569345474, 0.002666147891432047, -0.03041166067123413, -0.014279317110776901, 0.029111329466104507, -0.04092102870345116, 0.0021075429394841194, 0.005385343451052904, -0.005456016398966312, -0.00871602725237608, -0.01777198538184166, -0.02156864106655121, -0.0081211868673563, 0.02888687327504158, -0.007173413876444101, 0.0021094621624797583, 0.030464619398117065, -0.014769398607313633, -0.024796100333333015, 0.01334939245134592, -0.013536183163523674, -0.012192841619253159, 0.023336216807365417, 0.020457658916711807, 0.025154320523142815, 0.008555926382541656, -0.004619214218109846, -0.002904482651501894, -0.006200673058629036, -0.04351033270359039, 0.02958841621875763, 0.014520022086799145, -0.054691992700099945, -0.004021599888801575, 0.015677740797400475, -0.0023128711618483067, 0.013025417923927307, -0.006935132667422295, 0.017707981169223785, -0.010383397340774536, -0.03523586690425873, -0.004555094987154007, -0.0004209491889923811, 0.008111312985420227, -0.010816223919391632, 0.011946205049753189, -0.01231554988771677, 0.01169588603079319, 0.004159200470894575, 0.02006983384490013, 0.006966424640268087, -0.0032014353200793266, 0.0131774777546525, -0.016598891466856003, -0.008015144616365433, -0.004099672194570303, 0.005654980428516865, 0.010668548755347729, 0.016955047845840454, -0.007929452694952488, 0.014790888875722885, 0.001107858493924141, -0.028878264129161835, -0.026710540056228638, -0.02596069872379303, 0.0007751956582069397, 0.007516259793192148, 0.026539253070950508, 0.0032035086769610643, -0.011197065934538841, 0.0012728655710816383, 0.009988942183554173, -0.01765364594757557, -0.01388472504913807, 0.028470996767282486, -0.016908563673496246, -0.018419016152620316, -0.016730189323425293, -0.01467973180115223, 0.015146775171160698, -0.014066958799958229, 0.012544550001621246, 0.03147662431001663, 0.009683215990662575, -0.016163576394319534, -0.006343620829284191, -0.010313224978744984, -0.0012659367639571428, -0.006218929309397936, 0.012629691511392593, 0.002202569507062435, 0.009575851261615753, -0.0028440477326512337, -0.020340345799922943, 0.009082771837711334, 0.013549908064305782, 0.017301570624113083, -0.013221561908721924, 0.02850528433918953, -0.0016037304885685444, -0.010884535498917103, -0.02224413864314556, -0.008071104064583778 ]
[ -0.3556939959526062, 0.0321308970451355, 0.10135683417320251, 0.315895676612854, 0.20957177877426147, 0.30075621604919434, -0.037912510335445404, 0.034351300448179245, -0.5840374827384949, -0.4858769476413727, -0.052006568759679794, -0.1265014111995697, -0.0637553408741951, 0.12651066482067108, -0.3714410662651062, 0.7594315409660339, 0.5166970491409302, 0.5428752899169922, -0.6775001287460327, -0.6833887696266174, -0.24148370325565338, -0.8405324220657349, 0.6003289818763733, -0.04690330848097801, -0.19227224588394165, 0.0032100628595799208, 0.63972407579422, 0.007926061749458313, 0.5782358646392822, 0.13098856806755066, -0.35087987780570984, 0.5838638544082642, 0.5887991189956665, -0.3705956041812897, -0.39304083585739136, 0.1768755316734314, -0.4583720564842224, 0.023630894720554352, 0.26000267267227173, 0.14486496150493622, -0.11103356629610062, -0.3836519718170166, -0.6095221638679504, 0.47569888830184937, 0.3111073076725006, -0.44038528203964233, -0.9369162321090698, 0.5274685621261597, 0.09470683336257935, -0.14857231080532074, -0.13222599029541016, -0.054051801562309265, 0.14066699147224426, 0.16627538204193115, 0.08210629969835281, 0.034808821976184845, -0.7884066700935364, 0.0013391049578785896, 0.23812450468540192, -0.11541495472192764, -0.274945467710495, 0.12088965624570847, -0.030211854726076126, 0.008225394412875175, -0.34047695994377136, 0.7531210780143738, 0.1538051813840866, 0.1675529032945633, -0.5432218313217163, -0.12713725864887238, 0.397712767124176, -0.16582849621772766, 0.021843887865543365, 0.2107866406440735, 0.5762841701507568, 0.287126362323761, -0.3179876506328583, -0.3859221339225769, 0.3053865432739258, 0.027522390708327293, -0.1260647475719452, 0.12054533511400223, 0.5411427617073059, 0.3062140643596649, 0.4098716378211975, 0.20237566530704498, -0.050985708832740784, 0.6809301972389221, -0.29057973623275757, 0.16285467147827148, -0.18294137716293335, 0.11235497891902924, 0.7069545388221741, 0.2861345708370209, 0.5146299600601196, 0.6064510941505432, 0.02189461886882782, 0.4224761426448822, 0.13644054532051086, -0.009029868990182877, -0.05718964338302612, 0.37289851903915405, -0.20784828066825867, -0.5973837375640869, -0.6065555214881897, -0.6347307562828064, 0.13472120463848114, -0.7468883395195007, -0.6897432208061218, 0.07962718605995178, -1.0208297967910767, -0.09190868586301804, -0.2591122090816498, -0.07441677153110504, -0.21180817484855652, 0.41124874353408813, 0.11137159168720245, -0.9833330512046814, -0.2151503711938858, -0.29664790630340576, -0.5314364433288574, 0.9647945165634155, -0.32061395049095154, 0.5618013143539429, 0.2994445264339447, 0.3288416862487793, 0.21273618936538696, 0.058544229716062546, 0.0467367060482502, 0.5733927488327026, 0.495105117559433, 0.8928381204605103, -0.21761639416217804, -0.22690266370773315, 0.27591606974601746, 0.14649821817874908, 0.09838230907917023, 0.15369480848312378, 0.2540658116340637, -0.1112380176782608, -0.5555792450904846, -0.22942295670509338, -0.1014413833618164, 0.36645859479904175, -0.0656263455748558, -0.04345429316163063, -0.4157055914402008, 0.002162972465157509, -0.3626384437084198, -0.5757829546928406, 0.0904037207365036, -0.6092939972877502, -0.21694794297218323, -0.11662975698709488, -0.04383141174912453, 0.46513479948043823, -0.06135380268096924, -0.4131889343261719, 0.35497015714645386, 0.33322808146476746, 0.43113085627555847, -0.19016321003437042, -0.6615709662437439, -0.13612742722034454, 0.5725748538970947, 0.23808728158473969, -0.07381543517112732, 0.2611887753009796, -0.16345328092575073, 0.15457683801651, -0.22476036846637726, -0.24691590666770935, -0.05058436468243599, -0.6763419508934021, -0.09952590614557266, -0.37746793031692505, -0.028681732714176178, 0.3619130253791809, 0.12394848465919495, -0.29484859108924866, -0.8249295353889465, -0.3462044596672058, -0.019368965178728104, -0.536498486995697, 0.5244262218475342, 0.2572762966156006, 0.09926322847604752, 0.3198190927505493, 0.015326960012316704, -0.02360832877457142, -0.3927854299545288, -0.31158021092414856, 0.9353272318840027, -0.14702032506465912, 1.3337976932525635, 0.1572009176015854, 0.07402730733156204, 1.304229736328125, 0.6279353499412537, 0.2630098760128021, -0.050159383565187454, -0.06729210913181305, 0.24315573275089264, 0.4074415862560272, -0.832155704498291, 0.04528801515698433, -0.4818410873413086, -0.12100369483232498, -0.0888449102640152, 0.1223844587802887, 0.38296255469322205, -0.3986946940422058, -0.19354714453220367, 0.4041191339492798, 0.0019034807337448, -0.14219948649406433, 0.6195230484008789, -0.4011269211769104, -0.41811418533325195, -0.057859525084495544, 0.39276590943336487, -0.7685768008232117, 0.7836322784423828, 0.42388659715652466, 0.060232944786548615, 1.1107243299484253, 0.5696950554847717, 0.3226049244403839, 0.853068470954895, 0.08561614155769348, -0.08159177005290985, -0.2303694188594818, 0.573672354221344, -0.3490026891231537, 0.13630853593349457, 0.01672673225402832, 0.0013994559412822127, -0.6057334542274475, -0.043554626405239105, -0.07621365785598755, -0.4041236340999603, 0.9291370511054993, -0.2854297459125519, -0.31573429703712463, 0.41581791639328003, 0.00906682014465332, -0.5255411863327026, 0.20640355348587036, -0.844822347164154, -0.07087818533182144, -0.39452630281448364, 0.47775861620903015, -0.001721560605801642, -0.456525057554245, -0.013410759158432484, 0.38172709941864014, -0.26298630237579346, -0.33446747064590454, -0.17132636904716492, -0.3935472071170807, 0.023623071610927582, 0.2717517912387848, 0.24704493582248688, 0.3519282937049866, -0.5132486820220947, -1.0734426975250244, -0.5390475392341614, -0.11061449348926544, 0.8007467985153198, 0.9094535708427429, 0.7458986639976501, -0.03676480054855347, -1.0861914157867432, -0.19367919862270355, 0.25011810660362244, -0.5196394324302673, -0.323400616645813, 0.7829545140266418, -0.4244384467601776, -0.48496946692466736, 0.0914665162563324, 0.4799136221408844, 1.239391565322876, -0.001190629554912448, -0.35861364006996155, 0.42335233092308044, -0.3298127055168152, -0.2289275974035263, -0.6255654692649841, -0.7976088523864746, 0.06465689092874527, 0.3938627243041992, 0.08175092935562134, 0.1566196084022522, 0.14866986870765686, 0.3183572292327881, 0.10652840882539749, 0.4760377109050751, 0.8330292105674744, 0.16907641291618347, -0.4409070611000061, 0.04370749741792679, -0.04402918368577957, -0.1192970871925354, -0.12495961785316467, 0.4138447344303131, -0.2037607729434967, 0.11141803860664368, -5.64033842086792, -0.16936908662319183, -0.4094330966472626, -0.589659571647644, -0.1791754961013794, -0.29546669125556946, 0.8547789454460144, -0.45992186665534973, 0.20645961165428162, 0.46328890323638916, 0.41614869236946106, 0.7382379770278931, 0.18056435883045197, -0.5176395773887634, -0.39507898688316345, -0.3617708384990692, -0.151414155960083, -0.14980319142341614, 0.6906583905220032, -0.7358006238937378, 0.40015196800231934, -0.4814128279685974, -0.444015771150589, 0.6001380085945129, -0.056001968681812286, 0.6731889843940735, -0.5490323305130005, -0.2974957823753357, -0.656113862991333, -0.6903142333030701, -0.0067715952172875404, -0.29049453139305115, -0.269955039024353, 0.27605921030044556, 0.039973899722099304, 0.1395585536956787, 0.3030287027359009, 0.2105664610862732, -0.03604462742805481, -0.3334343135356903, 0.19853141903877258, -0.31581738591194153, -0.1728135645389557, -0.18521474301815033, 0.0893046110868454, 0.24091720581054688, -0.09590534120798111, 0.049523066729307175, -0.14452829957008362, 0.6570515036582947, 0.2875843942165375, -0.3397260010242462, 0.2870083451271057, 0.909010648727417, 0.5218954086303711, 0.2647879123687744, -0.02315179817378521, -0.031694769859313965, -0.6399146318435669, 0.006206474266946316, 0.255148708820343, 0.42210257053375244, -0.554161012172699, -1.1415826082229614, 0.013351723551750183, -0.029355566948652267, -0.7137430310249329, -0.3212888538837433, 0.49262040853500366, -0.2402489334344864, -0.3115977644920349, 0.06159976124763489, 0.4002636969089508, -0.6976534128189087, 0.3966873586177826, -0.4452803432941437, -0.32119020819664, 0.0917242020368576, -0.47581204771995544, -0.5723789930343628, -0.2581731379032135, -0.4382714629173279, -0.205488383769989, 0.021797973662614822, 0.17879126965999603, -0.27973535656929016, -0.29037684202194214, 0.1648080199956894, 0.20193122327327728, 0.25013890862464905, 0.17776666581630707, 0.10775862634181976, 0.03467757999897003, 0.7566977143287659, 0.10880065709352493, 0.5924134254455566, 0.36622101068496704, 0.9619658589363098, 0.2626774311065674, 0.09347724914550781, 0.21515309810638428, -0.5259485840797424, -0.4572732150554657, -0.5202993750572205, -0.4339880347251892, 0.46184873580932617, -0.5207667350769043, -0.2561975121498108, 0.5730900764465332, -0.8088607788085938, 0.5384775400161743, -0.37195995450019836, -0.3852076530456543, -0.20459751784801483, 0.6972866654396057, -0.35078001022338867, -0.2152366042137146, 0.3946726620197296, 0.3328917622566223, 0.060524482280015945, 0.22663860023021698, 0.24213671684265137, -0.8327430486679077, 0.4008674621582031, -0.21495956182479858, -0.439097136259079, 0.18953917920589447, 0.303219199180603, -0.6702558994293213, 0.15547190606594086, 0.283551424741745, 0.37695392966270447, -0.05285104364156723, -0.11479581147432327, 0.18095406889915466, -0.4520689845085144, -0.6408213376998901, 0.278358519077301, 0.5125775933265686, 0.3305879533290863, 0.01905648782849312, 0.01667439006268978, -0.006341265048831701, 0.17867563664913177, -0.16018199920654297, -0.08040125668048859, 0.058855265378952026, -0.2873650789260864, -0.39968544244766235, -0.2503804564476013, 0.1495126485824585, -0.5973623394966125, 0.27034980058670044, 0.5986678004264832, -0.19342009723186493, 0.21027761697769165, 0.26113978028297424, 0.3809313476085663, 0.0818701907992363, -0.4242393970489502, -0.27734142541885376, -0.09921462088823318, -0.6668652892112732, 0.016578348353505135, 0.11501552164554596, -0.5571473240852356, 0.22706930339336395, -0.3760957717895508, -0.07731375843286514, 0.1550304889678955, -0.17260180413722992, -0.48815274238586426, 0.40058937668800354, 0.08342999219894409, 0.20903533697128296, -0.16541683673858643, -0.03446272760629654, -0.3394843637943268, -0.3233017027378082, 0.5480303168296814, -0.1616089791059494, -0.216182678937912, -0.020477693527936935, 0.27787378430366516, 0.4207601845264435, 0.41195809841156006, -0.0444914735853672, -0.4363993704319, -0.2069910615682602, -0.5117473602294922, 0.34606483578681946, -0.0008986949687823653, 0.19003118574619293, -0.005683694500476122, 0.22153370082378387, 0.20832328498363495, 0.21248161792755127, 0.16991940140724182, 0.4663923978805542, -0.3324989080429077, 0.021598052233457565, 0.5954039096832275, -0.23027607798576355, 0.5136411786079407, 0.45650094747543335, -0.41128402948379517, -0.11598145961761475, 0.17855921387672424, -0.7378149032592773, -0.31457680463790894, -0.18451499938964844, -0.5508455634117126, 0.1403633952140808, 0.10998447984457016, 0.18206283450126648, -0.06644804775714874, 0.3675871789455414, -0.6161959171295166, -0.2777094841003418, 0.8730356693267822, 0.035284388810396194, -0.12042368203401566, -0.21780569851398468, -0.2478138655424118, -0.5848231911659241, 0.40961572527885437, 0.3606503903865814, -0.6733335256576538, 0.24198952317237854, -0.33979225158691406, -0.10936558246612549, -0.5082727670669556, 0.3505069613456726, -0.051995959132909775, -0.14995138347148895, -0.6140185594558716, -0.15636834502220154, 0.06997691094875336, 0.3191673755645752, 0.2257736623287201, 0.3021278977394104, 0.3796241581439972, -0.39696425199508667, -0.3950573801994324, -0.33030280470848083, -0.28381696343421936, 0.6251762509346008, -0.9684118628501892, -0.03865864872932434, 0.6085343360900879, 0.345607727766037, -0.6306464076042175, 0.30602017045021057, 0.23606820404529572, 1.104738712310791, 0.5330507159233093, -0.6029589772224426, -1.0065693855285645, -0.2995710074901581, -0.12884116172790527, -0.13212350010871887, 0.10392904281616211, -0.46865421533584595, 0.22048228979110718, 0.09838076680898666, 0.2730018198490143, 0.022850170731544495, -0.6034775376319885, 0.2758847177028656, -0.15134255588054657, -0.11917511373758316, 0.038843121379613876, 0.6804477572441101, 0.04908197373151779, -0.27709782123565674, 0.4872300922870636, -0.3354787826538086, 0.17037197947502136, -0.29248350858688354, 0.1553289145231247, -0.13382577896118164, -0.3857521414756775, 0.4582901895046234, -0.14781025052070618, 0.0277660321444273, -0.46291616559028625, 0.09642712771892548, -0.6549081802368164, 0.17020903527736664, -0.2587195038795471, -0.4429253339767456, 0.26361966133117676, -0.7078994512557983, -0.16107164323329926, 0.19544869661331177, 0.4389781653881073, 0.09723259508609772, 0.23864224553108215, -0.4069356918334961, 0.0738057866692543, -0.39939096570014954, 0.5159389972686768, 0.3439196050167084, -0.22822493314743042, 0.22925685346126556, 0.3960292637348175, 0.043031178414821625, -0.07439075410366058, -0.3745644688606262, 0.08837655931711197, 0.1003078818321228, -0.0935128927230835, 0.6071673631668091, 0.051643311977386475, -0.3807715177536011, 0.051276735961437225, -0.40714192390441895, -0.040282655507326126, -0.050945937633514404, 0.25890490412712097, 0.6308536529541016, 0.8035982847213745, 0.8324058055877686, -0.06471637636423111, -0.4368817210197449, 0.4766746461391449, 0.22638919949531555, -0.11500030010938644, 0.43516185879707336, 1.031641960144043, 0.5833678245544434, 0.32346048951148987, 0.16947288811206818, 0.8110281825065613, 0.4780515134334564, 0.4154803156852722, 0.031350310891866684, -0.14942926168441772, -0.3222286105155945, -0.10128253698348999, 0.6545144319534302, 0.23333409428596497, -0.24324406683444977, -0.37776535749435425, 0.41657522320747375, 0.20336154103279114, 0.21369437873363495, 0.05484892800450325, 0.7910954356193542, -0.29195263981819153, 0.20606708526611328, -0.36051610112190247, -0.8302943110466003, 0.33072933554649353, -0.3415311574935913, 0.058012425899505615, 0.3638705313205719, -0.35091114044189453, -0.8746077418327332, 0.6420390009880066, -0.28754040598869324, -0.22019453346729279, 0.039866041392087936, 0.6854729056358337, 0.13785408437252045, -0.6085505485534668, 0.4233873188495636, 0.7803102135658264, 0.20894838869571686, -0.18049542605876923, 0.09081131219863892, -0.34228846430778503, -0.31871193647384644, 0.33634302020072937, 0.06946340203285217, 0.1924869865179062, 0.1869957596063614, -0.212624192237854, -0.31726425886154175, 0.6704838275909424, -0.26845502853393555, -0.013668214902281761, -0.1510801613330841, -0.51666259765625, -0.006681967992335558, -0.3098161518573761, -0.2166307419538498, 0.04863066226243973, 0.09339441359043121, -0.21556247770786285, 0.622563898563385, -0.5145564079284668, 0.16512982547283173, 0.3157411813735962, 0.16078495979309082, -0.050531595945358276, -0.20597635209560394, 0.04974106699228287, 0.4614139199256897, 0.4096710681915283, -0.4669465720653534, -0.12858568131923676, -0.045720022171735764, 0.5587196946144104, -0.566368579864502, 0.30414411425590515, -0.5750629901885986, -0.23164640367031097, -0.809597373008728, -0.23726561665534973, 0.8574017882347107, 0.8845520615577698, -0.2783316969871521, 0.2534996271133423, 0.02145424112677574, 0.1872604638338089, 0.5048958659172058, -0.557023286819458, -0.2174636423587799, -0.6697083115577698, -0.15153911709785461, -0.8930407166481018, 0.9514439105987549, -0.10168395936489105, -0.2561854422092438, -0.0830639898777008, 0.3083883821964264, 0.2246907502412796, -0.1481199413537979, 0.19744643568992615, -0.47923052310943604, 0.15635910630226135, -0.20259277522563934, 0.183588445186615, -0.7182703018188477, 0.1771797388792038, -0.2085014432668686, 0.3138114809989929, 0.20787739753723145, -0.42675140500068665, 0.027339180931448936, -1.012807846069336, -0.27373406291007996, 0.07582027465105057, 0.14172685146331787, 0.2867737114429474, -0.33195528388023376, -0.3873089551925659, -0.9119110107421875, -0.1990363448858261, -0.04671849310398102, -0.059016842395067215, -0.054193973541259766, -0.21670904755592346, 0.09898211807012558, -0.08472328633069992, -0.18311280012130737, -0.4156193733215332, 0.061811190098524094, 0.08590348064899445 ]
To elucidate the transcriptional 'landscape' that regulates human lymphoid commitment during postnatal life, we used RNA sequencing to assemble the long non-coding transcriptome across human bone marrow and thymic progenitor cells spanning the earliest stages of B lymphoid and T lymphoid specification. Over 3,000 genes encoding previously unknown long non-coding RNAs (lncRNAs) were revealed through the analysis of these rare populations. Lymphoid commitment was characterized by lncRNA expression patterns that were highly stage specific and were more lineage specific than those of protein-coding genes. Protein-coding genes co-expressed with neighboring lncRNA genes showed enrichment for ontologies related to lymphoid differentiation. The exquisite cell-type specificity of global lncRNA expression patterns independently revealed new developmental relationships among the earliest progenitor cells in the human bone marrow and thymus.
[ 0.01762598380446434, 0.008678041398525238, -0.01604003831744194, 0.002350536407902837, 0.00046363286674022675, -0.00783624779433012, 0.013877380639314651, 0.00790091510862112, -0.016913175582885742, 0.005575962830334902, -0.00764928525313735, 0.007989718578755856, -0.0006041087908670306, 0.015262958593666553, -0.004249587655067444, 0.02156693860888481, -0.03177885711193085, -0.02707608789205551, 0.019665831699967384, 0.018434517085552216, -0.00523283751681447, -0.04350610077381134, 0.011796031147241592, 0.026852265000343323, 0.040157169103622437, -0.0015327592846006155, -0.01210840605199337, 0.008359644562005997, 0.013092096894979477, 0.0036970246583223343, 0.004425779916346073, 0.0185677669942379, 0.02171497792005539, 0.028267383575439453, 0.005797409452497959, -0.009355120360851288, -0.001534662558697164, 0.029291333630681038, 0.053466830402612686, -0.00607483834028244, 0.031899258494377136, -0.016317293047904968, 0.0045204381458461285, -0.0021078798454254866, -0.010232357308268547, -0.0315597802400589, -0.009190471842885017, 0.012660445645451546, -0.0017947275191545486, 0.01518956758081913, -0.012373872101306915, -0.012124324217438698, -0.015369690023362637, 0.03776603192090988, -0.007832497358322144, 0.00875802244991064, 0.023369401693344116, 0.001161438412964344, -0.03439698740839958, 0.016010496765375137, 0.0015993532724678516, 0.016914771869778633, 0.015699902549386024, -0.008334526792168617, 0.014251291751861572, -0.06596790999174118, 0.025585820898413658, 0.0032382772769778967, -0.02836432494223118, -0.0009860135614871979, 0.003829912981018424, 0.012657564133405685, -0.014169719070196152, -0.004212706349790096, 0.018802637234330177, -0.018096962943673134, -0.0063955457881093025, -0.0288332961499691, 0.026226099580526352, 0.0309391338378191, -0.010132651776075363, -0.018966495990753174, 0.0073070828802883625, 0.018117420375347137, 0.010560201480984688, -0.013914498500525951, -0.034093476831912994, 0.0005973444785922766, 0.013613127171993256, -0.013909189961850643, 0.03473382443189621, 0.01908799633383751, -0.030926499515771866, 0.019945118576288223, -0.016390042379498482, 0.004214281216263771, 0.004286385141313076, -0.013913571834564209, 0.042650893330574036, -0.004339240025728941, -0.01972375437617302, 0.016845783218741417, 0.02398793026804924, 0.002465619705617428, -0.027192946523427963, 0.009816370904445648, -0.0022125476971268654, 0.022439926862716675, -0.016153497621417046, 0.007434141356498003, -0.006696167401969433, 0.012446131557226181, -0.015406699851155281, 0.015541239641606808, 0.02190689742565155, 0.0037927506491541862, 0.000715659698471427, -0.003245217725634575, 0.015817660838365555, -0.006582789123058319, -0.016032053157687187, 0.014210306107997894, -0.0005780227947980165, -0.005478492006659508, 0.005360707640647888, 0.014777721837162971, -0.003441678360104561, -0.008135033771395683, -0.0014088978059589863, 0.02542663924396038, -0.008233767002820969, 0.020603874698281288, -0.062234584242105484, -0.003280024975538254, -0.01398848369717598, -0.0030016708187758923, 0.0013864070642739534, 0.014069609344005585, -0.001001567579805851, -0.008112424053251743, 0.027390044182538986, 0.0045210751704871655, -0.0016835686983540654, 0.012334258295595646, 0.02443082258105278, 0.008777735754847527, -0.00799613818526268, 0.0016106130788102746, 0.009958947077393532, -0.03532785922288895, -0.0007378486916422844, 0.0027889683842658997, 0.015691330656409264, -0.02802564762532711, 0.01251788530498743, 0.017059670761227608, -0.02778729423880577, -0.03609137237071991, -0.004171723499894142, 0.015009218826889992, 0.0020744046196341515, 0.01711154915392399, 0.014038510620594025, 0.011692564934492111, 0.03043653815984726, -0.010946173220872879, -0.012617755681276321, 0.004428197164088488, -0.00621581356972456, 0.006105516105890274, 0.0007401054608635604, -0.012380671687424183, -0.010449466295540333, 0.010756032541394234, -0.00906696729362011, -0.00812201015651226, -0.0038079749792814255, 0.009617780335247517, -0.01580168679356575, 0.06583613902330399, -0.008771184831857681, 0.03798376023769379, -0.01751498505473137, -0.006745731458067894, 0.011970477178692818, -0.009925306774675846, 0.0008249711245298386, 0.0012954816920682788, -0.02088332362473011, -0.011946473270654678, 0.04190817475318909, -0.013567168265581131, -0.023121722042560577, 0.01155519112944603, 0.001671905629336834, 0.003201519139111042, -0.005783550441265106, 0.007504183333367109, -0.008588762953877449, 0.002210104139521718, 0.01438947208225727, 0.004680880345404148, 0.01653135009109974, -0.033605676144361496, 0.006689185276627541, 0.00012222654186189175, 0.03234776854515076, -0.01485371869057417, -0.014637296088039875, -0.007365206256508827, 0.04520910233259201, 0.005698761437088251, -0.005167169496417046, -0.013882601633667946, -0.004402787424623966, 0.010586914606392384, -0.022656869143247604, 0.031702980399131775, 0.012178709730505943, -0.014744747430086136, 0.0035561085678637028, 0.0014885681448504329, 0.012419868260622025, -0.03716525062918663, 0.016684336587786674, -0.005779176019132137, 0.007522438652813435, 0.013395601883530617, -0.003514740616083145, -0.00828098226338625, 0.003144555725157261, -0.04754137247800827, -0.01278722658753395, 0.018792511895298958, 0.005141373723745346, 0.006967421621084213, 0.011967719532549381, -0.02964339591562748, 0.008747112937271595, -0.007806813344359398, -0.017289146780967712, -0.02009172923862934, -0.025462020188570023, -0.02105981484055519, -0.01790720783174038, -0.02272687666118145, -0.005343845579773188, 0.019223518669605255, -0.007632873952388763, -0.0248150322586298, 0.012084158137440681, -0.03712689131498337, 0.008646202273666859, 0.02729659527540207, 0.0028780335560441017, -0.00008848728612065315, 0.009670548141002655, -0.015178985893726349, 0.029379665851593018, -0.0072195325046777725, -0.00044616241939365864, 0.004540802910923958, 0.010473194532096386, -0.028856733813881874, -0.020972423255443573, -0.014787960797548294, 0.014096134342253208, 0.024632886052131653, -0.011380024254322052, -0.0110370684415102, 0.015511084347963333, -0.01824132539331913, 0.00683762738481164, -0.08088210225105286, -0.008689728565514088, -0.006799561902880669, 0.007216192781925201, 0.004582238383591175, 0.0024081694427877665, -0.011599021963775158, 0.020101767033338547, 0.002703348407521844, -0.031167183071374893, -0.0035362173803150654, 0.023175586014986038, -0.02096010372042656, 0.0030648503452539444, -0.01078328862786293, -0.01758848875761032, 0.010390887968242168, -0.013001513667404652, -0.031679775565862656, -0.03747827559709549, -0.023203710094094276, -0.024394182488322258, 0.013466183096170425, -0.0006262368988245726, -0.03487030044198036, 0.03047102689743042, -0.0005198883009143174, -0.0027490491047501564, 0.003378253895789385, 0.006286781281232834, -0.02252037078142166, -0.010029182769358158, 0.005901274271309376, -0.0020730053074657917, 0.013012592680752277, 0.001118851825594902, -0.004345874302089214, 0.014248304069042206, -0.009441083297133446, 0.027513962239027023, 0.00784815102815628, 0.0038268864154815674, -0.008581575937569141, -0.0046224938705563545, 0.007293366827070713, 0.03290724754333496, -0.0022412335965782404, 0.005620312876999378, 0.024057656526565552, -0.011603785678744316, 0.010294703766703606, 0.010993324220180511, 0.015329770743846893, 0.011459983885288239, -0.019571920856833458, 0.0032988640014082193, 0.0033988370560109615, 0.016958555206656456, -0.01519048772752285, -0.004328528884798288, 0.020844515413045883, -0.005807345733046532, 0.028711602091789246, -0.00399352191016078, 0.021031547337770462, 0.012764904648065567, 0.014386224560439587, -0.014793735928833485, -0.010908415541052818, 0.02232629619538784, -0.01420652586966753, -0.012939682230353355, -0.0011485754512250423, -0.01241285353899002, -0.04978566989302635, -0.010042224079370499, -0.013615189120173454, 0.005961082875728607, -0.0017904890701174736, 0.006321117281913757, 0.013892877846956253, 0.009660763666033745, -0.005602724850177765, 0.005741271656006575, -0.015744809061288834, -0.01838996447622776, 0.01136593334376812, 0.01618065871298313, 0.014726266264915466, -0.01884518191218376, 0.024775225669145584, 0.0334663912653923, 0.00961864460259676, 0.010319883935153484, -0.03422079235315323, -0.015238819643855095, 0.0034647320862859488, 0.010100097395479679, 0.004904426168650389, 0.010074141435325146, -0.053683385252952576, 0.003953037783503532, 0.024382393807172775, -0.015056993812322617, -0.015276072546839714, 0.014385792426764965, -0.0025473618879914284, -0.0033894272055476904, 0.0013992940075695515, -0.0003071647952310741, -0.00288778985850513, 0.016589876264333725, -0.012639597058296204, 0.024326151236891747, 0.011947445571422577, 0.026404963806271553, -0.0008420310914516449, 0.0074921767227351665, 0.07052204012870789, 0.016181670129299164, -0.009490001946687698, -0.031329963356256485, -0.03412366658449173, -0.019141322001814842, 0.0023457705974578857, 0.005721760913729668, -0.037231966853141785, -0.0034212088212370872, 0.016610920429229736, -0.018005942925810814, -0.0020836936309933662, 0.009436980821192265, -0.010119540616869926, -0.022463001310825348, -0.022455740720033646, 0.011975795030593872, 0.0017040418460965157, -0.0036026956513524055, 0.001511612324975431, 0.009756509214639664, -0.007609446067363024, -0.01892814412713051, -0.008904466405510902, -0.00598368514329195, 0.030724013224244118, -0.014461679384112358, -0.025502510368824005, 0.013947183266282082, 0.023066677153110504, -0.036380574107170105, -0.007573791779577732, 0.010981344617903233, 0.018468962982296944, 0.01603393629193306, 0.013795612379908562, -0.003194123040884733, -0.0022997562773525715, 0.0039013128262013197, 0.01372484676539898, -0.010653182864189148, 0.0038119773380458355, 0.010912301018834114, 0.012719187885522842, 0.03066457435488701, 0.0058760615065693855, -0.0065949829295277596, -0.005574912764132023, -0.004807585850358009, -0.014111689291894436, -0.0026980573311448097, 0.015375927090644836, 0.015211849473416805, -0.0165352001786232, -0.011274967342615128, 0.028650395572185516, -0.025833681225776672, -0.0022261524572968483, -0.01085653342306614, -0.011449065990746021, -0.011072354391217232, -0.0003414936363697052, -0.016887184232473373, 0.007954509928822517, -0.03310876339673996, 0.008815187960863113, -0.0022437956649810076, -0.0185258649289608, -0.019819922745227814, 0.010146761313080788, 0.003991859965026379, -0.01866491138935089, -0.00021353992633521557, -0.02406446263194084, 0.004035117104649544, -0.03086042031645775, -0.00966330710798502, 0.009277119301259518, -0.006188042927533388, -0.019307361915707588, 0.0577067993581295, -0.013752985745668411, -0.004002683330327272, 0.038171302527189255, 0.0029835947789251804, -0.018497318029403687, -0.07423989474773407, -0.02384471893310547, -0.001250697299838066, -0.010179796256124973, 0.013753584586083889, 0.01582789607346058, -0.014020715840160847, 0.007184055633842945, 0.002829816658049822, -0.0040236953645944595, 0.019976545125246048, -0.03503657132387161, 0.0034828423522412777, 0.007033765781670809, 0.014261577278375626, 0.04614035412669182, -0.019205242395401, -0.0071075186133384705, 0.0048152608796954155, -0.005888119339942932, 0.011675352230668068, 0.008643046021461487, -0.005537683144211769, -0.00894222967326641, -0.0039018893148750067, -0.07954083383083344, 0.008885577321052551, -0.004066459834575653, 0.00785765703767538, -0.010006890632212162, 0.007938227616250515, 0.028874799609184265, -0.03608618676662445, 0.02759244292974472, -0.019329432398080826, 0.016921767964959145, 0.011117694899439812, -0.024310845881700516, -0.013759110122919083, 0.002113542053848505, -0.005992427468299866, 0.033597588539123535, 0.0031008985824882984, -0.017129670828580856, -0.019251666963100433, -0.02556360326707363, 0.011631662026047707, -0.010650675743818283, 0.01003003679215908, -0.007992472499608994, -0.030300874263048172, -0.021469568833708763, 0.02002093568444252, -0.006633113604038954, -0.009299850091338158, -0.017437530681490898, -0.023583903908729553, -0.02439151704311371, -0.004748447332531214, -0.03290266916155815, -0.015776127576828003, 0.004986257292330265, -0.02354574203491211, -0.007114594802260399, 0.0012186840176582336, -0.004863101523369551, -0.012279794551432133, -0.002253683051094413, 0.012162655591964722, 0.024402007460594177, -0.004010440316051245, 0.007863900624215603, -0.004825537092983723, 0.0021326886489987373, -0.000911329872906208, 0.0067816502414643764, 0.012210633605718613, 0.02477014809846878, 0.018382728099822998, -0.02795015089213848, 0.017147891223430634, 0.00238668080419302, -0.01204104907810688, 0.015948615968227386, 0.011070745065808296, -0.01418396644294262, 0.013553516939282417, 0.01307244598865509, 0.07049867510795593, -0.024596232920885086, -0.015675265341997147, 0.004116477444767952, 0.0016232733614742756, 0.003464361187070608, -0.025300579145550728, 0.0072070537135005, -0.067320816218853, -0.013666749931871891, 0.004122038371860981, -0.0035067498683929443, -0.007735928520560265, 0.015703417360782623, -0.00959736667573452, 0.04133269190788269, -0.01846662349998951, 0.014899976551532745, -0.021651828661561012, -0.01955467090010643, 0.017276624217629433, 0.022234421223402023, -0.0208534337580204, 0.039092034101486206, -0.039156559854745865, -0.031083835288882256, 0.008377199992537498, 0.023418359458446503, -0.02406448684632778, 0.014931870624423027, -0.028771627694368362, -0.009650325402617455, 0.006397959776222706, -0.023057997226715088, 0.028749272227287292, 0.00927274115383625, -0.006145271938294172, 0.010974823497235775, -0.030620791018009186, -0.014890183694660664, 0.0075469547882676125, 0.012532031163573265, -0.0019306375179439783, 0.010294056497514248, 0.00004902365617454052, 0.011010187678039074, 0.014089813455939293, 0.017752986401319504, 0.007989051751792431, -0.0017834282480180264, 0.017467346042394638, 0.009294599294662476, 0.0014344886876642704, -0.00423280056566, 0.01789167709648609, 0.014578999020159245, -0.027893798425793648, 0.01980639435350895, -0.01283041201531887, -0.0015778004890307784, 0.009742333553731441, -0.00980580598115921, 0.014521422795951366, -0.017954271286725998, 0.03565318137407303, -0.03306211158633232, 0.0016202658880501986, -0.03146539255976677, -0.020757678896188736, 0.017796652391552925, 0.012076027691364288, 0.004231247119605541, 0.008846165612339973, 0.026368968188762665, 0.0293261855840683, -0.0008136476390063763, 0.02931748330593109, 0.0020715314894914627, -0.000583017710596323, 0.008267617784440517, -0.016933413222432137, 0.02160554938018322, 0.03488389775156975, 0.0025658176746219397, -0.05351502448320389, 0.005333381704986095, -0.01279479544609785, 0.03357469290494919, -0.002539363456889987, 0.014344274997711182, 0.0040355101227760315, -0.002432095119729638, 0.003571512643247843, -0.0073639401234686375, 0.009192155674099922, 0.036710288375616074, -0.012336969375610352, 0.004352468065917492, -0.019451051950454712, 0.00784501526504755, 0.0031208135187625885, -0.011389085091650486, 0.010585935786366463, 0.015866084024310112, -0.02430281788110733, -0.0050424253568053246, -0.01340023148804903, 0.01322060078382492, -0.0017156103858724236, 0.011224099434912205, 0.00973188690841198, -0.009323369711637497, 0.035122890025377274, -0.002554166130721569, 0.01787431165575981, 0.02532953768968582, -0.00886109471321106, -0.05646110326051712, -0.003401290625333786, -0.019502954557538033, 0.000549244461581111, -0.01014957670122385, -0.00929584912955761, 0.04867017641663551, 0.0001047023106366396, -0.01745886169373989, -0.009624090045690536, 0.02436118945479393, 0.010651513934135437, -0.018014349043369293, 0.012484850361943245, 0.02226991206407547, 0.00963570922613144, 0.04590251296758652, 0.03234998881816864, 0.014407568611204624, 0.004465736914426088, 0.0034445994533598423, -0.018560854718089104, 0.0025764591991901398, -0.02351527474820614, -0.027874624356627464, 0.003202354535460472, -0.024384014308452606, 0.011588826775550842, -0.019582269713282585, -0.02232460305094719, 0.030909758061170578, 0.007056949660181999, -0.0022680885158479214, -0.00507783330976963, 0.027099810540676117, 0.0023190039210021496, -0.012546280398964882, -0.02672952227294445, 0.005495625082403421, 0.035538092255592346, 0.017462201416492462, -0.002615313744172454, 0.0049091605469584465, 0.017480291426181793, 0.008202708326280117, -0.05025436356663704, -0.02457396686077118, 0.038487233221530914, -0.00511071365326643, 0.0043614828027784824, 0.028573811054229736, 0.0004902370274066925, 0.021402642130851746, -0.011849038302898407, -0.011025572195649147, -0.0009245835244655609, 0.024652626365423203, -0.026099078357219696, -0.006861622910946608, -0.03264043480157852, -0.01662726327776909, 0.007674979977309704, -0.018712442368268967, -0.02007867395877838, 0.011013409122824669, -0.004626983776688576, -0.010108957067131996, 0.002536937827244401, -0.01829226315021515, 0.0037646908313035965, -0.011451100930571556, 0.0020929179154336452, 0.02438441850244999, 0.010691264644265175, 0.02149074897170067, -0.022123679518699646, 0.007959237322211266, 0.018623709678649902, -0.004361599683761597, 0.018364256247878075, 0.007078089751303196, 0.014907232485711575, -0.009894542396068573, -0.0018517496064305305, -0.0039219968020915985 ]
[ 0.5873351097106934, -0.005878264084458351, -0.10943779349327087, 0.05656706169247627, 0.3410162329673767, 0.5082679986953735, 0.05004534497857094, -0.3073939383029938, 0.046714894473552704, -0.5332619547843933, 0.4169439673423767, 0.39287057518959045, -0.2648249864578247, 0.09815968573093414, 0.32139673829078674, 0.18510547280311584, 0.06073091924190521, 0.24926172196865082, -0.16808725893497467, -0.954850435256958, -0.6628860831260681, -0.2678172290325165, 0.49451327323913574, 0.30043718218803406, 0.22577884793281555, -0.15601524710655212, 0.19132384657859802, -0.9272333383560181, 0.2737043499946594, 0.027169574052095413, 0.21588468551635742, 0.15290303528308868, -0.10894698649644852, -0.24079109728336334, -0.3034482002258301, -0.023214679211378098, -0.08203300088644028, 0.15713608264923096, 0.10364767163991928, -0.15826261043548584, -0.2799179255962372, -0.07387612760066986, -0.025653742253780365, 0.5355792045593262, -0.19708940386772156, -0.04145845025777817, -0.8934019804000854, 0.35716018080711365, 0.2348652482032776, 0.16856014728546143, -0.2959316670894623, -0.09181838482618332, 0.24674564599990845, 0.3579656183719635, 0.0990457683801651, 0.2309732288122177, -0.6842248439788818, -0.5002065300941467, 0.2239920198917389, -0.8641341328620911, 0.4785594344139099, 0.08246039599180222, -0.08762726187705994, 0.0660678893327713, -0.12037944048643112, 0.43920058012008667, 0.26781922578811646, -0.2958194315433502, -0.6666335463523865, -0.23871470987796783, 0.016676336526870728, 0.1747097373008728, -0.4309495687484741, -0.09643532335758209, 0.2650473713874817, 0.25698840618133545, -0.3054331839084625, -0.15891194343566895, 0.41256365180015564, 0.2734200656414032, -0.1873682290315628, 0.5008533596992493, 0.15846264362335205, -0.09477723389863968, 0.6869878768920898, 0.42492952942848206, -0.07828700542449951, 0.45930758118629456, -0.12088944017887115, -0.03649250790476799, -0.14946596324443817, -0.23018258810043335, 0.13632649183273315, -0.06618055701255798, 0.37596386671066284, 0.7768659591674805, 0.389565110206604, 0.08323642611503601, -0.17267605662345886, 0.4316243827342987, -0.12232326716184616, -0.1331728845834732, -0.31784582138061523, -0.6926490664482117, -0.7959139347076416, -0.051780421286821365, -0.12398360669612885, -0.21139630675315857, -0.3600033223628998, -0.11504267156124115, -0.13924789428710938, -0.05421239137649536, -0.4088982343673706, -0.08764925599098206, 0.02251737006008625, 0.08128537982702255, 0.2606342136859894, -0.10424739122390747, -0.0603228397667408, 0.1073230728507042, -0.7049587965011597, 0.8284119367599487, -0.21852225065231323, 0.35454240441322327, -0.37895455956459045, -0.08843456953763962, 0.4263729155063629, 0.09387505054473877, -0.8250745534896851, 0.30421221256256104, 0.03898913785815239, 0.9901819229125977, -0.27316614985466003, -0.00007429585821228102, -0.33037135004997253, 0.2095283567905426, 0.473006010055542, 0.3567016124725342, 0.4073733389377594, 0.4159529507160187, -0.5826447010040283, -0.6808376312255859, -0.19112363457679749, 0.2309870570898056, -0.04347170516848564, -0.2699222266674042, -0.009344256483018398, 0.08031626790761948, 0.2833207845687866, -0.14806963503360748, 0.027327558025717735, -0.29337289929389954, -0.05097128823399544, -0.19972574710845947, -0.3012330234050751, 0.2747341990470886, 0.02113652601838112, -0.15636113286018372, 0.15143810212612152, 0.21039125323295593, 0.28071901202201843, 0.16865943372249603, -0.26461178064346313, 0.09384947270154953, 0.1770583689212799, 0.16024550795555115, 0.14220771193504333, 0.253158837556839, -0.4407407343387604, -0.09600365906953812, -0.16636617481708527, -0.19546253979206085, 0.05289909616112709, -0.7772950530052185, -0.6033700704574585, 0.02109207585453987, 0.7861986756324768, 0.21407867968082428, -0.22281768918037415, 0.014574330300092697, -0.6037168502807617, -0.08108080923557281, -0.03414292633533478, -0.6524512767791748, 0.6747686862945557, -0.17803731560707092, 0.2168182134628296, 0.10211680829524994, -0.47472530603408813, 0.19295494258403778, -0.4565015137195587, -0.23774030804634094, 0.8269279599189758, -0.8875061869621277, 1.8102885484695435, -0.6752710342407227, 0.32821014523506165, 1.465760588645935, 0.06832599639892578, 0.08476925641298294, -0.11617797613143921, 0.08702924102544785, 0.6397755146026611, -0.35276666283607483, -0.6743022799491882, 0.1682938039302826, -0.10449173301458359, -0.027771122753620148, -0.3005303740501404, -0.29707807302474976, 0.49992138147354126, 0.14452508091926575, -0.04402448982000351, 0.06667589396238327, 0.030480144545435905, -0.368374764919281, 0.12703870236873627, 0.09425411373376846, -0.62698894739151, -0.27477747201919556, 0.6609317064285278, -0.4595890939235687, 0.548345685005188, 0.5270319581031799, -0.278229683637619, 0.16003896296024323, -0.08990086615085602, -0.22923080623149872, 0.6161544919013977, -0.19726920127868652, -0.3635106086730957, -0.6029404997825623, -0.062256086617708206, -0.5644267201423645, 0.019767696037888527, -0.06573949009180069, 0.07921869307756424, -0.12654384970664978, -0.5838714838027954, 0.11786281317472458, 0.18103767931461334, 0.543010950088501, -0.7128267288208008, -0.07748494297266006, -0.020263593643903732, -0.10466358810663223, -0.012978712096810341, 0.19481688737869263, -0.6671499609947205, 0.12764117121696472, -0.18384532630443573, 0.3738349378108978, 0.15388140082359314, -0.26710227131843567, 0.1956072449684143, -0.01532929390668869, 0.11751701682806015, -0.5777992010116577, 0.07264012843370438, -0.6024540662765503, 0.7702432870864868, -0.08772251009941101, 0.3405493497848511, 0.44129183888435364, 0.15842615067958832, -0.6957804560661316, -0.7201462388038635, -0.6227985620498657, 1.1590386629104614, 0.731168270111084, 0.7119324207305908, -0.025537211447954178, -0.8038675785064697, 0.2193109691143036, 0.1832149475812912, -0.13488587737083435, 0.053519442677497864, 0.1091124564409256, -0.3313167989253998, -0.18302419781684875, 0.004688899498432875, -0.014138292521238327, 0.44460076093673706, -0.46035802364349365, 0.2693013846874237, 0.49280211329460144, -0.022094758227467537, -0.238954097032547, 0.1866258680820465, -0.12529854476451874, 0.4080891013145447, 0.17535032331943512, -0.010207115672528744, -0.5264922976493835, 0.9502831101417542, -0.0955088883638382, 0.2293621003627777, 0.5667724013328552, 0.5148632526397705, 0.6542946696281433, -0.16496355831623077, 0.3279375731945038, -0.2452743500471115, -0.07971645146608353, 0.17406560480594635, 0.13872256875038147, -0.10365501791238785, 0.20781797170639038, -5.96135139465332, 0.26184549927711487, 0.15363140404224396, -0.6099331974983215, -0.17298154532909393, 0.02468450553715229, 0.44668036699295044, 0.11844224482774734, 0.2929474711418152, -0.2477828562259674, 0.12182044982910156, 0.506808876991272, -0.19434845447540283, -0.07424472272396088, -0.19754494726657867, 0.03374412655830383, 0.029212510213255882, 0.18782596290111542, 0.36187943816185, -0.0745740681886673, -0.1453140377998352, -0.5305823683738708, 0.21813900768756866, 0.5982667803764343, 0.10131258517503738, -0.005653803702443838, -1.061640977859497, -0.030010348185896873, -0.0036831707693636417, -0.12392056733369827, -0.31070634722709656, -0.5457512736320496, 0.46932390332221985, -0.3711985945701599, -0.10835275053977966, 0.028177732601761818, 0.20529566705226898, -0.0327293761074543, -0.042802855372428894, -0.6808602809906006, 0.22669681906700134, -0.06286196410655975, -0.5246752500534058, -0.28132033348083496, -0.16066963970661163, 0.1093352735042572, -0.016622181981801987, 0.31906741857528687, -0.30032774806022644, 0.7946131825447083, -0.3931053578853607, -0.11257966607809067, 0.3376368582248688, 0.11717834323644638, 0.4900975227355957, -0.04610191285610199, -0.2746545076370239, -0.09583017975091934, -0.8006999492645264, 0.5397350788116455, -0.44144734740257263, -0.38912150263786316, -0.24517442286014557, -0.769355058670044, -0.13047531247138977, -0.2295013964176178, -0.8988075852394104, -0.42676255106925964, -0.04702918604016304, 0.28831222653388977, -0.04734230786561966, 0.6409863829612732, 0.4101899564266205, -0.6594590544700623, 0.15424446761608124, -0.5649943351745605, -0.07336177676916122, 0.10749322175979614, -0.10768499225378036, 0.0004700394638348371, -0.00369098293595016, 0.2327224314212799, 0.17054665088653564, -0.14351774752140045, 0.1776755154132843, 0.14998069405555725, -0.1988711655139923, -0.3801334500312805, -0.2597567141056061, 0.4513470232486725, 0.04306982457637787, -0.39992138743400574, -0.48343148827552795, 0.5806090235710144, 0.36924824118614197, 0.18031440675258636, 0.2770915627479553, 0.6694475412368774, 0.2556774318218231, -0.007152213249355555, 1.1927591562271118, 0.39581072330474854, -0.39880266785621643, -0.9509482979774475, -0.3872877061367035, 0.3397255539894104, -0.8354348540306091, 0.2989444136619568, 0.4485798478126526, -0.24061985313892365, -0.2936902940273285, -0.048064280301332474, -0.25509727001190186, -0.25910311937332153, 0.3768923878669739, -0.04684095084667206, -0.4391756057739258, 0.07522700726985931, 0.7613863348960876, -0.15485380589962006, 0.46087682247161865, 0.10217112302780151, 0.0024168186355382204, -0.06152823567390442, 0.32031744718551636, 0.1274988353252411, 0.6953094005584717, 0.5142014622688293, -1.384407877922058, -0.2726166248321533, 0.18083961308002472, 0.11558552831411362, -0.48801812529563904, 0.04601367935538292, 0.2106713503599167, -0.2839008867740631, -0.5048231482505798, 0.2636975944042206, 0.24016928672790527, 0.1289592981338501, 0.39275985956192017, -0.11765392869710922, -0.13619594275951385, 0.18711815774440765, 0.07522204518318176, 0.33760973811149597, -0.2776259183883667, -0.1677817851305008, -0.2855539321899414, -0.17922334372997284, 0.10004628449678421, -0.5643815994262695, 0.42397913336753845, -0.6079748868942261, -0.16591767966747284, 0.38007619976997375, 0.6289088129997253, -0.1883591264486313, 0.37571659684181213, -0.6243910193443298, 0.013462898321449757, 0.27806368470191956, -0.6856603622436523, 0.006929103750735521, -0.0034128830302506685, -0.4800637662410736, -0.31911617517471313, -0.03184692934155464, -0.36764460802078247, 0.16109557449817657, -0.2538653016090393, -0.30655184388160706, -0.008743754588067532, -0.14665912091732025, -0.05188341438770294, -0.19294491410255432, -0.5299957990646362, 0.18952004611492157, 0.16964726150035858, 0.25524821877479553, 0.30540981888771057, -0.5950495004653931, 0.15390723943710327, 0.08551441133022308, 0.9140958189964294, 0.03346176818013191, 0.12128055095672607, -0.10111052542924881, -0.5633422136306763, 0.11462914198637009, -0.02233155257999897, 0.37884029746055603, 0.27007582783699036, -0.26700830459594727, -0.03391653671860695, 0.046197231858968735, 0.11900745332241058, -0.0562875010073185, 0.47595876455307007, -0.17479735612869263, 0.3304416835308075, 0.2893579602241516, -0.10807722061872482, 0.2597731053829193, 0.8591920137405396, -0.027750715613365173, -0.32253381609916687, -0.02818405069410801, 0.001938218716531992, 0.10133470594882965, -0.21721592545509338, -0.44526025652885437, -0.04399704188108444, 0.4595871567726135, 0.10897690802812576, 0.01273300126194954, 0.19461145997047424, -0.702548086643219, -0.23870538175106049, 0.40925344824790955, 0.221709743142128, -0.06466072797775269, -0.2594410479068756, -0.15139135718345642, -0.1251164972782135, -0.054168108850717545, -0.06481341272592545, -0.9543817639350891, -0.1064850389957428, 0.06944821774959564, -0.6080941557884216, -0.33688294887542725, 0.4948451817035675, -0.11997725814580917, -0.5260456204414368, -0.6435388922691345, -0.034049589186906815, 0.02454325556755066, -0.1892952173948288, 0.5190385580062866, 0.29062896966934204, 0.5499569773674011, -0.19253872334957123, -0.6412256956100464, -0.25066348910331726, 0.40407001972198486, 0.027002675458788872, -0.3984743058681488, -0.2636274993419647, -0.41568630933761597, -0.11342561990022659, -0.3619191348552704, 0.15639832615852356, 0.005599420517683029, 0.8643028140068054, 0.5737618803977966, 0.13356705009937286, -0.07434377819299698, -0.00908740796148777, -0.3375643193721771, 0.07982198148965836, -0.1511085480451584, -0.5770201086997986, 0.06605800986289978, 0.5915155410766602, 0.23293007910251617, 0.09388986229896545, -0.5080246925354004, 0.31579574942588806, -0.08813466876745224, 0.06298966705799103, -0.13312914967536926, 0.535015344619751, 0.150443434715271, -0.06811531633138657, 0.23716509342193604, 0.1066579595208168, 0.2555251121520996, 0.03742261976003647, 0.23566894233226776, -0.29119420051574707, -0.6331750154495239, 0.4312298893928528, 0.03608833625912666, 0.794312059879303, -0.6584904789924622, 0.09287800639867783, -0.5411427617073059, 0.7093219757080078, -0.871444046497345, -0.2480400949716568, -0.057477567344903946, -0.5829261541366577, -0.2560592293739319, -0.02601202391088009, 0.29186245799064636, 0.25318577885627747, -0.08200491964817047, 0.12752246856689453, -0.03589748963713646, -0.545478343963623, 0.6817681789398193, 0.18988129496574402, -0.5003142952919006, 0.047658633440732956, 0.18086424469947815, 0.1874021589756012, 0.47016119956970215, -0.36084553599357605, 0.4728047549724579, 0.1334024965763092, -0.10482769459486008, 0.40816226601600647, -0.07569381594657898, -0.35070040822029114, -0.19820855557918549, -0.3021375238895416, -0.16590432822704315, 0.4018172323703766, 0.11362571269273758, 0.08714285492897034, 0.7072950601577759, 0.6366068124771118, -0.05638374388217926, -0.21497197449207306, 0.7118555307388306, 0.23551718890666962, 0.405735045671463, -0.29198917746543884, 0.688341498374939, 0.6677869558334351, 0.543827474117279, 0.07259687781333923, 0.31202390789985657, 0.39139896631240845, -0.04697785899043083, 0.14849211275577545, -0.20539693534374237, -0.36035817861557007, 0.3785991072654724, 0.616978108882904, 0.34685733914375305, -0.22282452881336212, 0.014311804436147213, 0.09490004926919937, 0.3488585948944092, -0.3455919623374939, 0.88851398229599, -0.09388232231140137, 0.11282672733068466, 0.6799022555351257, -0.29535242915153503, 0.11062343418598175, 0.6715121865272522, -0.2302577793598175, 0.14755746722221375, 0.4021710753440857, -0.31701338291168213, -0.3636026382446289, -0.043744686990976334, -0.5622766017913818, 0.14892899990081787, 0.3230619430541992, 0.5741045475006104, 0.26892536878585815, 0.008685745298862457, 0.31576043367385864, 0.2562054395675659, 0.3824828565120697, -0.3798252046108246, 0.3283788859844208, -0.1600256711244583, -0.2583550214767456, -0.24814146757125854, -0.16394177079200745, -0.6531403660774231, -0.24846820533275604, -0.39010927081108093, -0.30100494623184204, 0.12364824116230011, -0.3321644067764282, -0.3061971366405487, 0.15107609331607819, -0.4467591345310211, -0.2906986176967621, -0.08491315692663193, -0.0773257315158844, -0.29660236835479736, 0.16232867538928986, 0.17208130657672882, 0.1327791064977646, -0.9827027916908264, 0.24441401660442352, 0.30203527212142944, -0.007021845318377018, 0.1100035011768341, -0.03925791382789612, 0.21406345069408417, 0.41096869111061096, 0.3894945979118347, -0.04247376322746277, 0.06934160739183426, -0.13415513932704926, 0.01540772058069706, -0.19782885909080505, 0.30172333121299744, -0.5019343495368958, -0.02188783697783947, -0.49194252490997314, 0.032978735864162445, 0.6209513545036316, 0.7940431237220764, -0.2733365595340729, 0.26677799224853516, -0.11228612065315247, 0.49038398265838623, 0.5084937810897827, -0.22403207421302795, 0.16966749727725983, -0.5020778179168701, -0.32331493496894836, -0.3529309332370758, 0.3570448160171509, -0.10192833840847015, -0.5627732872962952, -0.06583412736654282, 0.38289931416511536, 0.2991531193256378, -0.1452077329158783, 0.322272390127182, -0.5315369367599487, -0.30210232734680176, -0.4879918396472931, 0.058346014469861984, -0.7088676691055298, 0.36583203077316284, -0.21353305876255035, -0.15514282882213593, 0.055308807641267776, -0.22117337584495544, 0.3877916634082794, -0.06725172698497772, -0.043699711561203, 0.5048084855079651, -0.0626349076628685, 0.23287364840507507, 0.18588535487651825, -0.7578014135360718, -0.30758774280548096, -0.06544224917888641, 0.23687277734279633, -0.4469204246997833, 0.044496726244688034, -0.2125798463821411, -0.1296299695968628, 0.15870431065559387, 0.006896982900798321, -0.2836208641529083, -0.14128457009792328, -0.10889998823404312 ]
The Arabidopsis genome contains a family of v-SNAREs: VTI11, VTI12, and VTI13. Only VTI11 and VTI12 are expressed at appreciable levels. Although these two proteins are 60% identical, they complement different transport pathways when expressed in the yeast vti1 mutant. VTI11 was identified recently as the mutated gene in the shoot gravitropic mutant zig. Here, we show that the vti11 zig mutant has defects in vascular patterning and auxin transport. An Arabidopsis T-DNA insertion mutant, vti12, had a normal phenotype under nutrient-rich growth conditions. However, under nutrient-poor conditions, vti12 showed an accelerated senescence phenotype, suggesting that VTI12 may play a role in the plant autophagy pathway. VTI11 and VTI12 also were able to substitute for each other in their respective SNARE complexes, and a double-mutant cross between zig and vti12 was embryo lethal. These results suggest that some VTI1 protein was necessary for plant viability and that the two proteins were partially functionally redundant.
[ -0.007483090739697218, 0.0013345475308597088, -0.013822837732732296, 0.02732190303504467, -0.0009663307573646307, 0.010372977703809738, 0.012157817371189594, 0.023734424263238907, -0.012812660075724125, -0.003454427467659116, -0.014565732330083847, 0.0144901592284441, -0.03867720812559128, 0.005435234867036343, 0.023473255336284637, -0.0008039355743676424, -0.015963628888130188, 0.0009462253656238317, 0.01915154419839382, 0.05099685490131378, 0.03957149386405945, 0.004269959405064583, 0.011734379455447197, -0.022794565185904503, 0.0012566139921545982, 0.01812342368066311, 0.020616382360458374, -0.009066708385944366, -0.03894653171300888, -0.0024628378450870514, 0.00278281862847507, 0.011446364223957062, 0.011883853003382683, 0.03834422677755356, -0.002350671449676156, 0.013451777398586273, -0.022136831656098366, 0.0305840652436018, 0.0064367493614554405, -0.0064478181302547455, -0.03285408020019531, -0.01905721239745617, 0.006787816993892193, -0.036786556243896484, -0.00906238704919815, -0.006443270947784185, -0.0032222960144281387, -0.00718547310680151, 0.011318936944007874, 0.0013758746208623052, -0.013739306479692459, -0.0018285743426531553, -0.010241437703371048, 0.03289239853620529, -0.00778472563251853, -0.021368321031332016, 0.018163150176405907, -0.013196755200624466, -0.0040756706148386, -0.007565705105662346, 0.006954981479793787, 0.0216679647564888, 0.01076073944568634, -0.009051612578332424, 0.037123020738363266, -0.06613152474164963, 0.02786066383123398, 0.011834317818284035, 0.003226239699870348, -0.007035479880869389, -0.015241716988384724, 0.008468689396977425, 0.0029143556021153927, -0.010970080271363258, -0.009425913915038109, -0.03620811179280281, -0.006465346552431583, 0.025253385305404663, 0.028975915163755417, 0.024005284532904625, 0.009803585708141327, -0.021326914429664612, -0.013896742835640907, 0.013177954591810703, -0.015197182074189186, -0.0009729815647006035, -0.027278251945972443, 0.02206934243440628, 0.02794371172785759, -0.009177064523100853, -0.0000509447418153286, 0.014553321525454521, -0.0399291068315506, -0.014168741181492805, -0.0310635007917881, -0.021674994379281998, -0.0032060309313237667, 0.003394316416233778, 0.02078867331147194, 0.015666639432311058, -0.01906418800354004, 0.027693264186382294, 0.015756623819470406, 0.02818944863975048, -0.015303049236536026, 0.01217346265912056, -0.00576974730938673, 0.0178763959556818, 0.030751144513487816, 0.014457951299846172, -0.007961940951645374, -0.0014140591956675053, 0.011349726468324661, 0.03592803329229355, -0.009561020880937576, -0.0010454950388520956, -0.009107187390327454, 0.006902477703988552, 0.008894895203411579, -0.0014471369795501232, 0.01232109684497118, -0.017734475433826447, 0.005636637099087238, 0.023645076900720596, 0.00839335098862648, 0.003489087801426649, 0.00341764185577631, -0.03737832233309746, 0.009167454205453396, -0.0017532981000840664, -0.008612074889242649, 0.01702520251274109, -0.006706766784191132, 0.000301889143884182, -0.0034495436120778322, -0.007214386947453022, -0.02887778729200363, 0.009132000617682934, -0.031463902443647385, 0.0010383212938904762, 0.030216239392757416, 0.007989207282662392, 0.015953868627548218, 0.010680395178496838, 0.020522650331258774, 0.015873782336711884, -0.001146762864664197, -0.013407230377197266, 0.012451749294996262, -0.01148721668869257, -0.013245418667793274, -0.004866382572799921, 0.005550318863242865, -0.007184719666838646, 0.011945649981498718, -0.002416237723082304, -0.00966957863420248, -0.011407699435949326, 0.003026328980922699, 0.00815883744508028, -0.013839812017977238, -0.01450805552303791, -0.0070457737892866135, 0.010513012297451496, -0.007104257587343454, 0.013571187853813171, 0.003400794230401516, -0.016013935208320618, 0.011817114427685738, 0.009161711670458317, -0.00979040190577507, 0.0073649282567203045, -0.0008056435035541654, 0.00940705742686987, -0.022019008174538612, -0.004695524461567402, 0.016081705689430237, 0.0057532996870577335, -0.032282907515764236, 0.06640924513339996, 0.009009173139929771, -0.020519999787211418, 0.00986037403345108, -0.0009640557691454887, 0.0037135216407477856, -0.015556678175926208, 0.012238816358149052, -0.025155415758490562, -0.008067987859249115, -0.012985216453671455, 0.011772065423429012, 0.005163541994988918, 0.006864403374493122, 0.024628160521388054, -0.04478093236684799, 0.0023757722228765488, 0.02283679135143757, 0.006221633404493332, 0.02414405159652233, 0.02174387499690056, -0.005519606173038483, 0.007684104144573212, 0.024586401879787445, -0.003890878986567259, 0.024008244276046753, 0.014232456684112549, 0.009825107641518116, -0.009302631951868534, -0.01910286769270897, 0.006901371292769909, 0.01354934461414814, -0.009046209044754505, 0.0023182714357972145, -0.007144200149923563, -0.04446060210466385, 0.0018358624074608088, -0.008661189116537571, 0.0021575307473540306, 0.04314775392413139, -0.01368197612464428, -0.004328055307269096, -0.008894415572285652, -0.015566688030958176, -0.014655995182693005, 0.020939011126756668, 0.0015287618152797222, 0.016041528433561325, 0.014116049744188786, -0.013108237646520138, -0.007417391985654831, -0.012970101088285446, -0.029512017965316772, -0.019365303218364716, 0.007028744090348482, 0.027951113879680634, -0.005180176813155413, 0.021732088178396225, 0.010568834841251373, 0.003349216189235449, -0.006785036064684391, -0.008422128856182098, 0.00535545963793993, 0.015216963365674019, 0.007554757408797741, -0.0133168064057827, 0.011636211536824703, -0.01880047656595707, 0.0112787876278162, 0.002002185210585594, -0.0418122261762619, 0.011306016705930233, 0.012162312865257263, 0.003843095153570175, -0.0492868572473526, 0.007540796883404255, -0.02268189750611782, 0.021000897511839867, -0.009072449058294296, 0.026174359023571014, -0.0287539754062891, 0.00268074544146657, 0.011829357594251633, -0.008860897272825241, -0.009962226264178753, 0.005602615885436535, 0.02813725918531418, 0.04151390492916107, 0.020977243781089783, 0.01379805151373148, -0.008068756200373173, 0.011295570060610771, -0.015636999160051346, -0.0047539277002215385, -0.08074080944061279, -0.01713094301521778, -0.0013523377710953355, -0.049426354467868805, 0.0048206341452896595, 0.04636775329709053, -0.030080363154411316, 0.004379496909677982, -0.013224564492702484, 0.02670001983642578, 0.01926795020699501, -0.007362252566963434, -0.013292958959937096, 0.005348560865968466, 0.0360213965177536, -0.017327718436717987, 0.020031582564115524, -0.000355597585439682, -0.028451304882764816, -0.011454062536358833, 0.02103397250175476, -0.021477634087204933, 0.019398195669054985, 0.004881914705038071, 0.012404786422848701, 0.01226226519793272, 0.013290594331920147, 0.0007090019062161446, 0.011606507934629917, 0.0016035223379731178, -0.008107553236186504, -0.03087048977613449, 0.009149234741926193, 0.011135983280837536, -0.01856660470366478, 0.0380500853061676, -0.008387014269828796, -0.016910510137677193, 0.013088937848806381, 0.017071256414055824, -0.03055817261338234, 0.027732033282518387, 0.02471262216567993, -0.0008256840519607067, 0.0066971248015761375, 0.011738463304936886, 0.007056936621665955, -0.0024721273221075535, 0.02299463003873825, -0.00004518777132034302, 0.035187408328056335, 0.013603784143924713, 0.019019840285182, 0.02581963688135147, -0.021111272275447845, 0.024464178830385208, 0.002885695081204176, 0.0230272077023983, -0.008972302079200745, -0.013502243906259537, -0.0035659167915582657, 0.022744957357645035, 0.020386088639497757, -0.028689991682767868, 0.001490509370341897, 0.032241661101579666, 0.0060483310371637344, -0.012844891287386417, -0.02065441757440567, 0.012443535029888153, -0.01030748337507248, 0.017200348898768425, -0.014465060085058212, -0.004074946045875549, 0.012648770585656166, -0.010159524157643318, -0.013330298475921154, -0.010526083409786224, 0.009697197005152702, -0.012090399861335754, -0.0242699533700943, 0.024429097771644592, 0.023474596440792084, 0.01167331077158451, -0.01995770074427128, -0.025778284296393394, 0.009689508005976677, 0.015229469165205956, 0.013418846763670444, -0.016372106969356537, -0.012495312839746475, 0.028777608647942543, 0.0035225749015808105, 0.016241218894720078, -0.0005648685619235039, 0.005016334820538759, 0.006436783820390701, 0.0021838711109012365, -0.00886926706880331, 0.010097667574882507, 0.04337199032306671, -0.01361095905303955, -0.003645700868219137, -0.008879403583705425, 0.005468262825161219, 0.0171666257083416, -0.012301863171160221, -0.0036608946975320578, -0.0006181099452078342, -0.0033516648691147566, 0.003961283713579178, -0.01904742419719696, -0.0007884988444857299, -0.008487294428050518, 0.017345383763313293, 0.02660776674747467, -0.02338440716266632, -0.0015420380514115095, 0.0713866651058197, 0.015355091542005539, 0.00865937490016222, 0.009660698473453522, -0.008978357538580894, -0.011212814599275589, -0.0015652193687856197, -0.002444501733407378, -0.01701824553310871, 0.03981205075979233, 0.014010648243129253, -0.013455785810947418, 0.00681290403008461, 0.0037915681023150682, -0.019866447895765305, -0.011603190563619137, 0.005461116321384907, -0.028674017637968063, -0.0029813889414072037, 0.003070888575166464, -0.025281716138124466, -0.019809819757938385, -0.012977195903658867, 0.011073930189013481, -0.012585647404193878, -0.0038949523586779833, 0.014960420317947865, -0.017871126532554626, -0.005966760218143463, 0.014532215893268585, 0.020118702203035355, -0.017163660377264023, -0.016172192990779877, -0.027521777898073196, -0.024455679580569267, -0.004731533117592335, 0.020570877939462662, 0.012709890492260456, -0.005824118386954069, -0.021028902381658554, -0.009166274219751358, -0.015983879566192627, 0.008598266169428825, -0.00048267655074596405, 0.03397933021187782, 0.005144190043210983, 0.04803204536437988, -0.010724039748311043, -0.003478594124317169, 0.0016736984252929688, -0.012560300529003143, -0.0020207089837640524, 0.01389896497130394, 0.017479795962572098, -0.0009907379280775785, -0.005476652644574642, 0.011904384940862656, 0.0013498261105269194, -0.01124556828290224, -0.02246992290019989, -0.011659573763608932, -0.02457096241414547, -0.03939397260546684, -0.008795227855443954, 0.01988917589187622, -0.015896247699856758, -0.021844614297151566, -0.0048130229115486145, -0.024030767381191254, 0.007113298866897821, 0.013087895698845387, 0.0033471910282969475, -0.02999540977180004, 0.0033555706031620502, -0.04681704193353653, -0.007520187180489302, 0.017127128317952156, -0.0231156088411808, 0.054851602762937546, 0.0005849294830113649, 0.006473870482295752, -0.01219506748020649, -0.02491137385368347, -0.019597578793764114, 0.005096993409097195, -0.006161472760140896, -0.011438433080911636, -0.07433030009269714, -0.03967154771089554, -0.006188446655869484, -0.003499520942568779, 0.0017513404600322247, -0.008794429711997509, -0.034068040549755096, 0.012855209410190582, 0.0014349708799272776, -0.005427172407507896, 0.014642192982137203, -0.016723982989788055, 0.012446682900190353, 0.011124445125460625, 0.011424043215811253, 0.005219346843659878, -0.04071187600493431, 0.018311062827706337, -0.019507762044668198, 0.03583086282014847, -0.01447281613945961, 0.010076851584017277, 0.004216410219669342, -0.008709818124771118, -0.009927965700626373, -0.08004216849803925, -0.02960250899195671, 0.002432862762361765, 0.03311959654092789, 0.005501650273799896, 0.007438805885612965, 0.009223511442542076, -0.003867252031341195, 0.02683476358652115, -0.01561407558619976, 0.0216204933822155, 0.0015377635136246681, 0.002829493023455143, -0.023423878476023674, 0.021695248782634735, -0.017246710136532784, 0.015223357826471329, 0.00444924458861351, 0.013585167936980724, -0.008553389459848404, -0.005549679510295391, 0.019127221778035164, -0.012781614437699318, -0.0031910324469208717, -0.004983957856893539, -0.013009034097194672, -0.0434868186712265, 0.020894968882203102, 0.0052586691454052925, -0.02818460389971733, 0.011912520974874496, 0.00001016759779304266, -0.03189808875322342, -0.014576500281691551, 0.02076610177755356, -0.020242126658558846, 0.03758997470140457, 0.02257605455815792, 0.017117438837885857, -0.0200946144759655, -0.004453310277312994, 0.007714533247053623, 0.004144082777202129, 0.030828841030597687, -0.011921568773686886, -0.028219103813171387, 0.011087602004408836, -0.020173609256744385, 0.004403830971568823, 0.0185186006128788, 0.008127223700284958, 0.028228584676980972, -0.007122092880308628, 0.007800904102623463, -0.012434999458491802, -0.016455797478556633, 0.009426367469131947, 0.03915981203317642, 0.013403619639575481, 0.01822349801659584, -0.008777296170592308, 0.03290325030684471, 0.018106073141098022, 0.07117534428834915, -0.01109793595969677, 0.007292554713785648, -0.04875314235687256, -0.020004265010356903, 0.009617960080504417, -0.007579912431538105, -0.010737299919128418, 0.01957682892680168, -0.017240338027477264, -0.005683864466845989, -0.004359956830739975, 0.004404915496706963, 0.011435797438025475, 0.030597809702157974, 0.01983901485800743, 0.006576794199645519, -0.0015006610192358494, 0.005031888373196125, 0.014948655851185322, -0.0018076063133776188, 0.005729498341679573, -0.004435733892023563, -0.012361634522676468, -0.01599404588341713, -0.0019218899542465806, 0.007178924977779388, -0.010773700661957264, -0.01538026612251997, 0.02929074876010418, 0.007781272288411856, 0.020027272403240204, 0.008481170982122421, -0.00680987723171711, 0.014720665290951729, 0.0034495859872549772, 0.011465939693152905, 0.01884501986205578, 0.002839585766196251, -0.04296180605888367, -0.016116339713335037, 0.0007206117734313011, -0.0036210701800882816, -0.0006812275387346745, -0.0031785769388079643, -0.021402720361948013, 0.02533566579222679, -0.017047183588147163, 0.00046503404155373573, 0.008617399260401726, 0.01108396053314209, 0.0034516318701207638, 0.024875307455658913, 0.01277234312146902, 0.003115158760920167, 0.016637567430734634, -0.029464498162269592, 0.022987153381109238, 0.005111281294375658, 0.005493388511240482, 0.002842007437720895, -0.003579774172976613, -0.008663399145007133, -0.0218951553106308, -0.006293675862252712, -0.004731225781142712, 0.02300715073943138, -0.02432381547987461, -0.022816326469182968, 0.018242044374346733, -0.014573811553418636, 0.01821834221482277, 0.011833807453513145, 0.024489067494869232, 0.016219930723309517, 0.01167474314570427, 0.021062713116407394, 0.007484409026801586, 0.035967595875263214, -0.0029944321140646935, -0.010585248470306396, -0.01943080872297287, 0.015312636271119118, -0.007453891448676586, -0.022631706669926643, 0.01496514305472374, -0.024014610797166824, 0.022536812350153923, 0.004146474879235029, 0.014073082245886326, 0.0036621533799916506, 0.015264514833688736, 0.010033710859715939, 0.004051642492413521, 0.007767034694552422, 0.034894488751888275, 0.017446137964725494, 0.011660793796181679, -0.011984683573246002, -0.02227899059653282, 0.043965864926576614, 0.009453598409891129, 0.004280686844140291, 0.003742682747542858, -0.013153146021068096, -0.006010786164551973, 0.024502908810973167, -0.011716739274561405, -0.02128829061985016, 0.008455375209450722, 0.03967487812042236, 0.028025701642036438, 0.0017387541010975838, -0.0003535989671945572, -0.012246927246451378, 0.015742497518658638, -0.010585708543658257, 0.028685549274086952, -0.02896186336874962, -0.01821090467274189, -0.02371835522353649, 0.018974464386701584, 0.029076294973492622, 0.03029695339500904, -0.004134593065828085, -0.014948947355151176, -0.010061255656182766, -0.0022709465119987726, -0.03449736535549164, -0.017282746732234955, 0.03945852071046829, -0.041080087423324585, -0.006113307550549507, -0.02886335365474224, 0.01418340764939785, -0.023816967383027077, -0.02348102629184723, 0.0012940873857587576, -0.012907451950013638, 0.012929318472743034, 0.0032153530046343803, -0.016277996823191643, 0.002780159469693899, 0.0080407178029418, 0.009169154800474644, 0.0006700195372104645, 0.009421439841389656, 0.021607521921396255, 0.0021331487223505974, -0.005383205600082874, 0.001735973753966391, 0.006858734413981438, -0.0010894255246967077, -0.010374058037996292, -0.016938060522079468, 0.0038038967177271843, 0.009768147952854633, -0.038661740720272064, 0.013113569468259811, 0.0023431451991200447, 0.0003255524206906557, 0.011251837015151978, 0.03153453767299652, 0.013140116818249226, 0.02393362671136856, 0.00017228629440069199, 0.02321263775229454, 0.030197786167263985, -0.037521302700042725, 0.022079970687627792, 0.01594383269548416, -0.0034244535490870476, -0.034729041159152985, 0.0047484152019023895, -0.006256322376430035, -0.0030323134269565344, -0.0005739911575801671, -0.01854027807712555, -0.015043647028505802, 0.005572842434048653, -0.010147443041205406, -0.010449059307575226, 0.022013435140252113, -0.013137787580490112, 0.016381122171878815, -0.019895285367965698, -0.00585076492279768, 0.016785811632871628, 0.00889933854341507, 0.016827713698148727, -0.02283114567399025, -0.02156432718038559, 0.002382236532866955, 0.009255840443074703, -0.0019166816491633654, -0.01829342544078827, -0.012393592856824398, 0.018615737557411194, 0.01107620820403099, 0.005934791639447212, 0.02338442951440811, 0.004615258425474167 ]
[ 0.06624844670295715, -0.22745554149150848, -0.09706103801727295, 0.05755973979830742, -0.37554773688316345, 0.05645350366830826, 0.31021061539649963, -0.1923820823431015, -0.26362118124961853, -0.8028736114501953, 0.17558255791664124, 0.4168657660484314, -0.6545413136482239, 0.08077831566333771, 0.07807905226945877, 0.886195719242096, 0.2220841348171234, 0.49627286195755005, -0.3455680012702942, -0.7140339612960815, -0.016986506059765816, -0.3558385372161865, 1.000798225402832, -0.19978320598602295, 0.28517836332321167, -0.23550637066364288, 0.2603124976158142, 0.34249743819236755, 0.594340980052948, -0.03935789316892624, -0.3092283606529236, 0.37208202481269836, 0.616205632686615, -0.03353000804781914, -0.24892102181911469, -0.3733004331588745, -0.3819824755191803, -0.029386477544903755, 0.35932767391204834, -0.331048846244812, -0.5670987963676453, -0.45554256439208984, -0.28127169609069824, 0.34426844120025635, 0.4548865854740143, -0.15768304467201233, -1.161450743675232, 0.8643341064453125, -0.055468905717134476, 0.180226132273674, 0.08423162251710892, 0.4083215892314911, 0.2827267646789551, 0.12157627195119858, 0.6864156126976013, 0.059087637811899185, -0.9718406200408936, -0.16589441895484924, 0.5349578857421875, -0.5108427405357361, -0.3824489414691925, 0.20542296767234802, -0.03842885419726372, 0.6479743719100952, -0.04612046480178833, 0.7411838173866272, 0.0033258472103625536, -0.3873387575149536, -0.5766931176185608, 0.16216152906417847, -0.02498689666390419, -0.5385556817054749, 0.12830403447151184, -0.13297493755817413, 0.2776769697666168, -0.4505828619003296, -0.8528909683227539, -0.2865222096443176, 0.41254010796546936, 0.19549936056137085, 0.03760591521859169, -0.4177493155002594, -0.039602164179086685, 0.2124563753604889, 0.19382108747959137, 0.31962013244628906, -0.2210818976163864, 0.3033500015735626, -0.9405122399330139, 0.07861997932195663, -0.23895367980003357, -0.08439549058675766, 0.7089658975601196, 0.45096680521965027, 0.03368816152215004, 0.31095829606056213, -0.021530000492930412, -0.15853238105773926, -0.18008911609649658, 0.4324043393135071, -0.3857690989971161, 0.7531363368034363, 0.03458905592560768, -0.24507325887680054, -0.66930091381073, -0.13279442489147186, -0.11784323304891586, -0.36433812975883484, -0.4499242603778839, 0.1962205469608307, -0.4568430483341217, -0.13563916087150574, -0.275736927986145, -0.39688894152641296, 0.3067986071109772, 0.28751838207244873, 0.1846223920583725, -0.6169736385345459, 0.5504316091537476, 0.2041996419429779, -0.3190138638019562, 1.0298211574554443, 0.019024183973670006, 0.6793981790542603, -0.036999817937612534, -0.20280884206295013, -0.11353879421949387, -0.329337477684021, 0.09415475279092789, 0.6540331840515137, 0.39497023820877075, 0.8917219042778015, -0.35474875569343567, 0.2806011736392975, -0.2558734118938446, -0.3875909149646759, -0.06426697224378586, 0.1103564202785492, 0.3457765579223633, 0.08205512911081314, -0.5289940237998962, -0.3748965859413147, -0.06108597666025162, -0.14426152408123016, 0.07616154849529266, -0.3980615735054016, -0.005994247272610664, 0.04907098039984703, -0.16906359791755676, -0.44137945771217346, 0.05074787512421608, -0.5909054279327393, -0.8550208210945129, -0.017501184716820717, -0.38878774642944336, -0.03968936949968338, 0.1695142239332199, 0.02232537418603897, -0.12267594039440155, 0.40801912546157837, -0.18048164248466492, -0.18284231424331665, 0.08597324043512344, 0.16451063752174377, 0.2999129295349121, -0.07025308907032013, 0.4660424292087555, 0.5203897356987, 0.05917949602007866, -0.12408016622066498, -0.45306774973869324, -0.33143824338912964, 0.11262041330337524, -0.6706112623214722, -0.18315282464027405, -0.06998274475336075, 0.5138101577758789, -0.3668311536312103, 0.2420075535774231, 0.09726431220769882, -0.697353184223175, -0.054526545107364655, -0.14211279153823853, 0.03720004856586456, 0.24270294606685638, 0.18972736597061157, 0.38725900650024414, 0.06858491152524948, 0.11147820204496384, 0.2645634710788727, -0.2520710825920105, 0.0004296466941013932, 0.5209158062934875, -0.1375919133424759, 1.0040366649627686, 0.01860814169049263, -0.48360660672187805, 0.7838320136070251, 0.3633612096309662, 0.27827873826026917, -0.6130812168121338, 0.17118039727210999, 0.456500768661499, -0.19580483436584473, -0.5518582463264465, 0.05935458093881607, -0.06428956240415573, -0.0727553591132164, 0.0639592781662941, 0.16319052875041962, 0.1596391797065735, -0.4314498007297516, -0.047832880169153214, -0.257554829120636, 0.20467782020568848, -0.5224398374557495, -0.11739412695169449, -0.09877330809831619, -0.07820647954940796, -0.3764151930809021, 0.4343438744544983, -0.6032993793487549, 0.12225784361362457, 0.576882541179657, -0.5442153215408325, 0.5937555432319641, 0.4403243064880371, 0.26177141070365906, 0.6805047392845154, -0.29313552379608154, 0.4840998649597168, -0.10567589104175568, 0.21615612506866455, -0.4252302348613739, -0.11638699471950531, 0.5455240607261658, -0.009396711364388466, 0.045644886791706085, 0.13028991222381592, -0.17577150464057922, -0.06022762879729271, 0.9825528860092163, -0.5666817426681519, -0.10436591506004333, 0.1324228048324585, -0.505962073802948, -0.0828871801495552, 0.05670011788606644, -0.8003766536712646, 0.035237330943346024, -0.055077627301216125, 0.4395638704299927, 0.28285515308380127, -0.45928123593330383, -0.21291254460811615, 0.26325783133506775, 0.21869786083698273, -0.2290550023317337, 0.07975305616855621, -0.1654788851737976, -0.3926945924758911, 0.040948666632175446, -0.0653979480266571, 0.4841918349266052, 0.32862693071365356, -0.2790870666503906, -0.7609928846359253, -0.014962130226194859, 0.9805681109428406, 0.6724609732627869, 0.9536791443824768, -0.04755778983235359, -0.9224031567573547, -0.1769513487815857, 0.11993023753166199, -0.2943061292171478, -0.18639156222343445, 0.9269163012504578, 0.029428493231534958, -0.17072804272174835, -0.47544339299201965, 0.3244304656982422, 1.018626093864441, 0.0012459310237318277, -0.3445766270160675, 0.26226499676704407, -0.06512574106454849, -0.4027351438999176, -0.46190527081489563, -0.7566969394683838, -0.2976389527320862, 0.28867655992507935, -0.15881021320819855, 0.2696382999420166, -0.41135722398757935, -0.2372918576002121, 0.012652641162276268, 0.12922070920467377, 0.5777541399002075, -0.2818426489830017, -0.12705524265766144, 0.6131576299667358, -0.6801389455795288, -0.5793938636779785, 0.15064048767089844, 0.6004128456115723, -0.09154189378023148, 0.1899701952934265, -5.905003070831299, 0.10971295833587646, -0.06396915763616562, -0.3448639214038849, 0.15968778729438782, -0.49437546730041504, 0.48868775367736816, -0.14310897886753082, 0.25953391194343567, -0.27233561873435974, 0.2947007417678833, 0.22904402017593384, 0.26546362042427063, -0.18061356246471405, -0.06894730031490326, 0.13801726698875427, 0.19580022990703583, -0.5287759304046631, 1.1056466102600098, -0.06584611535072327, 0.12955862283706665, -0.5235380530357361, 0.11405786126852036, 0.1478632241487503, 0.16991908848285675, -0.2928897440433502, -0.5103522539138794, -0.22193092107772827, -0.26294583082199097, -0.22985203564167023, 0.10231649875640869, -0.5856778025627136, -0.1828010231256485, -0.12271105498075485, 0.15544094145298004, -0.4461343586444855, 0.10241624712944031, -0.3962549567222595, 0.004091720562428236, 0.023205231875181198, 0.4983404874801636, 0.30652013421058655, -0.06643369793891907, -0.28821852803230286, -0.28479713201522827, -0.06834372878074646, -0.18389134109020233, 0.2624637484550476, -0.04502154514193535, 0.7029004693031311, 0.35746756196022034, -0.2516167461872101, 0.195415198802948, 0.3183120787143707, 0.6912108063697815, 0.10254460573196411, 0.3908500075340271, 0.11492568254470825, 0.02590908110141754, 0.060686852782964706, 0.01613575778901577, -0.5543838739395142, -0.16516226530075073, -0.6662573218345642, 0.1399431973695755, 0.3595616817474365, -0.3933490514755249, -0.03571655973792076, 0.47763773798942566, -0.6276566982269287, -0.20109020173549652, -0.06322849541902542, -0.006361102219671011, -0.9088290929794312, 0.6436630487442017, -0.06967542320489883, -0.2440568059682846, 0.10276257991790771, -0.28999364376068115, -0.4760896563529968, -0.12202613055706024, -0.5411980152130127, -0.008140071295201778, -0.582980751991272, -0.03976097330451012, -0.727776288986206, -0.12425198405981064, 0.12552183866500854, -0.04040934890508652, 0.47669097781181335, 0.6314058899879456, -0.41060134768486023, 0.5335217118263245, 0.1545921415090561, 0.23726919293403625, 0.388211727142334, 0.11942265182733536, 0.26798585057258606, 0.3630746006965637, 0.24125999212265015, 0.7280236482620239, -0.3089653253555298, -0.16408781707286835, -0.3285181522369385, 0.11869707703590393, 0.381949782371521, -0.07618258893489838, 0.16045024991035461, 0.7655621767044067, -0.4571364223957062, 0.24681086838245392, -0.29249292612075806, -0.371052086353302, -0.31442469358444214, 0.8727996945381165, -0.7903763055801392, -0.20475606620311737, 0.2741817533969879, 0.6833493113517761, -0.15483766794204712, -0.04657313972711563, 0.47822022438049316, -0.7504280805587769, 0.5783832669258118, 0.020856747403740883, 0.04899757355451584, 0.1348523050546646, 0.5807598829269409, -0.5301427245140076, -0.4424092471599579, 0.046337664127349854, 0.20417390763759613, -0.31775930523872375, -0.09867898374795914, 0.18667933344841003, -0.2008536458015442, -0.516520619392395, 0.3146190643310547, 0.42914655804634094, -0.05790766328573227, -0.1505342721939087, -0.17442631721496582, -0.14001813530921936, 0.06580748409032822, 0.4656531810760498, 0.49705809354782104, 0.3875107169151306, -0.31917616724967957, -0.533001184463501, -0.05276087298989296, 0.3951205313205719, 0.05699881538748741, 0.060345396399497986, 0.2287522256374359, -0.3824639618396759, 0.21566219627857208, 0.10744225233793259, 0.15076255798339844, 0.0043815625831484795, -0.6354913711547852, 0.3123828172683716, 0.08535129576921463, -0.5124024152755737, 0.13815072178840637, -0.10517299175262451, -0.06321348994970322, 0.5641694068908691, -0.8245776295661926, -0.03436044603586197, 0.2986431419849396, -0.41140517592430115, -0.0679202526807785, 0.2862077057361603, -0.29922547936439514, -0.20177386701107025, -0.21443551778793335, -0.19873161613941193, -0.28196167945861816, 0.14583568274974823, 0.20038782060146332, 0.05709312856197357, -0.19447113573551178, 0.3364233672618866, 0.3900652229785919, -0.030370010063052177, -0.0208587609231472, -0.4234614074230194, -0.22849035263061523, -0.4189966917037964, -0.48622915148735046, 0.01645435206592083, 0.2131364494562149, 0.24976137280464172, -0.33123502135276794, -0.03468093276023865, -0.00785739067941904, 0.11308120936155319, 0.4584076702594757, -0.30415648221969604, -0.9560653567314148, 0.08432834595441818, 0.1833619922399521, -0.2525577247142792, 0.7274405360221863, 0.2615240812301636, 0.3217245638370514, 0.23025791347026825, 0.11997394263744354, 0.1202007308602333, -0.6727202534675598, -0.028413450345396996, -0.9132981896400452, 0.2136000245809555, 0.485968679189682, 0.119889996945858, -0.060697395354509354, 0.19623437523841858, -0.0907711386680603, -0.2373981922864914, 0.1029968336224556, 0.290316104888916, 0.10048734396696091, 0.24322670698165894, -0.14627784490585327, -0.7265176177024841, 0.6679986119270325, 0.7445129156112671, -0.9015373587608337, 0.3897707164287567, 0.13124051690101624, 0.30180084705352783, -0.10505940020084381, 0.17578355967998505, 0.17192862927913666, -0.8964657187461853, -0.5858690738677979, -0.6937994360923767, -0.1289128214120865, -0.3979850113391876, 0.13009294867515564, 0.20207621157169342, 0.4739398956298828, -0.5719096660614014, -0.01993577554821968, 0.18698059022426605, 0.1098153367638588, 0.009400489740073681, -0.6857768893241882, -0.19668696820735931, 0.1081724688410759, 0.18297666311264038, -0.19838295876979828, 0.10151802003383636, 0.5297921895980835, 1.0536041259765625, -0.152642622590065, -0.35064008831977844, -0.3508669435977936, -0.22409017384052277, 0.22894200682640076, -0.16943670809268951, 0.18350613117218018, -0.16236931085586548, 0.3003397583961487, -0.3878467381000519, -0.26218289136886597, -0.20025300979614258, -0.6867813467979431, 0.45614564418792725, 0.13082821667194366, -0.3683054447174072, 0.1770235151052475, 0.6882523894309998, 0.3591863512992859, -0.18123359978199005, 0.34625810384750366, -0.13526751101016998, 0.06240757927298546, 0.07954452186822891, 0.4640839993953705, -0.324305921792984, -0.4837011694908142, 0.16699224710464478, -0.3846813142299652, -0.07503305375576019, -0.3942202925682068, -0.028564488515257835, -0.333168089389801, 0.16533511877059937, 0.10991701483726501, -0.10117709636688232, -0.05542806163430214, -0.346280038356781, -0.44580286741256714, 0.2918572425842285, 0.01628161035478115, 0.3391467034816742, 0.2804315388202667, 0.2526645362377167, 0.142320916056633, -0.5669692754745483, 0.3739546239376068, 0.6158308982849121, -0.302401065826416, -0.08908312022686005, 0.15257172286510468, -0.017634129151701927, 0.12514464557170868, -0.4739953875541687, 0.08927021920681, -0.01830531656742096, -0.045273132622241974, 0.4089054465293884, -0.2544940412044525, -0.3186831772327423, 0.4362286925315857, 0.3033060133457184, 0.04028641805052757, -0.06602165102958679, 0.15067711472511292, 0.3958687484264374, 0.7018170952796936, 0.22597084939479828, -0.15384094417095184, -0.1920420527458191, 0.07874547690153122, 0.3105757534503937, -0.3268454670906067, 0.07781311124563217, 0.7711416482925415, 0.7283937335014343, -0.20550015568733215, -0.2990438640117645, 0.782219648361206, 0.20997948944568634, 0.26660189032554626, -0.17496678233146667, -0.2582465410232544, 0.07830847799777985, 0.27247315645217896, 0.9437041878700256, 0.456932008266449, 0.1857682317495346, -0.19856029748916626, 0.5632056593894958, -0.092538982629776, 0.17031677067279816, -0.30106157064437866, 0.04184570536017418, 0.2654229700565338, 0.11962307244539261, -0.4275127053260803, -0.076649971306324, 0.19718429446220398, -0.7285240292549133, 0.2697038948535919, 0.30576395988464355, 0.029828326776623726, -0.7146306037902832, 0.20906582474708557, -0.7270468473434448, -0.27837347984313965, 0.04949963092803955, 0.5503772497177124, -0.3934919238090515, 0.06889627873897552, 0.35149192810058594, 0.028096884489059448, 0.2951086759567261, 0.08981805294752121, 0.04793780669569969, -0.17255474627017975, -0.13902547955513, 0.12434308975934982, 0.2997192144393921, 0.07246469706296921, 0.18894074857234955, -0.17480066418647766, -0.05817475542426109, 0.3325551450252533, -0.23977330327033997, 0.2306811660528183, -0.36604198813438416, -0.24730512499809265, -0.35609111189842224, -0.21263475716114044, -0.34222865104675293, -0.32141175866127014, 0.2406730353832245, -0.24112769961357117, -0.01569053716957569, -0.5034645199775696, 0.386180579662323, -0.06282497942447662, 0.13523168861865997, 0.14333392679691315, -0.42326945066452026, 0.29638051986694336, 0.34556862711906433, 0.19311994314193726, 0.05418083816766739, 0.6020228266716003, -0.18928034603595734, 0.3043302595615387, -0.7736280560493469, 0.0633421316742897, -0.05054239556193352, -0.2982299327850342, -0.5436238050460815, -0.19700166583061218, 1.3666263818740845, 0.8298794031143188, -0.3093564212322235, -0.1332191824913025, -0.2766247093677521, 0.4008105993270874, 0.5108773112297058, -0.784912645816803, -0.10125456750392914, -0.7142570614814758, -0.3091277778148651, -0.7691067457199097, 0.23445695638656616, 0.029833447188138962, -0.2608644664287567, -0.21866631507873535, 0.6016367673873901, 0.5701747536659241, -0.6346120238304138, 0.47608867287635803, 0.005325804930180311, 0.14568249881267548, -0.3185674250125885, 0.1557522416114807, -0.9072685241699219, 0.2731023132801056, 0.0015229465207085013, 0.6264172196388245, -0.07739753276109695, -0.1300673633813858, 0.1407574862241745, -0.05584781616926193, 0.004040360916405916, -0.33529213070869446, -0.10167846083641052, -0.016086900606751442, 0.15393756330013275, -0.5115069150924683, -0.3849017918109894, 0.2402137666940689, 0.28826066851615906, -0.4116354286670685, 0.10992227494716644, -0.15330083668231964, 0.5281834006309509, -0.387654185295105, 0.23053157329559326, -0.30553683638572693, 0.3034965395927429, 0.08576709032058716 ]
Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is essential for coordinated cell movement. In collectively migrating human keratinocytes, FAs assemble near the leading edge, grow and mature as a result of contractile forces and disassemble underneath the advancing cell body. We report that clustering of microtubule-associated CLASP1 and CLASP2 proteins around FAs temporally correlates with FA turnover. CLASPs and LL5β (also known as PHLDB2), which recruits CLASPs to FAs, facilitate FA disassembly. CLASPs are further required for FA-associated ECM degradation, and matrix metalloprotease inhibition slows FA disassembly similarly to CLASP or PHLDB2 (LL5β) depletion. Finally, CLASP-mediated microtubule tethering at FAs establishes an FA-directed transport pathway for delivery, docking and localized fusion of exocytic vesicles near FAs. We propose that CLASPs couple microtubule organization, vesicle transport and cell interactions with the ECM, establishing a local secretion pathway that facilitates FA turnover by severing cell-matrix connections.
[ -0.012564708478748798, 0.00835923757404089, -0.00871182419359684, 0.023905951529741287, 0.009005487896502018, -0.020074713975191116, 0.009323392063379288, -0.020205385982990265, -0.011527514085173607, -0.008741221390664577, -0.017538001760840416, 0.01314811035990715, -0.011028142645955086, 0.025506015866994858, -0.03015604056417942, 0.014333286322653294, -0.006408545188605785, -0.0003909406950697303, 0.009220517240464687, 0.0141813475638628, -0.004180231597274542, -0.01809096522629261, 0.01125301979482174, -0.013853982090950012, -0.036216363310813904, -0.016604304313659668, 0.04725954681634903, 0.008055582642555237, 0.012636421248316765, 0.025421464815735817, 0.01568220928311348, -0.020951751619577408, 0.008849347941577435, 0.004327487200498581, 0.022108471021056175, 0.0024786600843071938, -0.006474634632468224, 0.02863084152340889, -0.012760613113641739, -0.0040276614017784595, -0.005002336576581001, -0.009960740804672241, 0.009681297466158867, -0.009201990440487862, -0.007963573560118675, 0.023921972140669823, -0.0053237369284033775, 0.0033843424171209335, -0.042688269168138504, 0.00811933446675539, -0.017817508429288864, -0.030399473384022713, -0.005292389541864395, -0.008266136050224304, -0.006447215564548969, -0.007706126663833857, 0.01866307109594345, -0.026476915925741196, -0.021859530359506607, -0.016464371234178543, -0.026372244581580162, -0.004509161226451397, 0.017094135284423828, 0.021025925874710083, 0.018426494672894478, -0.06660325825214386, 0.019276848062872887, 0.018651481717824936, -0.007820647209882736, -0.010014615952968597, 0.006828620098531246, 0.0031863022595643997, 0.03815734386444092, 0.007800206542015076, 0.01770784705877304, -0.025906160473823547, 0.0028403662145137787, 0.009006778709590435, -0.019744988530874252, 0.029716137796640396, -0.0013182256370782852, -0.015959767624735832, 0.01047555636614561, 0.002358492463827133, 0.005646210629492998, 0.019299741834402084, -0.019918136298656464, 0.005183944012969732, 0.008822841569781303, 0.00980905070900917, -0.009533452801406384, 0.022280775010585785, -0.024810707196593285, 0.009360406547784805, 0.0028764097951352596, -0.00009520864114165306, -0.010076457634568214, -0.02539810910820961, 0.0239248126745224, 0.01055188663303852, -0.010353795252740383, 0.0006105261854827404, 0.021665086969733238, 0.01906071975827217, 0.01562108751386404, 0.005525997839868069, 0.027904052287340164, -0.01651008613407612, 0.022354546934366226, 0.01011444441974163, -0.008702756837010384, -0.006255997810512781, -0.00807915162295103, 0.020504752174019814, 0.028554223477840424, 0.014323893934488297, -0.013152284547686577, -0.011439794674515724, 0.015111943706870079, -0.05593278631567955, 0.00859545636922121, 0.016958564519882202, 0.0004924070090055466, 0.015159070491790771, -0.0001881035277619958, -0.022926613688468933, 0.022316250950098038, 0.000027107074856758118, -0.00045800511725246906, 0.01724885031580925, -0.010722244158387184, 0.014382078312337399, -0.026565318927168846, 0.008011573925614357, 0.031305935233831406, 0.009129039943218231, -0.007937595248222351, -0.008532305248081684, -0.00526775186881423, -0.03634203225374222, 0.004783892072737217, 0.009351941756904125, 0.007789161056280136, 0.017374083399772644, 0.011599449440836906, 0.003077353350818157, -0.03064323589205742, 0.01114317774772644, 0.005109499674290419, -0.010300315916538239, 0.02010718733072281, -0.00834767334163189, -0.001167608075775206, -0.019057562574744225, -0.01048809289932251, -0.0005809455178678036, 0.003941209055483341, -0.02428978681564331, 0.00983875896781683, -0.025624677538871765, -0.033141814172267914, -0.010035453364253044, 0.021988146007061005, 0.011262351647019386, -0.014347967691719532, 0.005773946642875671, 0.004074172582477331, -0.017430704087018967, -0.020676452666521072, 0.011294391006231308, 0.007334883324801922, -0.016318630427122116, 0.010601374320685863, 0.010755075141787529, 0.001254312926903367, 0.002814273349940777, -0.004389673471450806, 0.006889199838042259, -0.024204473942518234, 0.06623106449842453, -0.0007172687910497189, 0.023406172171235085, -0.0025915526784956455, -0.013361356221139431, 0.006788069382309914, -0.03198879957199097, 0.030527357012033463, -0.015999741852283478, 0.028708722442388535, -0.030430885031819344, -0.015351329930126667, -0.024265192449092865, 0.006369829177856445, -0.00042009633034467697, -0.02064126543700695, 0.002068290254101157, -0.0028855737764388323, 0.006574529688805342, 0.010431370697915554, -0.010923370718955994, -0.028694098815321922, -0.01343496236950159, 0.03870347514748573, 0.011151183396577835, 0.02038169652223587, 0.016076885163784027, 0.0016217478550970554, 0.00047737243585288525, 0.010520700365304947, 0.02129349112510681, 0.008752917870879173, -0.005401215981692076, 0.01472863182425499, -0.008475065231323242, 0.02585001289844513, -0.007846368476748466, -0.017793141305446625, -0.018143905326724052, -0.0074814604595303535, -0.010624105110764503, 0.005428388249129057, -0.007883958518505096, -0.02688145823776722, -0.00011876039206981659, -0.0041681211441755295, 0.007302043493837118, 0.0015812492929399014, 0.012388382107019424, 0.003325400874018669, 0.0009475542465224862, -0.007578312419354916, -0.025923985987901688, -0.01429744902998209, 0.008860212750732899, 0.02802773006260395, 0.010153562761843204, 0.015968773514032364, -0.01893194392323494, 0.02497076988220215, -0.006975863128900528, 0.006906141061335802, 0.01367663312703371, 0.01568416878581047, -0.030199537053704262, 0.017682619392871857, 0.011566713452339172, -0.012613466009497643, -0.017750751227140427, 0.014519331976771355, -0.045381251722574234, 0.012454496696591377, -0.014981582760810852, -0.014492889866232872, 0.02348715253174305, 0.008021840825676918, -0.031512342393398285, 0.041731711477041245, 0.007306758780032396, 0.024928413331508636, 0.017253056168556213, -0.012881088070571423, 0.00842798687517643, -0.015746528282761574, 0.027398880571126938, -0.0010181348770856857, -0.016281889751553535, 0.006647253409028053, 0.007295073010027409, 0.009436923079192638, -0.002490755869075656, 0.010773519054055214, -0.0011217989958822727, -0.0012992569245398045, -0.0811358094215393, -0.014309868216514587, -0.017779231071472168, 0.019056063145399094, 0.0015173330903053284, 0.025860635563731194, 0.023822929710149765, -0.009718638844788074, -0.015196157619357109, 0.010693473741412163, 0.014230177737772465, -0.0007220822153612971, -0.014038536697626114, -0.024414855986833572, 0.01599716581404209, -0.007336513139307499, 0.011736293323338032, -0.022504225373268127, -0.008417947217822075, -0.014227478764951229, 0.007407220546156168, 0.009090101346373558, -0.019568966701626778, -0.010265178047120571, 0.008991549722850323, 0.011318626813590527, 0.016269061714410782, -0.0031360762659460306, 0.001834658905863762, 0.017515480518341064, -0.0038309379015117884, 0.013807962648570538, -0.014629731886088848, 0.015803195536136627, 0.013141966424882412, 0.031346507370471954, 0.0033054875675588846, -0.028626687824726105, -0.014890890568494797, 0.028627824038267136, -0.002395839896053076, 0.015584850683808327, 0.005819450598210096, 0.02477065473794937, -0.004071271046996117, -0.002932169707491994, 0.013375451788306236, -0.019947286695241928, 0.024488117545843124, 0.00082563073374331, -0.0035777983721345663, -0.008441390469670296, 0.016889803111553192, 0.01812661439180374, -0.027651453390717506, -0.008027708157896996, -0.0012604594230651855, 0.023687856271862984, -0.015680354088544846, -0.015129243955016136, -0.010934857651591301, -0.01645990088582039, -0.003645516000688076, -0.005650154780596495, -0.025347348302602768, 0.016078418120741844, 0.016479339450597763, 0.006131159141659737, -0.009189981035888195, 0.008897874504327774, 0.021814823150634766, -0.010660865344107151, -0.007374306209385395, -0.012195932678878307, -0.010197928175330162, -0.018577691167593002, -0.015031727030873299, 0.0035555041395127773, 0.002416077069938183, -0.03352920711040497, -0.028609242290258408, -0.010090779513120651, -0.011894474737346172, 0.0015823420835658908, -0.01601666957139969, -0.04248031601309776, 0.0038060550577938557, 0.043898820877075195, 0.02158525586128235, -0.02063414454460144, -0.005300566554069519, -0.021492749452590942, 0.012656236067414284, 0.008697266690433025, -0.012057720683515072, 0.006885170005261898, 0.015267388895154, -0.01718001812696457, -0.0364769846200943, 0.009497740305960178, -0.02164500579237938, 0.000583035172894597, -0.01538960449397564, -0.009246563538908958, -0.012955591082572937, 0.015428436920046806, 0.003578034695237875, -0.029930397868156433, 0.01592376083135605, -0.0026983143761754036, -0.027179669588804245, -0.01132960245013237, 0.0008651934331282973, 0.0008491110056638718, 0.009653517976403236, 0.03115929290652275, -0.012764671817421913, -0.011119257658720016, 0.07227639853954315, -0.0016935702878981829, -0.00825736578553915, 0.0027567241340875626, 0.007553355768322945, -0.03191492706537247, 0.0006859246641397476, 0.005877955351024866, 0.008282382041215897, 0.01163740735501051, 0.012496287934482098, -0.02109323814511299, -0.014923721551895142, 0.04019256681203842, -0.03764575719833374, -0.013310945592820644, -0.025330953299999237, -0.03257492929697037, 0.0006283102557063103, -0.007186334114521742, 0.010496322065591812, -0.010801725089550018, 0.008121275343000889, -0.03415247052907944, 0.0015823733992874622, -0.025734059512615204, 0.010245481505990028, -0.0130660030990839, -0.020234964787960052, 0.012596938759088516, 0.018651016056537628, 0.020908895879983902, -0.007556868717074394, -0.006343361921608448, 0.01723666675388813, -0.002837227191776037, 0.009333794936537743, -0.00562723632901907, 0.0027453163638710976, -0.0039222752675414085, -0.004869258962571621, -0.01780647784471512, -0.0006825800519436598, 0.01439276710152626, 0.01992771402001381, -0.04263835772871971, 0.009607726708054543, -0.01312769390642643, -0.004135461989790201, -0.012548783794045448, -0.02711055800318718, 0.01244083046913147, 0.011578299105167389, 0.013639316894114017, 0.009844762273132801, 0.009289372712373734, 0.0038527781143784523, -0.01544158160686493, -0.020251857116818428, 0.0018844567239284515, -0.023878823965787888, 0.030665624886751175, -0.003119293600320816, -0.02900899574160576, -0.028697842732071877, -0.012883028015494347, 0.00012039951980113983, 0.01221674308180809, -0.008862748742103577, 0.0038327760994434357, 0.024109724909067154, -0.009466818533837795, 0.0206346046179533, 0.0034454136621207, -0.0029655497055500746, -0.008212198503315449, 0.002704869257286191, -0.02253434620797634, 0.02669159695506096, 0.014107942581176758, 0.009897720068693161, -0.02611471340060234, -0.025666095316410065, -0.030781041830778122, -0.03676798194646835, -0.026331167668104172, -0.017925772815942764, -0.07427314668893814, -0.01361991185694933, 0.0038136520888656378, -0.00834839977324009, -0.019547997042536736, -0.012655604630708694, -0.018380938097834587, -0.01708585023880005, 0.010053058154881, 0.0007353461114689708, 0.027357233688235283, 0.00958195049315691, 0.03432978317141533, -0.0007434323197230697, 0.012341009452939034, -0.019963547587394714, -0.016155213117599487, 0.0002112537040375173, -0.03537008538842201, -0.01839042827486992, 0.019889479503035545, 0.012717237696051598, -0.021734431385993958, -0.005324686877429485, -0.007135341409593821, -0.08136335015296936, -0.007141184993088245, 0.019155751913785934, -0.02931453101336956, -0.005922771990299225, 0.005977945402264595, -0.010022655129432678, -0.03259539604187012, 0.017250843346118927, -0.017235249280929565, -0.01060530636459589, -0.010085378773510456, -0.016380421817302704, 0.002373801078647375, 0.01254432462155819, -0.008908769115805626, 0.025187304243445396, -0.030912909656763077, 0.002324503380805254, -0.008374258875846863, 0.017298756167292595, 0.030208010226488113, -0.016683725640177727, 0.007885060273110867, -0.00948377512395382, -0.022881167009472847, -0.022425226867198944, 0.007607579231262207, 0.02180570736527443, 0.0071382587775588036, -0.012607217766344547, 0.030362293124198914, -0.007009441964328289, -0.0041080983355641365, -0.01376710832118988, -0.01874726638197899, -0.014025283977389336, -0.010677149519324303, 0.03424070030450821, -0.010923377238214016, -0.004464450757950544, -0.019728589802980423, -0.007202526554465294, -0.003704123431816697, -0.011843590065836906, 0.007851071655750275, 0.00446654949337244, -0.009180312976241112, 0.017825929448008537, -0.009335719048976898, 0.0155393797904253, -0.017978830263018608, -0.020434213802218437, 0.0024950162041932344, 0.01689642295241356, -0.0010174792259931564, 0.0011824928224086761, 0.003303767181932926, 0.006412037648260593, -0.0010704058222472668, 0.0018720254302024841, 0.006829601246863604, 0.0019327375339344144, 0.07121656835079193, -0.010345797054469585, 0.009705650620162487, 0.0052908193320035934, -0.012917152605950832, 0.0006902017630636692, -0.011485607363283634, 0.03442315757274628, 0.010099446401000023, -0.03268195688724518, -0.011989032849669456, -0.015546426177024841, 0.001292047556489706, 0.018081601709127426, -0.0035841979552060366, 0.02132127434015274, -0.004220018163323402, -0.0029372244607657194, -0.026116706430912018, 0.00264012161642313, -0.02184857241809368, 0.02242458611726761, 0.0031288182362914085, 0.011217368766665459, 0.014727686531841755, 0.011502625420689583, -0.011553550139069557, 0.03407720848917961, -0.012494577094912529, -0.012401295825839043, 0.001382764894515276, 0.01726541481912136, 0.001198275713250041, -0.0341191403567791, 0.020524492487311363, 0.01667836867272854, 0.011568098329007626, 0.00874455738812685, -0.02063232846558094, -0.006111850030720234, 0.010028211399912834, 0.0010272613726556301, -0.0064651560969650745, 0.01464657299220562, -0.004232867155224085, -0.00633152574300766, 0.0036880692932754755, 0.009963514283299446, -0.041808489710092545, 0.012250839732587337, 0.001782068982720375, 0.0004909528070129454, 0.0054714260622859, -0.021199136972427368, 0.026936911046504974, 0.009704574942588806, 0.0061799767427146435, 0.01895080879330635, -0.016783010214567184, -0.020615864545106888, -0.012395604513585567, -0.016070928424596786, -0.016895925626158714, -0.01336460281163454, 0.029003994539380074, -0.011664880439639091, 0.02549632638692856, -0.006855017505586147, -0.018854260444641113, 0.01802583411335945, -0.021834930405020714, 0.0030931755900382996, 0.011274328455328941, -0.005745498463511467, 0.0130337318405509, 0.003858232405036688, -0.002083747647702694, -0.016973290592432022, 0.012544252909719944, 0.01885051652789116, -0.015567351132631302, 0.0571315735578537, 0.017573442310094833, -0.001915795262902975, -0.00911225937306881, 0.020325154066085815, -0.01177678070962429, 0.01441965065896511, -0.007161927409470081, 0.00794147327542305, 0.011940233409404755, -0.007182257249951363, -0.0027823783457279205, 0.027406271547079086, 0.009839707985520363, 0.034007783979177475, 0.0005288897082209587, -0.0025692202616482973, 0.03967517986893654, 0.006113335024565458, 0.019132638350129128, -0.020421281456947327, -0.013896094635128975, -0.01373667549341917, 0.009857259690761566, -0.007695471867918968, 0.0001973563339561224, -0.026720978319644928, 0.00397907430306077, 0.019679460674524307, 0.006873289588838816, -0.016665279865264893, 0.027801722288131714, -0.004131035879254341, -0.0058350940234959126, 0.032038308680057526, -0.01911964640021324, 0.027722518891096115, -0.005515328608453274, -0.012155194766819477, 0.005361116956919432, -0.0038583928253501654, -0.027492690831422806, -0.008865265175700188, -0.008633910678327084, -0.007150501012802124, -0.01045188121497631, 0.010269615799188614, -0.009588915854692459, -0.005845269653946161, 0.019203420728445053, -0.011569427326321602, 0.016748663038015366, -0.003515704069286585, 0.004063275642693043, -0.027132228016853333, 0.014804558828473091, 0.0011283948551863432, -0.01219167746603489, 0.012581381015479565, 0.007048748899251223, -0.02635885402560234, 0.002936460543423891, 0.01477821171283722, 0.0067350175231695175, -0.014891006983816624, 0.013933136127889156, -0.007690731436014175, 0.017739273607730865, -0.0072312792763113976, -0.000955953961238265, -0.0025778955314308405, -0.0019403067417442799, -0.006949294358491898, -0.010431814007461071, 0.009887194260954857, 0.007455568294972181, 0.0026721511967480183, -0.0016673840582370758, -0.00398988788947463, 0.0006045983172953129, 0.004450276494026184, -0.021143034100532532, -0.004248224664479494, 0.020047206431627274, 0.03310547024011612, 0.01001662015914917, 0.01836657151579857, -0.0371064618229866, -0.006797621957957745, -0.011619260534644127, 0.02654751017689705, -0.01623562164604664, 0.002065676962956786, -0.00914907455444336, -0.013933672569692135, -0.009572777897119522, -0.0014540269039571285, -0.0006948886439204216, 0.005166364833712578, 0.0004634576616808772, -0.03470996767282486, -0.001678313361480832, -0.01309671439230442, -0.002298687817528844, 0.002086465246975422, -0.0004033192526549101, -0.020023705437779427, 0.00817851535975933, 0.028708960860967636, 0.000010145595297217369, 0.0016718716360628605, -0.02008228749036789, 0.009775436483323574, -0.021680770441889763, 0.016493741422891617, 0.012658633291721344, 0.002629084512591362, -0.0011147852055728436, 0.015529085882008076, -0.006282626185566187, -0.016291018575429916 ]
[ -0.2696596086025238, -0.13335752487182617, 0.842968761920929, -0.10379522293806076, -0.03320833668112755, 0.23978137969970703, -0.003841887228190899, -0.33544689416885376, -0.43900811672210693, -0.5985299944877625, -0.15384581685066223, -0.21558304131031036, -0.3737642467021942, 0.03590844199061394, 0.23252533376216888, 0.5474853515625, 0.2748541235923767, 0.2974223792552948, -0.11521143466234207, -0.6168675422668457, -0.19888857007026672, -0.3050892651081085, 0.27468422055244446, 0.18936240673065186, 0.19882631301879883, -0.4830082654953003, 0.1787550449371338, -0.279153048992157, 0.467014878988266, -0.4533761739730835, -0.3647724986076355, 0.2532568573951721, 0.07403097301721573, 0.059682462364435196, -0.1672932207584381, 0.237284854054451, 0.07237580418586731, -0.24591876566410065, 0.08190096914768219, -0.2037709504365921, -0.4856788218021393, 0.11205147206783295, -0.13288447260856628, 0.48058730363845825, -0.2004919797182083, -0.15304167568683624, -1.488649845123291, 0.5990394353866577, -0.19961901009082794, -0.18247073888778687, -0.3648954927921295, 0.37140974402427673, 0.5500627756118774, -0.1452641785144806, 0.20720785856246948, -0.14465907216072083, -0.8835983276367188, -0.2904347777366638, 0.528811514377594, -0.8445391058921814, 0.46873030066490173, 0.10979005694389343, -0.11116619408130646, 0.013924453407526016, -0.10162945836782455, 0.4613889455795288, 0.22098711133003235, -0.21543926000595093, -0.4272555708885193, 0.002688806736841798, -0.017682047560811043, -0.0035999075043946505, -0.41036781668663025, 0.09037462621927261, -0.1314636766910553, -0.20697587728500366, -0.2410837709903717, -0.19650375843048096, 0.2057514786720276, -0.08053899556398392, -0.3302452266216278, 0.0646168664097786, 0.4815933108329773, 0.12009583413600922, 0.7706204652786255, 0.3023318648338318, -0.34888511896133423, 0.42284560203552246, -0.5173527002334595, 0.050075653940439224, -0.217396542429924, -0.3003702461719513, 0.5068692564964294, 0.08753467351198196, 0.35967689752578735, 0.29673638939857483, 0.41777360439300537, -0.04023845121264458, 0.1193048357963562, 0.32405415177345276, -0.10180489718914032, 0.30394303798675537, -0.48266535997390747, -0.33786237239837646, 0.15826503932476044, -0.43067020177841187, -0.3377407491207123, -0.497111439704895, -0.21169567108154297, -0.13592036068439484, -1.0079491138458252, -0.6346741914749146, -0.39601144194602966, -0.3422974646091461, 0.5138566493988037, 0.0023805347736924887, 0.0252683088183403, -0.41780537366867065, -0.16806720197200775, 0.1251331865787506, -0.03546830266714096, 1.1552343368530273, -0.23746135830879211, 0.22161997854709625, -0.4628995358943939, -0.20255598425865173, 0.19301952421665192, -0.12033459544181824, -0.5699449181556702, 0.6222348809242249, -0.036562301218509674, 0.5231403112411499, -0.36422884464263916, 0.04038883000612259, 0.21410980820655823, -0.15867078304290771, 0.32308346033096313, 0.4880552589893341, 0.4638470411300659, 0.1846221387386322, -0.38534533977508545, -0.30713844299316406, -0.47907328605651855, 0.007414736784994602, 0.17234455049037933, -0.39876559376716614, -0.47063007950782776, -0.14331631362438202, -0.011759056709706783, -0.10959500074386597, 0.00029843460652045906, 0.0584624707698822, -0.4839285910129547, 0.1895783692598343, -0.31786832213401794, 0.6168377995491028, 0.37159308791160583, -0.3209139108657837, 0.20320233702659607, 0.29886555671691895, 0.03240419551730156, -0.10749159008264542, -0.39978381991386414, -0.032430581748485565, 0.2221565544605255, 0.20919111371040344, 0.613456666469574, 0.35396429896354675, 0.23847483098506927, 0.08876679092645645, -0.12588445842266083, -0.06350483000278473, 0.2750339210033417, -0.34936192631721497, -0.3397599756717682, 0.04402972385287285, 0.2190432846546173, -0.01352720521390438, -0.15499746799468994, -0.12007923424243927, -0.6670444011688232, -0.27421823143959045, -0.2351125031709671, -0.5240349769592285, 0.5321356654167175, 0.1768094152212143, 0.19257569313049316, -0.18968433141708374, -0.18070214986801147, -0.002489938400685787, 0.6388831734657288, -0.13388389348983765, 0.635172963142395, -0.6384475231170654, 1.2117191553115845, -0.3749362826347351, -0.3524624705314636, 1.0283849239349365, 0.2360890656709671, -0.26144522428512573, -0.22281302511692047, 0.03452548012137413, 0.23861812055110931, -0.23330429196357727, 0.213369682431221, 0.331281453371048, -0.3915860950946808, 0.178604394197464, 0.11097582429647446, 0.10123136639595032, 0.023088976740837097, -0.6374214291572571, -0.08131943643093109, -0.12750770151615143, 0.7168266177177429, -0.8550287485122681, -0.20580774545669556, -0.2667381465435028, -0.6553347110748291, 0.06635471433401108, 0.4543468952178955, -0.40523990988731384, 0.18263763189315796, 0.9444304704666138, -0.009223945438861847, 0.2485051453113556, 0.5672615170478821, 0.17461614310741425, 0.6669143438339233, -0.30533188581466675, 0.32617658376693726, -0.2051316648721695, 0.13255594670772552, -0.4439299404621124, 0.008954777382314205, 0.01772996038198471, 0.2763442397117615, -0.4364379048347473, -0.38008251786231995, -0.30378100275993347, -0.3609525263309479, 0.6346011161804199, -0.21500228345394135, 0.04869932681322098, -0.06453894078731537, -0.49244290590286255, 0.29307541251182556, 0.4793398082256317, -0.9371880888938904, 0.10706145316362381, 0.2262127697467804, 0.4646422564983368, 0.2415000945329666, -0.6538807153701782, 0.3490101099014282, -0.2721601128578186, -0.08670049905776978, -0.2944088876247406, -0.07543238997459412, -0.19239190220832825, 0.1713334619998932, -0.26386988162994385, -0.0773109495639801, 0.4343726933002472, -0.16353236138820648, -0.32923638820648193, -0.41482850909233093, -0.19437846541404724, 1.1478890180587769, 0.34401464462280273, 0.8960684537887573, -0.25947272777557373, -0.3413783609867096, 0.043223701417446136, -0.08628721535205841, -0.23156426846981049, 0.14988279342651367, 0.03168506175279617, -0.23342321813106537, -0.15911972522735596, -0.05648531764745712, -0.12188483029603958, 0.8554621934890747, 0.11203879863023758, -0.13650044798851013, -0.0059194122441112995, -0.12073834985494614, -0.017874933779239655, 0.006669019348919392, -0.33218932151794434, -0.003909716382622719, 0.2084013670682907, 0.03344492241740227, -0.40885305404663086, -0.038035016506910324, 0.4444027841091156, -0.3239806294441223, 0.6822870373725891, 0.43769553303718567, -0.07015179842710495, -0.35008347034454346, 0.2774368226528168, -0.06839350610971451, -0.3441586196422577, 0.08976254612207413, -0.2049289047718048, -0.6187717914581299, 0.1921125054359436, -6.018550872802734, 0.24755549430847168, -0.051229048520326614, -0.10412599891424179, 0.09334313124418259, -0.2794955372810364, 0.7208697199821472, 0.20076951384544373, 0.13576802611351013, 0.05418747290968895, 0.06943173706531525, 0.06798212975263596, -0.4643886387348175, 0.3196519613265991, -0.39686575531959534, 0.3310876786708832, -0.1296021044254303, -0.08958718180656433, 0.34571513533592224, -0.06477341800928116, -0.11840195208787918, -0.6254326701164246, 0.09862905740737915, 0.38347262144088745, -0.02301168628036976, -0.27216628193855286, -1.0509127378463745, -0.08541440218687057, 0.12861283123493195, -0.09857121855020523, -0.25015273690223694, -0.34062865376472473, -0.0001855535083450377, -0.13112451136112213, 0.6596747040748596, 0.11863692849874496, 0.029031027108430862, 0.1599455028772354, -0.13519088923931122, -1.0122185945510864, 0.6579629778862, 0.38548561930656433, -0.412004679441452, 0.2060796022415161, 0.259443998336792, -0.009760553017258644, -0.2940523028373718, 0.3576974868774414, -0.5635942816734314, 0.5118691921234131, -0.11858732998371124, -0.33187922835350037, 0.12391433864831924, 0.08758246153593063, 0.5783606767654419, 0.08015703409910202, 0.009501866064965725, -0.41618072986602783, -0.44251954555511475, 0.14686819911003113, -0.1787825971841812, -0.2679070234298706, -0.23685424029827118, -0.41566234827041626, -0.044119976460933685, 0.42518195509910583, -0.9560440182685852, -0.3183235824108124, 0.6452609896659851, -0.20849598944187164, -0.2739470899105072, 0.36752402782440186, -0.004072308074682951, -0.6499439477920532, 0.647906482219696, -0.2847638428211212, 0.5568308234214783, 0.14283381402492523, 0.15601623058319092, 0.08004885911941528, -0.0944666638970375, 0.010568101890385151, 0.3179812729358673, -0.18109814822673798, -0.18505656719207764, -0.05120915174484253, 0.1174219623208046, 0.03694969043135643, -0.2819857597351074, 0.5417417287826538, 0.20185677707195282, 0.0390419103205204, 0.15945494174957275, 0.4937191903591156, 0.028500504791736603, 0.064545176923275, 0.11940968036651611, 0.415295273065567, 0.3638871908187866, -0.21463799476623535, 0.9115244150161743, -0.3415584862232208, -0.39647993445396423, -0.2541719079017639, 0.18532079458236694, 0.5285980105400085, -0.40944868326187134, 0.33488234877586365, 0.6191941499710083, -0.39681923389434814, 0.3256099224090576, 0.17757247388362885, -0.5728703737258911, -0.5786958932876587, 0.475216805934906, -0.1559140682220459, -0.4977068305015564, 0.1084568127989769, 0.28605154156684875, -0.3347736895084381, -0.08700810372829437, 0.1077672615647316, -0.4565148949623108, 0.5449340343475342, -0.11857026815414429, 0.19077029824256897, -0.0727144107222557, 0.8341811895370483, -0.4895347058773041, -0.13326318562030792, 0.4034484326839447, 0.32616958022117615, -0.1716904491186142, 0.21987862884998322, 0.259075790643692, -0.920466959476471, 0.036532580852508545, 0.3585357069969177, 0.5001596808433533, -0.4907742440700531, 0.5536118149757385, -0.16220137476921082, -0.21608500182628632, -0.0809582844376564, -0.10560542345046997, 0.12612096965312958, -0.13236917555332184, 0.6340461373329163, -0.242886021733284, -0.05738129839301109, 0.5685443878173828, -0.5683128237724304, -0.16544829308986664, 0.16553540527820587, -0.31036972999572754, 0.002236240077763796, 0.38983017206192017, 0.09761413931846619, 0.5295408964157104, -0.5731490850448608, -0.03892486169934273, 0.23586317896842957, -0.8399398922920227, -0.13937784731388092, -0.6109766364097595, -0.2922164797782898, -0.3146877884864807, -0.5785436630249023, -0.08164960891008377, -0.023189732804894447, -0.2094394564628601, -0.1497901827096939, -0.331240177154541, -0.5055879950523376, -0.041742585599422455, -0.32579970359802246, -0.45024368166923523, 0.11196829378604889, 0.04163890704512596, -0.040712352842092514, -0.0944833979010582, -0.27348649501800537, -0.325596421957016, -0.10799754410982132, 0.08886400610208511, -0.14896252751350403, 0.3191070854663849, -0.20569805800914764, 0.07056577503681183, -0.4909763038158417, 0.5064009428024292, 0.24709467589855194, 0.03472820669412613, -0.17169933021068573, 0.48751237988471985, 0.2349877506494522, 0.3426818251609802, 0.7199545502662659, -0.19864709675312042, -0.28149476647377014, 0.09919066727161407, 0.41601425409317017, -0.3741096258163452, 0.49348872900009155, 0.5332270264625549, 0.23600251972675323, 0.04198445379734039, 0.006648159585893154, -0.17663702368736267, -0.0853385180234909, 0.20119887590408325, -0.17697472870349884, -0.17294661700725555, 0.23023253679275513, 0.03543205186724663, -0.03968048840761185, 0.0008766866521909833, -0.3666899800300598, -0.40412694215774536, 0.6852612495422363, 0.2776103615760803, -0.004093082156032324, 0.03749840706586838, -0.09164053201675415, -0.428354412317276, 0.13594533503055573, 0.2806813418865204, -0.5884114503860474, 0.17134493589401245, 0.2550194561481476, 0.037589870393276215, -0.3731493055820465, -0.14203600585460663, 0.22275452315807343, -0.33984091877937317, -0.4536741077899933, -0.5993726253509521, -0.10325050354003906, 0.05969519540667534, 0.4686706066131592, -0.02990042231976986, 0.6467337608337402, -0.18586432933807373, -0.3690964877605438, -0.05851477012038231, 0.4084084928035736, 0.22203488647937775, -0.8063124418258667, 0.07472383230924606, 0.1026371493935585, 0.5793763995170593, -0.20779334008693695, 0.27306580543518066, 0.6221418380737305, 0.6614536643028259, 0.258070170879364, -0.41080358624458313, -0.18004801869392395, 0.04294074699282646, 0.14041827619075775, -0.081326924264431, -0.11084675043821335, -0.0063703362829983234, 0.022117801010608673, -0.15916916728019714, -0.04083388298749924, -0.07166431099176407, -0.520308256149292, 0.3919229805469513, -0.1653619110584259, 0.019926074892282486, -0.14012984931468964, 0.6520102024078369, 0.1437608301639557, 0.14958876371383667, 0.06325824558734894, 0.02919113077223301, 0.28281134366989136, 0.14954274892807007, 0.15637412667274475, -0.20679715275764465, -0.9388300180435181, 0.119355708360672, -0.1979624330997467, 0.710803210735321, -0.7757306694984436, 0.2693302035331726, -0.5610702037811279, 0.002693124348297715, 0.12228049337863922, -0.08595359325408936, 0.30538707971572876, -0.4147662818431854, -0.3939870297908783, -0.12168750911951065, 0.4695611596107483, 0.5354199409484863, 0.3565712869167328, -0.016481591388583183, 0.35055801272392273, -0.5508212447166443, 0.3633415699005127, 0.010746575891971588, -0.6213990449905396, -0.23379848897457123, -0.11161163449287415, -0.3296910226345062, -0.11613151431083679, -0.7486409544944763, 0.1701899617910385, 0.1359892040491104, -0.36900949478149414, 0.6155152320861816, 0.03742536902427673, -0.17390504479408264, -0.08885867148637772, 0.1942698210477829, -0.33027613162994385, 0.35711875557899475, 0.562578558921814, 0.07642949372529984, 0.8367170691490173, 0.32257014513015747, -0.0016602956457063556, 0.09215597808361053, 0.38218486309051514, 0.3754138648509979, 0.5994142889976501, -0.15989741683006287, 0.5537527203559875, 0.6206691265106201, 0.32881471514701843, 0.1492934674024582, 0.592382550239563, 0.689530611038208, -0.1606847643852234, 0.14422371983528137, -0.5331779718399048, -0.3130488991737366, -0.024562014266848564, 0.5668736696243286, 0.8421321511268616, -0.17163576185703278, -0.2624703645706177, 0.15650233626365662, -0.03211017698049545, 0.12711304426193237, 0.2206287831068039, -0.33819901943206787, 0.42317256331443787, 0.591644287109375, -0.5471502542495728, -0.28070101141929626, 0.07869736850261688, -0.431117445230484, 0.014923114329576492, 0.7928868532180786, -0.4619564712047577, -0.3944728970527649, 0.3154577612876892, -0.4969888925552368, 0.4138805568218231, 0.04562080278992653, 0.5568141341209412, 0.02116868644952774, -0.3657492697238922, 0.5236777663230896, 0.008427752181887627, 0.5230324268341064, -0.015073627233505249, 0.16692622005939484, 0.5164651274681091, -0.16769257187843323, 0.40922075510025024, 0.1982761025428772, -0.4905998408794403, -0.04424089565873146, -0.02375667728483677, 0.11518129706382751, 0.30688250064849854, -0.3713850677013397, 0.6739163994789124, 0.17221231758594513, -0.5786882638931274, -0.17929334938526154, -0.17429772019386292, 0.045371782034635544, -0.20513109862804413, -0.03486214205622673, 0.2343873381614685, -0.15278229117393494, -0.747428297996521, 0.2579890787601471, -0.13831138610839844, 0.1488218903541565, 0.2411518543958664, 0.2297528088092804, 0.41094842553138733, 0.6379866003990173, 0.4743902385234833, -0.1602616310119629, 0.5759063959121704, -0.2841185927391052, 0.13111600279808044, -0.2537012994289398, 0.4416857659816742, -0.5346016883850098, -0.40514299273490906, -0.18084411323070526, 0.04184791445732117, 0.8744668364524841, 0.663493812084198, -0.5440685153007507, 0.35178011655807495, 0.5391968488693237, 0.43401890993118286, 0.13719414174556732, -0.5693792104721069, -0.28733858466148376, -0.6759624481201172, -0.08669853210449219, -0.46828991174697876, 0.6508809328079224, 0.0012430442729964852, -0.18834611773490906, -0.22837723791599274, 0.371925413608551, 0.2449878454208374, -0.07374679297208786, 0.44274967908859253, -0.43972980976104736, -0.19613631069660187, -0.5432746410369873, 0.09080196917057037, -0.45070791244506836, 0.2647377848625183, -0.8464747667312622, -0.05114263668656349, 0.44128692150115967, -0.40145811438560486, 0.55015629529953, 0.032212212681770325, 0.10864301770925522, -0.13799887895584106, 0.5502262711524963, -0.008176579140126705, -0.5073476433753967, -0.8091015219688416, -0.6304052472114563, 0.07275863736867905, 0.46850866079330444, -0.6575188040733337, -0.20035327970981598, -0.2003955990076065, 0.05672464147210121, -0.06633434444665909, -0.19575828313827515, -0.17683303356170654, -0.14574170112609863, -0.040670596063137054 ]
BACKGROUND Production of the GTP-bound form of the Ran GTPase (RanGTP) around chromosomes induces spindle assembly by activating nuclear localization signal (NLS)-containing proteins. Several NLS proteins have been identified as spindle assembly factors, but the complexity of the process led us to search for additional proteins with distinct roles in spindle assembly. RESULTS We identify a chromatin-remodeling ATPase, CHD4, as a RanGTP-dependent microtubule (MT)-associated protein (MAP). MT binding occurs via the region containing an NLS and chromatin-binding domains. In Xenopus egg extracts and cultured cells, CHD4 largely dissociates from mitotic chromosomes and partially localizes to the spindle. Immunodepletion of CHD4 from egg extracts significantly reduces the quantity of MTs produced around chromatin and prevents spindle assembly. CHD4 RNAi in both HeLa and Drosophila S2 cells induces defects in spindle assembly and chromosome alignment in early mitosis, leading to chromosome missegregation. Further analysis in egg extracts and in HeLa cells reveals that CHD4 is a RanGTP-dependent MT stabilizer. Moreover, the CHD4-containing NuRD complex promotes organization of MTs into bipolar spindles in egg extracts. Importantly, this function of CHD4 is independent of chromatin remodeling. CONCLUSIONS Our results uncover a new role for CHD4 as a MAP required for MT stabilization and involved in generating spindle bipolarity.
[ -0.002727240091189742, -0.00000367569737136364, 0.0013731814688071609, 0.023550264537334442, -0.012259047478437424, -0.0013233785284683108, 0.010807028040289879, -0.0007647337624803185, -0.009173912927508354, 0.01834825798869133, -0.006062280386686325, -0.0010168789885938168, -0.007132920436561108, 0.020891312509775162, 0.01875496283173561, -0.02332226373255253, -0.018904684111475945, 0.007934708148241043, 0.009642843157052994, 0.02802489697933197, -0.004394587595015764, -0.010762890800833702, 0.009658794850111008, -0.0015331786125898361, 0.027297772467136383, 0.006469157058745623, 0.030026234686374664, -0.005109530873596668, -0.026615750044584274, 0.02080276794731617, 0.0042709531262516975, 0.0010670588817447424, 0.026784460991621017, 0.002066836692392826, -0.006663711741566658, 0.015648894011974335, -0.009642455726861954, 0.024349957704544067, 0.04448843002319336, -0.00698908232152462, 0.00031000771559774876, -0.01451321505010128, -0.005237407051026821, -0.0025324421003460884, -0.010973870754241943, 0.014660883694887161, -0.0011735539883375168, 0.016343779861927032, -0.013041004538536072, 0.002925909822806716, -0.017496000975370407, 0.011102361604571342, 0.00018404342699795961, 0.028272703289985657, -0.006451774388551712, -0.024068614467978477, 0.016680913046002388, 0.016621006652712822, -0.020734159275889397, -0.01174303237348795, -0.004886861424893141, 0.03612937033176422, -0.026212088763713837, 0.01667509414255619, 0.006808334495872259, -0.06705231964588165, 0.017698751762509346, -0.02047182433307171, -0.004278254695236683, 0.005792957730591297, -0.008936275728046894, 0.01036817766726017, -0.005652821622788906, -0.021855702623724937, -0.0078973937779665, 0.004571136552840471, -0.02578841522336006, -0.006163681857287884, 0.010302402079105377, 0.008929063566029072, -0.002010311931371689, -0.01002576481550932, -0.021567046642303467, -0.003115555737167597, -0.0055870357900857925, 0.010481910780072212, -0.017199749127030373, -0.015388176776468754, 0.007819313555955887, 0.017942439764738083, 0.0159124955534935, -0.0037994373124092817, -0.0002702055498957634, 0.012494675815105438, 0.006678145378828049, -0.018786590546369553, 0.006235390901565552, -0.03917200118303299, 0.021780043840408325, -0.0022437204606831074, -0.011706136167049408, 0.002118047559633851, 0.022029824554920197, -0.014317702502012253, 0.02089390531182289, 0.0041340976022183895, 0.030366254970431328, 0.02595585770905018, 0.013875207863748074, 0.009859856218099594, -0.003123050555586815, 0.033819906413555145, -0.0182783380150795, 0.032297246158123016, 0.003750697709619999, 0.014122458174824715, -0.02397102490067482, -0.0018901885487139225, 0.011701852083206177, -0.01854284666478634, 0.017725709825754166, 0.018625402823090553, -0.010710948146879673, 0.011563913896679878, 0.006120048463344574, -0.004669284448027611, 0.0012785177677869797, 0.010920187458395958, -0.010545512661337852, 0.0229942686855793, -0.01217895932495594, -0.0017595610115677118, -0.026249632239341736, 0.015223817899823189, -0.009620262309908867, -0.007665218785405159, -0.014864424243569374, -0.0014504524879157543, -0.0022347387857735157, -0.0020881672389805317, 0.016694102436304092, 0.009705313481390476, 0.0078111025504767895, 0.013720906339585781, 0.010347921401262283, 0.020318202674388885, 0.004129920620471239, 0.0074626849964261055, -0.009601262398064137, -0.0277848020195961, 0.024578193202614784, 0.02041221410036087, 0.0011613569222390652, -0.017085697501897812, 0.0303560309112072, 0.009149197489023209, -0.013298305682837963, -0.022261131554841995, -0.021599069237709045, 0.014288224279880524, 0.01147281564772129, -0.007691851817071438, 0.016363203525543213, 0.009199842810630798, -0.013187834993004799, -0.03476002812385559, 0.016464967280626297, -0.018650971353054047, -0.015786536037921906, 0.004799860529601574, -0.005245172418653965, 0.019032081589102745, 0.022034399211406708, 0.011953882873058319, -0.030672386288642883, 0.003943877760320902, -0.01593572460114956, 0.008340561762452126, -0.02405296452343464, 0.06648226082324982, -0.019975025206804276, 0.025384608656167984, 0.009080130606889725, -0.017019985243678093, 0.01660236343741417, -0.01997690461575985, 0.02892080694437027, -0.0036478962283581495, -0.017462797462940216, -0.00392046058550477, -0.0014158171834424138, 0.00708833197131753, -0.004082855768501759, 0.0037167067639529705, 0.007404188625514507, 0.0022255736403167248, 0.021959031000733376, -0.008712378330528736, 0.016818895936012268, -0.011355896480381489, 0.006645265966653824, -0.03098488785326481, 0.01251501776278019, 0.0005288966931402683, 0.007048602215945721, 0.0026811135467141867, 0.015764497220516205, 0.012844985350966454, 0.01839880831539631, 0.016200417652726173, 0.01174828503280878, -0.007279886864125729, 0.002028209622949362, -0.016426710411906242, -0.01810753345489502, -0.013121765106916428, -0.02107890136539936, 0.015550287440419197, 0.005980969872325659, -0.009837567806243896, -0.0012954318663105369, -0.015654172748327255, 0.0008536698296666145, -0.026252835988998413, 0.029158659279346466, -0.007913658395409584, -0.000025820918381214142, 0.012323166243731976, -0.026496820151805878, -0.01469016820192337, 0.013602839782834053, -0.017891088500618935, -0.016014017164707184, 0.01664748415350914, 0.030107051134109497, -0.015212233178317547, 0.014970293268561363, -0.01576497033238411, 0.011420552618801594, -0.005204034969210625, 0.008958369493484497, -0.0025904662907123566, 0.042785730212926865, -0.0368601456284523, 0.000037138815969228745, 0.0010670190677046776, 0.003940111957490444, -0.003715069033205509, -0.013807514682412148, -0.014620602130889893, 0.008926697075366974, -0.0069903964176774025, -0.03650025650858879, -0.0035952518228441477, -0.010424439795315266, 0.013577522709965706, 0.024650119245052338, -0.007301501464098692, 0.02407481148838997, -0.027247382327914238, 0.005697856657207012, 0.010425797663629055, 0.0015796683728694916, 0.015276985242962837, -0.0012892966624349356, 0.0034900917671620846, 0.01651427522301674, 0.02895243838429451, -0.004366838838905096, -0.002007190603762865, 0.004212102387100458, -0.00949444156140089, -0.006982308812439442, -0.08141851425170898, -0.0051108007319271564, 0.006554642226547003, -0.018109433352947235, 0.0062260814011096954, 0.008031702600419521, 0.014763307757675648, -0.00007235072553157806, -0.0194663368165493, -0.007694085594266653, -0.0031023607589304447, 0.006309978663921356, -0.009420782327651978, 0.02073626220226288, 0.03826954960823059, -0.011911636218428612, 0.017580077052116394, -0.01181500218808651, -0.004979792982339859, -0.03401445597410202, -0.005010267719626427, -0.028239764273166656, 0.008605855517089367, 0.001523459330201149, -0.03088655322790146, -0.00689306715503335, 0.014699391089379787, -0.01665237918496132, 0.016790039837360382, 0.004035618156194687, -0.027790427207946777, -0.016402171924710274, -0.005714506842195988, -0.017391638830304146, 0.05557984486222267, 0.015820534899830818, 0.012300615198910236, -0.0018740943633019924, -0.005344835110008717, 0.026635577902197838, -0.0012572729028761387, 0.005997338332235813, -0.015532886609435081, 0.012119623832404613, 0.000665145693346858, 0.02889145351946354, -0.013105884194374084, -0.0207732655107975, 0.01894408091902733, 0.0045012421905994415, 0.006502717733383179, 0.003685898147523403, 0.027670081704854965, 0.014093389734625816, -0.01170557551085949, -0.0002038269303739071, 0.006086787208914757, 0.021888073533773422, -0.006520373281091452, -0.020586293190717697, -0.024419745430350304, 0.002516387961804867, -0.0025507532991468906, 0.015581302344799042, -0.004526996985077858, -0.0009758513187989593, 0.012098601087927818, -0.0008472281042486429, -0.014833936467766762, 0.002427077852189541, 0.013713732361793518, -0.008731959387660027, -0.01932656206190586, 0.001824436243623495, -0.04496452212333679, -0.014946295879781246, -0.016282569617033005, -0.009186339564621449, 0.015081111341714859, -0.013618312776088715, -0.023285850882530212, 0.016178300604224205, 0.009511537849903107, 0.0020417168270796537, -0.009069140069186687, -0.02887236885726452, 0.008268357254564762, 0.04340023919939995, 0.017057541757822037, -0.015350846573710442, 0.03363354876637459, 0.002793879248201847, 0.004883359186351299, 0.011883683502674103, -0.01729312352836132, 0.008924794383347034, 0.0077326311729848385, 0.004977202042937279, -0.0005979761481285095, 0.008355390280485153, -0.026518603786826134, 0.00009561760816723108, 0.013592349365353584, -0.014392228797078133, -0.005811452399939299, 0.0068587008863687515, -0.023048035800457, -0.010414369404315948, -0.00802796334028244, 0.001903873635455966, -0.018380235880613327, -0.004878109320998192, -0.006695532705634832, 0.015330908820033073, 0.005556304939091206, -0.011484917253255844, -0.02140844240784645, -0.006338710896670818, 0.07249454408884048, 0.003931036219000816, 0.0052596270106732845, -0.027483195066452026, -0.0035323721822351217, -0.012844044715166092, -0.0049297139048576355, 0.017452917993068695, -0.00598306767642498, 0.005277079064399004, 0.011599685996770859, 0.004316692240536213, 0.01431146077811718, 0.01429805438965559, -0.019496196880936623, 0.0007043522782623768, 0.004142488818615675, -0.002272922545671463, 0.0053523532114923, 0.030569156631827354, 0.016931377351284027, -0.04670991003513336, -0.03815928474068642, 0.03369532898068428, 0.005416187457740307, 0.004399004392325878, 0.014204846695065498, -0.016191449016332626, -0.03557483106851578, 0.011047247797250748, 0.016776515170931816, -0.021076790988445282, -0.009814226999878883, 0.026953481137752533, 0.02350638434290886, 0.001616019755601883, 0.00860079750418663, 0.0013145823031663895, 0.005313635803759098, -0.004599648527801037, 0.013496498577296734, -0.01972830295562744, -0.023464396595954895, 0.011694785207509995, -0.013139903545379639, -0.0054101357236504555, -0.007251066155731678, -0.009069063700735569, -0.0014055606443434954, 0.020240984857082367, -0.010070675052702427, -0.007608877960592508, 0.007308376021683216, 0.010732020251452923, -0.0030424222350120544, -0.027714336290955544, -0.0018793008057400584, -0.020561914891004562, -0.008093588054180145, 0.005444212816655636, -0.00743546336889267, 0.026571054011583328, 0.015116823837161064, -0.02321627177298069, 0.019529085606336594, -0.03447451442480087, -0.01784076914191246, -0.008163876831531525, -0.019188150763511658, 0.030915111303329468, 0.030248330906033516, 0.019046397879719734, -0.009990371763706207, -0.010568743571639061, -0.010088901966810226, 0.016769777983427048, -0.01461740117520094, -0.007099517155438662, 0.025572728365659714, -0.016022194176912308, -0.02430155873298645, 0.012046786025166512, -0.004680105485022068, 0.001943760784342885, -0.012140960432589054, -0.023014789447188377, -0.01408318616449833, -0.07467428594827652, -0.0027579241432249546, -0.0038065239787101746, -0.004762914963066578, -0.0023827380500733852, 0.00888176541775465, -0.017172209918498993, -0.007740619592368603, -0.00748978927731514, -0.0037342379800975323, 0.03689198195934296, 0.00753062404692173, 0.010826398618519306, -0.0027830186299979687, 0.011161376722157001, 0.016824573278427124, -0.012433861382305622, -0.003911694046109915, -0.008457615971565247, -0.012829158455133438, -0.00893186405301094, -0.01590574160218239, -0.033403635025024414, -0.012442203238606453, -0.009644672274589539, -0.08154350519180298, -0.020623451098799706, 0.012831082567572594, 0.0021873973309993744, -0.013848685659468174, -0.001824486069381237, -0.02357582002878189, -0.001313097309321165, -0.00402956735342741, -0.014645876362919807, -0.0059103346429765224, 0.004463952034711838, -0.011113355867564678, -0.0033642672933638096, 0.0013563642278313637, -0.008245609700679779, 0.012386888265609741, -0.054812606424093246, 0.016161702573299408, 0.01935751363635063, -0.01125180721282959, 0.0019670703914016485, -0.011350415647029877, -0.0027564214542508125, -0.01095812302082777, -0.023726271465420723, -0.011746631935238838, 0.01698189228773117, 0.000988485524430871, -0.0039839968085289, -0.005958074703812599, -0.01848727837204933, -0.0149317542091012, -0.03735218197107315, -0.02136845700442791, -0.012100214138627052, 0.010099940933287144, -0.005935250781476498, 0.012767218984663486, -0.015855401754379272, -0.010167034342885017, -0.00025698787067085505, -0.01745799370110035, 0.025486696511507034, -0.02053469605743885, -0.0006711271125823259, 0.007388617377728224, -0.013984420336782932, -0.0026013313326984644, -0.01735015958547592, 0.00813258346170187, -0.006987954489886761, -0.0019184860866516829, 0.021450592204928398, 0.01918948069214821, 0.0024419014807790518, 0.0026096547953784466, 0.003716534934937954, 0.019748203456401825, 0.007335878908634186, -0.018368830904364586, 0.010858157649636269, 0.012652380391955376, 0.07173597812652588, -0.026053188368678093, 0.008730252273380756, -0.014330938458442688, 0.011481089517474174, 0.006088913418352604, -0.014084408059716225, -0.0011020260863006115, -0.015993405133485794, -0.020364178344607353, -0.012931102886795998, -0.00932753924280405, 0.0027885129675269127, 0.010722088627517223, 0.023039624094963074, 0.0430348664522171, -0.009347211569547653, 0.006011054385453463, -0.007411612197756767, 0.021161165088415146, 0.01039968803524971, 0.05288490653038025, 0.021296828985214233, -0.006074563600122929, -0.008720070123672485, -0.011885251849889755, -0.011446026153862476, 0.024211235344409943, -0.026597047224640846, -0.012393549084663391, 0.007244334556162357, -0.01624751091003418, 0.000023442902602255344, 0.005744734779000282, 0.018841885030269623, 0.012991780415177345, -0.004112191032618284, 0.006659855600446463, -0.025644734501838684, -0.015878600999712944, 0.024780455976724625, -0.00721739511936903, -0.008157354779541492, -0.01323559321463108, 0.0387958362698555, -0.013144132681190968, 0.017360270023345947, -0.0035538908559828997, -0.0038152749184519053, -0.00292326882481575, 0.03576584905385971, -0.006938735954463482, 0.00860525481402874, -0.020209891721606255, 0.03001624159514904, 0.002448451705276966, 0.003723544767126441, 0.011452451348304749, -0.0010711224749684334, -0.03216615319252014, 0.009185051545500755, -0.025472013279795647, 0.014713561162352562, -0.011592631228268147, 0.01426936686038971, -0.010895864106714725, -0.018321268260478973, -0.0291199441999197, 0.024461425840854645, 0.0161593034863472, 0.008540010079741478, 0.004232759587466717, 0.008742863312363625, -0.0017168347258120775, 0.04175762087106705, 0.005690501071512699, 0.008013454265892506, -0.04063507542014122, 0.042815618216991425, 0.008550852537155151, -0.012407970614731312, -0.010860325768589973, 0.00751336058601737, 0.0023011325392872095, -0.002890787087380886, 0.013043902814388275, -0.020923396572470665, 0.019356943666934967, 0.0028152954764664173, 0.01373613253235817, -0.002170522464439273, -0.010168208740651608, 0.003737460356205702, -0.006939504761248827, 0.010078397579491138, 0.03365818411111832, 0.010536514222621918, 0.008420784026384354, -0.002237579319626093, -0.0012105260975658894, -0.0028067438397556543, -0.026559337973594666, -0.030783239752054214, 0.005718493368476629, -0.00711053516715765, 0.003172375028952956, 0.034469544887542725, -0.004015554673969746, -0.004490433726459742, -0.0008886577561497688, 0.00826776772737503, 0.006600565742701292, -0.007183843292295933, 0.013631841167807579, 0.016438456252217293, 0.02966482751071453, -0.029286332428455353, -0.0033781458623707294, -0.026765789836645126, -0.010533507913351059, 0.011740211397409439, -0.0050629861652851105, -0.007532707415521145, 0.04746876657009125, 0.009319383651018143, -0.008381325751543045, -0.010541802272200584, 0.008137457072734833, -0.0012562214396893978, -0.011264464817941189, 0.022601667791604996, -0.03323381394147873, 0.008566764183342457, 0.004904384724795818, 0.032203931361436844, 0.00525070633739233, 0.03396410495042801, 0.02103591151535511, -0.0030636778101325035, 0.008220329880714417, 0.0170905701816082, -0.007372440304607153, -0.0023419689387083054, -0.014798667281866074, 0.006861986592411995, -0.01567954197525978, 0.010708455927670002, 0.03708362579345703, 0.0013787783682346344, 0.00847697351127863, 0.011731182225048542, 0.008205566555261612, -0.04607634246349335, -0.007839418016374111, -0.04267197847366333, 0.015553191304206848, 0.009361742064356804, -0.035587772727012634, -0.001833123154938221, 0.006739264354109764, 0.021944986656308174, -0.004384287633001804, -0.01244203932583332, 0.009778955951333046, 0.026490503922104836, 0.0005316128954291344, 0.03308815509080887, 0.008286701515316963, -0.016259506344795227, -0.001551958965137601, -0.0020571155473589897, 0.004650447051972151, -0.0023277574218809605, 0.016021504998207092, 0.0008913623169064522, -0.01040074322372675, -0.005529229063540697, -0.01948135532438755, 0.008827583864331245, 0.009716568514704704, -0.010283679701387882, 0.008606364950537682, 0.013215893879532814, -0.010131007060408592, 0.011458110995590687, 0.006458534859120846, 0.0022806753404438496, 0.01212325505912304, 0.006225585471838713, 0.0294032022356987, 0.01164616271853447, -0.007494856137782335, -0.02113284543156624, 0.010168966837227345, -0.006710562855005264, -0.008614862337708473, -0.0216916985809803, 0.004430301487445831, 0.022912688553333282, 0.008108380250632763, 0.01640372723340988, 0.005551355890929699 ]
[ 0.11506673693656921, -0.13487841188907623, 0.29525935649871826, 0.0979316309094429, -0.09694763273000717, -0.08490900695323944, 0.10401143878698349, 0.02946585603058338, -0.47226911783218384, -0.18407042324543, -0.09589113295078278, -0.061080507934093475, -0.40771469473838806, 0.045564915984869, -0.04720763862133026, 0.4079660177230835, 0.14489391446113586, 0.11155690252780914, -0.30946579575538635, -1.0243072509765625, 0.07325269281864166, -0.45923522114753723, 0.4184895157814026, 0.038865748792886734, 0.4398382306098938, 0.20804043114185333, 0.1615869700908661, 0.07805278152227402, 0.44717860221862793, -0.21049970388412476, -0.731012761592865, 0.1830279678106308, 0.2920086979866028, 0.14518053829669952, -0.1811523139476776, -0.09006433933973312, -0.40281715989112854, 0.17165173590183258, 0.24163609743118286, 0.08824963122606277, -0.33092987537384033, -0.35495078563690186, -0.07575336843729019, 0.30667248368263245, -0.2828296422958374, -0.17558498680591583, -1.2752997875213623, 1.0199872255325317, -0.34227699041366577, -0.07444751262664795, -0.017420867457985878, 0.723211407661438, 0.4672631621360779, -0.054381538182497025, 0.16812105476856232, 0.13793744146823883, -0.4830402135848999, 0.12362313270568848, 0.3490106463432312, -0.7064763903617859, -0.2722000181674957, -0.11697530001401901, -0.10475287586450577, 0.02038784883916378, -0.06654055416584015, 0.5023398995399475, 0.10876430571079254, -0.450473815202713, -0.2397523820400238, -0.48643559217453003, 0.05606657639145851, -0.19801278412342072, -0.41835951805114746, 0.15900345146656036, 0.24084524810314178, 0.3376553952693939, -0.23878277838230133, -0.06135764718055725, 0.003194805234670639, 0.08133159577846527, -0.2337481528520584, 0.22388887405395508, 0.4451408386230469, 0.053515467792749405, 0.8011283278465271, 0.11225128173828125, -0.43761980533599854, 0.7311446666717529, -0.06829807907342911, -0.09881388396024704, -0.07919517904520035, -0.041928473860025406, 0.10278227925300598, 0.6314229965209961, -0.2736626863479614, 0.4214184284210205, -0.002520579844713211, -0.19207893311977386, 0.14849327504634857, 0.19836509227752686, -0.19646413624286652, -0.007083972450345755, 0.3444785475730896, -0.23055046796798706, -0.13788002729415894, -0.05744427442550659, -0.21850992739200592, -0.447691947221756, -0.9700027108192444, -0.035639937967061996, -0.4189358949661255, -0.045424189418554306, -0.4454563856124878, -0.21254073083400726, 0.6474119424819946, -0.1229017898440361, 0.18769271671772003, -0.8445259928703308, 0.24187111854553223, 0.3383243680000305, -0.3107932507991791, 1.2508596181869507, -0.07643905282020569, 0.5873847603797913, -0.055944789201021194, 0.23408633470535278, 0.13286177814006805, -0.1552032083272934, -0.10845295339822769, 0.6870407462120056, 0.3931533098220825, 0.6149777173995972, 0.0036195681896060705, 0.33656004071235657, -0.026343056932091713, -0.09570294618606567, 0.570927619934082, 0.20235702395439148, 0.5738313794136047, 0.1706734001636505, -0.7501566410064697, -0.19810129702091217, 0.003279848489910364, -0.19014424085617065, -0.14314576983451843, -0.5574615001678467, -0.34775176644325256, -0.4517381191253662, 0.026373373344540596, 0.09917940944433212, 0.03960482403635979, -0.2734786570072174, -0.5480870008468628, -0.28377997875213623, -0.18900762498378754, 0.08240532875061035, 0.23129913210868835, -0.25361207127571106, -0.1972143054008484, 0.5732054710388184, 0.16608324646949768, 0.08630960434675217, -0.3900424540042877, 0.07108131051063538, 0.031499069184064865, 0.2573280930519104, 0.48237770795822144, 0.16497407853603363, 0.03212697058916092, 0.01625848188996315, -0.38299843668937683, -0.1004253700375557, -0.10745402425527573, -0.5791701674461365, -0.4130627512931824, 0.024021528661251068, 0.0060238963924348354, -0.2662719190120697, 0.26292669773101807, -0.02174249291419983, -0.6924638152122498, 0.02835698612034321, -0.08275565505027771, -0.579971969127655, 0.1355709433555603, 0.31300991773605347, 0.7221145033836365, 0.028167294338345528, -0.003134635742753744, -0.4824194312095642, -0.31837940216064453, -0.13961941003799438, 0.7256719470024109, -0.8184449076652527, 1.2065272331237793, -0.188584104180336, -0.06547848880290985, 1.1508327722549438, 0.7001193165779114, 0.06276432424783707, -0.1918479949235916, 0.1253458559513092, 0.6477323174476624, -0.7194653153419495, -0.07361257821321487, -0.08420661091804504, -0.24498702585697174, -0.03506605699658394, 0.08752073347568512, -0.08684398978948593, 0.14727163314819336, -0.3116832375526428, -0.10289248079061508, -0.18885132670402527, 0.3420945107936859, -0.1411706507205963, -0.1554354876279831, 0.07656747847795486, -0.11584895104169846, -0.04976866394281387, 0.16243645548820496, -0.5047979950904846, 0.44519004225730896, 0.7685202360153198, -0.2847594618797302, 0.9206550717353821, 0.4520571231842041, 0.21825116872787476, 0.5916001200675964, -0.22180739045143127, 0.356581449508667, -0.4267730712890625, -0.05727803334593773, -0.3486637771129608, 0.004085268825292587, 0.04340929538011551, 0.14894919097423553, -0.13805317878723145, -0.37843286991119385, 0.061821047216653824, -0.24148283898830414, 0.8066724538803101, -0.7420239448547363, -0.3872525095939636, -0.3219543993473053, -0.4115463197231293, -0.2555679678916931, 0.23521263897418976, -0.796023964881897, 0.012296860106289387, 0.01554124429821968, 0.2443154752254486, -0.15842857956886292, -0.44135528802871704, -0.49633723497390747, 0.0728987380862236, -0.3191397488117218, -0.6140168309211731, 0.23672740161418915, -0.15164852142333984, 0.14180906116962433, -0.4445599317550659, 0.1176818236708641, 0.33435872197151184, -0.046104151755571365, -0.5256767868995667, -0.32918959856033325, -0.07691516727209091, 1.1686197519302368, 0.6721709370613098, 1.0070886611938477, -0.3726769685745239, -0.6003021001815796, -0.16898506879806519, 0.018464498221874237, -0.8934681415557861, 0.1178208589553833, 0.5837522745132446, -0.24923698604106903, -0.39096882939338684, -0.3649187982082367, -0.14088702201843262, 0.7972697615623474, 0.07574063539505005, -0.21781696379184723, -0.10988380014896393, -0.09885182231664658, -0.263846755027771, -0.170695498585701, -0.4562469720840454, -0.08729980885982513, 0.6055648922920227, -0.2696845829486847, -0.07990313321352005, 0.38644567131996155, 0.5863572359085083, 0.3128008246421814, 0.486924409866333, 0.523962140083313, -0.13355492055416107, -0.15206381678581238, 0.08773170411586761, -0.6759300231933594, -0.15069618821144104, 0.026865029707551003, 0.11536882817745209, -0.2506662905216217, -0.17324119806289673, -5.977475166320801, 0.22351738810539246, 0.06928706169128418, -0.6164424419403076, 0.34364959597587585, -0.00908716395497322, 1.0376176834106445, 0.07287366688251495, 0.373675137758255, -0.08511066436767578, 0.2260167896747589, -0.2571750581264496, -0.29942822456359863, -0.012477328069508076, -0.10495353490114212, 0.31004929542541504, 0.2448112964630127, 0.03728507086634636, 1.0579473972320557, 0.16404516994953156, 0.04961761459708214, -0.2112453579902649, 0.23348236083984375, 0.2015417069196701, 0.14977246522903442, 0.28733712434768677, -0.9855995774269104, -0.2829494774341583, -0.013814781792461872, -0.38130438327789307, 0.19708168506622314, -0.7535684704780579, -0.1404992789030075, -0.22028711438179016, 0.17619967460632324, -0.2821216583251953, 0.042081318795681, -0.23055309057235718, 0.26835423707962036, -0.1971650868654251, 0.36252298951148987, 0.29223746061325073, -0.06446214765310287, -0.08587510883808136, 0.1741255670785904, -0.07609297335147858, -0.4106917977333069, -0.17153681814670563, -0.36035463213920593, 0.6693724393844604, -0.10568488389253616, -0.1082644909620285, 0.02329055778682232, 0.07480879873037338, 0.36414387822151184, 0.03950575366616249, -0.39870187640190125, 0.008757131174206734, -0.48622578382492065, 0.1489754319190979, -0.2334369421005249, -0.10211557894945145, -0.021213367581367493, -0.6154030561447144, -0.07443436980247498, 0.48420265316963196, -0.5010977983474731, -0.10320780426263809, 0.9268641471862793, -0.4539738595485687, 0.055786628276109695, -0.211076557636261, 0.16971880197525024, -0.6670364737510681, 0.5202261805534363, -0.2346968799829483, -0.24278175830841064, 0.1540592759847641, 0.022295808419585228, -0.2235460877418518, -0.36094704270362854, -0.13720330595970154, 0.35119572281837463, -0.4343450963497162, 0.18514138460159302, -0.19485031068325043, -0.679538905620575, -0.1959434300661087, -0.24468035995960236, 0.44810932874679565, 0.38414785265922546, -0.41895192861557007, 0.012041979469358921, 0.5192558765411377, 0.558100163936615, 0.2847922444343567, 0.5420951843261719, 0.42787858843803406, 0.4398076832294464, 0.06700285524129868, 0.3637521266937256, -0.17409637570381165, -0.28788623213768005, -0.7698709964752197, 0.08101879805326462, 0.24365529417991638, -0.47047385573387146, 0.3907511830329895, 0.7471998929977417, -0.4561050534248352, 0.017507219687104225, -0.16450311243534088, -0.3964272737503052, -0.07980258762836456, 0.537187397480011, -0.1014246940612793, -0.11809945851564407, 0.08993399143218994, 0.448478639125824, -0.38001447916030884, -0.03585059195756912, -0.07704188674688339, -0.7630701065063477, 0.1050773337483406, 0.06352782994508743, -0.3058262765407562, 0.18259750306606293, 0.7258532643318176, -0.18983913958072662, -0.4372924268245697, 0.22015072405338287, 0.11459064483642578, -0.14094623923301697, -0.27882352471351624, -0.016978805884718895, -0.09872949123382568, -0.32759103178977966, 0.14804843068122864, 0.6998610496520996, 0.10938168317079544, 0.08872632682323456, 0.13351970911026, 0.10506170988082886, 0.27449846267700195, 0.7056010365486145, 0.04560495540499687, 0.0432484932243824, 0.2302742898464203, -0.26062512397766113, -0.6749559044837952, 0.3229599595069885, -0.09001614898443222, 0.4371377229690552, -0.06755155324935913, -0.21989873051643372, 0.037208184599876404, 0.4096578061580658, -0.027855943888425827, 0.3898083567619324, -0.4054998755455017, 0.2788561284542084, 0.06365334987640381, -0.8388862609863281, 0.5966013073921204, -0.4213680922985077, -0.4397955536842346, -0.1523314267396927, -0.38302910327911377, 0.1853465884923935, 0.05340895801782608, -0.2713693082332611, -0.46479615569114685, 0.14937376976013184, 0.05280487611889839, 0.03518781065940857, -0.3310666084289551, -0.257158488035202, 0.12996651232242584, 0.04614906385540962, 0.09955517202615738, -0.3430555760860443, -0.28513142466545105, -0.22863641381263733, 0.2684023380279541, 0.4234849512577057, 0.21756626665592194, 0.23222041130065918, 0.100863978266716, 0.15123620629310608, -0.25363054871559143, 0.043434858322143555, -0.010065351612865925, 0.21768175065517426, -0.034166645258665085, 0.07222195714712143, 0.12698352336883545, 0.36182209849357605, 0.3417903482913971, 0.02759300172328949, -0.7374067306518555, -0.04596512019634247, -0.013391971588134766, -0.5342723727226257, 0.363369882106781, 0.25977012515068054, 0.180485337972641, -0.47094860672950745, 0.03652099147439003, 0.07590829581022263, -0.6500381231307983, 0.023215852677822113, -0.35900935530662537, 0.23354749381542206, 0.4695485234260559, -0.014004657976329327, -0.016728008165955544, 0.306454062461853, -0.13993525505065918, -0.11094851046800613, 0.3062794804573059, 0.4566791355609894, 0.12697084248065948, 0.07692407071590424, 0.09670017659664154, -0.23026293516159058, 0.16191072762012482, 0.6148627996444702, -0.8916581869125366, 0.24657012522220612, -0.07238995283842087, 0.039328258484601974, -0.0605580098927021, 0.08720333129167557, 0.14922326803207397, -0.6274253726005554, -0.26022741198539734, -0.27453169226646423, 0.37563854455947876, 0.24989144504070282, 0.4503958225250244, 0.28967732191085815, 0.47198399901390076, -0.30828818678855896, 0.1008169874548912, 0.08620326220989227, 0.571847677230835, 0.25834500789642334, -0.5424956679344177, -0.15568982064723969, 0.16780026257038116, 0.8231101632118225, -0.19508761167526245, 0.09687210619449615, 0.7957680821418762, 0.8368634581565857, 0.052496787160634995, -0.6871718168258667, -0.08817934989929199, -0.22909314930438995, 0.2100994735956192, -0.2589598000049591, -0.013595341704785824, -0.16409897804260254, -0.03895711526274681, -0.09135802090167999, 0.10230657458305359, -0.4519427418708801, -0.4934734106063843, 0.4249091148376465, -0.12537898123264313, -0.2417401820421219, -0.09953062236309052, 0.6540001034736633, 0.6022183299064636, 0.025391029193997383, 0.21831601858139038, -0.2273099571466446, 0.332492470741272, -0.031381089240312576, 0.2724071443080902, -0.45204073190689087, -0.6743903160095215, 0.8302540183067322, -0.782258152961731, 0.3983219265937805, -0.7105551958084106, 0.10402520000934601, -0.27590611577033997, 0.24238310754299164, -0.34344568848609924, -0.5381073355674744, 0.058071721345186234, -0.3350299000740051, -0.9284175038337708, -0.3976219892501831, 0.1431398242712021, 0.4051555395126343, 0.20623566210269928, 0.23229293525218964, 0.1313079446554184, -0.5962311625480652, 0.3382400572299957, 0.4610021114349365, -0.44639360904693604, -0.15885071456432343, -0.1157744750380516, -0.12554430961608887, 0.11940338462591171, -0.7091822028160095, -0.38089969754219055, -0.20867231488227844, -0.12044411897659302, 0.20607857406139374, -0.3446509838104248, -0.5254446268081665, -0.04582264646887779, 0.07097402960062027, -0.19846126437187195, 0.3580300807952881, 0.5299093127250671, 0.3735981285572052, 0.9324008226394653, 0.47647324204444885, -0.03608965873718262, 0.28369325399398804, 0.15988653898239136, 0.45083582401275635, 0.16323520243167877, -0.03622971102595329, 0.05666608735918999, 0.3731299936771393, -0.03828702121973038, 0.020270470529794693, 0.624193549156189, 0.38458719849586487, 0.4164741337299347, 0.19181691110134125, -0.672949492931366, -0.09090065956115723, -0.023426931351423264, 0.7596437335014343, 0.6198310852050781, -0.34593379497528076, -0.5588518977165222, 0.21892669796943665, -0.27264952659606934, 0.3319823145866394, 0.1518155038356781, -0.12268832325935364, 0.746717631816864, 0.023868605494499207, -0.40093687176704407, -0.5723543167114258, -0.06978701800107956, -0.5827028155326843, 0.20563754439353943, 0.4228866696357727, -0.032716985791921616, -0.6815486550331116, 0.05910395085811615, -0.4878583252429962, 0.34738653898239136, 0.22071877121925354, 1.0015969276428223, -0.4935572147369385, 0.025439146906137466, 0.33023273944854736, 0.5302694439888, 0.36601781845092773, -0.25136423110961914, -0.14996792376041412, -0.16927474737167358, -0.12702882289886475, 0.30415111780166626, 0.22146332263946533, -0.4889177083969116, -0.0509953647851944, -0.1206471398472786, -0.19163775444030762, 0.42721080780029297, -0.018277930095791817, -0.01281785685569048, 0.08245211094617844, -0.35997313261032104, 0.12056761234998703, -0.33135339617729187, -0.2949502766132355, -0.17568951845169067, -0.15225933492183685, 0.37659910321235657, 0.036734357476234436, -0.3831294775009155, 0.4298170506954193, 0.2454177588224411, -0.03029225766658783, 0.12022511661052704, -0.28960078954696655, 0.33071357011795044, 0.2336542159318924, 0.6569727063179016, 0.049310363829135895, 0.3436088263988495, 0.07803315669298172, 0.24462677538394928, -0.24944838881492615, 0.3644110858440399, -0.5049085021018982, -0.36330080032348633, -0.6108644604682922, -0.16344422101974487, 0.9495182037353516, 0.7080531716346741, -0.29906848073005676, -0.30289226770401, 0.3279031217098236, -0.0755540132522583, 0.5115383267402649, -0.15553347766399384, -0.026770206168293953, -0.10212767869234085, -0.12695758044719696, -0.551215410232544, 0.6671494841575623, 0.2281913012266159, -0.10058250278234482, -0.1541406512260437, 0.7528781294822693, 0.15676374733448029, -0.3859088122844696, 0.12135849893093109, -0.08848506957292557, -0.14829014241695404, -0.45377233624458313, 0.31484073400497437, -0.37570059299468994, 0.05305017903447151, -0.3963654637336731, 0.502859890460968, 0.26778289675712585, -0.765601634979248, 0.2656645178794861, 0.01709904707968235, 0.14605319499969482, -0.2540972828865051, 0.1623305231332779, 0.07843071222305298, 0.07272461801767349, -0.8265001773834229, -0.8123347759246826, 0.1975289285182953, -0.1194484755396843, -0.7344136834144592, -0.3233549892902374, 0.48269057273864746, -0.24127079546451569, -0.21187429130077362, 0.35361000895500183, -0.31213676929473877, -0.2758735716342926, -0.4571397006511688 ]
BACKGROUND Patients with familial amyloid polyneuropathy, a rare hereditary form of amyloidosis, have progressive autonomic neuropathy. The disease usually does not induce heart failure but is associated with sudden death, conduction disturbances, and an increased risk of complications during anesthesia. Although cardiac sympathetic denervation has been clearly demonstrated, the postsynaptic status of the cardiac autonomic nervous system remains unelucidated. METHODS AND RESULTS Twenty-one patients were studied (age, 39+/-11 years; normal coronary arteries; left ventricular ejection fraction 68+/-9%). To evaluate the density and affinity constants of myocardial muscarinic receptors, PET with (11)C-MQNB (methylquinuclidinyl benzilate), a specific hydrophilic antagonist, was used. Cardiac beta-receptor functional efficiency was studied by the heart rate (HR) response to intravenous infusion of isoproterenol (5 minutes after 2 mg of atropine, 5, 10, and 15 ng/kg per minute during 5 minutes per step). The mean muscarinic receptor density was higher in patients than in control subjects (B'(max), 35.5+/-8.9 versus 26.1+/-6.7 pmol/mL, P=0.003), without change in receptor affinity. The increase in HR after injection of atropine as well as of MQNB was lower in patients compared with control subjects despite a similar basal HR (DeltaHR after atropine, 11+/-21% versus 62+/-17%; P<0.001), consistent with parasympathetic denervation. Incremental infusion of isoproterenol induced a similar increase in HR in patients and control subjects. CONCLUSIONS Cardiac autonomic denervation in familial amyloid polyneuropathy results in an upregulation of myocardial muscarinic receptors but without change in cardiac beta-receptor responsiveness to catecholamines.
[ -0.036392390727996826, 0.013793637976050377, -0.005964064039289951, 0.02468404546380043, -0.028447963297367096, -0.02965618669986725, 0.009774072095751762, 0.029012715443968773, -0.012911004945635796, 0.034113191068172455, -0.013458450324833393, 0.018259726464748383, 0.02175072953104973, 0.046226225793361664, 0.037615373730659485, 0.021702729165554047, -0.008069353178143501, 0.009976389817893505, 0.005499923601746559, -0.025833364576101303, 0.027461927384138107, -0.0026504122652113438, 0.010339304804801941, 0.01753576099872589, -0.013921507634222507, -0.00147162564098835, 0.023006923496723175, 0.0008163796737790108, 0.019825655966997147, 0.013043900951743126, -0.010979853570461273, 0.017602939158678055, -0.03283245116472244, -0.012197263538837433, 0.016598913818597794, 0.005181551445275545, 0.007303906138986349, 0.017600521445274353, 0.029176924377679825, -0.003952430095523596, 0.04247942566871643, -0.007779038976877928, 0.010713528841733932, -0.0012099635787308216, -0.00864565372467041, -0.016161708161234856, -0.0012657034676522017, 0.008089697919785976, -0.0049268510192632675, 0.009213070385158062, -0.007672745734453201, -0.02951502427458763, -0.01906547136604786, -0.02506795898079872, -0.006758269853889942, -0.013899932615458965, 0.020188886672258377, -0.02141646295785904, 0.0011416450142860413, 0.014399145729839802, 0.005787473171949387, -0.025249755010008812, 0.006203693337738514, 0.005595589056611061, -0.03070966713130474, -0.06661565601825714, 0.002546901348978281, -0.0009591355919837952, -0.008936744183301926, -0.014889487996697426, -0.0012250144500285387, 0.005105343647301197, 0.007765839342027903, 0.0028493988793343306, -0.005076948553323746, 0.0023400159552693367, -0.014784185215830803, 0.021081944927573204, 0.012807355262339115, -0.0010166929569095373, -0.012129992246627808, -0.01756034605205059, 0.0073905931785702705, 0.01682734116911888, -0.020909655839204788, 0.033345505595207214, -0.02605104260146618, 0.01197719294577837, 0.014572248794138432, -0.026661701500415802, 0.024621836841106415, 0.003757934086024761, -0.004247121047228575, -0.0030943951569497585, 0.027058692649006844, -0.015422884374856949, -0.013786371797323227, 0.03651996701955795, -0.003958878107368946, -0.04236004501581192, -0.007482248358428478, 0.021284565329551697, 0.017182303592562675, -0.006418238393962383, -0.00044291140511631966, 0.005666336975991726, 0.026546446606516838, 0.0009497608989477158, 0.07142612338066101, 0.016648821532726288, -0.0009451443329453468, 0.012884375639259815, 0.004496700130403042, 0.005971627309918404, 0.0025350255891680717, -0.0033871587365865707, 0.014887886121869087, -0.017019886523485184, -0.000607710680924356, 0.009777039289474487, 0.008867953903973103, -0.009145516902208328, -0.0029892807360738516, 0.007798465900123119, -0.0006319342064671218, -0.019387777894735336, 0.0006072849500924349, -0.024004876613616943, 0.005255123134702444, -0.009427706710994244, -0.00784980971366167, -0.004094029776751995, -0.0008581993170082569, -0.004086194559931755, -0.0005864767590537667, -0.0016760011203587055, -0.023938748985528946, -0.004619397222995758, -0.0007538439240306616, -0.02707340568304062, 0.007983524352312088, 0.011695549823343754, 0.001383615075610578, 0.00963000487536192, -0.014533326029777527, -0.004604452755302191, 0.029792189598083496, 0.01046735979616642, 0.012132651172578335, -0.012892812490463257, 0.010708908550441265, 0.005733288824558258, 0.016254663467407227, -0.020570700988173485, 0.010789033025503159, -0.005452113226056099, -0.017253704369068146, -0.013322915881872177, 0.0023846696130931377, 0.011034916155040264, -0.011264354921877384, 0.009544121101498604, 0.012654822319746017, 0.010420341044664383, 0.00048084557056427, -0.003992230165749788, 0.02414991706609726, -0.01087989378720522, -0.027972150593996048, 0.0062668235041201115, 0.0011229647789150476, -0.0073578739538788795, 0.008100882172584534, 0.011014364659786224, 0.009063509292900562, -0.009265512228012085, 0.04143460467457771, 0.005637044087052345, 0.004642029292881489, 0.06606131792068481, 0.026507344096899033, -0.007030121982097626, 0.002596704289317131, -0.0011096179950982332, 0.017616581171751022, -0.01102597638964653, -0.02441377192735672, -0.010468848049640656, -0.003411397337913513, 0.010484126396477222, 0.003140629269182682, 0.004908273462206125, -0.017226016148924828, -0.002219848334789276, 0.03566635772585869, 0.004444716963917017, -0.004492809064686298, -0.009799381718039513, 0.01278015598654747, 0.02675233781337738, 0.046574681997299194, -0.004821627400815487, 0.029862843453884125, -0.026144947856664658, 0.019550085067749023, 0.005995107814669609, 0.016273071989417076, -0.002949077170342207, 0.03374408930540085, 0.017522180452942848, -0.013630769215524197, 0.04305487126111984, -0.022671522572636604, -0.005968350917100906, -0.010885875672101974, -0.018256105482578278, -0.0028215679340064526, 0.03213953971862793, -0.018501661717891693, -0.014978118240833282, -0.0006256832275539637, 0.025860551744699478, 0.0048727719113230705, 0.0030215629376471043, 0.010514997877180576, 0.0007665921002626419, 0.010301412083208561, 0.007338457275182009, 0.004928979557007551, 0.011018850840628147, -0.007478705607354641, -0.005554065573960543, -0.008727897889912128, -0.01601288467645645, 0.036450210958719254, 0.024143025279045105, 0.015334386378526688, -0.0002226545475423336, 0.014961889944970608, -0.018941402435302734, -0.007150620222091675, 0.022489627823233604, 0.007484260015189648, -0.02516808919608593, 0.026255004107952118, -0.011505480855703354, 0.007912062108516693, -0.014565156772732735, 0.01747518591582775, -0.02442789077758789, 0.011097844690084457, -0.01086315605789423, 0.012743089348077774, 0.01659994199872017, -0.006562419235706329, -0.02637406624853611, 0.04141845181584358, -0.018631376326084137, 0.026671599596738815, -0.0020885178819298744, 0.013147320598363876, 0.008991649374365807, 0.003808113746345043, -0.004082322586327791, -0.057910241186618805, -0.010086504742503166, 0.009461997076869011, -0.004359841346740723, 0.002218577079474926, 0.0068481541238725185, 0.005275048781186342, -0.013984614983201027, -0.01354056317359209, -0.08111242949962616, -0.010379389859735966, -0.02130984514951706, 0.01890208199620247, 0.002305464819073677, 0.024687713012099266, 0.024569939821958542, 0.014939342625439167, -0.008313074707984924, -0.02320389449596405, -0.0014335177838802338, -0.00819417368620634, -0.007162242196500301, 0.010937655344605446, -0.00966077484190464, -0.0035156174562871456, 0.009657434187829494, 0.02369735762476921, -0.02944982424378395, -0.015238529071211815, 0.014669708907604218, -0.012276995927095413, 0.011937637813389301, 0.005705052986741066, 0.0015133158303797245, 0.015287348069250584, 0.0016778968274593353, -0.006913094315677881, 0.011067274957895279, 0.016323991119861603, 0.013155294582247734, 0.007989990524947643, 0.009124103002250195, -0.007019956596195698, 0.0018983418121933937, 0.009095532819628716, -0.022372456267476082, 0.006500180810689926, -0.017597734928131104, -0.0007507875561714172, -0.02061273157596588, 0.014123513363301754, 0.004710983484983444, -0.022080697119235992, 0.012331457808613777, 0.0025861936155706644, 0.0241764634847641, -0.0170487929135561, 0.017553620040416718, -0.009051002562046051, 0.011319460347294807, 0.0036143455654382706, -0.0008622570894658566, 0.012971693649888039, -0.010804986581206322, 0.0012781063560396433, 0.02096210978925228, 0.005418068263679743, -0.0048932768404483795, -0.013564784079790115, -0.0079928208142519, 0.008465541526675224, -0.006457028444856405, -0.003721448592841625, 0.00719811674207449, -0.0005800840444862843, 0.025889797136187553, -0.001167232170701027, -0.014212075620889664, 0.006737503223121166, -0.025069765746593475, 0.004789299331605434, 0.012319402769207954, -0.013105137273669243, -0.021704429760575294, -0.0007696224492974579, -0.012452616356313229, -0.012093454599380493, -0.005553192459046841, 0.009718062356114388, -0.023269742727279663, -0.00021776696667075157, 0.010527636855840683, 0.018979305401444435, -0.015384006313979626, -0.004263488110154867, 0.008128613233566284, 0.020753934979438782, 0.019792970269918442, -0.0116200540214777, -0.003015046939253807, 0.022831499576568604, 0.0075219543650746346, 0.007770385593175888, 0.010511915199458599, -0.0016114558093249798, 0.0026633054949343204, -0.007205530069768429, 0.015441481955349445, 0.007893173955380917, -0.019914939999580383, -0.006851662881672382, 0.0038846584502607584, -0.00518482830375433, -0.004962828941643238, 0.010257964953780174, 0.015056053176522255, 0.01855204626917839, 0.01890469156205654, -0.004341500345617533, -0.0008894831407815218, -0.012519950978457928, -0.011516574770212173, 0.02235032245516777, 0.009483715519309044, 0.0037574106827378273, 0.00205246452242136, -0.020442556589841843, 0.07170717418193817, 0.03175576403737068, -0.006745608523488045, -0.009342271834611893, 0.023601869121193886, -0.00613769143819809, -0.031006701290607452, 0.030206739902496338, -0.00431157648563385, -0.022436464205384254, 0.013567887246608734, -0.00025068456307053566, 0.02796023339033127, 0.016532855108380318, -0.026876229792833328, 0.010610777884721756, -0.008048968389630318, -0.0009509650990366936, -0.01626293733716011, 0.01123972050845623, 0.004146423190832138, -0.005387820769101381, 0.012535971589386463, 0.017695806920528412, 0.023571830242872238, -0.0021378907840698957, -0.021012762561440468, -0.014931323006749153, -0.0242970772087574, 0.0030944980680942535, -0.00942876748740673, -0.005538108758628368, -0.006464570760726929, -0.0277946088463068, 0.011552294716238976, -0.029890479519963264, 0.014386411756277084, 0.01922483928501606, 0.007105392403900623, -0.009239600040018559, -0.01913599669933319, -0.00875401683151722, 0.023638630285859108, 0.0030365954153239727, -0.013281544670462608, -0.01444487739354372, -0.004668578039854765, -0.0014084652066230774, -0.013193872757256031, -0.027560196816921234, -0.016979966312646866, -0.014401690103113651, 0.01353013888001442, 0.022856656461954117, -0.002322186017408967, -0.004973238334059715, 0.017311930656433105, -0.02714550495147705, -0.009514600969851017, -0.005808350630104542, 0.004475066438317299, -0.04520326107740402, 0.0295343529433012, 0.0030633697751909494, 0.00381286209449172, -0.01685323938727379, 0.012170769274234772, -0.0023732073605060577, -0.011458163149654865, 0.01011516060680151, 0.004302468150854111, 0.034810420125722885, -0.004304290283471346, -0.0013464009389281273, 0.011190206743776798, -0.00022740662097930908, -0.004003360867500305, 0.001991568598896265, 0.0032338143792003393, -0.050691138952970505, -0.014124151319265366, 0.010044570080935955, -0.015979357063770294, -0.016223378479480743, 0.003789203241467476, 0.01152903400361538, -0.0069375731982290745, -0.07452791184186935, -0.007416941225528717, -0.0008996129035949707, -0.011603718623518944, -0.002214670181274414, 0.02318437024950981, -0.01976197212934494, -0.006240953225642443, 0.008282151073217392, 0.004042151849716902, 0.013464735820889473, 0.005442962981760502, -0.011691369116306305, -0.0057100714184343815, 0.012309355661273003, 0.012216191738843918, -0.004572421312332153, 0.016876613721251488, -0.02478543296456337, 0.003694288432598114, 0.014470530673861504, -0.012095632962882519, -0.004746388643980026, 0.01890532672405243, -0.016066420823335648, -0.0805443525314331, -0.02046492137014866, 0.0167281124740839, -0.023627448827028275, -0.011455239728093147, -0.001791311427950859, 0.013574216514825821, -0.002018168568611145, -0.0016461373306810856, -0.015400798991322517, -0.002391890622675419, 0.002584255300462246, 0.021501481533050537, 0.0010336607228964567, 0.0032767304219305515, -0.005505204666405916, 0.037873830646276474, 0.015575475990772247, -0.032261840999126434, -0.0167689211666584, 0.013687167316675186, 0.022471096366643906, -0.0018230876885354519, -0.01469704881310463, -0.014198627322912216, -0.020621228963136673, 0.0049292161129415035, 0.011654471047222614, 0.0022182660177350044, -0.004744586534798145, -0.0008706445805728436, -0.03685808181762695, -0.02258199453353882, 0.0039739953354001045, -0.008661160245537758, -0.014222067780792713, -0.0009142663329839706, 0.012487560510635376, -0.016846735030412674, 0.009881684556603432, 0.0009105004137381911, 0.024227412417531013, 0.006436842959374189, 0.0010620891116559505, -0.00855826586484909, 0.000359363853931427, 0.00519572151824832, -0.013764406554400921, 0.012370227836072445, 0.026553785428404808, 0.00620369054377079, 0.008992169052362442, 0.011983858421444893, 0.016933567821979523, -0.028775684535503387, -0.002841710578650236, -0.0069676656275987625, 0.015987493097782135, 0.03306368738412857, 0.0037767391186207533, 0.0046457648277282715, -0.017090968787670135, -0.021883320063352585, 0.07107274234294891, -0.027065396308898926, -0.01882004365324974, -0.03437377139925957, 0.0025663196574896574, 0.004312099888920784, -0.01785002276301384, -0.007956682704389095, 0.007539339363574982, 0.005557178519666195, 0.013519318774342537, -0.005628891289234161, 0.008209935389459133, 0.009057479910552502, 0.006163733080029488, -0.015370210632681847, 0.005370927508920431, 0.016979435458779335, 0.008558185771107674, -0.029616674408316612, -0.012428412213921547, 0.024033738300204277, -0.01715954765677452, 0.02116670459508896, 0.01286413986235857, -0.00425372552126646, 0.03760809451341629, 0.01256722491234541, -0.007053880952298641, -0.027059344574809074, -0.030281059443950653, 0.011275745928287506, 0.0034500134643167257, -0.0008910670876502991, 0.004140529315918684, 0.029097942635416985, 0.02725144475698471, 0.004066017456352711, 0.0013129061553627253, -0.0034325486049056053, -0.004155812319368124, 0.022541116923093796, 0.0005285090301185846, -0.009618177078664303, 0.02598538063466549, 0.026552613824605942, 0.006676578428596258, 0.008554920554161072, 0.0006007510237395763, 0.0058364905416965485, -0.01737682707607746, 0.002408824395388365, -0.001548695843666792, 0.004139786586165428, 0.010274538770318031, -0.030716672539711, 0.0008010847959667444, 0.015490906313061714, -0.03018380142748356, -0.01015721820294857, 0.03294150531291962, -0.010121721774339676, 0.003975530620664358, -0.02377958968281746, 0.021007776260375977, -0.002348292153328657, 0.007035115733742714, -0.01762397773563862, -0.026163838803768158, 0.013915264047682285, -0.0007675024680793285, -0.0012992806732654572, 0.004353475756943226, -0.004612857010215521, 0.021669456735253334, -0.005641031078994274, -0.009785502217710018, 0.01047480758279562, 0.009059339761734009, 0.00833434984087944, -0.014867588877677917, -0.0028409624937921762, -0.0005553178489208221, -0.03389304503798485, 0.011656925082206726, 0.01082567684352398, -0.015200034715235233, -0.011472498066723347, -0.004469623323529959, -0.0024859122931957245, -0.004992193076759577, -0.019538873806595802, 0.0007076256442815065, -0.005549252033233643, 0.012581389397382736, 0.03512834757566452, 0.016258183866739273, 0.013837937265634537, -0.0063721779733896255, 0.011991347186267376, 0.00661489088088274, -0.031266555190086365, -0.0065264394506812096, -0.0347699411213398, -0.007049780339002609, 0.008850977756083012, -0.006608474534004927, -0.007226231042295694, 0.0003861989825963974, 0.0033051874488592148, 0.0005290401168167591, -0.020481863990426064, 0.03887992724776268, -0.010699613019824028, -0.00012787384912371635, -0.0040779514238238335, -0.01090194471180439, 0.005994983017444611, 0.029390579089522362, -0.016087204217910767, -0.018755868077278137, -0.02699759602546692, 0.0019297627732157707, 0.020015329122543335, -0.006911993492394686, -0.020152386277914047, -0.008546670898795128, -0.00021791551262140274, -0.01300229225307703, 0.000049656257033348083, 0.016435988247394562, -0.014910202473402023, 0.018180787563323975, -0.002039499580860138, -0.03172094747424126, -0.02247552201151848, 0.004882174544036388, 0.03078613057732582, -0.04542364925146103, -0.014747588895261288, -0.0072494084015488625, -0.0014529165346175432, 0.005628660321235657, 0.013017545454204082, 0.010134667158126831, -0.013392573222517967, 0.017387649044394493, 0.010086431168019772, 0.016637593507766724, -0.009476041421294212, -0.0034208635333925486, -0.00899873673915863, 0.025871267542243004, -0.002712475135922432, 0.0024203979410231113, 0.030360857024788857, 0.00886787660419941, 0.009189680218696594, -0.007687849923968315, -0.005023955833166838, -0.008739247918128967, -0.0024713310413062572, 0.004234865307807922, 0.011350175365805626, 0.0000018524006009101868, 0.006484655663371086, -0.01983710005879402, -0.008824940770864487, 0.014925490133464336, -0.011627103202044964, 0.007642085663974285, -0.014521883800625801, 0.00004407716915011406, 0.011053923517465591, -0.013383481651544571, -0.013135682791471481, 0.005444690585136414, -0.007747347466647625, 0.015253215096890926, 0.02726079896092415, -0.014122280292212963, -0.0043195332400500774, -0.00940458383411169, -0.009631214663386345, 0.00401105172932148, -0.0032351117115467787, -0.0029306886717677116, -0.0019305073656141758, -0.018504757434129715, -0.005226378329098225, -0.019677162170410156, -0.00446407962590456, 0.008420467376708984, 0.011582231149077415, -0.027267541736364365, 0.007286501117050648, -0.02283199317753315, -0.04009556397795677, 0.00849970243871212, 0.009176244959235191, -0.010724574327468872, -0.016697172075510025 ]
[ 0.14086273312568665, -0.12484028935432434, 0.3470945358276367, 0.046921517699956894, 0.35629916191101074, 0.6149367094039917, 0.42911699414253235, 0.29821670055389404, -0.3864322900772095, -0.277385413646698, 0.07863563299179077, -0.023456351831555367, -0.18692666292190552, -0.07302740961313248, 0.1394338309764862, 0.6570603251457214, 0.4767305850982666, 0.4203122556209564, -0.14936251938343048, -0.785498321056366, -0.332279235124588, -0.643746554851532, 0.6910638213157654, 0.12286097556352615, -0.009492876008152962, -0.2757349908351898, 0.3667231798171997, -0.19081997871398926, 0.19067518413066864, -0.3124590814113617, -0.19058823585510254, 0.39355140924453735, 0.3006300926208496, -0.258024126291275, 0.022880414500832558, -0.022268664091825485, 0.3607230484485626, -0.10594382882118225, 0.21962353587150574, -0.0018447507172822952, -0.32531532645225525, -0.5646070241928101, 0.26280999183654785, 0.371259480714798, -0.19243597984313965, -0.10871490091085434, -1.1754541397094727, 0.4839969873428345, -0.04328195005655289, -0.16107511520385742, 0.30116599798202515, 0.22464941442012787, 0.7615512609481812, 0.13605047762393951, 0.1683846116065979, 0.013649681583046913, -0.4229390621185303, -0.23088760673999786, 0.10225983709096909, -0.5905289649963379, 0.3479309678077698, 0.17753994464874268, 0.10575263947248459, -0.15779618918895721, -0.12268366664648056, 0.12758778035640717, 0.09827300906181335, 0.14602121710777283, -0.22944648563861847, 0.09855922311544418, 0.2690771222114563, -0.32439953088760376, -0.12321693450212479, -0.03594524413347244, 0.12735791504383087, 0.20859549939632416, -0.28496024012565613, -0.11175824701786041, 0.5996205806732178, -0.37754693627357483, 0.10507160425186157, -0.09770140051841736, 0.32477515935897827, 0.3209672272205353, 0.22684204578399658, 0.4436599314212799, -0.00112247618380934, 0.489108681678772, 0.10988595336675644, 0.10829360038042068, -0.4115440547466278, -0.25684186816215515, 0.09589783102273941, 0.41508087515830994, -0.16154809296131134, 0.4899774491786957, -0.025639884173870087, -0.109248585999012, 0.3974589407444, 0.013749794103205204, -0.5482921004295349, -0.10868419706821442, -0.31400784850120544, -0.4753887951374054, -0.38658371567726135, 0.04153937101364136, 0.057204145938158035, 0.05839839205145836, -0.6470955610275269, 0.11909733712673187, -1.129516839981079, -0.32458850741386414, -0.0013182340189814568, -0.28899461030960083, -0.44707298278808594, -0.030370963737368584, -0.13612569868564606, -0.3971730172634125, -0.008954698219895363, 0.20769988000392914, -0.2989811599254608, 0.37179064750671387, -0.2701869010925293, 0.1309773474931717, -0.03386839106678963, 0.4757031798362732, 0.3719271123409271, 0.3066020905971527, 0.34492966532707214, 0.4724214971065521, 0.4328565299510956, 0.3944209814071655, -0.3615201413631439, 0.41158705949783325, 0.30432620644569397, -0.4303032457828522, 0.029551755636930466, 0.21369034051895142, 0.5568897724151611, 0.3945690393447876, -0.5440603494644165, -0.5208154916763306, -0.019427750259637833, 0.20327667891979218, 0.26030880212783813, -0.33576586842536926, -0.1609206646680832, 0.16394104063510895, 0.20886261761188507, -0.40719351172447205, -0.10957285016775131, -0.2369045913219452, -0.3185122013092041, -0.12357112020254135, -0.11498017609119415, 0.273140549659729, 0.05149533972144127, -0.5406321287155151, -0.2917320728302002, 0.07840269058942795, 0.4081984758377075, 0.6408208012580872, -0.3302968442440033, 0.14378118515014648, 0.8152238726615906, 0.0728522315621376, 0.06013800948858261, 0.19356100261211395, -0.3267121911048889, 0.3592938780784607, -0.43001338839530945, -0.106064073741436, -0.20081838965415955, -0.8105616569519043, -0.34317389130592346, 0.4799104928970337, 0.10889752954244614, -0.04094594717025757, 0.2358802706003189, -0.17946040630340576, -0.5776882767677307, 0.3153793215751648, 0.07966030389070511, -0.4627991020679474, 0.11540905386209488, 0.10816967487335205, -0.02659022994339466, 0.07174745947122574, -0.07952279597520828, -0.25506502389907837, 0.1869175285100937, -0.2725673317909241, 0.7482048273086548, -0.6331813335418701, 1.2090786695480347, -0.6417158842086792, -0.16267278790473938, 1.038258671760559, 0.3763945996761322, -0.02147737704217434, 0.23729217052459717, 0.10341472923755646, 0.6219754219055176, -0.14740385115146637, -0.8313455581665039, 0.44238293170928955, 0.017445173114538193, -0.09216690063476562, 0.27994316816329956, -0.09579535573720932, 0.47195354104042053, 0.016477033495903015, -0.24504630267620087, 0.055602580308914185, 0.01235354132950306, -0.04323640093207359, -0.12692628800868988, -0.044017501175403595, 0.16749970614910126, -0.06895862519741058, 0.3185610771179199, -0.5801343321800232, 0.41971540451049805, 0.47902363538742065, -0.43337830901145935, 0.6239361763000488, 0.5838337540626526, 0.0019280067645013332, 0.5847359895706177, -0.28983741998672485, 0.25309085845947266, 0.050029199570417404, -0.04647529125213623, -0.24526739120483398, -0.03356774523854256, -0.10191270709037781, -0.23058731853961945, -0.37157219648361206, -0.18187569081783295, 0.17004020512104034, -0.22196267545223236, 0.6248888373374939, -0.6365782618522644, -0.15575727820396423, -0.08078034222126007, -0.5751321911811829, -0.3036310076713562, 0.5240384340286255, -0.630204975605011, 0.1764032542705536, 0.010796144604682922, 0.335992693901062, -0.22072923183441162, -0.03784962743520737, -0.19517986476421356, 0.2924777567386627, -0.1944035440683365, -0.6258694529533386, -0.2060120403766632, -0.35509058833122253, -0.1656036376953125, 0.19457778334617615, 0.02679901383817196, 0.5128891468048096, -0.06194834038615227, -0.6808285713195801, -0.6681503057479858, -0.3468858301639557, 1.072765588760376, 0.5213794708251953, 0.552790641784668, 0.11874882876873016, -0.6513251066207886, 0.1426101177930832, -0.05156860128045082, -0.36072221398353577, -0.17314839363098145, 0.7336474657058716, -0.5485390424728394, -0.16461589932441711, -0.0012055333936586976, 0.47278517484664917, 0.7963981032371521, 0.05851459503173828, -0.17364460229873657, -0.12192688137292862, 0.12526798248291016, -0.1687578558921814, -0.09746959805488586, -0.3080021142959595, -0.20955300331115723, 0.49412351846694946, -0.15491771697998047, -0.2970390021800995, 0.841596245765686, 0.24130472540855408, 0.1458355188369751, 0.6870379447937012, 0.5036777257919312, -0.029257887974381447, -0.03114859014749527, 0.39369192719459534, 0.6318151354789734, -0.5223039984703064, -0.1485089510679245, 0.4273601770401001, -0.4677176773548126, -0.21496233344078064, -6.102046966552734, 0.4011539816856384, -0.3489212989807129, -0.6565926671028137, -0.14112915098667145, 0.004569592885673046, 0.9808053970336914, 0.23533698916435242, 0.17828857898712158, -0.005237748846411705, 0.4086085855960846, 0.770056962966919, 0.09770924597978592, 0.1593056321144104, -0.21738620102405548, -0.017185905948281288, -0.19046100974082947, -0.39758825302124023, 0.4329608976840973, 0.020201414823532104, -0.435321569442749, -0.09679928421974182, 0.0966392233967781, 0.5778909921646118, 0.38979530334472656, 0.49905508756637573, -1.0213412046432495, 0.27194371819496155, -0.2208918333053589, -0.3069332242012024, 0.08673044294118881, -0.5268180966377258, 0.04762791842222214, -0.24719522893428802, 0.07535435259342194, -0.07626930624246597, 0.2395983636379242, 0.0012146536028012633, 0.16845370829105377, -0.3226839601993561, -0.11868245899677277, -0.16830036044120789, -0.40047845244407654, 0.018894633278250694, -0.05105532333254814, 0.06778445839881897, 0.06102754920721054, 0.33159536123275757, -0.1328277438879013, 0.8444634675979614, 0.19351239502429962, 0.11167853325605392, 0.03913018852472305, 0.4022432863712311, 0.4975569546222687, 0.4521469175815582, -0.16375698149204254, 0.4232388138771057, -0.16505347192287445, 0.34147152304649353, 0.17693252861499786, 0.16701199114322662, -0.11687159538269043, -0.5947339534759521, -0.2278514951467514, 0.15151889622211456, -0.7060416340827942, -0.05416499450802803, 0.5125765800476074, -0.03168008103966713, -0.2252711057662964, 0.04380723461508751, 0.3493538796901703, -0.7317208647727966, 0.4512341618537903, -0.7333843111991882, 0.25738680362701416, 0.3907247483730316, 0.2832315266132355, -0.5771210193634033, -0.0950719341635704, -0.07074403762817383, 0.40899208188056946, -0.28764957189559937, -0.02354356087744236, 0.10543781518936157, -0.06811399757862091, -0.003233006689697504, 0.09862557053565979, 0.2538897395133972, 0.3779754042625427, -0.08828096091747284, 0.028184518218040466, -0.006387938745319843, 0.40353307127952576, 0.8095763921737671, 0.5853667855262756, 0.3271408677101135, 0.2524595260620117, -0.09410802274942398, 0.9463095664978027, -0.5015349388122559, -0.42983198165893555, -0.9466262459754944, -0.23411686718463898, -0.023044351488351822, -0.7192946672439575, 0.07790587097406387, 0.3168288767337799, -0.5419697165489197, 0.26085302233695984, -0.38262268900871277, -0.2657175362110138, -0.3396071195602417, 0.77580726146698, -0.09595663845539093, -0.22206677496433258, -0.03478178754448891, 0.6279348134994507, -0.1767880767583847, 0.31470224261283875, 0.2114996463060379, -0.47104158997535706, 0.4036979675292969, 0.12593171000480652, 0.011058717034757137, 0.2089110165834427, 0.5148195028305054, -0.9914913177490234, -0.17721909284591675, -0.007581766229122877, 0.5682502388954163, -0.23950916528701782, -0.06353595852851868, 0.1868271678686142, -0.12879572808742523, -0.26653212308883667, 0.29021140933036804, 0.5854648351669312, 0.23305268585681915, 0.05949385091662407, 0.1125519797205925, -0.6756159663200378, 0.15294179320335388, 0.12629853188991547, -0.2940419018268585, -0.24916210770606995, 0.09029945731163025, 0.07450106739997864, -0.033225756138563156, 0.4040882885456085, -0.28739047050476074, 0.4336652457714081, -0.060030363500118256, -0.6861820816993713, -0.031545963138341904, -0.059578027576208115, -0.04692981019616127, -0.3614013195037842, -0.7011452317237854, 0.2956176698207855, -0.2586509585380554, -1.093522310256958, -0.3320286273956299, 0.06186124309897423, -0.6649287343025208, 0.1812051385641098, -0.8517563939094543, -0.24272584915161133, 0.10972894728183746, -0.1277151107788086, -0.26932552456855774, 0.4476888179779053, -0.04245682433247566, 0.47541865706443787, -0.2508813142776489, -0.5800970196723938, -0.3536128103733063, 0.03721212223172188, 0.2679985761642456, 0.011784723959863186, -0.16061952710151672, -0.0777440220117569, -0.10184476524591446, 0.4176081418991089, 0.7420774698257446, 0.2333897054195404, -0.11463019251823425, -0.20090357959270477, 0.10563311725854874, 0.13860580325126648, -0.033347759395837784, 0.16391949355602264, -0.22965343296527863, -0.18063758313655853, 0.436002641916275, 0.03683209791779518, 0.7270737886428833, 0.0960564836859703, -0.011519466526806355, -0.196963369846344, 0.3612537086009979, -0.27422407269477844, 0.360196977853775, 0.6548162698745728, -0.10540977865457535, 0.06360204517841339, -0.31549808382987976, -0.55787593126297, -0.28067752718925476, -0.035885781049728394, -0.39589381217956543, -0.11377297341823578, 0.1057957336306572, -0.5386460423469543, 0.2648804783821106, -0.007839393801987171, -0.4038618803024292, -0.3238890469074249, 0.4654672145843506, 0.3053910732269287, -0.22829082608222961, 0.0383753664791584, 0.036883365362882614, -0.1046718880534172, 0.361417293548584, 0.6884369254112244, -0.876223623752594, 0.32074132561683655, 0.22488456964492798, -0.5497283935546875, -0.22904522716999054, 0.09596873074769974, -0.13342730700969696, -0.3966858685016632, -0.24897253513336182, -0.17230337858200073, -0.18618321418762207, -0.17059847712516785, 0.03558332473039627, 0.1628098487854004, 0.540818989276886, -0.2639114558696747, -0.8080917000770569, 0.0006459291907958686, -0.13336262106895447, 0.4833657145500183, -0.9635298252105713, 0.18907205760478973, 0.17921119928359985, 0.5560466051101685, -0.3216696083545685, 0.2763082683086395, 0.08481521904468536, 0.04189957305788994, 0.07961612194776535, -0.23726220428943634, -0.281305193901062, 0.1334729790687561, 0.36187005043029785, -0.267513245344162, -0.6715953946113586, 0.010850757360458374, 0.009924154728651047, 0.1864173412322998, -0.056981105357408524, -0.01992618851363659, -0.30659908056259155, 0.08730844408273697, -0.03418760746717453, 0.23712657392024994, -0.0009315432980656624, 0.886829674243927, 0.1979042887687683, -0.06373525410890579, -0.09674686193466187, -0.4418741762638092, 0.11957685649394989, 0.03096918575465679, 0.4548328220844269, -0.6285831332206726, -0.5620712041854858, -0.005121598485857248, -0.21701088547706604, 0.10351382195949554, -0.5472221374511719, 0.548502504825592, -0.08559807389974594, -0.46174341440200806, -0.4535462260246277, 0.13072432577610016, 0.03537454083561897, -0.6046590209007263, -0.533855676651001, 0.26224708557128906, 0.1588183343410492, 0.15169398486614227, 0.5710763335227966, 0.22438944876194, -0.17844942212104797, -0.30981287360191345, 0.7012556195259094, 0.27626457810401917, -0.6042613983154297, 0.37831276655197144, 0.15138646960258484, -0.043187111616134644, -0.4523812532424927, -0.2154943197965622, 0.11189958453178406, 0.13845472037792206, -0.08046174794435501, 0.03467240557074547, 0.3082829415798187, -0.03761467710137367, -0.065182626247406, -0.5938521027565002, -0.4229423999786377, 0.44200584292411804, 0.2629716396331787, 0.30102914571762085, 0.7489848732948303, 0.5896400213241577, 0.12084038555622101, -0.2395060956478119, 0.35577091574668884, 0.1201310008764267, 0.3600163459777832, 0.19133183360099792, 0.508162260055542, 0.6168308258056641, 0.5644668936729431, 0.03946463018655777, 0.5200983285903931, 0.0014330883277580142, 0.29312577843666077, -0.1619233787059784, -0.7603903412818909, -0.14633136987686157, -0.21081502735614777, 0.7201767563819885, 0.22842827439308167, 0.2664888799190521, -0.3454161286354065, 0.12238951027393341, 0.47318559885025024, -0.2939825654029846, 0.02961891144514084, -0.007525852415710688, -0.15688948333263397, 0.3857995867729187, -0.6409727334976196, -0.30132731795310974, -0.13179613649845123, -0.28899407386779785, 0.27196288108825684, -0.09203721582889557, 0.06164572387933731, -0.6740753054618835, -0.040068402886390686, -0.2645624279975891, -0.08047429472208023, -0.1098945364356041, 0.3460683524608612, -0.08450078219175339, -0.10380760580301285, 0.2803282141685486, 0.4056386649608612, 0.07520170509815216, -0.38215065002441406, -0.18330073356628418, -0.261178195476532, -0.41745293140411377, 0.06022199988365173, 0.1492813378572464, -0.523819088935852, -0.1644023358821869, 0.15662506222724915, 0.10258276760578156, 0.38681232929229736, -0.5130000114440918, 0.2727048695087433, 0.133671835064888, -0.2869476079940796, 0.055800724774599075, -0.6494097113609314, -0.35412678122520447, -0.2240859568119049, -0.03099060244858265, 0.17132070660591125, 0.17824028432369232, -0.3208337426185608, 0.2369217574596405, 0.15296462178230286, 0.02133997716009617, -0.533291757106781, -0.009639028459787369, 0.29239916801452637, 0.46440422534942627, 0.18073423206806183, -0.336686372756958, 0.09011755883693695, 0.11721552908420563, 0.12480167299509048, -0.30523544549942017, 0.021343853324651718, -0.32420846819877625, 0.053424254059791565, -0.5611492395401001, -0.2812928557395935, 0.34816840291023254, 0.4022107422351837, -0.4242919683456421, 0.3478953242301941, 0.230401411652565, 0.21876280009746552, 0.6372389197349548, -0.14588391780853271, -0.3701481819152832, -0.46455541253089905, -0.33211395144462585, -0.6638507843017578, 0.6854367852210999, 0.011999989859759808, -0.16486623883247375, 0.08181450515985489, 0.031182248145341873, 0.36958324909210205, -0.21347957849502563, 0.7731156349182129, -0.6075778603553772, -0.2993205189704895, -0.5763691663742065, 0.4632008969783783, -0.3258064091205597, 0.3549351990222931, 0.30556169152259827, -0.06333953142166138, -0.05728687345981598, -0.1580708920955658, -0.40188759565353394, -0.49972712993621826, 0.2655438780784607, 0.029273273423314095, 0.2730323374271393, 0.23136167228221893, -0.07760313153266907, -0.25257670879364014, -0.9476959705352783, 0.13638699054718018, -0.2470826357603073, -0.43195903301239014, 0.16476190090179443, -0.14036542177200317, -0.36290350556373596, -0.10806966572999954, 0.027205197140574455, -0.4403270184993744, -0.5998090505599976, -0.10494530946016312 ]
The oxidative pentose phosphate pathway (PPP) contributes to tumour growth, but the precise contribution of 6-phosphogluconate dehydrogenase (6PGD), the third enzyme in this pathway, to tumorigenesis remains unclear. We found that suppression of 6PGD decreased lipogenesis and RNA biosynthesis and elevated ROS levels in cancer cells, attenuating cell proliferation and tumour growth. 6PGD-mediated production of ribulose-5-phosphate (Ru-5-P) inhibits AMPK activation by disrupting the active LKB1 complex, thereby activating acetyl-CoA carboxylase 1 and lipogenesis. Ru-5-P and NADPH are thought to be precursors in RNA biosynthesis and lipogenesis, respectively; thus, our findings provide an additional link between the oxidative PPP and lipogenesis through Ru-5-P-dependent inhibition of LKB1-AMPK signalling. Moreover, we identified and developed 6PGD inhibitors, physcion and its derivative S3, that effectively inhibited 6PGD, cancer cell proliferation and tumour growth in nude mice xenografts without obvious toxicity, suggesting that 6PGD could be an anticancer target.
[ -0.031013891100883484, 0.004759528674185276, -0.013682782649993896, 0.018285831436514854, -0.003383966162800789, -0.0032391157001256943, 0.010654313489794731, -0.005866639316082001, -0.010534586384892464, -0.034307725727558136, -0.016345949843525887, -0.0004713749513030052, -0.023949824273586273, 0.018284380435943604, 0.0036807325668632984, 0.0118359150364995, -0.008309893310070038, -0.00347764790058136, 0.010814380832016468, 0.018564734607934952, 0.008098459802567959, -0.004104694817215204, 0.010889563709497452, -0.0190909281373024, -0.00472521036863327, -0.004417462274432182, 0.019710810855031013, -0.007593919523060322, -0.0008243845659308136, -0.015133109875023365, 0.01049439050257206, 0.003013686975464225, 0.012739953584969044, -0.026319459080696106, 0.009112122468650341, -0.006250014994293451, -0.007615553680807352, 0.012173190712928772, 0.025850636884570122, -0.00567738339304924, -0.011604657396674156, -0.018122553825378418, -0.0035282685421407223, -0.008118200115859509, -0.009985147044062614, -0.007544495165348053, -0.0021991245448589325, -0.006472176872193813, 0.0027506675105541945, 0.01113138161599636, -0.010281975381076336, -0.027012936770915985, -0.01745115965604782, 0.0015913499519228935, -0.006320193409919739, -0.012091624550521374, 0.018911002203822136, 0.0174110010266304, 0.0026930198073387146, -0.01143777184188366, 0.007734064012765884, -0.0511663481593132, 0.023342061787843704, -0.025161858648061752, -0.022148236632347107, -0.06673076003789902, 0.023984286934137344, -0.01813432015478611, -0.020238041877746582, 0.00923791155219078, 0.009081386961042881, 0.010202942416071892, 0.01769125461578369, 0.0012130443938076496, -0.004097983706742525, -0.002661102917045355, -0.004145408980548382, 0.016374865546822548, -0.01038341224193573, 0.01844193786382675, -0.02650764398276806, -0.03251951187849045, -0.017699815332889557, 0.011792901903390884, -0.00928439199924469, 0.023683182895183563, -0.027412600815296173, -0.012416040524840355, -0.01600179634988308, -0.0007732603698968887, 0.02232697606086731, 0.00013413955457508564, 0.003009658306837082, -0.0022756424732506275, -0.01956586353480816, -0.0016008059028536081, -0.02598906308412552, -0.016269005835056305, -0.0021830848418176174, -0.023073408752679825, -0.020232990384101868, -0.029948893934488297, 0.01989254355430603, -0.005343585275113583, 0.023332174867391586, 0.0018060338916257024, -0.008325668051838875, 0.035478636622428894, 0.04177612066268921, 0.008882451802492142, -0.008625463582575321, 0.021263249218463898, 0.004154562018811703, 0.005078958347439766, 0.030951358377933502, 0.007903475314378738, -0.014306670054793358, 0.01078762300312519, 0.019792772829532623, 0.006563473492860794, 0.019606804475188255, -0.0005742060020565987, -0.008423686027526855, 0.03656456992030144, 0.001693420228548348, 0.011108122766017914, 0.030342688784003258, 0.011403478682041168, 0.00940612331032753, 0.006095916498452425, -0.009887868538498878, -0.005857547745108604, -0.016319353133440018, 0.01156442891806364, 0.026763200759887695, 0.0029224599711596966, 0.016457436606287956, -0.012499921023845673, -0.00022984249517321587, -0.003917222376912832, -0.0012724772095680237, 0.005786414723843336, 0.000818244821857661, 0.013428364880383015, 0.014612071216106415, 0.006565491668879986, -0.003087712451815605, -0.004677853547036648, 0.007646907586604357, -0.003262047888711095, 0.001770135946571827, 0.030558371916413307, 0.00009213219163939357, -0.02110680565237999, 0.028616994619369507, -0.0005979933775961399, -0.02434329316020012, -0.02261776104569435, -0.009914116933941841, 0.0012246742844581604, -0.047599922865629196, 0.002003646921366453, 0.020840926095843315, 0.00966646522283554, -0.0044954800978302956, -0.03579695522785187, -0.021937526762485504, -0.013982112519443035, 0.004281395114958286, 0.00824805535376072, -0.006556533742696047, -0.019759248942136765, -0.00006979191675782204, 0.011513881385326385, -0.02172095701098442, 0.0011825417168438435, 0.008318361826241016, 0.007837068289518356, 0.00004245166201144457, 0.06596360355615616, -0.024369368329644203, 0.03552453964948654, -0.009491579607129097, -0.01263135951012373, 0.020337987691164017, -0.031066183000802994, 0.012572256848216057, -0.007488042116165161, -0.0009802253916859627, 0.033023182302713394, 0.00777252996340394, 0.013297326862812042, -0.020411139354109764, 0.03089592233300209, -0.016489412635564804, 0.003044331446290016, 0.0027597500011324883, -0.003493145341053605, -0.0022232336923480034, -0.009864887222647667, 0.016284555196762085, -0.017724575474858284, -0.000610011164098978, -0.038856979459524155, 0.010829733684659004, 0.006209193728864193, -0.04067675396800041, -0.03361789137125015, -0.01499443780630827, -0.005665251985192299, 0.03359100967645645, -0.02605428546667099, -0.0042821262031793594, -0.004186796024441719, 0.007723070681095123, 0.002752996049821377, -0.03602068871259689, 0.025401730090379715, -0.004509780555963516, -0.008125051856040955, -0.0014437190257012844, 0.0266006700694561, 0.027699396014213562, 0.01486583799123764, 0.019612308591604233, -0.007970832288265228, 0.006340417079627514, 0.014661632478237152, 0.005307261366397142, -0.008781430311501026, 0.015652332454919815, -0.023539725691080093, -0.01620165817439556, 0.031627800315618515, 0.03373030573129654, 0.016074519604444504, 0.01788099855184555, -0.029055697843432426, 0.019909538328647614, -0.01890753209590912, -0.003433654783293605, 0.004010564647614956, 0.027692055329680443, -0.002265599090605974, 0.022834472358226776, -0.000280707492493093, 0.008170971646904945, 0.02415720745921135, 0.008402848616242409, -0.010265693068504333, 0.010608552955091, 0.0004884558729827404, 0.018382355570793152, -0.02094830945134163, 0.004299595952033997, -0.01587442308664322, -0.014925211668014526, -0.010738072916865349, 0.026439161971211433, -0.0364915207028389, -0.0020864205434918404, 0.007832261733710766, 0.011895308271050453, -0.028368275612592697, -0.010701636783778667, 0.018350981175899506, 0.006528502330183983, -0.01816018670797348, -0.012992212548851967, 0.0012640636414289474, 0.012478391639888287, -0.006462751887738705, -0.008928501047194004, -0.08144808560609818, -0.01567068323493004, -0.015491429716348648, 0.002747712656855583, 0.009033143520355225, -0.004277808591723442, 0.026274753734469414, -0.014648145996034145, -0.024472754448652267, -0.0020955889485776424, 0.004371960647404194, 0.004153156187385321, 0.0002033913042396307, -0.009473438374698162, 0.007090261206030846, -0.01179275568574667, 0.011207057163119316, 0.005053054075688124, 0.005524331703782082, -0.03029692731797695, 0.007667100057005882, 0.013943085446953773, -0.0017840242944657803, -0.009653143584728241, -0.04508104920387268, 0.0190661009401083, -0.012422675266861916, 0.012859158217906952, 0.001927774166688323, 0.0001692353398539126, -0.004687664099037647, -0.035951606929302216, -0.026903757825493813, -0.016980895772576332, -0.010219698771834373, -0.000802654423750937, 0.010522411204874516, -0.00864952988922596, -0.027552403509616852, 0.04265798255801201, -0.020354339852929115, 0.003141057677567005, 0.014541959390044212, -0.0017321566119790077, 0.015447871759533882, 0.02802538312971592, 0.01805475540459156, 0.006546902470290661, 0.017961185425519943, -0.010453514754772186, -0.0011165065225213766, 0.016955338418483734, -0.006538474000990391, 0.02037622779607773, -0.010120326653122902, -0.034108567982912064, 0.00703559210523963, -0.00880710780620575, -0.014045764692127705, -0.01772719994187355, -0.008389487862586975, -0.013828776776790619, 0.029081232845783234, 0.006209371145814657, -0.008181966841220856, 0.014943882822990417, 0.012556085363030434, -0.010551278479397297, -0.011030212044715881, 0.008943778462707996, -0.008929919451475143, 0.0006113739218562841, -0.018758069723844528, -0.0015629339031875134, -0.003442017827183008, -0.013313360512256622, -0.01689877361059189, -0.028206858783960342, -0.0057891421020030975, -0.004318279679864645, -0.005854904651641846, 0.0013870447874069214, -0.01607157103717327, 0.00933152250945568, -0.01950937882065773, 0.014769468456506729, 0.002931371098384261, 0.03034612163901329, 0.012186422944068909, -0.0169929638504982, -0.0036827384028583765, 0.018199387937784195, 0.010307763703167439, 0.012055153027176857, -0.0014499893877655268, -0.052349068224430084, 0.007130117155611515, -0.006727313622832298, 0.024934841319918633, 0.008127579465508461, -0.0174119733273983, 0.001465640147216618, 0.039664532989263535, -0.013399804010987282, -0.043799661099910736, 0.01136779971420765, -0.012756175361573696, 0.006436352152377367, -0.02169353887438774, 0.0031711694318801165, -0.04355095326900482, -0.015453919768333435, -0.004161031451076269, 0.0473046638071537, 0.0045149740763008595, -0.033396437764167786, -0.005457882769405842, -0.0025987550616264343, 0.07239998877048492, 0.007324500475078821, -0.0018899822607636452, -0.0037536213640123606, -0.008142039179801941, -0.012679966166615486, -0.02561463788151741, 0.015894867479801178, 0.0028474866412580013, 0.008341599255800247, 0.013873979449272156, 0.0028296844102442265, -0.004596874117851257, 0.0007882860954850912, -0.022923335433006287, 0.016550440341234207, -0.03183326870203018, 0.006088888272643089, 0.02385285496711731, -0.010530244559049606, -0.013749191537499428, -0.03377794846892357, 0.00041670864447951317, -0.005265442654490471, -0.011442484334111214, -0.014505032449960709, 0.016149714589118958, -0.009817935526371002, -0.02180500328540802, 0.011854469776153564, -0.01323498971760273, 0.0256744883954525, -0.009353311732411385, 0.016949672251939774, 0.0027938704006373882, 0.009835818782448769, 0.010119172744452953, -0.010293940082192421, -0.014077220112085342, -0.0011120883282274008, -0.040179990231990814, -0.017515596002340317, -0.00225231796503067, -0.0034535108134150505, -0.03820108622312546, 0.00828159973025322, 0.012239817529916763, -0.010842446237802505, 0.015514479018747807, 0.0001705345930531621, -0.00976616982370615, -0.0050525362603366375, 0.006728421431034803, -0.01163651142269373, -0.032310567796230316, -0.030342143028974533, 0.016035282984375954, -0.00659586675465107, -0.0012295735068619251, -0.005006888881325722, -0.01005383301526308, 0.020059451460838318, 0.02793850377202034, -0.04206142574548721, 0.012227630242705345, -0.0162208192050457, -0.013780566863715649, -0.011764783412218094, 0.00699184276163578, -0.014659943990409374, 0.009259766899049282, 0.005668500438332558, -0.01234801672399044, 0.010347794741392136, -0.02392774447798729, 0.040582239627838135, -0.011176027357578278, -0.013306724838912487, 0.009159764274954796, -0.028140999376773834, 0.010168499313294888, 0.013918599113821983, -0.02040770649909973, -0.012764696031808853, 0.027237985283136368, 0.004869695752859116, -0.0002874454949051142, -0.07519388943910599, -0.013461454771459103, -0.022768927738070488, -0.004930494353175163, -0.012499494478106499, 0.034325823187828064, -0.019705884158611298, -0.033104058355093, 0.02349555492401123, -0.006823784671723843, 0.01648128032684326, 0.016351589933037758, 0.004832002334296703, -0.0295359268784523, 0.01518192794173956, 0.016337141394615173, 0.0014287647791206837, 0.0012822544667869806, -0.007772377226501703, -0.002028414513915777, 0.03529898822307587, 0.029351208359003067, -0.01797354780137539, 0.00003072945401072502, -0.016933172941207886, -0.0810738131403923, -0.005415854975581169, 0.0034684091806411743, -0.010664066299796104, -0.007227191235870123, -0.014176953583955765, 0.0006890236400067806, -0.011735336855053902, 0.01463169977068901, -0.0163879431784153, -0.012561476789414883, -0.014471286907792091, 0.018176976591348648, 0.0011563219595700502, -0.0058066025376319885, -0.011400002986192703, 0.007454707287251949, 0.015131295658648014, -0.023089397698640823, 0.010816050693392754, 0.0051843104884028435, -0.0047473786398768425, -0.011774159036576748, -0.024459274485707283, -0.010529864579439163, -0.011574465781450272, 0.001970623154193163, 0.013450849801301956, 0.004386933520436287, -0.027996791526675224, -0.02382499724626541, -0.02423534169793129, -0.007086923811584711, -0.025634560734033585, 0.002578079467639327, -0.018474748358130455, 0.022341027855873108, 0.004656774923205376, -0.007118961773812771, -0.022711332887411118, -0.004227365832775831, 0.023141056299209595, -0.01294948160648346, 0.008407129906117916, -0.02055724523961544, -0.01574351079761982, 0.006715663708746433, -0.012561322189867496, 0.019844744354486465, -0.03846239671111107, -0.00029987332527525723, -0.01925182156264782, -0.01817496120929718, -0.015887491405010223, -0.005431937053799629, -0.0076792556792497635, -0.008174346759915352, -0.005296942312270403, 0.018486056476831436, 0.00559590756893158, -0.001469069509766996, -0.0012499693548306823, 0.01504452247172594, 0.07090134918689728, -0.0018155728466808796, -0.009479686617851257, -0.024304743856191635, -0.009758512489497662, 0.0091674430295825, -0.02124941349029541, -0.016715554520487785, 0.0026320782490074635, 0.0036724209785461426, -0.0014855973422527313, -0.004902821034193039, -0.006447872146964073, 0.014547480270266533, 0.00863817147910595, -0.014274587854743004, 0.0189952589571476, 0.03289010003209114, 0.006205507554113865, -0.014439841732382774, -0.009154862724244595, 0.019024023786187172, -0.022952070459723473, 0.025865547358989716, 0.011241680011153221, -0.026945844292640686, -0.01524156704545021, -0.01970430463552475, -0.0007909297710284591, 0.005345797166228294, 0.03314782679080963, -0.0007265014573931694, 0.001592337153851986, 0.01486606802791357, 0.016035547479987144, 0.0696200430393219, 0.0211930051445961, 0.01581307128071785, -0.028403455391526222, -0.037108469754457474, 0.008328767493367195, -0.0022429069504141808, 0.0019402424804866314, -0.008609484881162643, 0.0035844785161316395, -0.021632259711623192, 0.013356123119592667, 0.008861478418111801, -0.020839355885982513, 0.005994733422994614, -0.0018172874115407467, -0.005103953182697296, -0.0012011812068521976, 0.005928677972406149, 0.010451076552271843, 0.0016225967556238174, -0.013746486976742744, 0.0038002615328878164, -0.002436521928757429, -0.010474903509020805, 0.019214637577533722, -0.003907723352313042, 0.0035392791032791138, -0.022928327322006226, 0.029122119769454002, -0.014810342341661453, 0.0054725175723433495, -0.014830514788627625, -0.00738473329693079, 0.015547932125627995, 0.009042268618941307, -0.01743883639574051, 0.015010381117463112, 0.011240197345614433, 0.035323988646268845, 0.0026496518403291702, 0.014105547219514847, 0.004801404196768999, 0.03593944013118744, 0.008830578066408634, -0.0188001599162817, 0.00447868974879384, 0.01756787672638893, -0.001048845355398953, -0.01119094155728817, 0.01605396717786789, 0.032499149441719055, -0.010422752238810062, -0.0009623856749385595, 0.0086526433005929, 0.007179356645792723, 0.004838460125029087, 0.006546449847519398, 0.008861737325787544, 0.008506575599312782, 0.03498334065079689, 0.02347576431930065, 0.004997250624001026, 0.022540349513292313, 0.007626917213201523, 0.014869680628180504, -0.04255838692188263, -0.03579290211200714, 0.011434460058808327, -0.022294996306300163, 0.009183797053992748, 0.011257588863372803, -0.03106256201863289, 0.008687669411301613, -0.002012282842770219, 0.01332680881023407, -0.019001208245754242, 0.015375032089650631, 0.011292025446891785, 0.015662141144275665, 0.05488017946481705, -0.02013210952281952, 0.027405768632888794, 0.03428369015455246, -0.018408942967653275, 0.0033916733227670193, -0.0033172154799103737, 0.0008132066577672958, 0.021924588829278946, -0.02977580949664116, -0.006898346357047558, -0.018811408430337906, -0.0066080112010240555, 0.006702736485749483, 0.004017733968794346, 0.02625337801873684, -0.030420325696468353, -0.019517138600349426, 0.00889620091766119, -0.009286627173423767, 0.005070129409432411, -0.021894363686442375, -0.02783893793821335, -0.012918852269649506, 0.032027605921030045, -0.008092403411865234, -0.010073641315102577, 0.0027981402818113565, 0.0055343047715723515, 0.007384626194834709, -0.002886518370360136, 0.027288347482681274, 0.005108820274472237, 0.00817473791539669, -0.019951533526182175, 0.018793001770973206, 0.014308007434010506, 0.004944961052387953, -0.005625738762319088, -0.0419655404984951, 0.00985596515238285, 0.01206667535007, 0.007204642053693533, 0.00037998659536242485, -0.019270364195108414, -0.0029215672984719276, 0.015133310109376907, -0.008720102719962597, -0.011598329059779644, 0.028398167341947556, 0.011866150423884392, 0.00224527926184237, -0.007134083658456802, -0.0006703874096274376, -0.003227140288800001, 0.019060753285884857, 0.014635053463280201, -0.010377280414104462, 0.008014615625143051, -0.0190216526389122, 0.003976090811192989, -0.01681504212319851, -0.015988605096936226, 0.017831087112426758, 0.023420991376042366, 0.02036680281162262, -0.025916699320077896, 0.009125906974077225, -0.011870845220983028, -0.013731669634580612, -0.013198149390518665, -0.0005064683500677347, -0.002474179258570075, -0.01055500004440546, 0.013336589559912682, -0.031703490763902664, 0.005695512518286705, 0.004407935775816441, -0.009060549549758434, -0.00415467657148838, -0.017245879396796227, 0.029507536441087723, -0.02181188575923443, 0.0020676120184361935, -0.0019232050981372595, 0.019156258553266525, -0.006267222575843334 ]
[ -0.3043285310268402, 0.23121486604213715, 0.46069949865341187, -0.109139084815979, -0.23731368780136108, -0.20088253915309906, -0.13764208555221558, -0.37518054246902466, -0.19872623682022095, -0.27579036355018616, 0.027219120413064957, 0.06547413021326065, -0.5631223320960999, 0.16694748401641846, 0.29120275378227234, 0.7482804656028748, 0.6543003916740417, 0.5855246782302856, -0.29167240858078003, -0.7320956587791443, -0.08794010430574417, -0.07329623401165009, 0.819075882434845, -0.1364506185054779, 0.47427618503570557, -0.09988369792699814, 0.4609107971191406, 0.0313081331551075, 0.38659578561782837, -0.5398334264755249, -0.24901388585567474, 0.49062392115592957, 0.42303118109703064, 0.0202585868537426, 0.341665655374527, 0.17950986325740814, -0.2300575226545334, 0.07982219010591507, 0.22083112597465515, 0.24249793589115143, -0.7952530384063721, -0.28684332966804504, 0.2442762553691864, 0.35793185234069824, 0.02918531559407711, -0.24676728248596191, -0.8814140558242798, 0.9519125819206238, -0.00851026177406311, -0.013548646122217178, -0.0016059987246990204, 0.3899097442626953, 0.1636684238910675, -0.05433400720357895, 0.7923029661178589, 0.020372096449136734, -0.645415186882019, 0.12316929548978806, 0.11806942522525787, -0.6838461756706238, -0.2909466326236725, -0.1412140280008316, -0.36979857087135315, -0.03125262260437012, 0.12828728556632996, 0.6355857849121094, -0.12326247245073318, -0.27123233675956726, -0.885232150554657, -0.18666936457157135, 0.13704237341880798, -0.7149067521095276, -0.2790827751159668, 0.2641034722328186, 0.14474648237228394, -0.43770426511764526, -0.3751768469810486, -0.31852832436561584, -0.02812548168003559, 0.24527566134929657, 0.2980239987373352, 0.1857428252696991, 0.04205672815442085, 0.29928094148635864, 0.3771553635597229, 0.06672149896621704, -0.09400142729282379, 0.8971027135848999, -0.1794958859682083, -0.33167552947998047, 0.11852122843265533, 0.3580838739871979, 0.35573020577430725, -0.005152369383722544, 0.11931522190570831, 0.3095371723175049, 0.32036080956459045, -0.1252390444278717, -0.03754591569304466, 0.32857856154441833, -0.33555588126182556, -0.04601958021521568, 0.09732115268707275, -0.5489675998687744, -0.37129124999046326, -0.19275015592575073, -0.22636422514915466, -0.6016598343849182, -0.7873657941818237, 0.08493195474147797, -0.5818302631378174, 0.2769109308719635, -0.5206066370010376, -0.4048103392124176, 0.3663603961467743, 0.15727227926254272, -0.07070942968130112, -0.5799567103385925, 0.18410943448543549, -0.10740289092063904, -0.23841655254364014, 1.4005340337753296, -0.1753559559583664, 0.6592584252357483, -0.023432616144418716, -0.24421317875385284, 0.6842960715293884, -0.2708083391189575, -0.22950856387615204, 0.35724547505378723, 0.5085045099258423, 0.853561520576477, -0.1451370120048523, -0.18034227192401886, -0.0013792372774332762, 0.010004459880292416, 0.15545950829982758, 0.2473810762166977, 0.39274412393569946, -0.3068329691886902, -0.6914920806884766, -0.2550928294658661, -0.03359182924032211, -0.021787144243717194, -0.06823305040597916, -0.17778770625591278, -0.2394421398639679, -0.28648895025253296, -0.05325595661997795, -0.4443838596343994, 0.28869161009788513, -0.3221431374549866, -0.7509323954582214, 0.03571901470422745, -0.011071577668190002, 0.3515491187572479, 0.5242358446121216, -0.5264512300491333, 0.01412616390734911, 0.041156936436891556, 0.27823731303215027, -0.5612263083457947, -0.05710436776280403, -0.045995067805051804, 0.3987693786621094, 0.4213845133781433, -0.010774628259241581, 0.27633988857269287, 0.15059281885623932, -0.12592454254627228, -0.5519641637802124, -0.5195997953414917, 0.049816858023405075, -0.9983543157577515, 0.28226423263549805, -0.16964097321033478, 0.43239349126815796, -0.03418987989425659, 0.036261916160583496, 0.19875676929950714, -0.7743988037109375, -0.1230056956410408, -0.43659231066703796, -0.4990013837814331, 0.24728940427303314, 0.1605285257101059, 1.1813501119613647, 0.026001155376434326, 0.6021904945373535, -0.029246477410197258, -0.5923786163330078, -0.17736810445785522, 0.866748571395874, -0.4380061626434326, 1.5789514780044556, -0.2102491408586502, 0.015303368680179119, 0.47165316343307495, 0.5538949966430664, -0.10367089509963989, -0.7356749773025513, 0.20134495198726654, 0.6394962072372437, -0.5381616353988647, -0.7348979711532593, 0.0024319575168192387, -0.05141894146800041, -0.2698085904121399, 0.21009880304336548, 0.023088572546839714, 0.05382338538765907, -0.4721902906894684, -0.12058039009571075, -0.2185124158859253, 0.34151211380958557, -0.630149781703949, -0.07336452603340149, -0.1328173577785492, -0.4612143933773041, -0.06350371986627579, -0.3648250997066498, -0.6052151322364807, 0.5377383828163147, 1.2271648645401, -0.21773332357406616, 0.927538275718689, 0.2619924545288086, 0.04610705003142357, 0.374476820230484, 0.20182940363883972, 0.751097559928894, -0.21928027272224426, 0.05152874067425728, -0.05743846669793129, -0.11083553731441498, 0.2110617607831955, 0.13112790882587433, -0.09401532262563705, -0.2210041731595993, -0.4931428134441376, -0.008814152330160141, 0.565526008605957, -0.6260498762130737, -0.4485573470592499, -0.07793449610471725, -0.4337517321109772, -0.3840843439102173, 0.22171612083911896, -0.9146720170974731, 0.03954864665865898, 0.2923860549926758, 0.21240462362766266, 0.3038884103298187, -0.5665039420127869, 0.19110402464866638, 0.03310280293226242, 0.016333235427737236, -0.17011310160160065, -0.13645251095294952, -0.8936678767204285, -0.2801327407360077, -0.04498186707496643, 0.308761864900589, 0.4976138174533844, 0.09592856466770172, -0.03816606104373932, -0.47902020812034607, -0.08388820290565491, 1.0642502307891846, 0.8448920249938965, 0.6940014958381653, -0.5975243449211121, -1.1244417428970337, -0.15160764753818512, -0.08332198113203049, -0.5448824763298035, 0.2777819037437439, 0.6414121389389038, -0.30708369612693787, -0.6285198926925659, 0.088657908141613, 0.2378600537776947, 0.6475141644477844, -0.4795156717300415, -0.6674321889877319, 0.34546196460723877, -0.2590315639972687, -0.20201410353183746, -0.1771511435508728, -0.34441760182380676, -0.2832295596599579, 0.04457102715969086, -0.3059549629688263, 0.14298926293849945, 0.30279770493507385, -0.014073454774916172, -0.13663150370121002, 0.607240617275238, 1.0011570453643799, -0.14335572719573975, -0.0984857976436615, -0.27944958209991455, -0.45821425318717957, -0.00407586432993412, -0.08379625529050827, 0.12883181869983673, -0.42197781801223755, 0.46768486499786377, -5.656304359436035, -0.168286994099617, 0.13794247806072235, -0.2005874663591385, 0.4142196476459503, -0.11950740218162537, 0.9511327147483826, -0.33199939131736755, 0.06654410809278488, 0.1164873018860817, 0.31853070855140686, 0.1648910641670227, 0.053049392998218536, -0.22160428762435913, -0.27437224984169006, 0.0007403925992548466, 0.3121561110019684, -0.26538562774658203, 1.0640521049499512, 0.08346410095691681, 0.6534145474433899, -0.11088787764310837, -0.18052075803279877, 0.33975493907928467, 0.11054827272891998, -0.026785515248775482, -0.8540042042732239, 0.09830133616924286, -0.56309574842453, -0.5453490614891052, 0.135827898979187, -0.4119860827922821, 0.19096103310585022, 0.009890330955386162, 0.07841794937849045, -0.27706411480903625, 0.07725627720355988, 0.17526330053806305, -0.3455936312675476, -0.3107870817184448, 0.5109652280807495, 0.21071188151836395, -0.27582767605781555, 0.1149924024939537, 0.5670685172080994, 0.08392172306776047, -0.03955545648932457, -0.011170513927936554, -0.41934582591056824, 0.7326396703720093, 0.2633081376552582, -0.21226847171783447, 0.07256969809532166, 0.5693675875663757, 0.5326558351516724, 0.0628436878323555, -0.37709569931030273, 0.007857122458517551, -0.15070880949497223, -0.16876833140850067, -0.3024047911167145, 0.073917455971241, -0.3628050982952118, -0.24564650654792786, 0.013135047629475594, 0.21576561033725739, -0.4621126651763916, -0.5077388882637024, 0.45468610525131226, -0.40847158432006836, -0.2565893828868866, 0.2524435818195343, 0.3963150382041931, -0.6102600693702698, 0.5366898775100708, -0.4031282365322113, 0.11503399908542633, 0.015659280121326447, -0.3005290925502777, 0.30588260293006897, -0.49603408575057983, 0.19723521173000336, 0.35675621032714844, -0.13613761961460114, 0.2379162758588791, -0.18326950073242188, -0.48394453525543213, -0.07616347819566727, -0.3052254915237427, 0.5715263485908508, 0.29573580622673035, -0.6037980914115906, 0.5831509232521057, 0.8116257190704346, 0.032334715127944946, 0.41183122992515564, 0.5463352203369141, 0.868783175945282, 0.6067215204238892, 0.12318091094493866, 0.8493854403495789, 0.4983452260494232, -0.41988664865493774, -0.46963194012641907, -0.37269213795661926, 0.1136537566781044, -0.31380534172058105, 0.2454606592655182, 0.5498433113098145, -0.7642191648483276, 0.2214367836713791, 0.1425154060125351, -0.4001867175102234, -0.3306061923503876, 0.95445317029953, -0.1346278190612793, -0.516887903213501, -0.06341776251792908, 0.6456785798072815, -0.2973991632461548, 0.36865371465682983, 0.3936522305011749, -0.7426830530166626, 0.20586486160755157, 0.13828328251838684, 0.09307581186294556, -0.01248359028249979, 0.5963243246078491, -0.476327121257782, 0.05410383641719818, 0.46124643087387085, 0.1923467069864273, -0.28922736644744873, -0.3015361726284027, 0.5115846395492554, -0.5545802712440491, -0.3808213472366333, 0.7575219869613647, 0.24416150152683258, 0.2605299949645996, 0.11525429785251617, -0.274040162563324, -0.07442086189985275, -0.09094814211130142, 0.4222792387008667, 0.12337416410446167, -0.060029901564121246, 0.18645864725112915, -0.2935347557067871, -0.2299014776945114, -0.09475447237491608, -0.09587521106004715, 0.23784390091896057, -0.2790238857269287, 0.1466207355260849, -0.1613137274980545, 0.3083559274673462, 0.4417043626308441, 0.3694847822189331, -0.7457578778266907, 0.07150336354970932, 0.118553526699543, -1.1431647539138794, 0.033922191709280014, -0.8910503387451172, -0.21408672630786896, -0.34561437368392944, -0.2936462461948395, -0.23439280688762665, 0.22859695553779602, -0.6150596737861633, -0.09169891476631165, -0.17370589077472687, -0.13294881582260132, 0.5367147326469421, -0.4753327965736389, -0.25360551476478577, 0.07520467787981033, -0.2073521763086319, -0.41357818245887756, -0.22905346751213074, -0.6114140748977661, -0.062207043170928955, 0.05654878169298172, 0.27445390820503235, 0.032458581030368805, -0.1460244208574295, -0.2017672210931778, 0.07142109423875809, -0.5106486082077026, -0.184425488114357, -0.2206363081932068, 0.08961645513772964, -0.3808198571205139, 0.17405445873737335, -0.18584056198596954, 0.15314052999019623, 0.2296963930130005, 0.12264422327280045, -0.6305955052375793, 0.3249163031578064, 0.4709247648715973, -0.16244858503341675, 0.17574599385261536, 0.4479482173919678, 0.16788429021835327, -0.36181387305259705, 0.3835398256778717, -0.24057969450950623, -0.15827086567878723, 0.17304165661334991, -0.42938467860221863, -0.043918974697589874, 0.404002845287323, -0.16993436217308044, -0.10086667537689209, 0.6431072354316711, -0.05501915141940117, -0.18222369253635406, 0.2862076163291931, 0.5515227317810059, -0.47932204604148865, 0.012180561199784279, 0.00743055110797286, -0.6113999485969543, 0.24953436851501465, 0.30216172337532043, -1.0420925617218018, 0.47337087988853455, -0.14904586970806122, 0.01009610015898943, -0.31876668334007263, -0.02442830428481102, 0.031302087008953094, 0.009947155602276325, -0.2870837450027466, -0.5611962080001831, 0.4536561965942383, -0.25389978289604187, 0.6246808767318726, -0.0405547097325325, 0.5954956412315369, -0.17279264330863953, -0.5277009606361389, -0.17690308392047882, 0.5066707730293274, 0.5487058758735657, -0.5720473527908325, -0.35506656765937805, 0.234675794839859, 0.6096080541610718, -0.33718010783195496, 0.02227073162794113, 0.5331295728683472, 1.232079029083252, 0.02520538680255413, -0.0891844779253006, -0.659206748008728, -0.5432224273681641, 0.31033647060394287, -0.293222039937973, 0.32938313484191895, -0.27923235297203064, 0.4644588828086853, 0.38621586561203003, -0.23064950108528137, -0.08586717396974564, -0.5481745600700378, 0.4887610673904419, -0.12376783788204193, -0.6188547015190125, -0.06769128888845444, 0.5266469717025757, 0.545315682888031, -0.39505311846733093, 0.5480064749717712, -0.2676216959953308, -0.034983523190021515, 0.2098764330148697, 0.042834535241127014, -0.4092497229576111, -0.6591044068336487, 0.5001394152641296, -0.5390256643295288, 0.3643641471862793, -0.7960585355758667, 0.06239468231797218, -0.5035302639007568, -0.07343672960996628, -0.16235004365444183, -0.42474186420440674, 0.1447066366672516, -0.7720972895622253, -0.3067968189716339, 0.12328934669494629, 0.07214389741420746, -0.14120031893253326, -0.23487697541713715, -0.05283500254154205, 0.18410292267799377, -0.2702158987522125, 0.07530268281698227, 0.5439453721046448, 0.12680871784687042, -0.06282370537519455, 0.20346316695213318, 0.20133814215660095, 0.045720625668764114, -0.6488760709762573, -0.24541036784648895, 0.1427765190601349, -0.007128737401217222, 0.4809456467628479, -0.2119806557893753, -0.2325640767812729, 0.0915517508983612, -0.17202767729759216, 0.3364558815956116, 0.04943060502409935, 0.4280303716659546, 0.2179102897644043, 0.41118595004081726, 0.6697206497192383, -0.11725302785634995, -0.06640253961086273, 0.14758679270744324, 0.438450425863266, -0.04137694835662842, 0.20004476606845856, 0.38163894414901733, 0.23537331819534302, 0.22242535650730133, -0.17431512475013733, 1.0782400369644165, 0.38917937874794006, 0.08106222003698349, -0.2049536108970642, -0.485005259513855, -0.23338682949543, -0.534647524356842, 0.8461492657661438, -0.05422971770167351, -0.32349085807800293, -0.0681283175945282, 0.526603639125824, 0.35018524527549744, 0.019413065165281296, -0.26375845074653625, -0.2642016112804413, 0.6333489418029785, 0.2158619612455368, -0.09285392612218857, -0.8438078165054321, 0.031539179384708405, -0.739602267742157, 0.5854206681251526, 0.8925536274909973, -0.3082820475101471, -0.3098461627960205, 0.32582154870033264, -0.44698604941368103, -0.011317426338791847, -0.05088265240192413, 1.1159816980361938, -0.0432792603969574, 0.0045969123020768166, 0.05904140695929527, 0.017996080219745636, 0.32927820086479187, -0.04108678922057152, 0.13155029714107513, 0.09564471989870071, -0.03108617663383484, 0.43046891689300537, 0.5163716077804565, -0.29927462339401245, 0.13357822597026825, -0.3329980969429016, 0.2989787459373474, 0.6110029220581055, -0.5444731116294861, 0.3167044222354889, -0.10931556671857834, -0.6389589309692383, -0.5088131427764893, -0.2863532304763794, -0.29682105779647827, -0.2089347094297409, -0.20880699157714844, 0.06002211198210716, 0.39630821347236633, -0.5722691416740417, 0.32962411642074585, 0.07573432475328445, 0.047893136739730835, -0.005538345314562321, 0.014345264062285423, 0.041466012597084045, 0.16226604580879211, 0.5203097462654114, 0.09904318302869797, 0.43298354744911194, -0.1708030253648758, 0.625533938407898, -0.4501632750034332, 0.6918461322784424, -0.6143009066581726, -0.33215296268463135, -0.4562373161315918, -0.16453060507774353, 1.0951071977615356, 0.8560823202133179, -0.3178520202636719, 0.2480379343032837, 0.09043242782354355, 0.34902969002723694, 0.25957635045051575, -0.6193585395812988, -0.1339438110589981, -0.5513497591018677, -0.0007376481662504375, -0.38855937123298645, 0.7023829221725464, 0.18649108707904816, -0.689262866973877, 0.15727363526821136, 0.27352291345596313, 0.44150620698928833, -0.1287059336900711, 0.23141734302043915, -0.2802395820617676, 0.09809411317110062, -0.6773914694786072, 0.17630067467689514, -0.39656636118888855, 0.2546250820159912, -0.5816977024078369, -0.05066138133406639, -0.20486801862716675, -0.5280136466026306, 0.15530197322368622, -0.24483931064605713, 0.0032155567314475775, -0.27650249004364014, -0.09160611033439636, -0.1219957023859024, -0.1595604121685028, -0.9319080710411072, -0.36921215057373047, 0.4102949798107147, 0.5486322641372681, -0.5406699180603027, -0.36387982964515686, 0.4722861647605896, 0.15989121794700623, -0.3454528748989105, -0.04900823161005974, -0.13948754966259003, 0.2965160310268402, 0.09621333330869675 ]
All eukaryotes have three nuclear DNA-dependent RNA polymerases, namely, Pol I, II, and III. Interestingly, plants have catalytic subunits for a fourth nuclear polymerase, Pol IV. Genetic and biochemical evidence indicates that Pol IV does not functionally overlap with Pol I, II, or III and is nonessential for viability. However, disruption of the Pol IV catalytic subunit genes NRPD1 or NRPD2 inhibits heterochromatin association into chromocenters, coincident with losses in cytosine methylation at pericentromeric 5S gene clusters and AtSN1 retroelements. Loss of CG, CNG, and CNN methylation in Pol IV mutants implicates a partnership between Pol IV and the methyltransferase responsible for RNA-directed de novo methylation. Consistent with this hypothesis, 5S gene and AtSN1 siRNAs are essentially eliminated in Pol IV mutants. The data suggest that Pol IV helps produce siRNAs that target de novo cytosine methylation events required for facultative heterochromatin formation and higher-order heterochromatin associations.
[ 0.01030326820909977, 0.014785992912948132, -0.013355216011404991, 0.013740090653300285, 0.002538320142775774, 0.003720372449606657, 0.009236428886651993, 0.007634990382939577, -0.01214020699262619, -0.01563270576298237, -0.009305840358138084, 0.002226320095360279, -0.012220703065395355, 0.014803077094256878, 0.00133410282433033, 0.0086593609303236, -0.013959343545138836, -0.007003105245530605, 0.008795272558927536, -0.005644776858389378, -0.006980312988162041, 0.019619401544332504, 0.008755850605666637, 0.0064345235005021095, -0.02408153936266899, -0.024838972836732864, 0.025797711685299873, 0.0011666615027934313, 0.0027058336418122053, 0.015031272545456886, 0.00995153933763504, -0.009502682834863663, 0.01973106525838375, 0.011748947203159332, -0.009426014497876167, 0.007649997249245644, -0.001030017388984561, 0.013037675991654396, 0.021040933206677437, -0.004348465241491795, -0.015184838324785233, -0.011708670295774937, -0.001711769960820675, 0.007418381050229073, -0.008010582998394966, -0.007171861827373505, -0.005055341869592667, 0.02667281962931156, -0.014000775292515755, 0.005627490114420652, -0.015644479542970657, 0.005561236757785082, -0.026475980877876282, -0.0003090132959187031, -0.005291531328111887, -0.027866436168551445, 0.01685674488544464, -0.007706685923039913, -0.011295586824417114, 0.008618448860943317, -0.01068853959441185, 0.021527010947465897, 0.0018733044853433967, 0.005787128582596779, -0.011561274528503418, -0.06704095005989075, -0.00594842154532671, 0.00925901997834444, -0.02246127650141716, 0.009228609502315521, -0.018917221575975418, 0.0127607062458992, -0.014482573606073856, 0.009106281213462353, 0.010212944820523262, 0.03024004027247429, -0.013863565400242805, 0.012282261624932289, 0.019460175186395645, -0.0050593093037605286, 0.006114717107266188, -0.012166710570454597, -0.005324413999915123, 0.013173616491258144, 0.004160373471677303, 0.015964068472385406, -0.02231469191610813, 0.015841908752918243, 0.011995945125818253, -0.02611463889479637, 0.02215266413986683, 0.0017354427836835384, -0.008686888962984085, 0.012545447796583176, 0.004623250104486942, 0.016522862017154694, -0.031113823875784874, 0.0014761234633624554, -0.025166131556034088, -0.012770207598805428, -0.013550431467592716, 0.021655255928635597, 0.015058286488056183, -0.0030800201930105686, -0.010426092892885208, 0.011296981945633888, -0.0077307564206421375, -0.010016489773988724, 0.03433549776673317, 0.005399556830525398, 0.011498701758682728, 0.023318229243159294, 0.00697175320237875, 0.001679989043623209, -0.0034993458539247513, 0.004063501954078674, -0.011697417125105858, -0.012628900818526745, 0.009005086496472359, 0.007136199623346329, -0.0017236986896023154, -0.00040861964225769043, -0.011249423027038574, 0.004708543885499239, 0.006695690099149942, -0.012900121510028839, 0.0015016510151326656, -0.00895860604941845, 0.018523182719945908, 0.010476917028427124, -0.006640993058681488, 0.023826967924833298, -0.022636715322732925, -0.0011238199658691883, -0.0026608705520629883, -0.005993935279548168, 0.012921798974275589, 0.002609871095046401, -0.004368296824395657, -0.025932956486940384, -0.021401207894086838, 0.00735725462436676, 0.00852909591048956, 0.006022128742188215, 0.015464435331523418, 0.0052316016517579556, -0.017356030642986298, -0.0027992590330541134, 0.004221143200993538, -0.011050564236938953, 0.007963955402374268, -0.0205666683614254, -0.00039953505620360374, -0.018343225121498108, 0.04822777956724167, -0.004493470303714275, -0.023647550493478775, 0.0099977757781744, 0.003151567652821541, 0.0001664683222770691, 0.0029439739882946014, -0.006557789631187916, 0.0055549731478095055, 0.010282543487846851, 0.024311987683176994, -0.0001700427383184433, -0.01023297943174839, -0.01170935295522213, -0.0031679263338446617, 0.004221872892230749, -0.004001154564321041, -0.004341318737715483, 0.023855110630393028, 0.0033286591060459614, -0.0031680413521826267, -0.009137211367487907, 0.0061541032046079636, 0.005025013349950314, -0.02297453209757805, 0.06658722460269928, -0.00008990417700260878, 0.03547452390193939, 0.006029471289366484, 0.018065456300973892, 0.0031893840059638023, -0.009978918358683586, -0.011650903150439262, 0.0017849073046818376, -0.00136539526283741, -0.027661990374326706, 0.006674190983176231, 0.029083292931318283, -0.0031993044540286064, 0.01759517565369606, -0.013167031109333038, 0.003040577284991741, -0.012920758686959743, 0.008290071040391922, 0.005550604313611984, 0.010037505067884922, -0.01046046707779169, -0.015088784508407116, 0.014062821865081787, -0.009527110494673252, -0.01965654455125332, 0.006509811617434025, 0.0028647934086620808, 0.007831967435777187, -0.028716599568724632, 0.02867262437939644, 0.024214601144194603, -0.015297168865799904, -0.01305382139980793, -0.009052515961229801, 0.014790070243179798, 0.005264428444206715, 0.015313452109694481, -0.0058897715061903, -0.013262959197163582, -0.013944711536169052, 0.00020910659804940224, -0.015150027349591255, -0.0037963874638080597, -0.0077918460592627525, 0.012142837047576904, -0.015853237360715866, 0.01564558781683445, 0.007148834876716137, -0.0028679710812866688, -0.0008628536015748978, -0.0014804122038185596, -0.017423078417778015, -0.013330780901014805, -0.00901629775762558, -0.020371975377202034, 0.0026653925888240337, 0.0113966204226017, -0.006062436383217573, 0.010479912161827087, -0.0034662471152842045, -0.01904582977294922, -0.003010474145412445, 0.025629278272390366, -0.030759239569306374, 0.009038839489221573, -0.016107972711324692, -0.006852644495666027, 0.020536167547106743, 0.07292263209819794, -0.010764864273369312, 0.005278292577713728, 0.004660419188439846, -0.0004568789154291153, -0.038292087614536285, -0.01321108266711235, -0.0043763453140854836, 0.015790430828928947, 0.0012503508478403091, 0.024461744353175163, 0.007223951630294323, 0.0059446729719638824, 0.003063696902245283, -0.01898837834596634, -0.016008656471967697, -0.02546667493879795, -0.006969112437218428, 0.01456847507506609, -0.010751768946647644, 0.013435505330562592, -0.01797732152044773, 0.009278284385800362, -0.002896183170378208, 0.0023257059510797262, -0.0817079171538353, -0.00490475632250309, 0.02190428413450718, -0.005068762227892876, -0.001244387007318437, -0.0038141184486448765, 0.008408229798078537, 0.012962667271494865, -0.004222363233566284, -0.012141291983425617, 0.01561201736330986, 0.0009288862347602844, -0.01124786026775837, -0.0003722796682268381, 0.006038203835487366, -0.004778747446835041, 0.008141247555613518, -0.007915745489299297, -0.04313281551003456, -0.0223601795732975, -0.022740693762898445, -0.0054712239652872086, -0.011897928081452847, 0.01836155727505684, -0.017912063747644424, 0.03517961502075195, 0.016093088313937187, 0.01618354022502899, 0.0007024230435490608, 0.0008408722933381796, -0.017636021599173546, -0.005998918786644936, -0.0020609465427696705, -0.0017486438155174255, 0.03898719325661659, 0.0369202084839344, -0.0061061023734509945, 0.0022824450861662626, -0.002525131683796644, 0.027492936700582504, -0.0013954025926068425, 0.005369401536881924, -0.00035084038972854614, 0.0015605217777192593, 0.007039851974695921, 0.0026984019204974174, -0.0019488264806568623, 0.02137960121035576, 0.01705995202064514, 0.006945622619241476, 0.013954101130366325, 0.0005071080522611737, -0.0053208693861961365, 0.018379682675004005, -0.006032765377312899, 0.008908362127840519, 0.0010388483060523868, 0.008022600784897804, -0.013569006696343422, -0.002994283102452755, -0.0034727510064840317, 0.003046172671020031, -0.005359498783946037, 0.006066519301384687, -0.006637088023126125, 0.018063295632600784, 0.012633804231882095, 0.009113848209381104, -0.015083562582731247, 0.012608466669917107, 0.016260189935564995, -0.012158879078924656, 0.011756354942917824, -0.013281339779496193, -0.02724844217300415, -0.015180028043687344, -0.006556497886776924, -0.017124537378549576, -0.0055926344357430935, -0.0016094651073217392, -0.012482213787734509, 0.0007089807186275721, 0.006801021751016378, -0.021615171805024147, -0.02397463284432888, 0.009004753082990646, 0.004383946303278208, -0.009002724662423134, 0.010709268972277641, -0.014380766078829765, 0.011099612340331078, -0.011855961754918098, 0.009555313736200333, 0.01512720063328743, -0.006865257862955332, -0.013445733115077019, 0.009209898300468922, 0.0036315834149718285, 0.01713503897190094, 0.0068305437453091145, -0.008515952154994011, 0.005265660583972931, 0.009291766211390495, -0.00033966475166380405, -0.04155701398849487, 0.006650461815297604, -0.0036953475791960955, 0.010955354198813438, -0.010294301435351372, 0.0017885550623759627, 0.002321310108527541, -0.01499017234891653, -0.0055197449401021, 0.034360289573669434, 0.0025371485389769077, 0.002531731966882944, 0.003308702725917101, 0.0050167785957455635, 0.07249222695827484, 0.0138895558193326, 0.004282488953322172, -0.013768317177891731, -0.008646908216178417, 0.00013492442667484283, -0.036453839391469955, 0.00773854274302721, -0.02985190786421299, -0.013580413535237312, 0.011966342106461525, -0.010467279702425003, -0.011723323725163937, 0.0035359826870262623, -0.008914301171898842, -0.0008986964821815491, -0.036095935851335526, -0.009809572249650955, -0.002091627102345228, 0.014504746533930302, -0.00842726044356823, -0.0010336204431951046, -0.008942192420363426, -0.024919617921113968, 0.003221169114112854, -0.017105983570218086, 0.025317244231700897, -0.012868538498878479, -0.026354551315307617, 0.008136053569614887, 0.016849415376782417, 0.025026023387908936, -0.008388645015656948, 0.011372135952115059, 0.023264586925506592, 0.01681140437722206, 0.010046602226793766, 0.011020450852811337, -0.025379303842782974, -0.006720618810504675, -0.00881913397461176, -0.0026364850345999002, 0.00011645769700407982, 0.0003343851421959698, 0.0033084996975958347, -0.010105207562446594, 0.02053317055106163, -0.006713515613228083, -0.0072435662150382996, -0.002407223917543888, -0.012270588427782059, 0.002345232293009758, 0.01107134111225605, 0.01080046035349369, -0.02034703642129898, -0.016659047454595566, 0.021008744835853577, -0.01726399175822735, -0.013214980252087116, 0.01400004606693983, -0.024227749556303024, -0.03354952484369278, 0.03694956749677658, -0.007396767847239971, 0.00006782007403671741, -0.017584439367055893, 0.0004413181450217962, -0.0020746137015521526, 0.002723922021687031, 0.0036305319517850876, 0.0038714318070560694, -0.005388777237385511, -0.016904979944229126, 0.0023472029715776443, -0.004303534049540758, 0.009683370590209961, -0.0067681679502129555, -0.01606769859790802, 0.032093219459056854, -0.009177863597869873, -0.004295109771192074, 0.041947007179260254, -0.03878381475806236, -0.011630152352154255, -0.010948985815048218, -0.015063682571053505, -0.01937553659081459, -0.07534394413232803, -0.026085620746016502, -0.014592431485652924, -0.004579081200063229, -0.016211334615945816, 0.01786242052912712, -0.02000112645328045, -0.015898339450359344, -0.006209518760442734, -0.011491457000374794, 0.02113508991897106, 0.002559075364843011, 0.012359270825982094, 0.0026550181210041046, 0.010111438110470772, 0.014575688168406487, 0.026797665283083916, 0.007699977606534958, 0.0018844595178961754, 0.010691440664231777, 0.007913230918347836, 0.0024625584483146667, -0.024227427318692207, -0.004560221452265978, -0.020965907722711563, -0.081575408577919, -0.03345612809062004, 0.0195423886179924, -0.004439624957740307, -0.019012615084648132, -0.0017810151912271976, -0.0011901103425770998, -0.008481788448989391, -0.014538622461259365, -0.01336635835468769, -0.01922743208706379, -0.00047452538274228573, 0.007716630585491657, 0.008092266507446766, -0.015432536602020264, -0.00483284704387188, 0.025742363184690475, -0.0032917968928813934, -0.026665640994906425, -0.002490363549441099, -0.018189439550042152, -0.00360290240496397, -0.010324513539671898, 0.009615626186132431, 0.001477502752095461, -0.027028586715459824, -0.02742536924779415, 0.010715935379266739, -0.0055898334830999374, -0.017517661675810814, -0.03199710696935654, -0.00448877876624465, -0.012312576174736023, -0.01034415140748024, 0.0076577551662921906, -0.02684071473777294, 0.005697900895029306, -0.01437219325453043, 0.00874951109290123, -0.01899702101945877, 0.0007558098877780139, 0.004641047213226557, -0.011684145778417587, 0.012871356680989265, -0.014606891199946404, -0.008125575259327888, 0.004434649366885424, -0.010472248308360577, 0.004073236137628555, -0.012387982569634914, 0.01248694583773613, 0.007309863343834877, 0.00696762278676033, 0.006345505826175213, 0.01903999224305153, 0.004561536479741335, 0.0006270420271903276, 0.013670790940523148, 0.0050860061310231686, 0.00736582325771451, 0.013798613101243973, -0.00490269809961319, 0.008341319859027863, 0.07169004529714584, -0.027302222326397896, 0.0063746292144060135, -0.04521861672401428, -0.011144046671688557, 0.0008396717021241784, 0.020812520757317543, -0.010153289884328842, -0.0035674162209033966, -0.030156362801790237, -0.03611762821674347, -0.003537870245054364, 0.007955663837492466, 0.015680745244026184, 0.010752161033451557, -0.012492470443248749, 0.0006161262281239033, 0.027612900361418724, 0.011804701760411263, -0.01119192410260439, -0.00775716919451952, 0.008475066162645817, -0.003963475115597248, -0.017012594267725945, -0.004180191550403833, 0.000685793231241405, 0.009105566889047623, 0.01892900839447975, -0.0003183868248015642, 0.019697604700922966, -0.004532093182206154, -0.008113309741020203, 0.005575533024966717, -0.005382167175412178, 0.011578730307519436, 0.020623978227376938, 0.00196932558901608, 0.01120777241885662, -0.011150680482387543, 0.0012470379006117582, -0.03176965191960335, -0.005487318150699139, 0.0013815179700031877, -0.016938146203756332, 0.0024626138620078564, 0.020900536328554153, 0.003925973083823919, 0.007391320541501045, -0.021762169897556305, 0.0007816711440682411, 0.019174080342054367, 0.000414485577493906, 0.0357830710709095, -0.004317054059356451, -0.0016727035399526358, 0.004384210798889399, -0.0068996138870716095, 0.012228498235344887, 0.00528061855584383, -0.0021618453320115805, 0.0004378361627459526, -0.0007641457486897707, -0.005510597489774227, -0.01221076026558876, 0.0021748559083789587, -0.01673196814954281, 0.012251565232872963, -0.016472434625029564, -0.005310004577040672, 0.009903599508106709, -0.032177865505218506, -0.010427912697196007, 0.0026079262606799603, 0.032324910163879395, 0.017224855720996857, -0.006799690425395966, 0.011698446236550808, 0.006385908927768469, 0.02581513673067093, 0.0036157690919935703, -0.019287273287773132, -0.01679805852472782, 0.033073462545871735, 0.008185390383005142, -0.008327544666826725, -0.005028469488024712, 0.01719815656542778, 0.021207062527537346, -0.0023233199026435614, 0.010733986273407936, 0.028251828625798225, -0.004805100616067648, 0.003093116683885455, 0.014496237970888615, 0.00203616451472044, 0.03432150185108185, 0.008735689334571362, 0.009754739701747894, -0.009926959872245789, -0.013517245650291443, 0.017715301364660263, -0.006725753657519817, -0.009473580867052078, 0.007703481242060661, 0.015401452779769897, 0.010523559525609016, -0.012099893763661385, -0.000021105632185935974, 0.004296396858990192, 0.012413782998919487, 0.02020246535539627, -0.02277519926428795, 0.0009273272007703781, -0.00041634682565927505, 0.015069734305143356, 0.022413048893213272, -0.022575154900550842, -0.006892784032970667, 0.013539371080696583, -0.013746514916419983, -0.025699764490127563, 0.0015670275315642357, -0.033762700855731964, 0.013797746039927006, -0.013940796256065369, -0.010913094505667686, -0.007923716679215431, 0.027314607053995132, 0.00418287655338645, -0.006101604551076889, 0.03026430681347847, -0.004242574330419302, -0.010624364949762821, -0.02753005176782608, -0.017721395939588547, -0.011506063863635063, -0.009889353066682816, 0.0060971807688474655, 0.017612459138035774, -0.014090603217482567, 0.0021938898134976625, -0.016727441921830177, -0.0009165304945781827, 0.0027794986963272095, 0.010138217359781265, -0.00022988475393503904, 0.013286019675433636, 0.007820526137948036, 0.0024025249294936657, 0.010602358728647232, 0.019782422110438347, -0.009494885802268982, -0.0021336153149604797, -0.005160178989171982, 0.00393150607123971, 0.014529255218803883, -0.01243127416819334, -0.02254246175289154, -0.0009663056116551161, -0.020192530006170273, 0.008262070827186108, 0.030727917328476906, -0.0062948353588581085, -0.006754057481884956, -0.01839018240571022, -0.023602603003382683, 0.020436469465494156, 0.007445762399584055, -0.01776701770722866, 0.004065821412950754, 0.021405160427093506, -0.008588936179876328, 0.009979580529034138, 0.0047027235850691795, -0.014108089730143547, 0.0006581719499081373, -0.01130819134414196, -0.005236733704805374, 0.010647330433130264, 0.00587443495169282, 0.010243863798677921, -0.016777915880084038, 0.003442324697971344, -0.0029773679561913013, 0.021763835102319717, -0.007580810226500034, -0.0016599674709141254, 0.00965878739953041, -0.004179710987955332, 0.02067059651017189, -0.019255153834819794, 0.023826241493225098, -0.011507359333336353, -0.008376060053706169, -0.011550650000572205, -0.015026317909359932, 0.003751604352146387, -0.017740193754434586, 0.018335817381739616, 0.007451406680047512, 0.0015738247893750668, 0.0015132594853639603 ]
[ 0.27398034930229187, 0.06237148866057396, 0.22448322176933289, -0.1047649160027504, -0.15340349078178406, -0.3177080452442169, 0.18593408167362213, 0.04849785938858986, -0.09223771840333939, -0.26602959632873535, 0.2450718730688095, -0.20956376194953918, -0.8711299300193787, 0.2349558025598526, 0.1311430186033249, 0.7056221961975098, 0.31230464577674866, 0.9008572697639465, 0.16110384464263916, -0.6323515176773071, -0.09162414819002151, 0.23729227483272552, 1.0552024841308594, 0.21990130841732025, 0.5910528302192688, -0.09895049035549164, 0.5050277709960938, -0.1549377590417862, 0.40118688344955444, 0.05449885502457619, -0.37044697999954224, 0.3945271074771881, 0.40606215596199036, 0.43231770396232605, 0.09340143948793411, -0.4961276352405548, -0.7810163497924805, 0.1501435786485672, 0.30803143978118896, 0.04259099066257477, -0.17958970367908478, -0.5805139541625977, 0.09570367634296417, 0.5520926117897034, -0.31744933128356934, -0.09597029536962509, -1.1565380096435547, 1.189988374710083, -0.3665437400341034, 0.4275871217250824, -0.2513391375541687, 0.04457378014922142, 0.41664209961891174, 0.2864478826522827, 0.518703818321228, -0.10012394934892654, -0.6020733714103699, 0.24256858229637146, 0.41265493631362915, -0.5039117336273193, -0.006315314676612616, 0.13685904443264008, -0.7188648581504822, 0.23074577748775482, 0.6667434573173523, 0.4507491886615753, -0.011009251698851585, -0.48820480704307556, -1.0583972930908203, 0.008356434293091297, 0.16581018269062042, -0.6099622249603271, 0.09995091706514359, 0.18020270764827728, -0.030347460880875587, -0.7445071339607239, -0.36645352840423584, -0.03352602943778038, 0.2559907138347626, -0.23445811867713928, -0.020548343658447266, -0.05042518302798271, -0.08535325527191162, 0.3364507853984833, 0.2968747913837433, -0.04907925799489021, -0.47572648525238037, 0.36980435252189636, -0.6694992780685425, -0.37271320819854736, 0.010481847450137138, 0.007533129304647446, 0.35538166761398315, 0.18581624329090118, 0.09315712749958038, 0.341396689414978, -0.1514868587255478, -0.08980702608823776, -0.34276506304740906, 0.2959851920604706, -0.5169335007667542, 0.13614998757839203, 0.05489940568804741, -0.5275276303291321, -0.5080908536911011, -0.5155132412910461, 0.007629114668816328, -0.560907781124115, -0.37293460965156555, 0.12341006100177765, -0.27555641531944275, 0.022547511383891106, -0.2583257257938385, -0.2804369628429413, 0.10085247457027435, 0.22577811777591705, 0.07839680463075638, -0.6549220085144043, 0.21993069350719452, -0.014264524914324284, -0.16460882127285004, 1.0661288499832153, -0.03583196550607681, 0.5258132219314575, -0.04153500124812126, -0.28287479281425476, -0.08501817286014557, -0.12403585761785507, -0.5410829186439514, -0.16503433883190155, 0.52773118019104, 1.4177803993225098, -0.33548563718795776, 0.14542768895626068, -0.1293451339006424, -0.1544457972049713, -0.015953583642840385, 0.1948387324810028, 0.5166807174682617, -0.01339031383395195, -0.6941469311714172, -0.23089683055877686, 0.22705325484275818, 0.02074706368148327, -0.13598203659057617, -0.5474736094474792, -0.11036718636751175, -0.16574575006961823, -0.33606070280075073, -0.47983986139297485, -0.11338070034980774, -0.23957370221614838, -0.6981916427612305, -0.22981835901737213, 0.1653735190629959, 0.14203177392482758, 0.2934781014919281, 0.14244306087493896, 0.14470839500427246, 0.09419550746679306, -0.16790582239627838, -0.473866730928421, -0.04426709935069084, -0.19539372622966766, 0.7545939683914185, -0.3277641832828522, 0.4505947232246399, 0.4014863967895508, 0.03200149163603783, 0.06553199887275696, -0.13140244781970978, -0.2816615104675293, 0.15089835226535797, -0.5069841146469116, -0.29196956753730774, -0.70099276304245, 0.22370211780071259, -0.2912713885307312, 0.18028946220874786, -0.17786464095115662, -0.6094824075698853, -0.19697344303131104, -0.1952447146177292, -0.42371252179145813, 0.5314159989356995, 0.3431938588619232, 0.40062981843948364, 0.06631968170404434, 0.26950952410697937, 0.20337679982185364, 0.2299930900335312, -0.39991438388824463, 0.224258154630661, -0.39107653498649597, 1.1073106527328491, -0.19971784949302673, -0.0070111979730427265, 0.9902654886245728, 0.2795630693435669, -0.11587115377187729, -0.4670979976654053, 0.21279805898666382, 0.46295320987701416, -0.8054851293563843, -0.4017663896083832, 0.5920618176460266, -0.041417527943849564, -0.4588494300842285, 0.4749464690685272, -0.21620188653469086, 0.11951963603496552, -0.14724233746528625, 0.3451753854751587, 0.013014430180191994, 0.128580704331398, -0.6795750856399536, -0.3373219966888428, -0.20051568746566772, -0.4728867709636688, 0.04642925411462784, 0.24834953248500824, -0.4033673405647278, 0.6338899731636047, 0.6702902317047119, -0.17436346411705017, 0.5001819729804993, 0.5953959822654724, 0.2511327266693115, 0.7284848093986511, 0.2091131955385208, 0.5890359282493591, -0.8330928683280945, 0.10735400021076202, 0.12648315727710724, 0.14173226058483124, 0.28648969531059265, -0.23015433549880981, 0.15496426820755005, -0.20476742088794708, -0.04992268607020378, -0.05476665124297142, 0.5100482702255249, -1.1034715175628662, -0.4963645935058594, 0.08535270392894745, -0.4761740267276764, 0.04467237368226051, 0.18397685885429382, -0.5843484997749329, 0.1250380426645279, 0.07167418301105499, -0.03097403235733509, 0.4831060767173767, -0.6570284366607666, -0.06060886010527611, 0.05259375274181366, 0.06823538988828659, -0.036428358405828476, 0.2874758541584015, -0.6007662415504456, -0.676344096660614, -0.5124561190605164, -0.37002089619636536, -0.49162015318870544, -0.17264297604560852, -0.07416824996471405, -0.7606036067008972, -0.2905242145061493, 1.3530447483062744, 0.7570369243621826, 0.7597752809524536, -0.10784443467855453, -0.7535266280174255, -0.15025095641613007, -0.04414089769124985, -0.8170406818389893, 0.42210379242897034, 0.41298073530197144, -0.1758861243724823, -0.24807164072990417, -0.23229336738586426, 0.29218217730522156, 0.5655558109283447, -0.7005720138549805, -0.5044278502464294, 0.277640163898468, 0.19252462685108185, -0.2502036392688751, -0.03695523738861084, -0.6435390114784241, -0.39803779125213623, 0.03120948001742363, -0.24531106650829315, -0.29416635632514954, 0.17050351202487946, 0.06545858830213547, -0.16371454298496246, 0.16374526917934418, 0.5580825209617615, -0.2909338176250458, -0.1051558256149292, -0.11076764017343521, -0.020752811804413795, 0.03363348916172981, 0.33115801215171814, 0.29456737637519836, 0.08072774857282639, 0.34814441204071045, -5.75073766708374, -0.061404626816511154, -0.20339933037757874, -0.39042365550994873, 0.3287885785102844, -0.14021727442741394, 0.99210125207901, 0.33551865816116333, 0.2674059569835663, -0.10529843717813492, -0.10958684980869293, 0.034651655703783035, -0.06681893765926361, 0.14348967373371124, 0.20821937918663025, 0.13505713641643524, 0.4660364091396332, -0.15680180490016937, 0.6067532300949097, -0.0724337249994278, 0.37900102138519287, -0.10017357766628265, 0.1744212806224823, 0.23570208251476288, -0.01310367975383997, -0.2723773717880249, -0.537460207939148, -0.14796356856822968, -0.0450718067586422, -0.8925891518592834, -0.3562775254249573, -0.5878030061721802, -0.266538143157959, -0.649782657623291, 0.2954317033290863, -0.10460767149925232, -0.24537748098373413, 0.538836658000946, -0.06706340610980988, 0.2973080575466156, 0.648269772529602, -0.11102212965488434, 0.14572860300540924, 0.012855229899287224, 0.097235769033432, 0.19630783796310425, -0.16577430069446564, -0.19107964634895325, -0.28368353843688965, 0.9559857249259949, -0.41191044449806213, 0.027957944199442863, 0.9741050004959106, 0.06430906802415848, 0.724994957447052, -0.12741711735725403, -0.09027811139822006, 0.39556995034217834, -0.0998438149690628, -0.5104181170463562, -0.1570012867450714, -0.09296367317438126, -0.08345995098352432, -0.3463001549243927, 0.04239407554268837, 0.11071106791496277, -0.6532319188117981, -0.3569873571395874, 0.5565603971481323, 0.038297854363918304, -0.5455645322799683, -0.1681380718946457, 0.07070013880729675, -0.628696620464325, 0.26026982069015503, 0.032733719795942307, -0.10853579640388489, 0.19278593361377716, -0.34983065724372864, 0.05588999763131142, -0.5559013485908508, 0.2748832404613495, -0.1620185375213623, -0.22512133419513702, 0.015736866742372513, -0.7081046104431152, -0.37181785702705383, 0.1711917370557785, -0.3997078239917755, 0.8394622206687927, 0.2727731764316559, -0.26740747690200806, 0.6511378884315491, 0.37509045004844666, 0.8482046723365784, -0.17481060326099396, 0.3627154529094696, 0.43064141273498535, 0.1995595246553421, 0.04118741676211357, 0.8428856730461121, 0.0866163969039917, -0.18370646238327026, -0.26685458421707153, -0.10729335993528366, 0.07681173831224442, -0.6872847080230713, 0.5804997086524963, 0.14319559931755066, -0.4101006090641022, 0.1632208526134491, -0.08483428508043289, -0.029891880229115486, -0.5256145000457764, 0.8258559703826904, -0.27155977487564087, -0.031733766198158264, -0.018309082835912704, 0.504320502281189, -0.42144516110420227, -0.15518485009670258, 0.6360174417495728, -0.8401745557785034, 0.324001282453537, -0.14192543923854828, -0.2225562185049057, 0.08347467333078384, 0.08332113921642303, -0.7294012904167175, -0.3086923062801361, 0.37653499841690063, 0.4170972406864166, -0.29851147532463074, -0.3218003213405609, 0.3751920461654663, 0.10763753205537796, -0.5664218068122864, 0.5220472812652588, 0.22012117505073547, -0.37704411149024963, -0.1093795895576477, -0.5303855538368225, 0.3032373785972595, 0.10801205039024353, -0.07745923101902008, 0.3067392408847809, 0.3611774444580078, 0.11913856863975525, 0.07288195937871933, -0.15611712634563446, 0.543376624584198, 0.279910147190094, 0.3280472457408905, -0.2539905905723572, -0.5266344547271729, 0.2059735208749771, 0.37596118450164795, 0.14395830035209656, 0.42822372913360596, -0.7676863074302673, 0.016192985698580742, -0.07868216931819916, -0.3320028781890869, 0.5072509050369263, -0.1525561511516571, -0.40017950534820557, 0.22697554528713226, -0.36855587363243103, -0.18553060293197632, 0.16648821532726288, -0.2089918851852417, -0.1714935153722763, 0.23134148120880127, -0.10901307314634323, 0.1635538786649704, -0.3747963309288025, 0.2652325928211212, -0.15950259566307068, 0.07036630809307098, -0.1274566948413849, 0.1834714561700821, -0.48776301741600037, -0.13908979296684265, 0.5573335289955139, -0.23584631085395813, 0.36075055599212646, 0.1754947453737259, 0.026563359424471855, -0.3197016417980194, -0.30438756942749023, -0.017888974398374557, -0.031090397387742996, 0.43294838070869446, -0.40995287895202637, 0.050593554973602295, 0.30391818284988403, 0.19417285919189453, 0.7409793734550476, -0.09708963334560394, -0.7852898240089417, 0.34636589884757996, 0.10475698858499527, -0.47539353370666504, -0.039115116000175476, 0.4486805498600006, 0.2802221477031708, -0.3785615861415863, -0.16200724244117737, -0.13842684030532837, -0.29278531670570374, -0.46768060326576233, -0.583259642124176, 0.1333876997232437, -0.09388457983732224, -0.34185823798179626, -0.0062275235541164875, 0.4687989354133606, 0.18740762770175934, -0.6712652444839478, 0.21132904291152954, -0.09914276003837585, 0.3981284201145172, 0.35398268699645996, -0.1755712926387787, -0.2756078541278839, 0.6094217896461487, 0.35599806904792786, -0.6402938365936279, 0.06115855649113655, -0.07761650532484055, -0.20078696310520172, -0.3232874870300293, -0.09520713239908218, -0.43994441628456116, -0.3756020963191986, -0.7033739686012268, -0.15825027227401733, 0.2851979732513428, -0.8026551604270935, 0.7418872117996216, 0.14776238799095154, 0.4710495173931122, -0.03182879090309143, -0.24400216341018677, -0.20521818101406097, 0.006622949615120888, 0.4627632200717926, -0.5847299695014954, -0.3693244755268097, 0.07902027666568756, 0.33202284574508667, -0.033505093306303024, 0.29865676164627075, 0.5373322367668152, 1.2569383382797241, 0.22379863262176514, -0.1659293919801712, -0.4496123194694519, 0.10090800374746323, 0.1867879182100296, -0.299318790435791, -0.16521435976028442, -0.20513691008090973, 0.2611425817012787, 0.303472101688385, -0.2059185653924942, -0.5671877264976501, -0.7127508521080017, 0.7549858689308167, 0.18687954545021057, 0.1070714145898819, 0.3070208430290222, 0.6171852946281433, 0.3578539192676544, 0.07201623916625977, 0.39817556738853455, -0.30529189109802246, 0.21629910171031952, 0.10082702338695526, 0.07802610099315643, -0.5012580752372742, -0.4251556694507599, 0.5923339128494263, -0.7179268598556519, 0.07583900541067123, -0.6475980281829834, -0.3986283838748932, -0.4536265432834625, 0.17276598513126373, -0.34314367175102234, -0.3509387969970703, -0.40738415718078613, -0.5661714673042297, -0.8644835948944092, 0.08163408935070038, 0.1402418166399002, -0.2550806999206543, 0.3521798253059387, 0.03464877977967262, 0.1540025770664215, -0.7177593111991882, 0.1425061970949173, 0.5616627335548401, -0.28455162048339844, -0.2786422371864319, 0.5840951204299927, 0.13259147107601166, 0.6352452039718628, -0.48661166429519653, -0.20910300314426422, 0.21980981528759003, 0.2613878846168518, 0.4840655028820038, 0.16424861550331116, -0.7354217767715454, 0.5391222834587097, 0.14784812927246094, 0.03797661513090134, 0.2298785150051117, -0.007333816960453987, 0.7510136961936951, 0.10909493267536163, 0.044691476970911026, 0.07620089501142502, -0.10405539721250534, 0.14356060326099396, 0.3791355788707733, -0.36813950538635254, -0.1769787222146988, 0.5277400612831116, 0.7635716795921326, 0.223866805434227, -0.27822017669677734, 0.5680637955665588, 0.11516374349594116, 0.49378910660743713, -0.723383903503418, -0.5159175992012024, -0.041171230375766754, 0.47321590781211853, 0.49167031049728394, 0.3954371213912964, -0.31255942583084106, 0.08744475245475769, 0.4711165130138397, 0.20857948064804077, 0.023529382422566414, -0.4384050965309143, -0.2062966227531433, 0.6674110293388367, 0.55573970079422, -0.7013837099075317, -0.4186828136444092, 0.1000966802239418, -0.4584689140319824, 0.0417771153151989, 0.5971634387969971, -0.42996883392333984, 0.0215747132897377, -0.14602145552635193, -0.500516414642334, 0.5122901201248169, -0.1545998603105545, 0.8872708082199097, -0.06614293158054352, 0.1805994212627411, 0.22076450288295746, 0.06857770681381226, -0.0529901348054409, -0.40198245644569397, 0.41556981205940247, -0.14522652328014374, -0.3404908776283264, 0.19979941844940186, 0.04428614675998688, -0.38555970788002014, 0.11130078881978989, -0.12648452818393707, 0.046055346727371216, 0.04239589348435402, -0.32837051153182983, 0.22190077602863312, -0.24879813194274902, -0.7080969214439392, -0.5737259387969971, -0.014727352187037468, -0.17036324739456177, -0.6562498211860657, 0.0692572072148323, 0.4320403039455414, 0.25242576003074646, -0.9760311841964722, -0.2677951753139496, -0.12146458029747009, -0.0017148643964901567, -0.2286674529314041, 0.12403915077447891, 0.42123210430145264, 0.7353115677833557, -0.1598128378391266, 0.4239570200443268, 0.5015784502029419, -0.08433132618665695, 0.41531798243522644, -0.5356677770614624, 0.8076807260513306, -0.2339021861553192, -0.6080636978149414, -0.11071962863206863, -0.02229205332696438, 1.0262584686279297, 0.32662007212638855, -0.14699576795101166, 0.38714343309402466, 0.725456178188324, 0.4549649953842163, 0.41629382967948914, -0.7753124237060547, -0.09927540272474289, -0.25431644916534424, 0.27444860339164734, -0.34581711888313293, 0.47936031222343445, 0.5318784117698669, -0.3344191014766693, 0.2711591124534607, 0.6673398613929749, 0.601030170917511, -0.6337856650352478, 0.5015832185745239, -0.35325494408607483, -0.06514857709407806, -0.2963128685951233, 0.1464250236749649, -0.3727427124977112, 0.6469480991363525, -0.3604062795639038, -0.16250289976596832, 0.0047286516055464745, -0.24925106763839722, -0.3735587000846863, 0.2861216068267822, 0.04381959140300751, -0.11916659772396088, -0.24587339162826538, -0.16112114489078522, -0.127457395195961, -0.775236189365387, -0.4733318090438843, 0.14749740064144135, 0.22194765508174896, 0.08832712471485138, -0.33563512563705444, 0.8846553564071655, 0.1318383514881134, -0.35747867822647095, 0.22308585047721863, 0.06108338385820389, 0.31196892261505127, 0.2405664175748825 ]
Semaphorin 3A (Sema3A) is a diffusible axonal chemorepellent that has an important role in axon guidance. Previous studies have demonstrated that Sema3a−/− mice have multiple developmental defects due to abnormal neuronal innervations. Here we show in mice that Sema3A is abundantly expressed in bone, and cell-based assays showed that Sema3A affected osteoblast differentiation in a cell-autonomous fashion. Accordingly, Sema3a−/− mice had a low bone mass due to decreased bone formation. However, osteoblast-specific Sema3A-deficient mice (Sema3acol1−/− and Sema3aosx−/− mice) had normal bone mass, even though the expression of Sema3A in bone was substantially decreased. In contrast, mice lacking Sema3A in neurons (Sema3asynapsin−/− and Sema3anestin−/− mice) had low bone mass, similar to Sema3a−/− mice, indicating that neuron-derived Sema3A is responsible for the observed bone abnormalities independent of the local effect of Sema3A in bone. Indeed, the number of sensory innervations of trabecular bone was significantly decreased in Sema3asynapsin−/− mice, whereas sympathetic innervations of trabecular bone were unchanged. Moreover, ablating sensory nerves decreased bone mass in wild-type mice, whereas it did not reduce the low bone mass in Sema3anestin−/− mice further, supporting the essential role of the sensory nervous system in normal bone homeostasis. Finally, neuronal abnormalities in Sema3a−/− mice, such as olfactory development, were identified in Sema3asynasin−/− mice, demonstrating that neuron-derived Sema3A contributes to the abnormal neural development seen in Sema3a−/− mice, and indicating that Sema3A produced in neurons regulates neural development in an autocrine manner. This study demonstrates that Sema3A regulates bone remodelling indirectly by modulating sensory nerve development, but not directly by acting on osteoblasts.
[ -0.004706779960542917, 0.0073233721777796745, -0.008818088099360466, 0.008320553228259087, -0.011472895741462708, -0.00914428848773241, 0.009788899682462215, 0.004989115055650473, -0.008468948304653168, -0.00046620937064290047, -0.006064004264771938, -0.0012333092745393515, -0.007520631421357393, 0.00949842669069767, -0.02462005987763405, 0.009911995381116867, -0.022617271170020103, 0.006414889357984066, 0.013649588450789452, -0.016858350485563278, -0.00815990287810564, -0.03653968125581741, 0.0077055636793375015, -0.008309422992169857, -0.007370219565927982, 0.02479439601302147, 0.014150170609354973, -0.015136975795030594, 0.015304013155400753, -0.004529581870883703, 0.020156744867563248, 0.006940493825823069, -0.003218466881662607, 0.008347810246050358, 0.0024906136095523834, 0.0034788325428962708, -0.010001325979828835, 0.027368083596229553, -0.010919376276433468, -0.005282953381538391, 0.015190302394330502, -0.01102130301296711, 0.01132860966026783, 0.004886425565928221, -0.0053432779386639595, -0.028980612754821777, -0.0013346981722861528, -0.010990288108587265, 0.01367219164967537, -0.0008497069356963038, -0.015638679265975952, 0.0007505598478019238, -0.006774516776204109, 0.02782333828508854, -0.004898588173091412, -0.023687196895480156, 0.012830797582864761, -0.028127839788794518, -0.011704031378030777, 0.006231962703168392, -0.0026736976578831673, -0.0077374400570988655, -0.0029173754155635834, 0.0018860907293856144, -0.005793478339910507, -0.0668841153383255, 0.016786329448223114, -0.0004856986925005913, 0.004005785100162029, -0.025035519152879715, -0.014422772452235222, 0.006582115776836872, -0.009446961805224419, 0.011609475128352642, 0.010835802182555199, -0.011068088002502918, -0.0033673294819891453, 0.03584422916173935, 0.007775681558996439, 0.001375444233417511, 0.019298795610666275, -0.0012045549228787422, 0.012226305902004242, 0.002618169877678156, 0.019632812589406967, 0.0032084269914776087, -0.02656213939189911, 0.002719089388847351, 0.0006778803654015064, 0.0035783429630100727, -0.007622254081070423, 0.0369076132774353, -0.0038040876388549805, 0.00410804245620966, -0.014372295700013638, -0.006647114641964436, -0.016996823251247406, -0.012180169112980366, 0.010426362976431847, -0.007394089829176664, -0.020546844229102135, -0.00024279975332319736, 0.010184809565544128, 0.0038418611511588097, -0.009644986130297184, 0.008673133328557014, 0.027759449556469917, 0.0016652580816298723, 0.033334001898765564, 0.011680892668664455, 0.0031081370543688536, -0.019831877201795578, -0.040319450199604034, 0.014771169051527977, -0.008401984348893166, -0.011822221800684929, -0.01962370239198208, 0.000984694343060255, 0.006786482408642769, -0.004485501907765865, -0.008691440336406231, -0.010368152521550655, 0.004713689908385277, -0.023054761812090874, 0.0048933858051896095, -0.02877810224890709, -0.025047168135643005, 0.0028791879303753376, 0.002713691210374236, -0.00442913081496954, -0.007690620608627796, 0.007926986552774906, -0.019395073875784874, 0.02999601513147354, -0.02579541876912117, -0.013203831389546394, -0.01937863603234291, 0.022235702723264694, 0.00483144773170352, -0.014766592532396317, -0.005830901674926281, 0.007056673988699913, 0.01363866962492466, 0.005006530322134495, 0.030232630670070648, -0.011265292763710022, -0.01236211322247982, 0.011297051794826984, -0.02837369777262211, -0.005580879747867584, -0.002571708522737026, -0.02516995742917061, -0.010391442105174065, -0.005125853698700666, -0.012025732547044754, -0.01606779918074608, -0.010947033762931824, -0.004988010507076979, 0.008763431571424007, 0.020438991487026215, -0.034056443721055984, 0.003204183652997017, -0.01917605847120285, 0.0064867595210671425, -0.017572743818163872, 0.020203981548547745, 0.009984995238482952, -0.007038284093141556, -0.014109372161328793, 0.010706736706197262, -0.002759238239377737, -0.016158316284418106, 0.018554046750068665, 0.010074706748127937, -0.004248607903718948, -0.00101994548458606, 0.0022696121595799923, 0.005690768361091614, -0.015183143317699432, 0.06643272936344147, -0.019023075699806213, 0.009623934514820576, 0.007416551932692528, 0.026468124240636826, -0.004640230908989906, -0.020638039335608482, 0.021815938875079155, -0.012707747519016266, 0.007111963350325823, 0.012083150446414948, -0.027774564921855927, 0.01281912811100483, -0.02947583980858326, 0.01342798676341772, -0.013120071962475777, 0.002877557184547186, 0.02612704411149025, 0.01176721416413784, -0.0125594362616539, 0.011698265559971333, 0.0064277262426912785, -0.011170228011906147, -0.013937093317508698, -0.009294888004660606, 0.002383028157055378, 0.01188379991799593, 0.005355133209377527, -0.008676907047629356, -0.026788104325532913, -0.0070941997691988945, 0.008799437433481216, 0.0046981992200016975, 0.0026474776677787304, -0.009221533313393593, 0.0008778846822679043, -0.008715223520994186, 0.006598357111215591, 0.01693895272910595, 0.0029479649383574724, -0.01004063431173563, -0.007660022005438805, -0.00692636426538229, 0.010581276379525661, 0.030868003144860268, 0.0274631530046463, -0.0076749203726649284, 0.0005079091060906649, 0.0069725955836474895, -0.0005562184378504753, -0.0018868010956794024, -0.005311776418238878, -0.024629710242152214, -0.013470197096467018, 0.023822655901312828, -0.03139108046889305, -0.0020748330280184746, 0.009605244733393192, -0.037056222558021545, 0.015303490683436394, -0.004544461145997047, -0.01231870986521244, 0.00021611060947179794, -0.019160401076078415, -0.021340128034353256, 0.0021880147978663445, 0.035992227494716644, -0.008200498297810555, -0.005575575865805149, 0.009073984809219837, 0.0031197085045278072, 0.006463445723056793, -0.009673400782048702, -0.00698332954198122, -0.013193479739129543, 0.0217268206179142, -0.020623140037059784, -0.01625949889421463, -0.021298574283719063, 0.023462913930416107, 0.011643067002296448, -0.0006419140845537186, 0.008580409921705723, -0.014053519815206528, 0.004961885511875153, -0.0023868391290307045, 0.0048107849434018135, -0.008995956741273403, 0.01024375669658184, 0.030639655888080597, 0.00004984787665307522, 0.00845208391547203, -0.0019415068672969937, 0.010029386729001999, -0.08172045648097992, 0.000302258413285017, 0.002006154740229249, -0.011116254143416882, 0.002842789050191641, 0.02156898006796837, 0.022322196513414383, -0.017932895570993423, -0.007798380218446255, -0.00844196043908596, 0.02994239330291748, -0.00759933702647686, -0.00799693912267685, -0.005260935984551907, -0.004438347648829222, -0.001970789860934019, 0.011770525947213173, 0.0028884648345410824, 0.005943090654909611, -0.01587224006652832, 0.0052652740851044655, -0.0206721480935812, 0.03741885721683502, -0.006336561404168606, -0.008296229876577854, 0.030947932973504066, 0.014749216847121716, -0.002378848847001791, -0.02131827548146248, 0.001258352305740118, -0.00931763369590044, 0.01843290403485298, -0.0025789709761738777, 0.01407296396791935, 0.012244867160916328, -0.015677794814109802, -0.036294396966695786, -0.013100368902087212, -0.01665973849594593, 0.01194059569388628, -0.02231775037944317, 0.010819400660693645, 0.026735562831163406, -0.0033961881417781115, -0.0023005828261375427, -0.014345718547701836, 0.012474341318011284, -0.01850895583629608, 0.02456407994031906, -0.011596116237342358, -0.011042988859117031, -0.004618524573743343, 0.014153354801237583, 0.020201602950692177, -0.015033643692731857, 0.004834380000829697, -0.002365418244153261, 0.019026339054107666, -0.007841668091714382, -0.004123002290725708, 0.008740926161408424, 0.018960630521178246, 0.008413170464336872, 0.027451997622847557, 0.012757607735693455, 0.012149332091212273, 0.019079934805631638, -0.0034442769829183817, -0.004264448769390583, 0.008909801952540874, -0.030575895681977272, -0.006874441169202328, -0.009815052151679993, -0.015165828168392181, -0.01060059480369091, -0.014105345122516155, -0.012835007160902023, -0.005896477028727531, -0.017180021852254868, -0.01915689744055271, 0.002573008881881833, -0.013499373570084572, -0.006128382403403521, -0.0007784796180203557, -0.022057291120290756, 0.019427776336669922, 0.005811984650790691, 0.024582967162132263, 0.012575690634548664, -0.013002092018723488, 0.023441946133971214, 0.04130473732948303, 0.026959333568811417, 0.01314299926161766, 0.006518223322927952, -0.00014783476945012808, -0.011892681941390038, -0.0014411486918106675, 0.03118164837360382, 0.00669170031324029, -0.0001425514928996563, -0.0026373867876827717, 0.02958318591117859, -0.004738500341773033, 0.0006309440941549838, 0.01448012888431549, -0.002144069643691182, 0.011842219159007072, -0.012442509643733501, 0.006351296324282885, 0.0013346732594072819, 0.02053959295153618, -0.003461535321548581, 0.011759079992771149, 0.007966983132064342, 0.0036284136585891247, -0.007500519976019859, 0.005473273806273937, 0.07245903462171555, 0.005803869105875492, -0.009865811094641685, -0.01104420330375433, 0.0261708814650774, -0.012494904920458794, -0.019523464143276215, 0.020139995962381363, -0.007268892601132393, -0.018615514039993286, 0.01093265786767006, -0.0083319041877985, 0.026517244055867195, 0.014668629504740238, -0.025859307497739792, 0.017766470089554787, 0.007399304769933224, -0.013567516580224037, 0.006989441812038422, 0.0002865880960598588, 0.016640465706586838, -0.013321302831172943, -0.01479497179389, -0.0016053726430982351, 0.0047709746286273, -0.01334473118185997, -0.004706442356109619, -0.012096709571778774, -0.015132477506995201, 0.0008483784622512758, -0.0074178846552968025, 0.011063281446695328, -0.010467896237969398, 0.01597825065255165, 0.024220101535320282, -0.011267082765698433, -0.009845864959061146, -0.022287804633378983, 0.02320249378681183, -0.013910433277487755, 0.007254594471305609, -0.008898190222680569, -0.013836249709129333, 0.00814690813422203, -0.0011687595397233963, -0.016055036336183548, 0.010550936684012413, -0.012236426584422588, 0.00869949534535408, -0.013980322517454624, 0.007569292560219765, -0.008138947188854218, 0.014492213726043701, 0.00524754635989666, 0.0019363944884389639, -0.005645835306495428, 0.020374517887830734, -0.0005144194583408535, 0.012977245263755322, -0.0014332291902974248, -0.010356389917433262, 0.025246936827898026, 0.019237501546740532, -0.021277837455272675, 0.007208196446299553, -0.01416949462145567, 0.004848821088671684, 0.004397227428853512, 0.004563264083117247, -0.021653933450579643, 0.006344422698020935, 0.0006422209553420544, 0.009333916008472443, 0.02108270302414894, -0.04534096270799637, -0.02069840580224991, 0.005258264020085335, 0.0033082449808716774, 0.00022547272965312004, 0.02270224690437317, 0.017436396330595016, -0.025013994425535202, -0.00266337301582098, 0.012268800288438797, 0.02200852707028389, -0.026441344991326332, 0.007442564703524113, -0.0746796578168869, 0.0178590789437294, 0.0008403647807426751, 0.0005568939377553761, 0.002791134174913168, -0.009111428633332253, -0.023098604753613472, -0.023534495383501053, -0.011187955737113953, -0.004007128067314625, 0.008589605800807476, -0.01035590935498476, 0.022111475467681885, 0.0047316718846559525, 0.007625089026987553, -0.003061120631173253, 0.020482420921325684, 0.0006681783124804497, -0.004964953288435936, -0.0008127238834276795, -0.022462956607341766, -0.011066725477576256, 0.004573248326778412, 0.01848292537033558, -0.021696101874113083, -0.08114685118198395, -0.005792079959064722, 0.004823541268706322, 0.0011127861216664314, 0.006405141204595566, -0.009689966216683388, 0.013931376859545708, -0.004869323223829269, -0.010928832925856113, -0.014681732282042503, -0.012658202089369297, -0.012669358402490616, 0.007699989713728428, 0.0060010673478245735, -0.01719868928194046, -0.010923672467470169, 0.004582654219120741, 0.0010310427751392126, -0.026697896420955658, -0.010910829529166222, 0.007452913094311953, -0.016882840543985367, -0.0061416178941726685, -0.018733594566583633, -0.011387701146304607, 0.01204765122383833, -0.03785444051027298, 0.015580820851027966, -0.012577340938150883, 0.005481790751218796, -0.005850968882441521, 0.004688244313001633, 0.005102510564029217, -0.025926627218723297, -0.021546531468629837, -0.015833023935556412, -0.026375245302915573, 0.0003772599156945944, -0.016439732164144516, -0.02229558676481247, -0.003991805016994476, -0.011044288985431194, -0.001773111056536436, 0.01226661168038845, -0.006008558440953493, -0.0031300662085413933, 0.007364616263657808, -0.010852828621864319, -0.0015704394318163395, 0.025023195892572403, 0.009447935037314892, -0.009823516011238098, -0.010403970256447792, -0.002917821519076824, -0.007127021439373493, 0.005131837446242571, -0.0007624216377735138, -0.007103221025317907, 0.009097177535295486, 0.016774345189332962, -0.006532388273626566, -0.004120036493986845, -0.010321992449462414, 0.07177400588989258, -0.008908368647098541, 0.0063630156219005585, -0.001680912566371262, 0.011425681412220001, 0.008778296411037445, -0.012038568034768105, -0.005264030769467354, -0.016895899549126625, 0.00022650090977549553, 0.013857352547347546, 0.005354322027415037, 0.012051042169332504, 0.014584239572286606, -0.014133190736174583, -0.02758173830807209, 0.02603132277727127, 0.008181166835129261, -0.0005122986622154713, 0.009289901703596115, -0.018186897039413452, 0.012524610385298729, -0.0011454937048256397, -0.003831506008282304, 0.004503551870584488, 0.009012077935039997, -0.01991046592593193, 0.01856108382344246, -0.002232298720628023, -0.007903425954282284, -0.0058359866961836815, -0.006134561263024807, 0.0005042921984568238, 0.01131008006632328, 0.0202329158782959, 0.014168093912303448, 0.005604394245892763, 0.009356649592518806, -0.026160798966884613, -0.026116447523236275, -0.004155448637902737, -0.0016408078372478485, -0.002719337120652199, -0.007526692934334278, 0.00629116827622056, 0.007442950736731291, -0.005470558535307646, 0.004850421100854874, 0.004772653803229332, 0.00427373219281435, 0.012587646953761578, 0.01055985875427723, 0.015049208886921406, 0.010595220141112804, 0.010393287986516953, 0.011547621339559555, -0.019960548728704453, 0.007644974626600742, -0.008356615900993347, 0.0034916549921035767, -0.019859563559293747, -0.0016196278156712651, -0.007315253838896751, -0.01980271376669407, 0.0007546411361545324, -0.009934838861227036, 0.0015034978277981281, -0.014456985518336296, -0.0062445830553770065, 0.018303420394659042, 0.004117064643651247, -0.019807178527116776, 0.007904889062047005, -0.0034050182439386845, 0.008628315292298794, 0.006782218813896179, -0.0020538826938718557, -0.022083332762122154, 0.03500792384147644, 0.014988001435995102, -0.007333447225391865, 0.0024766232818365097, -0.01927764154970646, -0.016123495995998383, -0.008090918883681297, -0.019051972776651382, -0.0012203361839056015, -0.014482008293271065, 0.0029415455646812916, 0.008115151897072792, 0.009867875836789608, 0.0073953294195234776, 0.00906550046056509, 0.03749905899167061, 0.006677335128188133, 0.033754754811525345, -0.019764713943004608, 0.0028175017796456814, -0.018162697553634644, 0.013866030611097813, 0.037197161465883255, 0.009646184742450714, 0.00512867234647274, -0.013874251395463943, -0.015942558646202087, -0.0037146685644984245, -0.0058373138308525085, -0.014513482339680195, 0.005534680560231209, 0.003973359242081642, -0.017002901062369347, 0.0020213229581713676, 0.0066472003236413, 0.016398053616285324, -0.00702402601018548, 0.009776510298252106, -0.02194203808903694, 0.003646812867373228, -0.000883015338331461, -0.013085659593343735, 0.010700011625885963, -0.008303903043270111, -0.033710211515426636, 0.0072388057596981525, -0.02619316801428795, -0.02827744372189045, -0.011883425526320934, 0.04333347827196121, -0.018075857311487198, -0.006513397209346294, 0.025025688111782074, 0.028571080416440964, -0.007050027139484882, -0.02634182758629322, -0.017126187682151794, 0.01431962288916111, -0.0012679905630648136, -0.02585110254585743, 0.012219682335853577, -0.031254567205905914, 0.013267429545521736, -0.02625148743391037, -0.0016302787698805332, -0.004443153273314238, 0.005848354659974575, 0.025192558765411377, -0.004055001772940159, -0.02352949045598507, 0.009053640067577362, 0.01350933313369751, 0.0025141877122223377, 0.020638905465602875, 0.029410382732748985, -0.009421726688742638, -0.016223052516579628, 0.026278886944055557, -0.005774027202278376, 0.015739602968096733, 0.014370238408446312, -0.005718786735087633, -0.012727010995149612, 0.03360791131854057, 0.017491742968559265, 0.02141774818301201, 0.02617434784770012, 0.013564486987888813, -0.020504772663116455, -0.004544823430478573, -0.00805874727666378, 0.0024694923777133226, 0.01605295017361641, 0.008593259379267693, -0.01571367308497429, 0.00033382908441126347, -0.009216188453137875, -0.005373143590986729, 0.00456020375713706, -0.001993392128497362, 0.022179847583174706, -0.001894465647637844, 0.005507779307663441, -0.0092507004737854, 0.004817675333470106, -0.004200268536806107, -0.00566550437361002, 0.01565355435013771, -0.011973254382610321, -0.0033080275170505047, -0.005042013246566057, 0.0032792803831398487, -0.0069537837989628315, 0.0030197640880942345, 0.020883211866021156, 0.0009400008711963892, 0.006980661768466234, 0.013897126540541649, -0.003783878870308399, -0.010050470009446144, -0.0034673234913498163, 0.006656757555902004, -0.0002736037131398916, -0.013571185991168022 ]
[ -0.1657310575246811, 0.2793261408805847, 0.04748589172959328, -0.3754481077194214, -0.533662736415863, 0.0532892644405365, 0.23974737524986267, -0.6201835870742798, 0.16818514466285706, -0.1970890611410141, -0.13654673099517822, -0.172134131193161, -0.5382888913154602, -0.02096402272582054, -0.30528298020362854, 0.7462500333786011, 0.020347988232970238, 0.6282961964607239, -0.009481154382228851, -0.17777901887893677, -0.16481520235538483, 0.11199937015771866, 0.7768884897232056, -0.5102517008781433, 0.26603811979293823, 0.4352704882621765, 0.7340607047080994, 0.4129892587661743, 0.19257360696792603, -0.06051027402281761, -0.36246711015701294, 0.40362781286239624, -0.04575221613049507, -0.07754280418157578, -0.08435187488794327, 0.5114983320236206, -0.3045884668827057, -0.043294306844472885, -0.09521990269422531, -0.059098031371831894, -0.4560205638408661, -0.3712581694126129, 0.021094396710395813, 0.2545892298221588, -0.40977242588996887, -0.020326683297753334, -1.5931307077407837, 0.6547496914863586, -0.5130760669708252, -0.16613538563251495, -0.3452675938606262, 0.15647707879543304, 0.48148804903030396, -0.31959378719329834, 0.5543236136436462, -0.3626871407032013, -0.8731943368911743, -0.30976274609565735, 0.37935131788253784, -0.4263445734977722, -0.0507194846868515, 0.07987916469573975, -0.15353477001190186, 0.417388916015625, 0.008507807739078999, 0.5581498146057129, -0.24242433905601501, -0.3610419034957886, -0.5372642278671265, 0.2788580060005188, 0.46207258105278015, -0.2562863230705261, -0.366310179233551, 0.4448983371257782, -0.24812494218349457, -0.12214237451553345, -0.432627409696579, 0.06462498754262924, -0.01700453646481037, 0.23099102079868317, 0.24320392310619354, 0.49527132511138916, 0.8903549313545227, -0.10563487559556961, 0.15057389438152313, 0.2509482800960541, -0.23870967328548431, 0.6550140976905823, -0.4502180814743042, -0.004558762069791555, -0.2254374474287033, -0.32121166586875916, 0.6373828053474426, 0.2922396957874298, -0.2595937252044678, 0.36462751030921936, -0.30671975016593933, -0.10905592143535614, 0.1868096888065338, 0.24793000519275665, -0.12953436374664307, -0.14112330973148346, 0.39412298798561096, -0.7285855412483215, -0.40851765871047974, -0.08514054119586945, -0.28477001190185547, -0.6251217126846313, -0.6768637895584106, 0.5970090627670288, -0.9635168313980103, 0.05721668154001236, -0.23847824335098267, -0.48333740234375, 0.14394626021385193, 0.2213190197944641, 0.3352416455745697, 0.2343926727771759, -0.1285511553287506, 0.24071289598941803, 0.44183748960494995, 1.344457745552063, -0.2205718457698822, -0.3326852023601532, 0.19464920461177826, -0.266105979681015, 0.02950749732553959, -0.08706758171319962, -0.45933273434638977, 0.6116008162498474, 0.15227951109409332, 0.7672350406646729, -0.3442768454551697, 0.18704062700271606, -0.027334999293088913, -0.6656858325004578, 0.04945359379053116, -0.22484706342220306, -0.11448491364717484, -0.037121281027793884, -0.6647697687149048, 0.24659717082977295, -0.8422165513038635, -0.1824932098388672, 0.26172590255737305, -0.49016883969306946, 0.0009237391059286892, 0.265435129404068, -0.3278343081474304, 0.01959390752017498, 0.036949023604393005, -0.4946259558200836, -0.15892177820205688, 0.1896868199110031, -0.30162936449050903, -0.14158479869365692, 0.2935611307621002, -0.14431245625019073, 0.4195687472820282, 0.1715506762266159, 0.11933533847332001, -0.3160175681114197, -0.3199789524078369, 0.26554909348487854, 0.4856756031513214, -0.08727645128965378, 0.3873275816440582, 0.26465070247650146, 0.31293290853500366, -0.1345350593328476, 0.11574923992156982, -0.4152703881263733, -0.00662730960175395, -0.1659204214811325, -0.03994964435696602, -0.3463536500930786, -0.2443402111530304, -0.1479242444038391, 0.11783695220947266, -0.2580450773239136, -0.6917752027511597, -0.5679513216018677, -0.22743861377239227, -0.058658845722675323, 0.43912309408187866, 0.2452937513589859, 0.8234541416168213, 0.053405627608299255, -0.18689371645450592, -0.39182499051094055, -0.37275606393814087, -0.32944586873054504, 0.43247973918914795, -0.5023021101951599, 0.9981523752212524, -0.09361018985509872, -0.4440596103668213, 0.9612597227096558, 0.3399277329444885, 0.3126404881477356, -0.20104344189167023, -0.538087785243988, 0.5638835430145264, -0.14845097064971924, -0.072205550968647, 0.3117315173149109, 0.2028779685497284, 0.5722642540931702, 0.44260233640670776, -0.025292979553341866, 0.3097645938396454, -0.7063159942626953, -0.0077394964173436165, -0.0132684875279665, 0.5201541781425476, -0.6436295509338379, 0.15898095071315765, -0.1931668072938919, -0.40530866384506226, 0.3161608576774597, 0.36948418617248535, -0.35151222348213196, 0.0271744504570961, 0.5877495408058167, -0.23458591103553772, 0.6232945322990417, 0.6760333180427551, -0.18077042698860168, 0.6416636109352112, 0.38921457529067993, 0.3121389150619507, -0.563628613948822, 0.589224636554718, -0.05084768682718277, 0.14941981434822083, -0.0759187787771225, 0.0027692189905792475, -0.04998262599110603, 0.1233820766210556, -0.3740187883377075, -0.05089963972568512, 0.3755722939968109, -0.3338249623775482, -0.27488651871681213, 0.3352780044078827, -0.04012389853596687, 0.2323891520500183, 0.45459914207458496, -1.1743425130844116, -0.07359053939580917, -0.06591711938381195, 0.07304346561431885, 0.1596943885087967, -0.42846494913101196, 0.1446424424648285, 0.20709607005119324, -0.11088839918375015, -0.4017139673233032, 0.27795854210853577, -0.5076021552085876, -0.10809850692749023, 0.1309337615966797, 0.34509754180908203, -0.0254341010004282, -0.17015621066093445, -0.33787965774536133, -0.2583216428756714, -0.281772255897522, 1.1259915828704834, 0.8938613533973694, 0.9196670055389404, -0.3760300278663635, -1.1345689296722412, 0.19534215331077576, -0.12808629870414734, -0.43215203285217285, 0.10393346846103668, 0.15123935043811798, -0.4727592170238495, -0.2788097858428955, 0.012050862424075603, 0.45181941986083984, 0.9438607692718506, 0.07972158491611481, -0.5987439155578613, -0.13945609331130981, 0.060987167060375214, -0.24182353913784027, -0.4009861648082733, -0.4058310389518738, -0.49684813618659973, 0.03755573928356171, -0.26597896218299866, -0.054113470017910004, -0.22786454856395721, 0.394641250371933, -0.06143989786505699, 0.39026421308517456, 0.941582441329956, -0.33437371253967285, -0.13014909625053406, 0.07245126366615295, -0.2032427191734314, 0.09758130460977554, 0.19294863939285278, 0.0643867626786232, -0.24630814790725708, 0.5292204022407532, -5.7472734451293945, 0.1518866866827011, 0.07477141171693802, -0.3641449809074402, 0.3573950529098511, 0.2811596095561981, 0.5115182399749756, -0.1086648479104042, 0.2971076965332031, -0.043781403452157974, 0.012181637808680534, 0.23745502531528473, 0.33848845958709717, -0.2102547436952591, -0.24760133028030396, -0.22129149734973907, -0.06681188195943832, -0.23421324789524078, 0.6643040180206299, 0.3579833209514618, 0.404453307390213, -0.0537094920873642, -0.00015873533266130835, 0.5648190975189209, -0.19410525262355804, -0.13309802114963531, -0.7340184450149536, 0.07917235791683197, 0.08861404657363892, -0.8774828314781189, 0.47864216566085815, -0.20055438578128815, -0.2750450670719147, -0.4645257294178009, 0.5956185460090637, -0.043009333312511444, 0.4091445803642273, 0.106965571641922, -0.4406203329563141, -0.7773323059082031, 0.7393877506256104, 0.4340795874595642, 0.23756000399589539, 0.322969526052475, 0.8382154107093811, -0.36056867241859436, -0.3655790686607361, 0.2595866918563843, -0.18015357851982117, 0.673442006111145, 0.09262379258871078, -0.4785115420818329, -0.12816181778907776, 0.316074937582016, 0.3492114543914795, 0.37030014395713806, 0.0925140306353569, 0.0203369352966547, -0.49787628650665283, 0.3001311421394348, -0.18456411361694336, -0.02438347227871418, -0.6750321388244629, -0.5707176327705383, -0.341052770614624, 0.11670665442943573, -0.7543787956237793, 0.23252302408218384, 0.2289445847272873, -0.6547593474388123, -0.35784587264060974, 0.18101394176483154, -0.14254991710186005, -0.7643495202064514, 1.28835928440094, 0.021797901019454002, 0.4190778434276581, -0.25215625762939453, -0.44687336683273315, 0.30462053418159485, -0.19958658516407013, -0.25866198539733887, 0.12147850543260574, 0.5304653644561768, 0.3153766095638275, -0.021836336702108383, 0.3443668782711029, 0.14025211334228516, -0.08914638310670853, 0.4132997691631317, 0.552718997001648, -0.3010169267654419, -0.007308299653232098, 0.4581402540206909, 0.254236102104187, -0.29721832275390625, 0.01239454373717308, 0.13472062349319458, 1.4260497093200684, 0.023119403049349785, 1.0078051090240479, 0.31016260385513306, -0.566637396812439, -0.6700372099876404, -0.05893383547663689, 0.18680568039417267, -0.2990087866783142, 0.11696275323629379, 0.6404790878295898, -0.772056519985199, 0.08668918907642365, 0.11963146924972534, -0.6696978807449341, -0.10403993725776672, 1.0658068656921387, -0.23783890902996063, -0.0935368686914444, 0.02006663754582405, 0.4482401907444, -0.09495529532432556, -0.30931562185287476, 0.18033744394779205, -0.8200646638870239, 0.32004380226135254, -0.31706729531288147, -0.1513131558895111, -0.17983044683933258, 0.3767501413822174, -0.7659303545951843, -0.05020058527588844, 0.48423194885253906, 0.3463967740535736, -0.5447282195091248, 0.045939598232507706, 0.3139117658138275, -0.35463935136795044, -0.23810119926929474, 0.6610190272331238, 0.36854317784309387, -0.8082584738731384, 0.49378615617752075, -0.42744332551956177, 0.19050274789333344, 0.12162639200687408, 0.2438722550868988, -0.09465979039669037, 0.20300039649009705, 0.5160234570503235, -0.39822399616241455, -0.08550233393907547, 0.10834140330553055, -0.3444286286830902, 0.17233046889305115, 0.05001736804842949, -0.09339351207017899, 0.4729093909263611, 0.309471070766449, 0.08122482150793076, 0.2832964360713959, -0.8315706849098206, 0.1490245759487152, 0.028097597882151604, -0.49535125494003296, 0.20713818073272705, -0.13777077198028564, -0.4549996852874756, -0.13168874382972717, -0.11494972556829453, 0.38386040925979614, 0.11478641629219055, -0.36634084582328796, 0.026123719289898872, 0.07452423125505447, -0.17992918193340302, -0.14084409177303314, -0.15765900909900665, -0.5911960601806641, -0.11149892956018448, -0.30845868587493896, -0.1114099845290184, -0.17130056023597717, -0.3247329592704773, 0.1072651669383049, -0.06878839433193207, 0.17010627686977386, 0.3917132318019867, -0.21918368339538574, -0.34642040729522705, -0.3401123881340027, -1.036878228187561, 0.12137127667665482, 0.03715449944138527, 0.14891351759433746, -0.19333231449127197, 0.23509855568408966, 0.09295999258756638, 0.43483057618141174, 0.7079609632492065, -0.03684579208493233, -0.5875464081764221, 0.08464258909225464, -0.03982710838317871, -0.40651074051856995, -0.012989578768610954, 0.43272507190704346, -0.22811968624591827, 0.20261436700820923, 0.47106027603149414, -0.27756378054618835, -0.2838687300682068, -0.3158889710903168, -0.3497008681297302, -0.09419489651918411, -0.047567300498485565, -0.15083014965057373, 0.07485420256853104, 0.1748952865600586, -0.5235872268676758, -0.3165184259414673, -0.11306547373533249, 0.3474992513656616, -0.2654223144054413, 0.30621445178985596, -0.010005401447415352, -0.47254887223243713, -0.055266574025154114, 0.44089818000793457, -0.5193451642990112, 0.6640768647193909, -0.14748701453208923, -0.1887800246477127, 0.08407475054264069, 0.13863477110862732, 0.24917207658290863, -0.48934412002563477, -0.390598863363266, -0.5059413909912109, -0.04720192402601242, 0.08401437848806381, 0.8883345723152161, 0.07784293591976166, 0.275040864944458, -0.18303543329238892, 0.10786740481853485, -0.18952490389347076, 0.23510214686393738, 0.14020122587680817, -0.24443061649799347, -0.4409118890762329, 0.25660452246665955, 0.5589028596878052, -0.14264465868473053, 0.28077074885368347, 0.6787183284759521, 0.9396456480026245, -0.32216760516166687, 0.13029690086841583, -0.5009703636169434, -0.314566045999527, 0.11728228628635406, -0.30509668588638306, 0.6756417155265808, 0.316525936126709, 0.27810436487197876, 0.04244149103760719, 0.05203014239668846, -0.22291350364685059, -0.8310139775276184, 1.1039093732833862, -0.17972035706043243, -0.18146124482154846, -0.022906474769115448, 0.24460062384605408, 0.5556517839431763, -0.36802956461906433, 0.14970174431800842, 0.11352480202913284, 0.1773584932088852, -0.03093336895108223, 0.3158548176288605, -0.22962351143360138, -0.18639865517616272, 0.45146024227142334, -0.7430666089057922, 0.20615294575691223, -0.8855865001678467, -0.07472189515829086, -0.48864713311195374, -0.2153644859790802, 0.08812116831541061, -0.2798311412334442, 0.035531796514987946, -0.8043321371078491, -0.7515948414802551, -0.4015234708786011, 0.2687847316265106, -0.20284341275691986, 0.24113251268863678, -0.2616261839866638, 0.2227402925491333, -0.21962784230709076, 0.2280290424823761, 0.6391935348510742, -0.08511221408843994, -0.6319755911827087, 0.038031209260225296, 0.1484079658985138, -0.5194362998008728, -0.7320284247398376, -0.016547637060284615, -0.6228183507919312, -0.32175907492637634, 0.5451377630233765, 0.15704230964183807, -0.840530514717102, 0.23868215084075928, 0.24013185501098633, 0.18294185400009155, -0.01607910916209221, 0.5274375081062317, 0.23114262521266937, 0.07027577608823776, 0.6332426071166992, 0.3003654181957245, -0.6703361868858337, 0.12482885271310806, 0.4003148376941681, 0.34414172172546387, -0.07887475937604904, 0.39880067110061646, 0.20297583937644958, 0.23238226771354675, 0.23763687908649445, 0.81141597032547, 0.36073780059814453, -0.08857511729001999, 0.459734171628952, 0.03373147174715996, 0.0808662548661232, -0.04646143689751625, 0.367647647857666, 0.7891267538070679, -0.08422278612852097, -0.1483812928199768, 0.5292433500289917, -0.09154622256755829, 0.3002125918865204, 0.34294506907463074, -0.15651479363441467, 0.5228883624076843, 0.09236465394496918, -0.058580223470926285, -0.36783042550086975, 0.5591491460800171, -0.490230530500412, 0.327090859413147, 0.5022045373916626, -0.6005092859268188, -0.3257049024105072, 0.4024956524372101, -0.5585503578186035, 0.2152484655380249, -0.023196730762720108, 0.7300538420677185, -0.4554995894432068, -0.35765770077705383, 0.05741298571228981, -0.5934497714042664, 0.43043023347854614, -0.1574281007051468, -0.21912041306495667, 0.2863718271255493, -0.5538989305496216, 0.4040035903453827, 0.12255220860242844, 0.10058411210775375, 0.27585679292678833, -0.36786890029907227, 0.08208788931369781, 0.1371224820613861, -0.41358622908592224, 0.34580132365226746, -0.1723925918340683, -0.8985422849655151, -0.5519478917121887, -0.502379834651947, 0.03214485943317413, -0.09274757653474808, 0.23602527379989624, -0.13268934190273285, 0.04915926977992058, -0.368326872587204, 0.022062649950385094, -0.49501392245292664, 0.40222299098968506, -0.3182174861431122, 0.266417533159256, 0.08436303585767746, 0.6776245832443237, 0.5124109983444214, 0.15033267438411713, 0.4221040904521942, 0.08117526024580002, 0.01028282567858696, -0.14423200488090515, 0.5141091346740723, 0.0076520503498613834, -0.1466359794139862, -0.6927838325500488, 0.0686451867222786, 0.8342508673667908, 0.6220585703849792, -0.16063235700130463, 0.006053565070033073, 0.3133080005645752, 0.2483857423067093, 0.2612314820289612, -0.6256067752838135, 0.05549458786845207, -0.5011341571807861, -0.14072351157665253, -0.3547549247741699, 0.46690693497657776, 0.05730312317609787, -0.46192967891693115, -0.10519002377986908, 0.30779534578323364, 0.2501291334629059, -0.582511842250824, 0.02019236795604229, -0.26874977350234985, -0.30591243505477905, -0.13267961144447327, 0.3303188383579254, -0.9244372844696045, 0.18310682475566864, -0.6095055937767029, -0.07427146285772324, -0.17045527696609497, -0.45940056443214417, -0.29186394810676575, 0.22158212959766388, 0.1257207989692688, 0.13909320533275604, 0.042306311428546906, 0.4442111551761627, -0.37748634815216064, -1.0126746892929077, -0.30930137634277344, 0.13871318101882935, -0.014000934548676014, -0.7119472026824951, 0.2521040439605713, 0.10002725571393967, 0.3422643542289734, -0.013872521929442883, 0.11380735039710999, -0.27925214171409607, -0.10293944925069809, 0.4262857437133789 ]
The direct lineage reprogramming of one specialized cell type into another using defined factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of differentiated cells. With the rapid increase in cell types generated through direct conversion in recent years, this strategy has become a promising approach for producing functional cells. Here, we review recent advances in lineage reprogramming, including the identification of novel reprogramming factors, underlying molecular mechanisms, strategies for generating functionally mature cells, and assays for characterizing induced cells. We also discuss progress toward the application of lineage reprogramming and the major future challenges for this strategy.
[ -0.0022338014096021652, 0.014982199296355247, -0.012380399741232395, 0.013913856819272041, -0.01140141673386097, -0.025012526661157608, 0.010197324678301811, -0.005829206667840481, -0.016624869778752327, -0.0196123905479908, -0.0007141779642552137, 0.016842560842633247, 0.016757696866989136, 0.010606518015265465, 0.010385938920080662, 0.004224739503115416, -0.011719568632543087, 0.019211377948522568, 0.004890114534646273, -0.026710009202361107, -0.012957130558788776, 0.0065917703323066235, 0.009985269978642464, -0.017336055636405945, 0.012990674003958702, 0.01363203302025795, 0.015224937349557877, -0.007202181499451399, -0.010752402245998383, -0.01780865341424942, 0.009004425257444382, -0.008968847803771496, 0.0007031853310763836, 0.014329229481518269, -0.0036061317659914494, 0.0005236552096903324, 0.004797797184437513, 0.020269256085157394, 0.005451211240142584, -0.005008932668715715, 0.013558708131313324, -0.008211895823478699, 0.008288362994790077, -0.0062346672639250755, -0.00741517823189497, -0.02074509486556053, -0.004692128859460354, -0.01631111279129982, -0.005829573143273592, 0.010944046080112457, -0.01017422042787075, -0.002079254947602749, -0.005618516355752945, 0.012713262811303139, -0.006742236204445362, -0.014955086633563042, 0.019939888268709183, 0.005129446275532246, 0.020930763334035873, -0.0017814161255955696, -0.014962682500481606, -0.02698037587106228, -0.00020607840269804, -0.013344449922442436, -0.002566381823271513, -0.06712223589420319, -0.01658456400036812, 0.016915252432227135, 0.008014606311917305, -0.02654552459716797, 0.0021644718945026398, 0.010248422622680664, -0.00414824765175581, -0.029887570068240166, -0.006107221823185682, -0.020519504323601723, -0.019462816417217255, 0.020616279914975166, -0.011345535516738892, -0.013490626588463783, -0.010182608850300312, -0.01270511094480753, 0.028719281777739525, 0.02597735822200775, -0.009991629049181938, 0.017869247123599052, 0.005761047825217247, 0.010908315889537334, 0.011475101113319397, -0.02254086174070835, -0.010222799144685268, -0.014768877997994423, -0.0026641525328159332, 0.006680244579911232, 0.005055491346865892, 0.0034013064578175545, 0.006645666901022196, -0.007791961543262005, 0.002617188962176442, 0.019303414970636368, -0.02329842932522297, 0.0062798806466162205, 0.01513293944299221, -0.004346304573118687, -0.005669815931469202, 0.01419520378112793, 0.01441485621035099, 0.0051976642571389675, -0.007027207873761654, 0.005921682342886925, -0.008604779839515686, 0.002411596942692995, -0.00007527065463364124, 0.004906662739813328, 0.016695842146873474, 0.016740722581744194, -0.001693111378699541, -0.013805950060486794, 0.009645981714129448, -0.005315764807164669, 0.02322537824511528, 0.025768810883164406, -0.004577872343361378, 0.004564114846289158, 0.006595084443688393, -0.021744223311543465, -0.0316019132733345, 0.0023940703831613064, 0.004221556708216667, 0.0066835153847932816, -0.008114908821880817, 0.005631555337458849, 0.022581303492188454, -0.02810642495751381, 0.011027269065380096, 0.005680873524397612, -0.029219631105661392, -0.009762933477759361, -0.0009668436832726002, -0.013448107987642288, -0.00288974167779088, 0.006656980141997337, -0.0024343987461179495, 0.008823604322969913, 0.015777524560689926, -0.010612856596708298, -0.024830587208271027, 0.005410169716924429, 0.014348480850458145, -0.03704185038805008, -0.010800999589264393, 0.0017233728431165218, -0.0005038052331656218, -0.010042856447398663, 0.004066742490977049, 0.015232852660119534, -0.019903091713786125, 0.010870297439396381, -0.013387033715844154, 0.010877054184675217, 0.006795805878937244, -0.008380191400647163, 0.01759142242372036, 0.00864503812044859, -0.003320119809359312, 0.007579567842185497, 0.00431121326982975, -0.004386689513921738, -0.03716941177845001, 0.004328353796154261, -0.0075672464445233345, 0.02396482229232788, -0.007221736013889313, 0.013215435668826103, -0.00480042677372694, 0.002650258829817176, 0.010592685081064701, 0.008405741304159164, -0.009269452653825283, 0.06714869290590286, 0.010283311828970909, 0.010704257525503635, -0.00427003251388669, -0.006166870705783367, -0.003965872339904308, -0.01671188324689865, 0.01774490438401699, -0.014793656766414642, -0.0060614170506596565, 0.009141244925558567, -0.0032825982198119164, -0.006855587009340525, -0.00501328706741333, -0.014816829934716225, -0.01868508569896221, 0.003466073190793395, 0.005563411861658096, 0.005056374240666628, 0.001149095711298287, 0.0053625889122486115, 0.006452916190028191, -0.011414884589612484, 0.006273668725043535, -0.018628165125846863, -0.01023893989622593, 0.0013552098535001278, -0.012752301059663296, -0.005895067472010851, -0.004305505659431219, -0.00041571445763111115, 0.00674455426633358, -0.011882185935974121, -0.0021129450760781765, -0.012170420959591866, 0.011525245383381844, 0.0013522852677851915, -0.001108000986278057, -0.03517840802669525, 0.012610540725290775, -0.020066112279891968, 0.0035231392830610275, -0.0005675582215189934, 0.007789234165102243, -0.0019050792325288057, -0.0051553454250097275, 0.001301253098063171, -0.0072473641484975815, 0.015423080883920193, -0.0014826108235865831, -0.020986633375287056, 0.0069920956157147884, -0.019926123321056366, -0.010012253187596798, 0.021672040224075317, -0.013600615784525871, 0.008719457313418388, 0.009530669078230858, -0.014323141425848007, 0.024253368377685547, -0.0144300926476717, -0.02920902892947197, 0.005660069640725851, 0.026743287220597267, -0.013889224268496037, -0.011673427186906338, 0.001535769086331129, 0.032626938074827194, 0.010217770002782345, 0.0018456510733813047, -0.02193034440279007, 0.002762358170002699, 0.0004810364916920662, -0.0003164578229188919, -0.003256833180785179, 0.02149486169219017, 0.010203687474131584, -0.008045364171266556, 0.002368916990235448, 0.024021700024604797, -0.009848367422819138, 0.0014707362279295921, 0.004301306791603565, 0.0017377985641360283, -0.02129172347486019, -0.02847839519381523, -0.0020187166519463062, 0.012107155285775661, -0.0003402039874345064, 0.008016192354261875, -0.004598789848387241, 0.007387999445199966, -0.008718381635844707, 0.002734975889325142, -0.08132176846265793, -0.006151490844786167, 0.0088593615218997, -0.00039130402728915215, 0.014556553214788437, -0.039529599249362946, 0.004194819834083319, -0.013868432492017746, -0.01138084102421999, 0.011137877590954304, 0.011598973535001278, 0.0032252671662718058, -0.006855936720967293, 0.004509092308580875, -0.024438705295324326, -0.02037903480231762, 0.01092584803700447, 0.020805567502975464, -0.018732856959104538, -0.036170512437820435, -0.010539498180150986, -0.028328221291303635, -0.0049882628954946995, -0.0004105903208255768, 0.008850873447954655, 0.010175641626119614, 0.009707920253276825, 0.0021496806293725967, -0.04201985150575638, 0.003003249643370509, -0.013807200826704502, -0.023015012964606285, 0.0266646109521389, 0.0018921736627817154, -0.009399281814694405, 0.008225330151617527, -0.0003530564717948437, -0.01763315498828888, -0.01927792653441429, 0.021882347762584686, 0.0032090405002236366, 0.017001599073410034, 0.0062405504286289215, 0.013410693034529686, 0.00596625218167901, 0.005137522239238024, 0.028165793046355247, 0.018589401617646217, 0.021058987826108932, 0.0036377678625285625, 0.00455828569829464, 0.009400265291333199, 0.012783756479620934, 0.01436366606503725, -0.012134894728660583, -0.014398308470845222, -0.01415795274078846, -0.009967364370822906, -0.016107363626360893, -0.007198274601250887, 0.001227634958922863, -0.022305773571133614, -0.002858399413526058, -0.011320442892611027, -0.00993371568620205, -0.004754597786813974, 0.016857746988534927, 0.01171537023037672, -0.004053999204188585, 0.015113379806280136, 0.02304106205701828, -0.0249139666557312, -0.011819768697023392, -0.00020777666941285133, -0.013796514831483364, -0.011641694232821465, -0.01605892926454544, -0.0032422784715890884, 0.040852829813957214, -0.01885654404759407, -0.0036118575371801853, 0.002544959308579564, -0.008050348609685898, -0.003465312998741865, -0.022687524557113647, -0.044187031686306, 0.002490875544026494, 0.0259566493332386, 0.0033140636514872313, -0.016743455082178116, -0.017755605280399323, -0.012428101152181625, 0.0052469223737716675, 0.006700798869132996, -0.012867114506661892, -0.024622533470392227, 0.024980098009109497, 0.010784203186631203, -0.010497701354324818, 0.011707705445587635, -0.021188512444496155, 0.0007966305129230022, -0.017668209969997406, -0.013031933456659317, -0.01134081557393074, 0.011203310452401638, 0.009580396115779877, 0.004918673075735569, 0.016967419534921646, -0.0044714780524373055, 0.008752880617976189, 0.031278155744075775, -0.008590755984187126, 0.017539910972118378, 0.014819107949733734, 0.004836970008909702, -0.016582323238253593, -0.024785414338111877, 0.07217162847518921, 0.008165018633008003, 0.008072488009929657, -0.013100323267281055, -0.001280525466427207, -0.016128141433000565, -0.008423407562077045, 0.000688817584887147, -0.008289571851491928, 0.003901917487382889, 0.012294507585465908, 0.005857901647686958, 0.014983851462602615, 0.0192934088408947, -0.02091233804821968, -0.01865827664732933, 0.02051287516951561, -0.038687027990818024, 0.039834003895521164, 0.0014386004768311977, 0.028903678059577942, -0.029760321602225304, -0.006127686705440283, -0.018987340852618217, 0.03508920222520828, -0.024692349135875702, 0.017954833805561066, -0.0118733961135149, 0.004285134375095367, 0.009689162485301495, 0.021206773817539215, -0.01271260529756546, -0.0008949360344558954, 0.0024335230700671673, 0.04055182635784149, 0.01665181666612625, 0.00955002661794424, -0.006350000388920307, -0.003249384695664048, -0.0037260595709085464, 0.0051176357083022594, -0.009516199119389057, 0.010968307964503765, 0.008488441817462444, -0.01620647870004177, -0.01861797273159027, 0.01401371881365776, -0.00434874976053834, -0.005534975789487362, -0.007222505286335945, -0.019666429609060287, 0.0010155965574085712, 0.019618727266788483, 0.015564952045679092, 0.00698013324290514, -0.036057885736227036, 0.025430822744965553, -0.00579336890950799, -0.01503656804561615, -0.02670898288488388, -0.010710583999752998, 0.02365330420434475, 0.021644961088895798, -0.02879437431693077, -0.01320711150765419, -0.021565424278378487, -0.003356723114848137, -0.027519812807440758, 0.013064820319414139, -0.0029095718637108803, 0.02373507060110569, -0.019155897200107574, -0.02716296911239624, 0.007191321346908808, -0.007066791877150536, -0.0022371942177414894, 0.009639524854719639, 0.002534290077164769, 0.019544117152690887, -0.002509299200028181, -0.0134954322129488, 0.00634404830634594, 0.002040635561570525, 0.00960520189255476, 0.00040650181472301483, -0.016239088028669357, -0.016699789091944695, -0.07440266013145447, 0.011456490494310856, 0.027529332786798477, -0.0088173383846879, -0.02006669156253338, 0.03241664916276932, -0.009890750050544739, 0.006430831737816334, -0.013672075234353542, 0.00577498646453023, 0.0077821328304708, 0.004695570096373558, -0.019763445481657982, 0.011797452345490456, 0.011339275166392326, 0.016352007165551186, 0.0003233887255191803, 0.019499626010656357, -0.0007170205935835838, -0.003976284526288509, 0.01558847539126873, -0.006308447103947401, -0.008848736993968487, 0.00908061396330595, -0.0018875082023441792, -0.08120556175708771, 0.010477114468812943, -0.005666394252330065, -0.01982547529041767, 0.009410602040588856, -0.02100037783384323, 0.02734946273267269, 0.006320990156382322, 0.02687293291091919, -0.01511801965534687, 0.010661330074071884, 0.0002453508786857128, -0.013080006465315819, 0.0016245697624981403, -0.014256060123443604, -0.006422625854611397, 0.009062293916940689, -0.031143348664045334, 0.005250901915132999, -0.0021995401475578547, -0.019840458407998085, -0.019543815404176712, -0.010665304958820343, -0.015613656491041183, -0.008543011732399464, -0.036593496799468994, 0.00005607947241514921, 0.015077690593898296, -0.015230009332299232, 0.014040191657841206, 0.013398470357060432, -0.005721652880311012, -0.005296973045915365, -0.031005823984742165, 0.002615443430840969, -0.00513867475092411, -0.009235192090272903, -0.004145808983594179, -0.00208971556276083, 0.007758572697639465, -0.0007224952569231391, 0.0069036041386425495, -0.006469015963375568, -0.0005461984546855092, -0.00938221625983715, -0.0024311142042279243, 0.005211012437939644, -0.0026895208284258842, 0.0019008908420801163, 0.010276135057210922, 0.014005963690578938, -0.0035430900752544403, -0.01127494964748621, -0.023158371448516846, -0.022167202085256577, 0.031976163387298584, -0.005605995189398527, 0.028861984610557556, 0.04279313236474991, 0.005237520672380924, 0.004485087934881449, 0.033552270382642746, -0.004161194898188114, 0.07176309823989868, -0.025999141857028008, -0.00232457322999835, -0.0151778319850564, -0.007209730334579945, 0.00024554773699492216, -0.02964681386947632, -0.011061085388064384, 0.0019892998971045017, -0.009468619711697102, 0.011440235190093517, 0.003009953536093235, 0.017401129007339478, 0.010468666441738605, 0.028094999492168427, 0.017745083197951317, 0.015724213793873787, -0.002148791216313839, -0.029000844806432724, -0.0034732969943434, 0.0005047681042924523, 0.03414130583405495, -0.023512208834290504, -0.01606099121272564, -0.02169974148273468, 0.000985588994808495, -0.010883556678891182, -0.02763022482395172, 0.004502799361944199, -0.02864791452884674, -0.021549321711063385, -0.014088699594140053, -0.006269969046115875, -0.0225085262209177, 0.033726766705513, 0.026202034205198288, -0.00863711815327406, 0.0033533417154103518, 0.00696776807308197, 0.01609928533434868, -0.03811337798833847, 0.01670152321457863, -0.0031148327980190516, 0.0018336349166929722, 0.0371597483754158, -0.0382535457611084, 0.0031138379126787186, 0.011995550245046616, 0.005789116956293583, 0.002996666356921196, 0.029248129576444626, -0.005882604978978634, -0.0003961818292737007, 0.012666350230574608, 0.012531720101833344, 0.004030147567391396, -0.0075767068192362785, 0.026061078533530235, -0.012839095667004585, -0.01820935122668743, 0.0015281857922673225, -0.01829991117119789, -0.03308805823326111, -0.010349341668188572, -0.0031883709598332644, -0.014676772989332676, -0.0027102066669613123, -0.018953640013933182, -0.007668949197977781, 0.01723577082157135, -0.005651661194860935, 0.011242924258112907, 0.00020748976385220885, 0.008185172453522682, 0.012719320133328438, -0.01818348467350006, 0.007796000223606825, -0.002929900772869587, 0.007942999713122845, -0.0010538948699831963, -0.003185797482728958, 0.013407438062131405, 0.02615785412490368, 0.005227226763963699, 0.0065887700766325, 0.0003099245950579643, -0.02948816306889057, 0.018060414120554924, -0.00059786147903651, 0.004766940139234066, -0.0012270212173461914, -0.004678660538047552, -0.0027484954334795475, -0.004147019237279892, 0.007334292400628328, 0.03432897478342056, 0.012990712188184261, 0.002454647095873952, -0.0015652828151360154, 0.018890682607889175, 0.009415833279490471, 0.023594561964273453, -0.007600593846291304, -0.050729259848594666, -0.008490358479321003, -0.011065676808357239, -0.0007475810125470161, 0.02020055614411831, -0.008495979011058807, 0.00950195174664259, 0.011965947225689888, 0.018240807577967644, 0.017064789310097694, -0.0027084331959486008, -0.011605946347117424, -0.007877722382545471, -0.005720240995287895, 0.0016886251978576183, -0.01240776851773262, -0.011954020708799362, -0.014683734625577927, 0.00866101123392582, -0.0030893313232809305, 0.014093417674303055, -0.021210305392742157, -0.02045699767768383, -0.01357339322566986, 0.009645788930356503, -0.000807106785941869, 0.021291246637701988, 0.013757862150669098, -0.020466361194849014, 0.005001498386263847, 0.02034952864050865, -0.006957532837986946, 0.0011554595548659563, 0.00687751779332757, 0.002159783383831382, 0.018558740615844727, 0.002440220443531871, 0.009535147808492184, -0.0026939422823488712, -0.0007934320019558072, 0.010031618177890778, 0.008114737458527088, -0.007621064782142639, 0.01582796685397625, 0.023476380854845047, 0.005188926123082638, -0.024004504084587097, -0.008741792291402817, 0.002440714044496417, 0.004130181856453419, -0.006164082325994968, 0.025958813726902008, 0.019636135548353195, 0.012094560079276562, -0.01204582117497921, 0.003834674134850502, 0.013883969746530056, 0.012380395084619522, 0.00028702523559331894, -0.021671878173947334, 0.018960386514663696, 0.010549826547503471, 0.018977440893650055, 0.013376892544329166, 0.005830187350511551, -0.006180203519761562, 0.021564936265349388, -0.004400085657835007, 0.007479819469153881, -0.008588949218392372, 0.00200130557641387, -0.018354889005422592, -0.014548939652740955, -0.030962102115154266, 0.002282647415995598, -0.0024788484442979097, 0.001654977211728692, 0.012052467092871666, -0.05660676956176758, 0.006698012351989746, -0.00486349081620574, -0.009993629530072212, -0.0034419004805386066, 0.0002806995762512088, 0.012461542151868343, 0.007900875061750412, 0.0027671880088746548, -0.012739286758005619, -0.030258329585194588, -0.011931058950722218, 0.030526533722877502, -0.02437000162899494, -0.019874170422554016, 0.02646738290786743, -0.03238785266876221, 0.01874474063515663, 0.014870635233819485, 0.019443387165665627, -0.018959891051054 ]
[ 0.17526210844516754, -0.040303315967321396, 0.0626949742436409, 0.028724707663059235, 0.09614286571741104, 0.0996566042304039, 0.04055672883987427, -0.4420841634273529, 0.040230393409729004, -0.3864677846431732, -0.0813731849193573, 0.47045838832855225, -0.1646323800086975, 0.3958785831928253, -0.3476073145866394, 0.5425795912742615, 0.3010849356651306, 0.18758954107761383, -0.12033513933420181, -0.45153898000717163, -0.6547922492027283, -0.13421155512332916, 0.24202992022037506, 0.12949250638484955, -0.22460931539535522, 0.3712245523929596, 0.55178302526474, -0.33292070031166077, -0.4841296970844269, -0.20638422667980194, 0.24060386419296265, -0.2485828399658203, -0.16559238731861115, -0.20410066843032837, -0.05614619329571724, 0.026575561612844467, -0.28792014718055725, -0.401767760515213, -0.26110556721687317, -0.4899143874645233, -0.2979654371738434, -0.08768371492624283, -0.07953018695116043, 0.41992947459220886, -0.24499888718128204, -0.33131375908851624, -1.419633388519287, 0.1521766185760498, -0.43189263343811035, -0.04267645254731178, -0.26192131638526917, -0.3966127634048462, 0.03352225944399834, 0.37006840109825134, 0.29311129450798035, 0.3210754990577698, -0.617035984992981, -0.29868701100349426, 0.2590121030807495, -0.6894147992134094, -0.1503133773803711, -0.15725331008434296, -0.37632647156715393, 0.3068128228187561, -0.11213155835866928, 0.3619880676269531, 0.33637136220932007, -0.6205228567123413, -0.8407964110374451, -0.7632735967636108, 0.3174964487552643, -0.5516766905784607, 0.0407191626727581, 0.5759304761886597, -0.2765684425830841, -0.3005431592464447, -0.024622052907943726, -0.26632800698280334, 0.2537696957588196, 0.0804152563214302, -0.12252089381217957, 0.004103431012481451, 0.025075355544686317, -0.17255164682865143, 0.5652748346328735, 0.3831709921360016, 0.19151820242404938, 0.6609590649604797, -0.4913574755191803, 0.0869784727692604, -0.27511030435562134, -0.5307751297950745, 0.09450653195381165, 0.5199860334396362, 0.6636027693748474, 0.31880542635917664, 0.5354998707771301, -0.20063725113868713, 0.28797078132629395, 0.32105788588523865, -0.266235888004303, -0.07398492097854614, 0.18694932758808136, -0.37735429406166077, -0.7010688185691833, -0.6393886208534241, -0.3829149901866913, -0.4526323974132538, -0.5399138927459717, 0.15850621461868286, -0.7671206593513489, 0.22830642759799957, -0.1308717280626297, 0.07708793878555298, -0.503382682800293, 0.501147449016571, -0.12276407331228256, 0.16100841760635376, -0.04044694826006889, 0.5363501310348511, 0.2563333511352539, 1.7473349571228027, -0.1415753960609436, 0.4261702001094818, -0.1686410903930664, 0.011529636569321156, 0.6799231767654419, 0.6550461053848267, -0.6608142852783203, 0.3212132751941681, 0.052285246551036835, 0.8619304895401001, -0.16575416922569275, 0.17759990692138672, -0.07245158404111862, -0.4414551556110382, 0.5817996263504028, -0.021503213793039322, 0.3764500617980957, -0.16804726421833038, -0.6784626245498657, -0.778308093547821, 0.06447704136371613, -0.20103517174720764, 0.07661309838294983, -0.47979384660720825, 0.08987629413604736, 0.06899235397577286, 0.15701806545257568, -0.272227019071579, -0.05159072205424309, -0.07023349404335022, -0.5158824324607849, -0.39438894391059875, -0.21942052245140076, 0.5962622761726379, -0.23910272121429443, -0.18272532522678375, 0.24077057838439941, 0.0932379886507988, 0.0521932952105999, 0.18325169384479523, -0.43600994348526, -0.13285048305988312, 0.291367769241333, -0.2558028995990753, 0.609429121017456, 0.6359162926673889, -0.006012053228914738, -0.13057251274585724, -0.44042280316352844, -0.299098938703537, -0.11793366074562073, -0.6573285460472107, -0.1818164736032486, 0.07881952077150345, 0.4876147210597992, 0.29339176416397095, -0.02812931314110756, -0.039532002061605453, -0.8720448017120361, 0.43952879309654236, -0.03738165646791458, -0.6879469752311707, -0.09982099384069443, 0.1913057565689087, 0.49137985706329346, -0.17744174599647522, -0.19885504245758057, 0.3026507794857025, -0.24701857566833496, 0.11140882223844528, 0.5932834148406982, -1.3193891048431396, 1.3870054483413696, -0.01437442097812891, -0.05687349662184715, 1.73710036277771, -0.6010999083518982, 0.20828595757484436, -0.24257850646972656, 0.2766408324241638, 0.6467419862747192, -0.2451947033405304, -0.4775505065917969, -0.3784838318824768, 0.028294270858168602, 0.06955738365650177, 0.27902722358703613, 0.06853749603033066, 0.6649764776229858, 0.0749078243970871, -0.039087072014808655, 0.32120323181152344, 0.09020284563302994, 0.2562215030193329, -0.2575890123844147, -0.2591560482978821, -0.3455909490585327, -0.2534233331680298, 0.38854607939720154, -0.4941045045852661, 0.2742702066898346, 1.0970226526260376, 0.13218338787555695, 0.6364662051200867, 0.5487499833106995, -0.05878450721502304, 0.8642282485961914, 0.05344057455658913, 0.23674143850803375, -0.1002241000533104, 0.07242321223020554, -0.45901793241500854, -0.30474409461021423, 0.2115381360054016, 0.5397266149520874, -0.477674275636673, -0.1473601907491684, 0.12149237096309662, 0.043283455073833466, 0.12220333516597748, -0.2695547342300415, 0.040669459849596024, 0.2643239498138428, -0.03625306859612465, -0.4228653013706207, 0.38809797167778015, -0.25301843881607056, -0.3775458037853241, 0.0036869130562990904, 0.5570365786552429, 0.23410774767398834, -0.6016838550567627, 0.3678373694419861, 0.0013988990103825927, -0.5884556174278259, -0.1642761081457138, -0.10110088437795639, -0.2646653354167938, 0.33087486028671265, 0.27662649750709534, -0.0363190583884716, 0.09994726628065109, 0.06918050348758698, -0.4271920621395111, -0.5540968179702759, -0.08230126649141312, 1.0251082181930542, 0.5840996503829956, 0.1214139461517334, -0.12840600311756134, -0.6077746748924255, 0.2241452932357788, -0.2703452408313751, -0.44149118661880493, -0.4774645268917084, 0.2864891290664673, -0.5349588990211487, -0.2511008083820343, -0.11457246541976929, 0.4037229120731354, 0.5360568165779114, -0.17136713862419128, -0.37353911995887756, 0.09501805901527405, 0.16827405989170074, -0.37017133831977844, -0.40522703528404236, 0.38900646567344666, -0.18814602494239807, 0.07077330350875854, -0.10995692014694214, -0.1491113305091858, 0.5019598603248596, -0.28493794798851013, 0.009261776693165302, -0.09743228554725647, 0.2658446431159973, 0.17545858025550842, -0.13814303278923035, 0.08803369849920273, -0.028324658051133156, -0.03670750930905342, -0.3776785135269165, -0.34659603238105774, -0.27613070607185364, 0.2384595274925232, -5.876152038574219, -0.1124216690659523, -0.07281352579593658, 0.11149697750806808, -0.22216796875, -0.26823142170906067, 0.3995387852191925, 0.03141893073916435, 0.06977104395627975, -0.0552167072892189, 0.37339937686920166, 0.7336620688438416, 0.11344017088413239, 0.09572295099496841, -0.2513764500617981, 0.1416899710893631, 0.2048550844192505, 0.10017185658216476, 0.43739092350006104, 0.16864533722400665, 0.07700303941965103, -0.24949900805950165, -0.11424557119607925, 0.9872942566871643, -0.05689648911356926, 0.36500218510627747, -1.00554621219635, 0.06677156686782837, -0.36214926838874817, -0.576555073261261, -0.07934418320655823, -0.10693801939487457, 0.2608594298362732, -0.1765526831150055, 0.15600073337554932, 0.5149107575416565, 0.08298696577548981, 0.02331189066171646, 0.13062797486782074, -0.5975608825683594, 0.7834643125534058, 0.22095735371112823, -0.077960304915905, -0.18578536808490753, -0.03083891235291958, -0.08356410264968872, -0.428698867559433, 0.5121950507164001, -0.05638611316680908, 0.9260179996490479, -0.11414867639541626, -0.42454686760902405, 0.6586257815361023, 0.5231276750564575, 0.27375465631484985, -0.43481573462486267, -0.16805234551429749, -0.14422617852687836, -0.5573562979698181, 0.7236381769180298, -0.3201152980327606, -0.2796243727207184, -0.22959132492542267, -0.593085765838623, -0.1435813009738922, 0.20811647176742554, -0.8045628666877747, -0.6389474272727966, 0.27207425236701965, 0.1423880010843277, -0.679794192314148, 0.6575208306312561, 0.6280152201652527, -0.4075348973274231, 0.478400319814682, -0.3031977713108063, 0.03521571680903435, -0.03318074345588684, -0.23242191970348358, 0.3273155391216278, 0.09157576411962509, -0.4292113780975342, 0.2002331167459488, -0.3128149211406708, 0.058063630014657974, -0.40569350123405457, -0.4024905860424042, 0.0846441388130188, -0.166212260723114, 0.5620507597923279, 0.48113390803337097, -0.01722876727581024, 0.033814724534749985, 0.2912524342536926, 0.533008873462677, 0.17030543088912964, 0.40535616874694824, 0.46091848611831665, 0.35643231868743896, -0.4617335796356201, 0.6461386680603027, 0.5352494120597839, -0.2561858892440796, -0.8852543234825134, 0.02996215969324112, -0.2895946502685547, -0.5614655017852783, 0.04534045234322548, 0.1885181963443756, -0.5864541530609131, -0.1154092401266098, -0.30186235904693604, -0.6405216455459595, -0.30848902463912964, 0.4547422528266907, 0.13116739690303802, -0.2583552300930023, -0.10092615336179733, 0.6007031202316284, -0.1932162046432495, 0.5296948552131653, 0.031066356226801872, -0.46456286311149597, 0.4975350797176361, 0.337750107049942, -0.18048110604286194, 0.04619889333844185, 1.184518575668335, -0.41780972480773926, -0.12042345851659775, 0.4018343389034271, 0.47491565346717834, -0.8744044303894043, 0.1099276915192604, 0.007006397005170584, -0.16423289477825165, -0.21770469844341278, 0.2642902731895447, -0.3103674650192261, -0.3781375586986542, 0.5760546922683716, -0.3888610303401947, -0.03446543589234352, 0.27986398339271545, -0.05627787485718727, -0.09542053937911987, -0.4121174216270447, 0.03474070504307747, -0.13450710475444794, -0.11517343670129776, 0.228000208735466, -0.55363529920578, 0.37950921058654785, -0.2397049218416214, 0.10322960466146469, 0.276108980178833, 0.4464629292488098, 0.27687448263168335, 0.390190064907074, -0.663078248500824, 0.3255361318588257, 0.1281159669160843, -0.43472152948379517, 0.18407604098320007, -0.30243241786956787, 0.1080331951379776, -0.18121437728405, -0.2739284038543701, -0.08829789608716965, 0.2637057602405548, -0.25617149472236633, -0.607795774936676, -0.64630526304245, -0.4773096740245819, 0.53399658203125, -0.034256577491760254, -0.03437379002571106, 0.5794501900672913, 0.08995012193918228, -0.22011138498783112, 0.172807976603508, -0.8825526237487793, -0.08912618458271027, -0.04846565052866936, 0.9378231763839722, -0.058330975472927094, 0.06688198447227478, -0.48053595423698425, -0.48031359910964966, -0.3107563257217407, 0.26704370975494385, 0.8490409255027771, 0.23500506579875946, -0.04429485276341438, -0.13349273800849915, -0.6224031448364258, -0.002422842662781477, 0.5392559170722961, 0.28889328241348267, -0.47333353757858276, 0.5898898243904114, 0.5788576006889343, -0.15861041843891144, 0.4376371204853058, 0.8139633536338806, -0.2620486617088318, -0.273254930973053, 0.27905353903770447, -0.2702902853488922, -0.1522618532180786, -0.1696036458015442, -0.6035550832748413, 0.12130501866340637, 0.08757789433002472, -0.24669890105724335, 0.047759655863046646, -0.043698109686374664, -0.24241545796394348, -0.4112379252910614, 0.6562802791595459, 0.19726859033107758, -0.2953837215900421, -0.2864374816417694, 0.2244412750005722, -0.4772557318210602, -0.08180346339941025, 0.33076712489128113, -0.9908430576324463, -0.26290521025657654, 0.12106366455554962, -0.13091504573822021, -0.10095956921577454, -0.017918113619089127, -0.226360023021698, 0.007880429737269878, -0.17871035635471344, 0.33538323640823364, 0.6968927979469299, -0.24248720705509186, -0.0829419270157814, 0.5982134938240051, 0.5312984585762024, -0.2943241000175476, -0.19099047780036926, 0.02709936536848545, 0.5841627717018127, 0.034049395471811295, -0.8421223759651184, -0.8726661801338196, 0.23677530884742737, 0.24518156051635742, -0.25496241450309753, 0.47429534792900085, 0.32004788517951965, 0.8071045279502869, -0.002013235120102763, -0.07493477314710617, -0.3876374661922455, 0.09457752108573914, 0.36941254138946533, -0.012500226497650146, -0.14341400563716888, -0.1365147978067398, -0.4857192039489746, 0.6592706441879272, 0.14256978034973145, -0.07089211791753769, -0.5688894987106323, 0.23125942051410675, -0.22934377193450928, 0.36741724610328674, -0.10220489650964737, 0.5560808777809143, 0.6617429852485657, 0.23064789175987244, 0.1629887819290161, -0.2145472913980484, 0.3674089014530182, -0.5271713137626648, 0.052430447190999985, 0.06822886317968369, -0.5750716924667358, 0.24904020130634308, -0.381159245967865, 0.6021928191184998, -0.10575129091739655, 0.36777180433273315, -0.4284684658050537, 0.4255858361721039, -0.3051520884037018, -0.11572350561618805, 0.18178555369377136, -0.14077529311180115, -0.10908007621765137, -0.31216350197792053, 0.47659364342689514, -0.004199679009616375, 0.34902599453926086, -0.39640089869499207, -0.41594430804252625, 0.4015696346759796, 0.5146207213401794, 0.04420018568634987, -0.7254077792167664, -0.31876808404922485, 0.41876664757728577, 0.7435183525085449, 0.06968428194522858, -0.5591290593147278, 0.10549194365739822, 0.27205073833465576, -0.17782916128635406, 0.2746272385120392, 0.09498444199562073, 0.015434998087584972, 0.35148581862449646, 0.06709655374288559, -0.2537347376346588, 0.5385793447494507, 0.17400123178958893, 0.12780176103115082, 0.6612312197685242, 0.4845796823501587, -0.4466017186641693, -0.33687540888786316, 0.23590931296348572, -0.14728854596614838, 0.1593342423439026, -0.031039638444781303, -0.2523399889469147, 0.5378936529159546, 0.6837649345397949, -0.3165072500705719, 0.503899872303009, 0.3574289083480835, -0.005803131964057684, 0.21664322912693024, -0.00010934281453955919, -0.143484964966774, 0.08892469108104706, 0.35772618651390076, 0.4507029354572296, -0.4171398878097534, -0.31574222445487976, 0.0735740214586258, 0.2671148180961609, 0.2799129784107208, 0.41898253560066223, -0.14414019882678986, 0.2708045244216919, 0.1462339162826538, -0.24588291347026825, -0.36313384771347046, 0.6024318933486938, -0.1700652539730072, -0.6312503814697266, 0.4460943043231964, -0.6719946265220642, 0.11674153059720993, 0.1427692323923111, -0.27500349283218384, 0.26006433367729187, -0.5746086239814758, 0.07397442311048508, 0.03799744322896004, -0.16274791955947876, 0.7116840481758118, -0.03416632488369942, 0.009518271312117577, -0.12887483835220337, 0.09143855422735214, 0.2718174457550049, 0.090792715549469, -0.10258683562278748, 0.24798980355262756, -0.34879979491233826, 0.030225355178117752, -0.008259927853941917, -0.3424919843673706, 0.35021480917930603, -0.2072126865386963, 0.06749390810728073, 0.12205233424901962, -0.3877643346786499, 0.003748357994481921, -0.1272726058959961, -0.22417587041854858, 0.018488764762878418, 0.13656160235404968, 0.0688626766204834, 0.3914279043674469, -0.9410801529884338, -0.3234195411205292, 0.27771344780921936, -0.05197790637612343, 0.004586037248373032, 0.1652216911315918, 0.39730706810951233, 0.30545756220817566, 0.20263707637786865, -0.1460326910018921, 0.634836733341217, 0.08232574909925461, 0.4497477114200592, -0.7083796858787537, 0.27233508229255676, -0.9312872886657715, -0.19609840214252472, -0.7282547950744629, 0.08612663298845291, 0.4957437515258789, 0.050952695310115814, -0.5716344118118286, -0.20927774906158447, 0.03570924326777458, 0.15836632251739502, -0.03598697483539581, -0.13641126453876495, -0.053081732243299484, -0.3574816584587097, 0.02174799144268036, 0.08032895624637604, 0.6377983689308167, -0.18365778028964996, -0.09038082510232925, -0.34597665071487427, 0.26559537649154663, 0.21000055968761444, -0.49170970916748047, 0.4795049726963043, 0.04216991737484932, 0.02316257171332836, -0.5231845378875732, 0.1593337059020996, -0.4318823218345642, -0.4217183589935303, -0.2006089687347412, 0.07581295818090439, 0.34108766913414, -0.37010452151298523, -0.09902948141098022, -0.029524249956011772, 0.4401433765888214, 0.3456914722919464, -0.05166039988398552, 0.037521153688430786, -0.12515614926815033, -0.5393070578575134, -0.5481216907501221, 0.4790138006210327, -0.050621919333934784, 0.2220003604888916, 0.1715840846300125, -0.14846991002559662, -0.110136978328228, 0.35246795415878296, -0.1954120546579361, -0.5085552930831909, -0.5995841026306152, 0.11827223747968674 ]
We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of masked words was observed in multiple cortical areas, mostly within an early time window (<300 ms), accompanied by induced gamma-band activity, but without coherent long-distance neural activity, suggesting a quickly dissipating feedforward wave. In contrast, conscious processing of unmasked words was characterized by the convergence of four distinct neurophysiological markers: sustained voltage changes, particularly in prefrontal cortex, large increases in spectral power in the gamma band, increases in long-distance phase synchrony in the beta range, and increases in long-range Granger causality. We argue that all of those measures provide distinct windows into the same distributed state of conscious processing. These results have a direct impact on current theoretical discussions concerning the neural correlates of conscious access.
[ -0.0019476362504065037, 0.004493197426199913, -0.005836735479533672, 0.024170950055122375, -0.01460426114499569, -0.03375587612390518, 0.012272985652089119, -0.017323121428489685, -0.012985143810510635, 0.05856209993362427, -0.011668482795357704, 0.014926274307072163, 0.021206701174378395, 0.02043524757027626, -0.03150531277060509, 0.037959035485982895, -0.017942048609256744, 0.026023246347904205, -0.0027399661485105753, 0.03513889014720917, 0.011260421946644783, -0.01494195032864809, 0.011189274489879608, 0.009355030953884125, -0.0013549099676311016, 0.0008029700256884098, -0.0063707767985761166, -0.03102308325469494, -0.013769842684268951, 0.013338974677026272, 0.014685354195535183, 0.004348139278590679, 0.0087149478495121, 0.005445299670100212, 0.01375200878828764, -0.008123883977532387, -0.006650386843830347, 0.017965342849493027, -0.016537083312869072, -0.0043218666687607765, 0.000118655851110816, -0.010920422151684761, 0.01013141218572855, 0.000554407830350101, -0.011513846926391125, -0.005358261056244373, -0.006007605232298374, 0.0012938017025589943, -0.006222642492502928, 0.0059547703713178635, -0.0034461566247045994, 0.0046968841925263405, -0.010737426578998566, -0.0013425746001303196, -0.007821673527359962, 0.01351272314786911, 0.022170724347233772, 0.027879592031240463, -0.013491539284586906, -0.005505246110260487, -0.019734952598810196, 0.01637834496796131, 0.020944979041814804, -0.007925931364297867, -0.04068442061543465, -0.06608299911022186, 0.020694322884082794, -0.02743450552225113, -0.0040182736702263355, -0.02376161888241768, 0.009729024022817612, 0.007050652056932449, -0.025107238441705704, 0.04585440829396248, 0.04265521466732025, -0.015880335122346878, -0.017146345227956772, 0.021493222564458847, -0.03188100457191467, -0.0018597213784232736, -0.030850231647491455, -0.011781432665884495, -0.02777528204023838, 0.006859040819108486, -0.0011575397802516818, -0.028007980436086655, -0.017580322921276093, 0.023502901196479797, -0.000003059394657611847, -0.005388898774981499, 0.017844824120402336, 0.019430574029684067, -0.01271970383822918, 0.014415282756090164, 0.008474217727780342, 0.03286980837583542, 0.03235737606883049, 0.0026114073116332293, -0.01438971608877182, 0.02027866430580616, -0.021858112886548042, 0.01398727111518383, 0.036879293620586395, 0.009283632040023804, -0.013603486120700836, 0.006374740041792393, -0.0002948481123894453, -0.00409969687461853, 0.01751694083213806, 0.006250455975532532, 0.020051078870892525, 0.013269692659378052, 0.020299091935157776, 0.013355650007724762, 0.005143065936863422, -0.001064022653736174, 0.010051349177956581, 0.02517903968691826, 0.0054784975945949554, -0.0031804197933524847, -0.005266428925096989, 0.009786451235413551, 0.003883624915033579, -0.011420484632253647, 0.007304839324206114, 0.007278695702552795, -0.02828143537044525, 0.012261521071195602, 0.029701363295316696, -0.006403641775250435, -0.011190502904355526, 0.00010902492795139551, 0.020143844187259674, 0.02186143584549427, 0.015269075520336628, -0.008072929456830025, -0.004481465555727482, -0.03400353714823723, 0.022304203361272812, 0.016760047525167465, 0.006272190250456333, 0.010581519454717636, 0.005028550513088703, 0.02050742879509926, 0.018800776451826096, 0.007810569368302822, 0.002356455661356449, 0.00713062658905983, -0.001777126919478178, -0.04163843020796776, -0.004467078484594822, -0.0011045574210584164, 0.016249772161245346, -0.01784149743616581, -0.009265810251235962, -0.003470886964350939, -0.044475264847278595, 0.020841289311647415, -0.009056971408426762, -0.034404776990413666, -0.0012543047778308392, 0.018870973959565163, 0.013653513044118881, 0.009245920926332474, -0.005844477564096451, -0.00677748117595911, 0.008059011772274971, 0.0076858652755618095, 0.0030215575825423002, 0.002267521107569337, 0.012984203174710274, -0.0014040665701031685, -0.04247400909662247, 0.013146614655852318, 0.008306837640702724, -0.013321461156010628, 0.021581578999757767, 0.003601204603910446, -0.009514238685369492, 0.06676729023456573, -0.038028229027986526, -0.008887195959687233, 0.016261041164398193, 0.00026007648557424545, -0.010785139165818691, -0.006751720793545246, -0.0116420304402709, 0.0035399787593632936, 0.019149411469697952, -0.004306248389184475, -0.009486081078648567, -0.015088429674506187, 0.02763436734676361, -0.026874618604779243, 0.023138221353292465, 0.004251163452863693, -0.009136166423559189, 0.007945239543914795, -0.023630335927009583, -0.014355843886733055, 0.020654277876019478, -0.009308060631155968, -0.020102152600884438, 0.010011442005634308, -0.005386250093579292, -0.0016321138245984912, 0.03669078275561333, -0.0323554202914238, 0.01151659619063139, 0.004985991399735212, 0.017974596470594406, 0.025544121861457825, -0.013007833622395992, -0.024176884442567825, 0.008629295974969864, -0.022015433758497238, -0.006812135688960552, 0.030264556407928467, 0.01665400341153145, -0.016642633825540543, 0.0023530719336122274, 0.005095561966300011, 0.014373661950230598, 0.0022672838531434536, -0.006931214593350887, 0.0042756302282214165, -0.004871194716542959, 0.009610293433070183, 0.01106388308107853, 0.007922914810478687, -0.02388036623597145, 0.007765297777950764, -0.01074626948684454, -0.013605406507849693, 0.03560370206832886, -0.004503454081714153, 0.01398002915084362, -0.017262669280171394, 0.008456908166408539, -0.012409382499754429, -0.006416065618395805, -0.017157360911369324, 0.02128782495856285, -0.05570616573095322, 0.007866289466619492, -0.015983549878001213, 0.006298896856606007, 0.023654788732528687, -0.030104462057352066, 0.004693443421274424, 0.011896857060492039, -0.009783489629626274, 0.008901577442884445, -0.004659896716475487, 0.03939041122794151, -0.03379727154970169, -0.012221520766615868, -0.0018277713097631931, 0.02699080854654312, 0.0075522237457334995, 0.005209923721849918, 0.00940266065299511, 0.00761994905769825, 0.008959916420280933, -0.02996363304555416, 0.013488030061125755, 0.04353151470422745, -0.0032848103437572718, -0.004315818659961224, 0.006443632300943136, 0.006483722478151321, -0.020985737442970276, -0.0025749816559255123, -0.0807318240404129, -0.0044065192341804504, 0.014351327903568745, 0.04990098252892494, 0.007276070304214954, 0.014066370204091072, 0.013288192451000214, 0.013294180855154991, -0.019149741157889366, -0.011010831221938133, 0.003657079767435789, 0.00644948985427618, -0.01053597591817379, 0.00851811096072197, -0.0005333016160875559, -0.006576545536518097, 0.019712157547473907, 0.011422506533563137, -0.007920335046947002, 0.008580191992223263, 0.004193332977592945, 0.025658391416072845, 0.04221147298812866, -0.010241083800792694, -0.009324956685304642, 0.028366439044475555, -0.029598230496048927, -0.009450901299715042, 0.0036819549277424812, 0.004038871265947819, -0.01134522445499897, -0.013223826885223389, -0.010159497149288654, -0.007382431998848915, 0.007007836364209652, -0.009005718864500523, -0.009284504689276218, 0.010705674067139626, -0.012514717876911163, 0.03125590458512306, 0.012941474094986916, 0.00573018379509449, -0.004503030329942703, -0.002868611365556717, 0.0019755461253225803, 0.008734595961868763, -0.01261047087609768, -0.01704699918627739, 0.02381318062543869, -0.001745154382660985, 0.01987222209572792, 0.003033546730875969, -0.01897112838923931, 0.014166576787829399, -0.008428606204688549, 0.006922082044184208, -0.018127063289284706, 0.010222336277365685, -0.00014003063552081585, 0.0037024635821580887, 0.00959550216794014, 0.01543343998491764, -0.012291131541132927, -0.006128295324742794, 0.008039025589823723, 0.005820444785058498, 0.019412875175476074, -0.00376405892893672, 0.005220899824053049, -0.00011539552360773087, -0.002688484499230981, 0.007438714616000652, -0.011432555504143238, 0.003844901919364929, 0.011868918314576149, -0.01339932344853878, -0.015208898112177849, -0.01831565797328949, -0.016766952350735664, -0.03689918667078018, -0.011732960119843483, 0.02925882861018181, 0.013239982537925243, 0.0005845824489369988, -0.02862338349223137, -0.017129968851804733, 0.0037111027631908655, 0.01662016659975052, 0.02744916081428528, -0.01684664934873581, -0.003618753980845213, 0.03272666409611702, 0.012292163446545601, 0.011156827211380005, 0.006536598317325115, -0.03700312227010727, -0.015158954076468945, -0.0025090519338846207, -0.01471724547445774, 0.012253746390342712, -0.03081488609313965, -0.003892952110618353, -0.008761608973145485, -0.016881093382835388, -0.00018612947314977646, 0.008535528555512428, -0.0023377672769129276, -0.029129711911082268, 0.02029298059642315, -0.004967701621353626, 0.005119267851114273, -0.0039643594063818455, -0.007513066753745079, 0.007481331005692482, 0.01465819776058197, 0.014592341147363186, 0.003933062311261892, -0.03888557106256485, 0.07096630334854126, -0.006734468042850494, 0.012674636207520962, -0.01565893553197384, 0.022177424281835556, -0.00952061265707016, -0.009302026592195034, -0.01155747938901186, 0.0121788764372468, -0.017339834943413734, 0.015123056247830391, 0.02879903092980385, 0.036581702530384064, 0.04301998019218445, 0.019885027781128883, -0.009928234852850437, 0.00784594938158989, 0.010017448104918003, 0.01829914189875126, 0.03674658387899399, 0.01633949764072895, -0.002456757239997387, 0.020296402275562286, -0.006610773503780365, 0.010425989516079426, -0.010718096047639847, 0.02122277021408081, -0.02381642907857895, 0.0027330447919666767, 0.007704814895987511, -0.010941678658127785, -0.010613467544317245, -0.006711766589432955, 0.024981627240777016, 0.0003345254808664322, 0.01212001871317625, 0.00494288420304656, -0.009723152965307236, -0.021890707314014435, -0.01596996746957302, 0.0036136789713054895, -0.009734420105814934, 0.004362672101706266, 0.024271992966532707, -0.002677501179277897, -0.011751355603337288, 0.021394751965999603, -0.0005140815628692508, 0.0031501566991209984, 0.02192716859281063, -0.026480000466108322, 0.0102878762409091, 0.008422640152275562, -0.011088022962212563, -0.02605794370174408, -0.000631774659268558, 0.02697024866938591, -0.006836141925305128, -0.03207068145275116, -0.0032148906029760838, -0.04034522920846939, -0.04922211170196533, -0.016621477901935577, 0.011384142562747002, -0.030556457117199898, -0.013178071938455105, -0.030377939343452454, -0.005240198224782944, 0.0035061603412032127, 0.01215322595089674, -0.02430592104792595, 0.0038720660377293825, -0.016897035762667656, -0.012842927128076553, -0.02442895621061325, 0.011640539392828941, 0.006735530681908131, -0.011837618425488472, -0.01074665691703558, -0.007835752330720425, 0.019832229241728783, 0.005968048237264156, -0.006647699978202581, -0.01930372230708599, -0.017758209258317947, 0.016565995290875435, -0.039563924074172974, -0.07451760768890381, -0.0024325852282345295, 0.014724456705152988, -0.008827717043459415, 0.012482242658734322, 0.00015492457896471024, -0.0184878371655941, 0.012491511180996895, -0.02556392177939415, 0.0022203419357538223, -0.0073208436369895935, 0.015377693809568882, 0.015152398496866226, 0.00330225913785398, 0.012349448166787624, 0.005170716438442469, -0.02867250144481659, 0.011995179578661919, 0.010534417815506458, -0.0002600407460704446, -0.01913801208138466, -0.03197808563709259, 0.0059116738848388195, 0.002345637185499072, -0.005756877828389406, -0.07982297241687775, -0.01271209679543972, 0.013689631596207619, -0.01465432345867157, -0.03159434348344803, 0.018308836966753006, 0.0037024077028036118, -0.030438628047704697, -0.007627471815794706, -0.016559042036533356, 0.0003883214667439461, 0.031210806220769882, 0.028496410697698593, 0.005767321214079857, 0.0006731839384883642, -0.001984119415283203, 0.014679213985800743, -0.0003997897729277611, -0.005929757375270128, -0.02699170634150505, -0.00728974025696516, 0.015292830765247345, -0.0122373690828681, 0.010375875979661942, -0.007135160267353058, -0.013187913224101067, -0.01798441633582115, 0.012324661947786808, 0.020108047872781754, -0.04705966264009476, 0.00607023760676384, -0.00733653549104929, -0.020264308899641037, -0.010967988520860672, -0.007137990556657314, -0.029308898374438286, -0.04018687829375267, -0.00592390913516283, 0.018242498859763145, 0.009053598158061504, 0.002761597279459238, -0.021321889013051987, 0.02072771266102791, 0.021794090047478676, 0.008589796721935272, -0.012087445706129074, 0.003282932098954916, -0.01517433300614357, 0.027316918596625328, 0.017449017614126205, 0.007565581239759922, 0.020424533635377884, 0.049860887229442596, -0.014988383278250694, 0.01548878476023674, 0.008878765627741814, -0.0033725614193826914, 0.0332736074924469, 0.028952110558748245, 0.022374488413333893, -0.01511659100651741, 0.043916188180446625, -0.010437607765197754, 0.07160982489585876, 0.011517309583723545, 0.006356538739055395, -0.024950815364718437, 0.004169762600213289, -0.0018495363183319569, -0.00998895987868309, 0.019538186490535736, 0.025170763954520226, -0.011152940802276134, -0.006010669749230146, -0.009109965525567532, -0.011488011106848717, 0.013190307654440403, 0.018856549635529518, -0.01187673956155777, -0.008741922676563263, -0.012300836853682995, -0.02284897118806839, 0.03217591345310211, -0.023034261539578438, 0.030738933011889458, -0.027487514540553093, 0.005513349547982216, 0.01709098368883133, -0.014420121908187866, -0.00845456775277853, 0.0165675338357687, -0.010220389813184738, -0.012007062323391438, -0.012790285050868988, 0.008821101859211922, -0.0038260146975517273, -0.0443885363638401, 0.010877443477511406, -0.023326069116592407, -0.013118323870003223, 0.01505858451128006, -0.024165820330381393, 0.005082115530967712, -0.03272964805364609, -0.006501856260001659, 0.018396303057670593, -0.03317352384328842, -0.018863145262002945, -0.0015316775534301996, 0.031191349029541016, -0.019653350114822388, 0.02985353022813797, 0.014979615807533264, 0.003066526958718896, 0.004585470072925091, 0.014927530661225319, 0.005715411156415939, 0.026885278522968292, 0.0018333960324525833, -0.022173170000314713, 0.013442219235002995, -0.028783179819583893, 0.001219355734065175, 0.004987555555999279, -0.01943012699484825, -0.009852251969277859, -0.013809433206915855, 0.010882541537284851, -0.0035813874565064907, -0.0027490868233144283, -0.02706940844655037, -0.008077051490545273, 0.015221797861158848, 0.000057015568017959595, -0.03794611245393753, 0.007353787310421467, 0.00406989548355341, 0.019111966714262962, -0.0011029450688511133, -0.032537516206502914, 0.00835246592760086, 0.01112045906484127, 0.023834802210330963, -0.010448487475514412, -0.0069931382313370705, -0.037347592413425446, 0.04173598065972328, 0.004894431680440903, -0.011615972965955734, -0.040873706340789795, 0.01873311959207058, -0.0007988419383764267, 0.007578750140964985, 0.021883223205804825, 0.0017660517478361726, 0.004740361124277115, -0.002673789393156767, 0.007410974241793156, 0.0361783541738987, -0.00013284641318023205, -0.0003207210684195161, 0.004958698991686106, 0.0038032224401831627, 0.017216742038726807, 0.007935411296784878, -0.02028079703450203, 0.0032956672366708517, 0.0004691118374466896, -0.006103863008320332, 0.03421049937605858, -0.012095111422240734, 0.017942825332283974, -0.021530795842409134, 0.01876019313931465, -0.02944182977080345, 0.02699410729110241, 0.02662716805934906, 0.020992044359445572, -0.0014510632026940584, -0.008880632929503918, -0.03456550091505051, -0.014484847895801067, -0.009913228452205658, -0.051757581532001495, -0.02656698040664196, 0.008859456516802311, -0.011556419543921947, -0.001935502514243126, -0.046146489679813385, -0.013730497099459171, 0.012693658471107483, 0.01667831465601921, -0.0027732490561902523, 0.020137134939432144, 0.004114704206585884, 0.0259183868765831, 0.021968742832541466, 0.008207317441701889, 0.031305354088544846, 0.05163150280714035, -0.006952135358005762, -0.016258064657449722, -0.023270949721336365, 0.01330649759620428, -0.0020022904500365257, 0.008886661380529404, -0.008345933631062508, 0.008110851980745792, -0.03089793026447296, 0.025628168135881424, 0.02115500345826149, 0.011553395539522171, 0.003021635115146637, 0.0032086321152746677, 0.019400278106331825, 0.008428767323493958, -0.005341913551092148, -0.017227809876203537, 0.004659503698348999, -0.010577036999166012, -0.022848771885037422, -0.019393837079405785, 0.014690530486404896, 0.0004907622933387756, 0.007325734943151474, -0.026763414964079857, -0.02722575142979622, 0.008673220872879028, 0.04588143900036812, -0.003435250138863921, 0.0465298667550087, -0.026191726326942444, 0.0027424523141235113, 0.03370262682437897, -0.019622117280960083, -0.015621483325958252, 0.04532768577337265, -0.018210014328360558, -0.02266797237098217, 0.008279911242425442, 0.027033021673560143, 0.023082051426172256, 0.0007913499139249325, 0.0152961490675807, -0.015031655319035053, -0.0204011220484972, -0.015329236164689064, -0.0005295833107084036, 0.01947176083922386, 0.0011789783602580428, -0.010104232467710972, 0.0012054119724780321, 0.03967432677745819, -0.01398390345275402, -0.017902210354804993, -0.026076648384332657, -0.008314613252878189, 0.012510348111391068, -0.01725897192955017, -0.0062450747936964035, -0.006695583462715149, 0.016024822369217873, -0.018527880311012268, 0.027177313342690468, -0.01914019137620926 ]
[ -0.24773922562599182, -0.035241469740867615, 0.01051296852529049, 0.18755726516246796, -0.19302813708782196, 0.6240511536598206, 0.6729210615158081, -0.15493012964725494, 0.1847870796918869, -0.5862510800361633, 0.08141651004552841, 0.42996102571487427, 0.19858911633491516, -0.4397328197956085, 0.22769972681999207, 0.6975252628326416, 0.4047814607620239, 0.23108980059623718, -0.4022371172904968, -0.5382020473480225, -0.006047373171895742, 0.10134618729352951, 0.592570960521698, -0.3788623809814453, -0.18454143404960632, -0.03145917132496834, 0.29915693402290344, -0.22262021899223328, -0.05277128890156746, -0.0755695104598999, -0.27059757709503174, 0.9976062178611755, -0.40268412232398987, -0.4514564275741577, -0.13195213675498962, 0.3128705322742462, -0.07565154135227203, -0.0011836962075904012, 0.08029160648584366, -0.3277586102485657, -0.2213020920753479, 0.03003956936299801, -0.1448357254266739, 0.1693914383649826, -0.3103964030742645, -0.4628463387489319, -1.2555347681045532, 0.053888317197561264, -0.20569270849227905, -0.06422952562570572, -0.4493529498577118, 0.13686321675777435, 0.9932539463043213, 0.14202666282653809, -0.523728609085083, -0.004934821277856827, -0.5242596864700317, -0.26946014165878296, 0.33793312311172485, -0.469224750995636, 0.2885521948337555, -0.154460147023201, -0.17937494814395905, 0.038770683109760284, -0.4590735137462616, 0.2174571305513382, -0.0953616127371788, 0.0025314867962151766, -0.33447784185409546, 0.049178577959537506, 0.7465540170669556, 0.23235386610031128, -0.32040444016456604, -0.15859991312026978, -0.32195553183555603, 0.4944125711917877, 0.01307079941034317, -0.17461316287517548, -0.3236371874809265, -0.24750931560993195, -0.24672627449035645, -0.1854255646467209, 0.6334943175315857, -0.05117465928196907, 0.06929986923933029, 0.310023695230484, -0.1307547390460968, 0.37384486198425293, -0.20396114885807037, 0.04682034254074097, -0.4817322790622711, -0.21545429527759552, 0.31721532344818115, 0.6586965322494507, 0.08401667326688766, 0.6975789666175842, -0.01282542198896408, -0.13311533629894257, 0.1000746414065361, 0.34141412377357483, 0.19561967253684998, -0.5850411653518677, 0.3553345203399658, -0.06738799810409546, -0.29355841875076294, -0.10700616985559464, -0.25958049297332764, -0.25675755739212036, -0.2138475477695465, 0.040208544582128525, -0.8443567752838135, 0.14440999925136566, -0.06120011955499649, 0.23735931515693665, -0.1261403113603592, -0.2043236643075943, 0.16554519534111023, 0.5054817795753479, -0.15449362993240356, 0.19081199169158936, -0.01969156228005886, 0.9388380646705627, 0.31005018949508667, -0.0657557025551796, 0.09727062284946442, -0.06868866831064224, 0.5501564741134644, 0.009634153917431831, -0.1947251558303833, 0.07772219181060791, 0.08501380681991577, 0.7481088042259216, 0.07795502245426178, 0.10113095492124557, -0.3807184100151062, 0.018757231533527374, 0.42640116810798645, 0.2004988044500351, -0.32543542981147766, 0.3724384009838104, -0.16030219197273254, -0.4768230617046356, -0.528010904788971, 0.03191160783171654, 0.22460046410560608, -0.47089138627052307, -0.1050814688205719, 0.46297627687454224, -0.17718665301799774, 0.2917812168598175, -0.4545505940914154, -0.21032077074050903, -0.2197011113166809, -0.0390998013317585, 0.04806594178080559, 0.38905027508735657, -0.8119186758995056, -0.1294914036989212, 0.06499940156936646, 0.16300570964813232, 0.42375484108924866, 0.47364842891693115, -0.5581812262535095, 0.10581257939338684, 0.5068095326423645, 0.04281625151634216, -0.3688797056674957, 0.27670738101005554, -0.31684592366218567, 0.21092931926250458, 0.5040284991264343, 0.11199407279491425, -0.029823483899235725, -0.4499339461326599, -0.6716365814208984, 0.23246116936206818, 0.07359545677900314, 0.5969193577766418, 0.14553561806678772, -0.10549341887235641, -0.8878445625305176, -0.32153573632240295, 0.10034523904323578, -0.38922858238220215, 0.15317222476005554, 0.2668965756893158, 0.48673513531684875, -0.023644067347049713, -0.3569096028804779, -0.2645696997642517, -0.2727121114730835, -0.051044926047325134, 0.5438675880432129, -0.8881824612617493, 1.5194813013076782, 0.05630159378051758, -0.2019997537136078, 1.2088687419891357, 0.3536381423473358, 0.146450936794281, 0.2712653875350952, -0.320650577545166, 0.33064767718315125, -0.0349012091755867, 0.028060251846909523, 0.42384621500968933, -0.16869793832302094, 0.1460038721561432, -0.5132408738136292, 0.033039260655641556, 0.418883353471756, -0.4290753901004791, -0.15177080035209656, 0.2612183094024658, 0.1804647445678711, 0.24788717925548553, -0.008132005110383034, 0.0648716539144516, 0.4447314441204071, -0.5030753016471863, 0.4893082082271576, -0.3059125542640686, 0.554458498954773, 0.19532035291194916, -0.06095448136329651, 0.7307921051979065, 0.07721371948719025, 0.43287619948387146, 0.5042406916618347, -1.2756388187408447, -0.0010020724730566144, -0.29275748133659363, 0.2738291621208191, -0.3635491132736206, -0.18950140476226807, -0.009713632985949516, 0.12616853415966034, 0.005964328534901142, 0.36640405654907227, -0.3024454712867737, 0.07440079003572464, -0.06649267673492432, -0.2620812952518463, 0.5069636702537537, 0.08540227264165878, -0.44795727729797363, 0.3996696174144745, 0.5930479168891907, -0.5364236235618591, -0.06991656869649887, 0.28209877014160156, 0.481436550617218, -0.06948846578598022, -0.31421539187431335, 0.37905749678611755, 0.1898784190416336, 0.019997645169496536, -0.7864011526107788, -0.011475291103124619, 0.04687121510505676, 0.17420130968093872, 0.6051943302154541, 0.24640856683254242, 0.21592573821544647, 0.05387323349714279, -0.6436814069747925, -0.8890324831008911, -0.6458311080932617, 0.5564368367195129, 0.6105073094367981, 0.6255074739456177, -0.3049485385417938, -0.6429673433303833, 0.11590419709682465, 0.16408756375312805, -0.08496008813381195, 0.05996839329600334, -0.03942449390888214, -0.8116635680198669, -0.359795480966568, -0.08534228056669235, 0.46322333812713623, 0.7046439051628113, -0.32909658551216125, -0.07257863134145737, -0.48358407616615295, -0.2287055402994156, -0.18865464627742767, -0.44233569502830505, -0.576409101486206, 0.16893474757671356, 0.3331412672996521, 0.1318892389535904, -0.4250430166721344, 0.030841726809740067, 0.3364960551261902, 0.1674209088087082, 0.5379798412322998, 0.5520660281181335, 0.3861856460571289, -0.4276570975780487, 0.2057407647371292, -0.03990235924720764, -0.2636720538139343, -0.2093588411808014, -0.49545180797576904, -0.6105079054832458, 0.44937756657600403, -6.066425323486328, -0.007099224254488945, -0.04927656427025795, -0.40018200874328613, -0.4826396703720093, 0.04640321806073189, 0.7405219078063965, -0.11976869404315948, 0.29774847626686096, 0.1862453818321228, 0.11321501433849335, 0.3635265529155731, -0.23845221102237701, 0.2834981083869934, 0.186570405960083, -0.16976399719715118, 0.09656304121017456, -0.5814302563667297, 0.15068784356117249, 0.1320430189371109, 0.15239903330802917, -0.04546835646033287, -0.2423003613948822, 0.344815731048584, 0.11603336781263351, 0.04024522751569748, -0.4439114034175873, -0.030192770063877106, -0.048147354274988174, -0.0400831401348114, -0.07661865651607513, -0.34857624769210815, -0.24093009531497955, 0.21301768720149994, 0.4324771761894226, 0.1713239550590515, 0.7696593999862671, 0.07957044243812561, -0.14080828428268433, -0.7442227602005005, -0.02137121744453907, 0.6341275572776794, -0.2890869975090027, -0.3355545699596405, 0.20440083742141724, 0.004142336547374725, -0.41432592272758484, -0.07206258177757263, -0.0177606213837862, 0.1709643304347992, -0.19945551455020905, -0.4070426821708679, 0.1917918473482132, 0.6175505518913269, 0.44178447127342224, 0.05319443717598915, 0.05843488872051239, 0.01353897713124752, -0.20516756176948547, 0.24582011997699738, -0.045386794954538345, -0.2864598035812378, -0.5181560516357422, -1.169477105140686, 0.3006640672683716, 0.20384874939918518, -0.845818042755127, 0.1376924216747284, 0.04607138782739639, 0.19235919415950775, -0.12081095576286316, -0.31419992446899414, 0.02188309095799923, -0.705130398273468, 0.5026335716247559, -0.35656508803367615, 0.38437536358833313, -0.05251189321279526, 0.06268894672393799, -0.06105276197195053, -0.27850204706192017, -0.19513247907161713, 0.13097898662090302, -0.2834527790546417, 0.3398202657699585, -0.18080957233905792, 0.12136802077293396, -0.12374862283468246, 0.19220170378684998, 0.008954903110861778, 0.5270815491676331, -0.17152626812458038, -0.20359109342098236, 0.5315689444541931, 0.06593012809753418, 0.5080882906913757, 0.42192718386650085, 0.19889575242996216, 0.37833157181739807, -0.11087940633296967, 0.46030375361442566, -0.13827939331531525, -0.21969521045684814, -0.6374709010124207, -0.10174873471260071, 0.8992772698402405, -0.5864748954772949, 0.014076189137995243, 0.6539329290390015, -0.5481303930282593, -0.15261855721473694, 0.02357971854507923, -0.2951207160949707, 0.22659918665885925, 0.5996425151824951, -0.0015481800073757768, 0.010955654084682465, 0.08484712988138199, 0.5714055299758911, -0.055481232702732086, -0.010139049030840397, -0.10303094983100891, -0.39886534214019775, 0.273425430059433, -0.32548439502716064, -0.31687498092651367, -0.19872663915157318, 0.3752385675907135, -0.6601526737213135, -0.04067567363381386, 0.26551559567451477, -0.18539537489414215, -0.34353867173194885, 0.54928058385849, 0.40696755051612854, -1.0286340713500977, 0.0156045937910676, 0.17340868711471558, 0.004657577723264694, -0.3977264165878296, 0.3153707683086395, -0.28067514300346375, -0.08955591171979904, 0.002264736918732524, 0.21154679358005524, -0.33171939849853516, 0.03900442644953728, -0.2465074211359024, -0.5639979839324951, 0.38945460319519043, 0.17146705090999603, -0.7382307648658752, -0.017527444288134575, 0.3946571350097656, -0.09982674568891525, 0.3803059756755829, 0.23857811093330383, -0.08074400573968887, 0.2284378707408905, -0.17460954189300537, 0.44023528695106506, 0.33012843132019043, -1.010765552520752, 0.1722978949546814, 0.20921343564987183, -0.7139227390289307, -0.6037559509277344, 0.108440101146698, 0.450494647026062, 0.41239532828330994, -0.11264351010322571, -0.5456196665763855, -0.10181445628404617, -0.17799101769924164, 0.11359906941652298, -0.2401943951845169, -0.39187875390052795, -0.13975000381469727, -0.27630046010017395, 0.14276005327701569, 0.27961426973342896, -0.04125641658902168, -0.33436986804008484, 0.29639753699302673, 0.8813599944114685, 0.38053593039512634, -0.07247389107942581, 0.2423156052827835, -0.3540090322494507, -0.3591592609882355, 0.254647821187973, 0.2112586349248886, 0.11153097450733185, -0.29067161679267883, -0.13590681552886963, -0.1616273671388626, 0.09166809171438217, 0.3221715986728668, 0.10637811571359634, 0.1335487961769104, -0.18985292315483093, -0.042937811464071274, -0.28592273592948914, 0.20004047453403473, 0.2758595943450928, -0.30155259370803833, -0.03255188465118408, -0.02156335860490799, -0.6929672956466675, -0.4765835404396057, -0.36018937826156616, -0.48826631903648376, -0.4804493188858032, 0.020134376361966133, 0.21603083610534668, -0.08670474588871002, 0.08227166533470154, -0.6864157915115356, -0.256382018327713, 0.5250154733657837, 0.27092692255973816, -0.22663559019565582, -0.2915004789829254, 0.1041957288980484, -0.011138208210468292, -0.6387259364128113, 0.2840844392776489, -0.6063315272331238, 0.006705459672957659, 0.16620828211307526, -0.11705063283443451, 0.016834765672683716, 0.4394187331199646, 0.9274954795837402, -0.13496705889701843, -0.16102418303489685, -0.5844833254814148, -0.24295301735401154, -0.1289980560541153, 0.2551504373550415, 0.4326461851596832, 0.47174549102783203, -0.2553449869155884, 0.0973653644323349, 0.24898195266723633, 0.2993720471858978, 0.17550359666347504, -0.44618210196495056, -0.31707674264907837, 0.053695857524871826, 0.24705398082733154, 0.15797846019268036, 0.02030079811811447, 0.21085701882839203, 0.9876317381858826, 0.1953650712966919, -0.02810891903936863, -0.6531709432601929, 0.06917782127857208, 0.45001646876335144, -0.0017459671944379807, -0.18157722055912018, 0.07730236649513245, -0.17401175200939178, -0.032510124146938324, 0.3139466345310211, -0.014568142592906952, -0.3853885531425476, 0.5806336402893066, -0.15196174383163452, 0.20489268004894257, -0.054426442831754684, -0.25052928924560547, 0.1765577346086502, -0.30645737051963806, 0.03455706685781479, -0.32823050022125244, 0.45307624340057373, -0.10974694788455963, 0.18966718018054962, -0.18547093868255615, -0.5691249966621399, -0.0682547390460968, -0.06257031112909317, -0.0738009512424469, -0.18319927155971527, 0.1458693891763687, -0.5027204751968384, -0.11592027544975281, -0.5081297755241394, -0.3172071576118469, 0.25387436151504517, -0.8602594137191772, -0.3349619507789612, -0.030113615095615387, 0.06117994710803032, 0.4731040894985199, 0.6669251918792725, -0.37832003831863403, -0.013300993479788303, 0.005943156313151121, 0.18599466979503632, 0.7250809073448181, -0.5654783844947815, 0.2736201286315918, -0.04509906470775604, 0.19635426998138428, -0.6003572940826416, -0.042968783527612686, -0.3439866900444031, 0.13843178749084473, 0.3543715476989746, 0.44245263934135437, 0.17873087525367737, -0.011963248252868652, -0.01292975340038538, 0.25301557779312134, -0.017126120626926422, 0.07643701136112213, 0.05418514087796211, 0.2632925808429718, 0.14578679203987122, 0.7228063344955444, -0.07036842405796051, -0.34731703996658325, 0.6224556565284729, 0.31037771701812744, -0.13994956016540527, 0.17262087762355804, 0.5922336578369141, 0.5172771215438843, 0.6520423889160156, -0.02139970287680626, 0.36366361379623413, 0.02862982079386711, 0.1563291996717453, 0.3852143883705139, 0.010124454274773598, -0.42776817083358765, 0.08407552540302277, 0.889393150806427, 0.3717021644115448, -0.10949211567640305, 0.0017211452359333634, -0.13831914961338043, 0.3235470652580261, 0.32952845096588135, 0.7039663791656494, -0.35923925042152405, -0.11790713667869568, 0.5933514833450317, 0.12456164509057999, -0.0858863964676857, 0.41120606660842896, 0.2610967457294464, -0.03841102868318558, 0.4671667516231537, 0.01159009337425232, -0.7837705612182617, 0.37581929564476013, -0.2518916428089142, 0.6181557774543762, 0.49524280428886414, 0.09050332009792328, -0.28414446115493774, -0.3595982789993286, 0.049666885286569595, 0.6152435541152954, 0.17324167490005493, -0.2739325165748596, -0.03181746229529381, 0.048098936676979065, -0.6068227291107178, -0.15468835830688477, -0.12350448220968246, -0.5641119480133057, 0.28285589814186096, -0.105736643075943, 0.22605331242084503, 0.23266619443893433, -0.13522882759571075, 0.172488272190094, -0.43373313546180725, -0.5115021467208862, 0.17404526472091675, 0.22815139591693878, -0.13895609974861145, 0.45902910828590393, 0.13889770209789276, 0.10066872835159302, 0.08194190263748169, -0.7060422301292419, -0.13436493277549744, 0.0342290960252285, -0.20168069005012512, 0.12677232921123505, -0.459839791059494, 0.41776788234710693, 0.34060508012771606, 0.34406378865242004, 0.32393696904182434, -0.026501957327127457, -0.09437869489192963, 0.4061936140060425, -0.6257240176200867, 0.6303191781044006, -0.8228470683097839, -0.057197023183107376, -0.7054021954536438, -0.29305341839790344, 0.6163105368614197, 0.15529318153858185, -0.32774680852890015, -0.26591867208480835, -0.2544066607952118, -0.2014136016368866, 0.5439873933792114, -0.48130032420158386, 0.07570888102054596, -0.5756548047065735, -0.4122806787490845, -0.3013836443424225, 0.8692596554756165, -0.2915855050086975, -0.06401658058166504, 0.29944169521331787, 0.0741184800863266, 0.33427301049232483, -0.08991765230894089, 0.18807484209537506, -0.0545244999229908, -0.5187252163887024, -0.16153289377689362, 0.42305728793144226, -0.644129753112793, 0.06869236379861832, -0.3476075828075409, -0.019707147032022476, -0.0170606542378664, -0.3307831287384033, 0.12901078164577484, -0.6487888693809509, -0.05076071247458458, 0.4456498622894287, -0.10614130645990372, 0.10315896570682526, -0.042160749435424805, -0.329401433467865, -0.5473681688308716, -0.1573764532804489, -0.20911864936351776, -0.4446469247341156, -0.26917317509651184, 0.09307632595300674, -0.11077149957418442, -0.0628131702542305, 0.16025656461715698, -0.5587205290794373, -0.2469908744096756, -0.19424448907375336 ]
PURPOSE Patients with type 2 diabetes mellitus (T2DM) have an increased fracture risk despite having higher areal bone mineral density (aBMD). This study aimed to clarify the association between glycemic and insulin resistance status and bone microarchitecture, and whether pentosidine and bone turnover markers play any roles in the association. METHODS A total of 2012 community-dwelling men aged ≥65years completed baseline measurements of spine aBMD, fasting plasma glucose (FPG) and serum insulin, hemoglobin A1c (HbA1c), osteocalcin, type I procollagen N-terminal propeptide, type I collagen C-terminal crosslinking telopeptide, tartrate-resistant acid phosphatase isoenzyme 5b, pentosidine, height and weight and an interview regarding past disease history. Homeostasis model assessment-insulin resistance (HOMA-IR) was also calculated. T2DM was defined as physician-diagnosed middle age or elderly-onset diabetes mellitus, or according to biochemical test results. To evaluate bone microarchitecture, trabecular bone score (TBS) was calculated at the same vertebrae as those used for aBMD measurement. RESULTS After excluding participants who had a disease history and/or were taking medications affecting bone metabolism, 1683 men (age, 72.9±5.2years) were analyzed. Men with T2DM had significantly higher aBMD compared to those without T2DM. There was no significant difference in TBS. However, FPG, HbA1c and HOMA-IR levels were significantly inversely correlated with TBS after adjusting for age, BMI and aBMD. Multivariate linear regression analyses revealed that glycemic indices (FPG and HbA1c) were significantly associated with increased aBMD and decreased TBS, and that HOMA-IR was associated only with TBS. These associations did not change after further adjusting for bone turnover makers and pentosidine levels. CONCLUSIONS Hyperglycemia and elevated insulin-resistance were associated with low TBS independently of bone turnover and pentosidine levels.
[ -0.019642038270831108, 0.014942922629415989, -0.019055381417274475, 0.011869769543409348, 0.0020545341540127993, 0.005545464809983969, 0.010515572503209114, 0.008615099824965, -0.007999131456017494, -0.0009794235229492188, -0.008641212247312069, 0.007690681144595146, -0.006357738748192787, 0.026388339698314667, -0.0031214901246130466, -0.031325019896030426, -0.012711809016764164, -0.011586884036660194, 0.01121449749916792, 0.015808328986167908, -0.0068626850843429565, -0.01931416243314743, 0.010814264416694641, 0.036098413169384, 0.0024985542986541986, 0.0011317143216729164, 0.026886899024248123, -0.02193245105445385, 0.005951132625341415, -0.007983190007507801, -0.02189234271645546, 0.009908454492688179, 0.006209191866219044, -0.0010749660432338715, 0.016844023019075394, -0.015622742474079132, -0.00033594665001146495, 0.022505782544612885, -0.020087098702788353, -0.005340720992535353, -0.00019610347226262093, -0.013791189529001713, 0.003746217815205455, 0.0048451232723891735, -0.010408797301352024, -0.014499509707093239, -0.0013177520595490932, -0.012815465219318867, 0.025111854076385498, 0.00934559479355812, -0.00200511678121984, -0.023866157978773117, -0.01381616573780775, -0.031869567930698395, -0.006377416662871838, 0.002979764249175787, 0.01874147541821003, 0.013686106540262699, 0.0020683594048023224, 0.029149971902370453, 0.0014896686188876629, -0.02829502336680889, -0.0036055156961083412, -0.023973437026143074, -0.010897433385252953, -0.06641031801700592, 0.023345453664660454, -0.009281751699745655, -0.0028453264385461807, 0.0010485141538083553, -0.03086467832326889, 0.007180726155638695, 0.03886130452156067, 0.02147640660405159, -0.01984555646777153, -0.011595706455409527, 0.012366121634840965, 0.017858751118183136, 0.00037636328488588333, 0.018329836428165436, -0.03445712849497795, 0.004697667434811592, -0.003449993208050728, 0.026994477957487106, 0.01247037947177887, -0.005307672545313835, -0.03371572867035866, -0.0003017573617398739, 0.007313706912100315, 0.034990839660167694, 0.014624947682023048, 0.0012549448292702436, -0.0233920905739069, -0.006509913131594658, -0.004431401379406452, -0.017460472881793976, -0.006346818059682846, 0.013203414157032967, 0.012608548626303673, -0.0088848527520895, -0.012087628245353699, 0.00186106376349926, 0.020175738260149956, -0.009253432042896748, -0.015046504326164722, 0.00522258598357439, 0.017148375511169434, -0.015485590323805809, -0.025431916117668152, 0.013510014861822128, 0.0020465338602662086, -0.003718012012541294, -0.012080022133886814, 0.005990662146359682, 0.03523915261030197, 0.02290102280676365, -0.020010141655802727, -0.03242896869778633, 0.0034111402928829193, -0.017477955669164658, -0.006042201071977615, -0.008297021500766277, -0.004486437886953354, 0.008252211846411228, -0.0034088105894625187, -0.01244852039963007, 0.004929674789309502, -0.0138163510710001, 0.007625258062034845, -0.005883061792701483, -0.0066906241700053215, -0.003146388567984104, -0.01517424639314413, 0.039595071226358414, -0.006999628618359566, -0.002856375416740775, -0.029672345146536827, -0.005972070619463921, -0.009459401480853558, -0.01163632981479168, 0.010662882588803768, 0.011602472513914108, 0.008978523313999176, 0.0033465551678091288, 0.008632565848529339, 0.0022836981806904078, -0.008413159288465977, -0.006358245387673378, 0.009219488129019737, -0.006295559462159872, 0.022523939609527588, 0.020171841606497765, -0.04117872193455696, -0.011462299153208733, 0.003994134720414877, -0.002983314450830221, -0.005066823214292526, 0.0059857675805687904, -0.0028512345161288977, 0.013991085812449455, -0.017226818948984146, 0.0019369112560525537, 0.021788369864225388, 0.010977215133607388, -0.013529024086892605, 0.0200638584792614, -0.008349540643393993, -0.02290329895913601, 0.015430400148034096, 0.007118863053619862, -0.009855764918029308, -0.009478289633989334, 0.017306223511695862, 0.009894675575196743, -0.006479551084339619, 0.008468518033623695, -0.011156671680510044, 0.008692732080817223, -0.0024077040143311024, 0.06574950367212296, -0.002625737339258194, -0.001969452016055584, -0.010379679501056671, -0.007743524387478828, -0.0037475558929145336, -0.010733531787991524, 0.00825425237417221, -0.012268409132957458, -0.0017294539138674736, 0.010174330323934555, 0.0008502963464707136, 0.006813868880271912, -0.00464507844299078, 0.003933466970920563, -0.003658971283584833, 0.002562802517786622, -0.007049032486975193, -0.005424290429800749, 0.01567176915705204, 0.030925914645195007, -0.0059811268001794815, -0.007402178831398487, 0.013414252549409866, -0.01344259176403284, 0.013446930795907974, 0.022914892062544823, 0.008551066741347313, -0.011056529358029366, -0.002091257832944393, -0.014396825805306435, -0.0011940972181037068, -0.013319406658411026, 0.005128568969666958, -0.004111393820494413, -0.01183808222413063, -0.008378935977816582, -0.025721166282892227, 0.004426955245435238, -0.018075542524456978, -0.01062323059886694, 0.0028976364992558956, -0.002720567397773266, -0.05563254654407501, 0.0007182636763900518, 0.033954840153455734, -0.027819857001304626, -0.011224426329135895, 0.012656092643737793, -0.007605608552694321, 0.006881890818476677, 0.0037854518741369247, -0.0011357460170984268, -0.01448788121342659, 0.003031156025826931, -0.003565989900380373, -0.03487834334373474, 0.017101220786571503, -0.024995893239974976, 0.014078540727496147, -0.011497685685753822, -0.014590545557439327, -0.0144121078774333, 0.025665689259767532, -0.005764448549598455, 0.04753107577562332, -0.0036136023700237274, -0.02254016324877739, 0.02001120150089264, -0.012671309523284435, -0.0011070502223446965, 0.005997872445732355, -0.012672383338212967, 0.014351410791277885, 0.0054067084565758705, -0.012978564947843552, -0.01990494877099991, 0.0029380563646554947, -0.01052074320614338, 0.026094235479831696, -0.010043658316135406, 0.0005641728639602661, 0.008575855754315853, -0.0024095866829156876, -0.0035924625117331743, -0.006255638785660267, 0.0010968686547130346, -0.006761952769011259, 0.009681515395641327, 0.010405631735920906, -0.008815640583634377, 0.005416823551058769, -0.003036747919395566, -0.0006792622152715921, -0.0814862847328186, -0.018454108387231827, -0.01490724179893732, -0.002898543607443571, 0.0043589649721980095, -0.018260011449456215, 0.01653437502682209, 0.0016448379028588533, -0.009096913039684296, -0.01526243332773447, 0.007828469388186932, 0.002475364599376917, -0.004566171206533909, 0.001685410737991333, 0.006832505576312542, -0.014589434489607811, 0.009876906871795654, -0.0031110821291804314, 0.00973707064986229, -0.022928662598133087, 0.024228179827332497, 0.011898213997483253, 0.023714691400527954, -0.010164283215999603, -0.004096946679055691, -0.00815221481025219, 0.03733184561133385, -0.006833991035819054, -0.03883540630340576, 0.018011171370744705, 0.025131594389677048, -0.014331449754536152, -0.008365089073777199, 0.010642205365002155, -0.006261787377297878, -0.003035461064428091, -0.004567022901028395, -0.0019080613274127245, 0.005082967225462198, 0.04172176867723465, -0.007939185947179794, 0.0019132684683427215, -0.008959293365478516, 0.005380657967180014, 0.006449678912758827, 0.006097571458667517, 0.014953585341572762, -0.009033355861902237, 0.018193691968917847, -0.017896484583616257, -0.006750844419002533, -0.003579669864848256, 0.032847724854946136, 0.015558822080492973, -0.027006469666957855, -0.020454859361052513, -0.024261068552732468, 0.009733413346111774, -0.009973710402846336, -0.016268551349639893, -0.008541734889149666, -0.02621135674417019, 0.0226634182035923, 0.01486714743077755, -0.010014552623033524, -0.010228714905679226, 0.0035578086972236633, 0.0064987908117473125, -0.02570461481809616, 0.007651308085769415, -0.016698691993951797, -0.016772855073213577, -0.012233787216246128, -0.010108972899615765, -0.004896658472716808, -0.012218780815601349, -0.01617167517542839, -0.010040303692221642, -0.006013460922986269, 0.0045135170221328735, 0.013007497414946556, -0.005885430611670017, -0.01740184612572193, -0.01484308484941721, -0.0028256243094801903, 0.005591625347733498, 0.012451338581740856, 0.039692748337984085, 0.01907976344227791, -0.013134557753801346, 0.009894435293972492, 0.03269436955451965, -0.03391380235552788, 0.014758134260773659, -0.0131966108456254, 0.003187312511727214, -0.007004449609667063, -0.01372175570577383, 0.016412809491157532, 0.007068818900734186, 0.0027270943392068148, 0.014842769131064415, -0.009728776291012764, -0.01764960214495659, -0.009976807050406933, 0.017958302050828934, 0.0012207294348627329, 0.02032361552119255, -0.01636585220694542, -0.006237433757632971, -0.004714627750217915, 0.004663088824599981, -0.0014506308361887932, 0.02575453743338585, 0.009654154069721699, 0.0034274235367774963, -0.002601927611976862, -0.008191079832613468, 0.07242609560489655, 0.0036406838335096836, 0.01652723178267479, -0.008974320255219936, -0.001046696794219315, -0.017447520047426224, -0.010765263810753822, 0.009941939264535904, 0.008562790229916573, -0.011934156529605389, 0.013066689483821392, -0.0011591104557737708, 0.03937961906194687, 0.011120911687612534, -0.031079843640327454, 0.01672416552901268, 0.004709318280220032, 0.01220093946903944, 0.01229272224009037, -0.008530037477612495, 0.016780337318778038, -0.020496321842074394, -0.015173640102148056, -0.005971189588308334, 0.0010238608811050653, -0.020383324474096298, -0.016912341117858887, -0.013046108186244965, -0.0241292305290699, 0.003526347689330578, 0.000492950901389122, 0.008263958618044853, -0.009311187081038952, -0.0074149854481220245, 0.0011734627187252045, 0.005535473115742207, 0.001620074617676437, 0.03601063787937164, 0.032145727425813675, -0.02094171568751335, -0.03819940984249115, -0.013605309650301933, 0.025033697485923767, 0.009667482227087021, -0.02078278735280037, 0.004552765283733606, 0.0023241257295012474, -0.0069231935776770115, 0.00322555610910058, 0.0061830319464206696, 0.003147604176774621, 0.0027188430540263653, 0.005561064463108778, 0.010159059427678585, 0.0009846683824434876, -0.0060431258752942085, -0.0027859224937856197, -0.005556770600378513, 0.024834562093019485, -0.00175930792465806, -0.017605571076273918, 0.02870774082839489, 0.00430519413203001, -0.006927940994501114, -0.017078731209039688, -0.01831972785294056, 0.026080921292304993, -0.016888190060853958, 0.0066301655024290085, -0.020014464855194092, 0.013162553310394287, -0.00031574442982673645, 0.026477834209799767, 0.0109599269926548, -0.010798109695315361, -0.012770052999258041, -0.01704040914773941, 0.0031551504507660866, 0.005906518083065748, 0.005266855470836163, -0.005353357642889023, -0.008984331041574478, 0.025978833436965942, -0.01193709671497345, -0.0009772093035280704, 0.00874279998242855, -0.006800004281103611, -0.07498820871114731, 0.007969925180077553, -0.02157452329993248, -0.012434571050107479, -0.021378975361585617, -0.006933046039193869, -0.021195340901613235, -0.0197279192507267, -0.025933844968676567, -0.00251326453872025, -0.0010652635246515274, 0.0042308662086725235, -0.00757630355656147, -0.003068863181397319, 0.012495063245296478, 0.036528244614601135, -0.018274283036589622, -0.013189442455768585, -0.012396633625030518, -0.024112703278660774, 0.0067758322693407536, 0.04279065132141113, -0.006966276094317436, -0.004263700917363167, 0.0009325087303295732, -0.08128596842288971, -0.006334217265248299, 0.004020868334919214, 0.002987215295433998, 0.007080398499965668, -0.034252382814884186, 0.02893393114209175, 0.00008328352123498917, -0.003818108234554529, -0.01740202307701111, 0.008067311719059944, 0.005483188200742006, -0.01866668090224266, 0.010940207168459892, -0.011883104220032692, -0.0018692464800551534, 0.0013501227367669344, 0.03995472565293312, -0.03703899681568146, -0.011205801740288734, 0.009897523559629917, 0.005117776338011026, -0.00418023020029068, 0.02030777372419834, -0.016392096877098083, 0.0154410470277071, 0.017329324036836624, 0.01350594311952591, 0.019548213109374046, -0.005051550921052694, 0.00997987575829029, 0.0119104515761137, -0.00713562173768878, 0.013602823950350285, -0.013362622819840908, -0.019629377871751785, 0.0025813542306423187, -0.008849355392158031, 0.02039872668683529, -0.02059166133403778, -0.0022460089530795813, 0.01413242518901825, -0.0008642380125820637, 0.006736402399837971, -0.0283301193267107, 0.012474514544010162, 0.004911373369395733, -0.018101057037711143, 0.006188725586980581, 0.01594739407300949, 0.00432306295260787, -0.007340589538216591, 0.006077076308429241, -0.008037632331252098, -0.0016182349063456059, -0.01855725795030594, -0.013132445514202118, 0.021752318367362022, 0.018455952405929565, 0.010303746908903122, 0.00027395703364163637, 0.0063372282311320305, -0.008404532447457314, 0.07091859728097916, -0.00656794011592865, -0.010045633651316166, 0.0058967350050807, -0.017856156453490257, 0.005838296376168728, -0.013531132601201534, -0.0004093504976481199, -0.010610764846205711, -0.00018097873544320464, -0.030630212277173996, -0.024839308112859726, -0.013685093261301517, 0.012862758710980415, -0.008604229427874088, -0.022389084100723267, 0.008170006796717644, -0.0065332744270563126, 0.004439887125045061, -0.012825710698962212, 0.011380260810256004, 0.04110858589410782, -0.005880627315491438, 0.00005918974056839943, 0.006852844730019569, -0.009177092462778091, -0.003153309691697359, -0.008933990262448788, -0.014438023790717125, 0.019761299714446068, -0.0012376531958580017, 0.016210485249757767, 0.010873371735215187, 0.01917453296482563, 0.020045127719640732, 0.019442224875092506, 0.003075066953897476, 0.011359921656548977, -0.011730041354894638, 0.0021218820475041866, 0.013493657112121582, 0.008033866062760353, -0.0019502474460750818, -0.03202038258314133, 0.026862040162086487, -0.012329640798270702, -0.0030615844298154116, 0.006425537168979645, -0.009638454765081406, -0.0021512885577976704, -0.008330326527357101, -0.005626128055155277, 0.015957918018102646, 0.014047352597117424, -0.0005354140885174274, -0.011866491287946701, -0.03228069841861725, 0.009522993117570877, 0.005348666571080685, 0.005429517477750778, -0.01296633668243885, -0.016791487112641335, 0.00034069735556840897, -0.02243131399154663, 0.030661078169941902, -0.026474518701434135, 0.005361576564610004, -0.015373611822724342, 0.01169056911021471, 0.014269068837165833, -0.008064641617238522, 0.014889921993017197, 0.007870647124946117, 0.0031573944725096226, 0.013600248843431473, -0.00996378343552351, -0.026818301528692245, -0.009685268625617027, 0.009796853177249432, -0.0013841339386999607, -0.0036403420381247997, -0.01359536498785019, -0.0022458438761532307, -0.005283046513795853, 0.003425524104386568, -0.025473644956946373, -0.006922418251633644, 0.005106719210743904, -0.00800725445151329, 0.008520332165062428, 0.005934945773333311, -0.019711658358573914, -0.0021714125759899616, 0.04142916947603226, 0.007378880865871906, 0.034672822803258896, -0.0029469626024365425, 0.005159375257790089, -0.01050515752285719, -0.009467065334320068, 0.011056315153837204, -0.009869525209069252, -0.015347856096923351, 0.047980546951293945, -0.014865569770336151, 0.008723247796297073, 0.03899826854467392, -0.025074657052755356, 0.01678371988236904, 0.0030715088360011578, -0.028071755543351173, -0.03564632683992386, 0.024574965238571167, 0.03305373340845108, 0.016956426203250885, 0.036186158657073975, -0.0039533767849206924, 0.01296432875096798, 0.004405887797474861, -0.015816792845726013, 0.0015599805628880858, -0.005948368459939957, 0.010877665132284164, -0.0077182273380458355, -0.003632007632404566, 0.004422878380864859, -0.01350246649235487, 0.009109431877732277, 0.007592313922941685, -0.0030120154842734337, 0.02621379680931568, -0.009340234100818634, 0.0035582389682531357, -0.01228486280888319, 0.005965657997876406, 0.0036488287150859833, -0.011793801560997963, 0.01263441052287817, -0.01527705229818821, -0.006806415971368551, -0.016730695962905884, 0.004657190293073654, -0.005047622136771679, 0.02514786273241043, 0.009349116124212742, 0.015861809253692627, 0.004586540628224611, 0.014551948755979538, 0.020316965878009796, -0.004859032109379768, 0.00035779643803834915, 0.005503516178578138, 0.011106486432254314, -0.0044548409059643745, -0.01121654361486435, 0.006376953795552254, 0.011117435060441494, 0.01993127353489399, -0.008908923715353012, -0.009889361448585987, 0.007833211682736874, 0.008938794955611229, -0.0010733261005952954, 0.01336208637803793, 0.011545022949576378, -0.013028951361775398, -0.0028965589590370655, -0.008955555967986584, -0.025056425482034683, 0.007596800569444895, 0.0016594124026596546, 0.017746230587363243, -0.0028365636244416237, 0.01903243362903595, -0.015390787273645401, -0.0016368913929909468, -0.008550990372896194, 0.0010739397257566452, 0.02309400402009487, 0.04324007406830788, 0.009037448093295097, 0.013816982507705688, -0.006315433420240879, -0.008329394273459911, -0.006487475708127022, 0.0032819369807839394, -0.01940390095114708, -0.0011361816432327032, 0.007415072526782751, -0.0201374813914299, -0.004214715678244829, -0.007288871333003044, -0.02345404028892517, -0.013701020739972591, 0.00012045912444591522, 0.013905936852097511, -0.0006517460569739342, -0.007755310274660587, 0.0037199542857706547, 0.017880253493785858, 0.012913152575492859, -0.021913474425673485 ]
[ 0.17531126737594604, 0.23855112493038177, 0.4930932819843292, -0.20907270908355713, -0.007865523919463158, 0.09648379683494568, 0.9428315162658691, -0.7103111743927002, -0.28683188557624817, -0.21855947375297546, 0.19451606273651123, 0.4588777422904968, -0.10653699189424515, -0.2964215576648712, 0.30784234404563904, 0.8252215385437012, 0.5844077467918396, 0.0718025416135788, -0.13981445133686066, -0.4972299635410309, -0.14559267461299896, -0.5327619910240173, 0.7959415912628174, -0.4588182866573334, -0.14298436045646667, 0.29756537079811096, 0.4649916887283325, -0.11103583127260208, -0.3007829487323761, -0.29953256249427795, 0.0669865608215332, 0.31057339906692505, -0.09227368235588074, -0.18702204525470734, -0.13073068857192993, 0.7356491684913635, -0.15297579765319824, -0.13707414269447327, -0.1233467161655426, -0.29329192638397217, -0.12680912017822266, -0.2734902799129486, -0.006142102647572756, 0.2864881753921509, -0.3089396059513092, -0.2763752043247223, -1.3165282011032104, 0.11710470914840698, -0.006876152474433184, 0.30014094710350037, 0.1978440135717392, 0.6447441577911377, 0.2288534790277481, 0.11965812742710114, 0.17720463871955872, 0.2679624855518341, -0.29965439438819885, -0.4249438941478729, -0.06487646698951721, -0.5381361246109009, 0.15831692516803741, 0.01586742326617241, -0.18023768067359924, 0.2530393600463867, -0.5281214714050293, 0.4765528440475464, -0.22693350911140442, 0.178734689950943, -0.14976634085178375, -0.02124512381851673, 0.3070119619369507, -0.23417040705680847, -0.34363430738449097, 0.4478491544723511, 0.22951914370059967, -0.14874117076396942, -0.17322194576263428, -0.0553215853869915, 0.330511212348938, -0.021514005959033966, 0.10267113894224167, 0.46350687742233276, 0.331258088350296, -0.09441520273685455, -0.07893425226211548, 0.45688846707344055, 0.2145209163427353, 0.634199857711792, -0.04694022238254547, 0.006464693229645491, -0.10924413800239563, -0.058928411453962326, 0.5081830024719238, 0.12191268801689148, 0.1141618862748146, 0.23085299134254456, -0.054644759744405746, -0.29181721806526184, 0.47794848680496216, 0.19416570663452148, 0.2810816168785095, -0.0366331972181797, -0.24577835202217102, 0.2254006713628769, -0.2367231249809265, 0.02792000211775303, -0.30153486132621765, -0.8513603210449219, -0.6742385029792786, 0.23567187786102295, -1.0202577114105225, -0.4402198791503906, -0.35931652784347534, -0.36706650257110596, -0.24726693332195282, 0.2530558407306671, 0.26595890522003174, -0.24416428804397583, -0.5454959869384766, 0.4323382079601288, 0.35006019473075867, 0.43735381960868835, 0.05434808507561684, 0.26450514793395996, 0.2199508100748062, 0.03177284076809883, 0.30837303400039673, 0.13283434510231018, -0.03469887375831604, 0.7272613048553467, 0.14703717827796936, 0.2948373258113861, 0.16393427550792694, -0.33066460490226746, 0.10664118826389313, -0.46720531582832336, 0.10238318145275116, 0.06588966399431229, -0.5203328132629395, 0.45075294375419617, -0.26430854201316833, -0.5708288550376892, -0.5011506676673889, -0.24298296868801117, 0.21932071447372437, -0.355604887008667, 0.0648033544421196, 0.1929600089788437, -0.12288030236959457, 0.18320922553539276, -0.18353959918022156, 0.1770799309015274, -0.15680751204490662, 0.03331533819437027, 0.2001456469297409, 1.1183315515518188, -0.6663511395454407, -0.4121430516242981, -0.10175411403179169, -0.24746806919574738, 0.2795233428478241, 0.4658859670162201, -0.36344510316848755, -0.31475698947906494, 0.48578938841819763, 0.2002306431531906, 0.2437775731086731, 0.19472883641719818, 0.3133009672164917, -0.1907225251197815, -0.5081046223640442, -0.7376605272293091, 0.030639560893177986, -0.6945029497146606, -0.45652157068252563, -0.020557891577482224, 0.13705573976039886, 0.11114516854286194, 0.05180208012461662, 0.23156264424324036, -0.7150120735168457, -0.10095618665218353, -0.2603413462638855, -0.6382274627685547, 0.48168110847473145, -0.10996326059103012, 0.6948274970054626, 0.13585183024406433, 0.45353057980537415, 0.10615509003400803, 0.029812946915626526, -0.1655624806880951, 0.6955944299697876, -0.5895751714706421, 1.6900776624679565, -0.20683243870735168, -0.49032923579216003, 1.1193714141845703, -0.2018621563911438, -0.0004736809351015836, 0.1840391904115677, -0.014942360110580921, 0.39193016290664673, 0.11058524996042252, -0.6600326299667358, -0.042114872485399246, 0.39209485054016113, -0.4504600167274475, 0.02039743773639202, 0.041944149881601334, 0.20615920424461365, -0.8639710545539856, -0.12169397622346878, -0.3142409026622772, 0.2313743680715561, -0.03231579437851906, 0.3582976758480072, 0.04592740535736084, -0.36040207743644714, -0.05024479329586029, 0.3758160173892975, -0.1908901184797287, 0.05001673102378845, 0.5355896353721619, -0.6697324514389038, 0.6970170140266418, 0.5450131297111511, 0.04837072640657425, 0.347328782081604, -0.437523752450943, 0.1354493796825409, 0.4167459011077881, 0.5452467799186707, -0.28087136149406433, -0.06596454232931137, 0.29316121339797974, 0.042392779141664505, -0.4797724485397339, -0.02152876928448677, -0.07051092386245728, -0.05443914607167244, 0.6918169856071472, -0.26215487718582153, -0.2840607762336731, 0.22243721783161163, -0.5282689929008484, -0.1212303414940834, 0.6876681447029114, -1.1748998165130615, 0.02165626734495163, -0.2595650851726532, 0.22652459144592285, 0.24144169688224792, -0.06885699927806854, 0.34691572189331055, 0.2672503888607025, -0.14470410346984863, -0.4361613690853119, -0.34561002254486084, -0.30927908420562744, -0.40536579489707947, 0.11053060740232468, 0.08422144502401352, 0.03251076489686966, -0.1762399822473526, -0.24218890070915222, -0.6115819811820984, -0.2638043761253357, 0.5168381333351135, 0.7992593050003052, 0.7380307912826538, -0.14543218910694122, -0.8730238080024719, -0.050386521965265274, -0.045062337070703506, -0.15437108278274536, 0.5286047458648682, 0.4284084737300873, -0.4056893587112427, -0.23013906180858612, -0.06718876212835312, 0.4236978590488434, 1.1666611433029175, -0.18011751770973206, 0.08205872029066086, -0.07670249044895172, -0.4092361330986023, -0.4725094139575958, -0.4213148057460785, 0.059948500245809555, -0.17042046785354614, 0.249813973903656, -0.2892521619796753, -0.3757457137107849, 0.4429986774921417, 0.28107234835624695, -0.023861736059188843, 0.36953285336494446, 1.071365475654602, -0.021090121939778328, -0.39612680673599243, -0.44644057750701904, -0.1162286326289177, -0.20221863687038422, -0.05365004763007164, -0.2574664056301117, -0.44742146134376526, 0.05811097100377083, -6.0338311195373535, -0.4018227458000183, -0.6092073917388916, -0.08158835768699646, -0.022274458780884743, 0.22508609294891357, 0.6916235685348511, 0.18582989275455475, 0.22010786831378937, 0.12825524806976318, 0.3941490650177002, 0.5543343424797058, 0.3145918548107147, -0.06963732838630676, -0.1852167397737503, 0.54750657081604, 0.08120537549257278, -0.20375549793243408, 0.36814674735069275, -0.08244562149047852, 0.6102707982063293, -0.1556224673986435, 0.0342121347784996, 0.32739579677581787, 0.34713369607925415, 0.4891325831413269, -1.2467067241668701, 0.3195631206035614, -0.03594914823770523, -0.2591297924518585, 0.45867159962654114, -0.17591209709644318, -0.1297212392091751, -0.3323790431022644, 0.5436064004898071, 0.18646200001239777, 0.32819393277168274, 0.258663147687912, 0.05684280022978783, -0.4248885214328766, 0.3717277944087982, 0.02093316614627838, -0.17316840589046478, 0.1336277723312378, 0.20787888765335083, -0.17832425236701965, -0.03295265510678291, 0.4317919909954071, -0.1658858060836792, 0.24549344182014465, 0.13588713109493256, -0.12111540138721466, 0.10909400135278702, 0.7348938584327698, 0.27916842699050903, -0.08408071100711823, 0.06451377272605896, 0.47807958722114563, -0.3736516833305359, 0.40721142292022705, -0.028108742088079453, -0.03315090388059616, -0.630649745464325, -0.9552107453346252, -0.3666115403175354, 0.2609289884567261, -0.41045668721199036, -0.3017244338989258, 0.3134664297103882, -0.03513948991894722, -0.3523581624031067, 0.22633694112300873, 0.30410224199295044, -0.5709226727485657, 0.6049020290374756, -0.30748990178108215, 0.2612743079662323, 0.2644045948982239, -0.2669494152069092, -0.11962650716304779, -0.3066345453262329, -0.14875353872776031, 0.26919370889663696, 0.15274536609649658, 0.16223649680614471, -0.3012271523475647, -0.4313197135925293, -0.3771953284740448, 0.09286905825138092, 0.7038590312004089, 0.20826590061187744, -0.4031654894351959, 0.2802745997905731, 0.480762243270874, 0.020550303161144257, 0.20151498913764954, 0.283104807138443, 0.18895772099494934, 0.5451739430427551, -0.43996554613113403, 0.5970739722251892, 0.06368285417556763, -0.07339317351579666, -0.9137057065963745, -0.14616699516773224, -0.22078056633472443, -0.6420915722846985, 0.06785445660352707, 0.49329784512519836, -0.6969512701034546, 0.07771547138690948, -0.28056415915489197, -0.6081362962722778, 0.07199033349752426, 0.23505282402038574, -0.11739245802164078, -0.2711330056190491, 0.2337677925825119, 0.3928394913673401, -0.33388105034828186, -0.10369490832090378, 0.3412741422653198, -0.09093689173460007, -0.266441285610199, -0.27810633182525635, -0.08675385266542435, -0.18643121421337128, 0.5582284331321716, -0.6254161596298218, 0.24417516589164734, 0.14710097014904022, 0.8073073029518127, -0.2621375024318695, -0.014844492077827454, 0.2550249695777893, -0.42435938119888306, -0.6518375277519226, 0.7047447562217712, 0.3636721074581146, -0.1686820387840271, 0.593041718006134, -0.14690347015857697, 0.0746292993426323, 0.21015065908432007, -0.3482828438282013, -0.35653945803642273, -0.019177259877324104, -0.2776135802268982, -0.14782194793224335, 0.002493270207196474, 0.32069867849349976, -0.13839960098266602, 0.18461814522743225, 0.12854909896850586, -0.3906291723251343, 0.21418143808841705, 0.3892793357372284, -0.03231346607208252, 0.07969295978546143, -0.46609193086624146, 0.3753783106803894, 0.029151370748877525, -0.9688419103622437, -0.3125462234020233, -0.11739063262939453, 0.07451862841844559, -0.3485592007637024, -0.3805055022239685, 0.30343326926231384, 0.44732651114463806, 0.12480306625366211, -0.7931022644042969, -0.1687111109495163, 0.02766292728483677, 0.1442343145608902, 0.002327010966837406, -0.21859943866729736, -0.4354870021343231, -0.03272771090269089, 0.1652746945619583, 0.03236527740955353, -0.7890902757644653, -0.04108002036809921, 0.04317651689052582, 0.8856821656227112, -0.18869031965732574, 0.15829496085643768, -0.4026111662387848, 0.03445228561758995, -0.43584170937538147, 0.30767932534217834, -0.03417988494038582, 0.4866604208946228, -0.29176875948905945, 0.34797704219818115, -0.16074536740779877, 0.5320141911506653, 0.7575061321258545, -0.11299114674329758, -0.1972983181476593, 0.16209019720554352, 0.05032184720039368, -0.09444523602724075, -0.06770141422748566, 0.8594692349433899, -0.2257039099931717, -0.37862005829811096, -0.1034926325082779, -0.05753332003951073, -0.31601211428642273, -0.11130862683057785, -0.4877091646194458, 0.3647781014442444, 0.1674315631389618, -0.26424941420555115, 0.12662510573863983, 0.1671782284975052, -0.4318506419658661, -0.4859984815120697, 0.26098713278770447, 0.054442353546619415, -0.15774358808994293, -0.6627506017684937, -0.0006387671455740929, -0.3293628692626953, -0.21955116093158722, 0.43367260694503784, -0.8596327304840088, 0.06822369992733002, 0.10413919389247894, -0.41848811507225037, -0.24189284443855286, -0.10704369097948074, -0.07672279328107834, -0.3912576735019684, 0.13637204468250275, -0.5266364216804504, 0.4262726902961731, 0.12000984698534012, 0.009623927064239979, -0.18883880972862244, 0.7518007159233093, -0.14210529625415802, -0.1887216567993164, 0.11117204278707504, 0.5444120764732361, 0.08084681630134583, -0.9681519865989685, -0.013568086549639702, 0.43124157190322876, 0.09686526656150818, -0.10546159744262695, 0.18880940973758698, 0.21852318942546844, 0.7094271779060364, 0.3108058273792267, -0.3062373995780945, -0.5869426727294922, -0.014463497325778008, 0.364246666431427, -0.30283844470977783, 0.4626544415950775, 0.09476397931575775, -0.14050167798995972, -0.3516855835914612, -0.2029189020395279, 0.13813051581382751, -0.7458300590515137, 0.5380041599273682, 0.020953301340341568, 0.0027689123526215553, -0.13490723073482513, 0.21815772354602814, 0.7336117029190063, -0.194305419921875, -0.14797033369541168, -0.4059459865093231, -0.06415311247110367, 0.2455383539199829, 0.5091778039932251, -0.22288714349269867, -0.5540359616279602, 0.2247486710548401, -0.11326564848423004, 0.5759874582290649, -0.39133813977241516, 0.5942869186401367, -0.3791671693325043, -0.33813801407814026, -0.13942378759384155, -0.033299289643764496, 0.08572978526353836, -0.3472099304199219, -0.46297577023506165, -0.29464641213417053, 0.2663758099079132, -0.08733786642551422, -0.05113096907734871, -0.2482324242591858, -0.4588078260421753, -0.09879709035158157, 0.7564947009086609, 0.4615454077720642, -0.5018698573112488, -0.12182539701461792, 0.39960598945617676, 0.060914285480976105, -0.7838143110275269, -0.19221805036067963, -0.29882189631462097, 0.027936624363064766, -0.1481981724500656, 0.4958905577659607, 0.5356517434120178, 0.0035266426857560873, 0.010962577536702156, -0.3755277097225189, 0.09288127720355988, 0.2145088165998459, 0.37151914834976196, 0.040887124836444855, 0.585440993309021, 0.6322489380836487, -0.34093430638313293, 0.17116893827915192, 0.3042115569114685, 0.2593873143196106, 0.08527873456478119, 0.18057073652744293, 0.6302961111068726, 0.6013845205307007, 0.06326442956924438, 0.031100530177354813, 0.6407811045646667, 0.4042361378669739, 0.34364718198776245, 0.01609966903924942, 0.14361584186553955, -0.16481035947799683, 0.0889214426279068, 0.6413922905921936, 0.14788022637367249, -0.24701155722141266, -0.03814546391367912, 0.08517217636108398, 0.3447888493537903, -0.09270486235618591, 0.2302560657262802, 0.21988269686698914, -0.2434735745191574, 0.4404186010360718, 0.1995282918214798, -0.14533814787864685, 0.46265894174575806, -0.7063015103340149, -0.012079833075404167, 0.009664068929851055, -0.23518168926239014, -0.5511111617088318, 0.10203376412391663, 0.130988210439682, -0.09006991237401962, -0.050793878734111786, 0.3859228491783142, -0.05651805177330971, -0.5932002067565918, 0.17407096922397614, 0.08986201882362366, 0.19865627586841583, -0.18203240633010864, -0.2704950273036957, 0.5882591009140015, -0.5145944952964783, 0.22252513468265533, -0.24277377128601074, -0.38494452834129333, -0.016291797161102295, -0.05121064558625221, 0.019089799374341965, -0.12961190938949585, -0.07203494012355804, -0.16345901787281036, -0.2607371211051941, -0.5876948833465576, -0.17797094583511353, -0.3850489854812622, 0.2621431052684784, 0.16451124846935272, -0.1632477194070816, -0.053368426859378815, 0.03883623704314232, -0.5890716314315796, 0.18129168450832367, -0.5195397138595581, 0.2908594608306885, -0.15554790198802948, -0.3095806837081909, 0.17456766963005066, 0.4379863142967224, 0.3040345311164856, 0.09169828146696091, 0.1020134910941124, -0.046785514801740646, 0.32232972979545593, -0.5951409935951233, 0.44757139682769775, -0.2757168114185333, 0.19835832715034485, -0.6101059317588806, -0.03370055928826332, 0.7008941173553467, 0.5260787010192871, -0.21557894349098206, 0.10059966892004013, 0.24142451584339142, 0.39579343795776367, 0.17599816620349884, -0.650810956954956, -0.20171566307544708, 0.03227369487285614, -0.21855472028255463, -0.6909231543540955, 0.684546709060669, 0.07307275384664536, -0.37837719917297363, -0.36538422107696533, 0.46508926153182983, -0.14395597577095032, 0.16078068315982819, 0.29058510065078735, -0.31109195947647095, 0.047708213329315186, -0.131927490234375, 0.3818114995956421, -0.5254238247871399, -0.17549166083335876, -0.32788318395614624, 0.09039226919412613, -0.15245947241783142, -0.39327552914619446, 0.03539445623755455, -0.4086587727069855, -0.07863067835569382, 0.20036067068576813, 0.06453906744718552, 0.1642497032880783, -0.13686850666999817, -1.0379948616027832, -0.2516108453273773, 0.13959914445877075, 0.3014766573905945, -0.4300841689109802, -0.28832346200942993, -0.572952151298523, 0.5146021842956543, 0.30177509784698486, 0.21743182837963104, -0.34576013684272766, 0.013978952541947365, -0.18699434399604797 ]
Pulmonary hypertension (PH) is a deadly vascular disease with enigmatic molecular origins. We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and pervasive processes that promote PH. In multiple pulmonary vascular cell types, such ECM stiffening induced the microRNA-130/301 family via activation of the co-transcription factors YAP and TAZ. MicroRNA-130/301 controlled a PPAR?-APOE-LRP8 axis, promoting collagen deposition and LOX-dependent remodeling and further upregulating YAP/TAZ via a mechanoactive feedback loop. In turn, ECM remodeling controlled pulmonary vascular cell crosstalk via such mechanotransduction, modulation of secreted vasoactive effectors, and regulation of associated microRNA pathways. In vivo, pharmacologic inhibition of microRNA-130/301, APOE, or LOX activity ameliorated ECM remodeling and PH. Thus, ECM remodeling, as controlled by the YAP/TAZ-miR-130/301 feedback circuit, is an early PH trigger and offers combinatorial therapeutic targets for this devastating disease.
[ -0.0018110014498233795, 0.013599596917629242, -0.017125315964221954, 0.02186758443713188, -0.026125624775886536, -0.022320441901683807, 0.009737290441989899, 0.00606321869418025, -0.01302555575966835, -0.03619617223739624, -0.007801171392202377, 0.011928660795092583, -0.015114855021238327, 0.013871555216610432, 0.01715720444917679, 0.00977859366685152, -0.00021097611170262098, 0.0138735705986619, 0.014175903052091599, -0.0062996018677949905, 0.01258309930562973, 0.01196867786347866, 0.011224398389458656, 0.0025282129645347595, 0.010887817479670048, 0.01219499297440052, 0.05340660363435745, -0.011531909927725792, -0.011166696436703205, 0.007149197161197662, 0.047299258410930634, -0.013455484062433243, -0.007615317590534687, 0.0170886367559433, 0.00691602099686861, -0.017192162573337555, 0.004787974525243044, 0.014846458099782467, 0.016943231225013733, -0.005116031505167484, 0.020657241344451904, -0.01946093700826168, 0.007419331930577755, 0.007845156826078892, -0.008541742339730263, 0.00015976338181644678, -0.0005833138711750507, 0.006434221751987934, 0.0008042980916798115, 0.006772723514586687, -0.0214298777282238, -0.026221197098493576, -0.00209300615824759, 0.00905737467110157, -0.006989603862166405, -0.009022556245326996, 0.018221138045191765, -0.004397829063236713, 0.021706491708755493, -0.0287025086581707, 0.0026499899104237556, -0.019154304638504982, 0.004536926280707121, -0.006883528083562851, -0.025392506271600723, -0.06710153818130493, -0.009205017238855362, -0.01556500792503357, -0.0027964902110397816, 0.007754850201308727, -0.03411533683538437, 0.011248758994042873, 0.011248772963881493, 0.0009860550053417683, 0.03069932386279106, -0.0125114182010293, -0.02422059327363968, 0.016392605379223824, -0.0026655863039195538, -0.0005209594964981079, 0.015395685099065304, -0.01674310490489006, -0.013259255327284336, 0.01990107074379921, -0.012300290167331696, -0.0020061617251485586, -0.015099050477147102, 0.0017697541043162346, 0.00805303268134594, -0.024726776406168938, -0.009137730114161968, -0.01772143691778183, 0.0020169164054095745, -0.01776251196861267, 0.0262602586299181, 0.012754077091813087, -0.027812767773866653, 0.03539470210671425, 0.002919942606240511, -0.023844044655561447, -0.009325386956334114, -0.020815381780266762, 0.016886485740542412, -0.0055886139161884785, 0.00012132804840803146, 0.012221334502100945, 0.0023855390027165413, -0.003186260350048542, 0.041903503239154816, 0.0101016815751791, -0.01733861118555069, 0.01863906905055046, -0.007540524005889893, -0.016871236264705658, 0.011922561563551426, 0.019017674028873444, -0.0008040801621973515, -0.0035809511318802834, 0.012341787107288837, 0.02341117337346077, 0.006778982933610678, 0.01354660838842392, -0.008451052941381931, 0.03976166248321533, 0.004102695733308792, -0.03254453092813492, -0.02729155123233795, -0.008453083224594593, -0.02584344521164894, -0.009748228825628757, -0.007208868395537138, 0.004315030761063099, -0.004588161129504442, 0.026036059483885765, 0.014848427847027779, -0.006093453615903854, -0.010158402845263481, -0.007750599179416895, -0.008644875138998032, -0.005100949667394161, -0.014460370875895023, 0.0010121871018782258, 0.0010124589316546917, 0.01467097457498312, 0.009313412941992283, 0.0055953217670321465, 0.006430452689528465, -0.005207539070397615, 0.005229115020483732, -0.02486378699541092, 0.023802239447832108, -0.021125104278326035, -0.01054057665169239, -0.02122456207871437, -0.011985630728304386, -0.0005176449194550514, -0.009981894865632057, -0.0018963213078677654, -0.003669031197205186, 0.012972323223948479, -0.04082842916250229, -0.005346654448658228, 0.02329656481742859, 0.009872334077954292, 0.014995715580880642, -0.0029086230788379908, -0.0014438681537285447, -0.02217022143304348, 0.013050884939730167, 0.009055638685822487, -0.003599278163164854, -0.014855992048978806, -0.017148584127426147, 0.017579732462763786, 0.009568076580762863, 0.006128076463937759, -0.014485521242022514, 0.008035317063331604, -0.019402405247092247, 0.06629449874162674, 0.015037987381219864, -0.005362255498766899, 0.00996183231472969, -0.029348403215408325, 0.022551313042640686, -0.029076024889945984, -0.00029639346757903695, -0.010291039943695068, 0.01276216097176075, 0.022228755056858063, -0.009022148326039314, 0.01018387358635664, -0.012667393311858177, 0.015334555879235268, -0.013774270191788673, 0.0033616088330745697, 0.012874445877969265, 0.011877994984388351, -0.015228455886244774, -0.00546265859156847, 0.003933226689696312, -0.011717274785041809, 0.015888791531324387, 0.008389605209231377, -0.006826350465416908, 0.010046496987342834, -0.017453398555517197, -0.01588582620024681, -0.006599235814064741, 0.028443221002817154, 0.009018025361001492, -0.003307222854346037, 0.00877696555107832, -0.013803711161017418, 0.007166930940002203, 0.00004502176307141781, -0.007362991105765104, -0.012653806246817112, -0.025959758087992668, -0.013936750590801239, 0.0008288397802971303, 0.025392191484570503, 0.0020562168210744858, 0.009173339232802391, -0.0070522502064704895, -0.007963860407471657, -0.0014648791402578354, 0.015138756483793259, 0.032535433769226074, -0.007265032269060612, -0.011484735645353794, -0.01831686496734619, -0.017574885860085487, -0.012400018982589245, 0.011672879569232464, 0.002038965467363596, 0.018225641921162605, -0.0015293192118406296, 0.024327555671334267, -0.02275167405605316, 0.0017018397338688374, 0.008180851116776466, 0.01798449084162712, 0.0063850488513708115, -0.015124179422855377, 0.014061477035284042, -0.0028970977291464806, 0.019155243411660194, 0.04753315821290016, -0.026103883981704712, 0.011496787890791893, 0.01504247821867466, -0.009608250111341476, -0.017378900200128555, 0.025297772139310837, -0.0047713154926896095, -0.004390548914670944, 0.010753353126347065, 0.02375457063317299, -0.020212626084685326, 0.006459995172917843, 0.006474384106695652, -0.0023955986835062504, -0.02923922799527645, -0.016652246937155724, -0.0008179990109056234, -0.028411488980054855, -0.015678556635975838, -0.006956225261092186, -0.0064104716293513775, 0.012765936553478241, -0.008097932673990726, -0.01107020489871502, -0.08090371638536453, -0.017283746972680092, -0.0023434055037796497, -0.004259853158146143, 0.009729007259011269, 0.0021707923151552677, 0.005680446047335863, -0.001263424288481474, -0.019929036498069763, -0.01063856203109026, -0.001956722466275096, 0.004399173893034458, -0.003905486548319459, -0.028210492804646492, 0.0020473115146160126, -0.013822849839925766, 0.01047187577933073, 0.026137791574001312, 0.0010212217457592487, -0.0213437769562006, -0.00021110218949615955, -0.0033632470294833183, 0.00746513344347477, 0.004980180412530899, -0.01863366737961769, -0.003955806605517864, 0.019130107015371323, 0.0063367257826030254, -0.02203073538839817, 0.0035814475268125534, -0.005821874365210533, -0.0002095801755785942, 0.0294199138879776, -0.010687524452805519, -0.028628990054130554, 0.0019667791202664375, 0.0005078138783574104, -0.003552006557583809, -0.03327883780002594, 0.048251673579216, -0.019765712320804596, 0.01205342635512352, 0.0033881468698382378, 0.001220465637743473, -0.0001967214047908783, -0.00795479491353035, 0.014644915238022804, -0.013349288143217564, 0.02404966950416565, -0.013022837229073048, -0.01893829181790352, 0.004748383536934853, 0.021934282034635544, 0.025815827772021294, 0.004819653462618589, -0.009955461136996746, 0.00014572171494364738, 0.03878065571188927, -0.013670315034687519, -0.013940194621682167, -0.0040816497057676315, 0.026041585952043533, 0.025614768266677856, -0.016299204900860786, 0.013300721533596516, 0.004738929681479931, 0.019569475203752518, -0.03415614739060402, -0.028281789273023605, 0.01787227764725685, 0.024121250957250595, -0.0021756889764219522, 0.004955797456204891, -0.014009835198521614, -0.024028725922107697, -0.010415454395115376, -0.017727607861161232, -0.004411633592098951, -0.009633859619498253, -0.02716793492436409, -0.022953186184167862, -0.00728212483227253, -0.0020488714799284935, 0.021525640040636063, -0.01922498270869255, -0.016654804348945618, 0.007490220479667187, 0.044532306492328644, 0.014048229902982712, -0.01720643974840641, 0.010166142135858536, 0.02072153426706791, -0.026705067604780197, 0.013568531721830368, -0.03854818642139435, -0.049777671694755554, -0.006116828881204128, -0.0035290741361677647, 0.0009342982666566968, 0.00982345174998045, -0.04056249186396599, -0.004359617829322815, -0.004085650201886892, -0.009334317408502102, -0.030913447961211205, 0.018124714493751526, -0.0059073446318507195, -0.003741320688277483, -0.007809530943632126, 0.004759011324495077, -0.009921849705278873, 0.0014745575608685613, -0.006547474768012762, -0.0005394686013460159, 0.015646062791347504, 0.03239475190639496, 0.008519169874489307, 0.002488020807504654, 0.07229872047901154, 0.018947269767522812, -0.0024057584814727306, 0.0038648643530905247, 0.013171955943107605, -0.028666339814662933, -0.016052041202783585, 0.007961800321936607, 0.013680236414074898, 0.00004659104160964489, 0.011741265654563904, -0.016198856756091118, 0.023025117814540863, 0.0038589690811932087, 0.03404397889971733, -0.015892155468463898, -0.02819235622882843, -0.012290121987462044, 0.002359076403081417, -0.01308406237512827, -0.007933528162539005, -0.03563522920012474, -0.010556759312748909, -0.03468865156173706, -0.018174681812524796, -0.008158118464052677, -0.013336244970560074, -0.015970977023243904, -0.017384270206093788, 0.014490591362118721, 0.010725026950240135, 0.031039755791425705, -0.007908521220088005, -0.01551666297018528, 0.01817546784877777, -0.003308668965473771, 0.01975017413496971, 0.01605134829878807, -0.010418451391160488, 0.0008825105614960194, -0.04238861799240112, -0.01542907115072012, 0.0008046058937907219, -0.0033310609869658947, 0.0016396250575780869, 0.01117076724767685, 0.004725739825516939, -0.013464542105793953, -0.010302282869815826, -0.035920195281505585, -0.005617642775177956, -0.00867881253361702, 0.009707344695925713, 0.023836201056838036, -0.013307142071425915, -0.009995108470320702, -0.0021089850924909115, 0.0020507918670773506, 0.018116652965545654, 0.0031600850634276867, -0.002045633736997843, 0.0029267105273902416, -0.017801638692617416, -0.021714847534894943, -0.0065108491107821465, -0.0027590712998062372, 0.008273394778370857, 0.00039724470116198063, -0.01311740092933178, -0.025350995361804962, 0.02252097800374031, -0.0011274665594100952, -0.004666140303015709, -0.004375940188765526, -0.002750738523900509, -0.0009421335998922586, 0.0035408572293817997, -0.019281752407550812, 0.0026071364991366863, 0.003888173494488001, 0.01931786723434925, 0.03783584386110306, 0.007223546504974365, 0.0019002621993422508, 0.00021370779722929, -0.0013973601162433624, -0.023076463490724564, -0.07460951805114746, -0.019307784736156464, -0.0004488809499889612, -0.004375501070171595, -0.024196259677410126, -0.0005351612344384193, -0.020993772894144058, 0.011560408398509026, 0.00840128492563963, -0.008063113316893578, 0.0020164260640740395, 0.013655251823365688, 0.010312831029295921, 0.0007565733976662159, 0.013813738711178303, 0.038209088146686554, 0.011646985076367855, 0.00784151628613472, -0.016759056597948074, 0.014613296836614609, 0.007408231496810913, -0.006969188805669546, -0.044191014021635056, 0.006892937235534191, -0.004704542923718691, -0.08090056478977203, -0.0073679662309587, 0.020885467529296875, -0.018530644476413727, 0.008950743824243546, -0.026440463960170746, 0.01385457906872034, -0.0018445218447595835, -0.004392844624817371, -0.018364978954195976, -0.011591872200369835, 0.0146118039265275, 0.03029121831059456, 0.013897613622248173, -0.0010052439756691456, -0.011441584676504135, 0.02770320698618889, -0.004084721207618713, -0.013346180319786072, 0.006385589484125376, -0.017678899690508842, 0.02770434319972992, -0.009223813191056252, -0.007004758343100548, -0.007883790880441666, -0.0003270297311246395, 0.013339015655219555, 0.014348870143294334, 0.0039092423394322395, -0.010354552417993546, -0.01637415774166584, -0.006646479479968548, -0.016634227707982063, -0.031046543270349503, 0.0001501939259469509, -0.030384160578250885, 0.01631002500653267, 0.011342888697981834, 0.01907121203839779, -0.017071347683668137, 0.0018623762298375368, 0.01860268972814083, 0.001969075296074152, -0.01566014252603054, -0.005737509578466415, -0.0077500054612755775, 0.005802088882774115, -0.0193631611764431, 0.00603144709020853, -0.012734984047710896, 0.002258715685456991, -0.010715605691075325, 0.0108504518866539, -0.009346204809844494, -0.017675738781690598, 0.01607767678797245, -0.008233120664954185, 0.005433686543256044, 0.004223381169140339, -0.001202202052809298, -0.003995261155068874, 0.024293426424264908, 0.038061439990997314, 0.07143627107143402, -0.030182834714651108, 0.003935265354812145, -0.028838111087679863, -0.015333076938986778, 0.006954238750040531, -0.03873760625720024, 0.005432917270809412, -0.003227000590413809, 0.009078730829060078, 0.011136194691061974, -0.017621858045458794, 0.0015200352063402534, 0.012531483545899391, 0.03292229026556015, -0.01047187764197588, 0.024926628917455673, -0.008986585773527622, -0.047053441405296326, 0.03140462562441826, -0.015023976564407349, -0.0021559339947998524, -0.018141956999897957, 0.010637319646775723, 0.029916122555732727, -0.012491069734096527, -0.013563205488026142, -0.0018576551228761673, -0.02351251058280468, -0.002427641535177827, 0.014725116081535816, -0.009109372273087502, -0.0011052938643842936, -0.003960008732974529, 0.013697942718863487, 0.028692107647657394, -0.010458010248839855, 0.015125559642910957, 0.0016986168920993805, 0.010858544148504734, 0.0035844710655510426, 0.023209508508443832, -0.0018354735802859068, -0.028994370251893997, 0.026787975803017616, -0.01731366291642189, 0.011502751149237156, 0.018508754670619965, -0.010380346328020096, -0.0040858350694179535, 0.0031835390254855156, 0.0017053834162652493, 0.00411108648404479, -0.007346486207097769, -0.005517466925084591, 0.00692371279001236, -0.0005799536593258381, 0.00946558266878128, 0.004747117403894663, -0.023386286571621895, 0.01582365669310093, -0.019071629270911217, 0.0035027803387492895, -0.024030223488807678, 0.015137840062379837, -0.0010483944788575172, 0.009496904909610748, -0.009733759798109531, -0.03130713105201721, 0.02008385956287384, -0.0040165213868021965, 0.0065797604620456696, 0.012843409553170204, -0.010925691574811935, 0.02920006774365902, 0.008211422711610794, 0.014650260098278522, 0.018763426691293716, 0.020172342658042908, 0.015127841383218765, -0.0027907639741897583, -0.020596949383616447, 0.0024619430769234896, 0.013957541435956955, -0.0030628815293312073, 0.005948476027697325, 0.020127885043621063, -0.010204493999481201, -0.0005864300183020532, 0.010367373935878277, 0.010176301933825016, 0.0015903899911791086, 0.0069937133230268955, 0.011167644523084164, 0.009550079703330994, 0.033134251832962036, 0.02217884361743927, 0.0025338849518448114, 0.00521779153496027, 0.0034389107022434473, 0.011555956676602364, -0.03287346661090851, -0.014390421099960804, -0.0011044039856642485, 0.018020104616880417, -0.003130808472633362, -0.02215677499771118, -0.023083176463842392, -0.016851704567670822, -0.011746796779334545, 0.002122890204191208, 0.007019092794507742, -0.009080079384148121, -0.006152177229523659, -0.003399024484679103, 0.03270750865340233, 0.0008989875204861164, -0.0038076420314610004, 0.018262475728988647, -0.018968170508742332, -0.015061883255839348, -0.01791289635002613, -0.0043511763215065, -0.008915390819311142, -0.0314323753118515, -0.01777004450559616, -0.009404846467077732, -0.007639483083039522, -0.03487443923950195, 0.003241622820496559, 0.02737586200237274, -0.004653671756386757, -0.005056130699813366, 0.028127409517765045, -0.007808332331478596, 0.011990967206656933, -0.01918671280145645, 0.024979986250400543, -0.00571298087015748, -0.008848404511809349, 0.01958954520523548, -0.010379722341895103, -0.0016888210084289312, 0.01924213021993637, 0.008955221623182297, -0.020808231085538864, 0.013720272108912468, -0.025274695828557014, 0.00930764526128769, 0.0134589783847332, 0.0026600034907460213, 0.00380542129278183, 0.005476105026900768, -0.009874975308775902, 0.027461562305688858, 0.018578797578811646, 0.003670772071927786, 0.0008176511619240046, -0.010232396423816681, -0.010209700092673302, -0.024711549282073975, 0.010675621218979359, 0.003001355566084385, -0.00020089838653802872, 0.011951062828302383, 0.008053730241954327, -0.007026230450719595, 0.014570167288184166, -0.0033843684941530228, -0.0072555202059447765, 0.019828781485557556, 0.003213373012840748, 0.01241599302738905, -0.0048124296590685844, -0.0171145498752594, -0.010988329537212849, -0.008326995186507702, -0.015348995104432106, -0.0057129161432385445, 0.0148520078510046, 0.010827407240867615, 0.003527147462591529, 0.010560743510723114, -0.009100006893277168, 0.011232939548790455, -0.016780372709035873, -0.008534036576747894, 0.00048762705409899354, 0.0016966003458946943, 0.010828599333763123, -0.03242490813136101, -0.006416552700102329, 0.011603537946939468, 0.012096616439521313, -0.03373495861887932, 0.022176571190357208, 0.0008154024835675955, -0.020277921110391617, -0.003039838746190071, 0.009506359696388245, 0.009163773618638515, -0.025322727859020233 ]
[ -0.1609152853488922, 0.4020479619503021, 0.4874778687953949, 0.041876379400491714, -0.13441532850265503, 0.08967225253582001, 0.0846603587269783, -0.11886820942163467, -0.004896853119134903, -0.3564363420009613, -0.033310286700725555, 0.13380120694637299, -0.6076530814170837, 0.07739066332578659, 0.5535200238227844, 0.38806667923927307, 0.46020519733428955, 0.22818313539028168, -0.33636191487312317, -0.7143347859382629, -0.49999764561653137, -0.694575309753418, 0.7365997433662415, 0.2336159646511078, 0.042894396930933, -0.2789560854434967, 0.1929355412721634, 0.3039776682853699, -0.050042811781167984, 0.1123822033405304, 0.03566909581422806, 0.5537647008895874, 0.26243358850479126, -0.23054437339305878, -0.29064685106277466, 0.5871548652648926, -0.3854268789291382, 0.07353263348340988, -0.03572013974189758, -0.15772821009159088, -0.23380814492702484, -0.056478336453437805, 0.5056408643722534, 0.5164130330085754, -0.4709775447845459, -0.025409286841750145, -1.4516196250915527, 0.5905093550682068, -0.06998632103204727, -0.04917757958173752, 0.40528222918510437, 0.314579576253891, 0.5596435070037842, 0.19915778934955597, 0.1809854358434677, 0.2100277990102768, -1.0365853309631348, -0.11133768409490585, 0.32157230377197266, -0.5331649780273438, 0.47048869729042053, 0.0064072743989527225, -0.42319008708000183, -0.20564140379428864, -0.3039529621601105, 0.4141699969768524, -0.2840529680252075, -0.047023117542266846, -0.3256228566169739, 0.08250545710325241, 0.32346972823143005, 0.07918054610490799, -0.1573272943496704, 0.10124324262142181, -0.4022699296474457, 0.30846482515335083, -0.29796093702316284, -0.06143363565206528, -0.11866398900747299, 0.22021688520908356, 0.4384516179561615, 0.26137587428092957, 0.5330855250358582, 0.5535123348236084, -0.10632149875164032, 0.011332964524626732, -0.011231094598770142, 0.7676686644554138, 0.2886165976524353, -0.24254010617733002, 0.24146877229213715, -0.10498890280723572, 0.7573978304862976, 0.09236013889312744, -0.225839301943779, 0.09311126172542572, 0.7010759115219116, -0.32960274815559387, 0.0811866894364357, -0.1817229837179184, -0.023728633299469948, -0.08890245109796524, -0.1318369060754776, -0.02756684087216854, 0.25190821290016174, -0.12156008183956146, -0.22440138459205627, -0.2552529573440552, -0.18545804917812347, 0.11931395530700684, -1.1884956359863281, 0.15058016777038574, -0.43369418382644653, -0.579465925693512, -0.41982144117355347, -0.019979283213615417, 0.15928605198860168, -0.40011581778526306, 0.5089365243911743, -0.25650691986083984, 0.13426834344863892, 0.41445192694664, -0.1653188169002533, 0.3111903667449951, -0.6614136099815369, -0.21446001529693604, 0.31109118461608887, 0.02662653475999832, -0.14465868473052979, 0.6649178862571716, 0.13657918572425842, 0.6736389398574829, 0.0008411858580075204, -0.2057977020740509, 0.4195777177810669, 0.19409121572971344, 0.1716398447751999, 0.16467922925949097, 0.3650541603565216, 0.14336490631103516, 0.0627313032746315, -0.8926309943199158, -0.7439062595367432, -0.03136236220598221, -0.7295310497283936, -0.18457888066768646, -0.06562213599681854, -0.10597609728574753, 0.05860418081283569, -0.6814475655555725, 0.3835773766040802, -0.02601112797856331, -0.12843182682991028, -0.023125531151890755, -0.11554970592260361, -0.3184449374675751, 0.03133884444832802, -0.6256937980651855, 0.0925830826163292, -0.2900359630584717, 0.39097732305526733, -0.4194117784500122, -0.4121767282485962, 0.06106342375278473, 0.5070344805717468, 0.15981006622314453, -0.1664762645959854, 0.2922421097755432, -0.49255433678627014, 0.36414283514022827, -0.42276883125305176, -0.35878777503967285, 0.2919727861881256, -0.6367632150650024, 0.3709573447704315, 0.5323714017868042, 0.4082587957382202, 0.21261629462242126, 0.01802939362823963, 0.23313377797603607, -0.755810558795929, 0.21077416837215424, -0.11760947108268738, -0.3698151409626007, 0.8586404919624329, 0.3633674085140228, 0.6169599294662476, -0.1187753677368164, 0.7464796900749207, -0.18985864520072937, -0.42096713185310364, -0.49690642952919006, 0.3579673171043396, -0.2353043109178543, 1.5880199670791626, -0.5991904735565186, -0.12431357800960541, 0.5230898261070251, 0.3846212923526764, 0.3309233486652374, 0.07258008420467377, -0.10295800864696503, 0.9696203470230103, -0.10885322839021683, -0.783160924911499, -0.14432647824287415, -0.02222868613898754, -0.030564304441213608, 0.049113065004348755, 0.15730054676532745, 0.5620853304862976, -0.6609329581260681, -0.24157476425170898, -0.22757023572921753, 0.2683103382587433, -0.4140245318412781, -0.5641255378723145, -0.6631797552108765, -0.8122451901435852, 0.006535458844155073, 0.4148215353488922, -0.4844045341014862, 0.3316028118133545, 0.8572635054588318, -0.05189141258597374, 0.6064936518669128, 0.6866925358772278, -0.06381075084209442, 1.0441155433654785, -1.1009284257888794, 0.5988081097602844, -0.3343845009803772, 0.04765284061431885, -0.5304071307182312, 0.17355847358703613, 0.09285922348499298, 0.44196391105651855, -0.2961609959602356, 0.2964046597480774, -0.20976120233535767, -0.0832507386803627, 0.3602847754955292, -0.8464633822441101, 0.4924233555793762, -0.1758333146572113, -0.6180191040039062, -0.6595435738563538, 0.3801482915878296, -1.329121708869934, -0.09453925490379333, 0.10360562801361084, 0.8840091824531555, -0.26370182633399963, -0.1744976043701172, 0.1314672976732254, -0.06847294420003891, 0.13873378932476044, 0.18410541117191315, -0.1267407089471817, -0.6953474283218384, -0.4043142795562744, 0.37238478660583496, 0.5593499541282654, 0.3084695637226105, 0.15355534851551056, 0.01837853714823723, -0.18134763836860657, -0.3882683217525482, 0.7507059574127197, 0.31691014766693115, 0.8323153853416443, 0.11296787112951279, -0.5842136740684509, 0.12026210874319077, -0.44377270340919495, -0.42299288511276245, -0.31074655055999756, 0.48472532629966736, -0.7140724658966064, -0.23937349021434784, -0.1265038400888443, 0.7033917903900146, 0.5483105182647705, -0.3590267300605774, -0.2887764871120453, 0.5832048058509827, -0.34404435753822327, 0.10724523663520813, -0.2190064638853073, -0.449321985244751, -0.1265707015991211, 0.2882170081138611, -0.08377522975206375, 0.13346527516841888, 0.42985835671424866, -0.011070198379456997, 0.6705203652381897, 0.9383924007415771, 0.4369066059589386, 0.26000839471817017, -0.09076272696256638, -0.21274036169052124, -0.14769577980041504, -0.13404861092567444, -0.21631328761577606, -0.3022763729095459, -0.705917477607727, 0.41247642040252686, -5.520129203796387, 0.11991038918495178, -0.08613857626914978, -0.5903517603874207, -0.16507656872272491, -0.06542711704969406, 0.8866682052612305, 0.25660040974617004, -0.2555176615715027, 0.3040362000465393, 0.22622844576835632, 0.5109683871269226, 0.03625931963324547, -0.08128688484430313, -0.5049522519111633, 0.17217516899108887, -0.6002975106239319, -0.6239164471626282, 0.17020122706890106, 0.11492124944925308, 0.3599751889705658, -0.04474277049303055, -0.425976037979126, 0.525728702545166, 0.38949230313301086, -0.026841923594474792, -1.0016000270843506, 0.48941656947135925, -0.7053031325340271, -0.28001484274864197, -0.05755316838622093, -0.6903521418571472, 0.23251263797283173, 0.15275827050209045, 0.4228694438934326, -0.10749604552984238, -0.039734985679388046, -0.159382164478302, -0.13250523805618286, -0.7168678641319275, -0.29672741889953613, -0.2904268801212311, -0.39398857951164246, 0.12439928203821182, -0.07339157164096832, -0.02857525832951069, 0.17424148321151733, 0.2580428421497345, -0.0690576508641243, 0.7626118063926697, 0.2384365200996399, -0.3109084963798523, 0.07588130980730057, 0.3874446749687195, 0.7243252396583557, 0.26134029030799866, 0.10043992847204208, -0.5564174056053162, -0.34493592381477356, -0.05591830238699913, -0.05571986734867096, -0.14380154013633728, -0.6353114247322083, -0.30445215106010437, 0.008394815027713776, 0.3742315471172333, -0.4908101260662079, -0.8428235054016113, 0.8017977476119995, 0.07329820841550827, 0.23274795711040497, 0.3729550540447235, 0.4221362769603729, -0.7603250741958618, 0.3452272415161133, -0.8983938694000244, 0.6130561232566833, 0.13806724548339844, -0.16440322995185852, -0.44162532687187195, -0.2189120650291443, -0.11363056302070618, -0.411322683095932, -0.16657313704490662, 0.3303361237049103, -0.4161461293697357, -0.5741233229637146, -0.29381486773490906, 0.13600970804691315, 0.36542561650276184, 0.5877100229263306, -0.38442039489746094, 0.31928449869155884, 0.31003013253211975, -0.06989870965480804, 0.40877634286880493, 0.2615116238594055, 0.7071468830108643, 0.4797235131263733, 0.26661133766174316, 0.45008257031440735, 0.013082101941108704, -0.37777161598205566, -0.414793998003006, -0.1393306404352188, 0.07048158347606659, -0.5389981269836426, 0.1935368776321411, 1.0093865394592285, -0.5571646690368652, 0.34585100412368774, 0.1289186328649521, 0.11535781621932983, -0.5465201139450073, 0.49809375405311584, -0.1690189242362976, -0.2005319744348526, 0.09254354238510132, 0.7401828765869141, -0.5486558675765991, 0.31103673577308655, 0.5107342600822449, -0.7104716897010803, -0.039519477635622025, -0.03942066803574562, 0.6953986287117004, 0.26542380452156067, 0.8299157023429871, -0.8165372610092163, 0.13176476955413818, 0.190829798579216, 0.24909308552742004, 0.050124458968639374, 0.319321870803833, 0.2121068835258484, -0.6404047608375549, 0.2271709144115448, 0.46491456031799316, 0.5733956098556519, 0.0209317859262228, 0.05287465825676918, -0.1842067390680313, -0.09873737394809723, -0.23262779414653778, 0.7771549224853516, 0.05646281689405441, -0.43063536286354065, -0.07661302387714386, -0.2322973757982254, 0.2943333685398102, 0.5109429955482483, -0.41805383563041687, -0.19186168909072876, 0.26689040660858154, -0.8812943696975708, 0.40929606556892395, 0.00028138962807133794, 0.09094958007335663, 0.5611291527748108, -0.5499287843704224, 0.6801623702049255, -0.20904742181301117, -1.3291531801223755, -0.48455777764320374, -0.459629625082016, -0.13830819725990295, -0.09779141843318939, -0.8082630634307861, -0.23953595757484436, 0.13022352755069733, -0.22806888818740845, 0.08246246725320816, -0.26287126541137695, -0.33680710196495056, 0.07484570145606995, -0.483085960149765, -0.5962035059928894, 0.39602044224739075, 0.3501628339290619, 0.1964247077703476, 0.08109571784734726, -0.26036128401756287, -0.18396437168121338, 0.6321535110473633, 0.7626228332519531, -0.318495512008667, 0.4225233197212219, -0.4463166892528534, -0.2421182245016098, -0.26048266887664795, 0.4173465371131897, 0.1591050773859024, 0.19251748919487, -0.15329311788082123, 0.10028933733701706, 0.1377216875553131, -0.2868421971797943, 0.024304773658514023, -0.27346736192703247, 0.0743609145283699, -0.17566445469856262, 0.6538045406341553, 0.008934307843446732, 0.22889280319213867, 0.579007089138031, 0.08348540961742401, -0.19533126056194305, -0.37278303503990173, -0.7592791318893433, -0.11503133177757263, 0.39408934116363525, -0.4327927827835083, -0.01979905739426613, 0.11760366708040237, -0.4855370819568634, 0.09940695762634277, 0.2164139449596405, -0.4728759527206421, -0.5284181237220764, -0.047439511865377426, 0.6499589085578918, 0.45959678292274475, -0.1146615520119667, -0.22319386899471283, -0.4881804883480072, -0.3142516613006592, 0.20021112263202667, -0.5626683235168457, 0.35684797167778015, -0.24164101481437683, -0.6243460178375244, 0.013661597855389118, 0.058448806405067444, -0.3252730965614319, -0.5676367282867432, -0.4904712736606598, -0.23692286014556885, 0.29213133454322815, -0.2141030877828598, 0.4329415261745453, 0.3421022295951843, 0.6474432945251465, -0.15469962358474731, -0.2590014338493347, -0.14998698234558105, 0.4952337145805359, 0.15529540181159973, -0.714215099811554, -0.4012645184993744, 0.00806718971580267, 0.4346240758895874, 0.003076642518863082, -0.000105738450656645, 0.27142372727394104, 0.8591549396514893, 0.5064672827720642, 0.41157811880111694, -0.7779110670089722, -0.1471552550792694, -0.0008730397676117718, 0.07950224727392197, -0.23513095080852509, -0.45992210507392883, 0.4433693289756775, 0.022480124607682228, 0.33939412236213684, -0.033819232136011124, -0.7103179693222046, 0.2094663381576538, -0.4158783257007599, 0.10316698998212814, 0.0736144632101059, 0.2875312268733978, 0.287375807762146, 0.12751397490501404, 0.4779323637485504, -0.49206671118736267, -0.5641316175460815, 0.21989032626152039, 0.26565101742744446, -0.019519254565238953, -0.6348622441291809, 0.23039685189723969, 0.1284683644771576, 0.41099482774734497, -0.8326300382614136, 0.41958457231521606, -0.22469031810760498, -0.4015499949455261, -0.3175103962421417, -0.2159520983695984, 0.35388731956481934, -0.42082473635673523, -0.17830371856689453, 0.1888444572687149, 0.000803861184976995, -0.17594212293624878, 0.16540898382663727, -0.3360074758529663, -0.42061084508895874, -0.7126467227935791, 0.43527838587760925, 0.5787829160690308, -0.34025493264198303, 0.27285054326057434, 0.2308320850133896, -0.014516640454530716, -0.600691020488739, -0.5466389656066895, -0.36025041341781616, 0.5360174179077148, -0.2443993091583252, -0.24720516800880432, 0.3244127035140991, 0.5515275597572327, 0.314874529838562, -0.4477088451385498, 0.5049625635147095, 0.20649570226669312, 0.3053213953971863, 0.6545578837394714, 0.7524968385696411, 1.0549782514572144, -0.22401948273181915, -0.1878753900527954, 0.1761622577905655, -0.23951633274555206, 0.6192243099212646, 0.48643845319747925, 0.7237102389335632, 0.7311966419219971, 0.10209131985902786, -0.1466747224330902, 0.713964581489563, 0.5647917985916138, 0.07194336503744125, -0.16215915977954865, -0.8189578652381897, -0.4104689359664917, -0.6770961880683899, 0.6940068602561951, 0.7680771350860596, 0.4879657030105591, 0.28979986906051636, 0.4792913496494293, 0.7112937569618225, -0.05166412144899368, 0.3491632640361786, -0.07380174845457077, -0.7661529779434204, 0.3242384195327759, -0.43626007437705994, -0.48565226793289185, -0.6461447477340698, -0.5741796493530273, 0.8113089203834534, 0.41869476437568665, -0.23668763041496277, -0.29252031445503235, 0.497793972492218, -0.4984644949436188, -0.23349593579769135, -0.24063527584075928, 0.37795543670654297, -0.05186830088496208, 0.17625702917575836, 0.3135286271572113, -0.23822803795337677, 0.7482027411460876, -0.3875516355037689, -0.348478764295578, 0.24427209794521332, -0.39739012718200684, 0.23651160299777985, 0.3355751037597656, -0.6314923167228699, 0.130409374833107, 0.2163257747888565, 0.10987803339958191, 0.10224787890911102, -0.3730996549129486, 0.052436619997024536, -0.3507583439350128, -0.46672648191452026, 0.35963088274002075, -0.45193129777908325, 0.045427799224853516, -0.08365408331155777, 0.36227744817733765, 0.00021466758335009217, -0.19423671066761017, -0.4505321681499481, 0.26505860686302185, -0.023986930027604103, 0.6907066106796265, -0.5087106823921204, -0.10247094929218292, 0.15824683010578156, 0.22624118626117706, 0.12655383348464966, -0.08094507455825806, -0.3757867217063904, -0.1953003853559494, 0.3180829584598541, -0.8951280117034912, 0.5662906169891357, -0.18612085282802582, 0.11019714176654816, -0.39408665895462036, 0.45322349667549133, 0.6924425959587097, 0.7199773788452148, -0.26510289311408997, 0.6328089237213135, 0.3661097586154938, -0.06738870590925217, -0.023644378408789635, -0.35966676473617554, -0.7756868600845337, -0.627313494682312, -0.4186493158340454, -0.1339341551065445, 0.7447705268859863, -0.09637628495693207, -0.47126901149749756, 0.13991086184978485, 0.37013864517211914, 0.2983512878417969, -0.014472720213234425, -0.14255300164222717, -0.44774240255355835, 0.2650417685508728, -0.9502518773078918, 0.4172539710998535, -0.43286824226379395, 0.17432384192943573, -0.17015451192855835, -0.31949949264526367, -0.42218291759490967, 0.020997166633605957, 0.1369800567626953, -0.4978932738304138, -0.19590851664543152, -0.07263290137052536, 0.43826577067375183, 0.16700662672519684, 0.07834034413099289, -0.5432420372962952, -0.7659764885902405, 0.23842686414718628, 0.3932037055492401, -0.9290463328361511, -0.2106722891330719, -0.20070511102676392, 0.11377371847629547, 0.14043934643268585, -0.43652117252349854, 0.04352695867419243, -0.38125935196876526, 0.020776938647031784 ]
Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum. However, the omental stromal cell-derived molecular determinants that modulate ovarian cancer growth have not been characterized. Here, using next-generation sequencing technology, we identify significantly higher levels of microRNA-21 (miR21) isomiRNAs in exosomes and tissue lysates isolated from cancer-associated adipocytes (CAAs) and fibroblasts (CAFs) than in those from ovarian cancer cells. Functional studies reveal that miR21 is transferred from CAAs or CAFs to the cancer cells, where it suppresses ovarian cancer apoptosis and confers chemoresistance by binding to its direct novel target, APAF1. These data suggest that the malignant phenotype of metastatic ovarian cancer cells can be altered by miR21 delivered by exosomes derived from neighbouring stromal cells in the omental tumour microenvironment, and that inhibiting the transfer of stromal-derived miR21 is an alternative modality in the treatment of metastatic and recurrent ovarian cancer.
[ -0.009562088176608086, 0.0017190971411764622, -0.007650233805179596, 0.012796164490282536, 0.00515552144497633, 0.0004962068051099777, 0.011599157936871052, 0.019774185493588448, -0.011520246043801308, -0.01505924854427576, 0.0008233962580561638, 0.005465866066515446, -0.0031710434705018997, 0.012883705087006092, -0.0012880773283541203, 0.006405835039913654, -0.020888160914182663, -0.023740213364362717, 0.013879073783755302, 0.03037322871387005, 0.022551847621798515, -0.029778391122817993, 0.010480480268597603, 0.02025170996785164, -0.006593998521566391, 0.018951065838336945, -0.00958683155477047, -0.005911671090871096, -0.004246248863637447, 0.012274559587240219, -0.02254227176308632, -0.008480187505483627, 0.006877639330923557, -0.007829231210052967, -0.015711847692728043, -0.028404301032423973, -0.009049803018569946, 0.01966223120689392, 0.00564850028604269, -0.004703162238001823, 0.01945214346051216, -0.015391799621284008, 0.005974961444735527, 0.011144749820232391, -0.007096275687217712, -0.0007732663070783019, -0.0025588448625057936, -0.024139489978551865, 0.0011679856106638908, 0.004670688882470131, -0.009647183120250702, -0.00033967895433306694, -0.011953133158385754, 0.017861690372228622, -0.006852714344859123, -0.008944666013121605, 0.019412193447351456, -0.025595415383577347, -0.018876591697335243, 0.005709595046937466, -0.011540882289409637, -0.02522321045398712, -0.020111242309212685, -0.021223396062850952, -0.007186780218034983, -0.06642256677150726, 0.031067296862602234, -0.003732826095074415, -0.006781953386962414, -0.010590313002467155, 0.01941634900867939, 0.009285712614655495, 0.01417449489235878, -0.0008706888183951378, -0.014454169198870659, -0.007076488807797432, 0.0014461438404396176, -0.014852935448288918, 0.006225334946066141, 0.014580943621695042, -0.02133462391793728, -0.0020402800291776657, -0.022088244557380676, 0.003437582403421402, -0.009341591037809849, 0.010535791516304016, -0.02910071797668934, 0.011099813506007195, 0.018674753606319427, 0.009402896277606487, -0.0040820082649588585, 0.013778092339634895, -0.02015361189842224, 0.00521469209343195, -0.023951025679707527, 0.0018223118968307972, -0.006548940669745207, -0.009648792445659637, 0.03525532782077789, -0.0067046466283500195, -0.017640549689531326, 0.010400482453405857, 0.016423625871539116, -0.024964753538370132, -0.006228076294064522, 0.008181066252291203, 0.014248114079236984, -0.012226826511323452, 0.02444153092801571, 0.008091874420642853, -0.003920144401490688, -0.00775119848549366, 0.006368165835738182, 0.010291232727468014, 0.00416785990819335, -0.020543232560157776, -0.0011428787838667631, 0.009069520980119705, 0.006185198202729225, 0.0006415238603949547, 0.012751728296279907, 0.0016904864460229874, -0.006255086977034807, 0.014722753316164017, 0.0047621047124266624, -0.0011407239362597466, -0.010644414462149143, -0.007389371283352375, 0.0031189413275569677, -0.006114139221608639, -0.006245163735002279, 0.011020932346582413, 0.010027827695012093, -0.010688355192542076, -0.028115205466747284, 0.007779296487569809, -0.002396076451987028, -0.03828451782464981, -0.013024980202317238, -0.02626865729689598, 0.004384578205645084, 0.0039958348497748375, 0.0029718545265495777, 0.007158207707107067, 0.024256683886051178, 0.006663572508841753, -0.016290996223688126, -0.004755059722810984, -0.010423781350255013, -0.0013807902578264475, 0.015731606632471085, -0.014733313582837582, -0.01934591308236122, -0.013435781933367252, 0.04124009609222412, -0.010986864566802979, -0.01767897605895996, -0.0017719841562211514, 0.008166581392288208, -0.007064924109727144, -0.01399320550262928, -0.018712982535362244, -0.005254274234175682, 0.012183591723442078, 0.022726580500602722, 0.0009553655982017517, -0.012763332575559616, 0.009820331819355488, 0.02573310025036335, 0.00610855408012867, -0.008761806413531303, -0.004369914531707764, 0.0076645053923130035, 0.0071952976286411285, 0.011076005175709724, 0.01196769904345274, -0.0046967193484306335, 0.00508184265345335, -0.01602262817323208, 0.06583502888679504, -0.008264252915978432, 0.012821359559893608, -0.00017781415954232216, 0.011994929984211922, 0.01132212858647108, -0.013276833109557629, 0.021518703550100327, -0.001852505374699831, -0.0030796686187386513, 0.012656325474381447, 0.002610567258670926, -0.0007732943631708622, -0.016564713791012764, 0.012890545651316643, -0.05314764380455017, 0.0027469280175864697, 0.01399200689047575, 0.006590479053556919, 0.004538440611213446, -0.01874610036611557, 0.012588175013661385, 0.0014909449964761734, 0.0035625214222818613, 0.007179887965321541, 0.021413933485746384, 0.00978324469178915, 0.003859657794237137, -0.03081621415913105, 0.0005553131923079491, -0.0076522245071828365, 0.02411850169301033, 0.0013113864697515965, 0.010783784091472626, -0.02564636990427971, 0.010169701650738716, -0.012143042869865894, -0.005808540619909763, 0.018918093293905258, 0.0002717268653213978, -0.012825557962059975, -0.001159444684162736, 0.020701438188552856, 0.013971470296382904, 0.022397110238671303, 0.014394792728126049, -0.023478826507925987, 0.009519321843981743, 0.008859511464834213, -0.0010744621977210045, -0.0056477137841284275, -0.00963406078517437, -0.031795989722013474, -0.012719410471618176, 0.0021775811910629272, -0.0029826778918504715, -0.006614214275032282, 0.01306435838341713, -0.01234563160687685, 0.0030296901240944862, -0.013512427918612957, 0.006563541945070028, 0.0016121652442961931, 0.009569451212882996, -0.02098679728806019, -0.014622067101299763, 0.010833862237632275, 0.0285816490650177, 0.013447321020066738, 0.02916610613465309, 0.0023466283455491066, 0.0047796545550227165, -0.01596939191222191, 0.010543456301093102, -0.00251988647505641, 0.011346281506121159, -0.005444657057523727, -0.011898016557097435, 0.014688252471387386, 0.02666347846388817, -0.023584067821502686, -0.0026298819575458765, 0.005258909426629543, -0.012546053156256676, -0.01049414835870266, 0.0009514703415334225, 0.04588086158037186, -0.00009709782898426056, 0.007342059165239334, 0.021140241995453835, -0.007286109495908022, 0.012856345623731613, -0.003952531609684229, 0.0065814959816634655, -0.08085803687572479, -0.013019607402384281, 0.0246681310236454, -0.014487160369753838, 0.00624514976516366, 0.0007396468427032232, -0.0014213803224265575, 0.008740360848605633, -0.00017769797705113888, -0.014028290286660194, 0.008818451315164566, 0.00668103713542223, -0.004243461415171623, -0.02210209146142006, 0.016889188438653946, -0.00001871644053608179, 0.013649421744048595, 0.0063982149586081505, -0.01636589877307415, -0.02534763142466545, -0.01829634979367256, 0.0018675215542316437, 0.005721960216760635, 0.01747286133468151, -0.01601441204547882, 0.014690627343952656, -0.0024472801014781, -0.010782312601804733, -0.0034958370961248875, 0.006692441180348396, -0.02609425038099289, -0.0054455166682600975, 0.01740708202123642, 0.002849200740456581, 0.00757561856880784, 0.0030552027747035027, 0.0007606567814946175, -0.028406811878085136, -0.017442764714360237, 0.021181657910346985, -0.0034994864836335182, 0.007788559887558222, 0.026681916788220406, -0.005539170000702143, 0.009300442412495613, 0.003412888152524829, -0.00454319454729557, 0.006591806188225746, 0.023889675736427307, -0.018108027055859566, 0.015112517401576042, 0.015791401267051697, 0.007081351708620787, 0.015934081748127937, -0.02094818651676178, -0.02065255306661129, -0.04281507804989815, -0.01157646719366312, -0.00994653906673193, -0.009652292355895042, 0.04913599044084549, -0.029667919501662254, 0.0176483616232872, 0.008388745598495007, -0.014492850750684738, 0.014805669896304607, 0.022260356694459915, 0.01477908156812191, -0.004648273810744286, 0.016669191420078278, -0.0029057087376713753, -0.016011876985430717, -0.013864257372915745, -0.0060601020231842995, -0.0038562053814530373, -0.012551333755254745, -0.011971607804298401, -0.005452106706798077, 0.007591900881379843, -0.004750790074467659, -0.000395550683606416, -0.00988006591796875, 0.005702652968466282, 0.0025008239317685366, -0.029452672228217125, 0.005286822095513344, 0.005693638231605291, 0.05422237515449524, 0.004899251274764538, -0.012787917628884315, -0.006967089604586363, 0.04236628860235214, 0.031762056052684784, 0.011159957386553288, 0.025507470592856407, 0.010602787137031555, 0.012022046372294426, -0.010459220968186855, 0.02780517190694809, 0.0083639957010746, -0.022634025663137436, -0.008126785978674889, 0.0012423184234648943, -0.003157694824039936, -0.03499266877770424, 0.017905373126268387, 0.010796572081744671, -0.021455805748701096, 0.007389692589640617, 0.005378232337534428, -0.021180827170610428, -0.004984617233276367, -0.005812511313706636, 0.009100746363401413, 0.010214794427156448, 0.010035794228315353, -0.024555053561925888, -0.00909554585814476, 0.07122160494327545, 0.022367866709828377, -0.0025035953149199486, -0.012798392213881016, 0.010783461853861809, -0.04328412562608719, -0.013457246124744415, 0.016853660345077515, -0.014177731238305569, -0.005187247879803181, 0.013875380158424377, -0.02701760083436966, 0.001364290714263916, 0.006109927780926228, -0.03197038173675537, 0.008679167367517948, 0.013383276760578156, 0.0026025394909083843, 0.013510051183402538, 0.00798628106713295, -0.00954324472695589, 0.013610819354653358, -0.0025535705499351025, 0.0018662840593606234, -0.0033955585677176714, -0.02621854841709137, 0.016098111867904663, -0.013612796552479267, -0.02221595123410225, 0.010850708931684494, 0.00704531092196703, 0.00517170038074255, -0.009355537593364716, -0.016348514705896378, 0.013226918876171112, 0.0052914610132575035, -0.011690465733408928, -0.009310789406299591, 0.010843466967344284, -0.03294474631547928, -0.01445971243083477, -0.012515388429164886, 0.0076263900846242905, 0.009318958036601543, 0.0012944614281877875, 0.008781294338405132, 0.030252741649746895, -0.0056727007031440735, -0.0030890577472746372, -0.01639174297451973, -0.0017518121749162674, -0.003348479513078928, 0.010684063658118248, 0.00793505646288395, -0.019638104364275932, -0.006314429920166731, 0.013506947085261345, 0.004532411694526672, -0.014980899170041084, -0.0015156680019572377, 0.017990414053201675, 0.012844011187553406, 0.007401939015835524, -0.002994644921272993, 0.01769455522298813, -0.02453228272497654, 0.005752637516707182, 0.006530306302011013, 0.013276721350848675, -0.023893095552921295, 0.023222725838422775, 0.009697075933218002, -0.013376109302043915, 0.0031509152613580227, -0.033307891339063644, 0.019040927290916443, -0.010379048064351082, -0.00900366622954607, 0.037814997136592865, -0.01464909315109253, -0.022787196561694145, 0.0028883167542517185, -0.015126042999327183, -0.016239136457443237, -0.018707040697336197, -0.024193238466978073, -0.006429148837924004, -0.07441263645887375, 0.005497370380908251, -0.00723513588309288, -0.0016381556633859873, 0.013738034293055534, 0.021794632077217102, -0.006646658293902874, 0.017601128667593002, -0.001335372100584209, -0.008946238085627556, 0.019234396517276764, 0.012554783374071121, 0.02343032881617546, -0.006973637267947197, 0.010781851597130299, -0.006890847347676754, 0.010372845456004143, -0.002941608428955078, -0.014455756172537804, 0.021255776286125183, 0.013463800773024559, 0.028962429612874985, -0.0028334762901067734, -0.0010926309041678905, -0.012774085626006126, -0.08021591603755951, 0.010190911591053009, 0.006419554352760315, -0.0054205176420509815, 0.0019921613857150078, -0.0018476422410458326, -0.007943674921989441, 0.010187620297074318, 0.02790345624089241, -0.015939384698867798, 0.005993228405714035, -0.010900677181780338, -0.0014745679218322039, -0.00930835586041212, -0.00964952353388071, -0.01058556791394949, 0.011840831488370895, 0.007179569453001022, -0.022550536319613457, 0.01608731970191002, 0.0012693940661847591, 0.01603054627776146, -0.005669800564646721, 0.006993511691689491, -0.005419144872575998, -0.002783259842544794, -0.007933210581541061, 0.010139819234609604, 0.006767164915800095, -0.007917972281575203, -0.007754688151180744, -0.015871718525886536, -0.009110897779464722, -0.0025455886498093605, 0.01083239447325468, -0.017234470695257187, 0.011202357709407806, 0.0019096005707979202, 0.0049030533991754055, 0.0008140022400766611, -0.008207255974411964, 0.012451207265257835, -0.02447899989783764, -0.018535954877734184, -0.012801587581634521, -0.01475491188466549, 0.008044198155403137, -0.006530774757266045, -0.00037027965299785137, -0.007094064727425575, 0.008963195607066154, -0.0023148907348513603, -0.006832929793745279, 0.011588793247938156, -0.012905288487672806, 0.01921238750219345, 0.000005823676474392414, 0.029040364548563957, 0.013895926997065544, 0.010858362540602684, -0.0072656553238630295, 0.02092095836997032, -0.007667116820812225, 0.07067382335662842, 0.02123197354376316, -0.005510428920388222, -0.005352102220058441, -0.007259777747094631, 0.011259917169809341, -0.04225558787584305, -0.00958307459950447, 0.0029804056975990534, -0.007874244824051857, 0.008976448327302933, 0.002720013726502657, 0.01326065044850111, 0.015469815582036972, 0.022253064438700676, 0.016128450632095337, 0.0002837604843080044, -0.003923715557903051, 0.01510829757899046, 0.012274245731532574, -0.01983966864645481, 0.021750394254922867, -0.005099209025502205, -0.0230151005089283, 0.0034070569090545177, -0.008276553824543953, -0.021680831909179688, 0.020864300429821014, -0.0000744090648368001, 0.014689886942505836, 0.0034435540437698364, 0.0038093626499176025, 0.0034755452070385218, -0.01728926971554756, 0.02155664749443531, 0.02249658852815628, 0.013958100229501724, 0.010113595053553581, -0.02555411495268345, 0.0010165499988943338, 0.020314229652285576, -0.00009232433512806892, -0.0030553308315575123, 0.026024382561445236, 0.030719628557562828, -0.004198363982141018, -0.005379917100071907, -0.019847258925437927, -0.008997882716357708, 0.00591908348724246, 0.007887369953095913, 0.004614519886672497, 0.012535704299807549, -0.020841948688030243, -0.011095700785517693, 0.015773680061101913, 0.0012482097372412682, 0.02259100042283535, -0.022535007447004318, -0.004054407123476267, 0.02214399166405201, -0.01842544786632061, 0.021476127207279205, -0.02294876053929329, 0.0003010174259543419, -0.03409173712134361, 0.01736217550933361, -0.021708078682422638, -0.005886607337743044, 0.01870759017765522, 0.005966034717857838, 0.0023197527043521404, 0.006496731657534838, 0.013259585946798325, 0.01133813988417387, -0.005961755756288767, 0.03535126894712448, 0.019995395094156265, 0.010506297461688519, 0.022954054176807404, -0.01033379603177309, 0.02205255627632141, -0.005391544662415981, -0.026706891134381294, -0.0168108269572258, 0.01805976964533329, 0.005466780625283718, -0.021074574440717697, -0.001963281072676182, 0.00870221946388483, 0.014128540642559528, 0.01976536028087139, 0.00696914829313755, 0.022154880687594414, 0.007677879184484482, 0.034804366528987885, 0.011239075101912022, 0.0012382450513541698, 0.0026828795671463013, 0.02557830698788166, 0.014869536273181438, 0.006437128409743309, -0.020177489146590233, 0.005576791241765022, -0.023419732227921486, -0.0005482970736920834, 0.026785805821418762, 0.000542817753739655, -0.01719995215535164, 0.028869137167930603, 0.018224146217107773, -0.008778976276516914, -0.0015763852279633284, -0.003579137846827507, -0.0017000326188281178, 0.02240457758307457, -0.011950431391596794, -0.008391241542994976, 0.004448688589036465, -0.01790209859609604, 0.019981255754828453, -0.0006902702152729034, 0.009557802230119705, 0.006395667791366577, -0.002008097479119897, -0.02028340846300125, -0.004208516329526901, 0.016205724328756332, -0.007990741170942783, -0.037951044738292694, 0.011551635339856148, 0.020144743844866753, -0.006946143694221973, 0.00666374247521162, -0.018039699643850327, -0.02354324795305729, -0.0011292025446891785, -0.017052553594112396, -0.010205928236246109, 0.018330181017518044, -0.007942937314510345, -0.009138152003288269, -0.0030028175096958876, -0.0011332654394209385, 0.009191421791911125, 0.008248908445239067, 0.023439016193151474, -0.015351522713899612, 0.017313774675130844, 0.01840759441256523, -0.0015809419564902782, 0.010172627866268158, 0.02141588367521763, -0.0025760650169104338, -0.02186748757958412, 0.008902831003069878, 0.004808105528354645, 0.020787924528121948, 0.017955180257558823, -0.011126775294542313, 0.001099398359656334, 0.019509950652718544, -0.008250292390584946, 0.0003548320382833481, 0.014475198462605476, 0.0027378229424357414, 0.009924954734742641, 0.021099580451846123, 0.006003674119710922, 0.006907160859555006, -0.013881683349609375, -0.010318860411643982, -0.026701610535383224, 0.028975307941436768, -0.02737022377550602, 0.0030832320917397738, -0.017524532973766327, -0.018039900809526443, -0.010540437884628773, -0.007957854308187962, -0.008238502778112888, -0.012489610351622105, 0.00671094935387373, -0.007607764098793268, -0.003922594711184502, -0.0021530098747462034, -0.003807676723226905, 0.012013636529445648, 0.004339404404163361, 0.004594409838318825, -0.012431365437805653, 0.013647220097482204, -0.0008017747895792127, 0.016088254749774933, -0.025595393031835556, 0.01575503498315811, 0.01913493126630783, 0.0038315230049192905, -0.010501359589397907, 0.0063417647033929825, -0.010401779785752296, -0.006077816244214773 ]
[ -0.4619836211204529, 0.02360089123249054, 0.24221014976501465, -0.08394771814346313, 0.7010729312896729, 0.663622260093689, 0.006405407562851906, 0.08789636939764023, 0.23996174335479736, -0.4213367998600006, 0.0893566682934761, 0.079773910343647, 0.08149641752243042, 0.14899253845214844, -0.10822498053312302, 0.342154860496521, 0.3492494821548462, 0.42247670888900757, -0.05336591228842735, -0.4667430818080902, -0.3114512860774994, -0.16472338140010834, 0.828871488571167, 0.14986903965473175, 0.13922648131847382, -0.7320322394371033, 0.21656236052513123, 0.1946624517440796, 0.2887643277645111, -0.4843989908695221, -0.8736523985862732, 0.2415962517261505, 0.26235002279281616, -0.2956065833568573, -0.1993468999862671, -0.2884770631790161, -0.12481316924095154, -0.09025771915912628, -0.1909039467573166, -0.2413155734539032, -0.7614511847496033, -0.1869966983795166, 0.12904329597949982, 0.62047278881073, -0.36622974276542664, -0.21535156667232513, -1.5015020370483398, 1.013386845588684, -0.14106714725494385, 0.3810446560382843, 0.27741748094558716, 0.05662396177649498, 0.5054041147232056, -0.1479240208864212, 0.3404686152935028, 0.09192176908254623, -0.502795398235321, 0.18519863486289978, 0.21300935745239258, -0.5201685428619385, 0.13590089976787567, 0.005675524473190308, -0.24788683652877808, 0.1504637897014618, 0.17949308454990387, 0.4908601939678192, -0.026092082262039185, -0.6463636159896851, -0.5138246417045593, -0.4192672073841095, 0.09685365855693817, -0.6032649874687195, -0.016789082437753677, 0.4701141119003296, -0.2764967679977417, 0.045676134526729584, -0.47001445293426514, -0.17410065233707428, 0.3866359293460846, -0.20956751704216003, 0.019937779754400253, 0.34013986587524414, 0.1606181561946869, 0.20110799372196198, 0.47665920853614807, 0.2539443373680115, -0.11876960843801498, 0.685442328453064, -0.6707627773284912, -0.12038524448871613, -0.45336276292800903, -0.10245908051729202, 0.530481219291687, 0.4361989498138428, 0.4882873594760895, 0.037218984216451645, 0.15666763484477997, 0.0816083773970604, -0.05372507497668266, -0.10098399966955185, -0.5987936854362488, 0.4106290936470032, 0.25479766726493835, -0.6774893403053284, -0.6815645694732666, -0.15351489186286926, 0.15600715577602386, -0.17668189108371735, -0.6250013709068298, -0.02667202427983284, -1.0170338153839111, 0.3447771668434143, -0.16402886807918549, -0.011077559553086758, 0.051127735525369644, 0.5608941912651062, -0.12382649630308151, -0.6581793427467346, -0.2254309356212616, -0.28070351481437683, -0.1740458905696869, 0.9316878318786621, -0.30307674407958984, 0.6060363054275513, 0.03853822872042656, 0.219679594039917, 0.4577452540397644, 0.3247852921485901, -0.007982129231095314, 0.6005504727363586, 0.06233684718608856, 0.49678370356559753, -0.1839926689863205, 0.1018097996711731, 0.2624654173851013, -0.06843926012516022, -0.09212879091501236, 0.27525466680526733, 1.105391263961792, 0.1538712978363037, -0.7980480790138245, -0.4869178235530853, -0.1689060926437378, -0.11379534006118774, 0.13410557806491852, -0.4315306842327118, -0.124036505818367, -0.2276114970445633, -0.37435054779052734, -0.4441342353820801, 0.287352055311203, -0.23499663174152374, -0.34329479932785034, -0.011246001347899437, 0.13876411318778992, 0.4899442195892334, 0.5049432516098022, -0.48340755701065063, 0.3724880516529083, 0.4360491633415222, 0.19754911959171295, 0.15572836995124817, -0.13026615977287292, -0.11811583489179611, 0.15919367969036102, -0.33089959621429443, 0.5507258176803589, 0.13929468393325806, -0.019286710768938065, 0.5278935432434082, -0.5568711161613464, -0.21836592257022858, 0.19852076470851898, -0.41611889004707336, 0.14342689514160156, 0.03817855194211006, 0.4757162630558014, 0.1664721816778183, 0.18926337361335754, -0.1589869260787964, -0.7224094271659851, 0.4381619989871979, -0.13739493489265442, -0.020308876410126686, -0.10976091027259827, -0.5556596517562866, 0.1278361976146698, 0.22011998295783997, 0.47955524921417236, 0.19731473922729492, -0.28231462836265564, -0.45916423201560974, 0.8130335211753845, -0.055404338985681534, 1.0839124917984009, -0.2856237292289734, 0.01229142863303423, 1.2198123931884766, 0.06731678545475006, 0.01148351188749075, 0.19109228253364563, 0.13721764087677002, 0.4631868898868561, -0.2966706156730652, -0.8293551206588745, -0.07772314548492432, -0.2291913777589798, -0.4017280042171478, 0.17953257262706757, 0.05258583277463913, 0.3092094361782074, -0.09263315796852112, 0.13068976998329163, -0.38948550820350647, 0.22032617032527924, -0.09320113807916641, -0.04939787834882736, 0.24117235839366913, 0.07723910361528397, -0.25902214646339417, 0.37351560592651367, -1.028087854385376, 0.8845361471176147, 0.4219946563243866, 0.12966470420360565, 0.5799350738525391, 0.4266234338283539, -0.12741269171237946, 0.8930864930152893, 0.007385415956377983, 0.30661526322364807, -0.27654799818992615, 0.062831349670887, -0.35932615399360657, -0.09718029946088791, 0.3698168098926544, -0.05010956525802612, -0.13375234603881836, 0.19341826438903809, -0.09180235117673874, 0.027674535289406776, 0.35196682810783386, -0.6874744296073914, -0.20731796324253082, 0.33783555030822754, -0.351473331451416, -0.42430785298347473, -0.17299188673496246, -0.8984816670417786, -0.07108686119318008, -0.38707342743873596, -0.056075938045978546, -0.1644314080476761, -0.35183700919151306, 0.00449514202773571, -0.0717303603887558, -0.2754311263561249, 0.08515763282775879, 0.39822542667388916, -0.45546358823776245, -0.18283577263355255, 0.13282087445259094, 0.12545588612556458, 0.9352390170097351, 0.28453531861305237, 0.08389586210250854, -0.5582690834999084, -1.1418123245239258, 0.9333106875419617, 0.39339837431907654, 0.48324769735336304, 0.5320484042167664, -0.7094517946243286, -0.20289160311222076, -0.2782462537288666, -0.9095370173454285, -0.379908949136734, 0.3412594795227051, -0.41065946221351624, -0.3449610471725464, 0.3550173044204712, 0.5620689392089844, 0.8047966957092285, -0.03273816034197807, -0.4318713843822479, 0.2804624140262604, -0.00011876646021846682, -0.22308184206485748, -0.44517144560813904, -0.15438757836818695, -0.21322192251682281, -0.03183732181787491, -0.87742680311203, 0.33929362893104553, 0.5473184585571289, -0.013900026679039001, 0.1959134042263031, 0.29713502526283264, 0.41744163632392883, -0.10162341594696045, -0.14808236062526703, 0.10392405092716217, -0.21881774067878723, -0.2018011510372162, -0.3013467788696289, -0.13403475284576416, -0.019311683252453804, 0.1310606747865677, -5.71533203125, 0.10395340621471405, -0.25081974267959595, -0.45051831007003784, 0.04785594344139099, -0.20934335887432098, 0.1762484312057495, -0.32717204093933105, 0.38659483194351196, -0.18910421431064606, 0.1256101131439209, 0.6468798518180847, -0.11357031017541885, -0.21135488152503967, -0.47954195737838745, -0.09581930190324783, -0.6251851916313171, 0.08331842720508575, 0.3901781141757965, -0.17622295022010803, 0.25996455550193787, -0.4496288001537323, -0.2738238573074341, 0.8704570531845093, 0.12191202491521835, 0.21383827924728394, -0.47699880599975586, 0.1826343983411789, -0.3450392484664917, -0.7932873964309692, -0.14539934694766998, -0.5369693636894226, 0.30916139483451843, 0.3077453672885895, 0.10641752928495407, 0.4133821725845337, 0.4648195505142212, 0.18954125046730042, 0.4066755771636963, -0.4419724941253662, 0.3203279674053192, 0.08897513896226883, -0.1611935943365097, 0.03990573808550835, 0.18335247039794922, -0.3209287226200104, 0.04763033613562584, 0.6435227394104004, -0.3013734817504883, 0.919766366481781, -0.13269385695457458, -0.1711210012435913, 0.3033170700073242, 0.822422981262207, 0.34428226947784424, 0.559878945350647, -0.4105498194694519, 0.0041414122097194195, 0.08478612452745438, -0.22381308674812317, -0.5564234256744385, -0.16283327341079712, -0.35036593675613403, -0.7261431217193604, 0.31252339482307434, 0.21398428082466125, -0.40772372484207153, 0.3086865544319153, 0.18022935092449188, -0.28257808089256287, -0.000769647303968668, 0.14959055185317993, 0.26711854338645935, -0.5692520141601562, 0.35879650712013245, -0.8844917416572571, -0.015212384052574635, 0.22350043058395386, -0.3865634500980377, -0.1862357258796692, 0.299052894115448, 0.12230319529771805, 0.10024978220462799, -0.23948752880096436, -0.010574866086244583, -0.14628584682941437, -0.08003638684749603, -0.10690315812826157, -0.08335494995117188, 0.6427364349365234, 0.5398115515708923, -0.11629890650510788, 0.07769542932510376, 0.28543999791145325, 0.34398525953292847, 0.7333350777626038, 0.18719586730003357, 0.4770474433898926, 0.6941262483596802, 0.059035807847976685, 0.7254327535629272, 0.07747363299131393, -0.682466447353363, -0.5353022813796997, -0.377502977848053, 0.19403399527072906, -0.7878894209861755, -0.04682428389787674, 0.827451229095459, -0.9325119256973267, 0.24359199404716492, 0.03551677614450455, -0.018386267125606537, -0.5686169266700745, 0.8537452220916748, 0.01224115863442421, -0.5870060920715332, 0.5359501838684082, 1.026401400566101, -0.3482789397239685, -0.02763558179140091, 0.17065103352069855, -0.2660345435142517, 0.3112252354621887, 0.46532633900642395, -0.2847811281681061, 0.4236116409301758, 1.1678967475891113, -1.148712396621704, 0.2475774735212326, 0.4989342987537384, -0.07739211618900299, -0.33398476243019104, -0.5426914095878601, -0.313623309135437, 0.018609192222356796, -0.3299015462398529, 0.20955045521259308, 0.31866782903671265, -0.11392472684383392, -0.08740513771772385, -0.03119582124054432, -0.31520286202430725, 0.23996269702911377, 0.17861297726631165, 0.12133337557315826, 0.0692436546087265, 0.1639230102300644, -0.4181114435195923, -0.28244149684906006, 0.23679327964782715, -0.12167590111494064, 0.4234803318977356, -0.18667304515838623, -0.5621619820594788, -0.08849764615297318, 0.33268001675605774, 0.18408802151679993, -0.30992674827575684, -0.36133867502212524, 0.044887714087963104, -0.33311542868614197, -0.5743468403816223, -0.23622985184192657, -0.18681174516677856, -0.6269395351409912, 0.12813584506511688, -1.075276255607605, -0.33645325899124146, 0.4196963310241699, 0.33326733112335205, -0.03143376484513283, 0.3337347209453583, -0.3476082682609558, 0.1786135733127594, -0.41647276282310486, -0.31154656410217285, 0.0976061150431633, -0.11789177358150482, 0.3400958776473999, 0.20208925008773804, -1.031985878944397, -0.030835596844553947, 0.07321567833423615, 0.7907726168632507, 0.24422042071819305, -0.21564681828022003, -0.46072933077812195, -0.46764835715293884, -0.1464524269104004, -0.24353641271591187, -0.19913305342197418, 0.47162482142448425, -0.16631560027599335, 0.24771295487880707, 0.12644615769386292, 0.10412346571683884, 0.2355438470840454, -0.06826255470514297, -0.7498793005943298, -0.04445698857307434, -0.015234335325658321, -0.5966313481330872, 0.7473863959312439, 0.534483790397644, -0.13106298446655273, 0.20606011152267456, -0.13098295032978058, -0.053453318774700165, 0.09911040216684341, -0.10792157053947449, -0.6057179570198059, 0.43982192873954773, 0.4775294065475464, -0.20561496913433075, 0.2538842558860779, -0.4084107279777527, -0.8245809078216553, -0.6961740255355835, 0.19472728669643402, 0.44380509853363037, -0.6182517409324646, -0.20087110996246338, 0.05265427380800247, -0.7811402082443237, 0.37370631098747253, 0.2943275570869446, -0.9845860004425049, 0.2929093539714813, -0.19935713708400726, 0.37279748916625977, 0.08183800429105759, -0.09650301188230515, -0.15001747012138367, 0.19376599788665771, -0.22137150168418884, -0.07635491341352463, 0.0715678483247757, -0.09884083271026611, 0.3802759051322937, 0.44459474086761475, 0.5230452418327332, -0.4411775767803192, -0.14652644097805023, -0.19219571352005005, -0.04282759502530098, 0.03546975180506706, -0.7787189483642578, -0.753725528717041, 0.5015812516212463, 0.6641813516616821, -0.7725865840911865, 0.1759335696697235, 0.026459312066435814, 1.0504534244537354, -0.34239956736564636, -0.2730178236961365, -0.38475051522254944, -0.8091400861740112, 0.31392911076545715, -0.1037931889295578, -0.7220975160598755, 0.09775102138519287, 0.10295213013887405, 0.5869110822677612, -0.1349378079175949, -0.2540351450443268, -0.4035628139972687, -0.01674838177859783, -0.6903785467147827, 0.12306027114391327, -0.2045886367559433, 0.6553471088409424, -0.2819293439388275, -0.15446652472019196, 0.16327354311943054, 0.09692199528217316, 0.04639146476984024, 0.14062602818012238, 0.6479522585868835, -0.4166419506072998, -0.06466741859912872, 0.3842272162437439, -0.35153424739837646, 0.3717087507247925, -0.8542971014976501, 0.17014674842357635, -0.36099693179130554, -0.22247737646102905, 0.2501845955848694, 0.41134172677993774, -0.12369404733181, -0.719343900680542, -0.09561973810195923, 0.15247058868408203, 0.3049509525299072, 0.12677407264709473, 0.11114951968193054, 0.13949942588806152, -0.4700554609298706, -0.6384498476982117, 0.7656586170196533, 0.5908817648887634, -0.21952731907367706, -0.3040774464607239, 0.3900534212589264, 0.13897022604942322, 0.2065054029226303, -0.6175907254219055, -0.1020931527018547, -0.01922747865319252, 0.053315963596105576, 0.4158661961555481, 0.3634139597415924, -0.2338997721672058, 0.32565388083457947, -0.634300947189331, -0.14395259320735931, 0.04839281737804413, 0.12489104270935059, 0.17846782505512238, 0.8010465502738953, 0.22641706466674805, -0.06271664798259735, 0.3142721354961395, 0.42299801111221313, 0.09783504903316498, -0.06161266192793846, 0.23814275860786438, 0.44310981035232544, 0.7445604205131531, 0.3040100336074829, -0.005100054666399956, 0.865481436252594, 0.31765857338905334, 0.23647409677505493, 0.23160536587238312, -0.6141602396965027, -0.2905100882053375, 0.261618971824646, 0.744888186454773, 0.31255000829696655, -0.34883904457092285, -0.07399266213178635, -0.0955042913556099, 0.3486495018005371, 0.03957363963127136, 0.09192958474159241, -0.07663869112730026, -0.22634628415107727, 0.011325390078127384, -0.5871284008026123, -0.7462142109870911, 0.2206515222787857, -0.6446590423583984, 0.48863089084625244, 0.39563214778900146, -0.20324793457984924, -0.057611383497714996, 0.1537920981645584, -0.35278892517089844, 0.07293318957090378, -0.08111366629600525, 0.3836374878883362, 0.0942821055650711, -0.29084479808807373, 0.44614550471305847, -0.12249722331762314, 0.28490662574768066, -0.2618093490600586, 0.4420122504234314, 0.23489445447921753, -0.43538540601730347, -0.1279842108488083, 0.22574979066848755, 0.10492448508739471, 0.18320471048355103, 0.09121602028608322, 0.0361001081764698, 0.41405704617500305, -0.7416769862174988, -0.16014020144939423, 0.12719295918941498, -0.41270312666893005, -0.29357919096946716, -0.4759458303451538, -0.22540882229804993, 0.1325467973947525, 0.23467130959033966, 0.1609477400779724, -0.036901578307151794, -0.480984091758728, 0.7402365207672119, 0.4017517864704132, -0.0804448127746582, 0.13622038066387177, -0.01616043969988823, 0.2924331724643707, 0.37490373849868774, 0.6829363703727722, -0.33999916911125183, -0.16525162756443024, -0.17075957357883453, 0.565624475479126, -0.5690211057662964, 0.4036782681941986, -0.5345215201377869, -0.4852852523326874, -0.2980211079120636, -0.11724931001663208, 1.1570885181427002, 0.6754852533340454, -0.21096722781658173, 0.29993173480033875, 0.2274419665336609, 0.6497015953063965, 0.5219857692718506, -0.2146420180797577, -0.2991139888763428, -0.5246655941009521, -0.26240822672843933, -0.6305474638938904, 0.30375340580940247, 0.1096424013376236, -0.06311865895986557, 0.23151904344558716, 0.49095502495765686, 0.5252739787101746, -0.3840840458869934, 0.28530529141426086, -0.3144208490848541, 0.200494647026062, -0.6413962244987488, 0.7159734964370728, -0.5430428385734558, 0.3938888907432556, -0.3393806219100952, -0.2413455694913864, 0.14534467458724976, -0.07091295719146729, 0.017918618395924568, -0.4998124837875366, -0.16570891439914703, 0.25663188099861145, 0.2766832113265991, 0.22402386367321014, -0.0909837856888771, -0.5443370342254639, -0.8066883087158203, 0.18986210227012634, -0.34789755940437317, -0.5958583950996399, 0.43870285153388977, -0.025648964568972588, -0.20431950688362122, 0.16042116284370422, -0.043396029621362686, -0.530734658241272, -0.18196968734264374, 0.11195562779903412 ]
Two separate in vitro assays were used to examine the biosynthesis of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid (KYNA) during the life span of the adult rat. Assessment of KYNA's anabolic enzyme kynurenine aminotransferase revealed steady increases between 3 and 24 months of age in all five brain regions examined. No changes were observed in the liver. The changes were particularly pronounced in the cortex and in the striatum where enzyme activity increased three-fold during the period studied. KYNA production from its bioprecursor L-kynurenine was also investigated in tissue slices and was found to be significantly enhanced in the cortex and hippocampus of old animals. The effect of depolarizing agents or sodium replacement was virtually identical in tissues from young and old rats. These data, which are in excellent agreement with reports on an age-dependent increase of KYNA concentration in brain tissue, suggest an enhanced KYNA tone in the aged brain. Together with the reported decline in cerebral excitatory amino acid receptor densities with age, increased production of KYNA may play a role in cognitive and memory dysfunction in old animals.
[ -0.006075387354940176, 0.0060169692151248455, -0.014866466633975506, 0.021331071853637695, -0.005574345588684082, -0.0030959085561335087, 0.010445447638630867, -0.0033609645906835794, -0.011390523053705692, -0.012058325111865997, -0.012373914942145348, 0.012174470350146294, -0.021481288596987724, 0.01254216581583023, -0.002629766473546624, 0.011959720402956009, -0.015208879485726357, 0.026930175721645355, 0.008612997829914093, -0.019208498299121857, -0.0278475284576416, -0.011679666116833687, 0.008507786318659782, -0.014753025956451893, 0.01865670457482338, -0.0002762099029496312, 0.006968704517930746, 0.001738180872052908, 0.026905246078968048, -0.020494326949119568, 0.0030111800879240036, -0.0018244050443172455, -0.009844927117228508, 0.0021094733383506536, 0.00020482600666582584, 0.00305405305698514, -0.0015366714214906096, 0.020243454724550247, 0.04657597094774246, -0.0040726326406002045, -0.004295182414352894, -0.009293317794799805, 0.009537724778056145, 0.006117296405136585, -0.006791946943849325, -0.0287026334553957, -0.008847376331686974, 0.022171251475811005, 0.006221149116754532, 0.006253575906157494, -0.008288431912660599, -0.026678871363401413, -0.0227992944419384, 0.015540551394224167, -0.005462945438921452, -0.010820271447300911, 0.015731515362858772, -0.016140330582857132, -0.00817212462425232, -0.024629682302474976, -0.013352258130908012, -0.011224993504583836, 0.02310766838490963, -0.02593192085623741, 0.0017288050148636103, -0.06687456369400024, 0.015199298039078712, -0.0026178620755672455, -0.01006849855184555, 0.01747060939669609, -0.002102225087583065, 0.007607509382069111, 0.001782810315489769, -0.041539084166288376, -0.010469724424183369, 0.013599440455436707, -0.009383811615407467, -0.01110532321035862, 0.021961722522974014, -0.002429051324725151, -0.022593503817915916, 0.0036184696946293116, 0.02247248776257038, 0.007414305116981268, -0.025746360421180725, -0.0035324464552104473, -0.015339103527367115, 0.003728920128196478, 0.03049515187740326, -0.031242037191987038, -0.003757268190383911, 0.002366378204897046, 0.004642185755074024, -0.004161474294960499, -0.00018003396689891815, 0.0018905175384134054, 0.013415727764368057, 0.006115919444710016, 0.033573053777217865, -0.022041406482458115, -0.017009293660521507, 0.005571951158344746, 0.021548092365264893, 0.021813537925481796, 0.002521912567317486, 0.004768382757902145, -0.006984665524214506, 0.03560132160782814, 0.02413090504705906, 0.008091406896710396, -0.0038020294159650803, 0.008895834907889366, 0.026775186881422997, 0.011448018252849579, 0.022788608446717262, 0.001826641382649541, -0.022956080734729767, 0.004129036329686642, 0.0012131944531574845, -0.027704570442438126, 0.030596280470490456, 0.006086545996367931, -0.01231824979186058, -0.013102575205266476, -0.001901094801723957, -0.004426874686032534, 0.0033856360241770744, -0.006403702776879072, -0.008662723004817963, 0.0004659048281610012, -0.004303383640944958, 0.014391867443919182, -0.018363850191235542, -0.011301524005830288, -0.0036789271980524063, -0.0076972185634076595, -0.021896008402109146, -0.015941910445690155, -0.015775363892316818, 0.010473246686160564, 0.005787518806755543, 0.00599236274138093, 0.00616073701530695, 0.004095034673810005, 0.018219754099845886, 0.004198706708848476, 0.004191222600638866, 0.001792925875633955, 0.023085031658411026, -0.0311572328209877, -0.0068476637825369835, 0.005291296634823084, 0.006507642567157745, -0.015268850140273571, 0.016299253329634666, 0.015813443809747696, -0.012604478746652603, -0.050213687121868134, 0.00895526260137558, -0.00587701890617609, 0.002879481762647629, -0.00887945294380188, 0.01497985515743494, 0.008922511711716652, -0.018376989290118217, -0.02651233598589897, -0.011341601610183716, 0.0012567657977342606, -0.02226223051548004, 0.008622342720627785, -0.009098188951611519, -0.007678226567804813, -0.010835887864232063, 0.0034580593928694725, -0.021745428442955017, -0.010978387668728828, 0.014389825984835625, 0.006215331144630909, -0.012882137671113014, 0.06647875905036926, -0.015742836520075798, 0.03571658208966255, -0.0022763495799154043, 0.016368087381124496, 0.0014020628295838833, -0.012057257816195488, 0.021234437823295593, -0.003593951230868697, 0.014360633678734303, 0.030407145619392395, 0.020106438547372818, -0.0032628634944558144, 0.013391980901360512, 0.0053656334057450294, 0.005655624438077211, 0.0019033367279917002, 0.022829025983810425, 0.009193364530801773, -0.02337624318897724, 0.017306433990597725, -0.02534378506243229, -0.0012331274338066578, 0.00692347064614296, 0.002514209831133485, 0.018623171374201775, -0.0034072648268193007, 0.02045830711722374, -0.01892116293311119, 0.008665882050991058, -0.01768467389047146, 0.010142549872398376, -0.020181290805339813, -0.009281856007874012, -0.010991834104061127, 0.0035619717091321945, 0.017171241343021393, 0.005884847138077021, 0.009380761533975601, -0.000351125025190413, -0.01051366701722145, 0.004684895277023315, -0.00030729779973626137, -0.011951962485909462, 0.004081276711076498, 0.006046620663255453, -0.00755863543599844, 0.009343355894088745, 0.008424937725067139, -0.03474263846874237, 0.009837348014116287, -0.007417032960802317, -0.021846823394298553, -0.011272517964243889, 0.026004891842603683, 0.000019281869754195213, -0.005492141004651785, 0.012864550575613976, -0.010492837056517601, 0.01654728315770626, -0.004886713810265064, 0.013423396274447441, 0.011271758005023003, -0.0008372464217245579, -0.004919074010103941, 0.0048494404181838036, -0.03540153056383133, -0.01219323743134737, -0.0011027324944734573, 0.020899556577205658, -0.034372828900814056, 0.007183384615927935, -0.017648248001933098, -0.04093080759048462, -0.004648543428629637, -0.028811300173401833, -0.022710707038640976, -0.030934428796172142, -0.024108942598104477, 0.02487969771027565, 0.0031892373226583004, 0.0057365139946341515, 0.009177422150969505, 0.005673413164913654, -0.020265404134988785, -0.012277321889996529, -0.015550827607512474, 0.004210900515317917, 0.029980914667248726, -0.02000483125448227, 0.014318534173071384, 0.008681554347276688, -0.005861448124051094, -0.0021303589455783367, -0.08199668675661087, -0.0018993488047271967, -0.018650081008672714, 0.0002917279489338398, 0.00024547582142986357, 0.048198118805885315, 0.00822455808520317, -0.004543496295809746, -0.002162262797355652, -0.0003290784079581499, -0.00750935822725296, -0.006750405300408602, 0.0025993166491389275, -0.006038583815097809, 0.03163594752550125, -0.0005331758875399828, 0.008522565476596355, -0.0015639029443264008, -0.007239294238388538, -0.03227698802947998, 0.00876760296523571, 0.005471761338412762, -0.017169255763292313, 0.0020908790174871683, 0.015329543501138687, 0.0018698712810873985, 0.012354526668787003, -0.023146875202655792, 0.005108787678182125, 0.026278547942638397, -0.02360570803284645, -0.004230887163430452, -0.03326454758644104, 0.018372707068920135, 0.02548539638519287, 0.008950645104050636, -0.024794157594442368, 0.018516534939408302, -0.013716657646000385, 0.055690910667181015, -0.02878396585583687, 0.00807613879442215, 0.01156777236610651, -0.023279473185539246, 0.005468650721013546, -0.005999905057251453, 0.03027161955833435, 0.010439972393214703, 0.009371122345328331, -0.004681429825723171, 0.038875214755535126, 0.0020424698013812304, 0.018741779029369354, 0.010772783309221268, -0.015206392854452133, -0.006413325667381287, 0.0201330054551363, 0.01932460442185402, -0.0070190392434597015, -0.01220656093209982, -0.034984223544597626, -0.004759823903441429, 0.013226511888206005, 0.03758053481578827, 0.04878465086221695, 0.003151599783450365, 0.011294697411358356, 0.0026580113917589188, -0.008470832370221615, 0.026041792705655098, 0.0019929888658225536, -0.0022614095360040665, -0.016840748488903046, -0.008920205757021904, -0.016232764348387718, -0.010727881453931332, -0.01734580658376217, 0.003279897617176175, 0.012034238316118717, -0.00426753843203187, 0.014822970144450665, 0.0018400211120024323, -0.009430905804038048, -0.0021953112445771694, 0.00022550555877387524, -0.033354587852954865, 0.007554288022220135, 0.04485916346311569, 0.02184436097741127, -0.009936336427927017, 0.03431694582104683, 0.0069360071793198586, 0.017240937799215317, 0.011903190985321999, 0.01947662979364395, -0.019049929454922676, -0.019198570400476456, -0.011154407635331154, 0.009217817336320877, 0.006250021513551474, -0.015488337725400925, -0.016854066401720047, 0.02522365376353264, -0.004839414265006781, -0.002128022722899914, 0.010548565536737442, -0.00783906877040863, 0.021208351477980614, -0.011967573314905167, 0.005017789080739021, -0.008216657675802708, -0.011307993903756142, -0.0025911652483046055, 0.0314161479473114, 0.005536099895834923, -0.00131207425147295, -0.004341069143265486, -0.001572172623127699, 0.07278954982757568, 0.01468781940639019, 0.009238019585609436, -0.01923413947224617, 0.011838696897029877, -0.004997672513127327, 0.019202500581741333, -0.0028826138004660606, -0.012318329885601997, -0.005801953375339508, 0.012070838361978531, -0.0006345119327306747, -0.008204616606235504, -0.009086987003684044, -0.02191191539168358, -0.009779881685972214, -0.015823937952518463, -0.007588776294142008, 0.0026830611750483513, 0.004450807347893715, 0.00567514356225729, -0.009554054588079453, 0.004581707529723644, -0.02382040210068226, 0.002539967419579625, -0.018169037997722626, 0.005980614572763443, -0.010306832380592823, -0.01841452717781067, 0.013718598522245884, 0.0043075839057564735, 0.010155608877539635, -0.009640201926231384, -0.0024140041787177324, -0.0014397348277270794, 0.00005998299457132816, 0.009994576685130596, -0.00938735157251358, 0.017360122874379158, -0.004824473522603512, -0.0049394965171813965, -0.009192751720547676, -0.001022711512632668, 0.0023169780615717173, 0.00047524599358439445, -0.009790202602744102, -0.007409094367176294, -0.005500543862581253, 0.005357131361961365, 0.002725533675402403, -0.005586580839008093, 0.004458311013877392, 0.00977267511188984, -0.0059101395308971405, 0.0021142771001905203, 0.00692975427955389, 0.02706126496195793, -0.02570171281695366, -0.03728986158967018, -0.01883990876376629, -0.013239916414022446, -0.003544720821082592, 0.010908948257565498, -0.01663273200392723, -0.010561641305685043, -0.016730288043618202, 0.006044173613190651, 0.009074417874217033, 0.009022088721394539, 0.025932002812623978, 0.006861989852041006, -0.007381081581115723, 0.00024203001521527767, -0.0070296283811330795, 0.007003164850175381, -0.012538637965917587, -0.01212482713162899, 0.019698873162269592, 0.007064618170261383, -0.0099458247423172, 0.008173951879143715, 0.030936460942029953, 0.031719036400318146, 0.006981375627219677, 0.028774842619895935, 0.015449916943907738, -0.010170802474021912, -0.0753045454621315, -0.012777982279658318, 0.012911869212985039, -0.009937789291143417, 0.011348041705787182, 0.01666543073952198, -0.034396134316921234, -0.0051034376956522465, 0.012364554218947887, 0.0065511176362633705, 0.0200833510607481, 0.010166171938180923, 0.011942123994231224, -0.013180181384086609, 0.011856090277433395, -0.00807466171681881, -0.02121875248849392, -0.006164065096527338, -0.003133779391646385, 0.009006367065012455, 0.004421766381710768, 0.0204622820019722, 0.016962803900241852, 0.014633100479841232, -0.0019022312480956316, -0.0815080851316452, -0.014831198379397392, -0.003226182423532009, 0.01132307481020689, 0.011272837407886982, 0.04220425710082054, 0.018969986587762833, -0.012884377501904964, 0.014288177713751793, -0.014685113914310932, 0.01106618344783783, 0.0056058866903185844, -0.025096651166677475, -0.006300664972513914, -0.002469098661094904, -0.008146334439516068, 0.0017486819997429848, 0.018567830324172974, 0.02795596793293953, 0.005578289739787579, -0.012001424096524715, 0.03458259999752045, -0.007634524255990982, 0.011371280066668987, -0.0022589839063584805, -0.0073353443294763565, -0.00009939516894519329, 0.015937665477395058, 0.007516050711274147, -0.01648886501789093, -0.006309888791292906, -0.018890101462602615, -0.012099669314920902, -0.004595011938363314, -0.02011715993285179, -0.01161724142730236, -0.015715785324573517, -0.030294787138700485, -0.012450662441551685, -0.00474749319255352, -0.004760305397212505, -0.003618965856730938, 0.0066277156583964825, -0.004635087680071592, -0.01136171817779541, -0.0013183869887143373, 0.006700824946165085, -0.010196283459663391, -0.00599421001970768, -0.0038452940061688423, 0.010820472612977028, 0.006990524474531412, 0.005861315876245499, 0.021065954118967056, -0.003376806154847145, -0.01414712704718113, -0.002506427001208067, 0.008972926065325737, 0.011726191267371178, 0.007008819375187159, -0.0066176000982522964, -0.005531210917979479, 0.01964704506099224, 0.07151921093463898, 0.011564359068870544, -0.0034249371383339167, -0.033547043800354004, 0.0004895313177257776, 0.0065178340300917625, 0.02409205585718155, 0.008873596787452698, -0.013485086150467396, -0.013181131333112717, -0.01743168942630291, -0.0026988498866558075, -0.02420426532626152, 0.011378291994333267, -0.006699336692690849, 0.007880665361881256, -0.022735489532351494, 0.02264292910695076, -0.02935735508799553, 0.023080043494701385, -0.0026406061369925737, 0.013493796810507774, -0.02679010108113289, -0.013121919706463814, -0.027665086090564728, -0.011866853572428226, 0.008781066164374352, 0.004110796842724085, -0.006836886517703533, -0.0006485157646238804, -0.006856516469269991, -0.0027773655019700527, 0.003056666348129511, 0.0019666198641061783, 0.003761397674679756, 0.005009374115616083, 0.003800155594944954, 0.012545488774776459, -0.014157760888338089, -0.038966018706560135, -0.001139544416218996, -0.01750275120139122, 0.008433302864432335, -0.0020306615624576807, 0.015468554571270943, -0.013190893456339836, 0.005778287071734667, 0.00912109948694706, -0.004362897947430611, 0.011067722924053669, 0.034306082874536514, 0.007976703345775604, -0.019175246357917786, -0.020254574716091156, 0.0033526234328746796, -0.0006289363373070955, -0.021881766617298126, 0.012035016901791096, -0.01603798195719719, -0.021143190562725067, 0.01752270571887493, -0.004771491978317499, 0.0009020944125950336, -0.02879220061004162, 0.011264769360423088, -0.011725211516022682, 0.022239472717046738, -0.006801968906074762, 0.006671834737062454, 0.010595869272947311, -0.003101081121712923, -0.010886089876294136, 0.006955868564546108, 0.020922163501381874, 0.03430326282978058, 0.0011697504669427872, 0.006686806678771973, -0.0068485066294670105, 0.03195662796497345, -0.00011099502444267273, -0.022543810307979584, 0.007050173822790384, -0.0012953742407262325, 0.002228502184152603, -0.009120326489210129, 0.005518039688467979, 0.012361442670226097, -0.013046715408563614, 0.002419627271592617, -0.00039193546399474144, -0.0035406718961894512, -0.0015506655909121037, 0.004195325542241335, 0.0060311551205813885, 0.007340678013861179, 0.034237977117300034, 0.013287311419844627, 0.0013727762270718813, -0.011477148160338402, -0.0062915063463151455, -0.03183302283287048, 0.005487919319421053, -0.01899845153093338, -0.03028446063399315, 0.003571644891053438, -0.001978865824639797, 0.004740368574857712, -0.01518842950463295, 0.04172184690833092, 0.01998453587293625, 0.008363869041204453, -0.005435439758002758, 0.016926318407058716, 0.0013174689374864101, -0.006473922170698643, 0.015521641820669174, -0.017060134559869766, -0.0087587246671319, -0.021394915878772736, -0.015123805031180382, -0.0074080126360058784, -0.015765756368637085, -0.001404724083840847, -0.0018884259043261409, 0.012044566683471203, -0.022293157875537872, -0.010165657848119736, -0.0014322192873805761, 0.02840700000524521, -0.01180102489888668, 0.01886875554919243, -0.004072863608598709, -0.0007985089905560017, -0.00818227231502533, -0.011356344446539879, -0.015045713633298874, -0.010700374841690063, 0.015471108257770538, -0.017979295924305916, 0.010422511026263237, 0.019274016842246056, 0.0038545187562704086, 0.005125559866428375, 0.020142465829849243, 0.008052052929997444, -0.014534037560224533, 0.01275142002850771, 0.01163463108241558, 0.010521757416427135, -0.008475934155285358, -0.000297811406198889, 0.0098051056265831, 0.0012160567566752434, -0.00938879232853651, -0.030391717329621315, 0.011644326150417328, 0.010230932384729385, -0.023157086223363876, 0.018931351602077484, -0.009583638980984688, -0.007572825066745281, -0.0015753554180264473, 0.012459296733140945, -0.008504337631165981, 0.007485229056328535, -0.023933205753564835, 0.01395468506962061, 0.0004936903715133667, 0.02174326591193676, 0.021692238748073578, 0.002791660837829113, 0.0020851597655564547, 0.01233404129743576, 0.03439310938119888, -0.004871568642556667, -0.008929172530770302, -0.03120821714401245, 0.0005133498925715685, 0.04489342123270035, -0.00017251656390726566, 0.0055988384410738945, -0.019549764692783356, 0.002954640192911029, -0.007864365354180336, 0.011853529140353203, -0.03290187567472458, -0.001720526022836566, 0.015156809240579605, 0.009542809799313545, 0.03147309646010399, -0.04232420772314072, 0.010401222854852676, -0.003872484667226672, 0.02246158756315708, -0.02191098965704441, 0.0016743829473853111, 0.006186880171298981, 0.013074303045868874, 0.006738821975886822, 0.01287497766315937, 0.00693090446293354, -0.008555709384381771 ]
[ -0.26573842763900757, -0.12050575017929077, -0.031774625182151794, -0.1904786229133606, -0.15530799329280853, 0.3935825526714325, 0.18185009062290192, -0.3131297826766968, -0.042633164674043655, -0.44584977626800537, -0.061753273010253906, 0.38612663745880127, -0.35204246640205383, 0.17370381951332092, 0.22994975745677948, 0.9129884243011475, 0.6801887154579163, 0.29536357522010803, -0.1742989867925644, -0.643689751625061, -0.06796945631504059, -0.18609581887722015, 0.7172290682792664, -0.2379692643880844, -0.024715173989534378, -0.048572782427072525, 0.4174305200576782, -0.25126227736473083, 0.4356801509857178, -0.019762888550758362, -0.5953208208084106, 0.6190364360809326, -0.19135677814483643, -0.3636499345302582, 0.004059586673974991, 0.6192972660064697, -0.449849933385849, -0.0443836972117424, 0.13102532923221588, -0.3173447251319885, -0.47350722551345825, -0.1087794154882431, -0.560931384563446, 0.39638659358024597, -0.5523566007614136, 0.32728010416030884, -1.315805435180664, 0.39525336027145386, -0.038434989750385284, -0.11395005881786346, 0.0007031530258245766, -0.07221396267414093, 0.725395143032074, -0.3895193338394165, 0.20683810114860535, -0.12889784574508667, -0.6349597573280334, 0.0077777742408216, 0.2688763737678528, -0.19302330911159515, 0.5932785272598267, -0.014124187640845776, 0.017280325293540955, 0.2591628134250641, -0.5415926575660706, 0.29567471146583557, 0.10251091420650482, -0.11996657401323318, -0.7763356566429138, 0.2924259901046753, 0.09875685721635818, 0.13687321543693542, -0.38392701745033264, 0.6672467589378357, -0.2526038587093353, -0.12144258618354797, -0.03367359936237335, -0.1521623134613037, 0.370148241519928, 0.08517329394817352, 0.4289132058620453, 0.15403127670288086, 0.5746006369590759, 0.3224911093711853, -0.05673528090119362, 0.35836538672447205, -0.10506705194711685, 0.6765584945678711, -0.7279790639877319, -0.18828092515468597, -0.3709799647331238, -0.2255936712026596, 0.7441735863685608, 0.5225858092308044, -0.26328110694885254, 0.2827581763267517, 0.17385846376419067, -0.39750006794929504, -0.06537912040948868, -0.0745057687163353, 0.1975688338279724, 0.03820232301950455, -0.483914852142334, -0.3928091526031494, -0.316171258687973, -0.3462517261505127, -0.33427149057388306, -1.12788724899292, -0.3592067360877991, 0.1572500318288803, -0.8825933933258057, 0.33441242575645447, -0.28265058994293213, -0.26371514797210693, -0.2832109034061432, -0.31645411252975464, 0.016520267352461815, 0.13078905642032623, -0.08601558953523636, 0.10615422576665878, -0.4726463258266449, 0.49541807174682617, -0.2003808170557022, 0.31942710280418396, -0.15106911957263947, 0.04331723600625992, 0.3219422996044159, -0.3109733462333679, 0.11540934443473816, 0.2046135812997818, 0.36950504779815674, 0.19109775125980377, -0.10660287737846375, 0.0010214089415967464, -0.05996635556221008, -0.04579108953475952, 0.3575102686882019, 0.046633921563625336, 0.26612505316734314, 0.4102511703968048, -0.0645827054977417, -0.1903386265039444, -0.6285905838012695, -0.12620945274829865, 0.21395795047283173, -0.44254565238952637, 0.1786927431821823, 0.5787091255187988, -0.11001459509134293, -0.022058993577957153, 0.45522093772888184, -0.158255472779274, -0.29699796438217163, 0.016438717022538185, 0.007305331528186798, 0.11091405153274536, -1.1508283615112305, -0.16395242512226105, 0.2593938708305359, -0.029702303931117058, 0.27886196970939636, 0.042697131633758545, -0.35082992911338806, -0.4099566340446472, 0.5162519812583923, -0.019274648278951645, 0.29579052329063416, 0.6284619569778442, 0.009920692071318626, -0.15989559888839722, -0.28199437260627747, -0.3107685446739197, 0.41895753145217896, -0.43102332949638367, -0.7230395674705505, 0.01056125108152628, 0.020046651363372803, 0.025237198919057846, 0.09086018055677414, -0.3767305910587311, -0.8597357273101807, -0.2843528091907501, 0.01590730808675289, 0.005996559280902147, 0.30612874031066895, 0.14804978668689728, 0.4878021776676178, -0.12141401320695877, 0.14756335318088531, 0.3199198842048645, 0.25779080390930176, -0.18360070884227753, 0.696333110332489, -0.29985466599464417, 1.2236384153366089, -0.1196892037987709, -0.24269963800907135, 0.785442590713501, 0.37597769498825073, 0.2090405821800232, -0.17610470950603485, -0.2742663621902466, 0.491644948720932, -0.4107912480831146, -0.4003973603248596, -0.07754215598106384, -0.4046836197376251, -0.4857180416584015, 0.13119642436504364, 0.18389692902565002, 0.14004386961460114, -0.5752431154251099, 0.14675219357013702, 0.3211353123188019, 0.36916765570640564, -0.38819292187690735, 0.13292133808135986, 0.05035749822854996, -0.12184321135282516, 0.2850114703178406, -0.16770817339420319, -0.4414120614528656, 0.28025034070014954, 0.4162125885486603, -0.04401128366589546, 0.2858447730541229, 0.5901528596878052, 0.23970268666744232, 0.5685132741928101, -0.4270547926425934, 0.3448529541492462, -0.3408960998058319, 0.10549311339855194, -0.15212008357048035, 0.3046362102031708, -0.07196564227342606, -0.1389361023902893, -0.29139405488967896, -0.08680746704339981, -0.33123883605003357, -0.19131937623023987, 0.2994184195995331, -0.1432134211063385, -0.06967959553003311, 0.280916690826416, -0.19804681837558746, 0.15007993578910828, 0.7934490442276001, -1.039036750793457, -0.08687742054462433, -0.19479091465473175, 0.34022068977355957, 0.416841059923172, -0.2964945137500763, -0.02881738170981407, -0.1886201947927475, -0.1829889565706253, -0.26733580231666565, -0.18875841796398163, -0.4723148047924042, -0.17534294724464417, 0.2383347898721695, 0.4065118730068207, 0.1005135104060173, 0.007035445421934128, -0.8184933662414551, -1.1254825592041016, -0.40012499690055847, 0.8010538816452026, 0.3067184388637543, 1.130620002746582, -0.13608776032924652, -0.3349469006061554, -0.3525463044643402, -0.2854883670806885, -0.540190577507019, 0.12331052124500275, 0.33105990290641785, -0.7740970253944397, -0.5748459696769714, 0.15500546991825104, 0.7114162445068359, 0.5499863028526306, 0.06893938779830933, -0.34730398654937744, 0.09019361436367035, -0.1144770011305809, -0.7700920701026917, 0.0314691998064518, -0.34502169489860535, 0.33222270011901855, 0.3208964467048645, -0.2974798381328583, -0.052913036197423935, 0.20961277186870575, 0.21706661581993103, 0.07330821454524994, 0.7242028713226318, 0.6374620199203491, -0.14659211039543152, -0.13477467000484467, 0.17614704370498657, -0.1551048904657364, 0.2363486886024475, 0.25066572427749634, 0.10786916315555573, -0.13592176139354706, 0.013204507529735565, -5.850586414337158, 0.22113868594169617, -0.38577091693878174, -0.4411335289478302, 0.4802972972393036, 0.2547152042388916, 0.7668165564537048, 0.0869813784956932, -0.3349968194961548, 0.5667847394943237, -0.23658303916454315, 0.22896626591682434, -0.2560740113258362, 0.059430286288261414, -0.6921411752700806, -0.30036845803260803, -0.04419431462883949, -0.228200301527977, 0.06496640294790268, -0.012654903344810009, 0.22131706774234772, -0.8335205912590027, -0.37449759244918823, 0.6743691563606262, -0.1535884439945221, -0.15651251375675201, -0.44611456990242004, -0.19235242903232574, -0.6563330292701721, -0.6027445793151855, -0.24463292956352234, -0.26327773928642273, -0.343334436416626, 0.06464578956365585, 0.5518632531166077, -0.05242956057190895, -0.1730264574289322, 0.1452631652355194, 0.0026932801119983196, -0.8199910521507263, 0.26675382256507874, 0.03789089247584343, 0.24067531526088715, -0.16548854112625122, 0.45197999477386475, 0.2616884410381317, -0.17569103837013245, 0.0006762570701539516, -0.4185771346092224, 0.2650761604309082, -0.2622724175453186, -0.08809393644332886, -0.06743159890174866, 0.6539900302886963, 0.35750943422317505, 0.2096361666917801, -0.2367735356092453, -0.04686001315712929, -0.043704044073820114, 0.30533304810523987, -0.10205492377281189, 0.10153426229953766, -0.6744775772094727, -0.6184519529342651, -0.2251814305782318, -0.007510981522500515, -0.5812054872512817, -0.37048691511154175, 0.12334620207548141, 0.14927475154399872, -0.3773269057273865, 0.011829886585474014, 0.10415346175432205, -0.9093300700187683, 0.5133295655250549, -0.25128665566444397, 0.2966332733631134, 0.5165864825248718, -0.3417942225933075, 0.42294207215309143, -0.31399738788604736, -0.35271385312080383, 0.36462074518203735, 0.31562551856040955, -0.04994406923651695, -0.2665642499923706, -0.15464651584625244, 0.1964898258447647, 0.2559369206428528, 0.38256731629371643, 0.6333892345428467, -0.07134298235177994, -0.10345558077096939, 0.38666969537734985, -0.03065326064825058, -0.1771649420261383, -0.03625316545367241, 0.7089866399765015, 0.5697831511497498, 0.4980725049972534, 0.703698456287384, -0.03998277708888054, -0.3141138255596161, -0.2798865735530853, -0.07528583705425262, 0.49766138195991516, -0.6474359035491943, -0.1655583530664444, 0.8203912973403931, -0.8392027020454407, -0.27253270149230957, -0.1131717786192894, -0.28818902373313904, 0.46452537178993225, 0.7062328457832336, -0.27483442425727844, 0.03407754376530647, 0.06371967494487762, 0.23922030627727509, -0.14781251549720764, -0.19633789360523224, 0.26285332441329956, -1.0353015661239624, 0.2553272843360901, 0.06786005198955536, -0.423880010843277, 0.09931933134794235, 0.5256999731063843, -0.6266850233078003, 0.05556369572877884, 0.15838415920734406, 0.33559244871139526, -0.3735309839248657, -0.08465179800987244, -0.17534837126731873, -0.8155224323272705, -0.21325847506523132, 0.3838833272457123, 0.379626989364624, 0.006961681414395571, 0.1486901342868805, -0.40191423892974854, 0.2454831302165985, -0.2850828766822815, 0.07657608389854431, -0.024823512881994247, 0.45075535774230957, -0.18376395106315613, -0.7762887477874756, -0.2623562514781952, 0.3181060254573822, -0.6132882833480835, -0.11437299102544785, 0.3800741136074066, -0.23521459102630615, 0.22874103486537933, 0.3530091941356659, 0.3073423206806183, 0.2865845561027527, -0.2978460490703583, -0.1445903778076172, -0.10975377261638641, -1.0866100788116455, -0.2588310241699219, -0.13650459051132202, -0.2542710602283478, 0.1405184417963028, -0.2624635100364685, 0.215126633644104, 0.025752751156687737, -0.11379130184650421, -0.47359704971313477, -0.019741768017411232, -0.29755085706710815, 0.11941733211278915, -0.024489330127835274, -0.19662979245185852, -0.2615019381046295, -0.42940980195999146, 0.2603784203529358, -0.09576812386512756, -0.12438207864761353, -0.4051222503185272, -0.22902315855026245, 0.5109740495681763, -0.0012867882614955306, -0.22387102246284485, -0.0899859368801117, -0.0021605289075523615, -0.6253421306610107, 0.30789026618003845, 0.08369793742895126, -0.31352460384368896, -0.39325979351997375, 0.37008506059646606, 0.05212841182947159, 0.44260671734809875, 0.8604314923286438, -0.07845569401979446, -0.22251258790493011, 0.27766022086143494, 0.11937001347541809, 0.30856359004974365, 0.32163459062576294, 0.9401682615280151, -0.20057173073291779, -0.45223045349121094, 0.44464460015296936, -0.5018751621246338, -0.2852790057659149, -0.1518961638212204, -0.9099330902099609, -0.34929734468460083, -0.33166369795799255, -0.09775247424840927, 0.14231102168560028, 0.18802198767662048, -0.6344946622848511, -0.5417075157165527, 0.35490286350250244, 0.15132494270801544, 0.033954136073589325, -0.004969376605004072, -0.2911562919616699, -0.5652375817298889, -0.5001289248466492, 0.4598214626312256, -0.777187168598175, 0.44737619161605835, -0.09411944448947906, 0.17560184001922607, 0.10308979451656342, 0.03917274996638298, 0.09572212398052216, -0.15455815196037292, -0.8291313052177429, -0.2062196135520935, 0.2537410259246826, -0.3644438683986664, 0.4320504665374756, -0.036434806883335114, 0.6799364686012268, 0.07967013865709305, 0.6201479434967041, -0.22769887745380402, 0.16297824680805206, 0.04139496013522148, -0.127770334482193, 0.12945029139518738, 0.11655104160308838, 0.09025257080793381, 0.3149554133415222, 0.4924679398536682, 0.286977082490921, 0.8664820790290833, -0.20423495769500732, 0.25417560338974, -0.3432748019695282, -0.16886617243289948, 0.3194100260734558, -0.07117311656475067, 0.136384978890419, -0.2825130224227905, 0.47516873478889465, -0.07486242800951004, 0.2730873227119446, -0.20080524682998657, -0.8891139030456543, 1.0637494325637817, -0.43312281370162964, 0.22909483313560486, 0.14775466918945312, 0.45877477526664734, 0.4191392958164215, 0.1726752668619156, 0.20443081855773926, 0.2928532063961029, 0.2849369943141937, 0.253917932510376, 0.028087805956602097, 0.09814861416816711, -0.14754365384578705, 0.2859272360801697, -0.5685120224952698, 0.28841832280158997, -0.7873624563217163, 0.05210014805197716, -0.8060787320137024, -0.2241269052028656, -0.15159153938293457, -0.0724899172782898, 0.6120362281799316, -0.5447829365730286, -0.16801828145980835, -0.42442044615745544, 0.6750138998031616, 0.16301187872886658, 0.275945782661438, 0.1146470382809639, -0.3019299805164337, -0.23194630444049835, 0.2635810971260071, 0.8959470391273499, 0.11697102338075638, -0.5438183546066284, 0.38767191767692566, 0.5083132386207581, 0.06307163834571838, -0.6858482956886292, 0.24727360904216766, 0.21945059299468994, 0.0783076137304306, 0.7800413966178894, 0.2827824354171753, -0.4567036032676697, 0.11351237446069717, 0.1418488621711731, 0.39204901456832886, 0.0927293598651886, 0.15812671184539795, 0.24757277965545654, 0.6675463914871216, 0.43266400694847107, 0.16203221678733826, -0.1506921797990799, 0.26409706473350525, 0.29268792271614075, 0.25739791989326477, 0.2927420139312744, 0.9146916270256042, 0.32832762598991394, 0.47512713074684143, 0.17048566043376923, 1.1948919296264648, 0.5511800646781921, -0.082511767745018, 0.1813453584909439, -0.12008629739284515, -0.4526543915271759, 0.11568408459424973, 1.0634557008743286, 0.1172722578048706, -0.04045208543539047, -0.10229833424091339, 0.3248264491558075, 0.12226095795631409, 0.12494037300348282, -0.04227543622255325, -0.3059523105621338, 0.23418764770030975, 0.567150354385376, 0.04972192645072937, -0.4168010354042053, 0.45375680923461914, -0.5994592905044556, 0.24948321282863617, 0.5911330580711365, -0.5065076351165771, -1.1292634010314941, 0.03265558183193207, -0.38423964381217957, 0.2640922963619232, 0.2604300379753113, 0.56393963098526, -0.23012234270572662, 0.006359702907502651, 0.12301228195428848, 0.28207945823669434, 0.3543875217437744, -0.06826253235340118, -0.11567721515893936, -0.1873382031917572, -0.44594794511795044, -0.38613808155059814, 0.6739146709442139, -0.41498303413391113, -0.09712641686201096, -0.47630587220191956, -0.18006882071495056, 0.25183701515197754, -0.49009469151496887, 0.21806441247463226, -0.2693140208721161, -0.6709341406822205, -0.40132153034210205, 0.20093336701393127, 0.03693413361907005, -0.06081109866499901, -0.08309948444366455, 0.0955096185207367, 0.36351773142814636, -0.08734853565692902, 0.16459625959396362, 0.2702261805534363, -0.16373363137245178, 0.09386793524026871, -0.10048746317625046, -0.09686482697725296, 0.3269241750240326, 0.45403072237968445, 0.33636200428009033, 0.28740233182907104, -0.392905056476593, 0.3279644846916199, -0.23200653493404388, 0.634541928768158, -0.5662176012992859, -0.054235562682151794, 0.032030120491981506, -0.25487810373306274, 0.8384509682655334, 0.8505477905273438, -0.11467213183641434, 0.5073806643486023, 0.5037766695022583, -0.020766235888004303, 0.6280675530433655, -0.38187822699546814, -0.33910924196243286, -0.5309181809425354, 0.06006411463022232, -0.1493673324584961, 0.7498762011528015, -0.3565167188644409, -0.5767996311187744, 0.16058437526226044, 0.39028215408325195, 0.05847218260169029, -0.33091580867767334, 0.054608557373285294, -0.5371992588043213, 0.32190239429473877, -0.5232880711555481, -0.01943228393793106, -0.9012945890426636, -0.09720773994922638, -0.20691300928592682, 0.1169547289609909, -0.009229393675923347, 0.16084621846675873, -0.2874981760978699, -0.13533103466033936, 0.4238356351852417, 0.022750742733478546, 0.45670998096466064, 0.15531250834465027, -0.2593972086906433, -0.9257689118385315, -0.22172261774539948, -0.0192220751196146, -0.1922861784696579, 0.2741011381149292, -0.31849387288093567, 0.1674129068851471, 0.09787371754646301, -0.6088026165962219, -0.023100506514310837, -0.4172515273094177, 0.26582565903663635, 0.19170527160167694 ]
Polycomb group (PcG) proteins form multiprotein complexes, called Polycomb repressive complexes (PRCs). PRC2 contains the PcG proteins EZH2, SUZ12, and EED and represses transcription through methylation of lysine (K) 27 of histone H3 (H3). Suz12 is essential for PRC2 activity and its inactivation results in early lethality of mouse embryos. Here, we demonstrate that Suz12(-/-) mouse embryonic stem (ES) cells can be established and expanded in tissue culture. The Suz12(-/-) ES cells are characterized by global loss of H3K27 trimethylation (H3K27me3) and higher expression levels of differentiation-specific genes. Moreover, Suz12(-/-) ES cells are impaired in proper differentiation, resulting in a lack of repression of ES cell markers as well as activation of differentiation-specific genes. Finally, we demonstrate that the PcGs are actively recruited to several genes during ES cell differentiation, which despite an increase in H3K27me3 levels is not always sufficient to prevent transcriptional activation. In summary, we demonstrate that Suz12 is required for the establishment of specific expression programs required for ES cell differentiation. Furthermore, we provide evidence that PcGs have different mechanisms to regulate transcription during cellular differentiation.
[ -0.005570497829467058, -0.004770189523696899, -0.004486517980694771, 0.019617261365056038, 0.005886182654649019, -0.011215098202228546, 0.012888705357909203, -0.0007842321647331119, -0.013621341437101364, -0.008744452148675919, -0.0032909756992012262, -0.004585561342537403, -0.0005913778441026807, 0.011710886843502522, 0.016375314444303513, -0.012357551604509354, -0.01495106890797615, -0.01616508886218071, 0.01692454144358635, 0.026309741660952568, 0.029950376600027084, -0.0028626280836760998, 0.009686281904578209, 0.0030246516689658165, 0.005796400830149651, -0.012341194786131382, 0.04934525489807129, -0.006085596978664398, -0.034193255007267, -0.006812587846070528, 0.032911643385887146, -0.0059023392386734486, 0.003009694628417492, -0.00509804580360651, -0.010995120741426945, 0.011875564232468605, -0.009021490812301636, 0.023022998124361038, 0.04590769484639168, -0.005956460256129503, -0.018401123583316803, -0.013537878170609474, -0.0008241921896114945, -0.01611967571079731, -0.00915321335196495, -0.010502648539841175, -0.004175196401774883, 0.0024931756779551506, -0.0056801969185471535, 0.005219188518822193, -0.0037427041679620743, -0.010558986105024815, -0.01564084365963936, 0.004050659015774727, -0.006139389239251614, -0.02528420463204384, 0.01822679676115513, 0.015046890825033188, 0.011370528489351273, -0.014215346425771713, 0.0004049123963341117, -0.011933853849768639, 0.020901069045066833, 0.00019986712140962481, 0.0025244844146072865, -0.06667307764291763, 0.0377175435423851, 0.04230520501732826, -0.017131943255662918, 0.018858663737773895, -0.010749305598437786, 0.00919171329587698, -0.01714494451880455, 0.006590882781893015, -0.020243454724550247, -0.03582681342959404, -0.011059548705816269, -0.004556870087981224, 0.008122703060507774, -0.012638849206268787, -0.02983582764863968, -0.042054466903209686, -0.02145790308713913, -0.011352701112627983, 0.009462296031415462, 0.016536351293325424, -0.02673346921801567, 0.009697714820504189, -0.0053476616740226746, 0.007416300941258669, 0.033487048000097275, 0.005990706849843264, -0.0007026931270956993, -0.010215776972472668, -0.008478363044559956, 0.03048051707446575, -0.010679446160793304, -0.028257783502340317, 0.015217848122119904, -0.00864656176418066, -0.02345673367381096, -0.01438684482127428, 0.015733839944005013, 0.01541320700198412, -0.0011942205019295216, 0.00989026390016079, 0.01730332523584366, 0.01415780559182167, 0.027494730427861214, 0.013446012511849403, -0.019045736640691757, 0.049859777092933655, -0.011492511257529259, -0.003785691224038601, -0.02050216868519783, 0.026318076997995377, 0.01268034614622593, -0.005352276377379894, 0.019840825349092484, -0.0068966057151556015, -0.005632311105728149, 0.005956301465630531, -0.005229871720075607, 0.0018568567465990782, 0.00609250646084547, -0.019112974405288696, 0.022991765290498734, 0.01184044685214758, -0.01266008522361517, 0.0023786420933902264, -0.008697180077433586, 0.006750189233571291, -0.021207569167017937, 0.03278234228491783, 0.005430363584309816, -0.011481540277600288, -0.002626249333843589, -0.006218604277819395, -0.009931239299476147, -0.018421800807118416, 0.029057450592517853, 0.007135295309126377, 0.008830640465021133, 0.011866780929267406, 0.003539332188665867, 0.003978534135967493, -0.022371595725417137, -0.001325981575064361, 0.022043805569410324, -0.034011077135801315, 0.03655306249856949, 0.008065851405262947, -0.0075920685194432735, -0.021754728630185127, 0.006840880494564772, 0.003779502585530281, -0.010507171973586082, -0.0015266805421561003, 0.000981192453764379, 0.011424168944358826, -0.03614296019077301, -0.009281733073294163, 0.030645642429590225, 0.010080930776894093, 0.0004046172834932804, -0.02173454314470291, -0.012820761650800705, -0.0025155534967780113, -0.0029451025184243917, 0.005043310113251209, 0.0028332052752375603, -0.017762869596481323, 0.005747980438172817, 0.0009025282924994826, -0.0043518380261957645, -0.007560489699244499, 0.010282889008522034, 0.006332061719149351, -0.014878988265991211, 0.06643091142177582, -0.022548899054527283, 0.02610195428133011, -0.0029129490721970797, 0.00223178812302649, -0.0024431562051177025, -0.010526970960199833, -0.004512281157076359, -0.005515937693417072, -0.029070120304822922, 0.007379321381449699, 0.0018254148308187723, 0.012120517902076244, -0.004594551865011454, 0.011685477569699287, -0.006396723911166191, 0.003862888552248478, -0.01585179939866066, 0.014715243130922318, 0.029613707214593887, -0.01926187053322792, 0.0051323529332876205, 0.0033507863990962505, 0.003655195003375411, -0.007841999642550945, -0.030188394710421562, 0.004754038527607918, -0.01633722148835659, -0.013308127410709858, -0.017221124842762947, 0.0006732556503266096, 0.027245013043284416, -0.018603021278977394, -0.023472582921385765, -0.012930408120155334, -0.028923198580741882, 0.0008538052788935602, -0.031810909509658813, -0.007787616457790136, 0.012716809287667274, -0.010432284325361252, -0.006411448121070862, 0.004487031139433384, 0.00287745613604784, -0.04012959450483322, 0.026627492159605026, -0.014314724132418633, -0.0024666208773851395, 0.010788505896925926, 0.013805716298520565, 0.0008089672774076462, 0.017587505280971527, -0.003948973957449198, -0.017643870785832405, -0.004492826759815216, 0.0315614715218544, 0.011002279818058014, 0.01608373038470745, -0.015014381147921085, 0.00518923019990325, -0.005830386653542519, -0.017783530056476593, 0.007315990515053272, 0.03945869952440262, -0.04057301953434944, 0.022370101884007454, -0.02228141762316227, 0.004139874130487442, 0.0022499472834169865, 0.026070622727274895, -0.018928945064544678, 0.01075764186680317, 0.0021061724983155727, 0.02896236628293991, -0.019264599308371544, 0.0023790430277585983, -0.017690159380435944, -0.01282716915011406, 0.02393203228712082, 0.026209309697151184, -0.02375573292374611, -0.0068289730697870255, 0.009728897362947464, -0.029157303273677826, 0.030727438628673553, 0.0035018136259168386, 0.00041274260729551315, 0.029147334396839142, 0.02919839695096016, -0.000330253504216671, -0.025012332946062088, 0.012523263692855835, -0.00857278797775507, -0.006585912778973579, -0.0816497653722763, -0.01031605526804924, -0.003940962255001068, 0.002364947460591793, 0.004361884202808142, 0.0028130467981100082, 0.015526406466960907, -0.02536879852414131, -0.009382111951708794, -0.006691602058708668, -0.013391168788075447, -0.01140090823173523, -0.009914405643939972, -0.004190295003354549, 0.005207013804465532, -0.013099277392029762, 0.00830892100930214, -0.012131448835134506, 0.00006331817712634802, -0.006895409431308508, 0.012317870743572712, 0.014299958944320679, -0.01393510214984417, -0.005144264083355665, -0.03785496950149536, 0.00993652455508709, -0.009108787402510643, 0.0003610914573073387, 0.027758758515119553, -0.003037725342437625, -0.031924858689308167, 0.016221508383750916, 0.007373950909823179, -0.014837464317679405, 0.02011820860207081, 0.009269220754504204, -0.028741924092173576, 0.013602806255221367, -0.023747269064188004, 0.03699938580393791, -0.06209951266646385, -0.005737747997045517, 0.01211569830775261, -0.007952609099447727, -0.009433712810277939, 0.013668898493051529, 0.038801081478595734, 0.040255703032016754, 0.022801605984568596, 0.005980039015412331, -0.0008200081065297127, -0.0002681870246306062, -0.0007683495059609413, 0.016238577663898468, -0.019128605723381042, -0.003557959571480751, 0.00007823528721928596, 0.015517381951212883, -0.009502490051090717, -0.00443541444838047, -0.009449606761336327, 0.029795192182064056, 0.006547408178448677, -0.013414309360086918, 0.006727143190801144, -0.005865155719220638, 0.009708795696496964, -0.0007221295963972807, -0.025390909984707832, -0.006164995487779379, 0.002528464887291193, 0.009758287109434605, -0.04433118551969528, -0.01171882078051567, -0.020754855126142502, -0.015559878200292587, -0.016862716525793076, -0.013766754418611526, 0.01103927195072174, -0.01915333978831768, -0.012570145539939404, -0.006711418740451336, 0.001066052820533514, 0.0027321181260049343, -0.017748847603797913, -0.016632812097668648, 0.012730845250189304, 0.008110376074910164, 0.00899887178093195, -0.01203148253262043, 0.008881842717528343, 0.02351170964539051, -0.004076861776411533, 0.010888701304793358, -0.014590657316148281, -0.03180883824825287, 0.019724834710359573, 0.003174035344272852, 0.017209218814969063, 0.009164389222860336, -0.05854331701993942, -0.0024092711973935366, -0.022204892709851265, -0.007263260427862406, -0.03495319187641144, 0.011114217340946198, -0.031547870486974716, -0.021429449319839478, 0.008991770446300507, 0.0006000092253088951, -0.014251010492444038, -0.014240367338061333, -0.007177797611802816, 0.03161977231502533, 0.005379045382142067, 0.014751051552593708, -0.01470852643251419, 0.007022579666227102, 0.07196398079395294, -0.006088927388191223, -0.006090584676712751, -0.01876484975218773, -0.006409219466149807, -0.03721146658062935, -0.007344656623899937, 0.009935143403708935, 0.021516645327210426, 0.037681832909584045, 0.013695960864424706, -0.025367334485054016, -0.001000700518488884, -0.000984197948127985, -0.01388559304177761, 0.02178272232413292, -0.024333925917744637, -0.0080493725836277, 0.01281855907291174, 0.02247326448559761, -0.016338514164090157, -0.030841436237096786, 0.003388491924852133, -0.00793493539094925, -0.008642802946269512, -0.0368952751159668, -0.01567879691720009, -0.013870418071746826, -0.009886389598250389, 0.015960045158863068, 0.018072959035634995, -0.028081893920898438, -0.014659497886896133, 0.02587100863456726, 0.022023720666766167, 0.0232803113758564, 0.013277973979711533, -0.009411095641553402, -0.01916162297129631, 0.011669597588479519, 0.028483465313911438, -0.024259524419903755, 0.0048260679468512535, 0.0026598526164889336, -0.007780039682984352, -0.010201839730143547, 0.038883619010448456, -0.009047077037394047, 0.005531500093638897, -0.012468604370951653, -0.003215768141672015, 0.011160295456647873, 0.011015811935067177, -0.007408009842038155, 0.0007925776299089193, 0.01623922772705555, 0.0006676674820482731, -0.01783771812915802, 0.005679012276232243, -0.0042564296163618565, -0.03142252564430237, -0.0040754517540335655, 0.010906772688031197, -0.012602207250893116, 0.006896013393998146, -0.01334998570382595, 0.009614652022719383, -0.0030881562270224094, -0.001934505533427, -0.0069974614307284355, 0.024713482707738876, -0.0013118647038936615, -0.0014294860884547234, -0.012759365141391754, -0.006347947753965855, 0.017171379178762436, 0.016816558316349983, -0.008862541988492012, 0.016436949372291565, -0.011988235637545586, -0.01904795505106449, 0.021889597177505493, 0.011930346488952637, -0.03999035432934761, -0.0012798404786735773, -0.003807276953011751, -0.016603905707597733, -0.07452597469091415, -0.0184612013399601, -0.03529593348503113, -0.0009588634711690247, 0.006283627822995186, 0.023337267339229584, -0.018667850643396378, 0.0003445420879870653, -0.02282116562128067, -0.00752547662705183, 0.010367501527071, -0.007602057885378599, 0.004669200628995895, 0.007803425658494234, 0.011652813293039799, -0.00931968167424202, 0.008944264613091946, -0.009297910146415234, -0.0150742307305336, -0.004277431406080723, -0.015711409971117973, -0.012572484090924263, -0.015257539227604866, -0.016774289309978485, -0.01830856129527092, -0.08093026280403137, -0.009894340299069881, 0.017667043954133987, -0.007263669744133949, -0.011560333892703056, -0.0009774916106835008, 0.013188188895583153, -0.012331971898674965, -0.022495627403259277, -0.013003123924136162, -0.016055360436439514, 0.015495182015001774, 0.0055212895385921, -0.019912447780370712, 0.009107744321227074, -0.0071278344839811325, 0.007726679090410471, 0.0054197232238948345, -0.012859819456934929, -0.01458866335451603, -0.026827093213796616, -0.017159225419163704, -0.011640610173344612, -0.017521429806947708, -0.0038165771402418613, -0.0055342246778309345, -0.01697145216166973, 0.021983139216899872, -0.004879098851233721, -0.01287874672561884, -0.009933631867170334, 0.00872686319053173, -0.03325241059064865, -0.027816014364361763, 0.016683319583535194, -0.027180954813957214, -0.0011964351870119572, 0.007497632410377264, -0.0066704461351037025, -0.02244630642235279, 0.00024639832554385066, 0.011690866202116013, -0.03536684811115265, -0.0010282108560204506, 0.005021090619266033, -0.00539802573621273, 0.007236378267407417, -0.015029216185212135, 0.026450257748365402, -0.024100065231323242, 0.01829652301967144, -0.007109220139682293, -0.018832895904779434, 0.02070348523557186, 0.017851755023002625, 0.0009831993374973536, -0.004410858266055584, 0.015492426231503487, 0.007117673754692078, 0.019753877073526382, 0.013754087500274181, 0.013464147225022316, -0.015802839770913124, 0.07147707045078278, -0.03614325821399689, 0.0062635112553834915, -0.0390983410179615, 0.01963474042713642, 0.0067016612738370895, 0.025889310985803604, -0.023484010249376297, 0.00308952946215868, -0.0014392421580851078, -0.011851983144879341, -0.01782066747546196, -0.03845338895916939, 0.01583990454673767, 0.022169170901179314, -0.005348159931600094, -0.015635307878255844, -0.008651243522763252, -0.01502318400889635, 0.01965920254588127, -0.013072649016976357, -0.006874344311654568, 0.03543739765882492, 0.020299524068832397, 0.024293148890137672, 0.0009272078750655055, -0.013862716034054756, 0.01957259699702263, -0.013684328645467758, -0.01124375220388174, -0.012582462280988693, -0.030024882405996323, 0.004999764263629913, 0.04227731376886368, 0.017856651917099953, 0.032010242342948914, 0.01636866293847561, 0.016875380650162697, -0.013061486184597015, 0.006331584416329861, -0.03220999985933304, -0.003048224374651909, 0.005074257496744394, 0.024182379245758057, 0.01030303630977869, -0.023089274764060974, 0.005742196924984455, -0.002426933031529188, -0.0032944800332188606, 0.0005075429799035192, 0.03535018116235733, -0.0017830245196819305, 0.03038059175014496, 0.009636635892093182, 0.004561504349112511, 0.012815084308385849, -0.022819891571998596, 0.009617249481379986, -0.03534543514251709, 0.008207220584154129, 0.029747379943728447, 0.009260501712560654, 0.03037296235561371, -0.0077868858352303505, 0.05483051389455795, 0.005847809370607138, 0.015575166791677475, -0.00985789392143488, 0.0012627523392438889, 0.017192866653203964, -0.03606344759464264, 0.021057648584246635, 0.010262720286846161, -0.0005329640116542578, 0.023111587390303612, 0.02946649119257927, 0.007662052754312754, -0.001705255126580596, 0.026443753391504288, -0.0027431505732238293, -0.022122424095869064, -0.0039032408967614174, -0.011805081740021706, -0.022372998297214508, -0.013616936281323433, -0.013863317668437958, 0.012358948588371277, 0.0005414092447608709, 0.004758991301059723, 0.011727512814104557, 0.05427483841776848, 0.016979482024908066, 0.009658967144787312, 0.0067923590540885925, 0.007968616671860218, 0.03495750576257706, 0.05153585597872734, 0.006105559878051281, -0.017585670575499535, -0.003969818353652954, 0.011166520416736603, 0.004673448391258717, -0.006824927404522896, 0.012198151089251041, -0.023709021508693695, -0.0013378453440964222, -0.004889515228569508, 0.002277557272464037, 0.010065719485282898, -0.041065338999032974, 0.010283555835485458, -0.014102259650826454, -0.005523561500012875, 0.01362564042210579, 0.014278015121817589, 0.04573633521795273, -0.022786395624279976, -0.0018472447991371155, -0.00040819495916366577, -0.01790992170572281, -0.004393569193780422, 0.002150188898667693, -0.007142237387597561, -0.005218107718974352, 0.017403271049261093, -0.033422280102968216, -0.008683433756232262, 0.015738505870103836, 0.025142772123217583, -0.006978456862270832, 0.024370353668928146, 0.014291951432824135, -0.003921360243111849, -0.01594134420156479, -0.00031964248046278954, 0.0177204217761755, -0.008939540013670921, 0.013164428994059563, -0.004861576482653618, -0.0005680012982338667, 0.005918226670473814, -0.0028037114534527063, 0.009055625647306442, 0.00754938181489706, 0.006193316541612148, -0.001307270722463727, 0.024370752274990082, 0.042235687375068665, -0.0034956797026097775, -0.008980074897408485, 0.03319419175386429, -0.010568046942353249, -0.01842726767063141, -0.007178341969847679, 0.009105823934078217, 0.014872144907712936, 0.007363767363131046, -0.036038532853126526, -0.013321202248334885, -0.002265737857669592, 0.0004180753603577614, -0.007683714386075735, -0.008955410681664944, -0.014462852850556374, -0.006827532313764095, -0.012744040228426456, 0.006822812370955944, 0.021781742572784424, 0.003525194711983204, -0.006070008035749197, 0.02800200879573822, 0.006475802510976791, 0.026585496962070465, 0.009075555950403214, -0.03395151346921921, -0.004765276797115803, -0.008755244314670563, 0.004996401257812977, -0.0017616567201912403, 0.02903272584080696, 0.006549396086484194, 0.014467887580394745, 0.017672087997198105, -0.012756312265992165, 0.007525427732616663, -0.0019326119218021631, -0.00517655536532402, -0.019740629941225052, -0.005967751611024141, 0.0012331779580563307, -0.004218257963657379, -0.028711283579468727, -0.03060758486390114, 0.016639266163110733, -0.03490278497338295, -0.005961696617305279, 0.010485528036952019, 0.02119210734963417, 0.02062283270061016, 0.009766565635800362, -0.013259295374155045, -0.006673153024166822 ]
[ 0.12868085503578186, 0.24312858283519745, 0.19299384951591492, 0.1999480128288269, 0.08249618113040924, -0.2581027150154114, -0.289936900138855, 0.16934728622436523, -0.497432142496109, 0.12357503175735474, -0.042707931250333786, -0.13334237039089203, -0.6078047156333923, 0.22959113121032715, -0.1341477930545807, 0.6164935231208801, 0.32110151648521423, 0.11745012551546097, 0.004338564816862345, -0.6781891584396362, 0.09135646373033524, -0.41456249356269836, 0.33676275610923767, -0.09862101823091507, 0.28799113631248474, 0.47636696696281433, -0.010451569221913815, -0.3080633878707886, 0.7851998805999756, -0.26407620310783386, -0.0360649935901165, 0.3244074285030365, 0.4076147973537445, 0.5183435082435608, 0.11003217101097107, 0.03002394177019596, -0.8455766439437866, -0.1579049676656723, 0.11084286123514175, -0.07358679920434952, -0.1347411721944809, -0.44918495416641235, -0.3794756531715393, 0.48812156915664673, 0.2459876388311386, -0.06804993748664856, -1.1800529956817627, 1.273560881614685, -0.038688354194164276, -0.09866438060998917, -0.500644862651825, 0.4574614465236664, 0.3657362759113312, -0.06216913461685181, 0.3850356936454773, 0.04846915230154991, -0.524972677230835, -0.26631906628608704, 0.314100444316864, -0.5404448509216309, -0.35563740134239197, 0.11365729570388794, -0.3147278130054474, 0.2856798470020294, 0.2060297727584839, 0.6252148151397705, -0.06287302076816559, -0.2986493706703186, -0.7660804390907288, -0.23943659663200378, 0.0604134239256382, -0.0034888656809926033, 0.09696682542562485, 0.4791317284107208, 0.04250847548246384, 0.21654272079467773, -0.44728296995162964, -0.30800628662109375, 0.577802836894989, 0.026812292635440826, -0.07894563674926758, 0.002874853555113077, 0.10066218674182892, 0.4110758900642395, 0.26617613434791565, 0.16070662438869476, -0.6995245814323425, 0.3369258642196655, -0.2658946216106415, 0.05925813689827919, -0.20989441871643066, 0.06318368017673492, 0.4344591200351715, 0.27759605646133423, 0.0037668300792574883, 0.2982630729675293, -0.19459836184978485, -0.09978459030389786, 0.009081365540623665, -0.2371576577425003, -0.5702146887779236, 0.4307693541049957, -0.0072548105381429195, -0.6286701560020447, -0.40488746762275696, -0.3955201506614685, -0.10967663675546646, -0.7248566150665283, -0.34308648109436035, 0.08859150856733322, -0.5522916316986084, -0.2099243849515915, -0.591986358165741, -0.1259823441505432, 0.11367350071668625, 0.4023527204990387, 0.0059989881701767445, -0.40994229912757874, 0.5467534065246582, 0.0016270275227725506, -0.524919867515564, 1.2836216688156128, -0.32873719930648804, 0.4030878245830536, 0.22423575818538666, -0.32305827736854553, -0.08330811560153961, -0.1723305732011795, -0.5269144177436829, 0.43835514783859253, 0.027018969878554344, 0.9196351170539856, -0.5375271439552307, 0.21078051626682281, 0.07354633510112762, -0.11414188891649246, 0.3133573830127716, -0.15727683901786804, 0.6071232557296753, 0.34974274039268494, -0.5501604080200195, -0.6890490651130676, -0.06747571378946304, 0.0753389373421669, -0.2456045150756836, -0.1747235357761383, -0.3567885756492615, -0.20648445188999176, -0.28401413559913635, -0.5388231873512268, -0.17625263333320618, -0.6594608426094055, -0.48229914903640747, -0.3722696900367737, -0.0674431324005127, 0.19646765291690826, 0.3798280954360962, 0.02464388683438301, -0.17830629646778107, -0.022950254380702972, 0.20057909190654755, -0.17684096097946167, -0.4336651861667633, -0.28615549206733704, 0.4268655776977539, -0.21335427463054657, 0.47288084030151367, 0.30965250730514526, -0.06083106994628906, -0.04897310584783554, -0.10588309168815613, -0.45194318890571594, 0.275797963142395, -0.33344489336013794, -0.2120349258184433, -0.29492616653442383, 0.2790455222129822, -0.265941321849823, 0.18024109303951263, -0.16218924522399902, -0.9204565286636353, -0.01145380549132824, -0.6716302633285522, -0.2898591458797455, 0.14368507266044617, 0.47291359305381775, 0.6826038956642151, -0.0779043659567833, -0.20640717446804047, 0.025953732430934906, -0.1376902461051941, -0.08870311081409454, 0.8702896237373352, -0.13583800196647644, 1.520796298980713, -0.14983177185058594, -0.2545539140701294, 1.2098371982574463, 0.36977383494377136, 0.3819292187690735, -0.8990541100502014, 0.369082510471344, 0.3221798837184906, -0.44907936453819275, -0.27391916513442993, 0.26086869835853577, 0.02384834736585617, 0.14246712625026703, 0.1921830028295517, -0.2624925673007965, -0.2540851831436157, -0.38626107573509216, 0.2199464589357376, 0.17716099321842194, 0.3760260045528412, -0.8613933324813843, 0.131842240691185, -0.1269090622663498, -0.3217158019542694, -0.28143176436424255, 0.5461044907569885, -0.6639003753662109, 0.25899800658226013, 1.1224417686462402, -0.49845966696739197, 1.1261745691299438, 0.6897256970405579, 0.15752600133419037, 0.4208781123161316, 0.2050611972808838, 0.18854348361492157, -0.6049094796180725, 0.23478330671787262, -0.19515419006347656, -0.17296183109283447, 0.2822060286998749, 0.2568635046482086, -0.24415411055088043, -0.05949002876877785, -0.23328305780887604, -0.38300395011901855, 0.27284446358680725, -0.5191577672958374, -0.6151356101036072, -0.034381214529275894, -0.4401794672012329, -0.1873081922531128, 0.44252750277519226, -0.7255771160125732, 0.11510265618562698, -0.01259668916463852, 0.2898784875869751, 0.13761816918849945, -0.557296872138977, 0.03740840405225754, 0.0787561684846878, 0.1709764450788498, -0.4243640601634979, -0.09570606797933578, -0.5075320601463318, -0.36517423391342163, -0.314037024974823, -0.040323786437511444, -0.12620587646961212, -0.10884863138198853, -0.21257086098194122, -0.400481253862381, 0.13072015345096588, 1.3945482969284058, 0.44098061323165894, 0.43180838227272034, -0.43149271607398987, -0.9138111472129822, -0.12871474027633667, 0.07400840520858765, -0.26096343994140625, -0.24562452733516693, 0.337838739156723, 0.10449443757534027, -0.4385025203227997, -0.3021045923233032, -0.2682458758354187, 0.5611478686332703, 0.03561721369624138, -0.32720139622688293, 0.35864323377609253, -0.20855051279067993, -0.308379590511322, -0.18766266107559204, -0.6355634331703186, -0.15718062222003937, 0.643290102481842, -0.30624163150787354, 0.03647886589169502, 0.20324867963790894, 0.18109895288944244, -0.3053172528743744, 0.02990681119263172, 0.6249176859855652, 0.27172842621803284, -0.33543702960014343, 0.5242367386817932, 0.0063598849810659885, -0.24034282565116882, 0.272000789642334, 0.4582098722457886, 0.01586456410586834, 0.041440654546022415, -5.7381272315979, 0.02390986494719982, -0.07089345157146454, -0.5136286020278931, -0.16216465830802917, -0.4161764085292816, 0.9666855931282043, -0.044859208166599274, 0.5512083768844604, 0.252019464969635, -0.20946845412254333, 0.07508424669504166, -0.5208852887153625, -0.027226027101278305, -0.06672655045986176, 0.32650429010391235, 0.35525357723236084, -0.1294184923171997, 1.0548757314682007, 0.31631937623023987, 0.11579665541648865, -0.19515837728977203, 0.22780190408229828, -0.02242415025830269, -0.18096061050891876, 0.09331109374761581, -0.9191542267799377, -0.1444864571094513, -0.03145809844136238, -0.3948393762111664, -0.12572023272514343, -0.46889981627464294, 0.02655014395713806, -0.07455307990312576, 0.1628854125738144, -0.3152742087841034, -0.15047882497310638, -0.2849520444869995, -0.571107029914856, -0.1414705216884613, 0.7631539106369019, 0.29827818274497986, 0.5764296054840088, -0.11331307888031006, 0.4849002957344055, -0.07481197267770767, -0.2291865050792694, -0.18020512163639069, -0.5477381348609924, 1.0126433372497559, 0.22224968671798706, -0.3354680836200714, 0.3871648609638214, 0.21235866844654083, 0.585170328617096, 0.3794604539871216, 0.24553494155406952, 0.08866296708583832, -0.9677110910415649, -0.11674857884645462, 0.017914671450853348, -0.06631048768758774, -0.30684563517570496, -0.7142581343650818, 0.12899088859558105, 0.1297703981399536, -1.2587836980819702, -0.14386804401874542, 0.3710733950138092, -0.17511947453022003, -0.0675099715590477, 0.22590790688991547, -0.18716774880886078, -0.5175759196281433, 0.726538896560669, -0.04128376394510269, 0.2045135349035263, 0.006620166823267937, 0.017977237701416016, 0.11246129125356674, -0.08715757727622986, 0.19327519834041595, 0.07048167288303375, -0.07697594910860062, -0.01631958782672882, -0.28218865394592285, 0.010382570326328278, 0.4162432849407196, -0.2826768457889557, 0.48489171266555786, 0.5876291990280151, 0.11050380021333694, 0.37436559796333313, 0.6302822232246399, 0.32736867666244507, -0.14257268607616425, 0.36322709918022156, 0.5016371607780457, 0.6782025098800659, -0.07960895448923111, 0.8397806286811829, 0.12380323559045792, -0.5072713494300842, -0.7204068303108215, -0.4780779182910919, 0.18578016757965088, -0.05499144271016121, 0.12405237555503845, 0.48905640840530396, -0.25839346647262573, 0.17408429086208344, 0.02274417132139206, -0.2680913805961609, -0.38879552483558655, 0.6109861135482788, -0.18209214508533478, 0.032398954033851624, -0.20839479565620422, 0.36643368005752563, -0.4986647963523865, 0.1891459971666336, 0.4632609784603119, -0.9202948212623596, 0.4934650957584381, -0.3922916650772095, 0.011291679926216602, 0.07344101369380951, 0.5228588581085205, -0.5377383828163147, 0.04637296125292778, 0.32364019751548767, 0.48315519094467163, -0.197801411151886, -0.30266299843788147, 0.5105630159378052, -0.1279441863298416, -0.5305821299552917, 0.6966056227684021, 0.4556238651275635, 0.26106366515159607, 0.558268129825592, -0.03139328956604004, 0.28715482354164124, 0.38714656233787537, -0.15276862680912018, 0.33684128522872925, -0.01849307492375374, 0.6470317840576172, 0.03928214684128761, 0.15841162204742432, -0.06993871927261353, -0.8002175092697144, 0.22689831256866455, 0.2952876687049866, 0.3399483859539032, 0.3931543827056885, 0.47137942910194397, 0.3992113769054413, 0.5123066902160645, -0.5799379944801331, 0.0534253865480423, 0.4302178621292114, -0.5070087909698486, -0.20414398610591888, -0.1974305808544159, -0.336978942155838, 0.07226480543613434, -0.478238046169281, -0.47553470730781555, 0.13630583882331848, -0.45901188254356384, 0.03185263276100159, 0.0938374400138855, -0.06561365723609924, 0.19002816081047058, -0.20928767323493958, -0.08479494601488113, -0.29427847266197205, -0.030955348163843155, 0.16054686903953552, -0.2569669187068939, -0.17197073996067047, 0.1672511249780655, 0.3072878420352936, -0.04077254235744476, 0.0292070172727108, -0.06980516016483307, -0.07845873385667801, 0.2956255078315735, -0.33953288197517395, 0.03339099884033203, -0.2687723934650421, 0.18330003321170807, -0.129059299826622, 0.0881485641002655, 0.5546532869338989, 0.3786611557006836, 0.5601893663406372, -0.13955101370811462, -0.6171141862869263, -0.1975267231464386, 0.20021112263202667, -0.15544119477272034, 0.1732880175113678, 0.7925602793693542, 0.28384536504745483, -0.11507534235715866, 0.11818375438451767, -0.08695757389068604, -0.25104132294654846, 0.11718102544546127, -0.7072021961212158, 0.15828198194503784, -0.11648482084274292, -0.34458425641059875, 0.005315996240824461, 0.4569948613643646, -0.12541420757770538, -0.42439934611320496, 0.4250422716140747, 0.026408271864056587, 0.11038131266832352, 0.3203231394290924, -0.3795871436595917, -0.22741739451885223, 0.4728318750858307, 0.2603406012058258, -0.3860662579536438, 0.39275890588760376, 0.1630312204360962, -0.06406677514314651, -0.5438783168792725, 0.018149999901652336, -0.09486889094114304, -0.41017836332321167, -0.6438841223716736, -0.5863220691680908, 0.14602532982826233, 0.6223191022872925, 0.8761128187179565, 0.00416950648650527, 0.4774952530860901, -0.14947256445884705, 0.1151508167386055, -0.40565475821495056, 0.5669805407524109, 0.326066792011261, -0.47406306862831116, -0.3037637174129486, -0.059869859367609024, 0.48095518350601196, -0.14223435521125793, 0.13751016557216644, 0.3479488790035248, 1.0806769132614136, 0.6418226957321167, -0.17977429926395416, -0.24376188218593597, -0.36099299788475037, 0.29913532733917236, -0.5276873111724854, 0.2603705823421478, 0.11145476996898651, -0.25800231099128723, 0.21822555363178253, 0.47581496834754944, 0.006414984352886677, -0.4186239242553711, 0.2714572250843048, 0.32901710271835327, -0.10374774783849716, 0.07007509469985962, 0.7040562033653259, 0.5805588960647583, -0.37668249011039734, 0.15780048072338104, -0.32898685336112976, 0.29024648666381836, -0.049163538962602615, 0.18573006987571716, -0.23242413997650146, -0.180465430021286, 0.4514981210231781, -0.2939903438091278, 0.4058254361152649, -0.6098308563232422, -0.12364622205495834, -0.6584932208061218, 0.2548471689224243, 0.1517011672258377, -0.366558313369751, -0.05066917464137077, -0.6748831868171692, -0.6995062828063965, 0.12659066915512085, -0.3045697510242462, 0.3221041262149811, 0.32879355549812317, -0.05427655205130577, 0.621198832988739, -0.6887882947921753, 0.43656039237976074, 0.6095944046974182, -0.42361462116241455, -0.5389859080314636, 0.12309351563453674, -0.22758078575134277, -0.36115050315856934, -0.7396785020828247, 0.2583281397819519, -0.20860686898231506, -0.17507798969745636, 0.43479642271995544, -0.4376766085624695, -0.5961623787879944, -0.08293557167053223, 0.008912128396332264, -0.42979899048805237, 0.35830235481262207, 0.17528130114078522, 0.11097189784049988, 0.6730035543441772, 0.36797139048576355, 0.2118697166442871, -0.30999401211738586, -0.03986556455492973, 0.09703823924064636, 0.1508258581161499, -0.07777722924947739, 0.6136355400085449, 0.17138534784317017, 0.13180813193321228, 0.3665041923522949, 0.7145036458969116, 0.13489286601543427, 0.004853865131735802, -0.27327921986579895, -0.6489884257316589, -0.03291790187358856, 0.13655489683151245, 0.6317558884620667, 0.6876733303070068, -0.4645243287086487, -0.3670390248298645, 0.4246121644973755, 0.01187176164239645, 0.33998918533325195, -0.39858344197273254, -0.2802218496799469, 0.9947556853294373, 0.530379593372345, -0.5362488627433777, -0.4075634181499481, 0.29651257395744324, -0.734795331954956, 0.22363415360450745, 0.26945704221725464, -0.4507160186767578, -0.32310330867767334, 0.10955391824245453, -0.8923113346099854, 0.23074591159820557, -0.22256651520729065, 1.0852540731430054, -0.2520121932029724, -0.1425117403268814, 0.46750134229660034, 0.12550611793994904, 0.5857164263725281, -0.14189636707305908, -0.18412621319293976, 0.019241129979491234, 0.04104224592447281, -0.0004183941928204149, -0.16370870172977448, -0.8207775354385376, 0.022329779341816902, 0.07402919977903366, -0.19784069061279297, -0.02606281079351902, -0.3893670439720154, 0.09221337735652924, -0.08764465898275375, -0.7805023193359375, -0.4727383255958557, -0.30701667070388794, 0.07625151425600052, -0.5050385594367981, -0.16263051331043243, 0.3035467565059662, 0.27115076780319214, -0.7989475727081299, 0.05630441755056381, -0.2042386829853058, 0.06281022727489471, 0.3018133044242859, 0.07934943586587906, 0.1428961455821991, 0.5772689580917358, 0.8258844614028931, -0.1391170620918274, 0.17308689653873444, 0.1397346407175064, 0.34298941493034363, -0.22650036215782166, 0.19000853598117828, -0.43954578042030334, -0.36719998717308044, -0.5698331594467163, -0.43946436047554016, 0.743703305721283, 0.9332893490791321, -0.38336336612701416, 0.7720934748649597, 0.5132659673690796, 0.3350082337856293, 0.16043661534786224, -0.3648057281970978, -0.0836639404296875, -0.3452431857585907, -0.549704909324646, -0.4993104338645935, 0.5382508635520935, 0.23484987020492554, -0.12600980699062347, -0.06412344425916672, 0.6777656674385071, 0.04290514066815376, -0.09943553805351257, 0.5165364742279053, -0.4867183268070221, -0.03501492366194725, -0.14187878370285034, 0.3897080421447754, -0.23315754532814026, -0.2800016403198242, -0.5210039019584656, 0.3376479148864746, 0.06743033230304718, -0.28401899337768555, 0.45444706082344055, -0.05674896016716957, -0.5382358431816101, -0.28232085704803467, 0.1885427087545395, 0.07782074809074402, -0.42152485251426697, -0.7890809774398804, -1.0030336380004883, -0.4014315605163574, 0.21286872029304504, -0.47028791904449463, -0.22300571203231812, -0.13083821535110474, 0.20921874046325684, -0.49605515599250793, 0.1769774854183197, -0.24206215143203735, 0.1354023963212967, 0.1649700254201889 ]
Proteasomes are cylindrical structures that function in multiple cellular processes by degrading a wide variety of cytosolic and nuclear proteins. Substrate access and product release from the enclosed catalytic chamber occurs through axial pores that are opened by activator complexes. Here, we report high-resolution structures of wild-type and mutant archaeal proteasomes bound to the activator PA26. These structures support the proposal that an ordered open conformation is required for proteolysis and that its formation can be triggered by outward displacement of surrounding residues. The structures and associated biochemical assays reveal the mechanism of binding, which involves an interaction between the PA26 C terminus and a conserved lysine. Surprisingly, biochemical observations implicate an equivalent interaction for the unrelated ATP-dependent activators PAN and PA700.
[ 0.005339900963008404, 0.0009344557765871286, 0.005807475186884403, 0.023695383220911026, 0.0022540476638823748, -0.007306871935725212, 0.011458342894911766, 0.014847274869680405, -0.012045653536915779, 0.017151568084955215, -0.013876426964998245, -0.00004354194970801473, -0.016502048820257187, 0.012409396469593048, -0.008255181834101677, -0.00588145200163126, -0.014288445003330708, 0.00035982485860586166, 0.001825761515647173, 0.008160769939422607, 0.005214606411755085, 0.0006804438307881355, 0.011320775374770164, -0.037432245910167694, 0.01173405721783638, -0.0018723239190876484, 0.031202204525470734, -0.00980343483388424, -0.016430318355560303, 0.016353052109479904, 0.02241143211722374, -0.02053641900420189, 0.0019550295546650887, -0.020343773066997528, 0.00906815379858017, -0.0019277562387287617, -0.0033074195962399244, 0.024316631257534027, 0.04899375140666962, -0.004227966070175171, -0.006446959916502237, -0.006382042542099953, 0.0004671806818805635, -0.000901802908629179, -0.012376518920063972, -0.005426306277513504, 0.0018546655774116516, -0.00936038326472044, -0.0041228230111300945, -0.0032255686819553375, -0.006831270642578602, 0.020968571305274963, -0.0017314656870439649, 0.00835983082652092, -0.007474847137928009, -0.023618794977664948, 0.019828198477625847, -0.04215607792139053, 0.014162423089146614, -0.009657359682023525, -0.00929570198059082, 0.03268890082836151, -0.013477824628353119, -0.009566642343997955, -0.0060895513743162155, -0.06672260910272598, 0.016564445570111275, 0.016599223017692566, -0.003104597330093384, -0.02510368824005127, -0.008963000029325485, 0.006435667164623737, -0.014290222898125648, 0.0073969098739326, 0.005874932743608952, -0.008160727098584175, -0.023684615269303322, 0.014006875455379486, 0.018146853893995285, 0.02758074924349785, -0.02569827437400818, -0.003258740995079279, -0.026857344433665276, -0.0006450440268963575, -0.00396099966019392, 0.015945760533213615, -0.013963727280497551, 0.018928997218608856, -0.011432173661887646, 0.0014359430642798543, -0.005985085852444172, 0.024763070046901703, -0.011385394260287285, 0.00955984927713871, 0.004446264822036028, 0.002533331047743559, -0.03126002848148346, -0.011287646368145943, -0.023963628336787224, 0.011107461526989937, -0.010346146300435066, 0.014675850048661232, 0.01429598405957222, 0.01304760854691267, -0.001290610060095787, 0.014204520732164383, -0.005976635031402111, -0.02003125473856926, 0.0402739979326725, 0.01139005459845066, -0.0019944021478295326, 0.008630502969026566, -0.007836638949811459, 0.014095719903707504, -0.0010850296821445227, -0.000643567182123661, 0.0028008020017296076, 0.02402791753411293, 0.008651545271277428, 0.011167682707309723, 0.015254175290465355, -0.017537690699100494, 0.0030990266241133213, 0.01921483874320984, 0.008969578891992569, 0.005161457695066929, 0.0030344785191118717, -0.0005132816731929779, 0.013561987318098545, 0.0029892255552113056, -0.008744555525481701, -0.00266568036749959, 0.015167457982897758, -0.00582285039126873, 0.012939974665641785, 0.0030529231298714876, -0.0003399038687348366, -0.015278127044439316, 0.011068372055888176, -0.005263525992631912, 0.004635831341147423, 0.009367352351546288, 0.008987649343907833, 0.009359669871628284, 0.021011091768741608, -0.005843054968863726, 0.002984905382618308, -0.0089027751237154, -0.015366189181804657, -0.01337343454360962, -0.000140325166285038, -0.000648990273475647, -0.002205616096034646, -0.010083984583616257, 0.005876099690794945, -0.018821701407432556, -0.009067459963262081, 0.0005761184729635715, -0.0039160833694040775, -0.016440514475107193, -0.04202838987112045, -0.00005112728103995323, 0.00016962247900664806, 0.009779497981071472, -0.00755329430103302, -0.022190138697624207, 0.005947721656411886, -0.0006978907622396946, 0.015624676831066608, 0.006903430446982384, -0.003701623296365142, -0.046012647449970245, 0.026236295700073242, 0.005930358078330755, 0.00005993898957967758, 0.006484841462224722, -0.003501421771943569, 0.008257190696895123, -0.022755175828933716, 0.06682014465332031, -0.01269636582583189, 0.04396515339612961, 0.034357279539108276, -0.0005291355773806572, 0.00001378974411636591, 0.014806348830461502, 0.017711739987134933, -0.009329931810498238, -0.00541696697473526, -0.023141425102949142, -0.0012613441795110703, 0.003467344678938389, -0.0045959861017763615, -0.012240277603268623, -0.03821602463722229, 0.004740912467241287, 0.01537267491221428, 0.010998513549566269, -0.003341503906995058, -0.011031952686607838, 0.015913063660264015, -0.003860065946355462, 0.001216756645590067, -0.010534636676311493, 0.006775637157261372, -0.0028364278841763735, -0.01376351062208414, -0.03528411686420441, -0.0005923300050199032, 0.007262225262820721, 0.010046083480119705, -0.0016015092842280865, -0.008864568546414375, -0.011160734109580517, 0.00621267082169652, 0.016535084694623947, -0.012699311599135399, -0.011909736320376396, -0.0014669224619865417, -0.01447619590908289, -0.006900529842823744, -0.0035805581137537956, 0.02671920508146286, -0.007973144762217999, 0.021223723888397217, 0.0016791566740721464, 0.009645409882068634, 0.014422466978430748, -0.015337634831666946, 0.007613739930093288, -0.013178786262869835, -0.0138980932533741, -0.015523428097367287, 0.009612249210476875, -0.006025597918778658, 0.00247760396450758, 0.01309896633028984, -0.021599115803837776, 0.01471383310854435, 0.0010591434547677636, 0.012617582455277443, -0.002988044638186693, 0.0006924457848072052, -0.012985562905669212, 0.00373431877233088, -0.0020076758228242397, 0.01630980893969536, 4.4330954551696777e-7, 0.03750080615282059, -0.010493111796677113, 0.007355853449553251, 0.011085781268775463, -0.007434329949319363, 0.004159906879067421, 0.014827604405581951, 0.015047422610223293, -0.02080175280570984, -0.00958117377012968, 0.025713222101330757, -0.014088129624724388, -0.0003612713480833918, 0.004903033375740051, -0.010176315903663635, -0.03635355457663536, -0.010593279264867306, 0.015469491481781006, 0.0030356531497091055, -0.02370312809944153, 0.020797040313482285, -0.0005557676777243614, 0.009443148970603943, -0.0020172693766653538, 0.006592721678316593, -0.08104252070188522, -0.01661098003387451, -0.006892841774970293, 0.03144450485706329, 0.006248396821320057, -0.0065136682242155075, -0.0022009829990565777, 0.0064672804437577724, -0.0049488842487335205, 0.004101245664060116, -0.0029108268208801746, 0.013774560764431953, -0.004872194025665522, 0.041169214993715286, 0.016727278009057045, 0.0003353432985022664, 0.01576664298772812, 0.000867730937898159, -0.001813243143260479, -0.006518010050058365, 0.019907668232917786, 0.013110063970088959, 0.03059964068233967, -0.00036151823587715626, -0.01926891878247261, 0.0025574518367648125, 0.023716606199741364, 0.004625887610018253, -0.007396239787340164, 0.011399205774068832, -0.01365660224109888, -0.0016536726616322994, -0.009621968492865562, 0.010545773431658745, 0.0019077532924711704, -0.0024859097320586443, 0.007164039649069309, -0.0007269890047609806, -0.020427266135811806, 0.0072984532453119755, -0.004121140111237764, 0.01480930671095848, -0.00733056478202343, 0.026564549654722214, -0.0015202430076897144, 0.010063765570521355, 0.015108905732631683, -0.011981399729847908, 0.02589908242225647, -0.005820371210575104, 0.009199217893183231, 0.009797690436244011, 0.032595194876194, 0.01353752426803112, -0.008705995045602322, 0.028387386351823807, -0.017278412356972694, 0.007354888133704662, -0.006430213339626789, -0.01901843771338463, -0.016830937936902046, -0.00009983894415199757, 0.001124832546338439, 0.022534845396876335, 0.012018461711704731, 0.02006586641073227, 0.021560069173574448, 0.008515704423189163, -0.00989223551005125, -0.001843449310399592, 0.00907830148935318, 0.002800741931423545, -0.009595349431037903, -0.008192555978894234, -0.007129266858100891, -0.009194067679345608, -0.010210523381829262, -0.013135379180312157, -0.025254474952816963, -0.029539158567786217, -0.03286851942539215, -0.0009826590539887547, -0.011000457219779491, 0.01257767342031002, -0.037400271743535995, 0.004347930662333965, 0.009985252283513546, 0.03125239163637161, -0.0014546167803928256, -0.015916211530566216, 0.005542256869375706, -0.011770564131438732, -0.009097745642066002, 0.004706704989075661, -0.017657296732068062, -0.016428839415311813, 0.002954944036900997, -0.0043518734164536, -0.002530251629650593, 0.01119920238852501, -0.01634228229522705, -0.002542100613936782, 0.010170606896281242, -0.014640484936535358, -0.006701331585645676, 0.013480445370078087, 0.011872217059135437, 0.02068590372800827, 0.011481801979243755, 0.0003957701555918902, -0.017587002366781235, -0.004479572176933289, -0.013712752610445023, -0.01653112843632698, 0.008604398928582668, -0.0081715052947402, -0.014908947981894016, 0.015173699706792831, 0.07212959229946136, -0.03400661051273346, 0.013200493529438972, -0.008040985092520714, 0.03280710428953171, -0.004543894436210394, -0.0009077696595340967, -0.01321232970803976, 0.046989768743515015, -0.004687885753810406, 0.01338346116244793, 0.02227124571800232, 0.01937023550271988, -0.018571894615888596, -0.018105801194906235, 0.0024711035657674074, -0.021004624664783478, -0.012204095721244812, 0.020085850730538368, 0.05215338245034218, -0.006633274257183075, -0.00649394653737545, 0.01730218157172203, 0.0011332198046147823, -0.023424290120601654, -0.0157666876912117, -0.020612111315131187, -0.013855453580617905, -0.006398441269993782, 0.010563232935965061, 0.024311961606144905, -0.0063562593422830105, -0.008946172893047333, 0.005569208413362503, 0.0152902752161026, 0.0023112883791327477, 0.01383154559880495, -0.00032433285377919674, 0.0034675616770982742, 0.009326783008873463, 0.030095476657152176, -0.013257142156362534, -0.019309528172016144, 0.013250473886728287, -0.021959440782666206, 0.0011930265463888645, 0.013795501552522182, -0.008136726915836334, 0.0029326407238841057, -0.016222145408391953, -0.016349181532859802, 0.020764004439115524, 0.012818509712815285, -0.007542779669165611, 0.015187970362603664, -0.016674207523465157, 0.018383996561169624, -0.004704145714640617, -0.027364637702703476, -0.012183550745248795, -0.0185079462826252, 0.03332299739122391, 0.01631518080830574, 0.007453266531229019, 0.010735936462879181, -0.014202035032212734, 0.006403406150639057, -0.009140977635979652, 0.006225024349987507, 0.014239970594644547, 0.024629302322864532, 0.043152183294296265, -0.03336351737380028, -0.002952820621430874, -0.014274148270487785, -0.02782886102795601, 0.02814631164073944, 0.000542553374543786, 0.012432167306542397, -0.015116414055228233, 0.024170665070414543, 0.03289917856454849, 0.019722681492567062, 0.0024721084628254175, -0.003348421538248658, -0.04618522897362709, -0.012200604192912579, -0.07466293126344681, 0.008867908269166946, -0.027515994384884834, -0.0028644632548093796, 0.013209686614573002, 0.014783988706767559, -0.000896063691470772, -0.019329529255628586, 0.01557241939008236, -0.008400971069931984, -0.004264019429683685, 0.012391171418130398, 0.01953817531466484, 0.02059094049036503, 0.012270676903426647, -0.047115258872509, -0.002086428925395012, -0.0015204402152448893, -0.0036651736591011286, -0.009204024448990822, 0.0016240449622273445, 0.02920898050069809, -0.017124563455581665, -0.0058985743671655655, 0.005757723934948444, -0.08111021667718887, -0.007017175666987896, -0.0035325167700648308, -0.0036768848076462746, -0.012380882166326046, -0.012609563767910004, 0.0012142020277678967, 0.0019472579006105661, -0.013645289465785027, -0.013241881504654884, -0.00026277732104063034, 0.008450645953416824, 0.0022999451030045748, -0.006822141818702221, 0.0036481458228081465, -0.004562308546155691, 0.0028067342936992645, 0.00827252771705389, -0.02918771095573902, 0.019228123128414154, -0.009074642322957516, 0.005321851000189781, -0.012658852152526379, -0.003124091774225235, -0.0073689366690814495, -0.011485469527542591, -0.009888017550110817, 0.00857849232852459, 0.002987865125760436, -0.016927434131503105, -0.01147959940135479, 0.00946691632270813, -0.014251194894313812, -0.06488178670406342, -0.0011164704337716103, -0.024003606289625168, -0.018998760730028152, 0.011609934270381927, 0.011258255690336227, -0.009294586256146431, -0.00866260938346386, -0.014053672552108765, -0.01710953377187252, 0.0021510024089366198, 0.0035758228041231632, -0.0036455001682043076, 0.00637370441108942, -0.005235543008893728, 0.022459253668785095, 0.012917153537273407, 0.01776151731610298, -0.007793706841766834, 0.0021241221111267805, -0.003066394245252013, 0.02090192213654518, -0.00218034815043211, 0.0029833666048943996, 0.008169304579496384, 0.035015664994716644, 0.0014678349252790213, -0.00536013999953866, 0.0003754710778594017, 0.01620882749557495, 0.0716153085231781, 0.011472783982753754, -0.0073253195732831955, -0.035834528505802155, 0.020246271044015884, 0.006126482039690018, 0.01158079132437706, -0.03959410637617111, -0.0031106676906347275, -0.003275440074503422, 0.01445159874856472, -0.008625349029898643, -0.02366430126130581, 0.010914601385593414, 0.021001329645514488, -0.0117916539311409, -0.011549688875675201, -0.011024678125977516, -0.006058989558368921, 0.06242268159985542, 0.005451667122542858, 0.004289696458727121, -0.01668017916381359, 0.004889464005827904, 0.002515148837119341, -0.00026791123673319817, 0.00788216944783926, 0.03029930591583252, 0.005810863804072142, 0.027659844607114792, 0.001161688007414341, -0.016286451369524002, 0.0037170471623539925, 0.02875439077615738, 0.012597334571182728, 0.01215284038335085, 0.009012779220938683, 0.0025712433271110058, -0.012983225286006927, 0.00414127204567194, 0.008462561294436455, 0.015468832105398178, -0.0011008859146386385, -0.008488158695399761, 0.004638755228370428, -0.007226350251585245, -0.0020988639444112778, -0.022261042147874832, 0.029993487522006035, 0.022120781242847443, 0.008163558319211006, 0.005520353093743324, 0.007056145463138819, -0.012533493340015411, 0.006819494534283876, 0.003935698419809341, 0.0023775119334459305, 0.0052567822858691216, -0.013202833011746407, -0.012043206952512264, 0.02145027369260788, -0.006118428893387318, 0.008711901493370533, -0.0011329259723424911, 0.010342199355363846, 0.014245517551898956, -0.0019349949434399605, -0.01616821065545082, -0.004403350874781609, 0.017494231462478638, -0.004425032529979944, 0.004394304007291794, 0.006144924089312553, -0.008649218827486038, 0.022023197263479233, 0.01566265895962715, -0.01125754602253437, -0.005032312124967575, 0.02464088797569275, 0.0010497064795345068, -0.00879008136689663, 0.00784587673842907, -0.02709420770406723, 0.010753988288342953, -0.016014065593481064, -0.015993129462003708, -0.01910554990172386, 0.0007327112834900618, 0.007492532953619957, 0.01073380932211876, -0.002033596858382225, -0.010572528466582298, 0.005006404127925634, 0.00648912601172924, 0.003559364937245846, 0.034375712275505066, 0.009100178256630898, 0.007739063818007708, -0.00939498096704483, 0.003740913700312376, -0.011386051774024963, -0.0038825543597340584, -0.021573521196842194, -0.0063613783568143845, -0.01128537580370903, -0.008239188231527805, 0.006049309857189655, 0.002022760920226574, 0.004876039922237396, 0.020738117396831512, -0.011301057413220406, 0.015059932135045528, -0.018899422138929367, -0.006828333251178265, -0.02138371765613556, 0.01618903875350952, -0.02423921599984169, 0.00521499291062355, -0.011441994458436966, -0.007609894499182701, -0.008389207534492016, -0.02648133412003517, -0.031469568610191345, -0.010807586833834648, -0.015228427946567535, -0.02256632037460804, -0.002352955052629113, -0.0038951400201767683, 0.006411030888557434, -0.00014606979675590992, 0.017872709780931473, -0.002609251532703638, -0.017124231904745102, -0.015449745580554008, -0.001291064079850912, 0.01808716356754303, 0.00275548011995852, 0.008438089862465858, 0.01026306301355362, -0.04016254097223282, -0.004882416222244501, -0.014048445038497448, 0.004109678789973259, 0.03384126350283623, 0.008838101290166378, -0.027906974777579308, 0.02893039584159851, 0.010327234864234924, 0.014618976041674614, -0.016627419739961624, 0.02225683443248272, 0.0036962907761335373, -0.01719100959599018, -0.006600538734346628, -0.0030223987996578217, 0.02139843814074993, 0.002744724741205573, -0.0330638587474823, -0.009302719496190548, -0.013825350441038609, -0.0030946850311011076, 0.01730506122112274, 0.003907352220267057, -0.009724765084683895, -0.014749928377568722, -0.005795916076749563, 0.021370086818933487, -0.009231464937329292, 0.010341349989175797, 0.040382660925388336, 0.018678871914744377, 0.0021642022766172886, 0.0009772409684956074, 0.008542897179722786, -0.031261853873729706, -0.01715845614671707, -0.006337917409837246, -0.018531663343310356, 0.006365672685205936, 0.0008314470760524273, -0.007163208909332752, 0.00796998105943203, -0.002274422673508525, -0.006217522546648979, -0.0003106947988271713, -0.014250403270125389, -0.01799793355166912, 0.0015270353760570288, -0.0077206045389175415, 0.007556759752333164, -0.025147464126348495, 0.0026915990747511387, -0.006007850635796785, 0.01872207224369049, 0.009482651948928833, -0.02026299014687538, 0.005686762742698193, -0.055227942764759064, 0.012425449676811695, -0.00882809516042471, -0.008222813718020916, -0.01705993339419365 ]
[ 0.16605444252490997, 0.2536625564098358, 0.3366633653640747, -0.02034335769712925, 0.025811010971665382, 0.030646303668618202, 0.2405676543712616, -0.13402646780014038, -0.2819480895996094, -0.23790772259235382, 0.003046927507966757, -0.33386096358299255, -0.9238501191139221, 0.6937889456748962, 0.3655617833137512, 0.7886063456535339, 0.22883698344230652, 0.3887379765510559, -0.41975101828575134, -0.4109627604484558, -0.3724546432495117, -0.17325302958488464, 1.0209481716156006, -0.19019320607185364, 0.6062747836112976, -0.14035573601722717, 0.23425176739692688, 0.03937751054763794, 0.42807018756866455, -0.10203423351049423, 0.07670698314905167, 0.006647537462413311, -0.04252292215824127, 0.028375715017318726, -0.05483713746070862, 0.024556519463658333, -0.6067812442779541, 0.41895294189453125, 0.102761410176754, -0.26642104983329773, -0.6005369424819946, -0.12720181047916412, 0.056414950639009476, 0.265536367893219, -0.2622458338737488, 0.034717410802841187, -1.064648151397705, 0.7502240538597107, -0.5381050705909729, 0.2765232026576996, -0.14285112917423248, 0.2604539394378662, 0.4485105574131012, 0.04151713475584984, 0.2734191119670868, -0.16059023141860962, -0.6587831377983093, -0.1051846444606781, 0.32827091217041016, -0.9464892745018005, 0.029718002304434776, 0.5487507581710815, -0.34772825241088867, 0.26621320843696594, -0.06975529342889786, 0.5573086142539978, -0.16155868768692017, -0.42118024826049805, -0.6272873878479004, 0.007770100608468056, -0.17249080538749695, -0.5902524590492249, 0.03056909702718258, 0.5959488749504089, 0.18595218658447266, -0.483954519033432, -0.6170833706855774, -0.2204391062259674, 0.10749105364084244, 0.0362786129117012, 0.12740376591682434, 0.25808578729629517, 0.04511447250843048, 0.2734420597553253, 0.6523541212081909, 0.11720917373895645, -0.6020534038543701, 0.4466541111469269, -0.4666280448436737, -0.0690595731139183, -0.19897082448005676, 0.11778626590967178, 0.31062883138656616, 0.2432602196931839, 0.19314560294151306, 0.2731706500053406, 0.41058966517448425, -0.18622274696826935, 0.26359274983406067, 0.4984544515609741, -0.18822035193443298, 0.16194871068000793, 0.20249629020690918, -0.4306682050228119, 0.018699107691645622, -0.06212485954165459, 0.023309821262955666, -0.44913095235824585, -0.2634422481060028, 0.13067777454853058, -0.6811741590499878, -0.10134541988372803, -0.42344895005226135, 0.10945407301187515, 0.1816544234752655, 0.05153490975499153, -0.3559391498565674, -0.3189278841018677, 0.13655120134353638, -0.30311882495880127, -0.40603122115135193, 0.7975475192070007, -0.21556934714317322, 0.5460874438285828, -0.1711777299642563, -0.2914314866065979, -0.4079023599624634, -0.19911712408065796, -0.604491651058197, 0.6989721059799194, 0.7545156478881836, 0.6766592860221863, -0.37726640701293945, 0.4751288890838623, -0.14394131302833557, 0.04560364782810211, 0.3078668415546417, 0.3455164134502411, 0.8120880722999573, -0.36907604336738586, -0.8629985451698303, -0.08937829732894897, -0.34641462564468384, 0.014034587889909744, -0.27380838990211487, -0.5372421145439148, -0.12122298777103424, 0.08886930346488953, -0.4583625793457031, -0.13458719849586487, -0.10299789905548096, -0.5049834847450256, -0.35291025042533875, -0.41237518191337585, -0.24742084741592407, -0.23345176875591278, 0.47238606214523315, 0.010763081721961498, 0.08708218485116959, -0.04274333268404007, 0.15230269730091095, 0.012261682190001011, -0.5575917959213257, 0.0943884626030922, 0.48690712451934814, -0.03625527024269104, 0.5541059970855713, 0.16832636296749115, 0.13634784519672394, 0.39930498600006104, 0.13026461005210876, -0.15720203518867493, 0.18119962513446808, -0.5465798377990723, -0.7714511156082153, -0.13274960219860077, 0.18374748528003693, -0.008737386204302311, 0.2768266499042511, -0.541188657283783, -0.6470389366149902, -0.2637992799282074, -0.26396968960762024, -0.15056870877742767, -0.1500304937362671, 0.036416154354810715, 0.7390310168266296, -0.614633321762085, -0.3351444900035858, 0.21126338839530945, -0.019052453339099884, -0.048118967562913895, 0.33192014694213867, -0.6685078740119934, 1.4937976598739624, -0.3742823898792267, -0.5326184630393982, 0.957903265953064, -0.013896633870899677, -0.12640447914600372, -0.5603670477867126, 0.365499883890152, 0.15416723489761353, -1.0046700239181519, -0.398580938577652, 0.4580526649951935, 0.0734262764453888, -0.10905513912439346, 0.7606164216995239, -0.14422544836997986, 0.3273220956325531, -0.7641934752464294, -0.10744684934616089, -0.25567740201950073, 0.42409420013427734, -0.8778129816055298, -0.08097834885120392, -0.1479278802871704, -0.15862780809402466, -0.07458808273077011, 0.8403185606002808, -0.6142176389694214, 0.5313590168952942, 1.0244419574737549, -0.2708066999912262, 0.35369786620140076, 0.5312657952308655, -0.03245972469449043, 0.5774973034858704, 0.31403231620788574, 0.7000146508216858, -0.4575023055076599, 0.4092744290828705, -0.10780461132526398, 0.29015547037124634, -0.05749323591589928, 0.25178468227386475, 0.10060244053602219, -0.3655646741390228, -0.2563360035419464, -0.18574798107147217, 0.6793693900108337, -0.9441505670547485, -0.549307644367218, 0.202279195189476, -0.7381926774978638, -0.21408849954605103, 0.30897486209869385, -0.7171368598937988, 0.203684464097023, -0.23788318037986755, 0.14972130954265594, -0.076666459441185, -0.7055109739303589, 0.19584974646568298, 0.14018478989601135, -0.6101102232933044, -0.0554710254073143, -0.18837492167949677, -0.36376693844795227, -0.809967041015625, -0.2716134190559387, -0.42225387692451477, 0.3003617823123932, 0.23686617612838745, 0.25815871357917786, -0.010807785205543041, -0.2861991226673126, 1.2666044235229492, 0.8373888731002808, 0.7356788516044617, -0.006432881113141775, -0.7235613465309143, -0.3214690089225769, -0.2578520178794861, -0.1388522982597351, -0.031259533017873764, 0.1229826807975769, 0.008964804001152515, -0.5579268932342529, 0.012699432671070099, -0.2020094394683838, 0.6019965410232544, -0.2415037602186203, -0.22818394005298615, 0.07809752225875854, 0.2627320885658264, -0.17560797929763794, -0.38867515325546265, -0.11316359788179398, -0.3366113603115082, 0.26815032958984375, -0.7985655665397644, -0.02846883237361908, 0.2680932581424713, 0.3322019577026367, -0.1584041267633438, 0.30860456824302673, 1.0169117450714111, -0.30817723274230957, -0.3440263271331787, -0.22598406672477722, -0.5710449814796448, 0.10755639523267746, 0.3834124803543091, 0.007861335761845112, 0.168943390250206, 0.13822785019874573, -5.769146919250488, -0.11476919054985046, -0.23490475118160248, -0.2089574933052063, 0.5228304266929626, -0.1263953596353531, 0.9964108467102051, 0.16922858357429504, 0.16994956135749817, -0.07508483529090881, 0.3598666787147522, 0.2728629410266876, -0.14282460510730743, 0.17030371725559235, 0.17187868058681488, 0.41469329595565796, 0.33679676055908203, 0.29044896364212036, 0.5168754458427429, -0.35167577862739563, 0.23976412415504456, -0.5549931526184082, 0.006324972957372665, 0.23840610682964325, -0.18760289251804352, 0.061088476330041885, -1.0660181045532227, 0.4244474768638611, 0.038442667573690414, -0.35401830077171326, -0.466447651386261, -0.913925051689148, -0.029352262616157532, -0.7603888511657715, 0.36422449350357056, -0.08828318864107132, -0.1626064032316208, -0.07419773936271667, -0.47743725776672363, -0.12513664364814758, 0.7683717012405396, 0.22861717641353607, 0.0751575455069542, -0.06935780495405197, 0.6313573718070984, -0.25596699118614197, -0.19673417508602142, -0.45342880487442017, -0.2387082278728485, 0.9027372598648071, -0.2770632803440094, -0.1340891420841217, 0.856813371181488, 0.2975059747695923, 0.6821047067642212, -0.04141044244170189, -0.10161181539297104, -0.09092977643013, -0.3826165199279785, -0.1970706582069397, -0.12218150496482849, -0.37162265181541443, -0.3816649615764618, -0.7990685105323792, 0.03787270188331604, 0.14516755938529968, -0.6147406101226807, 0.13871969282627106, 0.7306379675865173, -0.1303752213716507, -0.481484979391098, 0.06941717863082886, -0.2500554323196411, -0.47847843170166016, 0.6845172047615051, -0.13389378786087036, 0.5968688726425171, -0.2774474322795868, 0.1449608951807022, -0.13811103999614716, -0.12834405899047852, 0.6108617186546326, -0.16699717938899994, -0.14351779222488403, 0.33833807706832886, -0.416698157787323, -0.11574295908212662, -0.376335471868515, -0.5057231783866882, 0.7171081900596619, 0.07129912078380585, -0.06311868131160736, 0.12283637374639511, 0.39211755990982056, 0.6227801442146301, -0.0681505799293518, -0.10029014945030212, 0.5511634945869446, 0.3487599492073059, -0.12058878690004349, 0.6166519522666931, -0.16399891674518585, -0.4700218439102173, -0.09157507866621017, 0.03843224048614502, 0.2230142205953598, -0.3369808793067932, 0.21911299228668213, -0.04030480608344078, -0.3381930887699127, 0.04730211943387985, 0.28369659185409546, -0.27610138058662415, -0.29158851504325867, 0.44713932275772095, 0.005425129551440477, -0.46067407727241516, 0.29722490906715393, 0.5602725148200989, -0.6485719084739685, -0.2674145996570587, 0.3090379238128662, -0.45843005180358887, 0.3458240330219269, -0.574263334274292, -0.32578861713409424, 0.5297553539276123, 0.3208385109901428, -0.025403078645467758, -0.3575194776058197, 0.41186782717704773, 0.05030464008450508, -0.37567079067230225, -0.40521788597106934, 0.3464405834674835, -0.321792334318161, 0.08726080507040024, 0.2146405428647995, 0.05537403002381325, -0.15384279191493988, -0.2668779492378235, -0.4751417934894562, 0.2671875059604645, 0.06077214702963829, -0.008488114923238754, 0.34076395630836487, 0.10333747416734695, 0.7203839421272278, 0.3323010206222534, 0.0786479189991951, -0.006861979607492685, 0.16386635601520538, 0.4446009397506714, -0.12857294082641602, 0.11448723077774048, -0.30913159251213074, 0.2712191641330719, 0.20835146307945251, 0.5197979807853699, -0.6169200539588928, 0.30203089118003845, 0.23771949112415314, -0.6755823493003845, 0.306242436170578, -0.4958467185497284, -0.17667745053768158, 0.02855602465569973, -0.39530596137046814, -0.48818448185920715, -0.3747926354408264, -0.35512277483940125, -0.13917802274227142, 0.5081159472465515, -0.39948809146881104, -0.06084859371185303, -0.1971752643585205, -0.1818627268075943, -0.07581374049186707, 0.13285915553569794, -0.48309195041656494, -0.0657544881105423, -0.15698260068893433, 0.10726483911275864, 0.3144821226596832, -0.0658140778541565, 0.1579301655292511, -0.35186296701431274, -0.03679290786385536, 0.01664794236421585, -0.4100099205970764, 0.2429879605770111, 0.3379283845424652, 0.49383753538131714, -0.4111138582229614, 0.029259245842695236, 0.0730941891670227, 0.057708725333213806, 0.567290186882019, -0.09743048995733261, -0.6780201196670532, -0.04569000378251076, 0.31480875611305237, -0.3082633316516876, 0.7383255362510681, 0.3268170952796936, 0.5106356739997864, -0.03248978778719902, -0.1526430994272232, 0.31797507405281067, -0.20308569073677063, -0.3954298198223114, -0.20824803411960602, 0.13708673417568207, 0.6702088713645935, -0.3571474254131317, 0.06535488367080688, 0.28784820437431335, 0.27850648760795593, 0.1922241896390915, 0.33118245005607605, 0.6344418525695801, -0.08693370968103409, 0.06084969639778137, 0.21594685316085815, -0.43475663661956787, 0.5763480067253113, 0.7046165466308594, -0.6404554843902588, 0.22668421268463135, -0.03403673321008682, 0.08871781080961227, -0.20194289088249207, -0.1911093294620514, -0.27712637186050415, -0.14388419687747955, -0.2209152728319168, -0.16481728851795197, -0.10479902476072311, -0.24760869145393372, 0.705710232257843, 0.07018763571977615, 0.32346951961517334, 0.0036526299081742764, -0.08252093940973282, 0.0439213290810585, 0.5889517664909363, 0.47210434079170227, -0.6404415965080261, -0.30635008215904236, 0.010153895244002342, 0.623482882976532, -0.047497641295194626, -0.18160797655582428, 0.23503783345222473, 0.9801891446113586, 0.06999203562736511, -0.06714308261871338, -0.446723073720932, 0.12124988436698914, 0.21501821279525757, -0.3170612156391144, -0.04453263059258461, -0.4513370096683502, 0.1771412193775177, 0.22467771172523499, -0.2259809672832489, -0.4866785705089569, -0.6038680076599121, 0.47973790764808655, 0.029628464952111244, 0.05042710527777672, 0.6173393130302429, 0.6533980369567871, 0.4166199266910553, 0.14691312611103058, 0.41726768016815186, 0.4026223123073578, -0.10178425908088684, 0.0454895943403244, 0.22571471333503723, -0.8139379024505615, -0.4506760537624359, 0.3563893139362335, -0.21520793437957764, 0.4069432020187378, -0.9997727870941162, -0.1676192283630371, -0.5580418109893799, -0.21608096361160278, -0.09295585006475449, -0.009340421296656132, 0.1688961386680603, -0.3962726294994354, -0.9358752369880676, -0.08994822204113007, 0.5607264041900635, 0.42533910274505615, 0.008207150734961033, 0.06567750126123428, 0.1306961178779602, -0.6985872983932495, 0.013866552151739597, 0.3404290974140167, -0.7794235944747925, -0.18267010152339935, 0.03528723865747452, 0.01018865592777729, -0.10734593868255615, -0.6374101042747498, 0.0768243595957756, 0.2803960144519806, -0.03537346422672272, 0.361124724149704, -0.13813814520835876, -0.21785469353199005, 0.020227814093232155, 0.32985371351242065, -0.40107882022857666, -0.3290572762489319, 0.4282560646533966, 0.17835716903209686, 0.6102330684661865, 0.12460597604513168, 0.08938907831907272, 0.2650676965713501, -0.09007048606872559, 0.28515398502349854, -0.32468077540397644, -0.7386581301689148, 0.4786391258239746, 0.8164799809455872, -0.040576014667749405, -0.1199730932712555, 0.5252382159233093, 0.3810373544692993, -0.014881134033203125, -0.29742398858070374, -0.4373854398727417, 0.1262546181678772, 0.3228496313095093, 0.3701707124710083, 0.37562888860702515, -0.4307831823825836, -0.02192964032292366, 0.22714993357658386, 0.3411819338798523, 0.2926831543445587, -0.2969191074371338, -0.32313963770866394, 0.8674075603485107, 0.36738380789756775, -0.5380284190177917, -0.14484810829162598, 0.011732339859008789, -0.4795398414134979, -0.005431326571851969, 0.7639323472976685, -0.32268625497817993, -0.3322603404521942, 0.3170691728591919, -0.3683077394962311, 0.4940463602542877, -0.7314466238021851, 0.5678030848503113, -0.2187371701002121, 0.18438120186328888, 0.1378175914287567, -0.6269275546073914, 0.4171447157859802, -0.2445896565914154, 0.5113059878349304, 0.12233006209135056, -0.3902697265148163, 0.2967875897884369, -0.19903941452503204, -0.3525075614452362, 0.09167863428592682, 0.46448108553886414, 0.21457529067993164, 0.3631935715675354, -0.4580998122692108, 0.36427778005599976, -0.194281667470932, -0.40897420048713684, -0.22386318445205688, -0.011504816822707653, 0.0027107822243124247, -0.4114842116832733, 0.19740231335163116, 0.4040676951408386, -0.013233953155577183, -0.6643547415733337, 0.5511288046836853, -0.2101890742778778, 0.1478421539068222, 0.3327077031135559, 0.03146354854106903, 0.33626773953437805, 0.3897130489349365, 0.3803870677947998, -0.3319259285926819, 0.5821775197982788, -0.12971295416355133, 0.23281089961528778, 0.03849582374095917, 0.4810382127761841, -0.41024816036224365, -0.4467957019805908, -0.08355344831943512, -0.023409688845276833, 1.1085236072540283, 0.4858851730823517, -0.12430064380168915, 0.34952569007873535, 0.38583868741989136, 0.23497316241264343, -0.22068369388580322, -0.4094916880130768, -0.0025861600879579782, -0.3827858865261078, 0.2580204904079437, -0.8674970865249634, 0.6037248969078064, 0.1625150591135025, -0.24586579203605652, -0.20893068611621857, 0.5649058222770691, 0.3840102553367615, -0.6005489826202393, 0.7092460989952087, -0.013280736282467842, -0.283665269613266, -0.5623223185539246, 0.09541672468185425, -0.21021431684494019, 0.4468241333961487, -0.4468540549278259, 0.38150742650032043, 0.12317094206809998, -0.49575287103652954, -0.09155452996492386, 0.2519349455833435, 0.26705631613731384, -0.3233855664730072, 0.40347227454185486, -0.06651803851127625, -0.4121907353401184, -0.5887086987495422, -0.8104906678199768, 0.03952017426490784, 0.27506253123283386, -0.2590833604335785, -0.3683414161205292, 0.3184909522533417, -0.12533621490001678, -0.5766330361366272, -0.0065098912455141544, -0.28812354803085327, 0.014497305266559124, 0.12874478101730347 ]
Translational fidelity, essential for protein and cell function, requires accurate transfer RNA (tRNA) aminoacylation. Purified aminoacyl-tRNA synthetases exhibit a fidelity of one error per 10,000 to 100,000 couplings. The accuracy of tRNA aminoacylation in vivo is uncertain, however, and might be considerably lower. Here we show that in mammalian cells, approximately 1% of methionine (Met) residues used in protein synthesis are aminoacylated to non-methionyl-tRNAs. Remarkably, Met-misacylation increases up to tenfold upon exposing cells to live or non-infectious viruses, toll-like receptor ligands or chemically induced oxidative stress. Met is misacylated to specific non-methionyl-tRNA families, and these Met-misacylated tRNAs are used in translation. Met-misacylation is blocked by an inhibitor of cellular oxidases, implicating reactive oxygen species (ROS) as the misacylation trigger. Among six amino acids tested, tRNA misacylation occurs exclusively with Met. As Met residues are known to protect proteins against ROS-mediated damage, we propose that Met-misacylation functions adaptively to increase Met incorporation into proteins to protect cells against oxidative stress. In demonstrating an unexpected conditional aspect of decoding mRNA, our findings illustrate the importance of considering alternative iterations of the genetic code.
[ 0.0085419537499547, 0.01870451308786869, -0.015019852668046951, 0.012163933366537094, -0.029142122715711594, -0.002536688232794404, 0.012222092598676682, -0.0033005280420184135, -0.017313752323389053, -0.02893509343266487, -0.01124620996415615, 0.010881590656936169, -0.0242423415184021, 0.010751847177743912, -0.02509324625134468, -0.009444944560527802, -0.017790934070944786, 0.01331560779362917, 0.01483394019305706, -0.021612443029880524, 0.00018831039778888226, -0.04303596913814545, 0.010029961355030537, -0.0014896048232913017, -0.008695924654603004, 0.006532884202897549, 0.011559410020709038, 0.00240263226442039, 0.016005512326955795, 0.001267930492758751, 0.02314492128789425, 0.004010519478470087, 0.04207921400666237, -0.01299439650028944, -0.002655814867466688, 0.01335611380636692, 0.0026555564254522324, 0.02799244225025177, 0.07672761380672455, -0.004524316638708115, 0.01658671535551548, -0.009000839665532112, 0.008784804493188858, -0.016853738576173782, -0.0050446754321455956, 0.007196664344519377, 0.0010788853978738189, 0.02586328610777855, -0.011120546609163284, 0.00702932383865118, -0.009881253354251385, -0.007083636708557606, -0.010608269833028316, 0.047275129705667496, -0.007196865044534206, -0.043508805334568024, 0.019662700593471527, -0.03182011470198631, -0.01858602836728096, 0.003918145317584276, 0.00267453258857131, -0.00513279577717185, 0.018584728240966797, -0.029454335570335388, -0.000003227265551686287, -0.06698031723499298, 0.016153043136000633, 0.014073068276047707, -0.003826563246548176, 0.025057625025510788, 0.016393762081861496, 0.011952189728617668, -0.026274310424923897, -0.03988657146692276, 0.04353103041648865, -0.004485221579670906, -0.017583832144737244, 0.013558575883507729, 0.028008176013827324, 0.009037843905389309, -0.01837889477610588, -0.0236586295068264, 0.009414169937372208, 0.003888086648657918, 0.004714038223028183, -0.008641734719276428, -0.011841226369142532, 0.04505370929837227, 0.000337088480591774, -0.0384540818631649, 0.013944044709205627, 0.012510612607002258, 0.02004508674144745, -0.022575698792934418, 0.026654325425624847, 0.054847970604896545, 0.010373993776738644, -0.004888452123850584, -0.013215802609920502, 0.026633240282535553, -0.021810203790664673, 0.02493847720324993, 0.02021481655538082, -0.006486097350716591, 0.0011098403483629227, 0.011988664045929909, -0.00688504334539175, 0.03496089577674866, 0.0018240425270050764, 0.007219237275421619, 0.02746332809329033, 0.01157959271222353, -0.01895357109606266, 0.027245227247476578, 0.0005551519570872188, -0.009068459272384644, -0.0019966016989201307, -0.02350347489118576, 0.009339720010757446, -0.024152878671884537, 0.03509335219860077, 0.014328068122267723, -0.00737776467576623, -0.03136017173528671, 0.005889399908483028, -0.013202463276684284, -0.003815842792391777, -0.00783919170498848, -0.00790181290358305, 0.023770881816744804, -0.006328585557639599, 0.019930651411414146, -0.03547694906592369, -0.025517772883176804, 0.0031867893412709236, 0.006676036398857832, 0.00954930204898119, 0.0002596280537545681, -0.0071207620203495026, 0.00030169589444994926, 0.015698399394750595, 0.007732197642326355, -0.0002229902020189911, 0.011896778829395771, 0.007127371616661549, 0.008955540135502815, 0.00582701712846756, 0.013140343129634857, 0.015628522261977196, -0.033581241965293884, -0.019931640475988388, 0.012211647816002369, -0.00671410420909524, -0.011623214930295944, -0.004867924842983484, -0.009270736947655678, 0.017887435853481293, -0.02695983275771141, -0.0036407914012670517, -0.013583608902990818, 0.007589041255414486, 0.0034781564027071, 0.016482045873999596, 0.00807498674839735, 0.010483919642865658, -0.0016032969579100609, -0.005644491408020258, -0.00435833353549242, -0.030231226235628128, 0.005524451844394207, -0.014178079552948475, 0.01625921204686165, 0.0025797272101044655, 0.001502804458141327, -0.005053223576396704, -0.006003269925713539, 0.013260308653116226, 0.007606053724884987, -0.024573631584644318, 0.06655509769916534, -0.0005789352580904961, 0.02094719186425209, 0.03627900779247284, 0.022036470472812653, 0.011409742757678032, -0.004504422657191753, 0.023961052298545837, -0.0031085005030035973, 0.004455283284187317, 0.020562905818223953, 0.00996382161974907, -0.01749344915151596, -0.021793512627482414, -0.02629811316728592, 0.0012515326961874962, 0.0036036523524671793, 0.01287518534809351, 0.014433885924518108, 0.008817728608846664, -0.007661689072847366, 0.0012159328907728195, 0.006774814799427986, 0.006635691970586777, -0.004820748697966337, 0.01379135251045227, 0.009506858885288239, 0.014560094103217125, 0.002530092839151621, -0.005826248787343502, -0.006347346119582653, 0.045236729085445404, -0.013845689594745636, -0.005704780109226704, -0.02059725672006607, -0.005112796556204557, -0.0009820213308557868, 0.009679395705461502, 0.010120785795152187, 0.0033197160810232162, -0.011017296463251114, 0.003944787196815014, -0.026421669870615005, 0.002589746844023466, -0.01856841892004013, 0.006435764487832785, -0.0025105916429311037, 0.0063729481771588326, 0.008265141397714615, -0.0005996834952384233, -0.00596415251493454, 0.000195343978703022, -0.05654468387365341, -0.01289227046072483, 0.00743831554427743, -0.01050715334713459, -0.006668819114565849, 0.010920331813395023, -0.009261248633265495, 0.025993792340159416, -0.014673815108835697, -0.0035118553787469864, 0.01768256351351738, 0.0064614396542310715, -0.030817190185189247, -0.025941062718629837, -0.021771935746073723, 0.0018586369697004557, -0.008233296684920788, -0.03990082070231438, -0.031156182289123535, 0.007955390959978104, -0.019383400678634644, -0.002565454225987196, 0.028430188074707985, 0.013574466109275818, 0.0017520277760922909, 0.020532961934804916, -0.005745830945670605, 0.027431415393948555, -0.0008609620854258537, 0.006053827702999115, 0.003894532099366188, -0.0047654565423727036, -0.015820112079381943, 0.000247815391048789, 0.0014335887972265482, 0.021060805767774582, -0.013689510524272919, -0.012640617787837982, -0.0045957318507134914, 0.002829859731718898, -0.009118501096963882, -0.001887952210381627, -0.08125729113817215, -0.008208748884499073, 0.0009713651379570365, -0.010735433548688889, 0.00288871256634593, -0.001789446105249226, -0.003164148423820734, -0.01954127848148346, -0.012949589639902115, 0.016238681972026825, -0.0028091012500226498, -0.012789059430360794, -0.012577816843986511, 0.026969967409968376, 0.005411991383880377, -0.011279433965682983, 0.005893338937312365, -0.010108714923262596, 0.007178888656198978, -0.03942779451608658, -0.004992881789803505, -0.008292123675346375, 0.0009340844117105007, 0.010664227418601513, -0.00630288477987051, 0.04359452426433563, 0.01353557500988245, -0.004341011866927147, -0.009660506621003151, 0.0019047106616199017, -0.026785334572196007, -0.010731441900134087, -0.0006491681560873985, -0.007788804825395346, 0.03428100049495697, 0.04380926117300987, -0.008123043924570084, 0.008548729121685028, -0.010315986350178719, 0.027971528470516205, -0.012362595647573471, 0.010761271230876446, -0.002337166341021657, -0.0025289421901106834, 0.015217396430671215, 0.02591506764292717, -0.014176158234477043, 0.013236693106591702, 0.017686039209365845, 0.009004748426377773, 0.022325532510876656, 0.001894927117973566, 0.038697123527526855, 0.02967502921819687, -0.009925561025738716, 0.017660940065979958, 0.022632157430052757, 0.04837489128112793, -0.016180668026208878, -0.009253332391381264, -0.021196860820055008, -0.0050969356670975685, -0.04364151880145073, 0.00019458867609500885, 0.014049177058041096, 0.01673399657011032, 0.023957306519150734, -0.03255165368318558, -0.015841424465179443, 0.006244140211492777, -0.011094723828136921, -0.01563299261033535, 0.005011239089071751, -0.004922126419842243, -0.043214112520217896, -0.019726587459445, -0.011687769554555416, -0.006522044539451599, -0.015522482804954052, -0.01700136624276638, -0.01584477350115776, -0.017475683242082596, 0.0007365045603364706, -0.008949754759669304, -0.032148417085409164, -0.008242931216955185, 0.004053470678627491, 0.012732250615954399, 0.012280146591365337, -0.015603246167302132, 0.03221690282225609, -0.025783486664295197, -0.003473061602562666, 0.008433563634753227, -0.015411857515573502, -0.025582462549209595, -0.011562823317945004, -0.017034124583005905, 0.006580581422895193, 0.010276684537529945, -0.017835939303040504, -0.00873989425599575, -0.003342048265039921, -0.0048633357509970665, -0.017784032970666885, 0.01366402581334114, -0.009010668843984604, 0.0150443185120821, 0.01395480427891016, -0.0021883314475417137, -0.013413958251476288, -0.0027244100347161293, -0.0052370959892869, 0.025324303656816483, 0.008758656680583954, 0.00509851798415184, -0.010366520844399929, 0.013139822520315647, 0.07178059220314026, 0.01496395468711853, -0.009349541738629341, -0.01975923776626587, -0.007842302322387695, -0.007605490740388632, 0.018899094313383102, 0.00679581705480814, 0.006056676618754864, -0.006292144767940044, 0.014516063965857029, 0.008411197923123837, 0.018641147762537003, 0.003784438129514456, -0.029359903186559677, -0.007253845222294331, -0.0036917792167514563, -0.022460812702775, 0.019076943397521973, 0.024471569806337357, 0.024557404220104218, -0.015867795795202255, -0.02760922908782959, -0.009249607101082802, -0.015728184953331947, 0.027089165523648262, 0.01809678226709366, -0.01500948891043663, -0.026608053594827652, 0.006029786542057991, 0.006170391570776701, -0.011195680126547813, -0.005499030463397503, 0.004833796061575413, 0.024170171469449997, 0.00047736940905451775, 0.0011254423297941685, 0.007023721933364868, -0.029946662485599518, -0.012298040091991425, 0.03568778932094574, -0.01038956455886364, 0.005485511384904385, 0.00512327253818512, 0.0058583710342645645, -0.037363506853580475, 0.007004783023148775, -0.006041561719030142, 0.011191890574991703, -0.0002887994050979614, -0.002355281263589859, -0.016564015299081802, 0.014150734059512615, 0.025209803134202957, -0.01005815714597702, -0.01761365681886673, 0.03996526822447777, -0.0027507527265697718, -0.012892386876046658, -0.04450911283493042, -0.008911793120205402, 0.019844207912683487, 0.05482187122106552, -0.0170457623898983, 0.024020854383707047, -0.018654663115739822, -0.019638463854789734, 0.01942330226302147, 0.005432740319520235, 0.022370461374521255, -0.002885648515075445, -0.003009988460689783, -0.0002913307398557663, -0.001475199474953115, -0.03553516045212746, -0.05084778368473053, -0.020834598690271378, -0.009966166689991951, 0.009167902171611786, -0.04827728495001793, 0.03358110040426254, 0.024457072839140892, -0.010183252394199371, -0.016244350001215935, 0.0069697462022304535, -0.03312196582555771, 0.005335710942745209, -0.07449579983949661, -0.01811269298195839, 0.006516812834888697, -0.007170221768319607, -0.012250342406332493, 0.00930759496986866, -0.013145113363862038, -0.007441378198564053, 0.04858286678791046, 0.00145534158218652, 0.02590712532401085, 0.014873652718961239, 0.013020035810768604, -0.016882654279470444, 0.011031684465706348, -0.016694389283657074, -0.029322616755962372, 0.010559964925050735, -0.024068977683782578, 0.020786328241229057, -0.029728472232818604, 0.012586165219545364, -0.037939026951789856, 0.012906912714242935, -0.00932847335934639, -0.08072763681411743, 0.012367551214993, 0.010428408160805702, 0.009998534806072712, -0.01521361991763115, 0.011126097291707993, -0.0056246984750032425, -0.01593206450343132, 0.008761761710047722, -0.016454413533210754, -0.013844132423400879, -0.007703323382884264, -0.022568006068468094, -0.006973957642912865, 0.02247924730181694, -0.00971897505223751, 0.016094805672764778, -0.0011416594497859478, -0.01427402999252081, -0.02246205508708954, -0.023775486275553703, -0.012025466188788414, -0.010810554027557373, -0.021045006811618805, -0.005719696171581745, -0.005705696530640125, -0.017446277663111687, 0.011849578469991684, 0.012777337804436684, 0.007268995512276888, -0.00936657190322876, 0.004523587413132191, -0.0034289914183318615, -0.04870608076453209, -0.00833144411444664, -0.012865127995610237, -0.005045719910413027, -0.012755824252963066, 0.007839052006602287, -0.01814890466630459, -0.010952982120215893, -0.0029906616546213627, -0.03754732757806778, -0.014626365154981613, 0.0003880285657942295, -0.0011868197470903397, 0.0031827609054744244, -0.015038342215120792, 0.006924247369170189, -0.02960449457168579, 0.010285456664860249, -0.02869441732764244, -0.0036988211795687675, 0.019807685166597366, -0.005871419794857502, 0.012237438932061195, -0.008077365346252918, 0.007390810176730156, 0.0064422450959682465, 0.008820965886116028, -0.01621255651116371, 0.007871141657233238, 0.0007657152600586414, 0.07137235254049301, -0.0069886171258986, 0.004623623564839363, -0.019972851499915123, -0.018567152321338654, -0.0015107414219528437, 0.006404385436326265, 0.01633734628558159, 0.00648809690028429, -0.010084462352097034, 0.008113072253763676, -0.003647960489615798, 0.022668249905109406, 0.013334967195987701, -0.00257872324436903, 0.033655330538749695, -0.03755355626344681, 0.021880613639950752, -0.024959590286016464, 0.009294858202338219, -0.05179274082183838, 0.01994221843779087, -0.005762090906500816, -0.0036917468532919884, -0.015949733555316925, -0.005565437022596598, 0.017586518079042435, 0.03087772987782955, -0.0025133511517196894, -0.01375254150480032, -0.01379372924566269, 0.007994483225047588, 0.00932154431939125, 0.048520516604185104, 0.011854428797960281, 0.009625962004065514, 0.012555291876196861, 0.007554708980023861, 0.014548810198903084, -0.03402649611234665, 0.029872845858335495, 0.006987414322793484, -0.008586779236793518, -0.018130235373973846, 0.0015114019624888897, 0.016171272844076157, 0.008466299623250961, 0.025372035801410675, -0.012854126282036304, -0.0008570384234189987, 0.026591707020998, 0.0039942143484950066, -0.012462092563509941, -0.014466254971921444, -0.005933735985308886, 0.0020097182132303715, -0.025070037692785263, 0.013537870720028877, 0.0005531655624508858, -0.0005757852923125029, -0.002800051588565111, 0.0011621250305324793, -0.01920733042061329, -0.016937414184212685, 0.029182659462094307, -0.01757231540977955, 0.009979801252484322, -0.013743752613663673, 0.03307588770985603, 0.020890595391392708, -0.010895432904362679, 0.012499437667429447, 0.00558872427791357, 0.0031365344766527414, 0.02767406404018402, 0.004966625943779945, -0.01455179788172245, -0.02083827368915081, 0.0103830024600029, -0.012352319434285164, -0.020311202853918076, 0.02657141536474228, -0.004088287241756916, -0.008024200797080994, -0.028150558471679688, 0.005305896047502756, -0.0014454934280365705, -0.008187554776668549, -0.003662558738142252, 0.008847054094076157, -0.008043697103857994, 0.007597761228680611, 0.003156662918627262, 0.0171511210501194, 0.008572242222726345, 0.035661958158016205, -0.005518975201994181, 0.011902133002877235, -0.006533880718052387, 0.016588542610406876, 0.024360328912734985, 0.006470617838203907, 0.007963699288666248, 0.0012444669846445322, -0.01877059042453766, -0.0043687960132956505, -0.003568094689399004, -0.013547991402447224, -0.0011151405051350594, -0.0005687535740435123, 0.01810876838862896, -0.009760627523064613, 0.0019401861354708672, -0.021997328847646713, -0.013644808903336525, 0.010184286162257195, 0.004153729882091284, 0.013577571138739586, -0.01450139470398426, -0.009884367696940899, -0.012321950867772102, -0.013668033294379711, -0.026788335293531418, 0.03270260989665985, -0.02520960010588169, -0.035474762320518494, -0.012668116018176079, 0.005918925628066063, 0.013565599918365479, -0.0013082940131425858, 0.01443721354007721, -0.007980378344655037, -0.004420769400894642, -0.0009960271418094635, 0.0032714675180613995, -0.008867708966135979, 0.0014407383278012276, -0.018560348078608513, 0.003236222080886364, -0.02083446830511093, 0.02216847985982895, -0.015726445242762566, -0.0017331092385575175, 0.017506452277302742, 0.007826568558812141, 0.000025092391297221184, 0.0051867226138710976, 0.047366365790367126, 0.001585611142218113, -0.013787724077701569, -0.008853361010551453, 0.009745471179485321, 0.020243478938937187, -0.006342302542179823, -0.010986903682351112, 0.021548740565776825, 0.015253709629178047, -0.0039011850021779537, -0.005668596364557743, -0.006474235560745001, 0.003209284506738186, 0.019713934510946274, 0.034121230244636536, 0.006071777082979679, -0.0018888121703639627, 0.03833749145269394, 0.0005185846239328384, 0.004012776538729668, 0.0020694639533758163, -0.008706879802048206, -0.01059214398264885, -0.01529457326978445, 0.007369305472820997, 0.010026538744568825, 0.0014919789973646402, -0.0011214414844289422, -0.006704944185912609, -0.008282794617116451, 0.00017541716806590557, 0.0006436160765588284, 0.0012188749387860298, -0.0015163059579208493, -0.01220161933451891, -0.005506272893399, 0.018114786595106125, 0.013323759660124779, 0.00020471005700528622, 0.010315623134374619, 0.01444099098443985, 0.008967619389295578, -0.03511844947934151, 0.012869380414485931, -0.017187906429171562, 0.026873033493757248, -0.020654063671827316, 0.013614525087177753, 0.02717679738998413, -0.013489664532244205, 0.00715554878115654, 0.0065484195947647095, 0.002716774120926857, -0.02554532140493393 ]
[ -0.057960864156484604, 0.2534714341163635, 0.23370473086833954, 0.15234218537807465, 0.2260764241218567, 0.13879938423633575, 0.4650081396102905, -0.7210501432418823, 0.21077856421470642, -0.5092198848724365, 0.3579231798648834, 0.9275188446044922, -0.26188817620277405, 0.18214727938175201, -0.37493523955345154, 0.5141671895980835, 0.3086794316768646, 0.17637313902378082, -0.10859934985637665, -0.5945626497268677, -0.23727841675281525, -0.09525790810585022, 0.7556077241897583, -0.29515236616134644, 0.10532326251268387, -0.10212378948926926, 0.3922654688358307, -0.09147155284881592, -0.3331459164619446, -0.017530065029859543, 0.09413967281579971, -0.10395266860723495, -0.22432005405426025, -0.18041646480560303, 0.1486862152814865, 0.2000548541545868, -0.13062438368797302, 0.34617671370506287, 0.13376109302043915, -0.3207516372203827, 0.21502649784088135, -0.08924330025911331, -0.28952932357788086, 0.4025828242301941, -0.6065764427185059, -0.26528969407081604, -1.1169120073318481, 0.9350472688674927, -0.3153929114341736, -0.08019677549600601, -0.26284077763557434, 0.17801211774349213, 0.4587414860725403, 0.3201237916946411, 0.013106484897434711, 0.3886374533176422, -0.34031131863594055, -0.35246315598487854, 0.3712519705295563, -0.19165799021720886, 0.02189500816166401, 0.026917675510048866, -0.545443058013916, 0.62465500831604, 0.04460391402244568, 0.3053443729877472, 0.2876946032047272, -0.9377442002296448, -0.6626991033554077, -0.0665012076497078, 0.15813136100769043, 0.16958056390285492, -0.14623437821865082, 0.179568812251091, -0.2822554409503937, -0.16597670316696167, -0.4528172016143799, 0.09719041734933853, 0.5926520228385925, -0.5447723865509033, 0.16767044365406036, 0.31772327423095703, -0.09825097769498825, -0.5103421807289124, 0.2183748483657837, -0.0336277075111866, -0.034521326422691345, 0.5942355990409851, -0.516567587852478, -0.11874520033597946, 0.11199819296598434, -0.5475618839263916, -0.7893378734588623, 0.7676101326942444, 0.3471197783946991, 0.0751638263463974, -0.0898858979344368, 0.12935064733028412, 0.0715208500623703, 0.3933761715888977, 0.033482953906059265, -0.43373098969459534, 0.3805074691772461, -0.1005229651927948, -0.18382598459720612, -0.621502161026001, -0.38750866055488586, -0.3233437240123749, -0.6353269815444946, 0.274138867855072, -0.306593120098114, 0.43425390124320984, 0.04787058383226395, -0.465974360704422, -0.27482694387435913, -0.0647207573056221, 0.30497047305107117, -0.2722887396812439, 0.23986463248729706, 0.10373421013355255, -0.4784002900123596, 1.0264456272125244, 0.052694112062454224, 0.2866292893886566, -0.06182452291250229, 0.10629314929246902, 0.29053187370300293, 0.4728343188762665, -0.42491936683654785, 0.15039032697677612, 0.2733575403690338, 1.052496314048767, -0.042062174528837204, 0.10007074475288391, -0.08649519830942154, -0.1452663391828537, 0.48410680890083313, -0.18638548254966736, 0.21637605130672455, -0.08120404183864594, -0.32762211561203003, -0.6575045585632324, -0.307245671749115, 0.268087238073349, 0.36828604340553284, -0.5552386045455933, 0.3556613624095917, -0.15510186553001404, -0.26550528407096863, 0.32934752106666565, -0.03736133128404617, -0.06376446038484573, -0.8008638620376587, -0.45092323422431946, 0.03315006196498871, 0.03927771374583244, 0.20256009697914124, 0.2276764065027237, -0.604541003704071, 0.2652011513710022, 0.0673791691660881, 0.1431894600391388, -0.8516052961349487, -0.522398829460144, 0.13967503607273102, -0.6884822845458984, 0.8034920692443848, 0.7520803809165955, -0.18206612765789032, 0.06076901778578758, -0.016431808471679688, -0.08288436383008957, 0.3243158459663391, -0.5602931976318359, -0.5196484923362732, 0.20909759402275085, 0.43312737345695496, 0.12065140157938004, -0.0774974524974823, -0.3694004714488983, -0.6960763335227966, 0.3147045075893402, 0.15170471370220184, -0.1551555097103119, 0.7815093398094177, -0.22819852828979492, 1.1873657703399658, -0.06701129674911499, -0.7820609211921692, -0.45531603693962097, -0.10416702926158905, -0.3299582004547119, 0.8990464210510254, -1.0236388444900513, 1.218861699104309, 0.27843591570854187, 0.04991361126303673, 1.5474419593811035, -0.3586851954460144, 0.040333643555641174, -0.4002678096294403, 0.6131948828697205, 0.15210123360157013, -0.727307140827179, -0.4517848789691925, -0.15009939670562744, 0.42602553963661194, -0.38757556676864624, -0.23477333784103394, 0.377676784992218, 0.5574154853820801, -0.537408173084259, -0.17233814299106598, 0.20422397553920746, -0.0785117968916893, -0.4387844204902649, 0.20547012984752655, 0.06209918484091759, 0.04352062568068504, -0.30805692076683044, 0.5324759483337402, -0.3995804190635681, 0.4436380863189697, 0.7848554253578186, -0.22458547353744507, 0.4016926884651184, 0.09518645703792572, 0.3978823721408844, 0.4379675090312958, 0.07633725553750992, -0.13993851840496063, -0.6427184343338013, 0.6199114322662354, -0.03268967941403389, -0.06302981078624725, -0.06244458258152008, 0.35897594690322876, 0.18499118089675903, 0.314389705657959, 0.16939234733581543, -0.40490150451660156, 0.3777409791946411, -0.2989034056663513, 0.11709979921579361, -0.2837117314338684, -0.4964885711669922, -0.2068360149860382, 0.3210361897945404, -0.6895114183425903, -0.04988319054245949, 0.1403229981660843, -0.1884409487247467, 0.3216048777103424, -0.5447023510932922, -0.22002053260803223, -0.23802365362644196, -0.202967569231987, -0.3375461995601654, -0.29205840826034546, -0.12485544383525848, -0.05029543116688728, -0.2629797160625458, 0.40264809131622314, -0.47583460807800293, -0.20098933577537537, -0.24224968254566193, -0.6606428623199463, -0.8838841915130615, 1.0579731464385986, 0.5224881172180176, 0.08424852043390274, 0.2316405475139618, -0.7732350826263428, -0.003940109629184008, -0.072178415954113, -0.11135023832321167, -0.033032987266778946, 0.17157742381095886, -0.47075414657592773, -0.06125166639685631, 0.39773276448249817, 0.39531728625297546, 0.7170324325561523, -0.6036500334739685, -0.6026195883750916, 0.01636466197669506, -0.04270041361451149, -0.7423136234283447, -0.13881580531597137, -0.14610034227371216, -0.6789084672927856, 0.5481941103935242, -0.24039700627326965, -0.8183221220970154, 0.12690608203411102, 0.38498473167419434, 0.24404607713222504, -0.061477258801460266, 0.5792614221572876, -0.1620989590883255, 0.3350544273853302, -0.24470774829387665, -0.3429732918739319, -0.08434316515922546, -0.09126752614974976, -0.10977159440517426, 0.1265987604856491, -0.03269089013338089, -5.788389205932617, -0.04901266098022461, -0.2401927411556244, -0.19366639852523804, 0.24506980180740356, -0.37844884395599365, 1.3025320768356323, 0.007076806854456663, 0.20540562272071838, -0.30578047037124634, -0.1598154455423355, -0.027836114168167114, 0.1649065464735031, 0.10323893278837204, 0.20143844187259674, -0.4735642969608307, 0.6645359992980957, -0.2693341076374054, 0.5455780625343323, 0.21336010098457336, 0.7415440082550049, -0.45148399472236633, 0.45394009351730347, -0.0667504072189331, 0.3495059311389923, -0.200691357254982, -1.132819652557373, -0.10258913785219193, -0.21572177112102509, -0.7607156038284302, -0.5156877040863037, -0.48867443203926086, -0.2018541693687439, -0.45100945234298706, 0.5335491895675659, 0.043150246143341064, 0.02511945366859436, 0.18393653631210327, 0.30883947014808655, -0.008006901480257511, 0.7565752863883972, 0.3053521513938904, 0.41286852955818176, -0.06702348589897156, 0.11934904754161835, 0.010294968262314796, -0.012721066363155842, 0.33962106704711914, 0.10699373483657837, 0.8682845234870911, -0.35048359632492065, 0.05736083164811134, 0.6625725030899048, 0.41389989852905273, 0.1424364596605301, -0.6779662370681763, 0.15737083554267883, 0.002352983457967639, -0.351388543844223, -0.006629588548094034, -0.47568440437316895, -0.5464662313461304, 0.03872225433588028, -1.0200351476669312, -0.19940321147441864, 0.19477440416812897, -0.45502349734306335, -0.41140660643577576, -0.07403291016817093, 0.2572322189807892, -0.47164249420166016, 0.1369461715221405, 0.053879398852586746, -0.2405940592288971, 0.7536987662315369, -0.15415672957897186, 0.27583298087120056, 0.065653495490551, -0.020689846947789192, -0.1513226479291916, -0.3340522348880768, -0.26731640100479126, 0.025758938863873482, -0.12031957507133484, 0.16243964433670044, -0.4724257290363312, -0.1784755289554596, 0.09540732949972153, -0.21079199016094208, 0.17021654546260834, 0.49067285656929016, -0.4744945764541626, 0.157283216714859, 0.28565922379493713, 0.2660355567932129, -0.6839964985847473, 0.6486160755157471, 0.5876200199127197, 0.8734545111656189, 0.33146432042121887, 0.2120347023010254, 0.29352641105651855, 0.07301989942789078, -0.7941164970397949, -0.27007654309272766, 0.1825866848230362, -0.7983124256134033, 0.25013092160224915, 0.47793295979499817, -0.28497713804244995, -0.48691636323928833, 0.11471801996231079, -0.2194652110338211, 0.28534963726997375, -0.06868430227041245, -0.04926560819149017, -0.1694723665714264, -0.4392338991165161, 0.24334080517292023, -0.2262820601463318, -0.3638926148414612, -0.1250564157962799, -0.593616247177124, 0.3450143039226532, 0.3235695958137512, -0.5109964609146118, 0.36226949095726013, 0.8863181471824646, -0.409133642911911, -0.20924632251262665, 0.09512273967266083, 0.6266670227050781, -0.3678026795387268, -0.4203908443450928, 0.12526395916938782, -0.34253525733947754, -0.32737940549850464, 0.5818865895271301, 0.15025553107261658, -0.3057877719402313, 0.34048596024513245, -0.34652841091156006, 0.22126933932304382, -0.11183810979127884, 0.24209946393966675, 0.09425048530101776, 0.3167891800403595, 0.1694387048482895, -0.1483451873064041, 0.08895035088062286, -0.09584732353687286, -0.2224428355693817, 0.38052162528038025, -0.41508162021636963, 0.19256754219532013, 0.18333220481872559, 0.2917780876159668, 0.28427940607070923, 0.23707684874534607, -0.6176680326461792, 0.09961050748825073, 0.5096442103385925, -0.5877700448036194, 0.1524614542722702, -0.23837094008922577, 0.030022043734788895, -0.06592947244644165, 0.18402045965194702, -0.5330266952514648, 0.21516509354114532, -0.16691645979881287, -0.17401722073554993, 0.16473430395126343, -0.39316171407699585, -0.02452876605093479, 0.1323683261871338, 0.11204324662685394, 0.09628162533044815, 0.05153536796569824, -0.15132778882980347, 0.14256714284420013, -0.25527727603912354, 0.2488812804222107, 0.47585567831993103, 0.19296547770500183, 0.028763167560100555, 0.021747831255197525, -0.1747475564479828, -0.1660895198583603, -0.4682789742946625, 0.12969978153705597, 0.24404893815517426, 0.28368863463401794, -0.7533111572265625, 0.11233467608690262, -0.1691407859325409, 0.548379123210907, 1.0285217761993408, 0.06393010169267654, -0.11537650227546692, 0.16331829130649567, 0.5620269775390625, -0.2152380645275116, 0.31093651056289673, 0.7728352546691895, 0.10842130333185196, -0.7158331274986267, 0.2682795524597168, 0.29763859510421753, -0.6478910446166992, -0.830760657787323, -0.486571729183197, -0.10373330861330032, 0.08311952650547028, -0.1978694349527359, -0.33085715770721436, 0.5351412296295166, 0.22381049394607544, -0.29541733860969543, 0.04499398544430733, 0.12541043758392334, -0.27665507793426514, -0.12837417423725128, 0.25581544637680054, -0.22671863436698914, -0.13529089093208313, 0.23951053619384766, -0.4235551357269287, 0.3832244575023651, -0.09103182703256607, 0.13710251450538635, -0.13199737668037415, 0.040257446467876434, 0.08915521204471588, -0.1814694106578827, -0.5330785512924194, -0.5472857356071472, 0.6514208316802979, -0.46368134021759033, -0.0016614467604085803, 0.2894445061683655, 0.934246838092804, 0.09420616179704666, 0.4995577335357666, -0.3661549687385559, 0.43314921855926514, 0.09971828758716583, -0.42169666290283203, -0.25185060501098633, 0.3232133388519287, 0.41392847895622253, 0.2542574405670166, -0.069068543612957, 0.3988298773765564, 0.8154382705688477, 0.592124342918396, 0.18058255314826965, -0.28820255398750305, 0.31270265579223633, 0.6668154001235962, -0.2727193236351013, -0.010308803990483284, -0.3190914988517761, -0.1370331346988678, 0.29845669865608215, 0.33165276050567627, -0.2705596089363098, -0.6941463947296143, 0.701697051525116, 0.0009437341941520572, -0.3496372699737549, -0.7188356518745422, 0.4880160391330719, 0.2139563411474228, -0.11843996495008469, -0.023996688425540924, -0.28233054280281067, 0.5916397571563721, 0.25804805755615234, -0.13726969063282013, -0.14433740079402924, -0.36653977632522583, 0.5751054286956787, -0.8440254926681519, 0.023494621738791466, -0.47761455178260803, 0.24848544597625732, -0.32807597517967224, -0.32121604681015015, -0.1066412702202797, -0.41465017199516296, 0.08083483576774597, -0.7655370831489563, 0.02548999711871147, -0.14244653284549713, 0.2198609709739685, 0.36969298124313354, 0.8091597557067871, -0.00511622941121459, -0.2205425351858139, -0.332660049200058, 0.07321453094482422, 0.9992785453796387, -0.7935513854026794, 0.05505506694316864, 0.1488960236310959, 0.14191840589046478, 0.3244558572769165, -0.40800172090530396, 0.30261942744255066, -0.13177403807640076, 0.07584668695926666, 0.5170077681541443, 0.07463200390338898, -0.01815960370004177, -0.5076042413711548, -0.034708231687545776, -0.01841961406171322, 0.12091647833585739, 0.25792166590690613, -0.16670802235603333, 0.10406696796417236, 0.19737552106380463, -0.28121495246887207, -0.21070720255374908, 0.44540971517562866, 0.13633544743061066, 0.05258052796125412, -0.17514367401599884, 0.6569417119026184, 0.35123410820961, 0.41062524914741516, -0.27177512645721436, 0.39782264828681946, 0.0602596215903759, -0.14158731698989868, 0.02837047539651394, -0.3424646258354187, -0.13670992851257324, 0.31914329528808594, 0.6504833698272705, 0.19225925207138062, -0.5906839370727539, 0.18779243528842926, 0.49652042984962463, -0.03278091177344322, 0.531448483467102, 0.04808377847075462, -0.36138731241226196, 0.6386780738830566, 0.4907228946685791, -0.56753009557724, -0.0910010039806366, 0.34459736943244934, -0.5069458484649658, -0.23467187583446503, 0.8257036805152893, -0.2916635572910309, -0.47035160660743713, -0.05003403127193451, -0.5373033285140991, 0.3530381917953491, -0.1655721366405487, 0.12514568865299225, -0.16604165732860565, -0.09903562813997269, 0.6785645484924316, 0.11630639433860779, 0.46286019682884216, -0.16466566920280457, 0.3340102434158325, 0.3700553774833679, -0.46081072092056274, 0.3758029043674469, 0.004190061241388321, -0.6803919672966003, -0.03234435245394707, -0.2652958035469055, -0.31831443309783936, -0.1855161339044571, -0.3662812411785126, 0.15570245683193207, -0.10752186179161072, -0.32102176547050476, -0.6923501491546631, -0.03816571086645126, -0.11860249191522598, -0.2907974421977997, -0.12914645671844482, -0.28105628490448, 0.8257298469543457, -0.7877904176712036, -0.5012715458869934, 0.07045182585716248, -0.4406636357307434, -0.33641868829727173, -0.10422180593013763, 0.45513007044792175, 0.32557252049446106, 0.6406986117362976, 0.034196797758340836, 0.27831605076789856, 0.2048717737197876, 0.5930179357528687, -0.42485710978507996, 0.5770125985145569, -0.17882142961025238, -0.201909139752388, -0.6177759766578674, -0.5380550026893616, 1.0205861330032349, 0.6587329506874084, 0.037909891456365585, -0.09225773066282272, 0.22690846025943756, -0.06918934732675552, 0.090303935110569, -0.5841771364212036, 0.4240609407424927, 0.023184387013316154, 0.132918581366539, -0.6048858761787415, 0.3091343939304352, 0.08259276300668716, -0.4647325277328491, -0.31870320439338684, 0.6186679005622864, 0.30747535824775696, -0.37980595231056213, 0.08024728298187256, -0.15281926095485687, -0.025797151029109955, -0.06966892629861832, 0.6563074588775635, -0.17912474274635315, 0.1391162872314453, -0.17374716699123383, 0.166608065366745, 0.22238081693649292, -0.4608951807022095, -0.27086201310157776, 0.0327177569270134, -0.37405604124069214, 0.5164085030555725, 0.11065176874399185, 0.19015951454639435, -0.0904463455080986, -0.5440590381622314, -0.32288020849227905, 0.1620045155286789, -0.006813076790422201, 0.04495507851243019, -0.3529834747314453, 0.04987668991088867, -0.3466144800186157, -0.4458494186401367, -0.046499285846948624, -0.6657365560531616, 0.1530776023864746, 0.46584340929985046 ]
The sirtuins are a phylogenetically conserved family of NAD(+) -dependent protein deacetylases that consume one molecule of NAD(+) for every deacetylated lysine side chain. Their requirement for NAD(+) potentially makes them prone to regulation by fluctuations in NAD(+) or biosynthesis intermediates, thus linking them to cellular metabolism. The Sir2 protein from Saccharomyces cerevisiae is the founding sirtuin family member and has been well characterized as a histone deacetylase that functions in transcriptional silencing of heterochromatin domains and as a pro-longevity factor for replicative life span (RLS), defined as the number of times a mother cell divides (buds) before senescing. Deleting SIR2 shortens RLS, while increased gene dosage causes extension. Furthermore, Sir2 has been implicated in mediating the beneficial effects of caloric restriction (CR) on life span, not only in yeast, but also in higher eukaryotes. While this paradigm has had its share of disagreements and debate, it has also helped rapidly drive the aging research field forward. S. cerevisiae has four additional sirtuins, Hst1, Hst2, Hst3, and Hst4. This review discusses the function of Sir2 and the Hst homologs in replicative aging and chronological aging, and also addresses how the sirtuins are regulated in response to environmental stresses such as CR.
[ 0.014977164566516876, -0.0006442367448471487, -0.00006271642632782459, 0.017908047884702682, 0.01350853219628334, -0.02686958760023117, 0.009674523025751114, 0.022092197090387344, -0.01159081794321537, 0.005289401859045029, -0.011241193860769272, -0.003275932278484106, -0.028447140008211136, -0.002977413823828101, 0.03195418789982796, 0.01256461814045906, -0.010388274677097797, -0.02166205272078514, 0.005071754101663828, 0.0051797921769320965, 0.002538276370614767, -0.00884267408400774, 0.008406026288866997, 0.003237005788832903, 0.015600317157804966, 0.00906211044639349, 0.02196309342980385, 0.011597743257880211, -0.01642432063817978, -0.0009885840117931366, 0.008281438611447811, -0.005614715628325939, 0.009104055352509022, 0.012403048574924469, 0.001243415754288435, 0.016861094161868095, -0.007310644723474979, 0.01803208701312542, 0.04141499102115631, -0.005672997795045376, -0.0010165827115997672, -0.009256617166101933, 0.0012777650263160467, 0.007505168206989765, -0.00699709402397275, 0.008666086941957474, 0.002837360603734851, -0.005011461675167084, -0.00044679921120405197, 0.000010129297152161598, -0.008984116837382317, -0.00628515612334013, -0.0034375530667603016, 0.013907041400671005, -0.005220065359026194, -0.007178380154073238, 0.015928108245134354, -0.016625218093395233, -0.05635197460651398, 0.01209279801696539, -0.0038621597923338413, 0.009437592700123787, 0.013281451538205147, 0.0070024654269218445, 0.014197712764143944, -0.06685096025466919, -0.008583101443946362, -0.005274648778140545, -0.003493016818538308, 0.009494614787399769, 0.021503416821360588, 0.0082949073985219, -0.025564350187778473, 0.0014366048853844404, -0.004240257665514946, -0.02351965755224228, -0.010939570143818855, 0.0037017494905740023, 0.01031244732439518, -0.005943886004388332, -0.017197873443365097, -0.005287576466798782, -0.008327306248247623, -0.008302507922053337, 0.017735909670591354, 0.0028673510532826185, -0.019716182723641396, -0.009723378345370293, 0.017682909965515137, -0.022132713347673416, 0.005500385537743568, 0.006207980215549469, 0.022262362763285637, 0.0015526387142017484, 0.011328356340527534, -0.003903007134795189, -0.016902344301342964, -0.006493459455668926, 0.019543977454304695, 0.0021989685483276844, -0.02564142271876335, -0.007836557924747467, 0.006359847262501717, 0.03582683205604553, -0.004647589288651943, 0.009992354549467564, 0.007443162612617016, 0.012134071439504623, -0.014777090400457382, 0.013504287227988243, -0.0004367345245555043, -0.00914650596678257, 0.01636131852865219, 0.016597174108028412, 0.015591086819767952, 0.023697644472122192, -0.012980485334992409, -0.016334805637598038, 0.015542772598564625, -0.025812828913331032, -0.011183574795722961, 0.0024333775509148836, 0.0006417681579478085, 0.009048174135386944, 0.009640336968004704, 0.009946199133992195, 0.007887902669608593, 0.010532397776842117, 0.01636783964931965, 0.008801297284662724, -0.007467931602150202, 0.00879228487610817, 0.006195723079144955, -0.018174858763813972, -0.005141626112163067, -0.004980842117220163, -0.009295717813074589, 0.021237071603536606, -0.008268775418400764, -0.021153919398784637, 0.011698155663907528, 0.007891564629971981, 0.014197703450918198, 0.00637245737016201, 0.014721338637173176, 0.00837252289056778, -0.014715579338371754, -0.010789066553115845, 0.009990492835640907, -0.010278304107487202, -0.01199689507484436, -0.017330005764961243, -0.008478889241814613, -0.015220515429973602, 0.017125766724348068, 0.006449943874031305, 0.001597428461536765, -0.039002809673547745, -0.0011610398069024086, 0.0019045415101572871, -0.030650613829493523, -0.020595379173755646, -0.009894861839711666, 0.007206866983324289, 0.00913650169968605, -0.007608089596033096, -0.009140781126916409, -0.00902482308447361, 0.025092201307415962, 0.011021401733160019, -0.005735444836318493, -0.0023628429044038057, 0.0383702851831913, 0.014691343531012535, -0.01089470088481903, -0.00019334745593369007, -0.009338312782347202, 0.008790981955826283, -0.014217300340533257, 0.06666381657123566, -0.0075073144398629665, 0.029010819271206856, 0.015262621454894543, -0.011723676696419716, 0.005485685542225838, -0.012954629957675934, 0.018649950623512268, -0.008632441982626915, -0.00506569491699338, 0.023665577173233032, -0.023576848208904266, -0.005673372186720371, -0.007057595532387495, 0.01317074429243803, -0.002093406394124031, 0.0017082078848034143, 0.020301539450883865, 0.007717610336840153, -0.010653011500835419, 0.010855946689844131, 0.02090766653418541, 0.013693388551473618, 0.018374841660261154, 0.021214190870523453, 0.021052813157439232, 0.008754420094192028, 0.009971913881599903, -0.00007164035923779011, -0.005339535418897867, 0.007779426872730255, 0.009330453351140022, -0.05425683781504631, -0.008610938675701618, -0.02473066933453083, -0.024564901366829872, 0.014572540298104286, -0.013243523426353931, 0.002499721944332123, 0.005797249730676413, -0.011005662381649017, -0.008088173344731331, -0.009640701115131378, 0.008769171312451363, -0.0061221495270729065, -0.020542282611131668, 0.022737901657819748, -0.001667955657467246, 0.0118430620059371, -0.02225313149392605, -0.015057322569191456, -0.0070695048198103905, -0.013092698529362679, -0.01630353555083275, 0.0030151107348501682, 0.003890646854415536, -0.007626574952155352, 0.009207818657159805, 0.0026864975225180387, 0.010477658361196518, -0.0042192162945866585, -0.003141692141070962, -0.01733173429965973, 0.04428477585315704, -0.010575424879789352, 0.011176771484315395, -0.006302191410213709, -0.024927683174610138, -0.021453242748975754, -0.002973231952637434, -0.016100389882922173, 0.004124789498746395, -0.003851125482469797, -0.01808929070830345, -0.015984900295734406, 0.012766944244503975, 0.009864045307040215, 0.026175744831562042, -0.022276636213064194, 0.023709431290626526, 0.0031835385598242283, 0.007263876497745514, 0.007594861090183258, -0.007084129378199577, 0.03235884755849838, -0.0037478646263480186, 0.013448208570480347, -0.031260814517736435, -0.0210026353597641, -0.006048358976840973, 0.01580810733139515, 0.010052984580397606, -0.011115459725260735, -0.0011959315743297338, -0.0814879909157753, 0.001357603003270924, 0.003575658891350031, 0.005632386077195406, 0.0061206454411149025, 0.014028513804078102, -0.015966810286045074, -0.0021249456331133842, -0.0014885587152093649, 0.03527889773249626, 0.005899457260966301, 0.016026537865400314, -0.015263590030372143, 0.0037091095000505447, -0.005305152386426926, -0.005949381738901138, 0.013326771557331085, 0.007210983894765377, 0.00556404422968626, -0.02175479382276535, -0.019215896725654602, 0.020865261554718018, 0.03180370107293129, -0.0027628177776932716, -0.014579148963093758, 0.0028152265585958958, 0.006736406125128269, -0.016431480646133423, -0.00023701880127191544, 0.001408809213899076, 0.0046905516646802425, -0.015606259927153587, 0.0056737931445240974, -0.00502735935151577, 0.022801393643021584, 0.010281393304467201, 0.003317491617053747, -0.03834785521030426, 0.005215373821556568, 0.003902998985722661, -0.01617177575826645, 0.02189861238002777, 0.009625138714909554, -0.007522499188780785, 0.018808679655194283, 0.02130495011806488, 0.016109665855765343, 0.01724008470773697, 0.019058510661125183, 0.0005387486889958382, 0.020734794437885284, -0.0013988818973302841, 0.018647465854883194, 0.019360292702913284, -0.012159360572695732, 0.0012699412181973457, 0.02531399019062519, 0.013623940758407116, -0.00877171941101551, -0.005535339470952749, -0.018466532230377197, -0.012632468715310097, -0.008934378623962402, 0.015303296037018299, 0.030718624591827393, 0.005715979728847742, 0.0039561595767736435, 0.00570446765050292, -0.00690067233517766, -0.0016488432884216309, -0.0005432094912976027, -0.03653711825609207, -0.007569054141640663, -0.007865671068429947, 0.011262455955147743, -0.012175328098237514, -0.013441169634461403, 0.0009761027758941054, -0.0044722226448357105, -0.03467763215303421, 0.02378913201391697, 0.004888421855866909, 0.009397527202963829, 0.013894758187234402, -0.01982555165886879, -0.023304838687181473, 0.005726870149374008, 0.00569209735840559, 0.0011605073232203722, -0.015552761033177376, 0.05804314464330673, -0.013533428311347961, 0.0009355260990560055, 0.01316917035728693, 0.003391415346413851, -0.028629440814256668, 0.01271570473909378, -0.004228107165545225, 0.002313668839633465, 0.005942482501268387, -0.03227566182613373, 0.005351393949240446, 0.010731382295489311, -0.00974753126502037, -0.002813190221786499, 0.018817327916622162, -0.005563778802752495, 0.008115950971841812, 0.004091326612979174, -0.0009960499592125416, -0.010368376038968563, 0.007989280857145786, -0.005405641160905361, 0.03302837535738945, 0.012043303810060024, 0.005921733565628529, -0.02838473953306675, -0.0062417094595730305, 0.07282514870166779, 0.01774130016565323, -0.006394656840711832, 0.0018917673733085394, 0.013938961550593376, -0.011701419949531555, 0.0184341948479414, 0.01719583198428154, -0.021807849407196045, -0.0021828217431902885, 0.011528782546520233, 0.020763318985700607, -0.0013022110797464848, 0.019205410033464432, -0.01792045496404171, 0.0019349936628714204, 0.007672467734664679, -0.014742447063326836, 0.015524260699748993, -0.0008869599550962448, 0.02615952491760254, -0.017798354849219322, 0.009179830551147461, 0.0021009594202041626, -0.0018154527060687542, -0.005260422360152006, -0.002220939379185438, -0.008806093595921993, -0.013762966729700565, 0.008977275341749191, 0.014910351485013962, 0.014420888386666775, -0.014694184996187687, -0.010397769510746002, 0.030915051698684692, 0.015700634568929672, -0.0018057944253087044, -0.026427768170833588, -0.007820049300789833, -0.008570529520511627, 0.01599898748099804, -0.012811432592570782, 0.0003532012924551964, 0.0068452670238912106, 0.009346519596874714, 0.02194375731050968, 0.013035192154347897, -0.009740290232002735, 0.004206154029816389, -0.005256957374513149, -0.0003642213996499777, 0.0002417747164145112, 0.0050573805347085, -0.009581340476870537, 0.01019851304590702, -0.016516048461198807, 0.020928939804434776, -0.004447113256901503, -0.012799035757780075, -0.02854180708527565, 0.016773978248238564, -0.022487187758088112, 0.005449820775538683, 0.005784783512353897, 0.01826792024075985, -0.031991466879844666, 0.02049512416124344, 0.005556550808250904, -0.024113839492201805, 0.013362107798457146, 0.003265657927840948, -0.0003126275260001421, -0.003179083112627268, 0.021541301161050797, -0.03225598856806755, 0.0043713925406336784, -0.007533479016274214, 0.00785790290683508, 0.02852112241089344, 0.013239116407930851, 0.006847649347037077, 0.006065962836146355, 0.01672070473432541, -0.010560017079114914, 0.009127505123615265, -0.015538079664111137, -0.007847562432289124, -0.07471688091754913, 0.002110934816300869, -0.0031730374321341515, -0.003934524487704039, 0.019669856876134872, 0.03016679175198078, -0.003667204175144434, 0.007702385075390339, -0.00022847414948046207, -0.006757376715540886, 0.007292671594768763, 0.004330553580075502, 0.001471267081797123, 0.01639782451093197, 0.009090399369597435, 0.015236574225127697, -0.02275070734322071, 0.013365364633500576, -0.008280603215098381, -0.02753593772649765, -0.04482690244913101, -0.007463314104825258, -0.030782321467995644, 0.011055678129196167, -0.009267029352486134, -0.08153171837329865, 0.004949548747390509, 0.008164246566593647, -0.004223773255944252, 0.004782629199326038, -0.012566003948450089, 0.001815060619264841, 0.008068921975791454, -0.037375304847955704, -0.015118058770895004, 0.012165647931396961, -0.008307145908474922, -0.0005196528509259224, -0.019568292424082756, -0.0009349682368338108, -0.014958671294152737, 0.0033434205688536167, 0.01118512637913227, 0.006679687649011612, -0.010938618332147598, -0.022821974009275436, 0.022264983505010605, -0.012387694790959358, -0.017410514876246452, -0.00654253177344799, 0.011961061507463455, -0.03162596374750137, 0.015304546803236008, 0.005508128087967634, 0.009741219691932201, -0.00373279582709074, 0.003970828838646412, -0.0023330780677497387, -0.014256027527153492, 0.006140111014246941, -0.019760511815547943, 0.022441256791353226, -0.012000341899693012, 0.0022092503495514393, -0.004356667399406433, -0.011668665334582329, -0.005286840721964836, -0.006289084441959858, 0.014375463128089905, 0.02159489132463932, -0.03175166994333267, 0.009146453812718391, -0.01260843314230442, -0.00824778527021408, -0.007671916391700506, 0.013758901506662369, -0.0040959385223686695, 0.019932370632886887, 0.014610962942242622, -0.002983748447149992, 0.01042630523443222, -0.0004915266181342304, 0.018869074061512947, 0.00397542305290699, 0.024743856862187386, -0.0035003109369426966, -0.015895705670118332, -0.005670567508786917, 0.07179424166679382, -0.00013685435988008976, 0.0034485505893826485, -0.0065047862008214, 0.0015063784085214138, 0.009411634877324104, -0.01039799302816391, -0.01808292791247368, 0.035243771970272064, -0.005733389873057604, -0.0013476908206939697, -0.003163886722177267, 0.018225068226456642, 0.01593596674501896, -0.0185004323720932, -0.021982409060001373, -0.008593063801527023, 0.02073228918015957, -0.01947098784148693, 0.029519397765398026, 0.0019876165315508842, 0.027834974229335785, -0.013279484584927559, -0.014770773239433765, 0.016251452267169952, -0.01647329330444336, 0.017570553347468376, 0.029790937900543213, -0.005691205617040396, 0.021048251539468765, -0.006970166228711605, -0.03800448030233383, 0.006244320422410965, 0.0024972460232675076, 0.022349802777171135, 0.013949730433523655, 0.00670619448646903, 0.007808234076946974, -0.022563617676496506, -0.018211396411061287, 0.02689397893846035, -0.022082747891545296, 0.0018693343736231327, -0.024960018694400787, 0.027438901364803314, 0.008582118898630142, -0.013532660901546478, -0.030305633321404457, -0.00695550162345171, 0.004926079884171486, 0.00920549314469099, 0.004788325168192387, -0.007100800052285194, -0.0009615560993552208, -0.006330977194011211, -0.017116811126470566, -0.018455635756254196, 0.01157352514564991, -0.013620899058878422, 0.00020178873091936111, 0.013053514063358307, 0.004282577428966761, -0.010356128215789795, -0.018840983510017395, 0.023445315659046173, -0.010436076670885086, 0.0010745557956397533, -0.01780642941594124, -0.013427859172224998, 0.021991517394781113, -0.0024939272552728653, 0.020721642300486565, 0.003749965224415064, 0.060208722949028015, 0.0012070058146491647, 0.017972281202673912, 0.01639055833220482, -0.008722043596208096, 0.03489106893539429, 0.0021061475854367018, -0.01159549318253994, -0.014894992113113403, -0.00923235435038805, -0.006661656312644482, -0.0378841906785965, -0.010914883576333523, -0.004124192520976067, 0.011286286637187004, 0.0038075707852840424, 0.0120454803109169, -0.008612086996436119, 0.011637642048299313, 0.017779357731342316, 0.006818268448114395, 0.01140766404569149, 0.03392534330487251, 0.018452191725373268, 0.008176087401807308, -0.028905358165502548, 0.0060002245008945465, 0.02297876961529255, -0.004426507279276848, 0.00817705038934946, 0.003156957682222128, -0.02920711226761341, -0.0049732755869627, 0.016876302659511566, 0.013072235509753227, 0.010684779845178127, -0.034014247357845306, 0.023682836443185806, 0.00761379674077034, -0.023035889491438866, 0.001312228967435658, -0.008021737448871136, 0.009400447830557823, -0.0237804614007473, -0.024261942133307457, -0.010502759367227554, -0.015546584501862526, 0.0142454719170928, -0.0022623699624091387, 0.011334612965583801, 0.020617211237549782, -0.024829834699630737, -0.023572688922286034, -0.010894500650465488, -0.005972548387944698, 0.02314787358045578, -0.006834998726844788, 0.00859218928962946, -0.0008749845437705517, 0.002998718526214361, -0.027566969394683838, 0.005297322291880846, 0.02035188302397728, -0.0032277933787554502, -0.00448303297162056, -0.0011271003168076277, -0.026777740567922592, 0.0032309778034687042, -0.01411955151706934, -0.0056273601949214935, 0.02261529117822647, 0.008084353059530258, 0.0034069716930389404, 0.009109166450798512, -0.004112506750971079, 0.007204368244856596, 0.0014583019074052572, 0.0022701239213347435, 0.006126246880739927, 0.003411755198612809, -0.01053941622376442, -0.03761981427669525, 0.01945561356842518, 0.021960876882076263, 0.01055876538157463, 0.015602302737534046, -0.006132770329713821, 0.02165016531944275, 0.00849701277911663, 0.0034663453698158264, 0.00541134737432003, 0.031788162887096405, -0.00838164146989584, 0.0015638694167137146, 0.017537303268909454, 0.005715672392398119, 0.040944457054138184, -0.010060600005090237, 0.002884606132283807, 0.017554597929120064, -0.0017933454364538193, 0.002399551449343562, -0.005137661471962929, -0.009571170434355736, -0.012173160910606384, 0.00509626604616642, 0.022113949060440063, -0.021972838789224625, 0.01127663068473339, 0.007051499560475349, -0.0091780386865139, 0.0122750923037529, -0.0005830612499266863, -0.0061736078932881355, 0.0047468943521380424, -0.022822055965662003, 0.004922894760966301, -0.002863390604034066, -0.012186024338006973, -0.0006442973390221596, 0.013186506927013397, 0.0022916789166629314, 0.010306032374501228, -0.0041067530401051044, -0.015938421711325645, 0.02602902054786682, -0.00466982601210475, -0.013200590386986732, 0.019116617739200592 ]
[ -0.3953622281551361, -0.21131925284862518, 0.43111923336982727, -0.16048070788383484, -0.2450014352798462, -0.017507027834653854, -0.13440316915512085, -0.13341224193572998, -0.09074347466230392, -0.5351957678794861, -0.03942533954977989, 0.1756218522787094, -0.4325597286224365, 0.8496462106704712, 0.09838955104351044, 0.8131665587425232, -0.02063588611781597, 0.30762746930122375, -0.3579796552658081, -0.11896583437919617, -0.22774817049503326, -0.36491307616233826, 0.8499795198440552, -0.25396299362182617, 0.5280200839042664, 0.13423490524291992, 0.45187002420425415, 0.1898856908082962, 0.7699313759803772, -0.19007347524166107, 0.11976642906665802, 0.03984052687883377, 0.029326273128390312, -0.2981315851211548, -0.5691909790039062, -0.1682017743587494, -0.46731317043304443, -0.11299536377191544, 0.256614089012146, -0.10358057916164398, -0.4181455075740814, -0.2752635180950165, -0.20458270609378815, 0.5655693411827087, -0.2549954950809479, 0.10251962393522263, -1.3326473236083984, 0.5010418891906738, -0.6348074674606323, -0.04857818782329559, -0.38206714391708374, 0.10054787993431091, 0.4639209806919098, -0.32318082451820374, 0.34158051013946533, 0.256417453289032, -0.8957796692848206, 0.10144011676311493, 0.22240135073661804, -1.188865065574646, -0.12527351081371307, 0.08686951547861099, 0.09089528024196625, 0.27027076482772827, 0.08151263743638992, 0.6607494950294495, 0.16439348459243774, -0.7759782671928406, -0.8405161499977112, 0.08816204220056534, -0.20152132213115692, -0.5505115389823914, -0.37287622690200806, 1.0065995454788208, 0.0680026262998581, -0.3423082232475281, -0.45448654890060425, -0.5766780376434326, 0.03898865729570389, -0.18670715391635895, 0.06325076520442963, 0.04177531972527504, 0.23306338489055634, 0.01719803549349308, 0.27262231707572937, 0.23074957728385925, -0.04399769380688667, 0.3263609707355499, -0.6997602581977844, 0.48270973563194275, -0.004122711718082428, 0.1937079131603241, 0.34313446283340454, -0.02742028422653675, 0.35068655014038086, -0.058567922562360764, 0.06073502078652382, 0.03906918317079544, -0.2850346565246582, 0.6266579031944275, -0.36250796914100647, 0.32355475425720215, -0.06414133310317993, -1.0719510316848755, -0.6557011008262634, -0.1583845615386963, 0.024363165721297264, -0.31576302647590637, -0.26615819334983826, -0.052115727216005325, -0.641734778881073, -0.13127805292606354, -0.10261161625385284, 0.2070312798023224, 0.45671477913856506, 0.12204165011644363, 0.48594143986701965, -0.6015090942382812, 0.14688250422477722, -0.35327908396720886, -0.2943958044052124, 1.0384994745254517, 0.12550893425941467, 0.6906625032424927, 0.14384052157402039, -0.3156742751598358, -0.3196371793746948, -0.38347914814949036, -0.254264771938324, 0.6638439297676086, 0.7812188863754272, 0.7892252206802368, -0.05179520323872566, -0.19785583019256592, -0.29447126388549805, -0.05668865889310837, -0.18966232240200043, 0.1952061951160431, 0.2707727253437042, -0.2330988496541977, -0.7063270211219788, 0.11910156160593033, -0.2507603168487549, -0.36437252163887024, 0.08038122206926346, -0.6075452566146851, -0.14348119497299194, 0.10060518980026245, 0.041212696582078934, -0.126102015376091, 0.07475433498620987, -0.43297117948532104, -1.0670654773712158, 0.023950425907969475, 0.07834875583648682, 0.20315426588058472, 0.32103341817855835, -0.2928783893585205, 0.4080045819282532, 0.4824869930744171, 0.036458443850278854, -0.27113187313079834, -0.609556257724762, -0.3505639433860779, 0.2740648686885834, 0.011509559117257595, 0.3860275447368622, 0.6566697955131531, -0.11677589267492294, -0.15610459446907043, -0.3986770510673523, -0.5041200518608093, 0.309802383184433, -0.7893851399421692, -0.16606895625591278, 0.031241314485669136, 0.5508286952972412, -0.46315518021583557, 0.3659459352493286, -0.08854896575212479, -0.7068477272987366, -0.3966074287891388, -0.011595554649829865, -0.22506563365459442, 0.7014407515525818, 0.19594928622245789, 0.4794844686985016, 0.015516196377575397, 0.2771225869655609, -0.262478232383728, -0.47656822204589844, -0.16104863584041595, 0.6059224009513855, -0.05648231506347656, 1.0675801038742065, 0.09805352240800858, -0.3089274764060974, 1.2190022468566895, 0.36303892731666565, 0.21350432932376862, -0.7109888792037964, 0.14547677338123322, -0.03371232748031616, -0.6644322872161865, -0.6687157154083252, -0.08065527677536011, -0.501038134098053, -0.1629774570465088, 0.27436208724975586, 0.08907944709062576, 0.19577093422412872, -0.5416947603225708, -0.053572073578834534, -0.2588149607181549, 0.4883793294429779, -1.0255520343780518, 0.4557042419910431, -0.026479551568627357, -0.6163452863693237, -0.02686757780611515, 0.7691587805747986, -0.5285064578056335, 0.8776738047599792, 1.0343014001846313, -0.5320370197296143, 0.38404443860054016, 0.38628751039505005, 0.4108430743217468, 0.6700982451438904, 0.2384047657251358, 0.7551767230033875, -0.6796614527702332, 0.22848963737487793, -0.3391442596912384, 0.3204486668109894, 0.05650081858038902, -0.040885549038648605, 0.0874052345752716, -0.22609694302082062, -0.17691069841384888, 0.027389636263251305, 0.8650267124176025, -0.8281853795051575, -0.5319067239761353, 0.028933443129062653, -0.5246400237083435, -0.1850365847349167, 0.414827823638916, -0.5282493829727173, -0.15764205157756805, -0.12822198867797852, 0.49011045694351196, 0.23767885565757751, -0.29374465346336365, 0.28525447845458984, 0.16244332492351532, -0.03919754922389984, -0.07083076983690262, 0.2706427276134491, -0.47729289531707764, -0.48767489194869995, -0.08289551734924316, -0.3174816071987152, 0.1727941930294037, 0.2939339280128479, -0.43698084354400635, -0.44657281041145325, -0.17905353009700775, 1.5720736980438232, 0.8215367197990417, 1.196593999862671, -0.07536973059177399, -1.0276188850402832, -0.5132320523262024, 0.05612344667315483, -0.8652732968330383, 0.25329118967056274, 0.44775882363319397, -0.14221414923667908, -0.5685188174247742, 0.1897473782300949, -0.057132963091135025, 0.9523000121116638, -0.49901580810546875, -0.6451709270477295, 0.25010985136032104, -0.10742082446813583, -0.20178447663784027, -0.28554975986480713, -0.22998350858688354, -0.026647301390767097, 0.21699926257133484, -0.4802703261375427, -0.010945325717329979, 0.09140296280384064, 0.019315369427204132, -0.06534942984580994, 0.09549687802791595, 0.17124971747398376, -0.47810810804367065, -0.5478851795196533, 0.29395976662635803, -0.027879051864147186, -0.20965541899204254, 0.1543755978345871, 0.46004825830459595, 0.1418730765581131, 0.16788792610168457, -5.635417461395264, -0.3359338939189911, -0.18478821218013763, -0.027054881677031517, 0.7245256900787354, -0.4454914331436157, 0.9447176456451416, -0.12853044271469116, 0.31310945749282837, -0.004493714310228825, 0.48737606406211853, -0.30581414699554443, 0.05517634004354477, -0.20563483238220215, -0.06722915172576904, 0.07213683426380157, -0.05207193270325661, 0.2849977910518646, 0.7764995098114014, -0.16089493036270142, 0.4811035990715027, -0.7353103756904602, -0.02998153306543827, 0.4808189272880554, 0.059975989162921906, 0.010280290618538857, -0.8614829182624817, 0.15697677433490753, -0.7851960062980652, -0.15770982205867767, -0.0854196548461914, -0.43954721093177795, -0.1910032033920288, -0.30514541268348694, -0.13396355509757996, -0.32113146781921387, 0.06727850437164307, 0.24685466289520264, -0.14960059523582458, -0.37877434492111206, 0.596155047416687, 0.0272197425365448, 0.16664066910743713, -0.3598480820655823, -0.19370320439338684, -0.34004902839660645, -0.4454191327095032, 0.008544158190488815, -0.05723073333501816, 0.6483503580093384, -0.4529469907283783, -0.044866517186164856, 0.5528848171234131, 0.3188537061214447, 0.4773083031177521, -0.08674352616071701, 0.24004514515399933, 0.36199983954429626, -0.1299535632133484, -0.17199820280075073, 0.05632119998335838, -0.2547313868999481, -0.08162343502044678, -0.7069849967956543, -0.03357164189219475, 0.44355326890945435, -0.38019269704818726, 0.03821789100766182, 0.21958360075950623, 0.2009098082780838, -0.4524374008178711, 0.31378811597824097, -0.36611849069595337, -0.8110274076461792, 0.3325830101966858, -0.45480260252952576, 0.23792460560798645, 0.16894501447677612, 0.14269500970840454, -0.1159406304359436, -0.013921328820288181, -0.30339595675468445, -0.050827331840991974, -0.0058153425343334675, 0.11375704407691956, -0.7332497835159302, -0.3565567135810852, -0.18080054223537445, -0.13373784720897675, 0.3636442720890045, 0.03664231672883034, -0.2197251319885254, 0.35328152775764465, 0.45269447565078735, 0.3885091245174408, -0.42468950152397156, -0.2028510570526123, 0.9713127613067627, 0.6920503973960876, 0.18407480418682098, 0.8008221387863159, -0.03535529598593712, -0.3667900860309601, -0.21907439827919006, 0.16553014516830444, 0.006866325158625841, -0.6709451675415039, 0.5469861030578613, 0.7009114623069763, -0.2769949734210968, 0.17845778167247772, 0.23988552391529083, -0.39494508504867554, -0.4463675618171692, 0.364833801984787, -0.10285874456167221, 0.07670755684375763, 0.4181922972202301, 0.549626886844635, -0.15623463690280914, -0.001550365355797112, 0.4035790264606476, -0.6703905463218689, 0.10690934956073761, -0.0962958037853241, -0.03435736522078514, 0.37421154975891113, 0.40166550874710083, -0.4620731472969055, -0.19696608185768127, 0.18962709605693817, 0.17692342400550842, -0.42357853055000305, -0.6385813355445862, 0.2669946551322937, -0.4842795431613922, -0.3195926547050476, 0.41194596886634827, 0.06351754069328308, 0.06460752338171005, -0.23338647186756134, -0.19958727061748505, 0.0020879325456917286, -0.11156915128231049, 0.2611025869846344, 0.41282233595848083, 0.38825666904449463, 0.5216905474662781, 0.21341250836849213, -0.25450631976127625, 0.13515417277812958, 0.031818486750125885, 0.12387294322252274, -0.1386406421661377, 0.07523805648088455, -0.2913370728492737, 0.4874201714992523, 0.45695143938064575, 0.30855873227119446, -0.699679434299469, -0.25482648611068726, 0.3955563008785248, -0.5190548896789551, 0.042460158467292786, -0.3395482897758484, -0.4125620126724243, 0.268560528755188, -0.5851316452026367, -0.18633265793323517, 0.14862264692783356, -0.46212685108184814, 0.38711827993392944, 0.14455509185791016, -0.17006342113018036, -0.45119255781173706, -0.6506901383399963, -0.04973553121089935, -0.041471097618341446, -0.14119449257850647, 0.18222597241401672, 0.21247538924217224, -0.0722341388463974, 0.024202395230531693, -0.09802521765232086, 0.16002225875854492, 0.009951791726052761, -0.2188064604997635, -0.1453821361064911, -0.20194761455059052, -0.4927259683609009, -0.19690437614917755, 0.007378744427114725, 0.44602733850479126, -0.4184138774871826, -0.047527506947517395, 0.38679951429367065, 0.44147348403930664, 0.45294463634490967, -0.05593622475862503, -0.8524971008300781, -0.03223114833235741, 0.7165677547454834, -0.3166409134864807, 0.17929236590862274, 0.6423076391220093, 0.1599540114402771, 0.07804456353187561, 0.12114255875349045, -0.25165998935699463, 0.05670953541994095, -0.34960493445396423, -0.6705524921417236, 0.785468339920044, 0.14873185753822327, 0.03353333845734596, -0.20536087453365326, 0.11584210395812988, -0.0004010485135950148, 0.1880067139863968, -0.26052790880203247, 0.4531610906124115, -0.26964133977890015, 0.5028757452964783, -0.06649335473775864, -0.7141209244728088, 0.3768731355667114, 0.5478300452232361, -0.7708252668380737, 0.1592848300933838, -0.14743110537528992, 0.4002644717693329, -0.5877906680107117, 0.13692276179790497, 0.020818520337343216, -0.2611646354198456, -0.5313938856124878, -0.16449394822120667, 0.5737915635108948, -0.29911622405052185, 0.7997336387634277, 0.19958966970443726, 0.6727786660194397, -0.198861762881279, -0.06712557375431061, 0.11585397273302078, 0.15931673347949982, 0.17517133057117462, -0.2724473774433136, 0.06260751187801361, 0.20827840268611908, 0.059565797448158264, -0.10209409147500992, -0.09789339452981949, 0.8884460926055908, 1.0748142004013062, 0.17640572786331177, -0.18186284601688385, -0.12421535700559616, -0.5313748717308044, 0.5222551226615906, -0.4582659602165222, 0.7350988984107971, 0.0585956871509552, 0.30522850155830383, 0.21845810115337372, 0.044879987835884094, -0.5173379778862, -0.5524407625198364, 0.926572322845459, 0.1368461400270462, -0.16760298609733582, -0.07461114227771759, 0.3903810381889343, 0.05723625794053078, -0.38124483823776245, 0.15938328206539154, 0.21230655908584595, 0.050333358347415924, 0.41987407207489014, 0.04935000464320183, -0.6113187074661255, -0.4665065109729767, 0.921135425567627, -0.01145138218998909, 0.11172156780958176, -0.5093719363212585, -0.29199814796447754, -0.3474028706550598, 0.265162855386734, 0.3209380805492401, -0.3914113938808441, -0.013895516283810139, -0.6651047468185425, -0.46614307165145874, -0.2058926522731781, 0.4578007459640503, 0.263761043548584, -0.20502535998821259, -0.3934735655784607, 0.7607549428939819, -0.6864615082740784, 0.2567567229270935, 0.7196170091629028, -0.4325440227985382, -0.2093498706817627, 0.10930946469306946, 0.13072673976421356, 0.4694839417934418, -0.7416542768478394, -0.3223226070404053, 0.14041359722614288, -0.366144597530365, 0.5851866602897644, -0.048442743718624115, -0.5758548378944397, -0.1371760070323944, -0.2305462509393692, 0.20652997493743896, -0.10545547306537628, 0.31780022382736206, 0.05239259824156761, 0.4036566913127899, 0.21555180847644806, -0.06708414852619171, -0.40744665265083313, 0.408086359500885, 0.12499330192804337, -0.06135936453938484, -0.14118658006191254, 1.0664944648742676, 0.30197086930274963, 0.2963094115257263, -0.3486502468585968, 0.9464717507362366, 0.15055090188980103, -0.20567132532596588, -0.15395192801952362, -0.8108423352241516, 0.36177268624305725, 0.03530597314238548, 0.8034052848815918, 0.1411062628030777, -0.4542143642902374, -0.10030937194824219, 0.5908194184303284, 0.14786234498023987, 0.18116718530654907, -0.22013884782791138, 0.20959453284740448, 0.519940197467804, 0.3962900638580322, -0.37101954221725464, -0.08262498676776886, 0.08639279007911682, -0.23523437976837158, 0.2487572878599167, 0.9053064584732056, -0.5081285238265991, -0.07605724036693573, 0.03879861161112785, -0.24825714528560638, -0.05183560401201248, 0.06797344982624054, 1.198759913444519, -0.26861903071403503, -0.03441854193806648, 0.35471096634864807, 0.06853364408016205, 0.7598915696144104, 0.3109467625617981, 0.08305715769529343, -0.002777037676423788, -0.22688409686088562, 0.5561319589614868, 0.5118635892868042, -0.08391832560300827, 0.12980881333351135, -0.002445993712171912, 0.41076087951660156, 0.33289864659309387, -0.7023184299468994, 0.0996217206120491, 0.14078089594841003, -0.33475229144096375, -0.7128531336784363, -0.3913525342941284, -0.0453222282230854, -0.6053775548934937, 0.020113712176680565, 0.15389877557754517, 0.2054089456796646, -0.9580127000808716, 0.1752009093761444, -0.07117091119289398, -0.12896989285945892, -0.22291333973407745, -0.3108740746974945, -0.19898423552513123, 0.20430399477481842, 0.3853510320186615, -0.6031635999679565, 0.20932163298130035, 0.016047511249780655, 0.11937952041625977, -0.036969393491744995, 0.2948905825614929, -0.13548541069030762, -0.683678925037384, -0.2902928590774536, -0.0721987783908844, 1.1966590881347656, 0.6020187139511108, -0.16879233717918396, -0.015340634621679783, -0.05616478994488716, 0.06391496956348419, -0.16590198874473572, -0.3242056369781494, 0.6111645102500916, -0.39810964465141296, 0.13236097991466522, -0.16702629625797272, 0.5076020359992981, 0.031047256663441658, -0.28086209297180176, 0.138227179646492, 0.22623208165168762, 0.6162401437759399, -0.7483623027801514, 0.5551452040672302, -0.1158166229724884, 0.3103668987751007, -0.4313805103302002, -0.23655655980110168, -0.3141610026359558, 0.5692272782325745, -0.311587929725647, 0.03916551545262337, -0.18187062442302704, 0.05417115241289139, 0.1760285347700119, 0.22111429274082184, -0.40279340744018555, -0.13336020708084106, 0.16938093304634094, -0.032205112278461456, -0.2679883539676666, -0.9071673154830933, -0.8348327279090881, 0.41049155592918396, 0.43771955370903015, -0.20384657382965088, -0.20655541121959686, 0.20593281090259552, 0.023658722639083862, -0.18427933752536774, 0.14456428587436676, -0.18516936898231506, -0.12161380052566528, 0.4341367781162262 ]
OBJECTIVE To examine the safety of using aliskiren combined with agents used to block the renin-angiotensin system. DESIGN Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES Medline, Embase, the Cochrane Library, and two trial registries, published up to 7 May 2011. STUDY SELECTION Published and unpublished randomised controlled trials that compared combined treatment using aliskiren and angiotensin converting enzyme inhibitors or angiotensin receptor blockers with monotherapy using these agents for at least four weeks and that provided numerical data on the adverse event outcomes of hyperkalaemia and acute kidney injury. A random effects model was used to calculate pooled risk ratios and 95% confidence intervals for these outcomes. RESULTS 10 randomised controlled studies (4814 participants) were included in the analysis. Combination therapy with aliskiren and angiotensin converting enzyme inhibitors or angiotensin receptor blockers significantly increased the risk of hyperkalaemia compared with monotherapy using angiotensin converting enzymes or angiotensin receptor blockers (relative risk 1.58, 95% confidence interval 1.24 to 2.02) or aliskiren alone (1.67, 1.01 to 2.79). The risk of acute kidney injury did not differ significantly between the combined therapy and monotherapy groups (1.14, 0.68 to 1.89). CONCLUSION Use of aliskerin in combination with angiotensin converting enzyme inhibitors or angiotensin receptor blockers is associated with an increased risk for hyperkalaemia. The combined use of these agents warrants careful monitoring of serum potassium levels.
[ 0.03104683756828308, 0.0200432650744915, -0.010881621390581131, 0.018475499004125595, -0.021855514496564865, 0.0035276361741125584, 0.009763021022081375, -0.01520026009529829, -0.017662949860095978, -0.0014027003198862076, -0.008270190097391605, 0.015809455886483192, -0.004212014842778444, 0.011985886842012405, -0.0010475199669599533, -0.03043147176504135, -0.024823671206831932, 0.03373557701706886, 0.005893378052860498, 0.011882087215781212, 0.015605606138706207, 0.018464792519807816, 0.009616563096642494, 0.0028343116864562035, -0.00647675059735775, 0.01721290871500969, 0.010619862005114555, -0.0033731393050402403, 0.011997677385807037, -0.010166848078370094, 0.004116381984204054, 0.000999661860987544, 0.01408318243920803, 0.009474821388721466, 0.01177527941763401, 0.0140712670981884, -0.003784226719290018, 0.013320466503500938, 0.05109221488237381, -0.004011324606835842, 0.0010604644194245338, -0.008484998717904091, 0.005292945541441441, -0.0036710076965391636, -0.009696734137833118, -0.020644474774599075, -0.0012685984838753939, -0.006579125300049782, -0.01727459207177162, 0.002514077350497246, 0.005903731565922499, -0.006030299235135317, -0.01047802809625864, 0.0018123863264918327, -0.00550040602684021, -0.0018630847334861755, 0.019140925258398056, -0.019956465810537338, -0.016519028693437576, -0.018914511427283287, -0.004424803890287876, -0.0035287970677018166, 0.011944237165153027, -0.007965123280882835, 0.005107041448354721, -0.06691600382328033, 0.009118448942899704, -0.01315396185964346, 0.004340485669672489, 0.00030148914083838463, 0.02577843889594078, 0.0204203762114048, -0.005153668113052845, -0.038031190633773804, -0.012373821809887886, -0.026779230684041977, 0.003631533356383443, -0.004117039032280445, 0.009268698282539845, 0.00074439262971282, -0.015138083137571812, 0.002180524170398712, 0.0017508352175354958, 0.002049819566309452, 0.002810050267726183, 0.01144786924123764, -0.01601697877049446, -0.014550468884408474, 0.0035402504727244377, -0.016431719064712524, -0.009613722562789917, -0.0028842713218182325, -0.0039834994822740555, 0.0066044945269823074, 0.006289396435022354, -0.018800796940922737, -0.026023976504802704, -0.0038238530978560448, 0.010128669440746307, -0.03069368377327919, -0.023800905793905258, -0.005382121074944735, 0.01666460558772087, -0.0024487373884767294, 0.020417094230651855, 0.011898687109351158, 0.0017763003706932068, 0.011097310110926628, -0.016314063221216202, 0.005730877164751291, -0.0038615199737250805, 0.02014119178056717, 0.014253324829041958, 0.003136270446702838, 0.018702596426010132, 0.029074469581246376, 0.0044776699505746365, -0.017181135714054108, 0.013497661799192429, -0.0062684412114322186, 0.04680897295475006, -0.021065156906843185, 0.00671529583632946, -0.02643791399896145, -0.001002642558887601, 0.01696925237774849, 0.00909416563808918, 0.00204098760150373, -0.007583341561257839, 0.012178627774119377, -0.008903414011001587, -0.02224477007985115, -0.014298252761363983, -0.014001574367284775, -0.003604352939873934, 0.0021952404640614986, -0.012262757867574692, 0.01023703720420599, -0.008784182369709015, 0.005062032025307417, -0.02703903615474701, 0.010233256965875626, -0.005596629343926907, 0.019896840676665306, 0.0227048322558403, 0.00877259112894535, 0.003546719439327717, -0.002813262864947319, 0.010264551267027855, 0.004713987931609154, 0.008143790997564793, -0.003759012557566166, -0.007047872059047222, -0.018345246091485023, 0.009673921391367912, 0.02376798912882805, -0.008142773993313313, -0.004884813912212849, -0.012264810502529144, 0.00369592965580523, -0.020410962402820587, 0.0033245186787098646, 0.017267508432269096, 0.008675649762153625, -0.018203604966402054, -0.011140839196741581, -0.02493271976709366, 0.009829424321651459, -0.020757615566253662, -0.0028435022104531527, -0.002785071963444352, 0.0004009923432022333, 0.005272105801850557, 0.0088168540969491, -0.014042558148503304, -0.00494951568543911, -0.0254868995398283, 0.008623672649264336, -0.002956937998533249, 0.06652236729860306, 0.014048339799046516, -0.02048865705728531, 0.020086444914340973, 0.010523648001253605, 0.002043337095528841, -0.010105960071086884, 0.026545511558651924, 0.004170820116996765, -0.02211165800690651, 0.0038253061939030886, -0.005950906313955784, -0.01903809793293476, -0.02324739843606949, 0.009852202609181404, -0.010169272311031818, 0.0024192961864173412, 0.011020527221262455, 0.007518704980611801, -0.0190463624894619, 0.021004093810915947, 0.020857837051153183, -0.003761842381209135, 0.04419019818305969, -0.022713499143719673, 0.019162077456712723, 0.003323851153254509, -0.000930112088099122, -0.03683118894696236, -0.009995690546929836, -0.0003796340897679329, 0.02679755911231041, 0.009952716529369354, -0.011444749310612679, -0.0055140480399131775, 0.008112371899187565, 0.009847542271018028, -0.025301221758127213, -0.0035342429764568806, 0.017931202426552773, -0.016436409205198288, 0.0013444283977150917, 0.02058359980583191, -0.008184333331882954, -0.027706190943717957, 0.023910026997327805, -0.012291033752262592, 0.001883016200736165, 0.014139007776975632, -0.003847191110253334, 0.0055877394042909145, -0.007446778006851673, -0.000055174343287944794, -0.014193374663591385, 0.01844213902950287, 0.018897850066423416, 0.014601071365177631, 0.014948384836316109, 0.0064154756255447865, 0.008835570886731148, -0.009947097860276699, 0.0036209519021213055, 0.015325184911489487, 0.015930544584989548, 0.030406441539525986, 0.02029285952448845, -0.006956426426768303, 0.010074693709611893, 0.0023052177857607603, -0.0057092332281172276, 0.0032652535010129213, 0.004758344031870365, -0.009225151501595974, 0.0022875946015119553, 0.013904338702559471, 0.01445453055202961, -0.014225899241864681, -0.024297216907143593, 0.017544301226735115, 0.02555437944829464, 0.0027098653372377157, -0.0022309147752821445, 0.0034063176717609167, -0.038684993982315063, 0.007827522233128548, -0.0026419060304760933, -0.019524987787008286, 0.004271712154150009, 0.004033277276903391, 0.0027563630137592554, -0.007508464157581329, 0.008250446990132332, -0.01016896404325962, -0.009770357050001621, -0.08195623010396957, -0.008571494370698929, 0.0011995977256447077, -0.018283504992723465, 0.007772493176162243, 0.0027377442456781864, -0.008616967126727104, 0.021827692165970802, -0.013240433298051357, 0.03396669030189514, -0.02295111119747162, 0.023028355091810226, -0.006180093623697758, 0.03417385369539261, 0.003642825409770012, -0.0033323122188448906, 0.00569535419344902, 0.016674675047397614, 0.0014109914191067219, 0.00032634101808071136, 0.017683394253253937, 0.006618749350309372, -0.01757996156811714, -0.007484143599867821, -0.032722100615501404, 0.01942599192261696, -0.019347382709383965, 0.009090811014175415, -0.034599363803863525, 0.005962671712040901, -0.03141188621520996, -0.045439593493938446, -0.01464182510972023, 0.00998188927769661, -0.00554816285148263, 0.0177164264023304, 0.0154348686337471, -0.03670654818415642, -0.009921956807374954, 0.008528158068656921, 0.0009426898322999477, 0.019435234367847443, 0.026479560881853104, 0.006530896294862032, 0.01737832836806774, 0.0217336006462574, -0.013747025281190872, 0.040740396827459335, 0.009808928705751896, -0.011508005671203136, 0.0013497746549546719, -0.010065993294119835, -0.006472728215157986, 0.020587792620062828, 0.0017378859920427203, -0.014581404626369476, 0.0017408705316483974, 0.04386831074953079, -0.007200021296739578, -0.005675176624208689, -0.004978272132575512, -0.015267444774508476, 0.011239729821681976, 0.020550942048430443, -0.008504461497068405, -0.022160572931170464, -0.0012903906172141433, 0.025301294401288033, -0.008083698339760303, 0.0023654885590076447, 0.003130091819912195, -0.013019496574997902, -0.026740266010165215, -0.000755154702346772, -0.013558246195316315, -0.010318158194422722, -0.016020752489566803, -0.001964257564395666, 0.022028282284736633, 0.016522236168384552, 0.04145429655909538, 0.014392458833754063, -0.03165450692176819, 0.005840376019477844, -0.012856554239988327, -0.01971987634897232, 0.006838998757302761, -0.0023438739590346813, 0.004902403801679611, -0.014919433742761612, 0.013078643009066582, 0.007826380431652069, 0.0028063366189599037, 0.009835580363869667, 0.009541042149066925, -0.013122733682394028, -0.026904013007879257, 0.016705287620425224, -0.011730710044503212, 0.006862200330942869, -0.008173924870789051, -0.000497664324939251, -0.008351974189281464, -0.011640241369605064, -0.0020318038295954466, 0.006132159847766161, -0.01507322397083044, 0.0029389155097305775, -0.014411423355340958, -0.005837659817188978, -0.0009436905384063721, -0.018490247428417206, -0.00736882071942091, 0.04713292419910431, 0.004640501923859119, -0.004135238006711006, 0.011009467765688896, 0.0007889815606176853, 0.07245707511901855, -0.00094198202714324, -0.002912635449320078, -0.012068433687090874, 0.00819757767021656, -0.01935664191842079, 0.008919663727283478, 0.006617031991481781, 0.0046076057478785515, -0.005840059369802475, 0.012631524354219437, -0.040571428835392, 0.016617510467767715, -0.001310243969783187, -0.002265759278088808, -0.013182668946683407, -0.01075771078467369, -0.012760868296027184, 0.020030679181218147, -0.0044817873276770115, -0.013791442848742008, 0.009052681736648083, 0.019016249105334282, -0.01108941063284874, -0.003931981977075338, -0.00601410074159503, 0.015933234244585037, -0.014426207169890404, -0.01155454944819212, -0.0005683433264493942, -0.00002367328852415085, -0.019084090366959572, -0.005852392874658108, 0.0029896353371441364, -0.012457340955734253, 0.02453223615884781, 0.006084229797124863, 0.018447402864694595, 0.005783426109701395, 0.01596720889210701, 0.017735008150339127, -0.00991642102599144, 0.021174177527427673, 0.003401452209800482, -0.0005293600261211395, 0.0416131317615509, -0.01814913935959339, -0.012055699713528156, 0.007727541029453278, -0.005935666151344776, -0.010258175432682037, 0.0063676973804831505, 0.013142967596650124, -0.002196746412664652, 0.0013155387714505196, 0.011859438382089138, 0.0017897593788802624, 0.004039956256747246, 0.01609238050878048, -0.04052956402301788, -0.01862984336912632, -0.032705388963222504, 0.014818210154771805, 0.00737332459539175, -0.004081228747963905, -0.015887098386883736, 0.0016277532558888197, -0.005708382464945316, -0.04014158993959427, -0.007398074492812157, -0.01757894456386566, -0.007080582901835442, 0.0089002326130867, 0.0030375979840755463, -0.010021028108894825, -0.025842713192105293, -0.006928722374141216, -0.013727189972996712, 0.006939101032912731, 0.01850607432425022, -0.012127858586609364, 0.021292995661497116, 0.028425732627511024, 0.010375737212598324, -0.0027459552511572838, 0.01105527114123106, -0.028678007423877716, -0.07516668736934662, -0.004543466959148645, 0.014081239700317383, -0.007447607349604368, 0.002037490950897336, 0.0007462173234671354, -0.019879773259162903, 0.019372761249542236, 0.013720760121941566, 0.00026176602113991976, 0.03682401776313782, 0.010851690545678139, -0.00028122845105826855, 0.009433036670088768, 0.013158971443772316, 0.00571503397077322, -0.02220134064555168, -0.013913566246628761, -0.003698357380926609, 0.01035383716225624, 0.01268351823091507, 0.02118079550564289, -0.040654346346855164, 0.008467916399240494, 0.00612129271030426, -0.08102148771286011, -0.012592442333698273, -0.01256299577653408, -0.01599910296499729, -0.009203905239701271, 0.010390831157565117, 0.020486317574977875, -0.02230783738195896, -0.017787039279937744, -0.017833460122346878, 0.010749430395662785, 0.022283829748630524, 0.00995402317494154, 0.0038551862817257643, 0.009900558739900589, -0.0008656884310767055, 0.01725115440785885, -0.013750378042459488, 0.015123404562473297, -0.0005865199491381645, -0.002320361090824008, -0.02431301772594452, -0.006074827164411545, 0.003569654654711485, -0.006969849579036236, -0.025750424712896347, 0.011934434995055199, 0.022196941077709198, 0.009986905381083488, -0.013180703856050968, 0.001354921143501997, -0.007153471931815147, -0.018793605268001556, -0.019897110760211945, -0.01799474097788334, -0.00977025181055069, -0.007003625854849815, 0.006073633208870888, -0.04057177156209946, -0.027921168133616447, -0.003768014255911112, 0.013214576058089733, 0.021174952387809753, -0.011392301879823208, -0.005440793000161648, 0.012582700699567795, 0.006132137030363083, -0.009734735824167728, 0.025912493467330933, 0.010558419860899448, 0.00621628575026989, 0.02311425283551216, 0.005355070810765028, -0.0030924207530915737, 0.009303308092057705, 0.02021804265677929, -0.01136852614581585, 0.006420702673494816, 0.0019774253014475107, 0.007696487009525299, 0.006304972339421511, 0.007277468219399452, -0.00024002720601856709, 0.07166410982608795, 0.00797905120998621, 0.0027865294832736254, -0.01453150063753128, -0.011121504940092564, -0.000995301059447229, 0.026645254343748093, -0.014158667996525764, -0.00853611808270216, -0.02211100608110428, 0.00868273340165615, -0.008942162618041039, -0.011133273132145405, 0.006176515482366085, -0.0022310400381684303, -0.014061820693314075, 0.0022832071408629417, -0.001693250611424446, 0.02714025229215622, -0.003509228816255927, 0.0019192383624613285, -0.015833910554647446, -0.02697071060538292, 0.003634645836427808, -0.01248599961400032, -0.013527162373065948, -0.031717970967292786, -0.0011887256987392902, -0.008455419912934303, -0.006194032728672028, -0.012004304677248001, -0.002506795572116971, 0.004108470864593983, 0.025940801948308945, -0.003103518858551979, -0.026916000992059708, 0.0049817441031336784, 0.005124729126691818, -0.02536524273455143, -0.029006507247686386, 0.00803872849792242, -0.013156312517821789, 0.0017739926697686315, -0.022174451500177383, 0.009815397672355175, 0.009278743527829647, 0.00975630059838295, -0.012360796332359314, -0.006148640066385269, -0.0016224989667534828, -0.019646747037768364, 0.0005877759540453553, -0.0027306126430630684, -0.0253414548933506, 0.024124804884195328, 0.0070028891786932945, -0.0337698832154274, 0.016871895641088486, -0.0030249287374317646, -0.020528443157672882, 0.0075347875244915485, -0.007598071824759245, -0.01163499429821968, -0.015176287852227688, 0.026951009407639503, 0.016332443803548813, 0.0040923492051661015, -0.007795906625688076, 0.00009386241436004639, 0.006958698853850365, -0.047968313097953796, -0.00335671310313046, -0.0025367233902215958, 0.0023470476735383272, 0.018024375662207603, 0.01268511638045311, -0.02608669362962246, -0.01982688158750534, 0.000504972180351615, -0.004729790147393942, -0.008152180351316929, 0.021203335374593735, -0.008077431470155716, 0.005643206648528576, -0.015894312411546707, -0.014277217909693718, -0.009041952900588512, -0.002993957605212927, -0.004521974362432957, 0.011100511997938156, 0.030364517122507095, 0.008659248240292072, -0.0009985053911805153, -0.000011248048394918442, 0.004894785117357969, 0.03452369198203087, -0.013775676488876343, 0.0057090152986347675, -0.01140779908746481, 0.009496663697063923, -0.015569299459457397, 0.0008922507986426353, 0.0009117035660892725, 0.018740011379122734, -0.007253977470099926, -0.003939787857234478, 0.002542189322412014, 0.011928840540349483, -0.018986504524946213, 0.0005447114817798138, 0.014070972800254822, -0.01128181628882885, 0.01940952241420746, 0.001977529376745224, 0.013560030609369278, 0.026338005438447, 0.008308042772114277, 0.006761863827705383, 0.009296081028878689, -0.011348442174494267, -0.01482146792113781, -0.004146045073866844, 0.019676003605127335, 0.02280636504292488, -0.0006274688057601452, -0.02248285710811615, -0.010714384727180004, -0.0032006334513425827, 0.0023367879912257195, 0.005299398209899664, 0.013724904507398605, 0.01445821113884449, -0.014552023261785507, -0.022308290004730225, -0.021405525505542755, -0.0019175438210368156, -0.04343113675713539, 0.004354868549853563, 0.0068542626686394215, -0.027794167399406433, 0.02501741424202919, 0.004195480141788721, 0.003478728700429201, 0.010653902776539326, 0.008763779886066914, -0.01961047574877739, -0.007253331132233143, 0.01452547125518322, 0.0013940230710431933, -0.007903768680989742, -0.0201500803232193, 0.0031676716171205044, 0.019965067505836487, 0.00008161022560670972, -0.002730598207563162, 0.013026038184762001, 0.008523640222847462, 0.01051575131714344, -0.027037356048822403, -0.0014590511564165354, 0.006533420644700527, -0.012805349193513393, 0.01320323534309864, 0.007188767194747925, -0.005221955943852663, 0.005674729123711586, -0.03199096769094467, 0.014212026260793209, 0.030767973512411118, 0.015908826142549515, 0.015336047857999802, -0.014338323846459389, -0.014616850763559341, 0.01688041165471077, -0.019814860075712204, 0.007712536491453648, -0.027306992560625076, 0.004373576492071152, -0.003525295527651906, 0.015235691331326962, 0.016278088092803955, -0.03969339281320572, -0.010018857195973396, -0.006431720219552517, -0.00042365677654743195, 0.002045416971668601, -0.004078744910657406, -0.012211134657263756, 0.024017401039600372, 0.019364019855856895, 0.0033565256744623184, 0.0011263624764978886, -0.016283007338643074, 0.015386972576379776, -0.02029193937778473, 0.000641405931673944, 0.018581300973892212, -0.026338323950767517, -0.0073319897055625916, 0.019156407564878464, -0.00522335059940815, 0.013544851914048195 ]
[ 0.21268145740032196, 0.05319391191005707, 0.14331024885177612, -0.21273158490657806, -0.3290651738643646, 0.4056059718132019, 0.450442910194397, -0.8112815618515015, 0.23225611448287964, 0.15324200689792633, 0.08115934580564499, 0.46253737807273865, -0.33891183137893677, 0.04014376178383827, 0.019248217344284058, 0.9304185509681702, 0.6505824327468872, -0.06141534075140953, 0.07003544270992279, -0.43835657835006714, -0.10225605964660645, 0.03809571638703346, 0.4686022400856018, -0.0834130123257637, 0.2935783267021179, 0.3349052667617798, 0.8057515025138855, 0.19079653918743134, 0.04039908945560455, 0.0942828357219696, 0.0030503703746944666, 0.5812923312187195, -0.23400728404521942, -0.49188870191574097, 0.09204930067062378, 0.8622536063194275, 0.3325181305408478, 0.10018174350261688, 0.07854492217302322, -0.7731930017471313, -0.13801875710487366, 0.02239987440407276, -0.48402807116508484, 0.5527568459510803, -0.029983554035425186, -0.261893093585968, -1.4679406881332397, -0.19296032190322876, -0.21799129247665405, 0.19628776609897614, 0.3289901614189148, 0.3273162245750427, 0.23956866562366486, 0.07563324272632599, 0.14980176091194153, 0.637958824634552, -0.1997198909521103, -0.40366098284721375, 0.06951112300157547, 0.22851982712745667, -0.09871853142976761, -0.019227003678679466, 0.15740714967250824, 0.7139583230018616, 0.3269823491573334, 0.3762986660003662, 0.01951230876147747, 0.008655345067381859, -0.3313542604446411, -0.24094955623149872, -0.09087339788675308, 0.004026716575026512, -0.3730217516422272, 0.2805667817592621, -0.20449396967887878, -0.1615714728832245, -0.2560326159000397, -0.04188094288110733, 0.17855122685432434, 0.3166824281215668, 0.6850721836090088, 0.06611957401037216, 0.04953932389616966, -0.31995537877082825, 0.15348097681999207, 0.5049012303352356, -0.3695598840713501, 0.5397436618804932, -0.49075594544410706, -0.10342799872159958, 0.06971218436956406, -0.6714721918106079, 0.7306647300720215, 0.680176317691803, -0.005055345129221678, 0.22434823215007782, -0.08280070126056671, -0.09689967334270477, -0.02668854594230652, -0.01300140656530857, 0.12509742379188538, 0.2558954954147339, -0.5788470506668091, -0.13102507591247559, -0.8779793977737427, -0.04968833923339844, -0.6296530365943909, -0.9515188336372375, -0.8948265314102173, 0.33557841181755066, -0.7950426936149597, 0.7423104643821716, 0.029032621532678604, -0.20766790211200714, -0.586825966835022, 0.1685565859079361, 0.020598845556378365, -0.2403912991285324, 0.009137053973972797, 0.8667725920677185, -0.0006485068588517606, 0.8049914836883545, -0.1886100322008133, 0.45936119556427, 0.30224642157554626, -0.02449117600917816, 0.5485172867774963, 0.30650728940963745, -0.08157674223184586, 0.7561383843421936, -0.12665949761867523, 0.22361238300800323, -0.29754185676574707, -0.030790595337748528, -0.29622676968574524, -0.38872984051704407, 0.1452304720878601, -0.0793638825416565, 0.007343398407101631, 0.15992692112922668, -0.5108917355537415, -0.4743930697441101, -0.1449480950832367, -0.5119596719741821, -0.06908337771892548, -0.3985801637172699, 0.38134443759918213, 0.37730148434638977, -0.3283322751522064, -0.3604004383087158, 0.26936423778533936, 0.045640334486961365, -0.3423563838005066, -0.34763872623443604, -0.20018485188484192, 0.6980491280555725, -0.47993218898773193, -0.4650755226612091, 0.06069744750857353, -0.17364367842674255, 0.5304274559020996, 0.30410993099212646, -0.43865975737571716, -0.023439504206180573, 0.41651615500450134, -0.12824669480323792, -0.03213190287351608, 0.2728399932384491, 0.7138541340827942, -0.2995413541793823, -0.14517517387866974, -0.4383011758327484, 0.1327556073665619, -0.30052492022514343, -0.4019412398338318, -0.07825811207294464, 0.5390300750732422, 0.27175483107566833, 0.20484009385108948, -0.15051476657390594, -0.5901848077774048, -0.12804360687732697, -0.12189088016748428, -0.45516207814216614, 0.16536803543567657, 0.4165768027305603, 0.7234734296798706, 0.1872284710407257, 0.1489313542842865, 0.7552775740623474, 0.1957211196422577, -0.1253867894411087, 0.08996066451072693, -0.9025144577026367, 1.5359151363372803, -0.48183587193489075, -0.6911139488220215, 1.016261100769043, -0.08436007052659988, -0.022597771137952805, 0.24160881340503693, 0.2756842076778412, 0.3766539990901947, -0.21841174364089966, -0.4351748526096344, -0.2138785868883133, 0.14404860138893127, -0.3701435327529907, -0.6791488528251648, 0.9024836421012878, 0.36129364371299744, -0.2743375301361084, -0.3009661138057709, -0.2841636538505554, 0.3019408583641052, 0.1169862300157547, 0.05005885288119316, 0.5958364605903625, 0.12845179438591003, 0.397470086812973, 0.5830851197242737, -0.3390648663043976, 0.31117257475852966, 0.5267271995544434, 0.10598713159561157, 0.3563942611217499, 0.6270031332969666, -0.07839470356702805, 0.40457868576049805, -0.8445274829864502, 0.01603551395237446, -0.14322303235530853, 0.3375212252140045, -0.17983371019363403, -0.0780688002705574, -0.06054012477397919, -0.2709848880767822, -0.2508823275566101, 0.5893957614898682, -0.06435726583003998, 0.08420877903699875, 0.08346085995435715, 0.058283377438783646, 0.33238086104393005, 0.4115934669971466, -0.20049899816513062, -0.1403101235628128, 0.3472251296043396, -0.7808873057365417, -0.44148170948028564, 0.18422970175743103, -0.09498873353004456, 0.10985264182090759, -0.32476744055747986, 0.18964320421218872, 0.11007364094257355, 0.08286898583173752, -0.6714881658554077, -0.2266017347574234, -0.17535719275474548, -0.35950568318367004, 0.2274072915315628, 0.45046496391296387, -0.06900258362293243, 0.5839554667472839, -0.5319779515266418, -0.6003851294517517, -0.44454076886177063, 0.39326211810112, 0.44971996545791626, 0.7652944326400757, 0.25431957840919495, -0.3309653103351593, 0.12887226045131683, -0.11531058698892593, -0.2223203480243683, 0.28745201230049133, 0.5659366846084595, -0.8783132433891296, -0.7521699070930481, 0.2748335301876068, 0.3218599259853363, 0.41591209173202515, 0.12144092470407486, -0.25689268112182617, -0.2930828332901001, -0.06748801469802856, -0.6693894267082214, -0.35561731457710266, -0.3605233132839203, 0.09907739609479904, 0.4937405288219452, -0.46557095646858215, -0.5269351601600647, 0.18620865046977997, 0.1859247386455536, -0.6024048328399658, 0.5751213431358337, 0.4880669414997101, -0.3068200647830963, -0.19430378079414368, 0.009082655422389507, 0.07237330079078674, 0.038272175937891006, 0.45780161023139954, -0.39506882429122925, -0.27427512407302856, 0.05150285363197327, -5.8703179359436035, -0.08390117436647415, -1.077401876449585, 0.272828608751297, -0.12282802164554596, 0.08849134296178818, 0.5509281158447266, -0.1742894947528839, 0.18679656088352203, -0.13015025854110718, 0.05737796053290367, 0.26043832302093506, 0.29110726714134216, 0.48009973764419556, 0.27527251839637756, 0.32222780585289, 0.39347904920578003, 0.305886447429657, 0.3705694079399109, 0.19257166981697083, 0.26604756712913513, -0.6218811869621277, -0.2973870635032654, 0.4928710460662842, 0.4904613196849823, 0.18529435992240906, -0.5245878100395203, 0.7821179032325745, 0.08682534098625183, -0.10990367084741592, 0.17528210580348969, -0.507104218006134, -0.4046977162361145, -0.13438072800636292, 0.2999314069747925, 0.11166591197252274, 0.21633633971214294, 0.19377818703651428, 0.41623273491859436, -0.4117603302001953, 0.3373250663280487, 0.2022661715745926, -0.07688646763563156, -0.4183298945426941, 0.16096629202365875, -0.202523872256279, 0.14654146134853363, 0.5637063980102539, -0.5232548117637634, 0.5249635577201843, 0.5319544076919556, 0.002153355861082673, 0.005852161906659603, 0.6308091282844543, -0.044758591800928116, -0.45019209384918213, -0.058332979679107666, 0.2523592710494995, -0.3312431573867798, 0.7306186556816101, 0.13946104049682617, -0.17325039207935333, -0.39886030554771423, -0.8009700775146484, -0.4411422312259674, 0.12522125244140625, -0.4997882544994354, -0.6312316060066223, -0.04316016286611557, 0.24364706873893738, -0.7084552049636841, 0.3832603693008423, 0.1086445227265358, -0.649642288684845, 0.17906703054904938, -0.15858358144760132, 0.5866811275482178, 0.19985027611255646, -0.2375233769416809, 0.30486515164375305, -0.5072510242462158, -0.8346389532089233, 0.12495357543230057, 0.23828963935375214, 0.24669800698757172, -0.1811710149049759, -0.05227687209844589, 0.421550989151001, -0.06942061334848404, -0.17131955921649933, 0.4922998249530792, -0.33854958415031433, 0.19188134372234344, 0.7518681287765503, -0.28412991762161255, 0.2165609449148178, 0.6435872316360474, 0.0037572018336504698, 0.5199204683303833, -0.05399564653635025, 0.40307506918907166, 0.13061849772930145, -0.017799627035856247, -1.005382776260376, 0.08315511792898178, -0.14352644979953766, -0.8059130311012268, -0.5531551837921143, 0.5789752006530762, -0.9712856411933899, -0.2614300847053528, -0.2997702956199646, -0.0074737644754350185, 0.3889121413230896, 0.6294981241226196, -0.15721677243709564, -0.0015428013866767287, 0.029523171484470367, -0.011105460114777088, -0.17115014791488647, -0.0559968464076519, 0.1384863406419754, -0.3270292282104492, 0.03418298438191414, -0.23302701115608215, -0.24777856469154358, 0.2124720811843872, 0.5427353382110596, -0.5520263910293579, 0.2583247125148773, 0.417722225189209, 0.6057098507881165, -0.7348505258560181, 0.0031427782960236073, 0.2072988897562027, -0.5668591856956482, -0.6339972019195557, 0.0968959853053093, 0.280286580324173, 0.09372425079345703, 0.48767679929733276, -0.10724013298749924, -0.1314118504524231, -0.1377587765455246, 0.012786137871444225, 0.0772763267159462, 0.1405028998851776, -0.49845078587532043, -0.6412491202354431, -0.16725735366344452, -0.0810084342956543, -0.10218141227960587, 0.12604497373104095, 0.014795336872339249, -0.26780247688293457, 0.17462484538555145, 0.7369899153709412, 0.2878890335559845, 0.1899823397397995, -0.6310444474220276, 0.2216770350933075, 0.18673421442508698, -1.0747748613357544, -0.27555185556411743, 0.44788622856140137, -0.043151162564754486, -0.229777991771698, 0.34908562898635864, 0.23418399691581726, 0.23866377770900726, -0.07633792608976364, -0.571966826915741, -0.07345835119485855, -0.061261702328920364, 0.20084217190742493, 0.3545681834220886, -0.5969967246055603, -0.21906675398349762, -0.22692397236824036, 0.12377282232046127, 0.22869302332401276, -0.7546502947807312, -0.2324575036764145, 0.2635650336742401, 0.9519106149673462, 0.34763744473457336, -0.22449935972690582, -0.3272799849510193, -0.08484005928039551, -0.29985588788986206, 0.038052015006542206, 0.14569179713726044, 0.5377938151359558, 0.061636485159397125, -0.42135512828826904, -0.6386044025421143, 0.021885378286242485, 0.14657804369926453, -0.22344373166561127, -0.4499925971031189, 0.3993888199329376, 0.5032488107681274, 0.10838694125413895, 0.2554261088371277, 0.17054015398025513, -0.6569340825080872, -0.0682891383767128, 0.1657281219959259, -0.10420149564743042, -0.23056639730930328, -0.10518930852413177, -0.7884415984153748, -0.08160534501075745, 0.6305912733078003, -0.39632338285446167, 0.2745901048183441, 0.07449650764465332, -0.06929973512887955, -0.6683571338653564, 0.19377554953098297, 0.37198418378829956, -0.24547839164733887, -0.20457179844379425, -0.021184466779232025, -0.43533244729042053, -0.21716731786727905, 1.115745186805725, -0.9298188090324402, -0.04741625115275383, 0.1126427948474884, -0.4565373659133911, 0.10593727976083755, -0.020606620237231255, -0.04864644631743431, -0.25345465540885925, -0.018489960581064224, -0.5970353484153748, 0.35753878951072693, 0.10630413889884949, -0.2664635479450226, -0.44595304131507874, 0.6284526586532593, -0.04336550459265709, -0.11013039946556091, 0.07044333219528198, 0.3944632411003113, 0.12777948379516602, -0.2885551154613495, -0.694563090801239, -0.22549118101596832, -0.11489225178956985, -0.010842657648026943, 0.1680135428905487, -0.4078463912010193, 0.7374036908149719, -0.04037592187523842, -0.011684900149703026, -0.017249351367354393, -0.07194145023822784, 0.41415590047836304, -0.026022884994745255, -0.0019060244085267186, -0.6349872350692749, -0.42703452706336975, 0.1332560032606125, 0.15571002662181854, 0.09029035270214081, -0.4891791045665741, 0.09119216352701187, -0.20384010672569275, -0.08209779858589172, -0.10083234310150146, 0.21070516109466553, 0.6771005392074585, -0.039548110216856, 0.1142502874135971, -0.16666088998317719, -0.17748306691646576, -0.0069260806776583195, 0.4565329849720001, -0.28139060735702515, -0.25664255023002625, 0.4374036192893982, -0.2716749608516693, 0.1517038196325302, -0.6698874831199646, 0.12411142885684967, 0.30488818883895874, -0.21630242466926575, -0.5591979622840881, 0.1863803118467331, 0.2534472346305847, -0.8037861585617065, -0.5778623223304749, -0.27654317021369934, 0.38739827275276184, -0.1419643759727478, 0.12044614553451538, 0.0022477118764072657, -0.2532775104045868, 0.014666624367237091, 0.5722037553787231, 0.475930780172348, -0.42699477076530457, -0.47211283445358276, 0.739372968673706, 0.6089587807655334, -0.056464243680238724, 0.2671809494495392, 0.15190938115119934, 0.4862730801105499, 0.07434691488742828, 0.48739615082740784, 0.6637750267982483, -0.5472744107246399, 0.1668373942375183, -0.128144308924675, 0.023755894973874092, 0.6106888055801392, 0.1826532483100891, 0.39213359355926514, 0.6468998193740845, 0.6688966155052185, 0.044448405504226685, -1.028450608253479, 0.1434590369462967, -0.12915688753128052, 0.5402405261993408, 0.15102028846740723, 0.36026647686958313, 0.7286593317985535, 0.43575596809387207, -0.06971818953752518, 0.2862469553947449, -0.04734852910041809, 0.22724279761314392, -0.2968149781227112, -0.40312325954437256, -0.4286124110221863, 0.15327775478363037, 1.0175880193710327, 0.312049001455307, 0.003262464189901948, -0.13505007326602936, -0.05031399056315422, 0.8271560668945312, -0.18732167780399323, -0.030257560312747955, -0.2184329777956009, 0.5061086416244507, 0.08186744153499603, 0.41413798928260803, -0.29745012521743774, -0.20542041957378387, -0.782915472984314, -0.14079739153385162, 0.12041499465703964, -0.43181082606315613, -0.46139901876449585, 0.05876928195357323, 0.05176829174160957, 0.5274305939674377, -0.6848136186599731, 0.2631942927837372, -0.732265293598175, -0.09483885020017624, 0.528050422668457, 0.2218233346939087, 0.2400648295879364, -0.12909173965454102, -0.25502634048461914, -0.09561707824468613, -0.2218785285949707, -0.11203489452600479, 0.0392548032104969, -0.3699314594268799, 0.1735188215970993, -0.04036145657300949, -0.21181991696357727, 0.272324800491333, -0.03741202875971794, -0.11447659134864807, -0.2757072448730469, -0.5188289880752563, -0.4020202159881592, -0.17034809291362762, -0.35017627477645874, 0.020895201712846756, 0.5600515007972717, -0.31151872873306274, -0.04148934409022331, -0.2524986267089844, 0.06553951650857925, 0.26393556594848633, -0.17251011729240417, -0.4678017199039459, -0.13231132924556732, 0.1474880427122116, 0.2501791715621948, 0.26865655183792114, -0.11373607069253922, -0.13086538016796112, -0.28777384757995605, 0.5727617144584656, -0.32565438747406006, 0.571153461933136, -0.7305103540420532, 0.4421876072883606, -0.551631510257721, -0.14199553430080414, 0.44165852665901184, 0.1714193969964981, -0.1706533432006836, 0.07507514953613281, 0.0013052962021902204, -0.05912693589925766, 0.29856008291244507, -0.3091062009334564, -0.0670725554227829, 0.19280467927455902, -0.23845960199832916, -0.4371334910392761, 0.20907384157180786, -0.21255886554718018, -0.7885360717773438, -0.15883323550224304, -0.03316304087638855, 0.20387281477451324, 0.10591566562652588, 0.3411678671836853, -0.23735174536705017, -0.24504677951335907, -0.28962960839271545, -0.014445538632571697, -0.648788332939148, -0.11543840169906616, -0.016371333971619606, 0.1411365270614624, 0.13592761754989624, -0.16307368874549866, -0.4210800528526306, -0.13646695017814636, 0.39246752858161926, 0.04110248014330864, 0.30857187509536743, 0.3309705853462219, -0.12300992012023926, -0.4801238477230072, -0.2901005148887634, 0.5684857368469238, -0.12928563356399536, 0.108835369348526, -0.21168053150177002, -0.15075314044952393, -0.1770676225423813, -0.060498613864183426, 0.09211912751197815, -0.8114995956420898, -0.2770936191082001, -0.27436742186546326 ]
Transformation and conjugation permit the passage of DNA through the bacterial membranes and represent dominant modes for the transfer of genetic information between bacterial cells or between bacterial and eukaryotic cells. As such, they are responsible for the spread of fitness-enhancing traits, including antibiotic resistance. Both processes usually involve the recognition of double-stranded DNA, followed by the transfer of single strands. Elaborate molecular machines are responsible for negotiating the passage of macromolecular DNA through the layers of the cell surface. All or nearly all the machine components involved in transformation and conjugation have been identified, and here we present models for their roles in DNA transport.
[ -0.01965867355465889, 0.013762244954705238, -0.010536981746554375, 0.027413638308644295, -0.0072946404106915, -0.037070512771606445, 0.011732099577784538, -0.006368912290781736, -0.016924545168876648, -0.006906948052346706, -0.010688411071896553, 0.014344077557325363, -0.013497481122612953, 0.012232499197125435, -0.003542789723724127, -0.014580353163182735, 0.0062941862270236015, 0.022087600082159042, 0.00628663320094347, -0.0008832634193822742, 0.009276695549488068, -0.00936507061123848, 0.012869151309132576, -0.019062768667936325, 0.009925872087478638, -0.018149234354496002, -0.002205271739512682, -0.007219767197966576, -0.017903979867696762, -0.021300548687577248, -0.0005753689911216497, -0.0026401039212942123, 0.02900075539946556, 0.05620443448424339, -0.0009819561382755637, 0.027537168934941292, -0.0023566139861941338, 0.030590396374464035, 0.0714835673570633, -0.00577919278293848, 0.006010058801621199, -0.014182217419147491, 0.003434553975239396, 0.004532724618911743, -0.007807447575032711, -0.015378165990114212, -0.0033558967988938093, 0.021825745701789856, 0.016304250806570053, 0.009270593523979187, -0.01597614958882332, 0.0025277596432715654, -0.006947013083845377, 0.06258296966552734, -0.00767322164028883, -0.005627388600260019, 0.021160682663321495, 0.006528955884277821, -0.03394785895943642, -0.0007432019338011742, 0.012801248580217361, 0.023906772956252098, 0.010028790682554245, -0.02990882657468319, 0.021750211715698242, -0.06672582030296326, 0.008746007457375526, 0.016501881182193756, -0.009831767529249191, 0.023433402180671692, -0.03836676478385925, 0.005469191819429398, -0.0075883399695158005, 0.011907241307199001, 0.004338179249316454, -0.027437850832939148, -0.00711281131953001, 0.004061637446284294, 0.028941720724105835, 0.01119060255587101, -0.0419367253780365, -0.003349877893924713, 0.021711211651563644, 0.00914125144481659, 0.0010287968907505274, -0.00451243668794632, 0.0023977882228791714, 0.005274584982544184, 0.006748574320226908, -0.023176470771431923, 0.03554409742355347, 0.012918300926685333, -0.016100484877824783, -0.014010388404130936, 0.0025426126085221767, 0.02444656938314438, -0.004530873615294695, -0.04206191003322601, -0.008083350956439972, 0.046200282871723175, -0.024196133017539978, 0.01995975524187088, 0.016394205391407013, 0.017351370304822922, 0.009342579171061516, 0.011070111766457558, 0.02649860270321369, 0.035560429096221924, 0.03044913150370121, 0.0070528811775147915, 0.007953749969601631, 0.014076950028538704, 0.004414253402501345, 0.016114534810185432, 0.030343323945999146, 0.01949947327375412, 0.004793241620063782, 0.011476907879114151, 0.02205066569149494, -0.014740011654794216, 0.0030037201941013336, -0.01504494622349739, 0.000712587614543736, 0.023548539727926254, 0.00845953356474638, 0.009990083985030651, -0.036389268934726715, -0.008181780576705933, 0.026457197964191437, 0.010710880160331726, -0.008272698149085045, 0.0047841984778642654, -0.005417683627456427, -0.014859961345791817, 0.004247845150530338, -0.008774700574576855, -0.046987660229206085, -0.02477090433239937, 0.018144741654396057, 0.004992390517145395, 0.015823647379875183, 0.004012634977698326, 0.005123414099216461, 0.012609908357262611, 0.026685208082199097, -0.012633356265723705, -0.03555465117096901, -0.0007380734896287322, 0.016769761219620705, 0.013658497482538223, -0.03534133732318878, 0.00544147752225399, -0.02284226566553116, -0.021540861576795578, -0.006665878929197788, 0.002743546385318041, -0.007974999025464058, -0.017470117658376694, -0.0014065701980143785, 0.016413655132055283, 0.008217302151024342, -0.012047038413584232, 0.03170044720172882, 0.01118463184684515, -0.005634656175971031, 0.005069165490567684, 0.0008261844050139189, -0.010670142248272896, 0.011525101959705353, 0.014188770204782486, -0.015598203986883163, 0.010013852268457413, -0.0001319593284279108, 0.007965480908751488, 0.01202197466045618, 0.016492187976837158, 0.015818629413843155, 0.007380116730928421, -0.026444047689437866, 0.06652253866195679, -0.01656019315123558, -0.012480693869292736, -0.004575605504214764, 0.019816765561699867, 0.02066574990749359, -0.01582895591855049, -0.006478097289800644, -0.014548871666193008, 0.00201284047216177, -0.006410515401512384, -0.008258692920207977, -0.013487421907484531, -0.029272671788930893, -0.014689482748508453, 0.024143986403942108, 0.004175577312707901, -0.00014204485341906548, 0.0064544230699539185, 0.007372197695076466, 0.00019284896552562714, 0.03610501438379288, -0.00023740995675325394, 0.03465619310736656, 0.03591608628630638, -0.017139658331871033, -0.008361006155610085, 0.007236656732857227, -0.011758396402001381, -0.003442371729761362, 0.006324014160782099, 0.028644133359193802, -0.023189717903733253, -0.02677738666534424, -0.0029372964054346085, -0.024874765425920486, -0.007172930054366589, -0.004524689633399248, -0.015533646568655968, -0.013728102669119835, -0.009858435951173306, 0.006030614022165537, 0.01952259987592697, 0.021268151700496674, 0.01647298038005829, 0.011479781940579414, 0.00008186139166355133, -0.022450413554906845, 0.018530244007706642, -0.013615796342492104, 0.012552997097373009, 0.02222670428454876, -0.0014812098816037178, -0.015388557687401772, 0.04117219150066376, 0.019332267343997955, 0.009194470942020416, 0.015074046328663826, -0.0026519817765802145, 0.020129911601543427, -0.010729788802564144, -0.0261375792324543, -0.006172657944262028, 0.015429280698299408, -0.020076099783182144, -0.01665092632174492, -0.002188539132475853, -0.02192910574376583, 0.01865551993250847, -0.004332943353801966, -0.0002880165120586753, 0.013776466250419617, -0.000019867904484272003, 0.005271683447062969, -0.009847613051533699, 0.024305691942572594, 0.012153803370893002, 0.031523317098617554, 0.008517681621015072, 0.02510380744934082, 0.027695167809724808, -0.002308862516656518, 0.00945369340479374, -0.017100540921092033, -0.022948957979679108, 0.00265354011207819, 0.046066321432590485, 0.0372091606259346, 0.029291220009326935, -0.025071583688259125, 0.0057398295029997826, 0.011259030550718307, -0.00974260177463293, -0.002875944832339883, -0.08044938743114471, -0.014746319502592087, 0.021185845136642456, -0.0276398453861475, 0.011736121959984303, 0.007858051918447018, 0.0066704098135232925, -0.016032470390200615, -0.00686451094225049, 0.013646949082612991, 0.02925916761159897, 0.012740646488964558, -0.017687426880002022, 0.0029753227718174458, -0.003521924838423729, -0.013299437239766121, 0.019354019314050674, -0.028700686991214752, -0.005045210011303425, -0.013391177169978619, -0.018261216580867767, -0.019654657691717148, -0.029515299946069717, -0.013811223208904266, -0.0222259983420372, -0.011421212926506996, -0.0009278655052185059, -0.013836146332323551, 0.010598490945994854, 0.020077276974916458, 0.01754477433860302, -0.02827073633670807, 0.008548259735107422, -0.007888462394475937, -0.00980005320161581, -0.03708649054169655, 0.0001614525099284947, 0.001652768813073635, -0.028327742591500282, 0.051813747733831406, -0.007695832755416632, 0.024450644850730896, 0.018937671557068825, 0.010363953188061714, 0.00704371090978384, 0.0016977707855403423, 0.00478714844211936, -0.0015261489897966385, 0.025863919407129288, -0.0020772083662450314, -0.014604787342250347, -0.0025084095541387796, 0.0001537790521979332, 0.017665566876530647, -0.011586161330342293, -0.007209842558950186, -0.020387522876262665, 0.019721921533346176, -0.01509273611009121, -0.012063665315508842, 0.002205055207014084, 0.009173117578029633, -0.013344462029635906, 0.008859120309352875, 0.02902243472635746, -0.010722769424319267, 0.023338457569479942, -0.00499766506254673, -0.013506261631846428, 0.00994284637272358, 0.021500881761312485, -0.011979172937572002, -0.004512579180300236, -0.00009722402319312096, -0.016623131930828094, -0.006501772440969944, -0.00989232212305069, -0.01408510934561491, 0.005960990209132433, -0.012032594531774521, -0.016272272914648056, 0.024335943162441254, 0.0008300943300127983, -0.003846835345029831, -0.029756342992186546, -0.05225975811481476, 0.011317521333694458, 0.03544248640537262, 0.0120282843708992, -0.017511731013655663, 0.012134922668337822, 0.004455801099538803, -0.0038764518685638905, 0.007483635097742081, -0.02641512081027031, -0.050730250775814056, -0.011961559765040874, -0.008261231705546379, -0.014134978875517845, 0.01114580500870943, -0.03787064924836159, 0.002872216049581766, 0.002608146518468857, -0.014776339754462242, 0.004290491342544556, 0.017435282468795776, -0.007556434255093336, -0.0073085688054561615, 0.02479429543018341, -0.003165137255564332, -0.02678106166422367, 0.016720565035939217, -0.012865936383605003, 0.007952753454446793, 0.018480941653251648, 0.007663370575755835, -0.025963101536035538, -0.017368003726005554, 0.07139738649129868, 0.0006277982611209154, 0.019148007035255432, -0.01879969611763954, -0.01879766210913658, -0.03085043467581272, -0.01379530318081379, 0.010463583283126354, -0.023259835317730904, -0.029214981943368912, 0.013660084456205368, 0.01679283007979393, -0.025202222168445587, -0.00796003919094801, -0.00811589602380991, -0.017290960997343063, -0.020331937819719315, 0.008742219768464565, 0.000213331775739789, 0.0034672366455197334, -0.009493516758084297, -0.03917744755744934, -0.0160992294549942, -0.022456765174865723, -0.019618365913629532, -0.004315693862736225, 0.014792428351938725, -0.013940246775746346, -0.0027281485963612795, 0.01393490843474865, 0.020454587414860725, -0.022007562220096588, -0.0057565923780202866, 0.005501663312315941, 0.016206664964556694, 0.030446074903011322, -0.010268721729516983, 0.005336612928658724, -0.004616542719304562, -0.005038934759795666, 0.0026892274618148804, -0.01247895322740078, 0.002104860031977296, 0.022936951369047165, -0.00739520788192749, 0.0011369895655661821, 0.022066574543714523, -0.005847182124853134, 0.00458199717104435, -0.02863949164748192, -0.026247017085552216, -0.0003729905001819134, 0.013292853720486164, -0.0011087628081440926, 0.006399285979568958, -0.003244456835091114, -0.0035185329616069794, -0.018900873139500618, 0.009427666664123535, -0.007933657616376877, -0.006484764628112316, 0.0280609130859375, 0.026636742055416107, -0.06174851953983307, -0.008791780099272728, -0.019683843478560448, 0.018216369673609734, -0.0073298257775604725, -0.019258592277765274, 0.0006279540248215199, 0.010557851754128933, -0.014473073184490204, -0.009770501405000687, -0.004509160295128822, -0.016926318407058716, -0.004812386818230152, 0.00912649929523468, -0.007987548597157001, -0.009865891188383102, 0.004157811403274536, -0.02408762276172638, -0.006947302259504795, 0.021520838141441345, 0.00616845628246665, 0.004666952881962061, -0.010784533806145191, -0.022407125681638718, -0.07366789877414703, 0.007706225849688053, -0.011587509885430336, -0.009238576516509056, -0.026659436523914337, 0.02058839611709118, -0.017852507531642914, 0.004209612496197224, 0.031101182103157043, -0.005738589446991682, -0.002545170020312071, -0.02316591888666153, 0.021438080817461014, -0.01635587215423584, 0.012995865195989609, 0.006858885288238525, -0.036816176027059555, 0.017974045127630234, -0.04104173928499222, 0.006479678675532341, 0.01246189046651125, 0.015597105957567692, 0.0004665185697376728, -0.004821012262254953, -0.004668053239583969, -0.08022278547286987, -0.016446314752101898, -0.016885967925190926, -0.028351597487926483, -0.009429048746824265, -0.007529920432716608, -0.00107269873842597, 0.010184040293097496, -0.00661514000967145, -0.015667593106627464, -0.006235362961888313, 0.014777556993067265, 0.0023482940159738064, -0.002209545113146305, 0.004660369362682104, -0.0034860968589782715, -0.017466094344854355, 0.013030982576310635, -0.017901577055454254, -0.013996453955769539, 0.0026181205175817013, 0.0065529365092515945, -0.018435370177030563, 0.011710163205862045, -0.004444417543709278, -0.024341285228729248, -0.0028865733183920383, 0.009633509442210197, 0.020205240696668625, 0.008876029402017593, -0.0007261686259880662, -0.009293563663959503, -0.021363358944654465, -0.026696275919675827, 0.017082806676626205, -0.02633088268339634, -0.013519776053726673, 0.006333737634122372, 0.0024113189429044724, -0.000805368646979332, -0.0030711297877132893, 0.019634749740362167, -0.04658900946378708, 0.009385860525071621, -0.004192724358290434, -0.003129270626232028, 0.008835832588374615, -0.0030212029814720154, 0.016537396237254143, -0.007370337378233671, 0.01649470254778862, -0.02204749546945095, -0.023304443806409836, -0.014255376532673836, -0.0002525709569454193, 0.009723203256726265, -0.0014076486695557833, 0.0190621018409729, 0.025537118315696716, 0.0005857811775058508, 0.0027859886176884174, 0.007520011626183987, 0.01368698664009571, 0.07110622525215149, 0.010678536258637905, 0.004512999206781387, 0.006306867115199566, -0.01938284933567047, 0.004989517852663994, -0.01701679453253746, -0.010443493723869324, -0.02265060320496559, 0.000735569279640913, 0.0046651847660541534, -0.019377313554286957, -0.004451798275113106, 0.01782425493001938, 0.013749705627560616, 0.010104741901159286, -0.02157903090119362, 0.014981251209974289, -0.015475496649742126, 0.0011053746566176414, -0.03683144599199295, -0.009533531032502651, 0.00037507270462810993, 0.020346354693174362, 0.016278665512800217, -0.008952377364039421, -0.04610390216112137, -0.02384088933467865, 0.014764748513698578, 0.01143503189086914, -0.002450495259836316, 0.011552717536687851, -0.003148080315440893, -0.00016626040451228619, 0.023392487317323685, -0.004044491797685623, 0.01006980799138546, 0.0018184562213718891, -0.0014305291697382927, -0.010783402249217033, -0.034529685974121094, 0.022502705454826355, 0.0017977622337639332, -0.004700032062828541, 0.0221503134816885, -0.02769218012690544, 0.010886777192354202, 0.006615508813410997, 0.007397295907139778, 0.010486608371138573, -0.0004210593178868294, 0.0007423574570566416, -0.004356858786195517, 0.03787090629339218, -0.002822620328515768, -0.024105869233608246, 0.0019513852894306183, 0.02235957607626915, -0.021311352029442787, 0.021540390327572823, 0.023511525243520737, -0.022374631837010384, -0.051725443452596664, -0.012536684051156044, 0.0042760176584124565, -0.03988177329301834, 0.018500223755836487, -0.013695931062102318, 0.037176020443439484, 0.014350724406540394, 0.022773079574108124, 0.012277602218091488, 0.009806422516703606, -0.0137434471398592, 0.03616838902235031, -0.003330377396196127, 0.01908036693930626, -0.024153340607881546, 0.04108607769012451, 0.002768876263871789, -0.011513489298522472, -0.008413275703787804, -0.028365861624479294, 0.046650663018226624, -0.013694016262888908, -0.016258668154478073, 0.005841498728841543, 0.0008726941887289286, -0.0016067372635006905, 0.010443631559610367, 0.018428077921271324, -0.011867742985486984, 0.0034543871879577637, 0.01598217338323593, 0.004951641894876957, 0.03480955585837364, 0.020443402230739594, -0.003532613394781947, 0.012379052117466927, 0.009459476917982101, 0.008101431652903557, -0.016265669837594032, 0.0031947039533406496, -0.00810176506638527, -0.027677379548549652, -0.008251563645899296, 0.02302088961005211, -0.010237426497042179, -0.015414003282785416, -0.014405408874154091, -0.01781642436981201, -0.01256035640835762, -0.015368982218205929, 0.0214836448431015, -0.006946523208171129, 0.008940014988183975, -0.0249269250780344, 0.03222084790468216, -0.02024603635072708, -0.009579780511558056, -0.003026135265827179, 0.015550416894257069, 0.00798762496560812, 0.03416048735380173, -0.010494220070540905, -0.008566010743379593, -0.012214617803692818, 0.016313545405864716, -0.013129981234669685, -0.008469199761748314, 0.007114501670002937, -0.02299926057457924, 0.008732439950108528, 0.012723391875624657, 0.022922545671463013, -0.005260428413748741, -0.016135361045598984, 0.02890433743596077, -0.012306446209549904, 0.021777905523777008, 0.021451085805892944, -0.009135712869465351, -0.007028908468782902, -0.015619301237165928, 0.007170126773416996, -0.0036538373678922653, 0.009684927761554718, 0.016772136092185974, 0.00895971991121769, 0.0012775305658578873, 0.01565934717655182, 0.013144141063094139, -0.023490171879529953, -0.014150841161608696, -0.0018838746473193169, 0.012963350862264633, 0.005273974500596523, -0.01836041361093521, -0.015788614749908447, 0.015299946069717407, -0.013737833127379417, 0.03544383496046066, -0.00809923280030489, 0.0021307277493178844, -0.0007080108625814319, 0.012868307530879974, -0.04427516460418701, 0.022869886830449104, -0.030269058421254158, 0.003957883454859257, 0.03240412101149559, 0.010740470141172409, 0.003911411389708519, -0.006363369524478912, -0.01910385861992836, -0.012053591199219227, 0.01921796053647995, 0.004384494386613369, -0.014285820536315441, 0.02486075460910797, 0.0010232541244477034, -0.04806925356388092, 0.026317793875932693, -0.010722140781581402, -0.01915457658469677, -0.008811241015791893, -0.017923526465892792, 0.006444143131375313, -0.0026760941836982965, -0.011352341622114182, 0.010022429749369621, -0.0021603298373520374, -0.00396500201895833, 0.0091579370200634, -0.0022907634265720844, -0.020869791507720947, 0.01912780851125717, -0.0014268795493990183, 0.0025349711067974567, 0.014768503606319427, 0.0004523105453699827, -0.017038334161043167 ]
[ 0.29074376821517944, -0.26786983013153076, 0.23656320571899414, 0.15421167016029358, 0.2249028980731964, -0.06721985340118408, 0.26801759004592896, -0.04203489050269127, -0.07105178385972977, -0.9670300483703613, -0.16009970009326935, 0.24303743243217468, -0.42379534244537354, 0.28622984886169434, -0.04958686605095863, 0.10029524564743042, -0.08327370882034302, 0.06290490925312042, -0.11856009811162949, -0.05678413435816765, -0.6300554871559143, -0.10040290653705597, 0.040703848004341125, -0.06585469096899033, 0.17277321219444275, -0.3311271667480469, 0.20365168154239655, -0.38282617926597595, -0.17766690254211426, -0.09084733575582504, 0.23438364267349243, -0.26977717876434326, -0.19566860795021057, -0.2095249444246292, 0.07292648404836655, -0.30027419328689575, -0.4019663333892822, -0.057755205780267715, -0.11261685192584991, -0.1872553676366806, -0.33530548214912415, -0.02407650835812092, 0.08611021190881729, -0.009241795167326927, -0.3511635363101959, -0.4611431360244751, -0.9947571158409119, 0.8338872790336609, -0.8725023865699768, 0.2048223912715912, -0.26157641410827637, -0.41470593214035034, 0.46137213706970215, 0.8550960421562195, 0.16120576858520508, 0.5303058624267578, -0.45472225546836853, 0.2238282859325409, 0.046661753207445145, -0.9883511066436768, 0.13988108932971954, 0.30395933985710144, -0.36759042739868164, 0.24646449089050293, 0.4942604601383209, 0.21929800510406494, 0.14031006395816803, -0.12703117728233337, -0.46313098073005676, -0.8087928891181946, 0.4140101969242096, -0.004659533035010099, 0.03146275132894516, 0.48934561014175415, 0.06219349801540375, -0.2224397510290146, -0.14286436140537262, -0.49232444167137146, 0.3015420138835907, -0.15557967126369476, -0.5651809573173523, 0.21815361082553864, -0.26293331384658813, -0.045896559953689575, 0.6939702033996582, 0.132137730717659, -0.24235570430755615, 0.6621529459953308, -0.7494348883628845, -0.24550408124923706, 0.08331084996461868, -0.09814202040433884, 0.005376635584980249, 0.040903761982917786, 0.3904869854450226, 0.134474977850914, 0.13141174614429474, -0.20428462326526642, 0.24127662181854248, 0.06920132786035538, -0.6046648025512695, -0.19499357044696808, 0.2565165162086487, -0.5027470588684082, -0.1423044502735138, -0.17454686760902405, -0.4648129642009735, -0.5194331407546997, 0.3735652267932892, 0.20909999310970306, -0.356594979763031, -0.18002945184707642, -0.18382391333580017, -0.14664189517498016, -0.34423789381980896, -0.03198840469121933, -0.1407816857099533, -0.12600238621234894, -0.2419222742319107, 0.0565003976225853, -0.14031071960926056, 0.8845961093902588, 0.1655125468969345, 0.10715345293283463, -0.07903794199228287, -0.41051116585731506, 0.028520885854959488, 0.3667737543582916, -0.8247240781784058, 0.04670380428433418, 0.4036487638950348, 1.0095678567886353, -0.16624347865581512, 0.35843485593795776, 0.08359034359455109, -0.5917779207229614, 0.3110657036304474, 0.2424488067626953, 0.33347418904304504, -0.05013270676136017, -0.6002385020256042, -0.26478636264801025, 0.10357274115085602, -0.002103046514093876, -0.044083721935749054, -0.625372052192688, -0.054180826991796494, -0.5512077808380127, -0.4656255543231964, -0.27088579535484314, -0.06455940753221512, 0.13246387243270874, -0.20205745100975037, -0.13467644155025482, 0.10643428564071655, 0.5627435445785522, 0.3963870406150818, 0.2773570716381073, 0.06452637910842896, 0.22682443261146545, 0.10794135928153992, -0.04850847274065018, -0.5510276556015015, -0.07234670221805573, 0.2979201078414917, -0.23892982304096222, 0.598613977432251, 1.0897160768508911, -0.06777157634496689, -0.3106224238872528, 0.164892315864563, -0.20471391081809998, 0.32074281573295593, -0.5860153436660767, -0.26830148696899414, 0.08890263736248016, 0.05798975005745888, -0.18435990810394287, 0.4232937693595886, -0.37984466552734375, -0.6230363249778748, 0.35808631777763367, -0.09706738591194153, -0.12024301290512085, 0.08144088089466095, -0.4537833034992218, 0.3020499646663666, -0.09696928411722183, -0.5879140496253967, 0.28271955251693726, -0.14848245680332184, -0.031036430969834328, 0.0016323653981089592, -0.8466657996177673, 0.9281424283981323, 0.35302242636680603, -0.6752498745918274, 1.3588918447494507, -0.3697473108768463, -0.2948101758956909, -0.4125523269176483, 0.40965577960014343, 0.454784631729126, -0.8093212842941284, -0.05815606564283371, 0.005303040146827698, 0.46583548188209534, -0.11571352183818817, 0.33601081371307373, 0.08874966204166412, 0.3947552442550659, -0.14999839663505554, 0.0503755584359169, -0.2240268737077713, 0.3054778575897217, -0.2180168181657791, -0.5870352983474731, 0.00670230807736516, -0.012978395447134972, 0.032994527369737625, 0.6969925761222839, -0.5743640661239624, -0.0878104418516159, 0.750638484954834, 0.003372340463101864, 0.5956271290779114, 0.667538046836853, 0.3613167405128479, 0.6308858394622803, 0.18238858878612518, 0.3214183747768402, -0.5022702813148499, 0.32326534390449524, -0.340666800737381, -0.14770689606666565, 0.21644844114780426, 0.5365209579467773, 0.05521675944328308, 0.23120830953121185, -0.05141140893101692, -0.0028864957857877016, 0.261326402425766, -0.5562669038772583, -0.21088814735412598, 0.040453050285577774, -0.034040939062833786, -0.18852926790714264, -0.27182385325431824, -0.09068018198013306, -0.15661270916461945, -0.008698764257133007, 0.3484856188297272, 0.19264857470989227, -0.6889296174049377, 0.7830876708030701, -0.5620168447494507, -0.14147156476974487, -0.005789910908788443, 0.4519230127334595, 0.011473757214844227, -0.050161074846982956, -0.35317927598953247, -0.3751817047595978, 0.11413438618183136, -0.4722779393196106, -0.2690013647079468, -0.5224193930625916, -0.21807043254375458, 0.8250226974487305, 0.9328780174255371, 0.6260294914245605, 0.31501033902168274, -0.48894521594047546, -0.2077418714761734, -0.34589460492134094, -0.43708568811416626, 0.44184061884880066, 0.07798268646001816, -0.010961228981614113, -0.41085875034332275, -0.28324905037879944, 0.06905513256788254, 0.27068251371383667, -0.36399659514427185, -0.3291550576686859, -0.48333504796028137, -0.13267779350280762, -0.14479990303516388, -0.384990930557251, 0.07917696982622147, -0.4450608491897583, 0.3374840021133423, -0.3056957423686981, 0.005761404521763325, 0.04704083874821663, -0.018427670001983643, -0.3161579966545105, 0.0058319587260484695, 0.4755922257900238, -0.08861877769231796, -0.05036323517560959, -0.035396743565797806, -0.11667513102293015, -0.025567712262272835, -0.12978209555149078, -0.2564341723918915, -0.04329892620444298, 0.2782326340675354, -6.026041507720947, -0.16944628953933716, -0.12908463180065155, 0.1368383765220642, 0.24691440165042877, -0.31100383400917053, 0.8674625158309937, 0.18455886840820312, 0.17299553751945496, -0.07321739196777344, 0.0393417589366436, 0.3281230926513672, -0.2647304832935333, 0.2853659391403198, -0.059500034898519516, 0.1928611844778061, 0.24564169347286224, 0.07110369950532913, 0.12566886842250824, 0.3274116516113281, -0.19711355865001678, -0.34784165024757385, 0.2121766358613968, 0.428784042596817, 0.03037884458899498, -0.6806804537773132, -0.909385621547699, -0.11220882833003998, -0.0412277989089489, 0.07060226798057556, -0.35071349143981934, -0.1919950395822525, 0.60661780834198, 0.02964208275079727, 0.5628650188446045, -0.19015710055828094, 0.26521560549736023, -0.210381880402565, 0.008684185333549976, -0.5721232891082764, 0.4765765070915222, 0.5794865489006042, -0.006523217540234327, -0.5303569436073303, 0.3344899117946625, -0.4834670126438141, 0.1144755408167839, 0.11371330916881561, 0.03260042890906334, 1.0074607133865356, -0.15443676710128784, 0.11506631225347519, 0.6971001625061035, -0.10503149032592773, 0.3405264616012573, -0.26339003443717957, -0.06433027982711792, -0.4810466468334198, -0.13737152516841888, -0.25361523032188416, -0.07386399060487747, -0.5973114371299744, -0.11528056859970093, -0.5942325592041016, 0.33869853615760803, 0.41073840856552124, -0.7658856511116028, -0.43699318170547485, 0.5675398111343384, 0.4147185981273651, -0.3592514097690582, 0.3573667109012604, 0.12742313742637634, -0.3604196310043335, 0.5687638521194458, -0.27996549010276794, -0.027905408293008804, -0.3689137101173401, 0.5364057421684265, 0.0566490963101387, -0.2441878318786621, -0.2101459503173828, -0.49780943989753723, -0.23282699286937714, 0.1929449588060379, -0.5672289729118347, -0.3675647974014282, -0.23662926256656647, -0.596668004989624, 0.06937538087368011, 0.975543200969696, 0.206308975815773, 0.25373274087905884, -0.0038262533489614725, 0.3609432578086853, 0.013121895492076874, -0.32159683108329773, 0.647797167301178, 0.2441108077764511, -0.3170870244503021, 0.45117297768592834, -0.11064907163381577, -0.219424769282341, -0.1964448094367981, 0.050078365951776505, 0.2243025004863739, -0.44342514872550964, 0.4030381441116333, 0.35751834511756897, -0.2400278002023697, -0.6095365285873413, 0.3882991075515747, -0.21432821452617645, -0.12832237780094147, 0.13299109041690826, 0.1465396136045456, -0.22821766138076782, 0.20770184695720673, 1.1578820943832397, -0.3191116750240326, 0.3242780268192291, 0.8006737232208252, -0.6601271033287048, 0.4287393093109131, 0.07619763165712357, -0.09647057205438614, 0.0742405354976654, 0.5841696858406067, 0.18346497416496277, -0.3664338290691376, 0.29295411705970764, 0.3717430531978607, -0.33121564984321594, -0.563949465751648, 0.2479172796010971, 0.1515747755765915, -0.1442786455154419, 0.0792880728840828, -0.6650835871696472, -0.5804523825645447, 0.4894571602344513, -0.5573664307594299, 0.2269713282585144, -0.2709046006202698, 0.09695620089769363, 0.26118308305740356, -0.15962018072605133, 0.21499180793762207, 0.001571596716530621, 0.24215106666088104, 0.16305355727672577, -0.41749194264411926, -0.13146978616714478, -0.21936173737049103, -0.3612207770347595, -0.11603913456201553, 0.4364635646343231, -0.011777576990425587, 0.7643526792526245, -0.49915462732315063, 0.2113509327173233, 0.13343872129917145, -0.5143561363220215, 0.2385154515504837, -0.6200092434883118, 0.438212513923645, -0.6360689401626587, -0.3559061586856842, -0.4250355660915375, 0.09559179842472076, -0.6717199683189392, -0.024758676066994667, -0.6841771006584167, -0.10505404323339462, -0.3000735938549042, -0.075689397752285, 0.02838614024221897, 0.26660817861557007, -0.1938943713903427, -0.1336827427148819, 0.4635753929615021, -0.7318453788757324, 0.03493139520287514, 0.04062448814511299, 0.43583670258522034, -0.44021254777908325, 0.2666056752204895, 0.28025171160697937, -0.23330853879451752, -0.24146583676338196, 0.35566815733909607, 0.6533739566802979, 0.19362205266952515, -0.7158121466636658, -0.15010543167591095, -0.032931990921497345, -0.3595165014266968, 0.9165222644805908, 0.07890979945659637, -0.36021479964256287, 0.18418817222118378, 0.5211108922958374, -0.604214072227478, 0.27724066376686096, 0.14274239540100098, 0.24216322600841522, -0.24010120332241058, -0.13765878975391388, 0.5258094072341919, -0.4354344308376312, -0.2886115610599518, -0.12183883041143417, 0.11276356130838394, 0.28539708256721497, -0.4394659399986267, 0.11232324689626694, 0.06282135099172592, -0.015916993841528893, 0.20309096574783325, 0.3387793004512787, 0.38286516070365906, 0.12161482870578766, 0.03603123873472214, 0.2527613937854767, -0.16563697159290314, 0.33635759353637695, 0.13914754986763, -0.3252781629562378, -0.20844826102256775, 0.3688172996044159, 0.33226436376571655, -0.22571039199829102, -0.23221376538276672, -0.12227657437324524, 0.028544316068291664, -0.2910802662372589, 0.2429710477590561, 0.18248331546783447, 0.129128560423851, -0.16432711482048035, 0.9910799264907837, 0.39330556988716125, -0.40703338384628296, 0.2767263352870941, 0.12535952031612396, 1.1307737827301025, 0.32867172360420227, -0.7294120192527771, -0.45922818779945374, -0.28893113136291504, 0.1357933133840561, -0.043358925729990005, -0.06363649666309357, 0.13237068057060242, 0.515819787979126, 0.4064818024635315, -0.1044980064034462, 0.006572802551090717, 0.10920197516679764, 0.25160565972328186, 0.10220020264387131, 0.030154215171933174, -0.4537028968334198, -0.36764830350875854, 0.26238155364990234, -0.08796116709709167, -0.3135773241519928, -0.050657257437705994, 0.03655802831053734, 0.17915454506874084, 0.1958230435848236, -0.005730142816901207, 0.3041689693927765, 0.4422355890274048, 0.08933349698781967, 0.4953291714191437, -0.18727466464042664, 0.25302931666374207, -0.17850317060947418, -0.14365851879119873, -0.3158644735813141, -0.3361039161682129, 0.1386486142873764, -0.03980769217014313, 0.10799609869718552, -0.4455256760120392, 0.3503926396369934, -0.3072197735309601, 0.04035957157611847, -0.24551928043365479, 0.07374731451272964, -0.14055931568145752, -0.07039009779691696, -0.0640220195055008, 0.18036171793937683, 0.11348100751638412, 0.24109399318695068, 0.6068719625473022, -0.3197861909866333, -0.36266809701919556, -0.2439306378364563, 0.13133220374584198, 0.40520983934402466, -1.0907989740371704, 0.3952900469303131, 0.3370898962020874, 0.49831506609916687, -0.1558336764574051, -0.42456260323524475, -0.03823471441864967, 0.48697343468666077, 0.1010652631521225, -0.029424946755170822, -0.014371445402503014, -0.033183563500642776, 0.24593763053417206, 0.16287320852279663, -0.5137841105461121, -0.07283283770084381, -0.0982932522892952, 0.4168258011341095, 0.33811095356941223, -0.26777520775794983, -0.404753178358078, 0.18269041180610657, 0.4511081576347351, 0.06893717497587204, -0.2701593339443207, -0.5045618414878845, 0.39256206154823303, 0.8169973492622375, 0.3540169298648834, -0.4120456278324127, 0.21514149010181427, 0.1796024739742279, -0.28928324580192566, -0.3541449010372162, 0.16717199981212616, 0.11482449620962143, 0.5234009623527527, 0.24996043741703033, 0.6182742714881897, -0.6768191456794739, 0.029154352843761444, 0.30468103289604187, 0.22836384177207947, 0.15406417846679688, 0.33111903071403503, -0.16037656366825104, 0.44040966033935547, 0.6289211511611938, -0.7739681601524353, 0.06209571659564972, 0.28268685936927795, -0.35788002610206604, -0.46310508251190186, 0.6296084523200989, -0.2745949625968933, 0.17248418927192688, 0.17981857061386108, 0.02352946251630783, 0.7383793592453003, 0.14336049556732178, -0.2580793797969818, 0.014121166430413723, -0.12270291894674301, 0.6252636313438416, -0.3997843265533447, 0.1940983682870865, 0.05720442906022072, 0.1786278784275055, 0.536241352558136, -0.39856579899787903, 0.08228331804275513, -0.028175976127386093, -0.39620041847229004, 0.06165657192468643, 0.6761199235916138, -0.05065174773335457, -0.043495308607816696, -0.5695769786834717, 0.017463810741901398, -0.18928056955337524, -0.5275870561599731, -0.258685439825058, 0.09007569402456284, -0.02385927177965641, -0.27322468161582947, -0.0837172269821167, 0.24851976335048676, 0.5243374109268188, -0.8905789852142334, 0.028491396456956863, 0.1922554224729538, 0.023201370611786842, 0.1076715961098671, -0.037231769412755966, 0.6010217070579529, 0.267143189907074, -0.09021030366420746, -0.1526993066072464, 0.6231945753097534, 0.09064341336488724, -0.06515683233737946, -0.5115501880645752, 0.4163471460342407, -0.6373715996742249, -0.41303151845932007, -0.2256811261177063, 0.0736372247338295, 1.167122721672058, -0.0318908728659153, -0.28143933415412903, 0.10198165476322174, 0.16398924589157104, 0.3752114474773407, -0.3555862307548523, -0.3692619204521179, 0.45598697662353516, -0.23302379250526428, 0.1331174075603485, -0.37283989787101746, 0.4944218695163727, -0.0871281772851944, -0.0701093077659607, -0.11959201097488403, 0.389642596244812, 0.8022717237472534, -0.5816481113433838, 0.8076151609420776, 0.05040332302451134, 0.3834993243217468, -0.23697637021541595, 0.42055025696754456, -0.34944403171539307, -0.16878893971443176, -0.7072604894638062, 0.36887127161026, 0.25925323367118835, -0.2892002761363983, 0.3342503607273102, 0.2612972855567932, 0.20684055984020233, 0.09595854580402374, -0.2142162173986435, -0.3798518478870392, 0.13970962166786194, 0.13525278866291046, -0.6624588966369629, -0.24299786984920502, 0.1598246991634369, -0.42212364077568054, -0.03060459904372692, 0.2845229506492615, -0.16678981482982635, -0.007732271682471037, -0.04991655796766281, -0.42340168356895447, -0.25681012868881226, 0.1968279480934143 ]
In the mammalian brain, astrocytes modulate neuronal function, in part, by synchronizing neuronal firing and coordinating synaptic networks. Little, however, is known about how this is accomplished from a structural standpoint. To investigate the structural basis of astrocyte-mediated neuronal synchrony and synaptic coordination, the three-dimensional relationships between cortical astrocytes and neurons was investigated. Using a transgenic and viral approach to label astrocytes with enhanced green fluorescent protein, we performed a three-dimensional reconstruction of astrocytes from tissue sections or live animals in vivo. We found that cortical astrocytes occupy nonoverlapping territories similar to those described in the hippocampus. Using immunofluorescence labeling of neuronal somata, a single astrocyte enwraps on average four neuronal somata with an upper limit of eight. Single-neuron dye-fills allowed us to estimate that one astrocyte contacts 300-600 neuronal dendrites. Together with the recent findings showing that glial Ca2+ signaling is restricted to individual astrocytes in vivo, and that Ca2+ signaling leads to gliotransmission, we propose the concept of functional islands of synapses in which groups of synapses confined within the boundaries of an individual astrocyte are modulated by the gliotransmitter environment controlled by that astrocyte. Our description offers a new structurally based conceptual framework to evaluate functional data involving interactions between neurons and astrocytes in the mammalian brain.
[ -0.009377844631671906, 0.005431448109447956, 0.0035837215837091208, 0.02018754929304123, 0.019859671592712402, -0.021464424207806587, 0.0097606610506773, -0.015664001926779747, -0.018224788829684258, 0.017660312354564667, -0.010088793002068996, 0.016526691615581512, -0.005390900652855635, 0.011009025387465954, -0.009266266599297523, 0.004501574672758579, -0.01908894255757332, 0.01095476932823658, 0.0015085884369909763, 0.022990811616182327, 0.0016399079468101263, -0.009404513984918594, 0.010648141615092754, 0.0009644085075706244, 0.00962587259709835, 0.005534978583455086, -0.003544737584888935, -0.02624601125717163, 0.00889655388891697, 0.012231754139065742, -0.0066474732011556625, -0.00021117611322551966, 0.012896650470793247, -0.013722775503993034, -0.004407188389450312, -0.007227045018225908, -0.003803165629506111, 0.020212475210428238, -0.0015568094095215201, -0.0013902506325393915, 0.015354413539171219, -0.006992636248469353, 0.007086262106895447, 0.013137122616171837, -0.0071348827332258224, 0.01379882451146841, -0.001704538008198142, 0.011917447671294212, -0.0236506350338459, -0.0003035325789824128, -0.003955789376050234, -0.015372938476502895, 0.003942000679671764, 0.024691957980394363, -0.00642387755215168, -0.001208605244755745, 0.01920371502637863, -0.03947478532791138, 0.009478550404310226, 0.003956818487495184, -0.009984818287193775, 0.006673688068985939, 0.013576110824942589, 0.0004472690634429455, 0.022392047569155693, -0.06705182790756226, 0.0007704340387135744, 0.0003636216279119253, -0.0021879214327782393, 0.013561716303229332, -0.0022470694966614246, 0.014757083728909492, -0.019521282985806465, 0.000059512909501791, 0.028887035325169563, -0.02198381908237934, -0.021660692989826202, -0.01741950958967209, -0.008518501184880733, 0.02785114385187626, -0.0020514363422989845, -0.010685356333851814, 0.00006350153125822544, 0.0016975200269371271, 0.04235393553972244, 0.0014601461589336395, -0.020803511142730713, 0.012959230691194534, 0.017387842759490013, 0.021547529846429825, 0.032450463622808456, -0.005233281292021275, -0.01635289192199707, 0.01408421341329813, 0.007665014360100031, 0.011124368757009506, -0.032149989157915115, -0.00468172412365675, 0.014365628361701965, -0.006057340651750565, -0.007550785783678293, 0.025897812098264694, 0.022517111152410507, -0.012779368087649345, 0.0050780801102519035, 0.008281240239739418, 0.030307956039905548, -0.011175757274031639, -0.021496571600437164, 0.006618979852646589, 0.02813735045492649, -0.025724656879901886, -0.037642624229192734, 0.024654658511281013, 0.03781641647219658, 0.014508978463709354, -0.018186185508966446, 0.017854077741503716, 0.010906174778938293, 0.004976367577910423, 0.036016810685396194, 0.01660185493528843, 0.0009772058110684156, -0.0016483725048601627, 0.006747450679540634, 0.010305870324373245, -0.006948324851691723, 0.00211549480445683, 0.02960980497300625, 0.013380756601691246, -0.00649407459422946, 0.00656729843467474, 0.0023487394209951162, 0.001159890554845333, 0.019517822191119194, -0.0039008783642202616, -0.010541963391005993, -0.016755687072873116, 0.011204429902136326, -0.020234830677509308, 0.013078693300485611, 0.010638748295605183, 0.008735304698348045, 0.01973336562514305, -0.00929303653538227, 0.00043461722088977695, -0.014149922877550125, 0.016548078507184982, -0.013650981709361076, -0.02153134159743786, 0.003195858560502529, -0.02164151892066002, -0.0075156306847929955, -0.02131911739706993, -0.004423035308718681, 0.0020352997817099094, -0.0069928294979035854, -0.04138476774096489, -0.011233425699174404, -0.0189913772046566, -0.014575682580471039, -0.005852776113897562, -0.0023603644222021103, 0.010213996283710003, 0.007575751282274723, 0.029184315353631973, -0.017543405294418335, -0.009456176310777664, -0.04817713052034378, 0.002928253496065736, -0.0025134077295660973, 0.003806327935308218, 0.011786050163209438, 0.01450389251112938, -0.005299173295497894, 0.010509595274925232, 0.020052537322044373, 0.007484244182705879, -0.01961652934551239, 0.06681368499994278, 0.018885841593146324, 0.044160060584545135, 0.014085318893194199, 0.010733801871538162, 0.001372481812722981, -0.0297711081802845, 0.0011910246685147285, -0.004238883964717388, 0.006948946043848991, -0.005154843907803297, 0.012882011942565441, -0.038428809493780136, -0.018542960286140442, 0.006334288511425257, 0.003949303179979324, 0.003304493147879839, 0.0340634323656559, -0.002145904116332531, -0.0045075854286551476, -0.013580497354269028, -0.017837218940258026, 0.007452366873621941, 0.018437163904309273, -0.018613960593938828, 0.012391000986099243, -0.01257998589426279, 0.01044013723731041, -0.02580747753381729, -0.004561372101306915, -0.0028162160888314247, 0.0243935976177454, -0.00140958814881742, 0.0032657980918884277, -0.011795415543019772, 0.04333004355430603, -0.01807045377790928, 0.0038688741624355316, 0.005606452934443951, 0.004075638949871063, -0.01469440758228302, 0.001704565598629415, 0.026306193321943283, 0.01621171645820141, -0.022534167394042015, 0.014951921068131924, 0.004181982018053532, 0.0077001238241791725, 0.012955032289028168, 0.009669638238847256, 0.003231868613511324, -0.008240124210715294, -0.015546273440122604, -0.01122722215950489, 0.01154083851724863, 0.02625783160328865, -0.03112269751727581, 0.012595280073583126, -0.004222015850245953, 0.013510243967175484, -0.010829677805304527, -0.010900513269007206, -0.006822487339377403, 0.06024645268917084, -0.02739977277815342, 0.01735132746398449, 0.04012557119131088, 0.012904305942356586, -0.008417483419179916, 0.02611912414431572, -0.032256532460451126, 0.009291972033679485, 0.006329153198748827, -0.0031365458853542805, 0.01335516944527626, 0.0033432396594434977, -0.0020106537267565727, 0.03778461739420891, 0.01927199214696884, 0.02442675642669201, 0.0027122502215206623, 0.0005685747601091862, 0.0037402554880827665, 0.02129313349723816, 0.016422800719738007, -0.017571821808815002, 0.010006820783019066, 0.01472391001880169, -0.005019816569983959, -0.035700030624866486, -0.01806895062327385, 0.0033772129099816084, -0.006774361245334148, 0.006050383672118187, -0.08099731802940369, -0.014118227176368237, -0.023060498759150505, 0.03606510907411575, 0.01030003186315298, -0.0072535802610218525, 0.016992641612887383, -0.007847652770578861, -0.011605297215282917, 0.0012864882592111826, 0.011932427063584328, 0.017469383776187897, -0.01435412559658289, 0.008300278335809708, 0.03566066920757294, -0.005967509932816029, 0.015593179501593113, 0.0018566733924672008, -0.013168679550290108, -0.018749449402093887, 0.03194784000515938, -0.020508382469415665, -0.03286435455083847, -0.0018907515332102776, -0.005884024780243635, 0.006159551907330751, -0.003570358268916607, -0.013369889929890633, -0.02458260767161846, 0.010402497835457325, -0.014827960170805454, 0.012093713507056236, -0.005530554801225662, 0.020293336361646652, 0.008543184027075768, 0.027249334380030632, 0.01825323887169361, 0.011652684770524502, -0.022963564842939377, 0.0021674148738384247, 0.01059051975607872, 0.017778683453798294, -0.006296089850366116, 0.01214241050183773, 0.003644120180979371, -0.0016179969534277916, 0.027249690145254135, -0.02182755246758461, 0.017578404396772385, -0.003937325440347195, 0.0053143855184316635, -0.0030131954699754715, 0.012431701645255089, 0.007993767037987709, -0.011442979797720909, 0.013545182533562183, 0.003580973017960787, 0.0411602146923542, -0.011396676301956177, 0.006751018110662699, 0.0022953576408326626, -0.03513672575354576, -0.008488202467560768, 0.030354207381606102, -0.007121756672859192, -0.02770311012864113, 0.026046980172395706, 0.009701918810606003, -0.007073945365846157, -0.009601074270904064, -0.018480686470866203, 0.014291441068053246, -0.0036848033778369427, 0.0010959309292957187, -0.010366618633270264, -0.009141108021140099, -0.009171904996037483, -0.0037086319644004107, -0.03868173062801361, -0.041126273572444916, -0.01763453520834446, -0.0036363350227475166, -0.007804583758115768, -0.01779351942241192, -0.023918773978948593, -0.0048592970706522465, 0.002479954157024622, 0.018286002799868584, 0.014181630685925484, -0.021593131124973297, -0.006954874377697706, -0.012684177607297897, -0.02101469784975052, 0.004859798587858677, -0.0037872320972383022, -0.0032840752974152565, -0.009930621832609177, 0.01956060901284218, -0.004126228392124176, 0.00991484709084034, -0.018369803205132484, 0.011603886261582375, 0.013889143243432045, -0.006077039986848831, -0.019344346597790718, 0.012009061872959137, -0.002285595517605543, -0.040042679756879807, 0.008443646132946014, -0.007415071129798889, 0.004265185911208391, 0.00591660151258111, -0.0069994693621993065, 0.03622894734144211, 0.0031614608597010374, 0.018612032756209373, -0.018689557909965515, 0.005708098411560059, 0.07193903625011444, 0.029062122106552124, -0.0016969143180176616, -0.007067427039146423, -0.0019040745683014393, -0.020818814635276794, -0.02374531328678131, 0.02358144149184227, -0.046309009194374084, 0.013624006882309914, 0.012489402666687965, -0.02199901081621647, -0.022563086822628975, 0.018011514097452164, -0.024663487449288368, -0.014529762789607048, 0.0074426522478461266, -0.002250858349725604, 0.0024771280586719513, 0.012200083583593369, -0.01519786100834608, -0.018837910145521164, -0.007030666805803776, -0.020374968647956848, -0.00982743501663208, 0.010834593325853348, 0.038327962160110474, -0.013689905405044556, 0.0007517097983509302, 0.004649425856769085, -0.01761297881603241, 0.004062682390213013, -0.0035624136216938496, 0.012829245068132877, 0.020449761301279068, -0.017640432342886925, -0.00022678892128169537, -0.007989226840436459, -0.009312442503869534, -0.0033499570563435555, -0.009749221615493298, -0.009749430231750011, -0.0065704407170414925, 0.03222474828362465, -0.00797961000353098, -0.012505246326327324, 0.007311703637242317, -0.006352398544549942, 0.0010108237620443106, -0.0010573803447186947, -0.02070126309990883, -0.00939900241792202, 0.005441499873995781, 0.03551724553108215, 0.029301099479198456, -0.013711509294807911, 0.04656967893242836, -0.003113701706752181, -0.008320126682519913, -0.03397650271654129, 0.005043107084929943, 0.01336761936545372, 0.0003012777306139469, 0.002828001044690609, -0.005803657695651054, -0.014399638399481773, 0.009466415271162987, 0.015335272997617722, 0.004020389169454575, 0.01488383486866951, -0.01426015980541706, 0.0012704068794846535, 0.003558410331606865, -0.005468219053000212, -0.011989496648311615, -0.019915428012609482, -0.007305879611521959, -0.004469249397516251, 0.02687523141503334, -0.009044427424669266, 0.019242778420448303, -0.01517195999622345, 0.03873030096292496, 0.00431226147338748, -0.012825531885027885, 0.0015086811035871506, -0.018533263355493546, -0.07476459443569183, -0.008005933836102486, -0.012448575347661972, -0.005723031237721443, -0.015028802677989006, -0.020351998507976532, -0.01314637716859579, -0.0083875497803092, -0.01612827554345131, -0.0024010513443499804, 0.007569688372313976, 0.025940855965018272, 0.006569997873157263, -0.005450046621263027, 0.010703480802476406, -0.007809988688677549, -0.036286864429712296, 0.013327600434422493, -0.026584960520267487, -0.0009009800851345062, -0.007067493628710508, 0.029002917930483818, -0.005158944986760616, -0.0005191974341869354, 0.012425714172422886, -0.08088621497154236, -0.012337898835539818, -0.0000046825152821838856, 0.004030052572488785, -0.01156523171812296, 0.02114715427160263, -0.006797610782086849, -0.033097729086875916, -0.023694781586527824, -0.019236372783780098, 0.010303832590579987, 0.012525195255875587, -0.018489476293325424, -0.007225604262202978, -0.005063885822892189, -0.007114029489457607, 0.008697282522916794, -0.01522771269083023, 0.010880360379815102, -0.024675263091921806, -0.0019295644015073776, 0.017885036766529083, -0.020251546055078506, -0.006912456825375557, -0.0118191447108984, -0.013507288880646229, -0.006283826194703579, 0.012169204652309418, 0.005916854366660118, 0.0011250958777964115, -0.00006736256182193756, 0.010500826872885227, -0.013735528104007244, -0.010043439455330372, -0.041759319603443146, -0.014675214886665344, -0.02041035145521164, 0.001681576482951641, -0.022949982434511185, -0.00799984484910965, -0.0059113227762281895, 0.012002680450677872, 0.00417714286595583, 0.0020077782683074474, -0.034200236201286316, -0.006893565878272057, 0.005349296145141125, 0.004835441708564758, 0.006322575267404318, -0.014801351353526115, 0.008383313193917274, 0.009239672683179379, 0.006365081295371056, -0.0029508129227906466, 0.020329680293798447, -0.0010248785838484764, 0.01071981806308031, 0.016611818224191666, 0.005135484971106052, 0.009863493964076042, -0.004015868064016104, 0.007517054211348295, -0.0037585666868835688, 0.07150067389011383, 0.007195973768830299, 0.021930500864982605, -0.0007119908113963902, 0.0030972203239798546, 0.001704686088487506, -0.03485213965177536, -0.0007011163979768753, 0.030675789341330528, -0.03212173283100128, -0.018300632014870644, -0.004093993455171585, 0.020394641906023026, 0.008648641407489777, -0.017922021448612213, 0.022316236048936844, -0.022434785962104797, 0.014630036428570747, -0.03040868602693081, 0.006602501962333918, -0.004055153578519821, 0.023978732526302338, 0.005065801553428173, 0.012165560387074947, -0.014738144353032112, 0.014054378494620323, 0.00571441650390625, 0.015399270690977573, -0.02479430101811886, -0.0216105654835701, -0.026029979810118675, 0.005329789128154516, -0.004299637861549854, -0.007274184376001358, 0.02687227725982666, 0.016536913812160492, -0.0138711491599679, 0.0011479955865070224, -0.022594619542360306, -0.013327691704034805, 0.004290631040930748, 0.02289019152522087, 0.00582212395966053, -0.02648480236530304, -0.0010753991082310677, 0.015870150178670883, 0.010822121053934097, -0.021964367479085922, 0.012640097178518772, 0.009902091696858406, -0.0006380877457559109, 0.008016156032681465, 0.006852304562926292, -0.013787109404802322, 0.025675617158412933, -0.010922480374574661, -0.011917568743228912, 0.02382698282599449, -0.0020378115586936474, -0.02534695714712143, 0.003961660899221897, -0.015241870656609535, -0.006182966288179159, -0.015508201904594898, 0.011846352368593216, 0.018180936574935913, 0.01975366845726967, -0.015419865027070045, -0.0003067092038691044, 0.012379088439047337, -0.014787174761295319, -0.004763736855238676, 0.004041402600705624, 0.019469326362013817, -0.002183461096137762, 0.002295935992151499, -0.02981414645910263, 0.0016555520705878735, 0.025779934599995613, 0.025472700595855713, -0.010717018507421017, 0.011410699225962162, -0.011857918463647366, 0.03090256080031395, 0.020164446905255318, 0.03127678856253624, -0.005646992940455675, 0.0053726620972156525, -0.0034156525507569313, 0.01692652702331543, -0.005559083074331284, -0.007535683922469616, 0.0032437345944344997, 0.0035536980722099543, 0.007106813136488199, 0.03457771614193916, 0.009770608507096767, 0.007803388871252537, -0.007083187811076641, 0.01019363198429346, 0.012961551547050476, -0.013230675831437111, -0.013109109364449978, 0.009383375756442547, -0.010994162410497665, -0.008183804340660572, 0.030941952019929886, 0.015864809975028038, 0.024931252002716064, 0.009746302850544453, 0.023155320435762405, -0.03011881187558174, 0.04279572516679764, 0.004259063396602869, -0.022631846368312836, 0.015057152137160301, -0.021668054163455963, 0.008186964318156242, 0.001616485184058547, -0.006773065775632858, -0.007508112583309412, 0.0023011229932308197, -0.025133179500699043, 0.024239297956228256, -0.02250528335571289, -0.022835392504930496, -0.012621888890862465, 0.017313657328486443, 0.037485525012016296, -0.0294965710490942, 0.006621310021728277, 0.0091245723888278, 0.04711255058646202, 0.02189815044403076, 0.021730005741119385, 0.017605867236852646, 0.011773554608225822, 0.014428438618779182, 0.000049067079089581966, 0.006930556148290634, 0.04498903453350067, -0.01072072982788086, 0.0032622222788631916, -0.001936966786161065, 0.0074597494676709175, -0.028973951935768127, 0.019919872283935547, 0.009385611861944199, 0.010819689370691776, -0.010931883007287979, 0.017665453255176544, 0.005868835374712944, -0.0022178110666573048, -0.008900652639567852, 0.004972462542355061, 0.02301723323762417, 0.0016077652107924223, -0.002315690740942955, -0.014924758113920689, -0.0014319675974547863, -0.006440150085836649, 0.02879941649734974, 0.005467101000249386, 0.006821861024945974, -0.005780985578894615, 0.03959480673074722, -0.03982088342308998, 0.01368049904704094, -0.0007320725126191974, 0.015360940247774124, 0.013307718560099602, -0.015394807793200016, -0.011085730977356434, 0.04395831376314163, 0.0010891102720052004, -0.010327525436878204, -0.022415123879909515, 0.004342618864029646, 0.004925026558339596, -0.0061583989299833775, 0.008441651239991188, -0.03184467926621437, -0.010078946128487587, -0.004388904199004173, -0.00344158336520195, 0.011546207591891289, -0.005546608939766884, 0.009964464232325554, 0.010340939275920391, 0.01973135396838188, -0.008686840534210205, -0.02490721456706524, -0.012846552766859531, 0.002317793434485793, -0.015968866646289825, 0.0006345110014081001, 0.013770567253232002, 0.005886882543563843, 0.004637888632714748, 0.011469878256320953, -0.021059367805719376, 0.0024146167561411858 ]
[ 0.2579599618911743, 0.04600370302796364, -0.11696754395961761, 0.059767089784145355, 0.036237798631191254, 0.26674261689186096, -0.014479203149676323, -0.06750818341970444, -0.45633190870285034, -0.3974975645542145, -0.13942177593708038, 0.5256587862968445, -0.6665984988212585, -0.5275200605392456, -0.3201439380645752, 0.07440860569477081, 1.0031815767288208, 0.24450774490833282, -0.40241777896881104, -0.7109168171882629, 0.10707180202007294, 0.04589279368519783, 0.569043755531311, -0.06861603260040283, 0.4126930832862854, -0.49453404545783997, 0.598475992679596, 0.3258107900619507, 0.5061723589897156, -0.02817026898264885, -0.349587619304657, 0.8320980072021484, 0.04218890145421028, 0.13933829963207245, 0.0968455821275711, 0.1624404788017273, -0.2784636318683624, -0.4290059804916382, -0.03731785714626312, -0.14504435658454895, 0.19803471863269806, 0.10713594406843185, -0.5053523778915405, 0.3550914525985718, -0.3016881048679352, -0.017452772706747055, -1.3753448724746704, 0.6194442510604858, 0.08094695955514908, 0.3874289393424988, -0.7630168199539185, 0.1131642609834671, 0.3916688561439514, 0.11256948113441467, -0.014769111759960651, 0.21575886011123657, -0.5660802721977234, 0.19696882367134094, 0.32190555334091187, -0.332785427570343, -0.05608575791120529, -0.04820362851023674, -0.5711861848831177, -0.061184030026197433, -0.1508922278881073, 0.36577728390693665, 0.3309066891670227, -0.694342851638794, -0.10210081934928894, 0.24139288067817688, -0.07801302522420883, -0.5421506762504578, -0.3721673786640167, 0.17013297975063324, -0.6783159375190735, 0.24713414907455444, 0.08081639558076859, -0.19348014891147614, 0.36953189969062805, -0.15035291016101837, 0.03543030470609665, 0.20706821978092194, 0.6339982748031616, 0.17628654837608337, 0.2771243751049042, 0.3552221655845642, -0.6880360841751099, 0.165388286113739, -0.5489473342895508, -0.05693725124001503, -0.7025697827339172, -0.3759033977985382, 0.019795812666416168, 0.8842072486877441, 0.2509707510471344, 0.4041006565093994, 0.4264381527900696, -0.4320072531700134, 0.054050933569669724, -0.03713243827223778, -0.12074242532253265, 0.26570379734039307, 0.3627733588218689, -0.22693777084350586, -0.18764452636241913, -0.8862617611885071, -0.2797403633594513, -0.682703971862793, -0.6223525404930115, 0.3081650733947754, -0.9602036476135254, -0.230501189827919, 0.3321620225906372, -0.1445288360118866, 0.036520108580589294, -0.13949358463287354, 0.2960238754749298, 0.07419683039188385, -0.37404128909111023, 0.08621734380722046, 0.06360679864883423, 1.3698768615722656, 0.11287768185138702, 0.21669574081897736, -0.3005256950855255, -0.01648237742483616, 0.31159716844558716, -0.12851335108280182, -0.2589665949344635, -0.03788599744439125, -0.0824083760380745, 0.7985972762107849, -0.1745878905057907, -0.0628698468208313, 0.18978244066238403, 0.057529181241989136, 0.4405202567577362, 0.12930792570114136, 0.13262277841567993, 0.6955459713935852, -0.21035198867321014, -0.6504318118095398, -0.0956411063671112, -0.15828758478164673, 0.5317732691764832, -0.6428470015525818, -0.08391682803630829, -0.11614859849214554, -0.19030041992664337, -0.04447409138083458, -0.5824546217918396, -0.04606742784380913, -0.6269074082374573, -0.4075009524822235, -0.0022336828988045454, 0.657041072845459, -0.10115256160497665, 0.034797538071870804, 0.07383135706186295, -0.04755621775984764, 0.01525832712650299, -0.639195442199707, -0.21535661816596985, -0.3663851022720337, -0.0719505101442337, -0.11187334358692169, 0.5841540098190308, 0.47733595967292786, -0.23451295495033264, -0.08653873205184937, -0.11493965983390808, -0.35535627603530884, 0.3054785132408142, -0.22014780342578888, -0.42973095178604126, 0.039806023240089417, 0.3739992082118988, 0.2826777696609497, 0.10566896945238113, 0.23159492015838623, -0.7676625847816467, 0.027346787974238396, -0.10932513326406479, -0.7725722193717957, 0.5152607560157776, -0.04725269600749016, 0.3189713954925537, -0.23762960731983185, 0.052731677889823914, -0.14025287330150604, 0.6248716711997986, -0.3132598102092743, 0.654120683670044, -0.45230230689048767, 1.2613738775253296, -0.4490150809288025, -0.2222500443458557, 0.09538295120000839, 0.38737618923187256, 0.11985494941473007, -0.015924405306577682, -0.2416406124830246, 0.40234845876693726, -0.3766525983810425, -0.33625873923301697, -0.1362428516149521, -0.07274163514375687, -0.4170498549938202, 0.059857334941625595, 0.16302765905857086, 0.5309860706329346, -0.0033697583712637424, 0.050915539264678955, 0.02021900750696659, 0.7145609259605408, -0.35650962591171265, -0.11473660916090012, 0.2744916081428528, -0.78663170337677, -0.17739902436733246, 0.14688563346862793, -0.102598175406456, 0.2357974499464035, 0.45811083912849426, 0.1904861181974411, 0.8328679800033569, 0.6809962391853333, 0.2769539952278137, 0.813875138759613, -0.5540022253990173, 0.1827959269285202, -0.28401535749435425, 0.0633123517036438, -0.150886669754982, -0.2622676491737366, -0.008604750037193298, 0.24776716530323029, -0.386201947927475, 0.08049096912145615, -0.37210461497306824, -0.2931482791900635, 0.5751580595970154, -0.8186097145080566, 0.19709669053554535, -0.07570245116949081, -0.7489780783653259, -0.03179926052689552, 0.30136340856552124, -0.937654435634613, -0.24771131575107574, -0.3086802661418915, -0.010442720726132393, 0.3095717430114746, -0.6559508442878723, 0.10158160328865051, -0.7808156609535217, 0.22926557064056396, -0.16927118599414825, -0.018637262284755707, -0.3072862923145294, 0.0891401544213295, 0.09462087601423264, 0.10300621390342712, 0.01480348501354456, -0.7118977904319763, -0.722816526889801, -0.6396216750144958, -0.10400857031345367, 0.6804560422897339, 0.4395802617073059, 0.6923080086708069, -0.12378714978694916, -0.014369755983352661, -0.095980204641819, 0.3145081400871277, -0.6950162649154663, -0.08738444000482559, 0.21994785964488983, 0.007784388959407806, -0.31977784633636475, -0.13364087045192719, 0.7262334227561951, 0.6271295547485352, 0.22139683365821838, -0.5906327366828918, 0.09651283919811249, -0.19159962236881256, -0.5336872339248657, 0.008961424231529236, -0.3418758809566498, -0.02510685846209526, 0.10946737229824066, -0.03216920793056488, -0.38189828395843506, -0.1519494652748108, 1.0907304286956787, -0.08851052075624466, 0.5497931241989136, 0.20480623841285706, 0.03530769795179367, -0.2571753263473511, 0.2427678108215332, -0.10187848657369614, 0.11284814774990082, -0.22166945040225983, 0.278462678194046, -0.5965806245803833, 0.5064199566841125, -5.859923362731934, -0.014297973364591599, -0.11131440848112106, -0.2974523603916168, -0.09792501479387283, 0.10805842280387878, 0.5846943855285645, 0.0936853215098381, 0.32875412702560425, 0.26451003551483154, -0.42816558480262756, 0.18513846397399902, -0.37199681997299194, 0.5505772233009338, -0.03633511811494827, -0.4773712158203125, -0.4245660603046417, -0.4220883250236511, 0.4919985830783844, -0.11243381351232529, 0.3166515529155731, -0.3946278691291809, 0.22281594574451447, 0.4343563914299011, -0.20305971801280975, 0.0648498684167862, -0.7548359036445618, -0.32814687490463257, 0.3665810823440552, -0.485435426235199, -0.5350441932678223, -0.3246772587299347, -0.3750683069229126, -0.043269477784633636, 0.9388243556022644, 0.6181914806365967, 0.0473097488284111, 0.23609726130962372, 0.2715688943862915, -0.3813091814517975, 0.534757137298584, 0.4668983221054077, -0.034597884863615036, 0.0298383217304945, 0.22249028086662292, 0.15538854897022247, -0.4234214723110199, 0.36514008045196533, -0.34262120723724365, 0.5240972638130188, -0.2115999311208725, 0.14096447825431824, 0.15206021070480347, 0.049703117460012436, 0.531802773475647, -0.007221080828458071, 0.5365699529647827, -0.1632978767156601, 0.33131882548332214, -0.20171502232551575, -0.40161633491516113, -0.5559159517288208, -0.22004981338977814, -0.8009397983551025, -0.15431910753250122, 0.6013535261154175, -0.8124849796295166, -0.2806159555912018, 0.7375367879867554, 0.06770865619182587, -0.3257752060890198, 0.10489871352910995, -0.32230710983276367, -0.7540042996406555, 0.5724642872810364, -0.21015095710754395, 0.12635551393032074, 0.26481860876083374, 0.36978766322135925, 0.05831491947174072, -0.25868600606918335, -0.08413214981555939, 0.13686710596084595, -0.21215949952602386, -0.16751167178153992, -0.672917902469635, -0.5749607682228088, -0.21042445302009583, -0.2462347149848938, 0.2966229319572449, 0.8543207049369812, -0.24785731732845306, 0.14133960008621216, 1.033661961555481, 0.2842158377170563, -0.0987873375415802, 0.28737130761146545, 0.1760059893131256, 0.39200806617736816, -0.14795364439487457, 0.6607409715652466, 0.30496397614479065, -0.5439993143081665, -0.3845401704311371, -0.21780264377593994, 0.3716456890106201, -1.0006874799728394, 0.10238137096166611, 0.447578102350235, -0.3059770464897156, -0.218783438205719, -0.08984793722629547, -0.11837559938430786, -0.14926746487617493, 0.5200930237770081, -0.16300974786281586, -0.0518820695579052, 0.11174611002206802, 0.8444515466690063, -0.48321259021759033, -0.13727791607379913, 0.07596476376056671, -0.5090115070343018, 0.4379240572452545, 0.3151494264602661, -0.0022548020351678133, 0.1395573914051056, 0.4319262206554413, -0.6249505877494812, -0.15026701986789703, 0.3926136791706085, 0.14363612234592438, -0.11524026840925217, 0.5011569261550903, 0.28179824352264404, -0.7019351720809937, -0.4245845377445221, 0.16180121898651123, 0.3426758646965027, -0.30830737948417664, 0.35805845260620117, -0.15429526567459106, 0.3137113153934479, -0.30303171277046204, 0.02202802710235119, -0.25593331456184387, 0.1398630142211914, -0.028358513489365578, -0.4636494219303131, 0.019646460190415382, 0.4845457971096039, -0.3361406624317169, -0.1923707127571106, 0.019730783998966217, 0.09237593412399292, -0.29374152421951294, -0.04518886283040047, -0.12685000896453857, 0.13810034096240997, -0.30922701954841614, 0.3433980643749237, 0.2043251097202301, -0.5999529361724854, 0.10418739914894104, -0.3928062617778778, 0.054307740181684494, -0.24028228223323822, -0.3657486140727997, 0.15454398095607758, 0.13423098623752594, -0.26692020893096924, -0.2792825996875763, -0.2233683168888092, -0.26013848185539246, 0.36159372329711914, -0.5745452642440796, 0.2484198659658432, 0.42634302377700806, -0.11607279628515244, 0.10751991719007492, 0.44458961486816406, -0.4915807843208313, -0.12825851142406464, 0.15494927763938904, 0.606450617313385, -0.3078517019748688, 0.47976282238960266, -0.1629515439271927, -0.19310897588729858, -0.42619627714157104, 0.5019439458847046, 0.5784252882003784, 0.14278675615787506, -0.2998775243759155, 0.2531452775001526, 0.2594524621963501, -0.10851948708295822, 0.20445901155471802, -0.046301767230033875, -0.7401986718177795, 0.22384832799434662, 0.07070200890302658, -0.5530260801315308, 0.24933463335037231, 0.737052321434021, 0.10579513758420944, 0.05551706627011299, 0.4526551365852356, 0.07635222375392914, -0.061761364340782166, -0.17887459695339203, -0.13131269812583923, -0.08219780027866364, -0.028109755367040634, -0.2919812798500061, 0.05284152552485466, 0.6355289220809937, -0.39481112360954285, -0.7941346168518066, 0.6266722083091736, -0.11641018837690353, -0.29043474793434143, -0.08830010890960693, -0.26371756196022034, -0.19925780594348907, -0.2768966257572174, 0.4552080035209656, -0.18883121013641357, 0.24792751669883728, 0.13369324803352356, -0.4397032558917999, -0.006637429818511009, -0.3720398247241974, 0.04540523514151573, -0.22736570239067078, -0.618101179599762, -0.23406025767326355, 0.33921587467193604, -0.2032698690891266, 0.10198801755905151, 0.6422898769378662, 0.88631671667099, -0.3370402455329895, 0.3324257433414459, -0.4430758059024811, 0.6765232682228088, 0.04112808033823967, -0.38102078437805176, -0.5852202773094177, -0.1522541046142578, 0.7323225140571594, -0.2733176052570343, 0.3326273560523987, 0.5303571224212646, 0.7003418207168579, -0.01266323309391737, -0.3500400483608246, -0.2648482024669647, 0.042222414165735245, 0.3364209830760956, 0.0006168984109535813, -0.47284263372421265, -0.5023201107978821, -0.26436471939086914, 0.28689634799957275, 0.04892895743250847, -0.2987196445465088, -0.47167345881462097, 0.7792358994483948, 0.021242232993245125, 0.38175156712532043, -0.26288995146751404, 0.4160010516643524, 0.3258228003978729, -0.006147691048681736, 0.03597460687160492, -0.15796102583408356, 0.49876922369003296, 0.32239848375320435, -0.04711137339472771, 0.2625822126865387, 0.09848172217607498, 0.45617279410362244, -0.582830011844635, 0.5725015997886658, -0.7835990786552429, 0.1802528351545334, -0.6736799478530884, 0.5461574196815491, -0.3509237468242645, -0.39958393573760986, -0.19800657033920288, -0.2784428298473358, -0.37265199422836304, 0.20068487524986267, 0.11462094634771347, 0.6539623141288757, 0.4303075075149536, 0.05078306421637535, 0.1986231505870819, -0.5365399122238159, 0.6361570954322815, 0.6528864502906799, -0.39940908551216125, 0.18054480850696564, 0.32438164949417114, 0.05053907632827759, -0.2957012355327606, -0.9942018389701843, -0.10160724818706512, -0.2305823117494583, -0.05324813351035118, 0.04546920210123062, 0.6561834812164307, -0.5090668201446533, 0.09239646047353745, 0.297025203704834, -0.19383791089057922, 0.4762313663959503, 0.5118143558502197, 0.3298567235469818, 0.3552134335041046, 0.030732300132513046, -0.32191598415374756, -0.15868139266967773, -0.002665264066308737, 0.4566505551338196, 0.30082833766937256, 0.4179675877094269, 0.3617717921733856, 0.7470001578330994, 0.5241366624832153, 0.04571595415472984, 0.6023999452590942, 0.3945496678352356, 0.012398095801472664, 0.30693215131759644, -0.3269388675689697, -0.441629022359848, 0.5102110505104065, 0.7009210586547852, 0.4293435513973236, -0.5388564467430115, -0.14613009989261627, 0.0201950054615736, 0.15519793331623077, 0.5080556273460388, 0.325002521276474, -0.3881303668022156, 0.3396637737751007, 0.5574296116828918, -0.21702884137630463, 0.14679543673992157, 0.6315228343009949, -0.4582929015159607, -0.17541299760341644, 0.7634785771369934, -0.13933083415031433, -0.1575159877538681, 0.10518091917037964, -0.26087459921836853, 0.41717424988746643, 0.2599502503871918, 0.25793397426605225, 0.44232046604156494, 0.12447170913219452, 0.13560543954372406, 0.0681467205286026, 0.3349733352661133, -0.2402261346578598, -0.3747014105319977, 0.3879319727420807, -0.2600140869617462, -0.22074373066425323, -0.1286119520664215, -0.7035965323448181, 0.25372961163520813, -0.4971845746040344, 0.0293185543268919, 0.15029187500476837, -0.12114635854959488, 0.07760748267173767, -0.038291122764348984, -0.8797439336776733, -0.1539895087480545, 0.05885932967066765, -0.29690489172935486, 0.10131128132343292, -0.042720817029476166, -0.051355645060539246, 0.042255111038684845, -0.6610729694366455, 0.3375035524368286, -0.1640319973230362, 0.4509691298007965, -0.10728622227907181, -0.2600066065788269, 0.39773935079574585, 0.37162479758262634, 0.011458798311650753, 0.5979675650596619, 0.7649803161621094, -0.4046165943145752, 0.21611227095127106, -0.4303372800350189, 0.171477273106575, -0.552646279335022, -0.6914839148521423, -0.21151210367679596, -0.19475434720516205, 0.996219277381897, 0.06011026352643967, -0.14446280896663666, -0.0857616737484932, 0.47670358419418335, 0.5530107021331787, 0.45499348640441895, -0.5211970806121826, -0.144267275929451, -0.17388299107551575, -0.12835325300693512, -0.3647655248641968, 0.625203549861908, 0.21742253005504608, -0.19527223706245422, -0.31511029601097107, 0.7225796580314636, -0.14223630726337433, -0.4710664451122284, 0.1665278524160385, -0.2234809249639511, 0.04962246119976044, -0.7634972929954529, -0.18384574353694916, -0.37435382604599, -0.5681871175765991, -0.16609351336956024, 0.05654250085353851, 0.06792115420103073, -0.3518582880496979, 0.12606918811798096, 0.01556581910699606, 0.009456236846745014, 0.2627553641796112, -0.3114718496799469, -0.25808706879615784, 0.044790126383304596, -0.6958028078079224, -0.6421153545379639, 0.08871632069349289, 0.11545620113611221, -0.3992459774017334, -0.22041551768779755, -0.019890056923031807, -0.004780355375260115, 0.04525153711438179, 0.29964321851730347, -0.3119901716709137, -0.1180557832121849, 0.15985862910747528 ]
BACKGROUND Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. Accumulating evidence suggests that the epigenome serves as the interface between the genome and the environment and that hypermethylation of stem cell polycomb group target genes is an epigenetic hallmark of cancer. The objective of this study was to determine the functional role of epigenetic factors in endometrial cancer development. METHODS AND FINDINGS Epigenome-wide methylation analysis of >27,000 CpG sites in endometrial cancer tissue samples (n = 64) and control samples (n = 23) revealed that HAND2 (a gene encoding a transcription factor expressed in the endometrial stroma) is one of the most commonly hypermethylated and silenced genes in endometrial cancer. A novel integrative epigenome-transcriptome-interactome analysis further revealed that HAND2 is the hub of the most highly ranked differential methylation hotspot in endometrial cancer. These findings were validated using candidate gene methylation analysis in multiple clinical sample sets of tissue samples from a total of 272 additional women. Increased HAND2 methylation was a feature of premalignant endometrial lesions and was seen to parallel a decrease in RNA and protein levels. Furthermore, women with high endometrial HAND2 methylation in their premalignant lesions were less likely to respond to progesterone treatment. HAND2 methylation analysis of endometrial secretions collected using high vaginal swabs taken from women with postmenopausal bleeding specifically identified those patients with early stage endometrial cancer with both high sensitivity and high specificity (receiver operating characteristics area under the curve = 0.91 for stage 1A and 0.97 for higher than stage 1A). Finally, mice harbouring a Hand2 knock-out specifically in their endometrium were shown to develop precancerous endometrial lesions with increasing age, and these lesions also demonstrated a lack of PTEN expression. CONCLUSIONS HAND2 methylation is a common and crucial molecular alteration in endometrial cancer that could potentially be employed as a biomarker for early detection of endometrial cancer and as a predictor of treatment response. The true clinical utility of HAND2 DNA methylation, however, requires further validation in prospective studies. Please see later in the article for the Editors' Summary.
[ -0.0026609920896589756, 0.007935384288430214, -0.012438260018825531, 0.022692957893013954, 0.020471110939979553, 0.017586298286914825, 0.01240028440952301, 0.015343653038144112, -0.012956017628312111, -0.04072421416640282, 0.004425679333508015, 0.010693846270442009, -0.00915564876049757, 0.018386878073215485, 0.013356098905205727, 0.02728155069053173, -0.029125582426786423, -0.017908085137605667, 0.01136043667793274, -0.0019604540430009365, 0.00611709151417017, -0.010021496564149857, 0.010522431693971157, 0.020562101155519485, -0.004462163429707289, 0.024531032890081406, 0.018704960122704506, -0.006086558103561401, 0.00024519278667867184, -0.00607187207788229, -0.0008819550275802612, -0.008311005309224129, 0.03304804116487503, 0.012883409857749939, -0.00039589707739651203, 0.005037648603320122, -0.003140316577628255, 0.02490984834730625, 0.025615569204092026, -0.004896652884781361, 0.011648820713162422, -0.013021029531955719, 0.0045413910411298275, -0.006805421784520149, -0.0077116284519433975, 0.032979920506477356, 0.0013848860980942845, 0.01719205640256405, 0.0007909354753792286, 0.008302360773086548, -0.009567191824316978, 0.0005103554576635361, -0.011341048404574394, -0.014262487180531025, -0.006432706955820322, -0.0019671828486025333, 0.019517913460731506, -0.0050826529040932655, -0.005065386649221182, 0.014863640069961548, 0.044575877487659454, -0.02367061749100685, 0.023492272943258286, -0.020143309608101845, -0.03415022790431976, -0.06696641445159912, 0.025914747267961502, -0.004969144240021706, -0.0011348733678460121, -0.008741496130824089, 0.004615369252860546, 0.007538866251707077, 0.03185582906007767, -0.024488376453518867, 0.003843118902295828, -0.007090415805578232, -0.00484749861061573, 0.012818665243685246, 0.037138067185878754, 0.020726704970002174, -0.007039469666779041, 0.0051325345411896706, -0.005436594132333994, 0.02929650992155075, -0.013972815126180649, 0.00437585124745965, -0.014955472201108932, -0.004179995507001877, -0.0012803152203559875, 0.010745968669652939, -0.007284541614353657, -0.03298009932041168, -0.01709900237619877, -0.0013763555325567722, -0.061704523861408234, 0.011329824104905128, 0.008759990334510803, -0.01713990606367588, 0.007713182829320431, 0.0007251640781760216, -0.01906522363424301, 0.00288728391751647, 0.014719820581376553, 0.021039696410298347, -0.01540880836546421, 0.012887036427855492, -0.009440352208912373, 0.009271715767681599, 0.019330700859427452, 0.014945507980883121, -0.01355375349521637, -0.00469918642193079, 0.005000364035367966, 0.01723206229507923, 0.017939992249011993, -0.024647481739521027, -0.03366394340991974, 0.016108296811580658, 0.01287556067109108, 0.034458741545677185, 0.002342330291867256, 0.020277079194784164, -0.002280866028741002, 0.017542175948619843, -0.0018240247154608369, -0.031155608594417572, -0.039395302534103394, 0.0032460209913551807, 0.006562121212482452, -0.0023915981873869896, -0.007399163208901882, -0.003579388838261366, 0.016996845602989197, -0.01045332569628954, 0.0030510169453918934, 0.004841200076043606, -0.021611221134662628, -0.013042422942817211, -0.009843522682785988, -0.001484208507463336, 0.028394881635904312, 0.008732502348721027, 0.004902814980596304, 0.008072180673480034, 0.01175103522837162, 0.0017072324408218265, -0.008147940039634705, -0.01511109247803688, -0.020045816898345947, -0.011405374854803085, 0.0039940765127539635, -0.012619154527783394, -0.020402511581778526, -0.015616079792380333, 0.020802583545446396, -0.008690574206411839, -0.013979031704366207, 0.014372991397976875, 0.008887125179171562, -0.009003063663840294, -0.010083204135298729, -0.0215501319617033, -0.010933918878436089, 0.009974044747650623, -0.004838045220822096, -0.025909796357154846, -0.03850236535072327, 0.003327458631247282, 0.009024633094668388, 0.005070294253528118, -0.016901414841413498, -0.0013250312767922878, 0.00579513655975461, 0.012089462019503117, -0.026685332879424095, -0.006776744034141302, -0.00843281950801611, 0.0070730941370129585, -0.01611577719449997, 0.0666121244430542, -0.0186617374420166, 0.0004607922164723277, -0.007574046030640602, -0.004949101246893406, -0.015487929806113243, 0.0028247612062841654, 0.031079553067684174, -0.006082931533455849, -0.003566117724403739, 0.004453717730939388, 0.013079973869025707, 0.0271668191999197, -0.0022572847083210945, 0.024603957310318947, -0.023509539663791656, 0.003407388459891081, 0.012871844694018364, 0.002434179186820984, -0.01864638365805149, -0.031110601499676704, 0.007545770145952702, -0.017597582191228867, 0.014755412936210632, 0.019266614690423012, 0.01291270088404417, 0.024707406759262085, 0.0068723829463124275, -0.02240687794983387, -0.0050160447135567665, -0.00895349495112896, 0.030377035960555077, -0.028169147670269012, -0.009306931868195534, -0.0030198809690773487, 0.006003114394843578, 0.016124244779348373, -0.016295908018946648, 0.0047272443771362305, -0.0202937088906765, -0.014135794714093208, 0.002888764487579465, 0.01890413835644722, -0.0013158582150936127, -0.0006063827313482761, 0.03062637522816658, -0.0029990922193974257, 0.004994311835616827, 0.008327914401888847, -0.019747911021113396, 0.006786637008190155, -0.014580144546926022, -0.024346552789211273, -0.013126568868756294, 0.014407011680305004, 0.00908871553838253, 0.0057914722710847855, 0.011625003069639206, 0.0014166808687150478, 0.006133038550615311, -0.009791633114218712, 0.0015822825953364372, -0.020669657737016678, 0.03394588828086853, -0.012947414070367813, -0.012451507151126862, 0.0111592598259449, 0.02211631089448929, 0.021336998790502548, 0.009613621979951859, -0.023495353758335114, 0.006664923392236233, -0.01445017009973526, -0.007354355417191982, -0.03294849395751953, 0.043515894562006, 0.00012835673987865448, -0.0348762683570385, -0.003368227044120431, 0.025088081136345863, -0.009276268072426319, -0.004863560199737549, 0.00991186872124672, 0.018296683207154274, -0.028770241886377335, -0.013032380491495132, -0.042361099272966385, 0.021396659314632416, 0.006975453346967697, 0.03855722025036812, -0.016713082790374756, 0.006529496517032385, -0.0009851291542872787, -0.00011413800530135632, -0.08156134188175201, -0.010381261818110943, 0.002501403447240591, -0.018702220171689987, 0.011314266361296177, -0.005527786444872618, 0.015275480225682259, 0.0055357301607728004, 0.011084766127169132, -0.029325833544135094, 0.024162575602531433, 0.00807955302298069, -0.0064727808348834515, -0.018615081906318665, -0.0132783567532897, 0.0009937635622918606, 0.009736057370901108, -0.01121272798627615, -0.004269874654710293, -0.045954518020153046, 0.022908637300133705, 0.026014994829893112, -0.009962593205273151, 0.01993367448449135, 0.01121174730360508, 0.03783146291971207, 0.009899185039103031, -0.009701844304800034, -0.011008379980921745, 0.009695105254650116, -0.011544745415449142, -0.0249444879591465, 0.009628260508179665, -0.021347643807530403, 0.01266840472817421, 0.00969492644071579, -0.002668999368324876, -0.012566355988383293, -0.013078988529741764, 0.04782263562083244, -0.0072883907705545425, 0.01724417135119438, 0.01698339357972145, -0.0009734595660120249, 0.015774616971611977, 0.014249976724386215, -0.01025612186640501, 0.0022458406165242195, 0.01187396701425314, 0.01032477617263794, -0.022085336968302727, 0.009830452501773834, 0.024070873856544495, 0.011723627336323261, -0.017134685069322586, -0.018044257536530495, -0.04413102567195892, -0.024478325620293617, -0.012356137856841087, -0.016993077471852303, 0.018795829266309738, -0.006867038551717997, 0.012034064158797264, 0.019152216613292694, -0.006783897057175636, 0.005585771985352039, 0.015127130784094334, 0.014373527839779854, -0.006004648748785257, 0.005048893392086029, 0.011269520968198776, -0.019077956676483154, -0.003439669730141759, -0.0056260209530591965, -0.007541452534496784, -0.0042580533772706985, -0.01608680933713913, -0.0039909109473228455, -0.01498015969991684, -0.010405153036117554, -0.03921830281615257, -0.0075475615449249744, -0.029547957703471184, -0.010732663795351982, -0.014731083065271378, -0.008385749533772469, 0.0043655321933329105, 0.037478916347026825, 0.01209738478064537, -0.016053665429353714, -0.020843710750341415, 0.014349342323839664, -0.008649254217743874, 0.008973708376288414, 0.0000971788540482521, 0.003760612104088068, 0.0024261714424937963, 0.004498828202486038, 0.03466734290122986, 0.010009350255131721, -0.02407696284353733, 0.008028891868889332, 0.03016907349228859, -0.011735724285244942, -0.011404560878872871, 0.01620335504412651, 0.01554590743035078, -0.014789718203246593, 0.0008733428549021482, 0.0004733012174256146, -0.014306159690022469, -0.011646220460534096, -0.0037856167182326317, 0.03339940309524536, 0.012677714228630066, 0.006437305826693773, 0.0017457744106650352, -0.01015447173267603, 0.07203863561153412, -0.007767073810100555, 0.013918891549110413, -0.019226375967264175, -0.009071127511560917, -0.03180701658129692, -0.007999110035598278, 0.0015573520213365555, -0.01596873253583908, 0.011946393176913261, 0.012796705588698387, -0.021860016509890556, 0.020907025784254074, -0.018469959497451782, -0.02337624877691269, -0.006397981196641922, -0.008311417885124683, -0.01162412203848362, -0.0012382017448544502, -0.022448504343628883, -0.002306794747710228, -0.02652822993695736, -0.022956248372793198, 0.008505907841026783, -0.002424576785415411, -0.04768037050962448, -0.0016691398341208696, -0.011041071265935898, -0.030952060595154762, 0.0041853636503219604, 0.015309964306652546, -0.010999917984008789, -0.006407008972018957, -0.0078113265335559845, 0.047210026532411575, 0.023837264627218246, 0.02639561891555786, 0.007386470679193735, -0.004257246386259794, -0.0018829690525308251, 0.0014926481526345015, -0.014813858084380627, 0.008037564344704151, 0.013718631118535995, -0.01571503095328808, -0.0016328281490132213, 0.035024676471948624, -0.006159985437989235, 0.0052572679705917835, 0.02304847724735737, -0.0086117684841156, -0.004370526876300573, 0.015403258614242077, 0.00903651025146246, 0.0004935783799737692, -0.005341758020222187, 0.010544892400503159, -0.00031249801395460963, 0.014294888824224472, 0.0004806856159120798, -0.029366523027420044, -0.029239719733595848, 0.02098238281905651, 0.007143592461943626, 0.0008273627609014511, -0.01903168112039566, -0.02657425031065941, -0.004006312228739262, -0.003479564096778631, -0.023748332634568214, 0.0278034508228302, -0.004158344119787216, -0.026485545560717583, -0.03187454491853714, -0.02368604950606823, 0.01320086233317852, 0.015130527317523956, -0.016367217525839806, -0.00024011032655835152, 0.00328737567178905, -0.010686613619327545, 0.005565499421209097, 0.016062885522842407, 0.04142247512936592, 0.04613019526004791, 0.016577191650867462, -0.02312191016972065, -0.0744570940732956, -0.010698310099542141, 0.005237165372818708, -0.00768101355060935, 0.018245715647935867, 0.014271617867052555, -0.012752214446663857, 0.018820885568857193, 0.011508053168654442, -0.0011621571611613035, 0.017793066799640656, 0.004983872175216675, 0.005011857021600008, -0.005343182012438774, 0.01371169462800026, 0.02212054654955864, 0.002205760683864355, -0.01634530909359455, 0.00015606079250574112, 0.014573859050869942, 0.029545648023486137, 0.017069518566131592, -0.009921817108988762, -0.010082125663757324, -0.016564369201660156, -0.08093332499265671, 0.0005774358287453651, -0.0220505241304636, 0.002368385437875986, -0.0068335821852087975, -0.0051482259295880795, 0.010509568266570568, -0.010660853236913681, -0.01431222166866064, -0.019259903579950333, -0.001005243742838502, -0.006467628292739391, -0.0033875517547130585, 0.00042514619417488575, -0.00030987896025180817, -0.006612803321331739, 0.020725911483168602, -0.0061942157335579395, -0.020409245043992996, 0.019191641360521317, -0.000912756659090519, 0.0022696699015796185, -0.006957293953746557, -0.00787186436355114, -0.010911397635936737, -0.000688113272190094, -0.016492553055286407, 0.017138369381427765, 0.009032784029841423, 0.0026230793446302414, -0.017433002591133118, -0.012794947251677513, -0.01237520296126604, -0.0238858200609684, -0.007883762940764427, -0.02078583836555481, -0.019301140680909157, -0.011773429811000824, -0.0032056234776973724, 0.008939970284700394, -0.010171787813305855, 0.01000179536640644, 0.005052582826465368, -0.005224062129855156, 0.005188442766666412, -0.0043706148862838745, 0.009468126110732555, -0.007707339711487293, -0.0019923748914152384, 0.012700687162578106, 0.0006743136909790337, -0.0387263223528862, -0.002773445565253496, -0.0022008277010172606, 0.002904465887695551, 0.032387975603342056, -0.0013643665006384254, -0.0012542051263153553, 0.008020352572202682, 0.0023220409639179707, -0.008539233356714249, 0.0013312030350789428, -0.016345303505659103, 0.07150006294250488, 0.005362262018024921, 0.01033242791891098, -0.019024167209863663, 0.000930324662476778, 0.001838513184338808, -0.001871489454060793, -0.012653646990656853, -0.023713139817118645, -0.005215209908783436, 0.03885064274072647, -0.00985787995159626, 0.005098099820315838, 0.014882787130773067, 0.0002292548306286335, -0.008760192431509495, 0.008151424117386341, -0.0005662799812853336, 0.005925576202571392, 0.0025585335679352283, -0.0005350984283722937, 0.007118150591850281, -0.026792261749505997, -0.008526851423084736, 0.020130235701799393, -0.012393022887408733, -0.026308486238121986, -0.006562937516719103, -0.020525002852082253, 0.03912324458360672, 0.0007795728743076324, -0.0015459381975233555, -0.0069608064368367195, -0.014617042616009712, 0.01603337563574314, 0.029468052089214325, -0.016601387411355972, 0.0006780105759389699, -0.01635730266571045, 0.036113593727350235, -0.01159568503499031, 0.00616949237883091, 0.0001644953154027462, -0.00547228567302227, -0.00196434510871768, 0.01044695544987917, -0.030837269499897957, 0.017645547166466713, -0.013343940488994122, 0.00033378321677446365, 0.04017326980829239, 0.011123049072921276, 0.01151955220848322, 0.005893687717616558, 0.0018667485564947128, 0.022157274186611176, -0.015441589057445526, 0.022476395592093468, -0.010869388468563557, -0.016976408660411835, 0.01637810468673706, -0.026466505602002144, 0.009957957081496716, -0.015945076942443848, 0.0017970583867281675, -0.016238491982221603, 0.027497241273522377, -0.009552346542477608, 0.0066568790934979916, 0.015926174819469452, 0.004776396788656712, -0.005455964244902134, 0.008784168399870396, 0.00031709508039057255, -0.001655789092183113, 0.0007990896701812744, 0.026515349745750427, 0.0067970724776387215, 0.00258697965182364, 0.011929739266633987, -0.0143964234739542, 0.02921348065137863, 0.012483826838433743, -0.008094331249594688, -0.026716560125350952, 0.0311743151396513, 0.015062098391354084, -0.011262371204793453, -0.0031348320189863443, 0.014988291077315807, 0.02701617404818535, -0.0036189528182148933, 0.0031857320573180914, 0.0036898870021104813, 0.012521296739578247, 0.03485935926437378, 0.02087279222905636, -0.0017193917883560061, 0.01359544787555933, 0.010370185598731041, 0.03191501647233963, 0.004381023813039064, -0.03720822185277939, -0.026096634566783905, -0.027955055236816406, -0.0005372618325054646, 0.014888046309351921, -0.007211168762296438, 0.00841053668409586, 0.0424712710082531, 0.0069672055542469025, -0.016681533306837082, 0.020213019102811813, -0.0030496041290462017, 0.01702185533940792, 0.028007198125123978, -0.005913120694458485, 0.016818925738334656, -0.017123963683843613, -0.015825845301151276, 0.006012703292071819, -0.011760133318603039, 0.0018225088715553284, -0.0041490159928798676, 0.0005739857442677021, -0.0026419723872095346, -0.008977018296718597, 0.020207813009619713, -0.027137618511915207, -0.010594362393021584, 0.013982209376990795, -0.028277061879634857, -0.021795548498630524, 0.040934231132268906, 0.009119520895183086, -0.0097566619515419, -0.0186013150960207, 0.009695859625935555, -0.02173762582242489, 0.028837762773036957, 0.022262338548898697, -0.01878722570836544, -0.005442871246486902, -0.004010974429547787, 0.007860520854592323, -0.004040527157485485, 0.014244774356484413, -0.0030821128748357296, 0.011110331863164902, 0.015011783689260483, 0.012456901371479034, 0.017212390899658203, 0.013713255524635315, -0.004725390579551458, -0.0004693081136792898, 0.02718229405581951, 0.0013321239966899157, -0.0030089658685028553, -0.005473842844367027, -0.022585192695260048, 0.0026816646568477154, -0.006798957008868456, -0.03256109356880188, -0.0012143540661782026, 0.016739878803491592, 0.015638627111911774, -0.03475722670555115, -0.0002519018016755581, -0.007623717188835144, 0.022900892421603203, 0.016921719536185265, 0.015299664810299873, -0.019006770104169846, 0.026708751916885376, -0.050789058208465576, -0.004264577757567167, 0.00950892735272646, 0.004226186778396368, -0.003997385501861572, -0.016110902652144432, 0.004193485714495182, -0.013919785618782043, 0.0037333678919821978, -0.007845987565815449, -0.015887433663010597, 0.0007040956988930702, -0.008583998307585716, -0.017247909680008888, 0.01704038493335247, -0.002851886674761772, -0.005323698744177818, 0.01462691929191351, -0.017529048025608063, -0.0071126301772892475, -0.010909758508205414, -0.02539946138858795, 0.03435460478067398, -0.01849822700023651, 0.015318884514272213, 0.010193144902586937, 0.009166011586785316, -0.01404984574764967 ]
[ 0.5827316641807556, 0.15350405871868134, -0.10634255409240723, 0.054972678422927856, 0.6135595440864563, 0.5728328227996826, 0.08838088810443878, 0.41205543279647827, -0.17169544100761414, -0.5810749530792236, 0.49821943044662476, 0.1861078143119812, -0.11439666897058487, 0.2865901291370392, -0.3527393043041229, 0.6446104645729065, 0.06458994746208191, 0.35979965329170227, -0.03324902802705765, -0.6215800642967224, -0.5129384994506836, -0.5283783078193665, 0.5796922445297241, 0.133412167429924, 0.01889302395284176, -0.22681838274002075, 0.2875418961048126, 0.019313907250761986, 0.2151082307100296, -0.057733528316020966, -0.4109700322151184, 0.7253825068473816, 0.1508529782295227, -0.023330362513661385, -0.05355972424149513, -0.5028942227363586, -0.25035637617111206, -0.000768747297115624, -0.05054974928498268, 0.21965202689170837, -0.1031527891755104, -0.07988163828849792, -0.14117400348186493, 0.6040531992912292, -0.335879385471344, -0.4301229417324066, -1.424837589263916, 0.8777695298194885, -0.15309801697731018, 0.027204371988773346, 0.5931622385978699, 0.17107805609703064, 0.08410132676362991, 0.28506559133529663, 0.23286697268486023, 0.23122863471508026, -0.249760240316391, -0.25775596499443054, 0.14752860367298126, -0.25463980436325073, -0.16780132055282593, 0.00037110981065779924, -0.2400488704442978, -0.25094902515411377, -0.06784997880458832, 0.49759408831596375, 0.37246060371398926, -0.2715485095977783, -0.36613404750823975, -0.20146575570106506, -0.026149161159992218, -0.13092991709709167, -0.053490959107875824, 0.3571399450302124, -0.1354515552520752, 0.32722237706184387, 0.08370794355869293, 0.2089734822511673, 0.43688318133354187, -0.30568215250968933, 0.15629617869853973, -0.17688676714897156, 0.24896231293678284, -0.11044302582740784, 0.7274146676063538, -0.1127939447760582, -0.24053138494491577, 0.6816456913948059, -0.0638028159737587, -0.4314699172973633, 0.00871248822659254, -0.12048286199569702, 0.2920798063278198, 0.8219664096832275, 0.12375250458717346, 0.49175605177879333, -0.02055574767291546, 0.15168367326259613, 0.11789283901453018, 0.2521754205226898, -0.4018549621105194, 0.13584204018115997, 0.14318770170211792, -0.16441328823566437, -0.41721898317337036, -0.16951224207878113, 0.10423550754785538, -0.0012185440864413977, -0.5825002789497375, 0.11675537377595901, -0.8052725195884705, 0.017578857019543648, -0.318654328584671, -0.1273965686559677, -0.04674386605620384, 0.26357945799827576, 0.0843062773346901, -0.7982008457183838, -0.12091465294361115, -0.20793510973453522, -0.4880223870277405, 1.0854946374893188, -0.36783793568611145, 0.32510462403297424, 0.010459857061505318, 0.3699016869068146, 0.45019298791885376, 0.22482068836688995, -0.16314761340618134, 0.3244977295398712, 0.3887689709663391, 0.5517417192459106, -0.5380158424377441, 0.08821690827608109, 0.29165929555892944, -0.10729952901601791, 0.06305460631847382, 0.2920030355453491, 0.9481276869773865, -0.1054295003414154, -0.4889194667339325, -1.05036199092865, -0.036408308893442154, -0.10415361821651459, 0.07460030168294907, -0.6702563762664795, -0.2011009305715561, -0.2367762327194214, -0.050479013472795486, -0.2544328272342682, 0.36126908659935, -0.30466654896736145, -0.7259265780448914, -0.3879038393497467, 0.09644851088523865, 0.17420057952404022, 0.04099300876259804, -0.16595616936683655, -0.1011405810713768, 0.4084993004798889, 0.19367092847824097, 0.32750073075294495, -0.3954804539680481, -0.30345815420150757, 0.737423837184906, 0.04315169155597687, 0.1501757651567459, 0.2228977531194687, -0.11176231503486633, 0.5064952373504639, -0.6416955590248108, -0.09989502280950546, 0.13055819272994995, -0.6481776237487793, 0.1660325676202774, 0.1755734086036682, 0.2714439928531647, -0.11122997850179672, 0.08736947923898697, -0.048366840928792953, -0.5598055720329285, 0.16464121639728546, 0.2661791145801544, -0.6625905632972717, 0.18952107429504395, -0.16549356281757355, 0.3154279887676239, 0.05942559242248535, -0.010504469275474548, -0.3005518317222595, -0.4362848699092865, -0.6992313861846924, 0.9410761594772339, -0.7989283800125122, 1.3982855081558228, -0.49387699365615845, 0.2256477326154709, 1.0897072553634644, 0.27502644062042236, -0.08520570397377014, -0.11326050013303757, 0.018918734043836594, 0.5446186065673828, -0.16043837368488312, -0.9072879552841187, -0.1890856921672821, 0.21008579432964325, -0.4552907347679138, -0.04758105054497719, -0.20146329700946808, 0.5566990971565247, -0.19702698290348053, -0.2795679569244385, -0.10145856440067291, -0.013855335302650928, -0.15083211660385132, -0.13736803829669952, 0.30504605174064636, -0.49481070041656494, -0.25064271688461304, 0.23764672875404358, -0.763240396976471, 0.61551433801651, 0.41351318359375, 0.17243508994579315, 0.9198341369628906, 0.381987065076828, -0.15522006154060364, 0.8222944140434265, -0.3656945824623108, 0.2431037724018097, -0.04518480971455574, 0.11365300416946411, -0.72896409034729, 0.026007506996393204, 0.05083788186311722, -0.22514091432094574, -0.07355605810880661, -0.05667850002646446, 0.3229794502258301, -0.2789503335952759, 0.37408727407455444, -1.2334253787994385, -0.11019638925790787, -0.23786628246307373, -0.5494921207427979, -0.4915469288825989, -0.1620253473520279, -0.8288264870643616, 0.02456885389983654, -0.03154641389846802, 0.19612881541252136, 0.06004059314727783, -0.4778398871421814, -0.31121528148651123, 0.364064484834671, 0.09812142699956894, -0.5117616057395935, 0.04911165311932564, -0.4918658137321472, -0.3036171495914459, 0.3136577010154724, 0.2616536021232605, 0.274736613035202, -0.09992557018995285, -0.3676489591598511, -0.3733527660369873, -0.7040809392929077, 1.1748698949813843, 0.5557674765586853, 0.9720003604888916, 0.1385379135608673, -0.7346029877662659, 0.14445224404335022, -0.06648693978786469, -0.7664018869400024, -0.28184428811073303, 0.7368223071098328, -0.691994309425354, -0.3336135745048523, -0.17391818761825562, 0.49612340331077576, 0.7963822484016418, -0.4695408344268799, -0.23570102453231812, -0.05874166265130043, 0.0366421714425087, 0.021739279851317406, -0.49395570158958435, -0.07311159372329712, -0.3967646658420563, 0.3876149356365204, -0.30958643555641174, -0.13217371702194214, 0.5775814056396484, 0.27351897954940796, 0.01832636445760727, 0.20267990231513977, 0.6011572480201721, -0.1807827651500702, 0.09378724545240402, 0.35808050632476807, 0.11764594167470932, -0.21749375760555267, -0.4509182870388031, 0.29789847135543823, -0.2604086697101593, 0.12848630547523499, -5.857285976409912, 0.2657760977745056, -0.21999846398830414, -0.4181084930896759, -0.19417405128479004, 0.19373352825641632, 1.2575433254241943, 0.060318611562252045, 0.5478624701499939, -0.13559983670711517, 0.2907286584377289, 0.39484596252441406, 0.154754176735878, 0.3353825807571411, -0.10822948068380356, 0.18281352519989014, 0.10549059510231018, -0.1515950709581375, 0.5577368140220642, 0.23545633256435394, 0.41728413105010986, -0.019833505153656006, 0.05043177679181099, 0.3463200330734253, 0.11404368281364441, 0.6334146857261658, -1.0280930995941162, 0.14290091395378113, -0.32279279828071594, -0.4744802713394165, 0.38170087337493896, -0.770872950553894, 0.20838971436023712, -0.42515507340431213, 0.13045500218868256, -0.028961870819330215, 0.07923018932342529, 0.3517167270183563, 0.03680429980158806, -0.06759832054376602, 0.11349537968635559, 0.15130135416984558, -0.31919464468955994, -0.10624781996011734, 0.42515647411346436, 0.4005970358848572, 0.06401024013757706, 0.19734615087509155, -0.1962176412343979, 0.9957271814346313, 0.07986516505479813, -0.15390785038471222, 0.25704169273376465, 0.7154439091682434, 0.38749533891677856, 0.15226198732852936, 0.010662008076906204, -0.03361482918262482, -0.5743942260742188, 0.25293517112731934, 0.03725600242614746, -0.09798980504274368, 0.19766148924827576, -0.7416238188743591, -0.22302675247192383, -0.0291422251611948, -0.8888819217681885, -0.5413277745246887, 0.08715955913066864, -0.06151023507118225, -0.13743700087070465, 0.2244517058134079, -0.001624890835955739, -0.5838953852653503, 0.10434338450431824, -0.33912035822868347, -0.0003806857857853174, 0.2154477834701538, -0.10238482058048248, -0.5318334102630615, -0.1359478384256363, 0.047369569540023804, 0.0732349157333374, -0.04625541344285011, 0.05495275929570198, -0.0535571314394474, -0.4787868559360504, 0.05993807315826416, -0.4363445043563843, 0.28530123829841614, 0.30020827054977417, -0.36933428049087524, -0.10440828651189804, 0.07646281272172928, 0.7057977318763733, 0.5857871174812317, 0.6912120580673218, 0.3614751100540161, 0.4601719379425049, 0.37467148900032043, 0.49365127086639404, -0.34711912274360657, -0.4600927233695984, -0.9316365718841553, -0.3294414281845093, -0.2686963975429535, -0.32793039083480835, 0.10766778886318207, 0.3786480724811554, -0.9778497219085693, 0.3956443965435028, -0.0013822705950587988, -0.3714522123336792, -0.18318644165992737, 0.2539727985858917, -0.46916279196739197, -0.03822913020849228, 0.05406437814235687, 0.7067446708679199, -0.5199394822120667, 0.3516746759414673, 0.13774585723876953, -0.14005592465400696, 0.6521033048629761, 0.3990623354911804, -0.6679274439811707, 0.25772589445114136, 0.760807991027832, -1.065496563911438, 0.13521404564380646, 0.11391694098711014, 0.5944010019302368, -0.421438068151474, -0.29542720317840576, -0.04497409239411354, -0.016569193452596664, -0.4359385371208191, 0.13127340376377106, 0.36206063628196716, 0.18868158757686615, 0.2511184513568878, -0.18514004349708557, -0.029010852798819542, 0.07411637902259827, 0.4939863085746765, -0.01377266924828291, -0.2314426451921463, 0.021171556785702705, 0.19572216272354126, -0.29421842098236084, 0.08707357197999954, 0.12064000219106674, 0.3831152021884918, -0.01613023318350315, -0.1959654837846756, 0.20318585634231567, 0.32635825872421265, -0.058168284595012665, -0.39683663845062256, -0.455689400434494, 0.5322651863098145, -0.06585540622472763, -0.8050822019577026, -0.06695407629013062, -0.1867210865020752, -0.5643640756607056, -0.2177446037530899, -0.6177892088890076, -0.07741975039243698, 0.28052806854248047, -0.03834235295653343, -0.18369632959365845, -0.11503944545984268, 0.09227941930294037, 0.1662760078907013, -0.2927200198173523, -0.36793744564056396, 0.17312145233154297, -0.16764605045318604, -0.06277736276388168, 0.06407366693019867, -0.32865363359451294, -0.35957199335098267, 0.4848349690437317, 0.8134303092956543, 0.8086034655570984, -0.008424398489296436, -0.11734864860773087, -0.39941346645355225, -0.20761139690876007, 0.05488813668489456, -0.1776532679796219, 0.3346673250198364, -0.2872037887573242, -0.10390413552522659, 0.10387308895587921, 0.2452624887228012, 0.3753042221069336, 0.039885543286800385, -0.16612736880779266, 0.020448533818125725, 0.46485400199890137, -0.37722495198249817, 0.19922007620334625, 0.5170183777809143, -0.11618468910455704, -0.17193056643009186, -0.3222695291042328, -0.5514796376228333, -0.008835017681121826, -0.2456459403038025, -0.32582345604896545, -0.07796534895896912, 0.4224655032157898, -0.30000489950180054, -0.07475005835294724, 0.0486825592815876, -0.05939355120062828, -0.3647369146347046, 0.5854110717773438, 0.44291725754737854, 0.07793357223272324, -0.140669584274292, 0.04498011991381645, -0.676141083240509, 0.4830276370048523, 0.532943069934845, -0.5838375687599182, 0.009483704343438148, -0.09502661973237991, -0.42548951506614685, -0.3779294490814209, 0.22132746875286102, 0.0008628614014014602, -0.49922260642051697, -0.1550094485282898, -0.008710532449185848, 0.12196025252342224, 0.35649070143699646, 0.748157262802124, 0.3232710063457489, 0.12693120539188385, -0.2973165810108185, -0.5898878574371338, -0.17750120162963867, 0.22408607602119446, 0.4612046182155609, -0.6649224162101746, -0.3887729346752167, 0.14626985788345337, 0.26774004101753235, -0.44111472368240356, 0.05795789882540703, 0.2820460796356201, 0.5833128094673157, 0.3245052695274353, -0.45799311995506287, -0.47040027379989624, -0.14316041767597198, 0.20788758993148804, -0.20295512676239014, -0.8522970080375671, -0.18673725426197052, -0.1355745494365692, 0.5900213718414307, -0.1776132732629776, -0.0462438240647316, -0.2423768937587738, 0.10828088223934174, -0.454708069562912, 0.10552626103162766, -0.23091909289360046, 0.7262108325958252, 0.3743000030517578, -0.1046047955751419, 0.21650336682796478, -0.3450835049152374, 0.13328726589679718, 0.025033093988895416, 0.00970021914690733, -0.43896302580833435, -0.6863622069358826, 0.425295889377594, -0.3951871395111084, 0.13087305426597595, -0.4790918231010437, 0.5794845223426819, -0.17607668042182922, 0.025216488167643547, -0.5839523077011108, -0.3052467703819275, -0.17116808891296387, -0.6883058547973633, -0.25430557131767273, 0.3109230399131775, -0.14365623891353607, 0.29577890038490295, 0.31209391355514526, 0.5748711228370667, -0.2580994963645935, -0.7201127409934998, 0.7156988978385925, 0.24870802462100983, -0.6909427046775818, 0.548731803894043, 0.3011360168457031, 0.18091484904289246, 0.33532434701919556, -0.32393816113471985, 0.266044944524765, 0.1931980401277542, -0.05848390609025955, 0.15494777262210846, 0.3260321319103241, -0.1737142652273178, 0.03922977298498154, -0.3798975348472595, -0.5991525650024414, 0.8956830501556396, 0.15110303461551666, 0.06334303319454193, 0.8874059319496155, 0.7148741483688354, 0.037129130214452744, -0.13256646692752838, 0.6572214365005493, 0.03649064153432846, 0.364600270986557, 0.008486666716635227, 0.23207888007164001, 0.30175474286079407, 0.5392912030220032, -0.05258457362651825, 0.4157847762107849, 0.20852340757846832, 0.21995902061462402, -0.1138315498828888, -0.785031795501709, -0.15188555419445038, 0.17628587782382965, 0.8014948964118958, 0.17066539824008942, -0.057196006178855896, -0.05660831183195114, 0.22907985746860504, 0.488883376121521, -0.2747916877269745, 0.17217722535133362, 0.0425921194255352, 0.10616413503885269, 0.11715446412563324, -0.5990539789199829, -0.5751714706420898, -0.30384254455566406, -0.3880113959312439, 0.18902048468589783, 0.14827604591846466, -0.47010740637779236, -0.7386718988418579, 0.3109811544418335, -0.2549644708633423, 0.19805344939231873, -0.22314603626728058, 0.44963163137435913, -0.32642656564712524, -0.036795321851968765, 0.4811083674430847, 0.4125383496284485, 0.3002391755580902, -0.30846381187438965, 0.24529701471328735, -0.1658298820257187, -0.3334886133670807, 0.18445029854774475, 0.07540397346019745, -0.6040655970573425, 0.11120150238275528, 0.030455155298113823, 0.0077993436716496944, 0.2213934361934662, -0.22826525568962097, -0.02965734526515007, 0.03988881781697273, -0.24336768686771393, 0.06551077216863632, -0.5127686262130737, -0.3347349166870117, 0.17891345918178558, 0.1902722269296646, 0.05315214768052101, 0.17455893754959106, -0.7957432866096497, 0.5614264607429504, 0.3600981831550598, -0.5374007821083069, -0.15993450582027435, 0.018880894407629967, 0.20659613609313965, 0.013222080655395985, 0.26217880845069885, -0.31948134303092957, 0.04398559406399727, -0.1781410425901413, 0.5918905138969421, -0.6632772088050842, 0.4077633321285248, -0.3832162320613861, -0.4966600835323334, -0.7192057967185974, 0.16830593347549438, 0.8137710690498352, 0.4451987147331238, -0.3391098976135254, 0.22891856729984283, -0.020238563418388367, 0.19157357513904572, 0.3689008355140686, 0.025947390124201775, -0.26481378078460693, -0.4424007833003998, -0.051685139536857605, -0.6708050966262817, 0.6524732708930969, -0.42946183681488037, -0.2842309772968292, -0.29204797744750977, 0.3649163544178009, 0.7057122588157654, 0.07373201847076416, 0.4355142116546631, -0.412689208984375, 0.0885796993970871, -0.5134092569351196, 0.6772052049636841, -0.3816341757774353, 0.5151382088661194, 0.16320732235908508, 0.1431041657924652, 0.26885631680488586, -0.1666533648967743, -0.037440840154886246, -0.4245873987674713, 0.46762022376060486, -0.030442850664258003, 0.08710064738988876, 0.5142754912376404, 0.09911072999238968, -0.30750754475593567, -0.8376492261886597, 0.2271452099084854, -0.28596439957618713, -0.6077044010162354, -0.1068384200334549, 0.1690983921289444, -0.24915294349193573, -0.4958260655403137, -0.17925849556922913, -0.3780134618282318, -0.13265058398246765, -0.29258325695991516 ]
This study examined the association between perceived control and several socioeconomic variables and self-rated health in seven post-communist countries (Russia, Estonia, Lithuania, Latvia, Hungary, Poland, Czech Republic). Questionnaire interviews were used to collect data on self-rated health in the last 12 months, education, marital status, perceived control based on nine questions, and material deprivation based on availability of food, clothing and heating. For each population, two ecological measures of material inequalities were available: an inequality score estimated from the survey data as the distance between the 90th and 10th percentiles of material deprivation, and Gini coefficient from published sources. Data on 5330 men and women aged 20-60 were analysed. Prevalence of poor health (worse than average) varied between 8% in Czechs and 19% in Hungarians. The age-sex-adjusted odds ratio for university vs primary education was 0.36 (0.26-0.49); odds ratios per 1 standard deviation increase in perceived control and in material deprivation were 0.58 (95% CI 0.48-0.69) and 1.51 (1.40-1.63), respectively. The odds ratio for an increase in inequality equivalent to the difference between the most and the least unequal populations was 1.49 (0.88-2.52) using the material inequality score and 1.41 (0.91-2.20) using the Gini coefficient. No indication of an effect of either inequality measure was seen after adjustment for individuals' deprivation or perceived control. The results suggest that, as in western populations, education and material deprivation are strongly related to self-rated health. Perceived control appeared statistically to mediate some of the effects of material deprivation. The non-significant effects of both ecological measures of inequality were eliminated by controlling for individuals' characteristics.
[ -0.0018120729364454746, 0.012168306857347488, -0.0019792295061051846, 0.017549358308315277, 0.000005794689059257507, -0.005098092835396528, 0.010936900041997433, -0.02201388031244278, -0.012579770758748055, 0.019304979592561722, -0.014083778485655785, 0.00984562374651432, -0.02268899604678154, 0.016992023214697838, 0.005517228506505489, 0.015578280203044415, -0.0027978275902569294, 0.02071433886885643, 0.008910354226827621, 0.019452810287475586, -0.024282259866595268, -0.002117914380505681, 0.01022392325103283, -0.001165873371064663, -0.039098724722862244, 0.000598325626924634, -0.016634177416563034, -0.01599896512925625, 0.0043717240914702415, -0.02707967348396778, 0.003801685059443116, 0.004247589968144894, 0.005807909183204174, -0.012787919491529465, -0.007692277897149324, -0.005903964396566153, -0.00032132372143678367, 0.008205109275877476, -0.011949140578508377, -0.004259714391082525, 0.002673395909368992, -0.006602676585316658, 0.003927706740796566, -0.025655608624219894, -0.009560803882777691, 0.007581114303320646, -0.012083668261766434, 0.015673557296395302, -0.02816910669207573, 0.010561985895037651, -0.024041514843702316, 0.0023702592588961124, -0.008015467785298824, -0.0122239850461483, -0.006685241125524044, -0.018370412290096283, 0.02006179466843605, 0.03423311933875084, -0.004708186723291874, 0.0007571643218398094, -0.0304495170712471, -0.034840989857912064, -0.0025980868376791477, -0.0028006555512547493, -0.011319303885102272, -0.06678366661071777, -0.02743196114897728, -0.004649274051189423, 0.0033104042522609234, 0.0030356463976204395, -0.0022528208792209625, 0.01417101826518774, 0.015522319823503494, 0.013042110949754715, 0.006702762097120285, -0.0065328506752848625, 0.018233653157949448, -0.0004805978387594223, 0.02576248161494732, -0.029385827481746674, 0.010754709132015705, 0.0028117389883846045, -0.008966372348368168, 0.034527041018009186, 0.0056512197479605675, -0.019170163199305534, 0.002262325491756201, -0.002129483502358198, 0.007211330346763134, 0.004518682137131691, -0.014628412202000618, -0.011229977011680603, -0.010918160900473595, -0.01161724142730236, -0.04060930758714676, -0.024501167237758636, 0.013314822688698769, 0.023962706327438354, -0.00032874615862965584, -0.022762196138501167, -0.002564800437539816, 0.011629924178123474, 0.02250521630048752, -0.016153663396835327, 0.01797959953546524, 0.010983893647789955, -0.032381899654865265, -0.016177061945199966, -0.023252736777067184, 0.004456952214241028, -0.0007008460815995932, 0.017139200121164322, 0.013229764066636562, -0.004334017168730497, 0.00949008297175169, 0.0032242881134152412, 0.014229899272322655, 0.003557870164513588, 0.005199931561946869, -0.012149755842983723, 0.001500801183283329, -0.010996174067258835, 0.004299209453165531, -0.020472468808293343, 0.0028602948877960443, 0.027884474024176598, 0.02192414551973343, 0.025729674845933914, -0.004866855219006538, -0.010534346103668213, -0.009829703718423843, 0.009043499827384949, 0.01265227235853672, -0.02081993594765663, -0.008637814782559872, -0.00954989530146122, -0.013786397874355316, -0.005448264069855213, -0.0048863934352993965, -0.014042207971215248, -0.03265957534313202, 0.01081712543964386, -0.0024428199976682663, 0.010268333368003368, 0.005891785956919193, -0.0033887780737131834, -0.03236410766839981, 0.006303406320512295, 0.00495360791683197, -0.00955429021269083, -0.014058258384466171, -0.0262402705848217, -0.014021184295415878, -0.020487675443291664, 0.0029359282925724983, 0.010522921569645405, -0.008814400061964989, -0.01042969711124897, -0.007653065957129002, -0.014311810955405235, 0.011788126081228256, -0.013979998417198658, -0.002658763201907277, 0.008402751758694649, 0.036451540887355804, -0.010837141424417496, 0.009937124326825142, 0.0018389044562354684, -0.008696703240275383, 0.007396165747195482, -0.014591902494430542, -0.008416924625635147, 0.025438405573368073, 0.006506806239485741, 0.02647995762526989, -0.006460196804255247, -0.00015005283057689667, 0.008547335863113403, -0.003108878619968891, 0.06684893369674683, 0.011393431574106216, -0.008619937114417553, -0.012449552305042744, 0.02240494266152382, -0.000010452233254909515, 0.0006327009759843349, -0.004380366764962673, -0.00011503184214234352, 0.012295767664909363, -0.03164537250995636, -0.0050444393418729305, 0.033134397119283676, -0.007849005982279778, 0.003931314684450626, 0.02873382903635502, 0.004722921177744865, 0.016748201102018356, 0.004446573555469513, -0.010061759501695633, 0.0006684418767690659, -0.011647181585431099, -0.010007437318563461, 0.009191581979393959, -0.007193875499069691, -0.023724179714918137, 0.005093355663120747, 0.026995396241545677, 0.003359027672559023, 0.01055939868092537, -0.015431591309607029, 0.011677125468850136, -0.004736197181046009, 0.017731893807649612, 0.0024369782768189907, -0.003700471017509699, -0.006425900850445032, 0.0007530041038990021, 0.0029544937424361706, 0.010175648145377636, -0.016945943236351013, 0.00007388531230390072, 0.004921722691506147, 0.016544140875339508, 0.007956699468195438, -0.022444186732172966, -0.02603776566684246, 0.00852813757956028, 0.013058631680905819, -0.0063669271767139435, 0.005584221798926592, -0.007713676895946264, 0.008767492137849331, -0.0066657885909080505, 0.00512267928570509, -0.01022419799119234, 0.007395646534860134, 0.011187061667442322, -0.03440648317337036, 0.01160511001944542, -0.017344094812870026, -0.007443641312420368, -0.03594931960105896, 0.036058459430933, 0.019026782363653183, 0.009318618103861809, -0.013050651177763939, 0.0022570695728063583, 0.01227196492254734, -0.006010662764310837, 0.023587774485349655, 0.006333732046186924, -0.0023995302617549896, -0.005256582051515579, -0.025403322651982307, 0.00825521256774664, 0.003389650257304311, 0.006209312938153744, -0.0014955783262848854, 0.026279577985405922, -0.03407710790634155, 0.01847492717206478, 0.010899554006755352, -0.026159098371863365, -0.00735723040997982, 0.003894257126376033, -0.020252134650945663, -0.020099936053156853, 0.003101193578913808, -0.0028464458882808685, -0.0032424351666122675, 0.006439163349568844, -0.021870996803045273, 0.0007234034710563719, -0.08132374286651611, -0.012096848338842392, 0.020414650440216064, -0.0005021867109462619, 0.008610637858510017, 0.015092332847416401, 0.012216050177812576, 0.026238424703478813, -0.011557488702237606, -0.018012747168540955, -0.00259607401676476, -0.010964822955429554, -0.012294677086174488, -0.007006456144154072, -0.01782260648906231, -0.0047941794618964195, 0.0034899841994047165, 0.0010810962412506342, -0.043599702417850494, 0.012353773228824139, -0.00988627877086401, -0.00485464371740818, 0.00365731050260365, -0.0014173549134284258, 0.008625385351479053, -0.016056936234235764, 0.02421608939766884, -0.005758808925747871, -0.009638371877372265, 0.009131303988397121, -0.02336675301194191, -0.020442210137844086, -0.018504725769162178, -0.008070297539234161, 0.012079678475856781, -0.031926900148391724, 0.0053091347217559814, -0.009364550933241844, -0.005787629168480635, 0.0024707606062293053, 0.01711845211684704, 0.005605792161077261, -0.008286301046609879, 0.003007194260135293, -0.000013566459529101849, -0.009217049926519394, 0.00929684191942215, 0.025306109338998795, 0.01897660829126835, 0.023832686245441437, -0.020478250458836555, -0.006786338519304991, 0.0005103512667119503, 0.004433739464730024, -0.011576028540730476, -0.00967647135257721, -0.011320414021611214, 0.014837232418358326, -0.010610956698656082, -0.004201722797006369, 0.010342005640268326, -0.03368523716926575, -0.01583695039153099, 0.034649573266506195, 0.027119219303131104, -0.006816805340349674, 0.002834002021700144, 0.004325940739363432, -0.003626883728429675, -0.007944694720208645, 0.018176449462771416, -0.009757280349731445, -0.005955202970653772, -0.0104089779779315, 0.03945757821202278, -0.012452207505702972, -0.012108776718378067, -0.007109834346920252, 0.02413870394229889, 0.0024738567881286144, -0.019942238926887512, -0.0032044718973338604, 0.00008770590648055077, -0.012946410104632378, -0.00460014957934618, 0.0413099080324173, 0.008619861677289009, -0.004185834433883429, 0.012149656191468239, -0.01693897508084774, -0.0007034345762804151, 0.017970893532037735, 0.0027284473180770874, 0.00885414145886898, 0.025865204632282257, 0.02577502653002739, 0.026358824223279953, -0.003885670332238078, -0.0011790748685598373, 0.011358384974300861, 0.0019183293916285038, 0.0080623310059309, -0.00439657224342227, -0.011011753231287003, -0.007925089448690414, 0.012762674130499363, -0.0022009359672665596, 0.010809676721692085, -0.012237914837896824, -0.008048096671700478, -0.0010635966900736094, -0.013758872635662556, -0.008995654992759228, 0.0025965161621570587, 0.008219389244914055, -0.01644379086792469, 0.006208752281963825, 0.036158472299575806, 0.07211962342262268, -0.0042939577251672745, 0.015798959881067276, -0.014757463708519936, 0.020279869437217712, -0.0022886437363922596, 0.010616702027618885, -0.013319695368409157, 0.016612719744443893, -0.018563557416200638, 0.013535858131945133, 0.020863546058535576, 0.003996254876255989, 0.006987918168306351, 0.0007833419367671013, -0.0154625428840518, -0.011584760621190071, 0.018988871946930885, -0.014897611923515797, -0.018555879592895508, -0.011993568390607834, 0.007305461913347244, 0.004359222948551178, 0.022166799753904343, 0.031742677092552185, -0.016578463837504387, -0.016244618222117424, -0.01351277343928814, -0.0009015174582600594, 0.006022590212523937, 0.02002347819507122, 0.03936373442411423, -0.005579435266554356, 0.008148625493049622, -0.005853084847331047, 0.024386778473854065, -0.012063395231962204, -0.010229744017124176, 0.011413387954235077, 0.0011737160384654999, -0.0037700089160352945, -0.009571122005581856, 0.03798047825694084, 0.008699041791260242, -0.00549772335216403, 0.003782216925173998, -0.009733612649142742, -0.003600984811782837, -0.01021024864166975, 0.004851979203522205, 0.0020257518626749516, 0.011962699703872204, 0.0114503875374794, -0.006166442763060331, -0.01755397766828537, 0.01129322499036789, -0.00173483625985682, -0.0043960558250546455, -0.0062887524254620075, 0.02171323262155056, 0.00196914654225111, -0.020804882049560547, 0.02441549487411976, -0.00041126832365989685, -0.001825942425057292, -0.007681730668991804, 0.007719704415649176, -0.0025350989308208227, 0.0037328393664211035, -0.003096354193985462, -0.022041410207748413, -0.006022836081683636, -0.01353389024734497, 0.02127567119896412, 0.011325294151902199, -0.001437340397387743, -0.0239579938352108, -0.01337430253624916, -0.010126587934792042, 0.014801429584622383, -0.025957712903618813, -0.006924912333488464, -0.008535662665963173, -0.015158263966441154, 0.006834050640463829, 0.012430250644683838, -0.010197050869464874, -0.07495295256376266, -0.0008879287634044886, 0.002632918767631054, -0.012725748121738434, -0.018058156594634056, 0.03953801840543747, -0.02580997161567211, 0.02179855853319168, -0.014039337635040283, -0.010886408388614655, -0.03683700039982796, 0.010026332922279835, -0.0258303452283144, -0.011187871918082237, 0.01473055500537157, 0.01791061833500862, -0.00427520927041769, 0.015840886160731316, 0.0195769090205431, 0.02029043436050415, 0.022063197568058968, -0.015449689701199532, -0.020931784063577652, -0.012051213532686234, 0.0013141848612576723, -0.08112578094005585, -0.005648911464959383, -0.005867959465831518, -0.009885890409350395, -0.025670256465673447, -0.01635812222957611, 0.01036769524216652, 0.009920235723257065, -0.006702433805912733, -0.016118131577968597, -0.024907538667321205, -0.01152118295431137, 0.029310502111911774, 0.0058490498922765255, -0.01755482703447342, -0.002948193810880184, 0.02213321253657341, -0.0007474555168300867, -0.017792977392673492, -0.008726700209081173, 0.020849082618951797, 0.007123073097318411, -0.008605710230767727, 0.018120842054486275, -0.003858244977891445, -0.009016555733978748, -0.024221079424023628, 0.005162463523447514, 0.021970240399241447, 0.006929146591573954, -0.0005895188078284264, -0.010833507403731346, -0.011867810972034931, -0.03735356777906418, -0.010321300476789474, -0.024168428033590317, 0.011267601512372494, -0.02362830936908722, -0.0030002095736563206, -0.01233676914125681, 0.0003311585169285536, -0.006095367483794689, 0.007597920019179583, 0.0035867937840521336, 0.01647774502635002, -0.005743001122027636, 0.00485953688621521, -0.0028421261813491583, 0.008088684640824795, -0.020936893299221992, 0.012586971744894981, 0.020642146468162537, 0.012519342824816704, -0.010459646582603455, 0.010438365861773491, -0.0043834904208779335, -0.011335831135511398, 0.019164586439728737, 0.01764627918601036, 0.00305043812841177, 0.010592692531645298, 0.010715887881815434, -0.007972132414579391, 0.07198773324489594, -0.013777730986475945, 0.010929528623819351, 0.005977601744234562, -0.013501154258847237, -0.005556686315685511, -0.008058084174990654, -0.009428413584828377, -0.0028736121021211147, -0.008682480081915855, -0.0002834009937942028, -0.009373072534799576, -0.002126672537997365, 0.01405397243797779, 0.016895323991775513, 0.0074587631970644, 0.018980761989951134, 0.015242623165249825, -0.002436783630400896, -0.0008217357099056244, 0.03835524618625641, 0.005804669111967087, -0.028898827731609344, 0.02883080020546913, 0.025708306580781937, -0.003681289032101631, 0.0002294234000146389, 0.02779291197657585, -0.007253540679812431, 0.01141735352575779, -0.018881898373365402, 0.017343290150165558, 0.004114239942282438, -0.01211654581129551, 0.011723811738193035, -0.009120245464146137, -0.005087685771286488, -0.0005140138091519475, -0.01731232926249504, 0.0021115578711032867, 0.026602424681186676, 0.009081179276108742, 0.014140668325126171, -0.02561916410923004, -0.01579219289124012, -0.01471572183072567, 0.013614852912724018, -0.03255428001284599, -0.005427416414022446, 0.0183367058634758, -0.009504318237304688, -0.005160730332136154, -0.02014501765370369, 0.01495017297565937, -0.014556683599948883, 0.009122882038354874, -0.006953278556466103, 0.01870039664208889, 0.021972157061100006, -0.017521999776363373, 0.0011639655567705631, -0.01266079768538475, 0.027078142389655113, -0.005393363069742918, -0.016559045761823654, 0.008068136870861053, 0.015103106386959553, -0.004626772366464138, -0.011918940581381321, 0.011230973526835442, 0.005383047740906477, -0.0021917219273746014, 0.006849783007055521, -0.012117389589548111, -0.003029897343367338, 0.0020762933418154716, 0.015623308718204498, -0.012113875709474087, 0.00019498594338074327, 0.000937808072194457, -0.016065437346696854, 0.009328339248895645, -0.01161554828286171, -0.013774688355624676, -0.007161506451666355, 0.008885779418051243, -0.0036824820563197136, 0.01320314034819603, -0.009848956018686295, -0.0013028528774157166, 0.013877181336283684, 0.007171064615249634, 0.008042147383093834, -0.006913376040756702, 0.005958016030490398, 0.03554508835077286, 0.0013509057462215424, 0.009841615334153175, -0.00003248918801546097, -0.004508849699050188, 0.0028295242227613926, 0.004660333506762981, -0.01075969822704792, 0.025572333484888077, 0.020061904564499855, -0.004635900724679232, 0.004621050786226988, 0.003083428367972374, -0.004909534938633442, 0.004764434415847063, -0.013727128505706787, -0.0023116329684853554, 0.01742739975452423, -0.003292851382866502, 0.006760368123650551, 0.01600535959005356, -0.0038317381404340267, -0.04959886521100998, 0.013133328408002853, -0.01792857050895691, 0.0033538751304149628, -0.015172543935477734, -0.00474757794290781, -0.0011169668287038803, 0.003454427234828472, -0.0327327586710453, -0.01186907198280096, -0.00532133411616087, 0.01860356330871582, 0.020334698259830475, 0.008522935211658478, -0.021081630140542984, 0.0009421143913641572, -0.01063753291964531, -0.009138327091932297, 0.01387258991599083, 0.0037789447233080864, 0.027683153748512268, -0.028324753046035767, 0.002258478431031108, 0.020980367437005043, -0.010364513844251633, 0.004770919680595398, -0.02192142978310585, 0.009427946992218494, -0.014727494679391384, 0.014792343601584435, 0.024443523958325386, 0.019437748938798904, 0.0019890645053237677, 0.003859718330204487, 0.013500666245818138, -0.010188151150941849, -0.008005158975720406, 0.009047325700521469, 0.027304835617542267, 0.008709034882485867, -0.02016468159854412, 0.002535182749852538, 0.0003690524026751518, -0.009543616324663162, 0.007465808652341366, -0.012754392810165882, 0.0029655443504452705, -0.018147263675928116, -0.019190942868590355, -0.009410850703716278, 0.006928515620529652, -0.013774383813142776, 0.014403825625777245, 0.010197898373007774, -0.03390255197882652, -0.023100068792700768, 0.018325012177228928, -0.015878504142165184, -0.002991179935634136, 0.021131606772542, 0.011406328529119492, -0.023586032912135124, 0.02542584016919136, 0.009568155743181705, -0.0017771266866475344, -0.011517848819494247, -0.017646895721554756, -0.015237069688737392, 0.02326551452279091, 0.00037760293344035745, -0.015847431495785713, 0.0032843635417521, 0.007582371588796377, -0.006162346340715885, -0.017337556928396225, -0.027793601155281067, -0.00723094679415226, -0.002489978913217783, -0.009236970916390419, -0.03818279504776001, 0.002059111837297678, 0.0036293843295425177, 0.007436325773596764, 0.008289333432912827, -0.02355067804455757 ]
[ 0.18470871448516846, -0.18095183372497559, -0.11758899688720703, 0.26252463459968567, -0.16156083345413208, 1.1531322002410889, 0.4636705219745636, 0.036220964044332504, -0.192356139421463, -0.22983209788799286, 0.022355254739522934, -0.22205552458763123, -0.22669397294521332, 0.1206589788198471, -0.3102700710296631, 0.6110600233078003, 0.5301885604858398, 0.22413770854473114, 0.0632462203502655, -0.07848633080720901, -0.2033873349428177, -0.0030270966235548258, 0.5380244255065918, 0.11612936109304428, -0.4905173182487488, -0.16768789291381836, 0.7057854533195496, -0.08714259415864944, -0.41213279962539673, 0.24327616393566132, -0.16409443318843842, 0.9290739893913269, -0.03757345303893089, -0.12911319732666016, -0.023157836869359016, 0.38218313455581665, -0.1323024034500122, -0.00873668771237135, 0.152500718832016, -0.6338978409767151, -0.03726884350180626, -0.1773717850446701, -0.07966256141662598, 0.5155622959136963, -0.3645439147949219, -0.1550069898366928, -1.0952433347702026, 0.6215223670005798, -0.42834094166755676, 0.11012043803930283, -0.3506041467189789, 0.39244866371154785, 0.5929728746414185, 0.020086033269762993, -0.521958589553833, -0.09381584078073502, -0.08084232360124588, 0.30998915433883667, 0.1993427723646164, -0.22897997498512268, 0.5944758653640747, -0.10194114595651627, 0.4525582492351532, 0.115239717066288, -0.09259630739688873, -0.09921851754188538, 0.1358230710029602, 0.06074809655547142, -0.005155994091182947, -0.42651763558387756, -0.11590337008237839, 0.1032569408416748, -0.26898330450057983, 0.15532532334327698, -0.28558793663978577, -0.0011541217099875212, -0.18017037212848663, -0.5444722175598145, 0.010834178887307644, -0.2503085732460022, 0.09904702752828598, -0.1788242757320404, 0.23783819377422333, -0.5162695646286011, 0.4374053180217743, -0.051759298890829086, 0.20337310433387756, 0.46869832277297974, -0.5107424855232239, 0.1912471354007721, -0.03561870753765106, 0.313100665807724, 0.8286280632019043, 0.43905454874038696, -0.40963467955589294, 0.07658415287733078, 0.1548422873020172, -0.1966751217842102, 0.010508192703127861, -0.4602445363998413, 0.3243783116340637, 0.26763153076171875, -0.13536232709884644, -0.12775921821594238, -0.6508128046989441, -0.5925184488296509, 0.24821630120277405, -0.4921906292438507, -0.2350359708070755, 0.1430092602968216, -0.8381938338279724, 0.2811598479747772, -0.03560977429151535, 0.09144408255815506, -0.22421705722808838, 0.19929131865501404, 0.1359752118587494, -0.1889638602733612, 0.08106936514377594, 0.194097638130188, -0.14001841843128204, 0.08150927722454071, -0.19579759240150452, -0.018933897837996483, 0.4101230204105377, -0.1262381225824356, 0.2701222598552704, -0.31345438957214355, -0.2503807842731476, 0.553936779499054, 0.38393518328666687, 0.11941451579332352, -0.3110911548137665, -0.007459130138158798, -0.32298389077186584, -0.2736273407936096, 0.3234301507472992, 0.026609713211655617, -0.19747090339660645, 0.10057099908590317, -0.36758074164390564, -0.35310494899749756, -0.5073636174201965, 0.06172819808125496, 0.12954233586788177, -0.5065507292747498, 0.11670933663845062, -0.13993854820728302, -0.26128870248794556, -0.13650505244731903, 0.09630782902240753, 0.24948900938034058, 0.16261929273605347, -0.38407576084136963, 0.22336597740650177, 0.33614906668663025, -0.37767043709754944, -0.32030797004699707, 0.32848605513572693, -0.15823687613010406, 0.5704757571220398, 0.566332221031189, 0.029074236750602722, 0.03358440846204758, 0.00017996162932831794, -0.3615851104259491, -0.02754899114370346, 0.681485652923584, -0.16112177073955536, 0.38050010800361633, -0.10090216249227524, 0.3186410069465637, 0.049334146082401276, -0.12444624304771423, -0.6268817186355591, 0.3163100481033325, 0.08054862171411514, 0.20588448643684387, 0.06337869167327881, 0.1514185070991516, -0.49624934792518616, -0.014347509481012821, 0.06769455224275589, 0.3599180579185486, 0.1738072633743286, 0.16121995449066162, 0.3697234094142914, -0.12599718570709229, -0.018977049738168716, 0.0931776911020279, -0.37536290287971497, -0.5765764117240906, 0.30193519592285156, -0.13787105679512024, 0.9773451089859009, -0.1955954134464264, -0.25726261734962463, 0.9516542553901672, 0.2614886164665222, -0.3477059602737427, -0.16028127074241638, -0.540016233921051, 0.29945603013038635, 0.16990819573402405, -0.023051735013723373, 0.1687556803226471, -0.2849395275115967, 0.018580421805381775, -0.4544253647327423, 0.24126549065113068, -0.10449047386646271, -0.6891754269599915, -0.16676782071590424, 0.051543593406677246, -0.006105201784521341, 0.08189168572425842, -0.28021472692489624, 0.3571896553039551, 0.2354474812746048, 0.17252391576766968, 0.870105504989624, -0.36651211977005005, 0.2903364598751068, 0.13856936991214752, 0.09740214049816132, -0.237853541970253, 0.5041242241859436, 0.49957147240638733, 0.3728911578655243, -0.6968804597854614, -0.16020996868610382, 0.01663156785070896, 0.4737284183502197, -0.061013493686914444, -0.01778092421591282, 0.28387004137039185, -0.36459651589393616, 0.061135292053222656, 0.35869747400283813, -0.594305157661438, -0.1664106398820877, -0.04991300776600838, 0.31201913952827454, 0.33528491854667664, -0.026554524898529053, -0.21723778545856476, -0.30102112889289856, 0.389941543340683, -0.8172696232795715, 0.045021358877420425, 0.014068368822336197, 0.364127516746521, -0.050741046667099, 0.35378196835517883, 0.11682300269603729, 0.25283050537109375, 0.450102299451828, -0.3198803961277008, 0.019500629976391792, -0.3740925192832947, -0.0742098018527031, 0.24740010499954224, 0.2124069780111313, 0.034272193908691406, 0.42651039361953735, -0.6882445216178894, -0.8294453620910645, -0.597919225692749, 0.4273707866668701, 0.39256390929222107, 0.7657890915870667, -0.022576844319701195, -0.4901362657546997, 0.23911358416080475, 0.04090997949242592, -0.6495991349220276, 0.27492469549179077, 0.7270843386650085, -0.7772682905197144, -0.4147542715072632, 0.007813196629285812, 0.32073333859443665, 0.8384951949119568, -0.3348644971847534, 0.46465572714805603, -0.18055053055286407, -0.17173461616039276, -0.19493545591831207, -0.03366708755493164, -0.3235534727573395, 0.35701465606689453, 0.6162261962890625, -0.052359018474817276, -0.36056748032569885, -0.07813290506601334, 0.7774040102958679, -0.20625898241996765, 0.25366008281707764, 0.7324773669242859, 0.1621871143579483, -0.10141932219266891, 0.06040346622467041, -0.13552361726760864, 0.030049992725253105, -0.11647612601518631, -0.1666240096092224, -0.29238325357437134, 0.1575646847486496, -6.301316261291504, 0.3711879849433899, -0.22540071606636047, -0.10734432935714722, 0.035093195736408234, 0.18519797921180725, 0.9578399658203125, 0.022312847897410393, -0.18474841117858887, -0.1046672910451889, 0.18882660567760468, 0.17617283761501312, -0.025981580838561058, 0.2416314035654068, 0.18039490282535553, 0.34227660298347473, 0.36893603205680847, -0.18435807526111603, 0.013635009527206421, 0.17685872316360474, 0.0012688928982242942, -0.2146933376789093, 0.02836429327726364, 0.2819661796092987, 0.1465485692024231, 0.4072932004928589, -0.2881677448749542, 0.04634242504835129, -0.39411041140556335, -0.3157549798488617, -0.4388853907585144, -0.5596647262573242, -0.21428123116493225, 0.17765623331069946, 0.8392836451530457, 0.05006726086139679, 0.1058003380894661, 0.4549359679222107, 0.15241658687591553, -0.16342556476593018, -0.34348341822624207, 0.6296013593673706, 0.004530847538262606, -0.3220313787460327, 0.2504344880580902, 0.156225323677063, 0.1695966273546219, 0.08410069346427917, -0.6871533393859863, 0.31861358880996704, 0.24872618913650513, -0.10037335008382797, 0.08969167619943619, 0.402176171541214, 0.05425774306058884, -0.07464643567800522, 0.03161777928471565, 0.4204074740409851, -0.2983626425266266, 0.23240098357200623, -0.05261443555355072, 0.11329741775989532, 0.20979095995426178, -1.1462427377700806, 0.2737199366092682, 0.12448475509881973, -0.6351072788238525, -0.33352088928222656, -0.020429521799087524, 0.15209424495697021, -0.1999446451663971, -0.2280140221118927, 0.02536754682660103, -0.8213773369789124, 0.01234764140099287, -0.6005854606628418, 0.025643402710556984, -0.009783239103853703, 0.1357421725988388, -0.08897764980792999, -0.2299959808588028, -0.28574132919311523, 0.13334034383296967, -0.000847826711833477, 0.2670457661151886, -0.12945227324962616, 0.16813896596431732, 0.0638670027256012, -0.2650516629219055, 0.053671929985284805, 0.18018858134746552, -0.4308023154735565, 0.10160137712955475, 0.03433516249060631, 0.25866690278053284, 0.5817869305610657, 0.07061579078435898, -0.1278303563594818, 0.18606239557266235, -0.02495068497955799, 0.07382240146398544, -0.20698140561580658, -0.16164642572402954, -0.6442540287971497, 0.10811895877122879, 0.3182697594165802, -0.5019298195838928, 0.4721200168132782, 0.8690049052238464, -0.9918259978294373, 0.02348063699901104, 0.1646258682012558, 0.09748715162277222, -0.631987988948822, 0.8628749847412109, -0.10085131973028183, -0.09910007566213608, 0.520327091217041, 0.08904526382684708, 0.14368852972984314, -0.0020388104021549225, -0.16621270775794983, -0.5650217533111572, 0.15489797294139862, -0.4909188449382782, -0.24358949065208435, -0.35230156779289246, 0.17305655777454376, -0.5600106120109558, 0.4244694709777832, 0.48910918831825256, 0.5701562166213989, -0.029933840036392212, -0.19658388197422028, 0.31257495284080505, -0.047675520181655884, -0.11437907814979553, 0.09559367597103119, -0.3010038733482361, -0.29331567883491516, -0.2229151576757431, 0.02879360504448414, 0.17210990190505981, -0.1618635207414627, 0.1823449730873108, -0.17656445503234863, -0.027244435623288155, -0.42542141675949097, -0.09509610384702682, -0.2559407353401184, -0.07470974326133728, 0.02258540689945221, -0.17296522855758667, 0.45142170786857605, -0.43692445755004883, 0.2753658890724182, 0.6940352916717529, 0.14617754518985748, -0.12724275887012482, -0.44024765491485596, 0.36230918765068054, -0.25071972608566284, -1.3841334581375122, -0.0031528426334261894, 0.4218153953552246, -0.5329960584640503, -0.09806416183710098, 0.0013884060317650437, 0.26160451769828796, 0.42038044333457947, 0.4752506613731384, -0.4652864634990692, 0.07234444469213486, 0.227853924036026, -0.14360181987285614, -0.022094840183854103, -0.35296395421028137, -0.006481102667748928, -0.11950105428695679, 0.4144378900527954, 0.06883184611797333, -0.10636507719755173, -0.3008289039134979, -0.08577041327953339, 0.23943063616752625, 0.24891693890094757, -0.3146922290325165, -0.08940717577934265, 0.11047016084194183, -0.23515193164348602, 0.19837048649787903, -0.28387805819511414, 0.3067009449005127, -0.00003433932943153195, -0.2490323781967163, -0.17768219113349915, 0.07426577061414719, 0.3846410810947418, -0.3326821029186249, 0.29183831810951233, -0.11421678215265274, 0.05219058692455292, -0.4501759111881256, -0.10198893398046494, 0.42778870463371277, -0.2675175070762634, 0.27627047896385193, 0.12944883108139038, -0.24854901432991028, -0.10222118347883224, -0.905385434627533, -0.32377344369888306, -0.5577144026756287, 0.3238661289215088, -0.12382228672504425, -0.1354219615459442, -0.06277281045913696, -0.8519913554191589, -0.5159276723861694, -0.0030188860837370157, 0.16460329294204712, 0.09727173298597336, -0.412942498922348, -0.25478196144104004, -0.29399460554122925, -0.5288217067718506, 0.16211913526058197, -0.6106507182121277, -0.372188001871109, 0.18812498450279236, -0.1735365092754364, 0.14374510943889618, 0.4505414366722107, 0.321885883808136, -0.5387594103813171, -0.4158148467540741, -0.213518887758255, -0.18883520364761353, -0.1087595596909523, 0.2476911097764969, -0.15317729115486145, 0.09664582461118698, 0.1285761147737503, -0.21302810311317444, 0.6043000817298889, -0.020297233015298843, 0.2098907083272934, -0.13310255110263824, 0.20258384943008423, 0.04704936221241951, 0.0021447634790092707, -0.40873149037361145, -0.3072934150695801, -0.2746948003768921, 0.3894330859184265, 0.1546260565519333, 0.07387486100196838, -0.39789384603500366, 0.2634181082248688, 0.48670631647109985, -0.3693923056125641, -0.10632359981536865, 0.36180081963539124, 0.014988581649959087, -0.2971799671649933, 0.2087443470954895, 0.1205490306019783, -0.38085439801216125, -0.049366388469934464, -0.45319515466690063, 0.5911357402801514, 0.09308181703090668, 0.2593742907047272, -0.0831701010465622, 0.10808413475751877, -0.07727288454771042, -0.0953993871808052, 0.40373727679252625, -0.06805207580327988, 0.14369608461856842, -0.4250446557998657, -0.20426589250564575, -0.1336727887392044, 0.00016480876365676522, 0.2561470866203308, -0.4624731242656708, 0.29646947979927063, -0.16158942878246307, -0.3427325189113617, -0.2425856590270996, -0.09320325404405594, -0.10508063435554504, -0.5196434855461121, -0.21986685693264008, -0.2674332559108734, -0.06157198175787926, 0.2168499380350113, 0.5038401484489441, -0.25831520557403564, -0.01091412641108036, -0.5094499588012695, 0.1951146274805069, 0.15134510397911072, -0.1345357447862625, 0.2343350052833557, 0.03113674931228161, 0.2863209545612335, -0.24402247369289398, -0.08493521064519882, 0.1582563817501068, 0.47070935368537903, 0.03590507432818413, 0.5631586909294128, 0.3271321952342987, -0.5328905582427979, -0.24419201910495758, -0.23892128467559814, 0.09276710450649261, 0.14971627295017242, 0.046004604548215866, 0.033837344497442245, 0.26559266448020935, 0.6705466508865356, 0.1728307008743286, -0.018373338505625725, 0.48234307765960693, 0.3423040807247162, -0.08170539885759354, 0.4433808922767639, 0.7206640839576721, 0.498317152261734, 0.7605542540550232, -0.03228211775422096, 0.17330139875411987, 0.07370251417160034, 0.05747266113758087, -0.13210295140743256, -0.24555304646492004, -0.0881456658244133, 0.1479458063840866, 0.7579001188278198, -0.08184638619422913, -0.08954378217458725, 0.03557341918349266, 0.2833951711654663, 0.32821232080459595, 0.03676040098071098, 0.18311430513858795, 0.05017588660120964, 0.04407067969441414, 0.412106454372406, -0.20607657730579376, -0.09219745546579361, 0.36223506927490234, -0.13827849924564362, 0.22697119414806366, 0.3877217173576355, -0.33085834980010986, -0.688174307346344, 0.06486727297306061, 0.20010551810264587, 0.033266499638557434, -0.33913105726242065, -0.13967464864253998, 0.2446904182434082, -0.19124047458171844, 0.21952205896377563, 0.14075134694576263, -0.2038775384426117, -0.49304261803627014, 0.14723306894302368, -0.09487360715866089, -0.2896423935890198, 0.12294622510671616, 0.033940352499485016, -0.011477287858724594, 0.3161320686340332, 0.0575285367667675, 0.35002264380455017, 0.20557041466236115, -0.029295720160007477, -0.125111922621727, 0.07005389779806137, -0.5117776989936829, -0.5157167911529541, 0.2498868703842163, -0.22871650755405426, -0.014916391111910343, 0.5687985420227051, 0.29619258642196655, -0.12879960238933563, -0.3427381217479706, -0.04868093132972717, 0.48779037594795227, -0.203831285238266, -0.06696448475122452, -0.5585393905639648, 0.2050953060388565, 0.4543803632259369, 0.172264963388443, 0.11096512526273727, -0.300067663192749, -0.5910300612449646, 0.3896172344684601, -0.178340345621109, 0.41685062646865845, -0.24272111058235168, -0.09747561812400818, -0.39084911346435547, 0.2324805110692978, 0.2209526002407074, -0.12414228916168213, 0.10909073799848557, 0.260107159614563, -0.18817314505577087, 0.4402160048484802, 0.5770207047462463, -0.3759225606918335, -0.025218166410923004, -0.6894882321357727, -0.38910070061683655, -0.6232486367225647, 0.16484136879444122, -0.4275994300842285, -0.2826235592365265, 0.5021275281906128, -0.009622709825634956, 0.14102523028850555, -0.42090922594070435, 0.6617587804794312, -0.37097465991973877, -0.10819929093122482, 0.06978697329759598, 0.04102855548262596, -0.931271493434906, 0.36184242367744446, 0.2740406394004822, 0.21621815860271454, -0.08344010263681412, -0.5368755459785461, -0.39251863956451416, -0.6128754019737244, 0.18798187375068665, 0.6302478313446045, 0.504357099533081, 0.12534189224243164, -0.16591256856918335, 0.20704209804534912, -0.29787972569465637, 0.01420154981315136, -0.17815010249614716, -0.22518926858901978, 0.027798814699053764, 0.027534250169992447, -0.04170392453670502, -0.21317435801029205, 0.15336555242538452, -0.6181631684303284, -0.013687457889318466, 0.13126502931118011 ]
Integrins regulate adhesion-dependent growth, survival and invasion of tumor cells. In particular, expression of integrin alpha(v)beta(3) is associated with progression of a variety of human tumors. Here we reveal a previously undescribed adhesion-independent role for integrin alpha(v)beta(3) in pancreatic cancer and other carcinomas. Specifically, alpha(v)beta(3) expressed in carcinoma cells enhanced anchorage-independent tumor growth in vitro and increased lymph node metastases in vivo. These effects required recruitment of c-Src to the beta(3) integrin cytoplasmic tail, leading to c-Src activation, Crk-associated substrate (CAS) phosphorylation and tumor cell survival that, unexpectedly, was independent of cell adhesion or focal adhesion kinase (FAK) activation. Pharmacological blockade of c-Src kinase activity or decreased expression of endogenous alpha(v)beta(3) integrin or c-Src not only inhibited anchorage-independent growth but also suppressed metastasis in vivo, yet these manipulations did not affect tumor cell migration or invasion. These data define an unexpected role for an integrin as a mediator of anchorage independence, suggesting that an alpha(v)beta(3)-c-Src signaling module may account for the aggressive behavior of integrin alpha(v)beta(3)-expressing tumors in humans.
[ -0.03224693983793259, 0.017262902110815048, -0.01762218400835991, 0.009130913764238358, 0.028958039358258247, -0.037042953073978424, 0.011912915855646133, -0.01416082214564085, -0.013041766360402107, 0.008297469466924667, -0.011490117758512497, 0.012753036804497242, -0.015516372397542, 0.030000556260347366, -0.010870634578168392, 0.018118973821401596, -0.004231421742588282, -0.03670177608728409, 0.0013301700819283724, -0.006139603443443775, 0.004399031400680542, -0.016207698732614517, 0.010621052235364914, 0.01551620289683342, 0.01233997568488121, -0.008176494389772415, 0.01937420666217804, -0.004275248385965824, -0.020641453564167023, -0.009080297313630581, 0.011585348285734653, -0.0031752344220876694, 0.01924186386168003, -0.0030085917096585035, 0.0062393611297011375, -0.008438180200755596, -0.006473216228187084, 0.020060252398252487, -0.001724748406559229, -0.0057116406969726086, -0.00026233214884996414, -0.008877079002559185, -0.0036534839309751987, 0.012606529518961906, -0.008270940743386745, -0.03251964598894119, -0.000247871590545401, 0.002618228318169713, -0.0029489921871572733, 0.0034859732259064913, -0.014127083122730255, -0.01251077651977539, -0.011725223623216152, -0.01920963265001774, -0.006562874652445316, -0.011072597466409206, 0.018092969432473183, -0.010898747481405735, -0.026454126462340355, 0.02397874929010868, -0.007403228897601366, -0.026946648955345154, 0.025922339409589767, -0.02991684153676033, 0.0025863375049084425, -0.0670199990272522, -0.00039342697709798813, -0.023974565789103508, -0.0012667608680203557, 0.01966048590838909, -0.0020730444230139256, 0.008722025901079178, 0.0345374196767807, 0.007469025440514088, -0.020511258393526077, -0.009285061620175838, -0.004826943390071392, 0.011519749648869038, 0.03203405812382698, -0.019971339032053947, 0.0023957984521985054, 0.0032646500039845705, 0.013938388787209988, -0.000914346135687083, 0.03351321071386337, -0.0009792190976440907, -0.01747371442615986, -0.007218488957732916, 0.038543712347745895, -0.01030481792986393, 0.020773325115442276, 0.012742547318339348, 0.0032798396423459053, -0.011332213878631592, 0.014738466590642929, 0.01432205829769373, -0.001134186051785946, -0.02425209805369377, 0.010975541546940804, 0.010035979561507702, -0.028582226485013962, -0.020405126735568047, 0.017594758421182632, -0.00017387350089848042, 0.007832476869225502, 0.00945292878895998, -0.02320229820907116, 0.03171239048242569, 0.013324683532118797, 0.012611094862222672, -0.028920061886310577, -0.002054784446954727, 0.003985442221164703, 0.011066972278058529, 0.001674056053161621, -0.008904341608285904, -0.02563101053237915, -0.011661509051918983, 0.016270602121949196, -0.02242705225944519, 0.007498131133615971, -0.004861438646912575, 0.002997089410200715, -0.01484544388949871, 0.0011677477741613984, 0.00621339026838541, 0.01051846332848072, 0.007140999659895897, -0.02323247119784355, 0.011388191021978855, -0.010360807180404663, 0.029004424810409546, -0.01459121610969305, 0.015656214207410812, 0.02634544111788273, 0.0030621779151260853, -0.027031313627958298, -0.0073462966829538345, -0.010946371592581272, -0.016267264261841774, 0.011863413266837597, 0.012789206579327583, 0.0019361247541382909, 0.00793200172483921, 0.013694947585463524, 0.01455404981970787, -0.026948604732751846, -0.0033862332347780466, -0.017346343025565147, -0.013688571751117706, -0.009737709537148476, -0.003833024762570858, 0.0035607796162366867, -0.021472670137882233, 0.03488217666745186, 0.026546712964773178, -0.0029074442572891712, -0.03351522982120514, 0.002409874927252531, -0.0027313861064612865, -0.027825336903333664, -0.03009890951216221, 0.01508395653218031, 0.008091784082353115, 0.000503739807754755, 0.004433084279298782, 0.013037066906690598, -0.009669964201748371, 0.00635866355150938, 0.0073360721580684185, -0.004333483055233955, -0.011994684115052223, 0.028457017615437508, 0.007251153700053692, -0.035825446248054504, 0.0011750995181500912, 0.003251480869948864, 0.006566145457327366, -0.014443820342421532, 0.06697233021259308, -0.004261179361492395, 0.007307735271751881, -0.004372498951852322, 0.011576950550079346, -0.005731626879423857, -0.0015219829510897398, 0.02132304199039936, -0.00580065231770277, -0.002312691183760762, -0.008059561252593994, -0.012384663335978985, -0.005488055758178234, -0.015916958451271057, 0.011451631784439087, -0.012052018195390701, 0.004259008914232254, 0.02929573878645897, 0.009660052135586739, -0.0004519431386142969, -0.00006326381117105484, 0.01680903509259224, -0.027055803686380386, 0.017766665667295456, -0.029780283570289612, 0.004735124297440052, 0.006999575532972813, -0.0012564276112243533, -0.009693548083305359, -0.030857786536216736, -0.010455401614308357, 0.02526991069316864, -0.03204267844557762, -0.020666832104325294, 0.00015039904974400997, 0.0003427225165069103, 0.01678251475095749, -0.005262297578155994, 0.003963931929320097, -0.014047439210116863, -0.012679627165198326, 0.000717675662599504, 0.017625069245696068, 0.015792682766914368, -0.011256217956542969, 0.035878442227840424, 0.013890275731682777, -0.0011641313321888447, 0.014604217372834682, 0.014707457274198532, -0.013110566884279251, -0.022177068516612053, -0.016566753387451172, -0.013383746147155762, -0.004989867098629475, 0.007795339450240135, -0.010805420577526093, 0.0139522235840559, -0.0115238968282938, 0.032810941338539124, -0.006136937998235226, -0.013897377997636795, 0.011270268820226192, 0.021766947582364082, 0.015197008848190308, 0.0374273955821991, 0.002046799985691905, -0.02713881805539131, -0.003988474141806364, 0.022535793483257294, -0.04345138370990753, 0.008290342055261135, -0.016945037990808487, -0.001428096555173397, -0.02700081840157509, -0.03218080848455429, -0.0038947665598243475, -0.0003121779300272465, -0.006183010991662741, 0.0241873636841774, 0.019301455467939377, -0.00009005260653793812, 0.01015128381550312, -0.010859698057174683, 0.02442079409956932, -0.0020147438626736403, 0.016164589673280716, -0.01738746091723442, 0.030566398054361343, 0.011178374290466309, 0.004869788885116577, 0.008617212064564228, -0.002092846669256687, -0.00236028921790421, -0.08107556402683258, -0.013886797241866589, -0.014301063492894173, 0.01564515195786953, 0.010689091868698597, -0.01905887946486473, 0.017629200592637062, 0.003955165855586529, -0.0020270932000130415, 0.007507189176976681, -0.0006401743739843369, 0.01489773765206337, -0.011557185091078281, -0.021361807361245155, -0.008268640376627445, 0.0025027950759977102, 0.007258051075041294, -0.0028407848440110683, -0.0014838408678770065, -0.01537923514842987, 0.021294549107551575, 0.020507587119936943, 0.007059298921376467, -0.013012044131755829, -0.01792045310139656, 0.039734162390232086, -0.020229436457157135, 0.002924064639955759, -0.0290219783782959, 0.0023636617697775364, -0.005568537395447493, -0.03364873304963112, -0.01649162918329239, 0.011529702693223953, 0.015735827386379242, 0.0011926442384719849, -0.006062707863748074, -0.034521859139204025, -0.003601063508540392, 0.018213536590337753, -0.016249435022473335, 0.02289082296192646, 0.01612778566777706, 0.008517209440469742, 0.023205434903502464, 0.00482475059106946, -0.02453366108238697, 0.04841777682304382, 0.021511264145374298, -0.006817260757088661, 0.047101836651563644, 0.008008213713765144, 0.007796555757522583, 0.027688857167959213, -0.018058311194181442, -0.011869295500218868, 0.007742386311292648, -0.013927512802183628, -0.009320957586169243, 0.006464873440563679, -0.004271082580089569, -0.005042617674916983, 0.0038650520145893097, -0.006760282441973686, -0.011242489330470562, 0.021272197365760803, 0.009970815852284431, 0.0038755140267312527, -0.03136250376701355, 0.012699813582003117, 0.028503352776169777, -0.005275634117424488, 0.03371081501245499, -0.011336497031152248, 0.0021695701871067286, -0.007474320940673351, -0.013216711580753326, -0.00550839863717556, -0.003207440720871091, -0.004843021742999554, -0.008343968540430069, 0.0000221078225877136, -0.021075980737805367, 0.010486945509910583, -0.008574157021939754, -0.018211815506219864, 0.007434624247252941, 0.030905291438102722, 0.00910451915115118, -0.01855681836605072, 0.01066930778324604, 0.0352717861533165, 0.0010186564177274704, 0.011427226476371288, 0.021536702290177345, -0.03371000289916992, 0.023344948887825012, -0.005465031135827303, 0.018529396504163742, 0.009327968582510948, -0.023358739912509918, -0.0026625008322298527, -0.017908556386828423, -0.01684425212442875, -0.05087645351886749, 0.014033621177077293, 0.006520004011690617, -0.01163405366241932, -0.005776572972536087, -0.002773369662463665, -0.008655914105474949, -0.024493128061294556, -0.012352813966572285, 0.03659062832593918, 0.011920713819563389, 0.034145914018154144, -0.005050858482718468, -0.01238897442817688, 0.07206542789936066, 0.020694829523563385, -0.013437919318675995, -0.009651122614741325, 0.044911690056324005, -0.01926090568304062, -0.028610609471797943, 0.015957050025463104, 0.027234848588705063, -0.00541023351252079, 0.011805292218923569, -0.006157200783491135, 0.030606914311647415, -0.008462785743176937, -0.017161961644887924, 0.02140449732542038, -0.010936696082353592, 0.013823386281728745, 0.036415182054042816, -0.019094668328762054, -0.03301055729389191, -0.002735851565375924, -0.005944668315351009, 0.005692193750292063, 0.010067473165690899, -0.03380527347326279, 0.01662127673625946, -0.016772426664829254, -0.02686670795083046, 0.007162050809711218, 0.012814367190003395, -0.03923895210027695, -0.00667200330644846, -0.015766218304634094, 0.01667768694460392, 0.010694285854697227, 0.00897233933210373, -0.029230231419205666, -0.016395200043916702, -0.017245035618543625, 0.02028709650039673, -0.012965504080057144, 0.018077515065670013, 0.014765040948987007, 0.0009575991425663233, 0.009671533480286598, 0.01691303960978985, -0.01202873233705759, -0.0052629681304097176, -0.008140980266034603, -0.02875681035220623, 0.007697392255067825, 0.01397244818508625, -0.014429542236030102, -0.017311863601207733, 0.020884055644273758, -0.002146657556295395, -0.005084758158773184, 0.0007223444990813732, -0.008827995508909225, -0.03729937970638275, 0.007101666182279587, 0.017976313829421997, -0.02282903902232647, -0.0014622397720813751, -0.009142333641648293, 0.006898093968629837, -0.010793160647153854, 0.0025681299157440662, -0.015476861968636513, 0.014828365296125412, -0.004340632818639278, -0.04773882403969765, -0.0011016721837222576, -0.02232692576944828, -0.005124579183757305, 0.007897146046161652, -0.03338351100683212, 0.029301900416612625, -0.018674295395612717, -0.0009322194382548332, 0.005043894983828068, 0.0003405289025977254, -0.00012444984167814255, -0.008596536703407764, -0.0017446374986320734, 0.0020453534089028835, -0.07457966357469559, -0.00575401121750474, -0.009540533646941185, -0.00979529321193695, -0.029141532257199287, 0.014060731045901775, -0.016195589676499367, -0.023674797266721725, -0.020696349442005157, -0.01082904078066349, 0.02298852801322937, -0.0039842878468334675, 0.013515543192625046, 0.00784943625330925, 0.011754697188735008, 0.010114846751093864, -0.015777762979269028, -0.018103379756212234, -0.003359077963978052, -0.011810068041086197, -0.010217749513685703, -0.03531353920698166, -0.012574950233101845, -0.008308446034789085, -0.0073092286475002766, -0.08067083358764648, 0.004744017496705055, -0.009646079502999783, -0.011123389936983585, 0.01628914289176464, 0.007743603549897671, 0.024663953110575676, 0.004953757394105196, -0.019749954342842102, -0.016874708235263824, 0.0026861857622861862, -0.011937612667679787, -0.013608725741505623, -0.0018484005704522133, -0.010119921527802944, -0.008556578308343887, 0.011029299348592758, -0.007889569737017155, -0.01596076413989067, -0.03441683202981949, 0.014925061725080013, 0.024753842502832413, -0.008225932717323303, -0.0045430706813931465, -0.007751109078526497, -0.02120576612651348, -0.01906685158610344, 0.019535675644874573, -0.01189406868070364, -0.006450471468269825, -0.00795007310807705, -0.017206352204084396, -0.016709037125110626, -0.022624962031841278, -0.029700640588998795, -0.027058793231844902, 0.01308473851531744, -0.0162285715341568, 0.009146353229880333, -0.026818403974175453, -0.004684234503656626, 0.014855175279080868, -0.02638239786028862, 0.03972628712654114, -0.006434358656406403, 0.017503771930933, 0.006479612085968256, -0.0032978509552776814, 0.002205409575253725, -0.013336140662431717, 0.01038365624845028, 0.010425278916954994, -0.0027944562025368214, -0.009020552039146423, -0.0028044353239238262, -0.01626615598797798, -0.0027905902825295925, -0.00907362811267376, 0.012371048331260681, 0.009851481765508652, -0.0005395562038756907, 0.0020642585586756468, 0.015666712075471878, 0.07215346395969391, 0.016522709280252457, 0.015470286831259727, -0.02109813317656517, 0.009459464810788631, -0.0023778851609677076, -0.0038410499691963196, 0.004854009952396154, 0.0014296465087682009, -0.019899491220712662, -0.00034109712578356266, -0.018870584666728973, 0.0010219290852546692, 0.013613383285701275, -0.014395073056221008, 0.008411506190896034, 0.023310700431466103, 0.023076754063367844, 0.00028540659695863724, 0.0005739424377679825, 0.001991074299439788, -0.02349787950515747, -0.02949780970811844, -0.010046470910310745, -0.0016143317334353924, -0.003875388763844967, 0.0006887074559926987, -0.009371321648359299, 0.0020127426832914352, 0.004294193349778652, 0.013872954063117504, 0.022443711757659912, -0.0049803247675299644, -0.027700992301106453, 0.025607429444789886, 0.026230864226818085, -0.009542107582092285, 0.009943116456270218, -0.006085676606744528, -0.007173151709139347, 0.012532065622508526, 0.00219979090616107, 0.003824979066848755, -0.013726219534873962, 0.014075277373194695, -0.01718190684914589, -0.00337577098980546, -0.02072080224752426, -0.04875091090798378, 0.013426168821752071, -0.014934933744370937, -0.008492453023791313, -0.003041581716388464, 0.010837479494512081, 0.01700885407626629, -0.0059386203065514565, 0.012434261851012707, 0.005068834871053696, -0.025663698092103004, -0.025134164839982986, -0.0036671701818704605, -0.01191178523004055, -0.012314597144722939, -0.018999546766281128, 0.04152563586831093, 0.02726157009601593, 0.03414531797170639, -0.02137751691043377, -0.005053570028394461, 0.019931059330701828, -0.014079190790653229, -0.005801443941891193, 0.011670378968119621, 0.0056006209924817085, 0.003953258506953716, 0.008351137861609459, 0.010389123111963272, -0.0053769126534461975, 0.01577000692486763, 0.0021397939417511225, -0.007617505267262459, 0.023197144269943237, 0.0002427631989121437, 0.01021043211221695, -0.024644089862704277, 0.0013685578014701605, 0.0023170923814177513, -0.019280657172203064, -0.002024505054578185, 0.006473822519183159, 0.02840418741106987, -0.009421196766197681, 0.005241371225565672, 0.00828227587044239, 0.0079567302018404, 0.034178271889686584, -0.01123424805700779, 0.0016601078677922487, -0.048879753798246384, -0.0032423604279756546, 0.007984470576047897, -0.0007458201143890619, -0.011180787347257137, 0.019987743347883224, -0.010032592341303825, -0.009748874232172966, 0.01742992363870144, -0.007354720961302519, 0.010425876826047897, 0.035505279898643494, -0.010457731783390045, -0.00431485241279006, 0.008257458917796612, -0.007407838013023138, -0.0023289674427360296, 0.05646773427724838, -0.018323857337236404, -0.016447465866804123, -0.0008317481260746717, -0.014004630036652088, -0.013993296772241592, 0.017018651589751244, -0.024100717157125473, 0.0076186684891581535, -0.022626319900155067, -0.01195488777011633, -0.00996163859963417, 0.008470824919641018, 0.00829628948122263, -0.005863116588443518, 0.03443478047847748, -0.02049567922949791, -0.0008725998923182487, 0.012881136499345303, -0.014171192422509193, 0.016421521082520485, -0.004532234743237495, 0.007575222756713629, 0.0053585851565003395, 0.026590337976813316, 0.013863330706954002, -0.02818155288696289, 0.0005441815592348576, 0.03547884523868561, 0.008198164403438568, 0.006322436034679413, 0.03450745344161987, -0.004325447604060173, 0.007124144583940506, -0.020864054560661316, -0.004106253385543823, 0.011727842502295971, 0.0048682233318686485, -0.0038496246561408043, -0.02423960715532303, 0.01705772802233696, 0.0007189277675934136, -0.015615049749612808, -0.004918225109577179, -0.005633658729493618, 0.0013987310230731964, -0.026030972599983215, 0.014669083058834076, -0.0028591835871338844, 0.0165569931268692, -0.0009447522461414337, 0.004520296584814787, -0.00668888445943594, -0.027010949328541756, -0.004955075215548277, 0.031198615208268166, 0.02329160086810589, -0.008129702880978584, 0.028230151161551476, -0.03049996867775917, -0.011463294737040997, -0.011683136224746704, -0.002405619015917182, -0.007699221838265657, -0.009647384285926819, -0.004631992429494858, -0.024097658693790436, 0.016535189002752304, -0.007171685807406902, 0.01607712171971798, -0.006013842299580574, -0.0033520045690238476, 0.0036407210864126682, -0.008127936162054539, -0.009445598348975182, 0.003368120640516281, -0.018942585214972496, -0.005891249515116215, 0.012978591956198215, -0.034971848130226135, 0.011393271386623383, -0.009344427846372128, 0.02591555565595627, -0.0018798967357724905, -0.0031293993815779686, 0.030700715258717537, -0.004714450798928738 ]
[ -0.45432746410369873, 0.10207299888134003, 0.442586749792099, -0.13062387704849243, -0.5074272155761719, 0.5286402106285095, 0.11963313072919846, -0.5247912406921387, 0.20548537373542786, -0.5499016046524048, 0.19499942660331726, 0.5035927891731262, -0.6018532514572144, 0.267421692609787, 0.05283185839653015, 0.6866915225982666, 0.37378978729248047, 0.7409763336181641, -0.09594684094190598, -0.5385013222694397, -0.08007766306400299, -0.21106386184692383, 0.300825297832489, 0.1283913403749466, 0.39194685220718384, -0.2639315128326416, 0.1524956375360489, 0.09927870333194733, 0.19917942583560944, -0.10344792902469635, -0.3920048177242279, 0.6997699737548828, -0.499707967042923, -0.19525828957557678, -0.2512989938259125, 0.12538254261016846, -0.4811335504055023, -0.19253374636173248, -0.4114692211151123, -0.05235583707690239, -0.11504863947629929, -0.13749438524246216, 0.15629814565181732, 0.35579895973205566, -0.492864727973938, -0.0629006177186966, -1.775896430015564, 0.8021548986434937, -0.06961456686258316, -0.41975313425064087, -0.14882996678352356, -0.05927308276295662, 0.23814783990383148, -0.032581765204668045, 0.21536953747272491, 0.10802366584539413, -0.4704970121383667, -0.23640912771224976, 0.6518876552581787, -0.5783659815788269, -0.24095328152179718, 0.15261629223823547, -0.07104762643575668, -0.3107467293739319, 0.105398990213871, 0.6515894532203674, 0.061551544815301895, -0.3889613747596741, -0.8260582089424133, -0.15134753286838531, -0.1695999950170517, -0.2810085713863373, -0.2328624725341797, 0.16313745081424713, 0.06634992361068726, -0.6196330189704895, -0.1904613971710205, -0.26360422372817993, 0.014663634821772575, 0.4373972415924072, 0.5371975898742676, 0.5594897866249084, 0.472042977809906, -0.2289026528596878, 0.5142558813095093, -0.15229181945323944, -0.5604281425476074, 0.4634055495262146, -0.6162624955177307, -0.5148866176605225, 0.033370550721883774, -0.22734567523002625, 0.4101668894290924, 0.22767363488674164, -0.09194749593734741, 0.3358418941497803, 0.11004510521888733, -0.09320054948329926, -0.09143555909395218, 0.4220266044139862, -0.5151291489601135, -0.2750941812992096, 0.16047045588493347, -0.2172018140554428, -0.5239480137825012, -0.04616599902510643, -0.3138620853424072, -0.663936197757721, -0.5098800659179688, 0.6882179975509644, -0.8299633264541626, -0.08707010000944138, -0.27573123574256897, -0.3222253620624542, -0.19175921380519867, -0.20140981674194336, 0.02310141921043396, -0.2942183315753937, 0.059871356934309006, 0.1792435348033905, 0.1612076312303543, 1.500365138053894, -0.6023726463317871, 0.1539088487625122, -0.18962755799293518, -0.3140646815299988, 0.2871870696544647, -0.019991552457213402, -0.37709468603134155, 0.23492494225502014, 0.1666543036699295, 1.1088359355926514, -0.2873295843601227, 0.15647642314434052, 0.053407154977321625, -0.23896345496177673, -0.3238476514816284, -0.16254490613937378, -0.05467742681503296, -0.20265159010887146, -0.15642216801643372, -0.2531103193759918, -0.742057204246521, 0.09728222340345383, -0.13062897324562073, -0.5089919567108154, -0.21596194803714752, 0.38624686002731323, -0.05381469428539276, -0.07576171308755875, 0.03331749886274338, -0.07514709234237671, -0.5768863558769226, 0.07769221067428589, -0.2311846911907196, 0.27166226506233215, -0.0496039092540741, -0.42496177554130554, 0.49697545170783997, 0.1994773894548416, 0.3071102499961853, -0.20910859107971191, -0.467483252286911, 0.018273601308465004, 0.12374918907880783, -0.6062001585960388, 0.07399389892816544, 0.47092828154563904, -0.08960972726345062, 0.11778580397367477, -0.13393919169902802, -0.20390820503234863, 0.2514166831970215, -0.06795264035463333, 0.3615439832210541, -0.3244266211986542, 0.3643929064273834, -0.1518627554178238, -0.22288154065608978, 0.01702839508652687, -0.8211491703987122, -0.26176223158836365, -0.2966879606246948, -0.432246595621109, 0.43770304322242737, 0.8107722401618958, 0.33027955889701843, -0.05952853336930275, 0.5374091267585754, -0.2560138404369354, -0.06585291028022766, -0.5058464407920837, 0.029523175209760666, -0.40470364689826965, 1.1484215259552002, -0.23760688304901123, -0.14337271451950073, 1.190608024597168, 0.3060247302055359, 0.028483225032687187, 0.03692203387618065, -0.28622159361839294, 0.6565462946891785, -0.4022424817085266, 0.14111506938934326, 0.4165040850639343, 0.1406858265399933, -0.18785348534584045, 0.004734772723168135, 0.4237090051174164, 0.5852357149124146, -0.006215717177838087, 0.21892955899238586, -0.5067905783653259, 0.5024024248123169, -0.6327157020568848, -0.0562419593334198, 0.6238090395927429, -0.31012362241744995, 0.34623482823371887, 0.7245191931724548, -0.16880398988723755, 0.6564077138900757, 0.8744781613349915, -0.1482202410697937, 0.7248684763908386, 0.3208394944667816, 0.08445025980472565, 0.8448662161827087, -0.36307862401008606, 0.3829559087753296, -0.5127672553062439, -0.2590938210487366, -0.2960068881511688, -0.09627344459295273, 0.1872933804988861, 0.41199979186058044, 0.1375419944524765, 0.5528945922851562, -0.23725366592407227, -0.13321787118911743, 0.5391181707382202, -0.2639087736606598, 0.46769222617149353, 0.21034526824951172, -0.3454408049583435, -0.05665794387459755, 0.35934895277023315, -0.8772794008255005, -0.016930975019931793, 0.001235435949638486, 0.11715300381183624, -0.029218969866633415, -0.6827040314674377, 0.5968506336212158, 0.2779231667518616, -0.33922967314720154, 0.01847340352833271, 0.35966113209724426, -0.1285344660282135, 0.022732317447662354, -0.352516770362854, 0.2294006496667862, -0.06427378207445145, -0.052836645394563675, 0.03142599016427994, -0.20868341624736786, -0.16797888278961182, 1.211411476135254, 0.514933168888092, 0.8215480446815491, 0.07253144681453705, -0.4763941168785095, 0.06395328789949417, -0.09019085764884949, -0.4671328365802765, 0.09452933073043823, 0.7434560656547546, -0.9674540162086487, -0.8704355359077454, 0.08596299588680267, -0.03317713364958763, 0.6244463324546814, 0.25159505009651184, -0.5612322092056274, -0.10747591406106949, -0.1783786118030548, -0.8282495737075806, -0.607578456401825, -0.293188214302063, -0.22914165258407593, 0.11308711767196655, -0.3984413146972656, 0.20987777411937714, -0.13036265969276428, 0.9892580509185791, -0.1427372246980667, 0.5331201553344727, 0.7607123851776123, -0.4775833487510681, 0.021304985508322716, 0.04888109490275383, -0.634360134601593, -0.00451569352298975, 0.042773790657520294, -0.39599335193634033, -0.22503821551799774, 0.23574282228946686, -5.63503360748291, 0.48089364171028137, -0.09740811586380005, 0.002092766808345914, 0.1453082114458084, -0.10704249888658524, 0.9036716818809509, 0.21414390206336975, 0.3880603015422821, 0.5028991103172302, -0.008405094034969807, 0.5867789387702942, -0.3816349506378174, 0.1705024093389511, -0.06635985523462296, -0.20926153659820557, 0.009701734408736229, -0.19494444131851196, 0.3441610038280487, 0.09776610881090164, 0.34752267599105835, -0.1562134027481079, 0.03476491943001747, 0.6071421504020691, 0.42567476630210876, -0.529063880443573, -0.6776542067527771, 0.398214191198349, -0.30493777990341187, -0.4310286343097687, -0.04801788181066513, -0.4422621428966522, -0.051338545978069305, -0.01994010992348194, 0.7121822237968445, -0.004231189377605915, 0.21477098762989044, 0.21582727134227753, 0.4064793288707733, -0.762035608291626, 0.725894570350647, 0.7344674468040466, -0.21954478323459625, -0.10211751610040665, 0.24951426684856415, -0.6272794604301453, -0.3277212977409363, -0.08161236345767975, -0.3554462194442749, 0.7760293483734131, 0.019936731085181236, -0.21397711336612701, 0.2744627296924591, 0.7494692802429199, 0.8767864108085632, -0.12206344306468964, -0.020237741991877556, -0.16111724078655243, -0.417650043964386, 0.6806100010871887, -0.13654708862304688, 0.0824265107512474, -0.790099561214447, -0.2593742311000824, -0.18666912615299225, 0.15023252367973328, -0.5489208102226257, -0.5671254396438599, 0.07381369173526764, -0.41414761543273926, -0.5144988298416138, 0.4153735935688019, 0.15689823031425476, -0.586005687713623, 0.8550109267234802, -0.25513094663619995, 0.31167101860046387, 0.07236140966415405, -0.08044692873954773, 0.48225873708724976, -0.7841320633888245, -0.3781925439834595, -0.11202054470777512, 0.33536890149116516, -0.1482023000717163, 0.19067151844501495, 0.2634814977645874, -0.17782868444919586, -0.3083387017250061, 0.16037504374980927, 0.5528613924980164, -0.5333353281021118, 0.19219478964805603, 0.543422281742096, -0.47840213775634766, -0.20830102264881134, -0.04128755256533623, 0.4850957989692688, 0.8566370606422424, 0.6419246792793274, 1.288346529006958, 0.18601980805397034, -0.5736865401268005, -0.4918992817401886, 0.32965216040611267, -0.09344074130058289, 0.09043676406145096, -0.13993488252162933, 1.0844306945800781, -0.5410044193267822, 0.171275794506073, 0.14736014604568481, -0.29252657294273376, -0.5379087328910828, 0.7133345007896423, -0.24190670251846313, -0.15666548907756805, 0.12527494132518768, 0.3288044333457947, -0.4116222858428955, 0.38957422971725464, 0.3758488893508911, -0.5857663750648499, 0.7570595145225525, -0.12758590281009674, 0.11829948425292969, -0.20549190044403076, 0.5698021650314331, -1.1144837141036987, -0.12213130295276642, 0.42022737860679626, 0.11658140271902084, 0.02512550726532936, -0.018777847290039062, 0.40383198857307434, -0.5915800929069519, -0.04004581645131111, 0.20443683862686157, 0.16130253672599792, -0.42395344376564026, 0.36843886971473694, -0.18420511484146118, -0.1296652853488922, -0.6269915699958801, -0.16004234552383423, 0.08952014148235321, 0.013559549115598202, 0.1417897492647171, -0.7400855422019958, -0.20834998786449432, 0.22931283712387085, -0.014616234228014946, 0.27079784870147705, 0.39776697754859924, -0.2570275068283081, 0.17363475263118744, 0.7917203903198242, 0.36860859394073486, 0.6719511151313782, -0.5025043487548828, 0.49091657996177673, 0.44572919607162476, -0.6937880516052246, -0.07001853734254837, 0.10396596789360046, -0.6498144268989563, -0.25743526220321655, -0.6575203537940979, 0.33152928948402405, 0.37244415283203125, -0.3365933895111084, 0.21108078956604004, -0.33623936772346497, -0.0011902354890480638, -0.1676524430513382, -0.3268042802810669, -0.4281071126461029, 0.03003641963005066, -0.16169121861457825, -0.07941985875368118, 0.46452826261520386, -0.521003246307373, -0.5132004618644714, 0.03510855510830879, 0.06611964851617813, 0.41903454065322876, -0.07528790831565857, 0.07047660648822784, -0.10061471164226532, -0.7713823914527893, -0.3809410333633423, -0.23573477566242218, -0.0007836675504222512, -0.6123778820037842, 0.3503941297531128, -0.014456710778176785, 0.29213255643844604, 0.3652119040489197, -0.31726542115211487, -0.7016313672065735, -0.004763287957757711, 0.36527711153030396, -0.959502637386322, 0.16776520013809204, 0.1182834729552269, 0.20486974716186523, 0.19763940572738647, 0.21437174081802368, 0.2804275453090668, 0.10757053643465042, -0.16698041558265686, -0.6684592962265015, 0.20803701877593994, -0.42904922366142273, 0.04897923395037651, 0.21941865980625153, 0.44924819469451904, -0.35177847743034363, -0.2101360410451889, -0.16026604175567627, 0.33039307594299316, -0.43892061710357666, 0.14340274035930634, 0.30707478523254395, -0.5052593350410461, -0.23549742996692657, 0.25189775228500366, -0.5186270475387573, 0.5028851628303528, -0.18585455417633057, -0.3516102135181427, -0.07360747456550598, 0.1526918113231659, 0.6773309111595154, -0.5149646401405334, -0.48673519492149353, -0.7409327626228333, 0.44253161549568176, -0.2895738482475281, 0.4060308337211609, 0.7852365970611572, 0.5298916101455688, -0.4303901791572571, 0.22313474118709564, 0.08395223319530487, 0.4926432967185974, -0.1322159320116043, -0.2605265974998474, -0.4202142059803009, 0.12827196717262268, 0.36736243963241577, -0.016655655577778816, -0.08688420057296753, 0.42982086539268494, 0.8977972269058228, -0.41084161400794983, 0.43638062477111816, -0.010071184486150742, -0.5155242085456848, 0.44797220826148987, -0.4091506898403168, -0.22645610570907593, 0.03064572997391224, 0.2643375098705292, -0.06043199077248573, 0.13996240496635437, -0.3115890622138977, -0.817998468875885, 0.23145835101604462, -0.32214081287384033, -0.2630181312561035, 0.16315793991088867, 0.6691027879714966, -0.2942221760749817, -0.18638816475868225, 0.6071076989173889, -0.1849549412727356, 0.543415904045105, -0.18002118170261383, -0.18666313588619232, -0.36807411909103394, -0.6539037823677063, 0.21312940120697021, -0.5922598838806152, 0.12257308512926102, -0.6125732660293579, 0.013658614829182625, -0.3314756155014038, -0.4174233078956604, -0.31250259280204773, -0.09046701341867447, 0.1560056507587433, -0.9126769304275513, -0.27984723448753357, -0.21323999762535095, -0.08211745321750641, -0.3142508268356323, 0.3566094636917114, 0.29275840520858765, 0.18422512710094452, -0.7662979364395142, 0.33892375230789185, 0.5142549276351929, -0.2530432343482971, -0.007792091928422451, 0.21165940165519714, 0.3795599639415741, -0.290529727935791, -0.4748019278049469, -0.27567747235298157, -0.1442096084356308, -0.36919882893562317, 0.4314053952693939, 0.022698746994137764, -0.11888687312602997, 0.3485301733016968, 0.184552863240242, -0.2677527964115143, 0.22681158781051636, 0.3612806499004364, 0.0033547054044902325, 0.08278368413448334, 0.1760341376066208, 0.20629620552062988, -0.7098256945610046, 0.32009175419807434, -0.020298492163419724, 0.20332175493240356, 0.0188746377825737, 0.4201444387435913, 0.3744097054004669, 0.2806706130504608, -0.1907956451177597, 0.40263938903808594, 0.6672860383987427, 0.00041671571671031415, 0.28426530957221985, -0.5359437465667725, -0.10083460807800293, 0.13987861573696136, 0.4089723527431488, 0.7653738260269165, -0.625175952911377, -0.025319037958979607, 0.26830458641052246, 0.5714362859725952, 0.08960552513599396, 0.3871936500072479, -0.4111310541629791, 0.533240795135498, -0.040833547711372375, -0.07562156021595001, -0.5638828873634338, 0.19372054934501648, -0.9842656850814819, 0.429612398147583, 0.8580842614173889, -0.48525500297546387, -0.5073288083076477, 0.2795250415802002, -0.25923827290534973, 0.21152736246585846, 0.43434277176856995, 0.14279671013355255, -0.3970258831977844, -0.24383622407913208, 0.3699605464935303, -0.2984878122806549, 0.3438432216644287, -0.31330546736717224, -0.2387765347957611, 0.25700557231903076, -0.6768321990966797, 0.0143217071890831, -0.002349358983337879, -0.36124348640441895, 0.443352609872818, -0.3531995415687561, 0.2960667312145233, 0.6177949905395508, -0.2595708668231964, 0.4924580156803131, -0.02796889841556549, -0.455178439617157, -0.34266629815101624, -0.21310174465179443, -0.2884471118450165, -0.017764778807759285, 0.23092657327651978, 0.014943118207156658, -0.4039883017539978, -0.5989269018173218, 0.23841390013694763, 0.39466723799705505, 0.1274503767490387, -0.22921492159366608, -0.1825307458639145, 0.4653908908367157, 0.49034130573272705, 0.6160995960235596, 0.2500722408294678, 0.6083987355232239, -0.23499351739883423, 0.3759593069553375, -0.2544825077056885, 0.3583827316761017, -0.6028582453727722, -0.36428555846214294, -0.21334156394004822, -0.13441066443920135, 1.126584529876709, 0.2955649495124817, -0.2322961539030075, -0.16186386346817017, 0.46011731028556824, 0.18639704585075378, 0.7804624438285828, -0.49562132358551025, -0.016029370948672295, -0.5817374587059021, 0.07055258750915527, -0.14078010618686676, 0.19719168543815613, -0.3351355791091919, 0.0008493058267049491, 0.2910829782485962, 0.374113529920578, 0.22612924873828888, -0.5969117283821106, 0.08926109969615936, -0.4348028004169464, -0.20536832511425018, -1.006740689277649, 0.44845396280288696, -0.41815340518951416, 0.43264302611351013, -0.4589739441871643, -0.08660578727722168, 0.447735071182251, 0.01522145513445139, 0.06675955653190613, 0.1995023936033249, 0.14913596212863922, -0.051000915467739105, 0.17014080286026, 0.36665719747543335, -0.3352172374725342, -0.96839839220047, -0.545130729675293, 0.45944857597351074, 0.19471853971481323, -0.4561946988105774, -0.045539818704128265, 0.2714553773403168, -0.36507052183151245, 0.1279262751340866, 0.31930530071258545, -0.4546852707862854, -0.15026076138019562, 0.28935450315475464 ]
In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 genes. To gain insight into the structure and function of bivalent domains, we mapped key histone modifications and subunits of Polycomb-repressive complexes 1 and 2 (PRC1 and PRC2) genomewide in human and mouse ES cells by chromatin immunoprecipitation, followed by ultra high-throughput sequencing. We find that bivalent domains can be segregated into two classes -- the first occupied by both PRC2 and PRC1 (PRC1-positive) and the second specifically bound by PRC2 (PRC2-only). PRC1-positive bivalent domains appear functionally distinct as they more efficiently retain lysine 27 tri-methylation upon differentiation, show stringent conservation of chromatin state, and associate with an overwhelming number of developmental regulator gene promoters. We also used computational genomics to search for sequence determinants of Polycomb binding. This analysis revealed that the genomewide locations of PRC2 and PRC1 can be largely predicted from the locations, sizes, and underlying motif contents of CpG islands. We propose that large CpG islands depleted of activating motifs confer epigenetic memory by recruiting the full repertoire of Polycomb complexes in pluripotent cells.
[ 0.021064594388008118, 0.001891518011689186, -0.02599378116428852, 0.01442145649343729, 0.011612447910010815, -0.0033800466917455196, 0.013354608789086342, 0.018577832728624344, -0.016595590859651566, -0.002719272393733263, -0.006285134237259626, 0.006443382706493139, -0.016884440556168556, 0.009681406430900097, 0.03218291327357292, 0.012428946793079376, -0.022483691573143005, 0.005840673577040434, 0.015030641108751297, 0.02911074087023735, 0.024049745872616768, 0.013211624696850777, 0.011241552419960499, -0.022151613608002663, -0.003713054582476616, 0.005898450966924429, 0.02951078489422798, 0.0026570053305476904, -0.009643234312534332, -0.015950508415699005, 0.039992086589336395, -0.027170687913894653, 0.02068261057138443, -0.006720581091940403, -0.010071462020277977, -0.005696196109056473, -0.006110737100243568, 0.027789955958724022, 0.05077895149588585, -0.0057042445987463, -0.016962215304374695, -0.018335124477744102, 0.005880646873265505, -0.00920444168150425, -0.00901058316230774, -0.012295964173972607, -0.009786698967218399, -0.004455153830349445, 0.03294594585895538, 0.0033588220831006765, -0.012122593820095062, -0.010138873010873795, -0.017680395394563675, 0.009434483014047146, -0.007428377866744995, 0.015657315030694008, 0.022252295166254044, -0.030483536422252655, -0.02487221546471119, 0.027072537690401077, 0.03203463926911354, 0.03109622187912464, 0.012260835617780685, -0.00022550439462065697, 0.004800009075552225, -0.06603726744651794, -0.010851142928004265, 0.011730259284377098, -0.004009237978607416, -0.02798175811767578, -0.017138022929430008, 0.013519259169697762, -0.01814453676342964, -0.022164665162563324, -0.027086317539215088, -0.02476654015481472, -0.028119102120399475, -0.000610299059189856, 0.04351236671209335, 0.004207069519907236, 0.02806573361158371, 0.0022707025054842234, 0.010297013446688652, 0.011912798509001732, -0.005103748757392168, 0.013515710830688477, -0.028581317514181137, -0.003031307365745306, 0.030810389667749405, -0.05851811170578003, -0.017237843945622444, 0.003982691094279289, 0.007312252186238766, -0.0034213538747280836, -0.0035414753947407007, 0.0055528078228235245, -0.01409419160336256, -0.0020659270230680704, 0.015700973570346832, -0.018578985705971718, -0.021610157564282417, 0.028432592749595642, 0.012890633195638657, -0.004705667495727539, -0.00567754078656435, 0.010354973375797272, -0.013117795810103416, 0.01588895544409752, 0.02044595219194889, 0.009846774861216545, -0.0067354110069572926, -0.016095560044050217, 0.004879872780293226, 0.01709226332604885, 0.003605918725952506, -0.025397537276148796, -0.028895340859889984, 0.04157206416130066, 0.00514480285346508, 0.0248170904815197, 0.00816725380718708, -0.012259239330887794, 0.006741360295563936, -0.012719225138425827, 0.008621567860245705, -0.040095649659633636, -0.04238129034638405, 0.018862901255488396, 0.00746758421882987, 0.005585990380495787, -0.00981011800467968, -0.004885571543127298, 0.011009887792170048, -0.011259484104812145, -0.02529359981417656, -0.0033466999884694815, -0.0028992900624871254, 0.0048825982958078384, -0.009839492850005627, -0.0023476427886635065, 0.02133815363049507, 0.009692749008536339, 0.003752005286514759, 0.010022755712270737, -0.004008951596915722, 0.005573522765189409, -0.01893835887312889, -0.021707436069846153, 0.019798260182142258, -0.028663523495197296, 0.017084432765841484, -0.031650789082050323, 0.0019814621191471815, -0.01840316317975521, 0.01447738241404295, 0.02200537547469139, -0.006935402285307646, 0.014267808757722378, 0.0021966760978102684, 0.020940538495779037, -0.002154541201889515, -0.006983672268688679, 0.006834758911281824, 0.012367092072963715, 0.0016290796920657158, 0.01631515473127365, 0.009040468372404575, 0.00491471029818058, 0.008479938842356205, 0.006414834409952164, -0.011902403086423874, 0.016181552782654762, 0.017441468313336372, 0.017793282866477966, 0.0013665789738297462, -0.0002857398649211973, -0.0001735765254124999, 0.007586207706481218, -0.02757924422621727, 0.0664939433336258, -0.014799706637859344, 0.018554922193288803, -0.008493875153362751, -0.012344900518655777, 0.008803490549325943, 0.007489978801459074, -0.024630483239889145, -0.0002449851017445326, -0.019930236041545868, -0.02968505769968033, 0.03278762847185135, 0.027374792844057083, -0.004418634809553623, -0.006248175632208586, -0.025029931217432022, 0.002636678982526064, -0.015281705185770988, 0.0063569750636816025, -0.002495469991117716, -0.002656275872141123, 0.019405540078878403, -0.005776373203843832, 0.029915956780314445, 0.012722177430987358, -0.004307161085307598, 0.013911085203289986, 0.01753762736916542, 0.010648813098669052, -0.012940991669893265, 0.02349567413330078, 0.03018965758383274, -0.030109286308288574, -0.0062131378799676895, -0.010602736845612526, 0.0009856424294412136, 0.004676349461078644, -0.0022845007479190826, 0.013180159032344818, -0.008975766599178314, -0.019113827496767044, 0.005133370868861675, 0.010045148432254791, 0.003494055476039648, -0.004714434966444969, 0.02431538887321949, -0.020938578993082047, -0.00328396400436759, 0.0138540742918849, -0.03177255392074585, 0.025052649900317192, -0.007662628777325153, -0.035337239503860474, -0.01773235574364662, 0.004838872700929642, 0.015309617854654789, -0.005830918438732624, 0.014715625904500484, 0.0030427908059209585, 0.010248089209198952, -0.009592318907380104, -0.017333805561065674, -0.006776796653866768, 0.02116384170949459, -0.02919401228427887, 0.003780171275138855, -0.015307560563087463, 0.01363437995314598, 0.011623194441199303, 0.027477573603391647, -0.028435392305254936, 0.008455460891127586, 0.025315534323453903, -0.011719021014869213, 0.0010611279867589474, -0.0255091842263937, 0.010710282251238823, -0.013857868500053883, 0.012972232885658741, 0.025817448273301125, 0.017213795334100723, -0.0013540179934352636, 0.008644148707389832, -0.006025111302733421, 0.0070952302776277065, -0.005373230669647455, -0.007559046149253845, -0.005788418930023909, 0.013397078961133957, 0.007345438934862614, -0.02268076315522194, 0.012973281554877758, -0.006077891681343317, 0.010587872937321663, -0.08070917427539825, -0.010224278084933758, 0.0026278686709702015, -0.019540129229426384, 0.00866791047155857, 0.0005862126126885414, -0.008102376013994217, 0.010859072208404541, -0.007312656380236149, -0.008480899967253208, 0.029185624793171883, 0.020391710102558136, -0.014904113486409187, -0.036957599222660065, -0.021559618413448334, -0.010817121714353561, 0.014480296522378922, -0.021505940705537796, -0.014704810455441475, -0.026651568710803986, -0.03017384372651577, 0.002807079814374447, -0.036920905113220215, 0.03812573477625847, -0.012641584500670433, 0.015102108009159565, 0.013608807697892189, -0.0136184673756361, -0.02001630701124668, -0.0008467718726024032, -0.03239857777953148, -0.011602837592363358, 0.02776995673775673, 0.0032524876296520233, 0.007925016805529594, -0.0005695205181837082, -0.0018973731203004718, -0.015665821731090546, -0.025624161586165428, 0.034482426941394806, -0.015516066923737526, 0.011099245399236679, -0.002731229644268751, -0.002105327323079109, 0.0008481589611619711, -0.012989712879061699, 0.0030077681876719, 0.041767463088035583, 0.031707219779491425, -0.01522067654877901, 0.01873321458697319, 0.006409798748791218, 0.012353598140180111, 0.023837968707084656, -0.014785457402467728, 0.0032174009829759598, -0.02123306877911091, 0.02605174295604229, -0.011575442738831043, -0.014201060868799686, 0.008733058348298073, -0.016789494082331657, -0.00876198522746563, 0.01108267530798912, -0.01368353608995676, 0.03487147390842438, 0.0026629369240254164, 0.01348923984915018, -0.022841831669211388, 0.021653030067682266, 0.012088876217603683, 0.0015296291094273329, -0.016628582030534744, -0.010013674385845661, -0.027294857427477837, -0.007104408927261829, -0.014776583760976791, -0.0018478234997019172, 0.0008243739139288664, -0.025469347834587097, -0.004795151297003031, -0.010802175849676132, -0.02487613633275032, -0.04168084263801575, -0.017750408500432968, -0.02884334698319435, 0.007452759426087141, 0.00294775003567338, 0.009241393767297268, -0.012269474565982819, -0.01423337310552597, -0.01037695724517107, -0.008830882608890533, 0.011938384734094143, -0.012590114027261734, -0.031914688646793365, 0.012587465345859528, 0.01839132234454155, 0.02309723198413849, 0.010268354788422585, -0.010827283374965191, -0.004454672336578369, -0.012972904369235039, -0.009398436173796654, -0.04140715301036835, 0.014593868516385555, -0.022302355617284775, -0.02386939525604248, 0.023606717586517334, 0.0015548723749816418, 0.002954671159386635, 0.004261511377990246, -0.012618409469723701, 0.011505255475640297, 0.016078274697065353, 0.028634190559387207, 0.007041951175779104, 0.006392346695065498, 0.07097990065813065, 0.022118715569376945, -0.0030603138729929924, -0.019091889262199402, 0.02248171716928482, -0.02789268270134926, -0.003822317346930504, 0.009611876681447029, -0.018006572499871254, -0.00920335203409195, 0.013859990052878857, -0.006015042774379253, 0.010151306167244911, -0.02458273619413376, -0.016552411019802094, -0.010569814592599869, -0.023069148883223534, -0.0012307744473218918, -0.009548390284180641, 0.029964741319417953, -0.00014740345068275928, -0.013178158551454544, -0.002822748851031065, 0.009164897724986076, 0.014051388949155807, -0.005298375152051449, -0.0019597497303038836, -0.011755812913179398, -0.023175949230790138, 0.01802792027592659, 0.0013924171216785908, -0.0182667076587677, -0.010905792936682701, -0.0027936454862356186, 0.05186954885721207, 0.020736660808324814, 0.009995019994676113, 0.008622847497463226, -0.017295382916927338, 0.000735905603505671, 0.019567042589187622, -0.012905485928058624, 0.027801798656582832, 0.01301768608391285, 0.018482547253370285, 0.008261733688414097, 0.03666336089372635, -0.0046829041093587875, 0.001527559943497181, -0.030037062242627144, -0.011903367936611176, 0.004053393378853798, 0.01830242946743965, 0.02504926361143589, -0.0030643169302493334, -0.005975812673568726, 0.005674622021615505, -0.0034259925596415997, 0.009639354422688484, 0.0017763213254511356, -0.020473435521125793, -0.013273143209517002, -0.006418951787054539, -0.0023885206319391727, 0.0125714261084795, -0.026497822254896164, -0.007757427170872688, 0.004510820377618074, -0.006732737645506859, 0.0027967276982963085, 0.014396819286048412, -0.005398251581937075, -0.0022277720272541046, -0.004051774274557829, -0.011631311848759651, 0.007039227522909641, -0.006168241612613201, -0.0013903577346354723, 0.04397420585155487, -0.004202698823064566, -0.007880776189267635, 0.020330216735601425, 0.013247648254036903, -0.00914871133863926, 0.011987773701548576, -0.006331273354589939, -0.026225507259368896, -0.07375804334878922, -0.025088263675570488, 0.003961827605962753, -0.007019123062491417, 0.007716035470366478, 0.012006813660264015, -0.011537453159689903, 0.003888969775289297, -0.0059799738228321075, -0.009605905041098595, -0.00482601672410965, 0.01343043427914381, -0.006690865382552147, 0.011373571120202541, 0.011736122891306877, 0.005621472839266062, -0.01996742933988571, 0.006820040754973888, -0.009360027499496937, 0.003164320718497038, -0.01762065663933754, 0.014087392017245293, -0.00854155607521534, -0.0023811908904463053, -0.012549139559268951, -0.08000271767377853, 0.003047814592719078, -0.01739141158759594, 0.004896531812846661, -0.004000096581876278, 0.012276154942810535, 0.017052091658115387, -0.01924118772149086, -0.021022804081439972, -0.018311653286218643, 0.0016483957879245281, 0.030637871474027634, -0.018345506861805916, -0.023390628397464752, 0.017223767936229706, -0.002917352132499218, 0.01661454699933529, 0.017767492681741714, -0.011191538535058498, 0.01634693518280983, -0.014261027798056602, 0.012574818916618824, -0.01439904049038887, 0.01019266713410616, -0.008554764091968536, 0.010722881183028221, -0.0044290050864219666, 0.016719983890652657, 0.010210205800831318, -0.0028901267796754837, -0.010637300089001656, 0.004567309282720089, -0.012986418791115284, -0.025947323068976402, 0.004229639191180468, -0.034052833914756775, 0.0040775989182293415, 0.005804422311484814, -0.01326022855937481, 0.0003274516202509403, -0.005754802841693163, 0.006068372633308172, -0.00789891742169857, 0.011744164861738682, 0.01021050289273262, -0.019860245287418365, 0.007088206708431244, -0.005354956723749638, -0.003991660661995411, 0.02186543308198452, 0.0060247029177844524, -0.034230511635541916, 0.013076215982437134, 0.017331471666693687, 0.005677852313965559, 0.01502098236232996, -0.005115400534123182, 0.02893787994980812, 0.023244120180606842, 0.001948601333424449, -0.01317826472222805, -0.009006140753626823, 0.009631659835577011, 0.07152527570724487, -0.02371128462255001, 0.00825927872210741, -0.013497954234480858, 0.004725677892565727, 0.006756455637514591, 0.0005210926756262779, -0.04088698700070381, -0.007677484303712845, -0.016694415360689163, 0.00442482577636838, -0.005587510298937559, 0.002108178101480007, 0.01855965331196785, -0.02546294406056404, 0.012744908221065998, -0.00603084173053503, 0.042387112975120544, -0.01744028925895691, 0.05488632619380951, -0.018738433718681335, -0.025456687435507774, -0.013144109398126602, 0.026783572509884834, -0.0016242396086454391, -0.005435806233435869, -0.015222554095089436, 0.010090842843055725, 0.013814443722367287, -0.000982373021543026, -0.010392998345196247, -0.007089551538228989, 0.0046484386548399925, 0.0011210663942620158, 0.021986283361911774, 0.010790602304041386, -0.026241838932037354, 0.014554103836417198, 0.0053222388960421085, 0.005283769220113754, -0.02552463486790657, 0.005831276997923851, -0.004438462667167187, -0.002456038724631071, -0.01097352709621191, -0.01686835289001465, 0.010054468177258968, -0.01588522642850876, 0.004328043665736914, -0.011687332764267921, 0.01447182148694992, 0.0022477712482213974, 0.031387753784656525, -0.0177400354295969, 0.015252419747412205, 0.02665616013109684, -0.00450320728123188, 0.022480245679616928, -0.03394308686256409, 0.012794826179742813, 0.015156658366322517, -0.012134062126278877, -0.004753966815769672, -0.012633604928851128, 0.004503668751567602, 0.0142325134947896, 0.01575693115592003, -0.012270296923816204, -0.0007970973383635283, 0.021032625809311867, -0.005038753617554903, -0.0071495939046144485, 0.009894736111164093, 0.01509959064424038, 0.016660014167428017, 0.02299881912767887, 0.024839598685503006, -0.013846579939126968, 0.020535824820399284, 0.0005703936330974102, -0.014622674323618412, 0.026601741090416908, 0.000694493530318141, -0.006110985763370991, 0.004352580290287733, 0.011617463082075119, 0.009260270744562149, 0.01067720539867878, 0.0018517496064305305, 0.01507613155990839, 0.029915185645222664, 0.021993231028318405, 0.007496049627661705, -0.006266095209866762, 0.005100809037685394, 0.034680381417274475, 0.023397058248519897, 0.001956622116267681, -0.026213034987449646, -0.013707153499126434, 0.02943967469036579, 0.019106276333332062, 0.0043404982425272465, -0.004336437210440636, -0.0038373363204300404, -0.010763199999928474, 0.009107790887355804, 0.016871817409992218, -0.0077423714101314545, 0.01740770787000656, 0.010989121161401272, -0.028198271989822388, 0.0068095093593001366, 0.005596884526312351, 0.00010741641744971275, 0.015429215505719185, -0.015467084012925625, 0.003388263052329421, -0.03330674767494202, -0.019779518246650696, 0.02755366452038288, 0.0212874598801136, -0.03035590797662735, -0.02568461000919342, 0.03183645009994507, -0.010051264427602291, -0.012889398261904716, 0.021412387490272522, 0.012667296454310417, -0.01533929817378521, 0.0243531446903944, 0.0030071993824094534, 0.004841369576752186, 0.029895935207605362, -0.004966537933796644, 0.008313892409205437, -0.039120469242334366, 0.02642904967069626, -0.0012466914486140013, -0.01504787988960743, 0.003801770508289337, -0.029022764414548874, -0.004244185984134674, -0.008058025501668453, 0.0093975979834795, -0.017174726352095604, 0.012818340212106705, -0.01820099540054798, 0.001011586282402277, -0.003992137964814901, 0.010829204693436623, 0.008349286392331123, -0.014901495538651943, -0.007183324545621872, -0.00001051207073032856, 0.027786100283265114, -0.0003509516827762127, -0.025297697633504868, -0.03516383469104767, -0.018842367455363274, 0.010698169469833374, 0.008309463039040565, 0.008528202772140503, -0.010464197024703026, -0.004808501806110144, -0.008644829504191875, 0.007183433044701815, 0.00523720309138298, 0.01473684050142765, 0.0009591607376933098, 0.03164715692400932, 0.017095930874347687, -0.006023084744811058, 0.037390269339084625, -0.018624508753418922, 0.0005224708002060652, -0.00824776105582714, 0.011028078384697437, 0.009137989953160286, -0.01334972120821476, 0.021498529240489006, -0.019058924168348312, 0.008532785810530186, -0.013853136450052261, 0.0022098245099186897, -0.031042035669088364, -0.005786498077213764, -0.011219417676329613, 0.008923618122935295, 0.0030975984409451485, -0.003980293869972229, -0.0023351761046797037, -0.01361067034304142, 0.008432388305664062, -0.011871226131916046, -0.010931346565485, 0.0007764722686260939, -0.02173127979040146, 0.011783755384385586, 0.0009394908556714654, 0.010707633569836617, -0.018335800617933273 ]
[ 0.05964748188853264, 0.05730860307812691, 0.39610475301742554, 0.4670703709125519, 0.6586226224899292, 0.32151731848716736, -0.23573580384254456, 0.16917946934700012, 0.18022499978542328, -0.4463558495044708, -0.11665825545787811, 0.022373642772436142, 0.19196100533008575, 0.3163529634475708, -0.06741325557231903, 0.04651530086994171, 0.10357195883989334, 0.48475825786590576, 0.049781039357185364, -0.7478788495063782, -0.1484212726354599, -0.572960376739502, 0.7262060642242432, -0.08719491213560104, 0.2184741497039795, 0.16450490057468414, -0.20121106505393982, -0.6423444151878357, 0.47813335061073303, 0.07005312293767929, -0.06932195276021957, 0.6377964615821838, 0.006778189446777105, 0.13420791923999786, -0.5709087252616882, -0.35616180300712585, -0.8314608931541443, 0.15327931940555573, -0.04155109077692032, -0.35745006799697876, -0.23019415140151978, -0.2216281145811081, -0.18429958820343018, 0.45067593455314636, -0.10569221526384354, -0.1690542846918106, -1.1611624956130981, 0.8767841458320618, -0.05414486676454544, 0.3625657856464386, -0.42965465784072876, -0.1084214374423027, 0.28164413571357727, -0.2344932109117508, 0.46348536014556885, -0.26729732751846313, -0.4517335295677185, -0.10772649943828583, 0.6085619926452637, -0.6766573786735535, 0.19412612915039062, 0.35002613067626953, 0.029844218865036964, 0.28962236642837524, 0.26079797744750977, 0.2182835340499878, 0.08326811343431473, -0.5141300559043884, -0.9221837520599365, -0.17461811006069183, 0.24566203355789185, -0.09014347940683365, -0.11844547092914581, 0.4232126772403717, -0.013974441215395927, -0.064219169318676, -0.4627586603164673, 0.2752395570278168, 0.3824675381183624, 0.005437467247247696, 0.20922309160232544, -0.04596824198961258, 0.2957614064216614, 0.07220953702926636, 0.6045028567314148, 0.3021129369735718, -0.5249067544937134, 0.26735877990722656, -0.7408561110496521, -0.15610748529434204, -0.2031155526638031, -0.12763792276382446, 0.2560778558254242, 0.3879816234111786, 0.24083209037780762, 0.4343402683734894, -0.062019698321819305, -0.14286991953849792, -0.05882813036441803, 0.29558390378952026, -0.35815179347991943, 0.34618112444877625, 0.0991031751036644, -0.5479428172111511, -0.9874418377876282, -0.15244421362876892, -0.06198858469724655, -0.42832592129707336, -0.2680589258670807, -0.01035239640623331, -0.4646516740322113, -0.164474755525589, -0.4755101501941681, 0.28533434867858887, -0.1909288465976715, 0.37702426314353943, 0.15127210319042206, -0.081086166203022, -0.015295859426259995, -0.20384962856769562, -0.7754561305046082, 0.940754234790802, -0.22092440724372864, 0.12103767693042755, 0.14721018075942993, 0.33826959133148193, 0.024331681430339813, -0.13177451491355896, 0.16339200735092163, 0.24610337615013123, -0.024617424234747887, 0.7343735694885254, 0.109498530626297, -0.2210521250963211, -0.2547459006309509, 0.11174813657999039, 0.5705694556236267, 0.0462983101606369, 0.41005340218544006, 0.46909773349761963, -0.5088943839073181, -0.714815616607666, -0.11146651208400726, 0.054022904485464096, 0.09735191613435745, -0.5708490014076233, -0.6658657193183899, -0.20805469155311584, -0.35352182388305664, -0.09184128791093826, -0.1730949580669403, -0.6674674153327942, -0.6156058311462402, -0.5461771488189697, 0.3403623700141907, 0.3318937122821808, -0.34089964628219604, 0.216955304145813, 0.13505029678344727, -0.058954425156116486, 0.3979400396347046, -0.1176963821053505, -0.19155192375183105, 0.10181485861539841, 0.46054697036743164, -0.09392998367547989, 0.5862094759941101, 0.08730747550725937, -0.5957214832305908, 0.491166353225708, -0.11613722890615463, -0.3212009370326996, 0.16544748842716217, -0.3161489963531494, -0.6886228919029236, -0.2782056927680969, 0.24661514163017273, -0.22405245900154114, 0.1937338262796402, -0.15545396506786346, -0.6034147143363953, -0.0473485141992569, 0.28377565741539, -0.314802885055542, -0.1388876736164093, 0.23470312356948853, 0.27552130818367004, 0.18879294395446777, 0.008661886677145958, 0.06947542726993561, -0.2918223440647125, -0.5763741731643677, 0.9285627603530884, -0.5305920839309692, 1.2465524673461914, -0.2847434878349304, 0.2953338921070099, 0.9896718263626099, -0.10718989372253418, 0.10162702947854996, -0.5590396523475647, -0.14581988751888275, 0.9322333931922913, -0.17119565606117249, -0.5603677034378052, 0.07147173583507538, -0.1454543173313141, -0.9431810975074768, 0.23802588880062103, -0.4568479657173157, -0.1322125792503357, -0.11055546998977661, -0.04810906574130058, 0.11577878892421722, 0.3080049753189087, -0.6192389130592346, 0.1109197810292244, -0.06490437686443329, -0.4330037832260132, -0.24226617813110352, 0.6004056334495544, -0.8014233112335205, 0.5639904141426086, 0.4063437879085541, -0.36970382928848267, 0.21903002262115479, 0.1836465448141098, -0.0018947422504425049, 0.46730050444602966, -0.3568515181541443, 0.26791393756866455, -0.9118492007255554, 0.3882984220981598, -0.45688581466674805, -0.20307007431983948, 0.24815808236598969, 0.2886539399623871, -0.05021024867892265, 0.07143445312976837, -0.22443512082099915, -0.07238420844078064, 0.7166552543640137, -0.8173601031303406, -0.33396369218826294, 0.352893203496933, -0.04276837408542633, -0.09532472491264343, 0.3946142792701721, -0.7351464033126831, -0.18745003640651703, -0.19350914657115936, -0.060094088315963745, 0.08705183118581772, -0.8387280702590942, 0.14529073238372803, 0.16283613443374634, 0.2084663212299347, -0.13458774983882904, -0.27540838718414307, -0.1034703254699707, -0.004339816048741341, -0.27772945165634155, 0.22983773052692413, 0.5182629823684692, -0.08194918185472488, -0.47594770789146423, -0.40932703018188477, -0.507302463054657, 1.4009032249450684, 0.580125093460083, 0.5517297983169556, -0.23241743445396423, -0.43901607394218445, -0.4518371820449829, 0.2528657615184784, -0.5759872198104858, -0.17445342242717743, 0.0962359681725502, 0.306217759847641, -0.4427953362464905, -0.0228814035654068, -0.13007840514183044, 0.49995461106300354, -0.18533946573734283, 0.20389944314956665, 0.21431533992290497, -0.3069710433483124, -0.4756218492984772, -0.14571534097194672, -0.5135357975959778, 0.2934885323047638, 0.47868576645851135, -0.2988058030605316, -0.06958859413862228, 0.44211792945861816, 0.20872096717357635, 0.12654505670070648, 0.3419244587421417, 0.4934438467025757, 0.5240862965583801, -0.014191520400345325, 0.18043428659439087, -0.3804997503757477, -0.1807672679424286, 0.1782374083995819, 0.08743958920240402, -0.01123176421970129, 0.35914146900177, -5.792445659637451, 0.031059978529810905, -0.1609167456626892, -0.5647792816162109, -0.1701406091451645, -0.3543972074985504, 0.9282260537147522, 0.2503061592578888, 0.445557564496994, 0.03973671793937683, 0.05101548135280609, 0.37937548756599426, -0.11139786243438721, -0.07725600898265839, -0.04433764889836311, 0.3617124855518341, -0.2522267997264862, -0.1138928160071373, 0.5756132006645203, -0.21605424582958221, 0.1139049157500267, -0.8146396279335022, 0.3902289867401123, 0.5742613673210144, -0.037689000368118286, 0.04718927666544914, -0.9231326580047607, -0.1555938422679901, -0.17290937900543213, -0.6312615871429443, -0.37605154514312744, -0.9618955850601196, -0.028865059837698936, -0.6340274214744568, 0.0984286442399025, -0.1997377574443817, 0.20250175893306732, -0.07977037131786346, -0.06346108019351959, -0.13506533205509186, 0.43197840452194214, -0.06175720691680908, 0.05817658454179764, -0.3503124713897705, 0.19118629395961761, -0.1874779611825943, 0.18006835877895355, 0.20396772027015686, -0.514311671257019, 0.8469225168228149, -0.1937209814786911, 0.18546132743358612, 0.23668049275875092, 0.3296106159687042, 0.4498187303543091, 0.048976507037878036, -0.2068210244178772, 0.07026249170303345, -0.9255507588386536, -0.0200541689991951, 0.18164260685443878, -0.23169326782226562, -0.3765312135219574, -0.9827682971954346, 0.18734543025493622, -0.0295997466892004, -1.1351324319839478, -0.08211609721183777, -0.14430958032608032, 0.23061570525169373, 0.10725808888673782, 0.21502025425434113, -0.048537760972976685, -0.5916634202003479, 0.22477401793003082, -0.32977327704429626, 0.28548866510391235, 0.19282345473766327, 0.07740390300750732, 0.10993307083845139, -0.6112769842147827, 0.22079911828041077, -0.3187063932418823, 0.19938963651657104, 0.1870875209569931, -0.48972904682159424, -0.89461749792099, -0.4410203695297241, -0.08011671900749207, 0.362261027097702, 0.6974542140960693, 0.04833415150642395, 0.21691161394119263, 0.8332130312919617, 0.13484156131744385, -0.41311684250831604, 0.20305748283863068, 0.7110090255737305, 0.4853079617023468, 0.03952087089419365, 0.8915591835975647, 0.6575057506561279, -0.27590212225914, -0.623241126537323, -0.5329551100730896, 0.1627662628889084, -0.39200714230537415, 0.11063181608915329, 0.7862693071365356, -0.5390031337738037, -0.13395953178405762, 0.030962323769927025, -0.5205248594284058, -0.38479939103126526, 0.5985201597213745, 0.2044842690229416, -0.5407439470291138, 0.12969233095645905, 0.8118858337402344, -0.32145458459854126, -0.07981044054031372, 0.011388864368200302, -0.5486431121826172, 0.8232467770576477, -0.23184572160243988, -0.3421880006790161, 0.5248405337333679, 0.37540459632873535, -1.030313491821289, -0.3603377640247345, 0.43462395668029785, 0.21390798687934875, -0.0657583698630333, -0.3629884123802185, 0.1628466546535492, -0.007517294492572546, -0.25104182958602905, 0.1791849136352539, 0.14171680808067322, -0.11457876861095428, -0.008046078495681286, -0.010338330641388893, 0.4437800645828247, 0.3351520299911499, 0.23272448778152466, 0.31329506635665894, 0.013319268822669983, 0.29683005809783936, -0.19659171998500824, 0.0803801417350769, 0.23395918309688568, -0.2601998448371887, 0.3063638210296631, -0.2921127676963806, -0.037017643451690674, 0.3582379221916199, 0.0015869186026975513, -0.17266938090324402, 0.5489537119865417, -0.06308487802743912, 0.13169269263744354, 0.2834872007369995, -0.3432512581348419, 0.0991152971982956, -0.3038448095321655, -0.10773993283510208, -0.10255620628595352, 0.13916181027889252, -0.5149320960044861, -0.09751146286725998, -0.09143585711717606, -0.27661189436912537, 0.1664675772190094, 0.19697514176368713, -0.1747410148382187, -0.5391263961791992, -0.1854196935892105, -0.008403654210269451, 0.32898369431495667, 0.2962600290775299, 0.12443112581968307, -0.49221137166023254, -0.012839107774198055, 0.3557199537754059, 0.7182734608650208, 0.35703450441360474, -0.444916307926178, -0.0297931469976902, -0.116452656686306, 0.11335102468729019, -0.1286020427942276, 0.13749802112579346, 0.07136310636997223, 0.051258280873298645, -0.11018099635839462, 0.21315352618694305, -0.41260993480682373, 0.7662055492401123, 0.2235548347234726, -0.3976099193096161, 0.025279633700847626, -0.2667015790939331, -0.06419473886489868, 0.3615291118621826, 0.6637991070747375, 0.2132769227027893, -0.09871944040060043, 0.40093547105789185, 0.10939554125070572, -0.27161648869514465, -0.12051240354776382, -0.7443405985832214, 0.017683792859315872, 0.2918245196342468, -0.06084650382399559, -0.21261100471019745, 0.4070013165473938, -0.4371681809425354, -0.3006081283092499, 0.4705066382884979, 0.15163679420948029, 0.13183516263961792, -0.09912655502557755, -0.42076772451400757, -0.3829655051231384, 0.26793816685676575, 0.11198096722364426, -0.6194770932197571, 0.3594118058681488, -0.04217754304409027, -0.04050905629992485, -0.27254730463027954, 0.2738402485847473, 0.18563556671142578, -0.25380241870880127, -0.21077744662761688, -0.14983658492565155, 0.12056583166122437, -0.25454583764076233, 0.581241250038147, 0.25584691762924194, 0.20195750892162323, -0.45504796504974365, 0.08652648329734802, 0.08680623769760132, 0.6185433864593506, -0.04848542809486389, -0.5602235794067383, -0.41403186321258545, -0.21843485534191132, 0.6210209131240845, -0.3949934244155884, 0.27248749136924744, 0.446865439414978, 1.272400140762329, 0.8298729062080383, 0.17169411480426788, -0.22482742369174957, -0.2777736186981201, 0.12185794115066528, -0.342167466878891, 0.17665089666843414, -0.12723179161548615, 0.31769803166389465, 0.5345458388328552, 0.2511114180088043, -0.1828588992357254, -0.25743719935417175, 0.5645204186439514, 0.01898955926299095, 0.3732975721359253, 0.023287838324904442, 0.6556183099746704, 0.23811893165111542, -0.5451027154922485, 0.2505471110343933, -0.21014279127120972, 0.5885757803916931, -0.2997176945209503, -0.033494237810373306, -0.7064061164855957, -0.26896050572395325, 0.7303960919380188, -0.11536918580532074, 0.3142460584640503, -0.5956413745880127, 0.03232147917151451, -0.7404753565788269, 0.5503008961677551, 0.1385975480079651, -0.22226780652999878, -0.22459425032138824, -0.8756544589996338, -0.08464410901069641, 0.08848410099744797, 0.27246952056884766, 0.5971905589103699, -0.07257573306560516, 0.01291212160140276, 0.49790555238723755, -0.7188539505004883, 0.3235297203063965, 0.5872174501419067, -0.7671590447425842, -0.04182739183306694, 0.5578286647796631, 0.4107791781425476, -0.2209426313638687, -0.6099942922592163, -0.1182403564453125, 0.3187764286994934, -0.038963738828897476, 0.4861232042312622, -0.050331246107816696, -0.13072100281715393, 0.05503905564546585, -0.4393417239189148, -0.4020576775074005, 0.15225984156131744, 0.0736660584807396, 0.33817970752716064, 0.5916991233825684, 0.31661534309387207, -0.028005201369524002, -0.0826541855931282, 0.027758026495575905, 0.4305192530155182, -0.35221174359321594, -0.4022992253303528, 0.6900907158851624, 0.3329925239086151, 0.45320960879325867, 0.11787739396095276, 0.8037616610527039, 0.20950965583324432, -0.20106469094753265, -0.20411242544651031, -0.5112091302871704, -0.06888027489185333, 0.10747383534908295, 0.6602871417999268, 0.5533787608146667, -0.3709251880645752, -0.31001582741737366, -0.14634515345096588, 0.3068762719631195, -0.0281367264688015, 0.42503494024276733, -0.253732830286026, 0.35999977588653564, 0.21786870062351227, -0.8242462873458862, -0.8053915500640869, 0.08632894605398178, -0.49617862701416016, 0.2933063209056854, 0.37145644426345825, -0.47404995560646057, -0.33471304178237915, 0.175849050283432, -0.9477166533470154, 0.4845857620239258, 0.5611343383789062, 0.5595778822898865, 0.12949560582637787, 0.3481457233428955, 0.6780562400817871, -0.0871911272406578, 0.45749804377555847, -0.2422098070383072, 0.33134934306144714, -0.11313038319349289, -0.30038389563560486, -0.49830520153045654, -0.21606002748012543, -0.3732832968235016, -0.16893792152404785, -0.24970006942749023, -0.10627740621566772, -0.24636800587177277, -0.7330704927444458, -0.343095600605011, 0.3853341341018677, -0.3945915699005127, 0.04710383713245392, -0.0449613556265831, -0.2880663275718689, -0.1307985484600067, 0.003759943414479494, 0.6291266679763794, 0.3397309184074402, -0.8845644593238831, 0.9945231080055237, -0.07993273437023163, 0.13570630550384521, 0.1927085965871811, -0.33581969141960144, 0.09199254959821701, 0.33411523699760437, 0.5090488791465759, 0.10550162941217422, 0.41689634323120117, 0.04028951749205589, -0.0590004101395607, -0.1235225647687912, 0.7247182726860046, -0.3024357855319977, -0.5289949774742126, -0.08149763196706772, -0.06677074730396271, 0.9933054447174072, 0.43853843212127686, -0.35557129979133606, 0.3794327676296234, 0.09907913208007812, 0.29005101323127747, 0.5843203663825989, -0.44247475266456604, -0.10599552094936371, -0.08569277822971344, -0.37935304641723633, -0.16509614884853363, 0.38964158296585083, 0.18031658232212067, -0.6254931688308716, 0.2657932639122009, 0.5513375401496887, 0.6856295466423035, -0.5816507935523987, 0.3602227568626404, -0.21762457489967346, 0.07624928653240204, -0.46105435490608215, 0.3215183615684509, -0.4053303003311157, 0.26611077785491943, -0.315186083316803, -0.10385128110647202, -0.18767520785331726, -0.17057554423809052, 0.2403387725353241, 0.4155888259410858, -0.001050077611580491, 0.02137008309364319, 0.3257860839366913, 0.33532196283340454, -0.10055039823055267, -0.8644635081291199, -1.0422382354736328, -0.5198273062705994, 0.0771031379699707, -0.33567312359809875, -0.07356975227594376, 0.27013012766838074, -0.08674739301204681, -0.3204697072505951, 0.4943596422672272, -0.32395803928375244, -0.2534402012825012, 0.5343132615089417 ]
Epithelial-mesenchymal transition (EMT) is implicated in converting stationary epithelial tumor cells into motile mesenchymal cells during metastasis. However, the involvement of EMT in metastasis is still controversial, due to the lack of a mesenchymal phenotype in human carcinoma metastases. Using a spontaneous squamous cell carcinoma mouse model, we show that activation of the EMT-inducing transcription factor Twist1 is sufficient to promote carcinoma cells to undergo EMT and disseminate into blood circulation. Importantly, in distant sites, turning off Twist1 to allow reversion of EMT is essential for disseminated tumor cells to proliferate and form metastases. Our study demonstrates in vivo the requirement of "reversible EMT" in tumor metastasis and may resolve the controversy on the importance of EMT in carcinoma metastasis.
[ -0.008410501293838024, 0.007067671976983547, -0.012489471584558487, 0.014986827038228512, 0.014428960159420967, -0.0031613206956535578, 0.012484961189329624, -0.0063615040853619576, -0.011991459876298904, -0.032411541789770126, -0.02024509198963642, 0.009978299960494041, -0.005576723720878363, 0.01472591981291771, -0.02399967610836029, -0.0007374342530965805, -0.02672695182263851, -0.006339441053569317, 0.010814078152179718, 0.00781308300793171, -0.031165700405836105, 0.009646114893257618, 0.010193310678005219, 0.013479983434081078, 0.01003687921911478, 0.02336898446083069, 0.017385002225637436, -0.03304770588874817, 0.009596156887710094, 0.0004764767363667488, -0.007257952820509672, 0.009903672151267529, 0.024569248780608177, -0.001715660560876131, 0.012338145636022091, -0.0069059208035469055, 0.00044287281343713403, 0.03164186701178551, 0.031425729393959045, -0.005905380472540855, 0.025191588327288628, -0.006516316439956427, 0.005936400964856148, -0.0011838995851576328, -0.005824762396514416, 0.0039803460240364075, 0.0029160473495721817, -0.011513795703649521, 0.0023996850941330194, 0.006007418967783451, -0.007861893624067307, -0.00423228507861495, -0.007049983367323875, -0.007642325479537249, -0.0070257061161100864, -0.006164142396301031, 0.017444303259253502, -0.018699925392866135, -0.014269896782934666, -0.02874506451189518, 0.019078876823186874, -0.01447172649204731, 0.03658892959356308, -0.005741639528423548, -0.008868123404681683, -0.06675426661968231, 0.03518633544445038, -0.006172726862132549, -0.008840947411954403, 0.01577516458928585, -0.002857828978449106, 0.007443695794790983, 0.01419057510793209, -0.012190666981041431, 0.008981936611235142, 0.008429945446550846, -0.02669035643339157, 0.015063908882439137, 0.02272825688123703, 0.012386512011289597, 0.04065833240747452, -0.007835308089852333, -0.001296008937060833, 0.015918385237455368, -0.00002973969094455242, 0.006308855954557657, -0.006661632098257542, 0.034236595034599304, 0.02183292806148529, -0.007965048775076866, -0.018454141914844513, 0.018888965249061584, -0.021351803094148636, -0.00791931338608265, -0.014542177319526672, 0.020129282027482986, 0.0057359011843800545, 0.0011101262643933296, 0.012433074414730072, 0.043183833360672, -0.01028138492256403, 0.013896397314965725, 0.027394909411668777, 0.04054654389619827, 0.0015108240768313408, 0.0098815793171525, -0.012203570455312729, 0.016764894127845764, 0.03374321758747101, 0.013225303962826729, 0.010276293382048607, -0.02066422812640667, -0.0021327612921595573, 0.0038389754481613636, 0.005601781420409679, -0.05398102104663849, -0.0011928308522328734, -0.0046982732601463795, 0.017241446301341057, 0.001113802194595337, -0.0019622896797955036, -0.001724399859085679, -0.0039299121126532555, -0.012936463579535484, 0.002840153407305479, -0.007265501655638218, -0.04184945300221443, 0.012591220438480377, 0.002895020879805088, -0.008404938504099846, -0.009522662498056889, -0.000791285652667284, -0.005608212202787399, -0.01889338716864586, 0.005249167792499065, 0.0028006741777062416, -0.019605837762355804, 0.006752485409379005, 0.003229475114494562, -0.016555214300751686, 0.024724824354052544, 0.012787928804755211, 0.004860724322497845, 0.008647104725241661, -0.0034902323968708515, 0.002484358614310622, -0.006137714255601168, 0.00736047700047493, -0.018609579652547836, -0.030098747462034225, 0.00528397411108017, -0.0054051754996180534, -0.01759711652994156, -0.001959818648174405, -0.0004975213669240475, 0.0006377319805324078, -0.015684768557548523, 0.010757606476545334, 0.00252934661693871, 0.001686342409811914, -0.023942865431308746, 0.00037262076511979103, -0.006531615275889635, 0.009018425829708576, 0.009288018569350243, -0.030318934470415115, -0.005528628826141357, -0.0008045552531257272, 0.000027235597372055054, 0.003353159874677658, -0.002769201062619686, -0.012128934264183044, 0.0013133320026099682, 0.004995652474462986, 0.004750269465148449, -0.006886079907417297, 0.018825657665729523, 0.006156072951853275, -0.023177023977041245, 0.0668574720621109, -0.00925503857433796, 0.011172624304890633, -0.0017725471407175064, 0.00704761128872633, -0.01625622808933258, -0.0061297230422496796, 0.024997945874929428, 0.0047556012868881226, 0.0178756732493639, 0.004084115847945213, 0.0014744158834218979, 0.0032405820675194263, -0.015244536101818085, 0.0046682702377438545, -0.0137962456792593, 0.004205858334898949, 0.002016062382608652, 0.013751143589615822, -0.0017691440880298615, -0.006298143416643143, 0.013512829318642616, -0.031188512220978737, 0.030634865164756775, 0.011662266217172146, 0.012419764883816242, 0.018327217549085617, 0.029049966484308243, -0.03328878432512283, 0.002034557517617941, -0.003021213226020336, 0.028373369947075844, 0.006211217492818832, -0.015949642285704613, 0.0008708138484507799, 0.02714555896818638, 0.018897362053394318, -0.010149111971259117, 0.03205450624227524, -0.0015952568501234055, -0.010192236863076687, -0.006338769569993019, 0.00392352556809783, 0.023849215358495712, -0.001966143026947975, 0.023445509374141693, -0.007997201755642891, -0.0008359877392649651, 0.010635768994688988, 0.019544195383787155, -0.0017630592919886112, -0.025857683271169662, -0.021453412249684334, -0.010435115545988083, 0.029122503474354744, 0.019370153546333313, -0.015942789614200592, 0.009784352034330368, -0.024964511394500732, 0.018246300518512726, -0.014988837763667107, -0.011531101539731026, -0.013230385258793831, 0.014506852254271507, -0.025417346507310867, 0.0022323369048535824, 0.025091536343097687, 0.02605292573571205, 0.009782621636986732, -0.0009219872299581766, -0.010408164002001286, 0.010657060891389847, -0.018549876287579536, 0.00039762514643371105, 0.008957741782069206, 0.005924424156546593, -0.03779664635658264, -0.0018814397044479847, 0.014096925035119057, 0.027974218130111694, 0.006709042936563492, 0.00099166517611593, 0.006788601167500019, 0.0002747857943177223, -0.008366516791284084, -0.004014625214040279, -0.022775107994675636, 0.01082709152251482, 0.00017889123409986496, 0.018288629129529, 0.0004688316257670522, 0.0037577077746391296, -0.0012278133071959019, -0.005810892675071955, -0.08166494965553284, -0.01028222031891346, 0.004070675000548363, -0.013816806487739086, 0.005382091738283634, -0.011347070336341858, 0.005713240709155798, 0.004731527529656887, -0.009210948832333088, -0.009255193173885345, 0.00813223421573639, 0.0015945137711241841, -0.008474516682326794, -0.019731320440769196, -0.04364064335823059, -0.002394402399659157, 0.00906067993491888, -0.006676636636257172, 0.007968222722411156, -0.01327609084546566, 0.027069006115198135, -0.0075723822228610516, 0.014006899669766426, 0.008470382541418076, -0.004427703097462654, 0.03605898469686508, 0.0003906521014869213, 0.0026746641378849745, -0.02696247398853302, 0.0031477357260882854, -0.003151846118271351, -0.01141408085823059, 0.0005953446961939335, -0.004100808873772621, -0.005847459193319082, 0.006489376071840525, -0.003933166153728962, 0.0010439548641443253, -0.0032481099478900433, 0.03244216740131378, -0.009259823709726334, 0.015036770142614841, 0.009438344277441502, -0.009550809860229492, 0.013644961640238762, 0.012837802991271019, 0.005862087942659855, -0.05567840859293938, 0.012445151805877686, 0.006325563881546259, 0.004050223156809807, 0.0038455119356513023, -0.016372274607419968, 0.02589436061680317, -0.011506822891533375, -0.019035058096051216, -0.020819537341594696, -0.021326912567019463, -0.011371433734893799, -0.009970100596547127, 0.025794439017772675, 0.012641701847314835, -0.0023244384210556746, 0.012728743255138397, -0.016973383724689484, 0.028825636953115463, 0.00734356977045536, 0.0014795016031712294, -0.011413783766329288, 0.009586368687450886, 0.0023807641118764877, 0.0047678761184215546, 0.004922489635646343, -0.005925297737121582, -0.021370962262153625, -0.0060143969021737576, -0.010622605681419373, -0.01160628255456686, 0.00126578938215971, -0.000018152757547795773, -0.03039451874792576, -0.014920145273208618, -0.010944101959466934, 0.0054183900356292725, -0.02047850377857685, -0.023460539057850838, 0.009332245215773582, 0.06245507672429085, 0.011201219633221626, -0.016396749764680862, 0.020207680761814117, 0.006322301924228668, -0.002402536105364561, 0.008977063931524754, -0.022339999675750732, -0.03276173770427704, 0.0069641959853470325, -0.0197015181183815, 0.03904406726360321, 0.00914112851023674, -0.013877267017960548, -0.011483995243906975, 0.02182966098189354, -0.01072714850306511, -0.015448490157723427, 0.01106821745634079, 0.013279382139444351, 0.0004284667083993554, 0.0017696910072118044, -0.004187366925179958, -0.018624093383550644, -0.014011826366186142, -0.005634371656924486, 0.040565572679042816, 0.011930091306567192, 0.027563365176320076, -0.0010595889762043953, -0.04088851064443588, 0.07172834873199463, -0.010864208452403545, -0.006819861941039562, -0.025207865983247757, 0.021204795688390732, -0.030324695631861687, -0.0029373285360634327, 0.0049584247171878815, -0.036952126771211624, 0.012022589333355427, 0.014892453327775002, 0.01562332920730114, 0.027760181576013565, 0.009911609813570976, -0.03275731950998306, 0.004042899701744318, -0.020250771194696426, -0.023687303066253662, -0.0005022818222641945, -0.006005133036524057, 0.03050164319574833, -0.011756090447306633, -0.027635348960757256, 0.0004255562089383602, 0.015779398381710052, 0.009317224845290184, 0.011007989756762981, -0.01720532402396202, -0.019122034311294556, 0.0035494272597134113, -0.01329712849110365, -0.02326618693768978, -0.003088458441197872, -0.0008403416723012924, 0.01386966835707426, 0.0015892940573394299, -0.01212911494076252, 0.009343627840280533, -0.00839253980666399, 0.010241130366921425, -0.007794605568051338, -0.010510671883821487, 0.003080218331888318, 0.01818036288022995, 0.011985594406723976, -0.019593670964241028, 0.04040488600730896, -0.008323770947754383, -0.006460465490818024, -0.007315547205507755, -0.025628162547945976, 0.002352673327550292, 0.018427519127726555, 0.022841650992631912, -0.01558392308652401, 0.0197974294424057, 0.01045497041195631, -0.0013373936526477337, 0.026014510542154312, 0.0026317304000258446, -0.03155915439128876, -0.008586505427956581, 0.02399739809334278, -0.03354222699999809, 0.013192245736718178, -0.005877117160707712, -0.03379364684224129, -0.010442939586937428, 0.02670784294605255, -0.011786889284849167, 0.03984386473894119, -0.01119965873658657, -0.009592201560735703, -0.039635736495256424, -0.019945884123444557, 0.03832927346229553, -0.026943612843751907, -0.009360140189528465, 0.024807021021842957, 0.019447140395641327, -0.00388907128944993, -0.0033823209814727306, -0.008319837972521782, 0.011642245575785637, 0.03110090270638466, -0.0031904932111501694, 0.007689711172133684, -0.07492657005786896, -0.01652149297297001, 0.007195361889898777, -0.007783897221088409, -0.004905174486339092, -0.021394409239292145, -0.01961854100227356, -0.010945216752588749, -0.0029342034831643105, -0.006152195390313864, 0.022301234304904938, -0.0039339917711913586, -0.02273014560341835, -0.0008273867424577475, 0.009656533598899841, 0.015442627482116222, 0.010541942901909351, -0.023524343967437744, -0.030212298035621643, 0.0014609475620090961, 0.006626593414694071, -0.006424674764275551, 0.00009914208203554153, -0.0007449674885720015, -0.0008100571576505899, -0.08048389852046967, 0.03876926749944687, -0.027897212654352188, -0.026123996824026108, 0.002746117301285267, -0.005165577866137028, 0.013978039845824242, -0.011022786609828472, -0.024294108152389526, -0.015948433429002762, -0.0019353185780346394, 0.014359792694449425, 0.02339264750480652, 0.006037128623574972, 0.01686985231935978, -0.01078527420759201, 0.01144576258957386, -0.008484733290970325, -0.009226718917489052, -0.02967110462486744, 0.001589063904248178, 0.014766610227525234, -0.008456425741314888, -0.034540772438049316, -0.014246281236410141, 0.017452532425522804, 0.019124280661344528, 0.011655709706246853, 0.006191499065607786, 0.006296563893556595, -0.0021970656234771013, -0.007875061593949795, -0.008211635053157806, 0.004949369467794895, -0.017852474004030228, -0.02225312776863575, -0.004918712191283703, 0.0022428734228014946, -0.015341633930802345, 0.014545309357345104, -0.0064156390726566315, 0.012319877743721008, -0.007915733382105827, 0.0030531350057572126, -0.0073770638555288315, 0.02002602629363537, 0.004733050242066383, -0.010034056380391121, 0.014438540674746037, -0.0002259276807308197, 0.00020274490816518664, 0.0051918597891926765, -0.018494481220841408, 0.01591886766254902, -0.006160334683954716, 0.008435387164354324, -0.0002531579229980707, -0.003176262602210045, 0.022488228976726532, 0.013361419551074505, -0.017939411103725433, 0.012002190575003624, -0.004205635283142328, 0.0717095360159874, 0.001470648916438222, 0.02513638511300087, -0.012547696009278297, -0.0018684584647417068, 0.003960087895393372, -0.02988341823220253, -0.01724916882812977, -0.026590345427393913, -0.0013799325097352266, 0.018239714205265045, -0.014134649187326431, -0.003659588284790516, 0.009507972747087479, 0.015864429995417595, -0.025981726124882698, -0.007162871770560741, 0.01520643662661314, 0.0022205738350749016, 0.0074583617970347404, -0.00347883440554142, -0.005614087916910648, -0.015376748517155647, -0.0038391954731196165, 0.01267101988196373, -0.0012788661988452077, -0.03978106006979942, 0.0064417412504553795, -0.012003320269286633, 0.0033549307845532894, -0.002730563748627901, 0.022973671555519104, -0.0015540193999186158, 0.006359707564115524, 0.027103502303361893, 0.0390666127204895, -0.0014427700079977512, 0.0012857833644375205, 0.0026508329901844263, -0.0040242113173007965, 0.01999741978943348, -0.009077832102775574, 0.006549073848873377, -0.010479980148375034, -0.013492314144968987, -0.008225719444453716, -0.013632586225867271, -0.022454923018813133, -0.016004160046577454, 0.00706546101719141, 0.005875748582184315, 0.008860372006893158, -0.01346094161272049, 0.012136796489357948, 0.012485582381486893, 0.003350031329318881, 0.015968870371580124, 0.01911870762705803, 0.0023119745310395956, -0.002281120279803872, 0.010326620191335678, -0.009539343416690826, -0.020706769078969955, -0.023488489910960197, 0.020762715488672256, 0.0189726073294878, 0.022608762606978416, -0.018218083307147026, 0.019149452447891235, 0.017901921644806862, -0.016082745045423508, 0.004917306825518608, 0.006874237675219774, -0.013907227665185928, 0.02202821895480156, -0.005391635000705719, -0.005856717471033335, 0.005737124942243099, 0.011993538588285446, 0.018335983157157898, -0.007540605496615171, 0.01466076448559761, -0.016384530812501907, 0.009793807752430439, -0.009508354589343071, -0.017613418400287628, 0.013724811375141144, -0.00009706174023449421, -0.001626079436391592, 0.017784835770726204, 0.028752055019140244, 0.0041700368747115135, 0.00003959517925977707, 0.032951533794403076, 0.003960750065743923, 0.036485590040683746, 0.006830754689872265, 0.0038407070096582174, -0.011911394074559212, 0.014671196229755878, 0.008142931386828423, -0.010159860365092754, -0.0226619690656662, -0.03710266575217247, -0.028150368481874466, -0.010391400195658207, -0.021046267822384834, -0.010543535463511944, -0.013175373896956444, -0.0077759502455592155, 0.00975415762513876, -0.007547799032181501, 0.031025057658553123, 0.01295586209744215, -0.0029771337285637856, -0.0012319688685238361, -0.012584383599460125, 0.021433889865875244, 0.006480420473963022, -0.005110957194119692, -0.02323889546096325, -0.02378474548459053, -0.03171820193529129, 0.022020045667886734, -0.02796226739883423, -0.003471347503364086, -0.008011231198906898, 0.0292035099118948, -0.03818003088235855, -0.004653045907616615, 0.02110476978123188, -0.02300690859556198, -0.024300649762153625, 0.02210516482591629, -0.005828411318361759, 0.029298070818185806, -0.008943790569901466, -0.010501349344849586, -0.006817481946200132, 0.03635850548744202, 0.04973190277814865, -0.006705984473228455, 0.001685209572315216, -0.017283037304878235, 0.006913269404321909, 0.002548476215451956, 0.008258932270109653, 0.006975236814469099, 0.009071310982108116, -0.005889981985092163, 0.00512648792937398, 0.03342974931001663, 0.013824204914271832, -0.006995496340095997, 0.011872556060552597, 0.021251022815704346, 0.004334135912358761, 0.017988143488764763, 0.0070028966292738914, -0.021086055785417557, -0.003819528967142105, 0.0026015201583504677, 0.011699703522026539, -0.013065855018794537, 0.020807428285479546, 0.0034394944086670876, -0.041814159601926804, 0.00534400437027216, -0.007758825086057186, 0.016285184770822525, -0.016390200704336166, 0.018481571227312088, -0.012830685824155807, 0.00213914318010211, -0.03030727431178093, -0.007585776969790459, 0.005072277970612049, -0.006344921886920929, 0.0020018110517412424, 0.0038501303642988205, -0.000014399411156773567, 0.0019184299744665623, -0.0009592005517333746, -0.005397273227572441, 0.006411019712686539, 0.014473607763648033, -0.013367731124162674, 0.002596228616312146, 0.010220367461442947, 0.0006269675213843584, 0.0025439979508519173, -0.012680789455771446, -0.010507266968488693, -0.0008066489826887846, 0.0028770435601472855, 0.0024700388312339783, 0.04301398992538452, -0.056003376841545105, -0.0014753196155652404, -0.0015386745799332857, 0.01115323230624199, -0.02342873439192772 ]
[ -0.02924606390297413, -0.31626641750335693, 0.45841097831726074, 0.16886945068836212, 0.26108503341674805, 0.1426774114370346, 0.20490075647830963, -0.07457005232572556, -0.1377570927143097, -0.9462941884994507, -0.10012605786323547, 0.5063779950141907, -0.27349358797073364, 0.028262903913855553, -0.12319907546043396, 0.2588002383708954, 0.3180353045463562, 0.2716348469257355, -0.2988579571247101, -0.5296729803085327, -0.16764244437217712, -0.29058194160461426, 0.4409627914428711, -0.15291494131088257, 0.2642475962638855, -0.43334266543388367, -0.07273007184267044, -0.456026554107666, 0.5667121410369873, -0.049260903149843216, -0.03381036967039108, 0.3073447346687317, -0.11535163223743439, -0.25759488344192505, -0.2567310035228729, 0.2446519434452057, -0.32757803797721863, -0.1038132980465889, 0.02525070682168007, -0.30810225009918213, -0.7658714056015015, -0.3587811291217804, 0.2307463139295578, 0.3147127330303192, -0.267706036567688, -0.17894011735916138, -1.6440281867980957, 0.2984088063240051, -0.5995769500732422, 0.30496037006378174, 0.18677450716495514, -0.012899305671453476, 0.27511560916900635, 0.4377835988998413, 0.6903313994407654, -0.04362351447343826, -1.1048977375030518, 0.17468853294849396, 0.3905719518661499, -0.12667551636695862, -0.20974698662757874, 0.1578928679227829, -0.4517394006252289, 0.14352107048034668, 0.05019561946392059, 0.5535172820091248, 0.19362850487232208, -0.5389267206192017, -0.30448344349861145, -0.14163176715373993, 0.09660790115594864, -0.6310635805130005, 0.07369227707386017, 0.5214830636978149, 0.3389776349067688, -0.46500954031944275, -0.39287567138671875, -0.25772711634635925, 0.2849663197994232, 0.40547922253608704, 0.036599088460206985, 0.5011201500892639, 0.37451300024986267, 0.14185184240341187, 0.6011287569999695, 0.004414149094372988, -0.2430146038532257, 0.8873719573020935, -0.7487240433692932, -0.11386025696992874, -0.0870070680975914, -0.2929927408695221, 0.24987900257110596, 0.3050557076931, 0.19141876697540283, 0.31422504782676697, 0.1559116244316101, -0.1497509479522705, -0.1608193814754486, 0.1811426728963852, 0.23410090804100037, 0.3146767318248749, -0.11363023519515991, -0.6489338874816895, -0.2987440824508667, -0.27265268564224243, -0.1446043998003006, -0.3503887355327606, -0.3680277168750763, -0.13740845024585724, -0.9844915866851807, 0.12215886265039444, -0.2168571501970291, -0.1275993138551712, 0.02646665833890438, 0.340955525636673, 0.364810973405838, -0.19223423302173615, 0.21881414949893951, 0.09182737022638321, 0.11227575689554214, 0.9578330516815186, 0.16860464215278625, 0.6100866198539734, -0.00712599279358983, -0.07272334396839142, 0.28234121203422546, 0.3971448838710785, -0.2949313223361969, 1.0271246433258057, 0.1960190385580063, 0.6541135311126709, -0.21631594002246857, -0.11767920106649399, 0.3861737549304962, 0.2398972511291504, 0.4800466299057007, 0.47883424162864685, 0.47805702686309814, 0.42398035526275635, -0.40895017981529236, -0.19225871562957764, -0.22126904129981995, -0.1835225522518158, -0.30941176414489746, -0.5434578657150269, -0.0649719312787056, 0.21335089206695557, -0.02629820443689823, -0.021042607724666595, 0.004908126313239336, -0.20437012612819672, -0.1834956407546997, 0.03917975351214409, 0.03171808645129204, 0.4768965244293213, 0.06441541016101837, -0.05683949217200279, -0.11597836762666702, 0.21264640986919403, 0.05114637315273285, 0.022546380758285522, -0.03932391479611397, -0.1957217901945114, 0.4703221321105957, -0.004313505254685879, 0.05984460189938545, 0.3637714982032776, 0.3950716555118561, -0.029732905328273773, -0.04872390255331993, -0.32481658458709717, -0.27297475934028625, -0.3249346613883972, 0.015672167763113976, 0.3106157183647156, 0.5536385774612427, 0.20722301304340363, 0.08967781811952591, -0.09440241008996964, -0.9985209703445435, 0.5550565123558044, 0.051508184522390366, -0.769629955291748, -0.269361287355423, 0.1715223491191864, 0.5258452892303467, -0.07836289703845978, -0.32438865303993225, 0.30229082703590393, 0.2489735335111618, 0.012130479328334332, 0.5728038549423218, -0.6709513068199158, 0.9861999750137329, 0.10581274330615997, -0.35661521553993225, 0.8789474368095398, -0.011148209683597088, 0.2195066511631012, 0.13337935507297516, -0.10100562870502472, 0.7610554099082947, -0.3597422242164612, -0.3588274419307709, 0.004447076469659805, -0.1307317316532135, -0.20508445799350739, 0.12440795451402664, 0.059066567569971085, 0.44415172934532166, -0.3606068193912506, 0.004747415892779827, 0.15283715724945068, 0.1646791398525238, -0.8402057886123657, -0.10944963991641998, -0.5076460838317871, -0.2516885995864868, -0.013467594981193542, 0.11686495691537857, -0.4592745304107666, 0.7913414835929871, 0.4512268006801605, 0.3906537592411041, 0.6482346057891846, 0.4079917073249817, 0.3843688666820526, 0.982761561870575, 0.030772102996706963, -0.07836302369832993, -0.4487176537513733, 0.13087117671966553, -0.26862725615501404, 0.21900977194309235, -0.07174362242221832, 0.45996010303497314, -0.5896315574645996, 0.1547355204820633, 0.01837865263223648, -0.24885280430316925, 0.3729463517665863, -0.3441717326641083, -0.09030449390411377, 0.2653477191925049, -0.25964421033859253, -0.2756604850292206, -0.034684453159570694, -0.943450391292572, 0.05158817023038864, -0.4004686772823334, 0.1231512501835823, -0.1409488320350647, -0.7222061157226562, 0.10875416547060013, -0.1265689879655838, -0.2630345821380615, 0.15626958012580872, -0.3844369649887085, -0.3777056038379669, -0.2682904005050659, -0.2520594596862793, 0.34382402896881104, 0.5330759286880493, -0.09308824688196182, -0.7847232818603516, -0.9439913034439087, 0.014389526098966599, 0.9230161309242249, 0.5169621706008911, 1.0456554889678955, -0.10264730453491211, -0.5032832026481628, -0.36623838543891907, -0.4288274943828583, -0.6525942087173462, -0.2478865683078766, 0.9305021166801453, -0.3773389756679535, -0.373911052942276, 0.08157579600811005, 0.5930013656616211, 0.7531852722167969, 0.09595821052789688, -0.24451830983161926, 0.27646172046661377, -0.3407113552093506, -0.47810256481170654, -0.35592418909072876, -0.7626919150352478, 0.013982433825731277, 0.4995139539241791, -0.12105491012334824, 0.1478269100189209, 0.5188902020454407, 0.06737100332975388, 0.22022724151611328, 0.529180109500885, 0.4450695216655731, -0.1594642549753189, -0.021149083971977234, 0.34333139657974243, -0.25328516960144043, -0.06489337235689163, -0.056679774075746536, -0.08630681782960892, -0.13618361949920654, -0.09328579157590866, -5.72136926651001, 0.04283430427312851, 0.13172712922096252, -0.4582047164440155, 0.26086166501045227, -0.47270604968070984, 1.3009055852890015, 0.301801472902298, 0.1726456880569458, 0.5517358779907227, 0.33951011300086975, 0.37276703119277954, -0.006047594361007214, -0.05241457000374794, -0.3929270803928375, -0.16303451359272003, -0.22157242894172668, -0.2974753677845001, 0.6190750598907471, -0.16463445127010345, -0.027916841208934784, -0.9911231398582458, 0.3520934581756592, 0.8400914072990417, -0.0360223688185215, -0.5363626480102539, -0.5797751545906067, 0.055777642875909805, -0.2436743527650833, -0.37676721811294556, 0.2204180508852005, -0.37696021795272827, 0.20307563245296478, -0.1267487108707428, 0.3786153793334961, -0.08723688870668411, 0.36394163966178894, 0.10825120657682419, -0.46104148030281067, -0.5555654168128967, 0.15103250741958618, 0.30034226179122925, -0.00638975203037262, -0.38504156470298767, 0.10023605078458786, -0.26438239216804504, 0.38583138585090637, 0.093351811170578, -0.07100667804479599, 0.8519449830055237, 0.16592207551002502, -0.39043524861335754, 0.294706255197525, 0.4761618375778198, 0.7686792612075806, 0.31262582540512085, -0.26843026280403137, 0.10657867789268494, -0.3450511395931244, 0.14638572931289673, -0.5005283355712891, -0.15519772469997406, -0.4696454703807831, -0.8562589287757874, 0.5276904106140137, 0.2386944442987442, -1.0375347137451172, -0.041341956704854965, 0.9578404426574707, -0.15096430480480194, -0.22105242311954498, -0.16349880397319794, 0.20255808532238007, -0.7463487982749939, 0.41673222184181213, -0.2353098839521408, 0.42011433839797974, -0.1782560795545578, -0.09447535127401352, -0.2450251430273056, -0.15072757005691528, -0.10906896740198135, -0.0073204622603952885, -0.27043095231056213, 0.1257622390985489, 0.24003803730010986, -0.40031614899635315, 0.005118704866617918, 0.0615297369658947, 0.27157148718833923, 0.3205176293849945, 0.28583472967147827, -0.1342533975839615, 0.2122637778520584, -0.013498268090188503, -0.04419620707631111, -0.00010587279393803328, 0.8452454209327698, 0.25855308771133423, -0.29111215472221375, 0.5627548098564148, -0.14132191240787506, 0.021932097151875496, -0.3620944321155548, -0.00550035247579217, 0.3859667479991913, -0.5060640573501587, -0.21521994471549988, 0.6546348333358765, -1.071292757987976, 0.009447949007153511, 0.1023036390542984, -0.3618340790271759, -0.31651705503463745, 0.4388851225376129, -0.13355030119419098, -0.39991816878318787, -0.32115381956100464, 0.8670909404754639, -0.46604466438293457, 0.3984324038028717, 0.4718326926231384, -0.7910545468330383, 0.11742879450321198, 0.09191286563873291, -0.04906723275780678, 0.003909575752913952, 1.3781412839889526, -0.5476595759391785, -0.2813333570957184, 0.2676081657409668, 0.2520708441734314, -0.4232605993747711, -0.02500728890299797, -0.015529562719166279, -0.2852078080177307, -0.2247527688741684, 0.47732144594192505, 0.31551316380500793, 0.08638399094343185, 0.2858133018016815, -0.7785079479217529, -0.12339254468679428, -0.018373170867562294, 0.41120246052742004, 0.06265149265527725, -0.2953212261199951, 0.10419536381959915, -0.5345587730407715, 0.0904245376586914, 0.4836336672306061, -0.27853110432624817, 0.06802871823310852, -0.24615062773227692, -0.0964021161198616, 0.6196905970573425, 0.34839966893196106, 0.15968438982963562, 0.3550797700881958, -0.7479474544525146, 0.11303049325942993, 0.6135824918746948, -0.7281724810600281, -0.25063183903694153, -0.07735021412372589, -0.20416668057441711, -0.20576125383377075, -0.4417490065097809, -0.3070094883441925, -0.08286198228597641, -0.2935910224914551, -0.23291802406311035, -0.29833826422691345, -0.07731828093528748, 0.3298737704753876, -0.10024815797805786, -0.4967992603778839, 0.33104708790779114, -0.08539924025535583, -0.4263702929019928, 0.28668907284736633, -0.502392053604126, -0.061923664063215256, -0.1692514717578888, 0.495821475982666, -0.39953380823135376, 0.07965288311243057, -0.46414414048194885, -0.2547307014465332, -0.45324280858039856, 0.41945797204971313, 0.3759540915489197, -0.41481783986091614, -0.23040546476840973, 0.28270065784454346, 0.16330167651176453, -0.2234289050102234, 0.3993855118751526, 0.060222022235393524, -0.6587520241737366, 0.48826006054878235, 0.35480302572250366, -0.15132008492946625, 0.6909807324409485, 0.6134802103042603, -0.18285880982875824, -0.06939244270324707, 0.194106325507164, -0.25259295105934143, -0.566918671131134, 0.3470340669155121, -0.7151590585708618, 0.17000308632850647, 0.39022496342658997, -0.23838791251182556, -0.28543704748153687, 0.4944884181022644, -0.29604053497314453, -0.23869110643863678, 0.45568934082984924, 0.5201692581176758, 0.1767609417438507, 0.1506335288286209, 0.11661231517791748, -0.8271054029464722, 0.16737230122089386, 0.8901029229164124, -0.853764533996582, 0.2775179147720337, -0.006667090579867363, 0.01948818564414978, -0.11848805844783783, -0.37899667024612427, 0.4019024074077606, 0.026892129331827164, -0.286307692527771, -0.2588053345680237, -0.20875269174575806, -0.19418257474899292, 0.16099309921264648, 0.09672793745994568, 0.45007655024528503, -0.43534645438194275, -0.12765491008758545, -0.14603501558303833, 1.0454810857772827, 0.23838886618614197, -1.0104554891586304, -0.41370275616645813, 0.30604586005210876, 0.17939865589141846, -0.056725986301898956, 0.3699778914451599, 0.3385133743286133, 0.9251161813735962, -0.029837660491466522, -0.16687583923339844, -0.2412235587835312, -0.2947373390197754, 0.04261138290166855, -0.6672928333282471, -0.3704701364040375, -0.11503086984157562, 0.07240115851163864, 0.2676493525505066, -0.1315627247095108, -0.33100059628486633, -0.4818393588066101, 0.056578103452920914, -0.33185774087905884, -0.4554002285003662, -0.32506874203681946, 0.652840793132782, -0.21415556967258453, 0.14798563718795776, -0.12465047091245651, 0.015304352156817913, -0.4792426526546478, 0.052550286054611206, 0.13728374242782593, -0.25021126866340637, -0.8533134460449219, 0.3184642195701599, -0.10701365023851395, 0.15093688666820526, -0.7059371471405029, 0.43787720799446106, -0.8173848390579224, -0.3622185289859772, -0.32655787467956543, 0.07322219014167786, 0.4465855062007904, -0.16593363881111145, -0.39728158712387085, 0.14647053182125092, 0.3050081729888916, 0.2688560485839844, 0.35828593373298645, -0.0028746817260980606, -0.1945779174566269, -0.6176217198371887, 0.49933120608329773, 0.36261847615242004, -0.2693668603897095, -0.34536388516426086, 0.26389065384864807, 0.3345218896865845, 0.03481128439307213, -0.5186553001403809, -0.06968344002962112, 0.05162889137864113, 0.062110431492328644, 0.0798598974943161, 0.20063704252243042, 0.04045262932777405, 0.0682542696595192, 0.09917720407247543, -0.3522668480873108, 0.08627307415008545, 0.3037470877170563, 0.17851589620113373, 0.587469756603241, 0.5668739676475525, -0.01940278522670269, -0.01677780970931053, 0.17738214135169983, 0.5050128698348999, 0.36989447474479675, -0.25461864471435547, 0.7958571910858154, 1.0589299201965332, 0.4561322331428528, -0.07022447139024734, 0.9311902523040771, 0.7849298119544983, 0.24735088646411896, -0.1113356277346611, 0.09826498478651047, -0.512670636177063, 0.30783602595329285, 0.6839750409126282, 0.7535048127174377, -0.12573328614234924, -0.1864975392818451, 0.3835475742816925, 0.0738435909152031, -0.012592615559697151, 0.47044822573661804, -0.1967749446630478, 0.16722077131271362, 0.425178587436676, -0.6467825174331665, -0.33983245491981506, -0.5043581128120422, -0.6555705070495605, -0.05538589879870415, 0.38922786712646484, -0.3491784930229187, -0.4155041575431824, 0.11247541010379791, -0.37173551321029663, 0.030448947101831436, -0.05407733842730522, 0.6538838148117065, -0.24313051998615265, -0.12557126581668854, 0.47969552874565125, 0.0502617321908474, 0.31265369057655334, 0.12406843155622482, -0.007937213405966759, 0.15970925986766815, -0.13387301564216614, 0.2492212951183319, -0.12195220589637756, -0.5192522406578064, 0.19729837775230408, -0.24255841970443726, 0.2415403127670288, 0.2504032850265503, -0.3646845817565918, -0.04270826652646065, -0.017311492934823036, -0.7036122679710388, 0.08884245157241821, -0.19436289370059967, -0.1426328867673874, -0.00908498466014862, -0.35320037603378296, 0.5174155831336975, -0.04523242637515068, -0.35576891899108887, 0.3711830675601959, 0.0030509792268276215, -0.2939901351928711, 0.1944446563720703, -0.24527186155319214, 0.1350209265947342, 0.08475437760353088, 0.2422710657119751, -0.11054153740406036, 0.8846607804298401, -0.12399818003177643, 0.05055458843708038, -0.5725326538085938, 0.8625331521034241, -0.4421001970767975, -0.20380772650241852, -0.8253755569458008, -0.3858308494091034, 1.1435267925262451, 1.3640729188919067, -0.07642863690853119, -0.15041212737560272, 0.10693306475877762, -0.43622562289237976, 0.28122973442077637, -0.3187570571899414, -0.3715059161186218, -0.6003652811050415, -0.24904394149780273, -0.8412099480628967, 0.3887636959552765, 0.020036179572343826, -0.3696707785129547, -0.28714749217033386, 0.7508399486541748, 0.3278026878833771, -0.025210203602910042, 0.5911023616790771, 0.07093943655490875, 0.07421032339334488, -0.7830896973609924, 0.47431862354278564, -0.27882781624794006, 0.3195451498031616, -1.109068512916565, -0.10492800921201706, 0.0967647135257721, -0.07350949198007584, 0.34011733531951904, 0.10447902232408524, -0.22664859890937805, 0.1226433739066124, 0.06699886918067932, -0.4920414090156555, -0.06871572136878967, -0.658575713634491, -0.720626711845398, 0.03366563469171524, 0.1209251880645752, -0.9686277508735657, -0.11063022911548615, -0.047080639749765396, 0.07313654571771622, -0.09480176120996475, 0.11497707664966583, -0.30532509088516235, -0.2850293219089508, 0.1847361922264099 ]
Asymmetric cell division and apoptosis (programmed cell death) are two fundamental processes that are important for the development and function of multicellular organisms. We have found that the processes of asymmetric cell division and apoptosis can be functionally linked. Specifically, we show that asymmetric cell division in the nematode Caenorhabditis elegans is mediated by a pathway involving three genes, dnj-11 MIDA1, ces-2 HLF, and ces-1 Snail, that directly control the enzymatic machinery responsible for apoptosis. Interestingly, the MIDA1-like protein GlsA of the alga Volvox carteri, as well as the Snail-related proteins Snail, Escargot, and Worniu of Drosophila melanogaster, have previously been implicated in asymmetric cell division. Therefore, C. elegans dnj-11 MIDA1, ces-2 HLF, and ces-1 Snail may be components of a pathway involved in asymmetric cell division that is conserved throughout the plant and animal kingdoms. Furthermore, based on our results, we propose that this pathway directly controls the apoptotic fate in C. elegans, and possibly other animals as well.
[ -0.007413407787680626, 0.0075835310854017735, -0.0013799866428598762, 0.020055169239640236, -0.015261320397257805, -0.005607833620160818, 0.009958239272236824, -0.008765595965087414, -0.01366079319268465, 0.009715315885841846, -0.03003503382205963, 0.011888903565704823, -0.007300651632249355, 0.03639764338731766, 0.0006709899753332138, 0.012909982353448868, -0.027237702161073685, -0.01535029150545597, -0.0032673596870154142, 0.0027121808379888535, 0.0006781136617064476, -0.013341762125492096, 0.010487258434295654, -0.018008116632699966, -0.018712718039751053, 0.03325424715876579, 0.011660145595669746, -0.023776644840836525, -0.00859613437205553, 0.03274347260594368, -0.00419941172003746, 0.005052891559898853, -0.019887138158082962, -0.03640396147966385, -0.004795062821358442, 0.0011779728811234236, -0.003272745758295059, 0.02294112555682659, 0.004519338253885508, -0.0033795260824263096, 0.02320772036910057, -0.00779817346483469, 0.005087990779429674, 0.0016225769650191069, -0.011041263118386269, -0.001930169528350234, 0.000010954157914966345, -0.001277273753657937, -0.018632330000400543, 0.007805852219462395, -0.0069807725958526134, -0.005274537950754166, -0.009733683429658413, 0.004837291315197945, -0.0069625177420675755, -0.005033135414123535, 0.021030688658356667, -0.03391875699162483, 0.004351621959358454, -0.023600636050105095, -0.0052130334079265594, 0.016967477276921272, -0.015671513974666595, -0.04059623181819916, 0.005265498533844948, -0.0667492151260376, 0.011154060252010822, 0.004192733205854893, -0.011296238750219345, -0.03123614192008972, -0.010813545435667038, 0.008296928368508816, -0.00848020613193512, 0.0020609558559954166, -0.004415758885443211, -0.04067705571651459, -0.015281551517546177, -0.016347702592611313, -0.012522301636636257, 0.022046295925974846, 0.00904526375234127, -0.027561265975236893, 0.0006591072306036949, -0.002414652146399021, -0.016768738627433777, 0.006504553370177746, -0.02278577908873558, 0.028995858505368233, 0.014337358996272087, -0.000286187045276165, 0.01884835585951805, -0.007779281586408615, -0.018583370372653008, -0.0014148402260616422, -0.0014627021737396717, -0.016503525897860527, -0.018772989511489868, 0.01929572969675064, -0.00377722829580307, 0.00048302486538887024, -0.01684405654668808, 0.030172526836395264, 0.013758186250925064, 0.0018152715638279915, -0.006052916869521141, 0.01194104552268982, 0.007340388372540474, 0.009318333119153976, 0.024590451270341873, 0.008603356778621674, -0.007383377756923437, -0.021770305931568146, -0.0026060710661113262, 0.026332981884479523, 0.03516978770494461, 0.016125965863466263, 0.003716963343322277, 0.034304630011320114, 0.01260110642760992, -0.010032892227172852, -0.031720686703920364, -0.0012091086246073246, 0.0025862071197479963, 0.044128045439720154, 0.0036883591674268246, 0.03336680307984352, 0.012852768413722515, -0.010894621722400188, 0.01461472176015377, 0.007566287647932768, -0.006415211129933596, -0.005936054978519678, 0.0044742608442902565, -0.014056115411221981, 0.002115807728841901, 0.007497626822441816, -0.017358118668198586, 0.00696577737107873, 0.005423558410257101, -0.017200764268636703, 0.022316448390483856, 0.004866127856075764, 0.0022963727824389935, 0.013776705600321293, 0.015584904700517654, -0.0012804244179278612, -0.010570786893367767, 0.010868103243410587, 0.01048367004841566, 0.0074948715046048164, -0.02430812269449234, 0.007200385443866253, -0.011135488748550415, -0.014517948031425476, 0.012576274573802948, -0.009865114465355873, -0.009179344400763512, -0.017315099015831947, -0.014315968379378319, 0.0071662357077002525, -0.017428334802389145, -0.03055635467171669, 0.007191992364823818, 0.009915847331285477, 0.019066041335463524, 0.0004012039862573147, -0.026637710630893707, 0.0004357793368399143, -0.017247941344976425, 0.006466601975262165, -0.007497008889913559, -0.018115540966391563, 0.0118974968791008, 0.013904036954045296, 0.013900484889745712, 0.009913239628076553, 0.005087004974484444, 0.007117290981113911, -0.025644417852163315, 0.06644818186759949, 0.016007324680685997, -0.01585572585463524, -0.018879208713769913, -0.007458622567355633, 0.02799978293478489, -0.003953821025788784, -0.02065739408135414, -0.006712837144732475, -0.01956775411963463, 0.00457994919270277, -0.0074918232858181, -0.029400981962680817, -0.011113646440207958, 0.009611401706933975, 0.00534640159457922, 0.003153765108436346, -0.010922468267381191, 0.008517627604305744, 0.010563984513282776, 0.024007242172956467, 0.013860066421329975, 0.009385589510202408, 0.04164796322584152, -0.00600099004805088, -0.008040038868784904, -0.0012163070496171713, 0.02006102353334427, -0.016073433682322502, 0.022745423018932343, 0.019330553710460663, 0.025157777592539787, 0.0006976444274187088, 0.007326875813305378, -0.011193951591849327, 0.012467333115637302, -0.005595265422016382, -0.011345649138092995, 0.016360212117433548, -0.04077059403061867, -0.013895244337618351, 0.0005177760031074286, 0.0027186544612050056, 0.016894234344363213, 0.016044221818447113, 0.010811069048941135, -0.0039118267595767975, -0.014804881066083908, 0.01401007641106844, -0.01178665179759264, 0.0007143686525523663, -0.000043691135942935944, 0.011682417243719101, -0.012232623994350433, -0.016812670975923538, 0.04183241352438927, 0.009648995473980904, 0.012218204326927662, -0.01862514391541481, 0.015125002712011337, -0.01119766291230917, -0.008418045938014984, 0.03626526892185211, 0.04941090941429138, -0.03063000924885273, 0.014485524967312813, 0.014341726899147034, -0.004859367851167917, -0.004681117832660675, 0.025929467752575874, -0.017815884202718735, 0.007067976053804159, 0.012250542640686035, 0.015710240229964256, -0.009062189608812332, -0.025638345628976822, 0.0027791569009423256, 0.031005023047327995, -0.03270692750811577, 0.02346009947359562, -0.010865636169910431, -0.0011893846094608307, 0.0026531845796853304, -0.006005698814988136, -0.0022519538179039955, 0.016301440075039864, 0.030115192756056786, 0.026869386434555054, -0.0044381218031048775, -0.011676467955112457, -0.01951495371758938, 0.006998581811785698, -0.00139367685187608, 0.008306611329317093, -0.08073835074901581, -0.012510301545262337, -0.0073076835833489895, 0.03808010369539261, 0.008858594112098217, 0.002987670712172985, -0.006868013646453619, 0.007846508175134659, -0.00888265110552311, 0.00903964415192604, 0.040636662393808365, 0.0034629758447408676, -0.010196032002568245, -0.02221876010298729, 0.014372028410434723, -0.008312526158988476, 0.014586704783141613, 0.0289014782756567, -0.002063910011202097, -0.00365326926112175, 0.0053922454826533794, -0.039383623749017715, -0.01755661517381668, -0.007780238054692745, -0.00310541782528162, -0.006180737633258104, 0.03203129768371582, 0.0031613605096936226, -0.003826554398983717, 0.00976593792438507, 0.007988948374986649, -0.00834046769887209, -0.007533376570791006, 0.0004670247435569763, -0.03187111020088196, 0.002323827939108014, -0.0048104943707585335, -0.0032731303945183754, -0.016096465289592743, 0.0000849766656756401, -0.0035430281423032284, 0.012293746694922447, 0.023640409111976624, 0.020209800451993942, 0.009819593280553818, 0.006127762608230114, 0.02770942635834217, -0.017939534038305283, 0.0123148113489151, -0.008989314548671246, -0.0218543391674757, -0.00035153375938534737, -0.008213074877858162, 0.015638474375009537, -0.016013452783226967, 0.002617273014038801, -0.0004257112741470337, 0.01894521713256836, -0.011044306680560112, -0.011228788644075394, -0.01603427156805992, -0.030414897948503494, -0.015334704890847206, -0.006762153469026089, -0.0049332184717059135, 0.012074410915374756, 0.015701662749052048, 0.019245967268943787, -0.0008336191531270742, -0.012501499615609646, 0.006414907518774271, 0.03188309818506241, -0.017184514552354813, -0.006134022027254105, -0.002544363960623741, -0.009448397904634476, -0.016265440732240677, -0.005792647134512663, 0.019516997039318085, -0.02696528285741806, -0.019158339127898216, -0.0025967557448893785, -0.029310623183846474, -0.0030672457069158554, -0.017352744936943054, -0.00415972713381052, 0.009914565831422806, 0.044541504234075546, 0.014217991381883621, -0.014274445362389088, -0.015154710039496422, 0.014246420934796333, 0.0042212656699121, 0.005033355671912432, -0.004930844530463219, -0.006007998716086149, 0.007272558752447367, -0.004679372534155846, -0.006115559954196215, 0.008249939419329166, -0.002943703904747963, 0.015385003760457039, 0.012851901352405548, -0.010466932319104671, -0.014068234711885452, 0.01845664530992508, -0.000604547094553709, -0.0003782389685511589, 0.008314177393913269, -0.0029741607140749693, -0.0038008596748113632, 0.015630796551704407, -0.002435333328321576, 0.036678049713373184, 0.014138123020529747, -0.023444348946213722, -0.019073115661740303, 0.019426314160227776, 0.07184239476919174, -0.01854296773672104, -0.0022589711006730795, -0.005405806005001068, -0.013279296457767487, -0.027247954159975052, -0.035707101225852966, 0.026013221591711044, -0.0031943339854478836, -0.024848606437444687, 0.01207522302865982, 0.008133850991725922, 0.0040910569950938225, 0.009809755720198154, -0.03793400526046753, 0.004196901805698872, 0.003896350972354412, 0.006938360631465912, 0.005321142729371786, 0.004233549349009991, -0.006037812680006027, -0.02478501945734024, 0.005257871001958847, 0.009463989175856113, -0.015352594666182995, 0.008539139293134212, 0.005425568670034409, -0.010861100628972054, -0.010692186653614044, 0.007225742097944021, -0.023241396993398666, 0.011215917766094208, -0.004984067752957344, 0.02584686130285263, 0.0332842618227005, -0.0034715444780886173, 0.0207963939756155, -0.011840024963021278, -0.00280983978882432, -0.019666720181703568, -0.023008055984973907, -0.008963224478065968, -0.014652307145297527, 0.017787551507353783, 0.00036574481055140495, 0.02544742450118065, 0.017268899828195572, 0.00034502847120165825, -0.02142370492219925, -0.01006373856216669, -0.02250918373465538, 0.0037848306819796562, 0.008009206503629684, 0.019278893247246742, 0.015240260399878025, -0.028226468712091446, 0.010622809641063213, -0.007513853721320629, -0.03625758737325668, -0.00845428928732872, 0.0013483338989317417, -0.018843090161681175, 0.015305678360164165, -0.01590236835181713, 0.005428096279501915, -0.022103779017925262, 0.019273070618510246, -0.006007421761751175, -0.014323451556265354, -0.00974325928837061, -0.00467257434502244, -0.00992690958082676, -0.005986019968986511, -0.009274590760469437, 0.0037403027527034283, 0.015191687270998955, 0.004778043832629919, -0.013156818225979805, 0.03990015760064125, -0.003989180084317923, 0.014371177181601524, 0.0039313798770308495, -0.010115087032318115, -0.008415503427386284, -0.003145290771499276, -0.0019239457324147224, -0.01959042251110077, -0.07432861626148224, -0.005096140317618847, -0.023127220571041107, -0.005252051167190075, -0.010382594540715218, -0.015409515239298344, -0.012276783585548401, 0.002977130003273487, -0.007826413959264755, -0.003651469014585018, 0.013759216293692589, 0.0049776057712733746, -0.026943529024720192, 0.01284482330083847, 0.01271912269294262, 0.006484490819275379, -0.04541347920894623, 0.013450916856527328, -0.01753692328929901, -0.0018961136229336262, 0.0059990426525473595, -0.015891294926404953, 0.00494416244328022, 0.000557933934032917, -0.004170314408838749, -0.08066286146640778, -0.010902280919253826, -0.018671367317438126, 0.0027990778908133507, 0.003846548032015562, 0.014783037826418877, 0.009295814670622349, -0.021623654291033745, 0.0027690166607499123, -0.014266716316342354, -0.013200357556343079, 0.010384762659668922, 0.020770631730556488, -0.0010715806856751442, -0.022758182138204575, -0.005648297723382711, 0.026327090337872505, -0.03365170210599899, 0.0053099081851542, -0.018356695771217346, -0.002205329015851021, 0.020823311060667038, -0.016244685277342796, -0.00019416585564613342, -0.010979792103171349, -0.0028180787339806557, 0.0006115566939115524, 0.010173833929002285, 0.009413372725248337, 0.005266124848276377, 0.01815403252840042, -0.009259195998311043, -0.009726924821734428, -0.024441128596663475, -0.021237676963210106, -0.011161437258124352, -0.012634869664907455, 0.023556824773550034, -0.006345322821289301, -0.009384354576468468, -0.0015112723922356963, 0.007225692737847567, 0.020774420350790024, 0.010842927731573582, -0.01031471136957407, 0.009701589122414589, 0.006122680846601725, -0.0026494842022657394, 0.007961908355355263, 0.02281082794070244, 0.0016953572630882263, -0.012476438656449318, 0.02072783000767231, 0.0010371298994868994, -0.033559560775756836, 0.00522240437567234, -0.001865800004452467, 0.02196202240884304, 0.05637660622596741, 0.0030518495477735996, -0.011170141398906708, 0.00483888853341341, -0.014677638188004494, 0.07162067294120789, -0.013925421983003616, -0.0018464368768036366, -0.024264154955744743, -0.009283041581511497, 0.007243468426167965, -0.0044045052491128445, -0.011888574808835983, 0.020044203847646713, -0.019056834280490875, 0.012010762467980385, 0.000293683260679245, 0.009809110313653946, 0.012004640884697437, 0.016632061451673508, 0.024617139250040054, -0.008640080690383911, 0.01775541715323925, 0.007370462641119957, 0.010174084454774857, -0.010392505675554276, 0.016134852543473244, -0.011959933675825596, -0.0032770978286862373, 0.006399783305823803, -0.0053653656505048275, -0.015016872435808182, 0.006939217913895845, -0.021008778363466263, -0.012752290815114975, -0.020547568798065186, 0.002805044176056981, -0.0037956074811518192, 0.0030320128425955772, 0.03142969682812691, 0.023485485464334488, -0.006828117184340954, 0.001426289090886712, -0.014104139059782028, 0.00021227821707725525, -0.001434245496056974, 0.008725319057703018, 0.010469915345311165, 0.003877796931192279, 0.011992637068033218, 0.02864174172282219, 0.030781684443354607, -0.011095894500613213, 0.01809736341238022, 0.009957519359886646, -0.008472203277051449, 0.003351530758664012, -0.01711028814315796, -0.0033250339329242706, 0.018444020301103592, -0.011340752243995667, 0.008996499702334404, 0.014185190200805664, -0.020936600863933563, -0.029877495020627975, -0.001494008582085371, -0.026664286851882935, -0.05027783662080765, -0.010530123487114906, 0.00015479233115911484, 0.028324367478489876, 0.020018156617879868, -0.021507980301976204, 0.0011378610506653786, 0.012484071776270866, -0.014506103470921516, -0.0003769288305193186, 0.005575193092226982, 0.013241201639175415, 0.012355386279523373, 0.008572537451982498, 0.01597452536225319, -0.002699062693864107, 0.0216490738093853, 0.0009454893879592419, -0.014455665834248066, 0.024637948721647263, 0.030441954731941223, -0.016347937285900116, 0.013162491843104362, 0.019976899027824402, -0.02025272697210312, 0.012078255414962769, -0.0041852486319839954, 0.009318839758634567, 0.0005467263981699944, -0.0013108989223837852, 0.0053335833363235, -0.01769491657614708, 0.008939005434513092, 0.03391527011990547, -0.0012204903177917004, 0.007817653939127922, 0.005782539024949074, 0.015776120126247406, 0.0027754642069339752, -0.015409412793815136, -0.014858531765639782, 0.001970822922885418, -0.015840673819184303, -0.006132091395556927, 0.0363188162446022, 0.025281906127929688, 0.006463981233537197, 0.02541501820087433, 0.0011971290223300457, 0.003933040890842676, 0.03763782978057861, -0.003933541476726532, 0.005769191775470972, 0.029155854135751724, -0.026010597124695778, 0.004078692756593227, 0.0036517377011477947, -0.009977295063436031, 0.009319944307208061, -0.01077270694077015, -0.021184321492910385, 0.019607406109571457, 0.008448680862784386, -0.03453920781612396, -0.013663512654602528, 0.013548682443797588, 0.011867647990584373, -0.028084732592105865, 0.010189719498157501, -0.030227508395910263, 0.026263145729899406, 0.01955738477408886, 0.004361552186310291, -0.005740259308367968, -0.000775500840973109, 0.011827753856778145, 0.0011309096589684486, 0.03746991977095604, -0.006372234784066677, -0.015647659078240395, -0.003916749730706215, 0.015482267364859581, 0.00936473160982132, -0.016933143138885498, 0.0093862134963274, -0.016379859298467636, 0.009548678994178772, -0.007714498788118362, -0.005390092730522156, -0.0014801181387156248, 0.01901402324438095, -0.009499089792370796, -0.00945528969168663, 0.013245325535535812, -0.0012874482199549675, -0.016745340079069138, -0.020911522209644318, -0.004274572245776653, -0.01767420955002308, -0.016737427562475204, -0.00018709339201450348, 0.013746460899710655, 0.009146653115749359, 0.004209289327263832, 0.0015385644510388374, 0.028170067816972733, 0.0006022423040121794, 0.023162320256233215, 0.016110461205244064, 0.01819813810288906, -0.02182699367403984, 0.022074047476053238, -0.005289013031870127, -0.015462388284504414, -0.016881845891475677, 0.0051279873587191105, 0.016325172036886215, 0.01321922242641449, 0.004886916372925043, -0.039850782603025436, -0.007392398547381163, -0.0034502665512263775, -0.020879041403532028, 0.002247362397611141, -0.010325951501727104, 0.004166742786765099, -0.0016649146564304829, 0.024654284119606018, -0.004076946992427111, -0.04041445255279541, 0.004398292861878872, -0.007061559706926346, -0.01728484407067299, 0.01168323028832674, 0.007641872391104698, -0.03591213375329971, 0.016078077256679535, -0.002575298771262169, 0.00879209116101265, 0.0014119381085038185 ]
[ 0.11748984456062317, -0.1967707872390747, -0.38696008920669556, 0.24759912490844727, 0.2121344804763794, 0.09431935101747513, 0.21582503616809845, 0.10381120443344116, -0.01528378389775753, -0.47150737047195435, 0.1556597352027893, 0.08255122601985931, -0.4805924594402313, 0.4958494007587433, -0.18648837506771088, 0.5106714367866516, -0.13613469898700714, 0.13284073770046234, -0.35609138011932373, -0.29062190651893616, -0.011399899609386921, -0.21943414211273193, 0.6550502181053162, -0.15977053344249725, -0.06702006608247757, -0.3150790333747864, 0.2822810113430023, -0.05382176488637924, 0.2794610559940338, -0.29036232829093933, -0.1775103211402893, 0.23338133096694946, -0.15547926723957062, -0.13709519803524017, -0.1118154302239418, -0.37475335597991943, -0.421383798122406, -0.20145124197006226, -0.37029457092285156, -0.197798952460289, -0.3109130561351776, -0.16712123155593872, 0.21566353738307953, -0.14073646068572998, -0.07120081782341003, -0.17859026789665222, -0.9405254125595093, 0.5695997476577759, -0.3024469017982483, -0.042617663741111755, 0.08777762204408646, 0.157301127910614, 0.1190079003572464, 0.7905386686325073, 0.37523841857910156, -0.02881651744246483, -0.6528142094612122, -0.4776948392391205, 0.13811379671096802, -0.6091762185096741, 0.02307015284895897, 0.13863731920719147, -0.5729179382324219, 0.3268938362598419, 0.5288616418838501, 1.0917872190475464, 0.1756458580493927, -0.047286830842494965, -0.7751834988594055, 0.1721227467060089, -0.13386858999729156, -0.470334529876709, -0.07378581166267395, 0.5222612619400024, -0.24169836938381195, -0.297730416059494, -0.35338345170021057, -0.39157673716545105, 0.2511409521102905, 0.11540389806032181, 0.04108906537294388, 0.21256694197654724, 0.32234933972358704, -0.061302464455366135, 0.553127646446228, -0.12100211530923843, -0.12199722975492477, 0.7250934839248657, -0.8129326701164246, -0.2756636142730713, -0.12745214998722076, 0.014160031452775002, 0.7110378742218018, 0.48567432165145874, 0.26922035217285156, 0.4495232403278351, 0.2900238037109375, -0.08781539648771286, -0.07777909934520721, 0.4587334990501404, -0.3491687774658203, 0.5643133521080017, 0.26541823148727417, -0.42195484042167664, -0.23422347009181976, -0.35474950075149536, -0.07963155210018158, -0.2813459634780884, 0.1059584841132164, 0.1617925763130188, -1.0382859706878662, 0.21022085845470428, -0.23769545555114746, -0.2861366868019104, -0.7369381785392761, 0.2850763499736786, -0.01266869343817234, -0.22242259979248047, 0.47874021530151367, 0.14472880959510803, -0.19847457110881805, 1.155029058456421, -0.13020272552967072, 0.5324447751045227, -0.058132290840148926, -0.3931709825992584, 0.10982625186443329, -0.32454684376716614, -0.14546771347522736, 0.8682851791381836, 0.19892056286334991, 0.8241428732872009, -0.36031341552734375, 0.4079867899417877, 0.5566710233688354, -0.03168727457523346, 0.0858592763543129, 0.0511774979531765, 0.7534759044647217, 0.32134121656417847, -0.37671682238578796, -0.24221119284629822, 0.21536576747894287, 0.3045184016227722, 0.004259972833096981, -0.47268354892730713, -0.4109652042388916, -0.05948704481124878, 0.022553181275725365, -0.3865657448768616, -0.12735070288181305, -0.3549244999885559, -0.5498647689819336, -0.6497879028320312, 0.0472831055521965, 0.08603278547525406, 0.044588420540094376, -0.1557489037513733, 0.1130034402012825, 0.1032198816537857, -0.10841961950063705, 0.12207901477813721, -0.1401292383670807, 0.17525456845760345, 0.36285194754600525, -0.05251771956682205, 0.4677302837371826, 0.4371330440044403, -0.017754413187503815, -0.3436207175254822, -0.3755350410938263, -0.02588980458676815, 0.5187067985534668, -0.7596088647842407, 0.020182020962238312, 0.10242701321840286, 0.39937272667884827, -0.19718052446842194, 0.04708711802959442, 0.13256067037582397, -0.6370640993118286, -0.0043885959312319756, -0.2832334637641907, -0.22686567902565002, 0.1624535322189331, -0.3644522428512573, 0.6438122391700745, -0.13863736391067505, -0.590742290019989, 0.30792710185050964, -0.24375946819782257, -0.11855626851320267, 0.8809911608695984, -0.6545602679252625, 1.1269868612289429, -0.15222977101802826, -0.7428427338600159, 1.064051628112793, -0.10333177447319031, -0.001739113125950098, -0.4070051610469818, -0.06763528287410736, 0.19389402866363525, -0.14334659278392792, -0.45833587646484375, 0.09498915821313858, -0.023796165362000465, 0.10859084874391556, 0.26119187474250793, 0.10291022062301636, -0.1731603741645813, -0.44396525621414185, 0.10065130144357681, -0.035985108464956284, 0.3416331708431244, -0.5368324518203735, -0.4211249053478241, -0.2409493625164032, -0.15485042333602905, -0.5542076230049133, 0.6713470816612244, -0.7810864448547363, 0.3923749327659607, 0.7257910370826721, 0.31392374634742737, 0.45071345567703247, 0.7328343987464905, 0.11462219804525375, 0.5963858962059021, -0.3728872835636139, 0.20464229583740234, -0.28058427572250366, 0.4625585973262787, -0.5284184813499451, 0.6252616047859192, 0.6204338073730469, 0.02474450320005417, -0.25542154908180237, -0.018470745533704758, -0.09583164751529694, -0.14317095279693604, 0.4392063319683075, -0.41181081533432007, 0.01902507245540619, -0.008925785310566425, -0.36778947710990906, -0.20378947257995605, 0.18213927745819092, -1.3321763277053833, 0.4119027554988861, -0.1454373598098755, 0.10526904463768005, 0.25590020418167114, -0.9089311957359314, 0.053492747247219086, 0.1628357470035553, -0.01476246677339077, -0.38754692673683167, 0.06820832192897797, -0.3672274053096771, -0.42038285732269287, -0.09290782362222672, 0.09347911179065704, 0.17769907414913177, -0.2814314067363739, -0.15921136736869812, -0.3405425250530243, -0.12817764282226562, 1.0894004106521606, 0.5408754944801331, 1.095893383026123, -0.3820628523826599, -0.8174732327461243, -0.1163138896226883, -0.30511876940727234, -0.4463845491409302, -0.6117915511131287, 0.29416200518608093, -0.1814442127943039, 0.10538750141859055, -0.11934049427509308, 0.4496711194515228, 0.4815824031829834, -0.40514707565307617, -0.2584972083568573, 0.07220231741666794, 0.17288938164710999, -0.19796434044837952, -0.20795167982578278, -0.3175828754901886, -0.5972768664360046, 0.13518205285072327, -0.43143001198768616, 0.013524447567760944, 0.41110438108444214, -0.03623320907354355, -0.03956377133727074, -0.05828959867358208, 0.823097288608551, -0.1111629456281662, -0.42208969593048096, -0.03140115365386009, -0.338681697845459, -0.022994566708803177, 0.1111801341176033, -0.0778822973370552, -0.1595715582370758, 0.37479037046432495, -5.883775234222412, -0.036109648644924164, -0.17802530527114868, -0.3058095872402191, 0.14940714836120605, 0.013083329424262047, 0.9351543188095093, -0.31333255767822266, -0.26985812187194824, 0.38183799386024475, 0.2805629074573517, 0.3196413218975067, 0.1356029510498047, 0.38176265358924866, -0.2610941529273987, -0.07697930932044983, -0.450181245803833, -0.2899627387523651, 0.6496737599372864, 0.24357907474040985, -0.11389574408531189, -0.40801331400871277, 0.21329574286937714, 0.21580828726291656, -0.0623893216252327, -0.028798334300518036, -0.5344893336296082, -0.2506532371044159, -0.12104367464780807, -0.4922286868095398, -0.005035041365772486, -0.9910818338394165, 0.1170201450586319, -0.16312852501869202, 0.2462371289730072, -0.15917043387889862, 0.10434377193450928, 0.2080114185810089, -0.0446295328438282, -0.018909649923443794, 0.41374149918556213, 0.36443427205085754, 0.04086863994598389, -0.1010124534368515, 0.07018090039491653, 0.11202871799468994, 0.21983300149440765, 0.4238935708999634, -0.285763680934906, 1.0185420513153076, 0.5191934704780579, 0.16756196320056915, 0.6642287969589233, 0.48204371333122253, 0.4911904036998749, 0.05957941710948944, 0.04779591038823128, -0.6337626576423645, -0.34103551506996155, -0.03480594977736473, -0.08449658751487732, -0.29132822155952454, -0.2714226543903351, -0.7891916036605835, 0.2609865665435791, 0.026272544637322426, -0.5472490787506104, -0.152444988489151, 0.5664036273956299, -0.17423878610134125, -0.040484603494405746, -0.6622586250305176, 0.5574565529823303, -0.7110564112663269, 0.7527744770050049, 0.06361955404281616, 0.4572616219520569, -0.03348574414849281, -0.054042998701334, 0.012595849111676216, -0.1382662057876587, -0.0542924739420414, 0.03263378143310547, -0.3058546781539917, 0.28923606872558594, -0.3467619717121124, -0.2266460657119751, 0.4625539779663086, 0.018425466492772102, 0.4253171682357788, 0.4514981210231781, 0.01601065881550312, 0.2710533142089844, 0.06583157181739807, 0.5092456340789795, 0.6560413837432861, 0.02579468861222267, 0.561406672000885, 0.650755763053894, 0.03350241482257843, 0.21119043231010437, 0.13301660120487213, -0.3641018569469452, -0.5102275013923645, -0.30201900005340576, 0.21988545358181, -0.07050114870071411, -0.00015893319505266845, -0.011151590384542942, -0.8458966612815857, 0.02536110021173954, 0.26996228098869324, -0.5332571268081665, -0.4123302400112152, 0.4154241979122162, -0.2809164524078369, -0.6230456829071045, 0.32938992977142334, 0.8284277319908142, -0.37915852665901184, -0.08184485137462616, 0.3349016010761261, -0.9558789730072021, 0.6632208824157715, 0.07498114556074142, 0.1238262951374054, 0.05626261979341507, 0.9907253980636597, -0.5463749170303345, -0.4947681427001953, 0.06691212952136993, 0.4000990390777588, -0.42392757534980774, -0.18384280800819397, -0.0027127587236464024, -0.11822610348463058, -0.3409598171710968, 0.3697194755077362, 0.2876194417476654, -0.1596432626247406, 0.6693368554115295, -0.3026888966560364, 0.22017015516757965, 0.04572374373674393, 0.39493727684020996, 0.156537726521492, -0.005945300683379173, -0.2339455783367157, -0.09073386341333389, -0.26269716024398804, 0.1279691606760025, -0.21595875918865204, 0.2657904028892517, 0.10028953850269318, -0.4132642149925232, 0.3849889934062958, 0.25533896684646606, 0.21521908044815063, 0.1616729199886322, -0.5067495703697205, -0.11140299588441849, 0.1509077548980713, -0.8251105546951294, -0.28647178411483765, -0.4116881191730499, 0.28153249621391296, -0.1144026592373848, -0.5092442631721497, -0.29847365617752075, 0.12294887006282806, -0.6047769784927368, -0.1606884002685547, 0.46988415718078613, -0.23918063938617706, 0.1535469889640808, -0.3755488991737366, -0.01988404616713524, -0.15657365322113037, -0.40752434730529785, -0.30540183186531067, 0.06510387361049652, 0.023847132921218872, 0.0900125503540039, 0.45192569494247437, 0.21426452696323395, -0.13079556822776794, -0.2513567805290222, 0.05277182161808014, -0.43762367963790894, -0.43855398893356323, 0.16736000776290894, 0.1677631288766861, 0.4716019928455353, -0.30840474367141724, 0.000810550875030458, 0.28120896220207214, 0.12117228657007217, -0.014813018962740898, -0.08054543286561966, -0.5914285778999329, 0.34557655453681946, -0.25450968742370605, 0.12398161739110947, 0.37847229838371277, 0.5461558699607849, 0.10872843861579895, 0.11008698493242264, -0.07967207580804825, -0.2556453347206116, -0.2519635558128357, -0.3463149666786194, -0.669625461101532, -0.15932436287403107, 0.5318255424499512, 0.058421291410923004, -0.24297209084033966, 0.47163277864456177, -0.3880957365036011, -0.1926194280385971, 0.5677671432495117, 0.7848556041717529, 0.15310971438884735, 0.2775546610355377, 0.044723283499479294, -0.8288881778717041, 0.24669376015663147, 0.2270386964082718, -0.6481609344482422, 0.7969693541526794, 0.0478733628988266, -0.12707500159740448, -0.18019409477710724, -0.4738248586654663, -0.1763598471879959, -0.4682174324989319, -0.7743785381317139, -0.2613397538661957, -0.09652683138847351, -0.3199203908443451, 0.10427729785442352, 0.10432212054729462, 0.21675173938274384, -0.07313612103462219, 0.242391437292099, -0.20973174273967743, 0.3253314197063446, 0.2714998722076416, -0.4322734475135803, -0.6014198064804077, 0.31228405237197876, 0.31973183155059814, -0.1855621188879013, -0.13329432904720306, 0.33250629901885986, 0.8332156538963318, 0.3892727196216583, -0.07222054898738861, -0.2680940330028534, -0.06297875195741653, 0.07955808192491531, -0.5277767181396484, -0.1662282645702362, 0.21092231571674347, 0.18806706368923187, 0.06436124444007874, -0.1887076199054718, 0.3406231999397278, -0.351978063583374, 0.2794140577316284, -0.36265355348587036, 0.1267908662557602, -0.005261662416160107, 0.7995973825454712, 0.0795099288225174, 0.2568538784980774, 0.31331127882003784, -0.21523796021938324, 0.07087109237909317, 0.19598020613193512, 0.20821711421012878, -0.024465348571538925, -0.719710648059845, -0.16435161232948303, -0.6882823705673218, 0.5345845222473145, -0.41189858317375183, 0.8059602379798889, -0.8406791687011719, 0.05383288487792015, 0.17962442338466644, -0.11807046830654144, -0.049652863293886185, -0.03113373927772045, -0.4095402956008911, 0.07018276304006577, -0.21717621386051178, -0.06391437351703644, 0.2838965356349945, -0.06885676831007004, -0.14010071754455566, -0.4382033944129944, 0.35971784591674805, 0.44942769408226013, -0.41548559069633484, -0.3100999891757965, 0.04255201295018196, 0.022569216787815094, -0.2713764011859894, -0.5851972699165344, 0.05264132097363472, 0.07628240436315536, 0.24122275412082672, -0.007389312610030174, 0.0011495106155052781, 0.007551422342658043, 0.17624086141586304, 0.07090995460748672, -0.26087507605552673, 0.5035804510116577, 0.1488974392414093, 0.13696900010108948, 0.4886716902256012, 0.4283333718776703, -0.6925987601280212, -0.11947310715913773, 0.15407656133174896, 0.3491427004337311, 0.3363153040409088, -0.6416850090026855, 0.5516695380210876, 0.7325451970100403, 0.14404936134815216, -0.239615797996521, 0.5377458930015564, 0.38833755254745483, 0.1134958490729332, -0.4376329779624939, -0.44451165199279785, -0.007571698632091284, 0.08863894641399384, 0.9121001362800598, 0.7937549352645874, 0.020568227395415306, 0.14530175924301147, 0.5714612007141113, 0.30029216408729553, 0.19804149866104126, 0.23849035799503326, -0.22900262475013733, 0.2679062783718109, 0.3639290928840637, -0.5510329604148865, -0.3365441858768463, -0.19475220143795013, -0.5777956247329712, 0.28079643845558167, 0.4885041415691376, -0.06138293817639351, -0.08316610008478165, 0.226737841963768, -0.5619447231292725, 0.676741898059845, -0.4078666567802429, 0.41993221640586853, 0.09289777278900146, -0.3608910143375397, 0.37243467569351196, -0.11390560865402222, 0.16127118468284607, 0.07938597351312637, 0.5680540204048157, 0.10905463993549347, -0.2215108424425125, -0.14277954399585724, 0.1450325846672058, -0.40203842520713806, 0.18958397209644318, 0.222699373960495, -0.10153621435165405, 0.19126427173614502, -0.415122389793396, -0.006203340366482735, -0.38920101523399353, -0.36114293336868286, -0.0374540351331234, -0.25419557094573975, -0.172414168715477, -0.12487135827541351, 0.2844313085079193, 0.12999467551708221, 0.24063469469547272, -0.4326880872249603, 0.592354416847229, 0.17030537128448486, 0.1155160516500473, -0.2228703647851944, 0.05738150328397751, 0.008588594384491444, 0.6772081255912781, 0.17606468498706818, 0.5186687111854553, 0.2912234961986542, -0.24549974501132965, -0.09090806543827057, -1.0414241552352905, 0.8901216983795166, 0.0012411962961778045, -0.5968641638755798, -0.722908079624176, -0.06422003358602524, 1.302077054977417, 0.6078442335128784, -0.45166516304016113, 0.3329940140247345, 0.05619259551167488, 0.31994637846946716, 0.30675390362739563, -0.535811722278595, -0.1792745739221573, -0.6454117298126221, 0.10218972712755203, -0.6531303524971008, 0.41204240918159485, -0.3109087646007538, -0.28539514541625977, -0.08532165735960007, 0.8519254922866821, 0.1192668229341507, -0.12632891535758972, 0.7310145497322083, -0.38954290747642517, 0.20344135165214539, -0.3197553753852844, 0.3559960126876831, -0.43240147829055786, 0.15157166123390198, -0.500069260597229, 0.17307749390602112, 0.18415877223014832, -0.47408169507980347, 0.15562543272972107, 0.3144506812095642, -0.14424172043800354, -0.439227819442749, 0.34662309288978577, 0.12525109946727753, -0.49480995535850525, -0.2944989502429962, -0.46874287724494934, 0.07368215918540955, 0.27292031049728394, -0.32130300998687744, -0.36522141098976135, 0.25886356830596924, 0.1739160418510437, -0.5214117169380188, -0.2507469952106476, -0.4085504412651062, -0.1082247793674469, -0.10783088207244873 ]
Upon activation, neutrophils release DNA fibers decorated with antimicrobial proteins, forming neutrophil extracellular traps (NETs). Although NETs are bactericidal and contribute to innate host defense, excessive NET formation has been linked to the pathogenesis of autoinflammatory diseases. However, the mechanisms regulating NET formation, particularly during chronic inflammation, are poorly understood. Here we show that the G protein–coupled receptor (GPCR) CXCR2 mediates NET formation. Downstream analyses showed that CXCR2-mediated NET formation was independent of NADPH oxidase and involved Src family kinases. We show the pathophysiological relevance of this mechanism in cystic fibrosis lung disease, characterized by chronic neutrophilic inflammation. We found abundant NETs in airway fluids of individuals with cystic fibrosis and mouse cystic fibrosis lung disease, and NET amounts correlated with impaired obstructive lung function. Pulmonary blockade of CXCR2 by intra-airway delivery of small-molecule antagonists inhibited NET formation and improved lung function in vivo without affecting neutrophil recruitment, proteolytic activity or antibacterial host defense. These studies establish CXCR2 as a receptor mediating NADPH oxidase–independent NET formation and provide evidence that this GPCR pathway is operative and druggable in cystic fibrosis lung disease.
[ -0.015107719227671623, 0.012173820286989212, -0.008659547194838524, 0.017549797892570496, 0.010255914181470871, -0.013798975385725498, 0.009848745539784431, -0.00568549707531929, -0.01143743097782135, -0.007123506627976894, -0.0019049415132030845, 0.010473500937223434, -0.006101876497268677, 0.0059597669169306755, -0.004129988607019186, 0.016458742320537567, 0.0013894332805648446, 0.011613357812166214, 0.007061733398586512, -0.010717224329710007, -0.008009362034499645, -0.007775539066642523, 0.010493932291865349, -0.026072261855006218, -0.002457608701661229, 0.009269557893276215, -0.00026354147121310234, -0.005621559917926788, -0.010933456011116505, -0.005046119913458824, -0.014941957779228687, 0.011403506621718407, 0.028758814558386803, 0.015010345727205276, -0.004176509100943804, 0.009104844182729721, -0.0018630493432283401, 0.022651471197605133, 0.028559546917676926, -0.004259765148162842, 0.010392456315457821, -0.010365541093051434, 0.00494538014754653, -0.015898600220680237, -0.007142112590372562, -0.024569250643253326, 0.0014053091872483492, 0.016273258253932, -0.020026199519634247, 0.0071601239033043385, -0.014125100336968899, -0.001949029741808772, -0.01157987117767334, 0.004963311832398176, -0.005957932211458683, 0.036721121519804, 0.01790039986371994, -0.0035452423617243767, 0.010539345443248749, -0.007486153393983841, 0.002440051408484578, -0.01956717111170292, 0.03382330387830734, 0.004152377136051655, 0.017659850418567657, -0.06679335236549377, 0.04097326099872589, 0.01061766967177391, 0.0013767810305580497, 0.033493269234895706, -0.0013601133832708001, 0.008195415139198303, -0.020493293181061745, 0.00489558232948184, 0.01278273481875658, -0.012510983273386955, -0.006220677401870489, 0.012347282841801643, 0.009301639162003994, 0.031931109726428986, -0.010705903172492981, -0.01830108091235161, 0.005405858624726534, 0.01983153447508812, 0.02518443763256073, 0.014421996660530567, -0.01585530675947666, 0.0009664928074926138, 0.0030556200072169304, 0.02307939901947975, 0.006607483606785536, 0.01220877468585968, -0.043426111340522766, 0.014647223986685276, -0.0050201755948364735, -0.00542052835226059, 0.0006063701584935188, 0.02393951267004013, 0.01401185616850853, 0.015199065208435059, -0.018592657521367073, 0.0016651228070259094, 0.017738332971930504, 0.008339573629200459, 0.008758427575230598, 0.006847398355603218, 0.01059336680918932, 0.01246207021176815, 0.02527680993080139, 0.012061091139912605, 0.007569997571408749, 0.004854660481214523, -0.012527698650956154, 0.010092701762914658, -0.001766030676662922, 0.010441547259688377, -0.005770436488091946, -0.01989801786839962, 0.014902524650096893, 0.0005841935053467751, 0.003649431746453047, -0.036696188151836395, -0.0036817830987274647, -0.006836447864770889, 0.007358805276453495, 0.002468674210831523, -0.004608099814504385, 0.004340033046901226, 0.016731921583414078, 0.006596304476261139, -0.006594729144126177, 0.006990391295403242, -0.004845535382628441, 0.027889616787433624, 0.0019292356446385384, -0.00405824976041913, -0.011620492674410343, 0.0005261258338578045, 0.011132365092635155, -0.03134407848119736, -0.0027171990368515253, 0.009543965570628643, 0.0013819788582623005, 0.007479500025510788, 0.014461450278759003, 0.020139135420322418, -0.001010100357234478, -0.003030653577297926, 0.022693829610943794, -0.01098637469112873, -0.012105087749660015, -0.020429767668247223, 0.01145988143980503, -0.0019940738566219807, 0.04304208606481552, 0.028205543756484985, -0.015352275222539902, -0.017525946721434593, -0.005338456481695175, 0.0013088386040180922, 0.009246915578842163, -0.016388269141316414, 0.03426099568605423, 0.009308241307735443, -0.0009483657777309418, 0.012276940047740936, 0.010588278993964195, 0.0016330827493220568, -0.014085515402257442, 0.006529942154884338, -0.0024739440996199846, -0.026922037824988365, -0.008916104212403297, 0.013179212808609009, -0.00996625330299139, -0.0018869219347834587, 0.025433000177145004, 0.004841137211769819, -0.006618025712668896, 0.06685073673725128, 0.014024137519299984, 0.0015548944938927889, 0.032386813312768936, 0.0012917304411530495, 0.006623163819313049, -0.01632526144385338, 0.04774225503206253, -0.0125663373619318, 0.0004918256308883429, -0.003156446386128664, 0.008007954806089401, 0.016626596450805664, -0.008452813141047955, -0.010924209840595722, -0.015492557547986507, 0.002846767660230398, 0.030751455575227737, -0.0026539000682532787, 0.010236935690045357, 0.010778862982988358, -0.03577534481883049, -0.008555020205676556, 0.03150396794080734, -0.024042371660470963, -0.016860079020261765, 0.0016423577908426523, 0.01546928845345974, 0.029858820140361786, -0.005647189915180206, 0.0011001424863934517, 0.011342030949890614, -0.007229869719594717, -0.007194997742772102, -0.011320563964545727, 0.01496000587940216, 0.0030217720195651054, -0.01667810045182705, -0.0022474161814898252, -0.0009068758226931095, -0.013320889323949814, -0.0021415618248283863, 0.009072931483387947, 0.001941450871527195, -0.026272905990481377, 0.011811038479208946, 0.0031050730030983686, 0.007680060341954231, 0.010474590584635735, 0.0015509184449911118, 0.005342877935618162, 0.0010484890080988407, -0.008258640766143799, -0.011653589084744453, 0.02147480472922325, -0.012024389579892159, 0.01529176440089941, 0.012525965459644794, -0.020649543032050133, 0.009806704707443714, -0.010929767973721027, -0.0021953838877379894, -0.01963590830564499, 0.025178320705890656, -0.008018754422664642, 0.006607235874980688, -0.006833745166659355, 0.015517149120569229, -0.0038988899905234575, -0.01091470941901207, -0.011692628264427185, 0.009004784747958183, -0.011269208043813705, 0.0064994036220014095, -0.037729114294052124, -0.009941603057086468, -0.04481268674135208, 0.03111879900097847, -0.012919239699840546, 0.025797240436077118, 0.00803647842258215, 0.002672628266736865, 0.004009987227618694, 0.007206721697002649, 0.022036103531718254, -0.03180859982967377, 0.035732854157686234, -0.008081678301095963, -0.004481184761971235, 0.002016468206420541, 0.015089675784111023, 0.005544363521039486, -0.004620679188519716, 0.0015805563889443874, -0.08158305287361145, -0.007961522787809372, -0.011115852743387222, -0.02720610238611698, 0.007063098717480898, -0.014270083978772163, 0.0007057418115437031, 0.014894997701048851, -0.01587032340466976, -0.010552296414971352, -0.015758246183395386, 0.023251451551914215, -0.004540633410215378, 0.004515437874943018, 0.038149528205394745, -0.001519774436019361, 0.012174289673566818, 0.00011070491746068001, -0.004348509479314089, -0.034847185015678406, 0.009872541762888432, -0.03369991481304169, 0.0020140688866376877, -0.0021543893963098526, -0.013674459420144558, 0.0315219983458519, 0.014544572681188583, 0.01146392896771431, -0.030944354832172394, 0.016064705327153206, -0.004809635225683451, -0.017138393595814705, 0.004336783662438393, 0.0008855373598635197, 0.032688483595848083, -0.000510739628225565, -0.018289964646100998, -0.011164494790136814, -0.01153968833386898, 0.007020683493465185, -0.004922104068100452, 0.021908264607191086, -0.004503699950873852, 0.01739807054400444, 0.023766951635479927, 0.010510755702853203, 0.023703284561634064, -0.0031445426866412163, 0.010427996516227722, 0.005723963025957346, 0.01145543809980154, -0.0020833457820117474, -0.010952228680253029, 0.013131434097886086, -0.00016820209566503763, 0.009943497367203236, -0.02422722615301609, 0.025161530822515488, -0.010505203157663345, -0.0012487703934311867, 0.001468781614676118, 0.011933624744415283, 0.010903658345341682, -0.0007942123338580132, -0.010316215455532074, -0.003181473584845662, 0.022714613005518913, 0.013484783470630646, -0.013108115643262863, 0.017507847398519516, -0.010736104100942612, 0.012894464656710625, -0.0018823561258614063, -0.007428477518260479, -0.015953684225678444, -0.01231208723038435, -0.010973643511533737, -0.015682589262723923, -0.03552284836769104, -0.009203416295349598, -0.008092666044831276, 0.0002188272774219513, -0.021979089826345444, -0.015911154448986053, -0.009284066036343575, -0.016406476497650146, 0.001967131160199642, 0.03986239805817604, 0.011318512260913849, -0.013411665335297585, 0.016094621270895004, -0.000292336568236351, 0.008165376260876656, 0.007785698398947716, -0.0033438866958022118, -0.009765105322003365, -0.003988794982433319, -0.005098926834762096, 0.002869407180696726, 0.009685717523097992, -0.039893485605716705, 0.002568557858467102, 0.011996789835393429, -0.007385155186057091, 0.016875743865966797, 0.008925517089664936, 0.007825274020433426, 0.007685923483222723, -0.006090451497584581, 0.0013425928773358464, -0.0082557937130332, -0.012229056097567081, -0.00663373339921236, 0.02210785076022148, 0.01033357810229063, 0.025318387895822525, -0.000709964893758297, -0.018465155735611916, 0.07247226685285568, 0.00001731771044433117, -0.005061154253780842, 0.0037799121346324682, 0.009019631892442703, -0.02143687754869461, -0.02121409773826599, 0.006202703341841698, -0.02446514554321766, 0.004578705411404371, 0.012838592752814293, -0.016266969963908195, -0.01793120801448822, 0.008197400718927383, -0.02018161118030548, -0.000886022113263607, -0.002832770347595215, 0.017549941316246986, 0.01563982665538788, -0.009080193936824799, -0.016889413818717003, -0.021117035299539566, -0.006782951299101114, 0.0061057694256305695, 0.0009584808722138405, -0.02809211239218712, 0.0075731435790658, -0.010187546722590923, -0.0019741335418075323, 0.006894456222653389, -0.010949036106467247, -0.002314251847565174, -0.006417871452867985, -0.0011779200285673141, 0.0187393631786108, -0.00013917393516749144, 0.024364760145545006, -0.023599330335855484, -0.011851386167109013, 0.007143552880734205, -0.026126857846975327, -0.012503175064921379, 0.04555065929889679, 0.017232457175850868, -0.03070165403187275, 0.027666058391332626, 0.0205395445227623, -0.004572708159685135, -0.006204534787684679, -0.012316619977355003, -0.009152352809906006, 0.014745546504855156, 0.007754229009151459, 0.0023198695853352547, -0.0035709375515580177, -0.030202636495232582, 0.03126563876867294, -0.009437799453735352, 0.021374182775616646, -0.014166740700602531, -0.01648414134979248, 0.008886300958693027, 0.011326104402542114, -0.00658114068210125, -0.0035671063233166933, 0.0003016483969986439, 0.0066603198647499084, -0.0017303039785474539, -0.019153043627738953, 0.007228865288197994, 0.006977313198149204, -0.004259477369487286, -0.011547964997589588, 0.0015501934103667736, -0.02559834159910679, -0.020248301327228546, 0.008041724562644958, -0.015439041890203953, 0.02070654183626175, -0.007436321582645178, 0.012654472142457962, 0.03502786159515381, 0.013915524818003178, -0.011212125420570374, 0.014309793710708618, 0.002425053622573614, -0.023362819105386734, -0.07540486007928848, 0.014310979284346104, -0.006075574085116386, -0.003375799860805273, 0.011779725551605225, 0.012662498280405998, -0.011359418742358685, 0.005622431170195341, -0.006627659313380718, 0.0003867871128022671, -0.015844468027353287, -0.012143313884735107, 0.027353623881936073, -0.0004648026078939438, 0.010884392075240612, 0.011781174689531326, 0.0040982868522405624, 0.0015780540416017175, -0.0073234811425209045, -0.005947318859398365, 0.010034680366516113, -0.013080625794827938, -0.031219305470585823, 0.01695931702852249, -0.0012128932867199183, -0.0813150405883789, -0.000140500720590353, 0.018105972558259964, 0.004873890429735184, -0.0005724201910197735, -0.016500694677233696, 0.01704791560769081, -0.02084922417998314, 0.019699005410075188, -0.0164400115609169, -0.008513297885656357, 0.018818916752934456, -0.01960606686770916, 0.011895790696144104, -0.005872443318367004, -0.006024056114256382, 0.009637627750635147, 0.011097668670117855, -0.01462501659989357, -0.004726384300738573, -0.01546754501760006, 0.010836141183972359, -0.0077176704071462154, -0.004636211320757866, -0.009075028821825981, -0.03244401514530182, -0.01727273315191269, 0.009739989414811134, 0.008518889546394348, 0.006808023434132338, -0.010661785490810871, -0.0002056617522612214, -0.009418406523764133, 0.0057193986140191555, -0.01837960258126259, -0.02663188800215721, 0.005542341619729996, -0.01911880262196064, 0.037160858511924744, 0.00946761853992939, -0.011731472797691822, 0.005846486426889896, -0.007076308596879244, 0.008637944236397743, 0.009452082216739655, 0.014108177274465561, 0.005958470515906811, -0.0051321666687726974, 0.012096459046006203, -0.037333130836486816, 0.007414042484015226, -0.00570854265242815, 0.011266857385635376, 0.010751470923423767, 0.012598303146660328, 0.022149059921503067, -0.006154072005301714, -0.004303998313844204, 0.01609540730714798, 0.01678837649524212, -0.005577509291470051, 0.021243855357170105, 0.013287985697388649, 0.07157163321971893, -0.0017282431945204735, 0.027350131422281265, 0.003894944442436099, 0.00940463226288557, 0.0008522499119862914, -0.011056043207645416, -0.019977223128080368, -0.021744903177022934, -0.008867183700203896, 0.03325149416923523, -0.021648066118359566, 0.010892458260059357, 0.011870762333273888, -0.011010192334651947, -0.001496040029451251, 0.004054976161569357, -0.015386052429676056, 0.002029610564932227, -0.00981489010155201, 0.0077019645832479, -0.019939932972192764, -0.037806250154972076, 0.011017872951924801, 0.010489868000149727, -0.015228006057441235, -0.018781516700983047, 0.001148031558841467, -0.01676381379365921, 0.04597501456737518, 0.010978582315146923, -0.0008480355609208345, 0.0010701806750148535, -0.017164897173643112, 0.020748253911733627, 0.009352358989417553, 0.006652201060205698, 0.0061540016904473305, -0.029325313866138458, 0.011747730895876884, -0.0060782842338085175, 0.014359383843839169, -0.0024823048152029514, 0.015069779939949512, 0.012764380313456059, -0.0007033511064946651, 0.0011655722046270967, 0.00003498315345495939, 0.004930696915835142, 0.015454182401299477, 0.005056071560829878, -0.0015063820173963904, 0.018536986783146858, 0.023331858217716217, 0.0009556976146996021, -0.03360195457935333, -0.017879648134112358, 0.011579422280192375, -0.01646464690566063, -0.010857587680220604, -0.0023222919553518295, -0.01170734129846096, -0.010566364973783493, -0.022207744419574738, 0.02690826542675495, 0.0045380862429738045, -0.02850567363202572, -0.021841678768396378, 0.0050569758750498295, 0.017018252983689308, 0.0024814773350954056, -0.01335154939442873, 0.009431444108486176, -0.018910100683569908, 0.03143136203289032, 0.02395399659872055, 0.021545667201280594, 0.01589081436395645, 0.030487127602100372, 0.014165986329317093, -0.009255519136786461, 0.028828749433159828, 0.004217528738081455, 0.020942527800798416, -0.006605529226362705, 0.015382876619696617, 0.008965172804892063, -0.01523934118449688, -0.00793936662375927, 0.0072920615784823895, 0.0267520509660244, -0.007605995051562786, 0.009011790156364441, 0.02832740545272827, 0.007891291752457619, 0.0352652370929718, 0.028019700199365616, -0.0002475865767337382, -0.007099113427102566, 0.002303602173924446, -0.016973992809653282, -0.02756413258612156, 0.0003231237642467022, 0.008764535188674927, -0.027517516165971756, 0.006324173882603645, 0.006428904831409454, 0.014756366610527039, -0.016265571117401123, -0.019648049026727676, 0.009485096670687199, -0.006502027157694101, -0.0012044874019920826, 0.031678661704063416, 0.007229122333228588, -0.0011585578322410583, 0.0031204931437969208, 0.007904358208179474, -0.019786542281508446, -0.010940860956907272, -0.0031848112121224403, -0.004811575636267662, -0.021202396601438522, -0.0037177186459302902, -0.002458072267472744, -0.013843867927789688, -0.011007711291313171, 0.005572789814323187, 0.020376570522785187, 0.005722197238355875, 0.022718332707881927, 0.0011887401342391968, -0.0014239349402487278, 0.009736485779285431, -0.0011661411263048649, 0.021129582077264786, 0.0444093719124794, 0.016277479007840157, 0.010450845584273338, -0.021547742187976837, 0.01521335169672966, -0.01726718433201313, -0.005471657030284405, -0.013907583430409431, 0.007003054954111576, -0.010995520278811455, 0.0061454991810023785, -0.00707526970654726, 0.010281411930918694, 0.008581481873989105, 0.002934954594820738, -0.002357536694034934, -0.0016593234613537788, -0.004687455017119646, -0.005454916972666979, 0.012907812371850014, 0.016619116067886353, -0.013091019354760647, -0.006304333917796612, -0.017110537737607956, -0.008059755899012089, -0.003293548244982958, 0.011065476574003696, 0.0035346336662769318, 0.0024465126916766167, -0.01734180375933647, 0.003781118430197239, 0.04568266123533249, -0.016546407714486122, -0.006804479286074638, 0.005988931283354759, -0.0165959894657135, -0.006215241737663746, 0.020700711756944656, -0.002162574790418148, -0.01772327721118927, -0.005324343219399452, 0.012088760733604431, -0.0036364514380693436, 0.011341387405991554, -0.01240098662674427, -0.019354652613401413, 0.012536135502159595, -0.010120291262865067, 0.000049341004341840744, -0.034588009119033813, 0.0018791324691846967, 0.003085619769990444, -0.006713775917887688, 0.0033365432173013687, 0.0116084273904562, -0.000563986599445343, -0.009335137903690338, 0.007338949479162693, 0.012408686801791191, -0.02907673269510269, -0.02282058820128441, -0.03221811354160309, 0.008468111976981163, 0.01174887828528881, -0.0005599495489150286, 0.004979969933629036 ]
[ 0.25055640935897827, -0.31741243600845337, 0.5063437819480896, -0.20793907344341278, -0.45044201612472534, -0.4263474941253662, 0.38477590680122375, -0.009208581410348415, -0.3460359573364258, -0.6818698048591614, -0.1973562240600586, -0.21678800880908966, -0.7934169173240662, 0.24049723148345947, 0.3359883725643158, 0.38272330164909363, 0.397369921207428, 0.33090510964393616, -0.3990374505519867, -0.5674287676811218, 0.08304982632398605, -0.509330153465271, 0.5270682573318481, 0.2894839644432068, 0.8770130276679993, -0.10646127164363861, 0.28936710953712463, -0.24467812478542328, 0.5921258330345154, 0.17170964181423187, -0.3974401354789734, 0.23790618777275085, -0.05649735406041145, 0.32035085558891296, -0.46129271388053894, 0.46811938285827637, -0.6875988245010376, 0.15889166295528412, 0.014130806550383568, -0.11697403341531754, -0.5136275291442871, -0.13677328824996948, -0.4564121663570404, 0.1800440102815628, -0.5452975034713745, 0.026969309896230698, -1.155705451965332, 1.1183526515960693, -0.035186536610126495, -0.0256354883313179, 0.09488403052091599, 0.4231589436531067, -0.38645854592323303, -0.16748496890068054, 0.008417940698564053, -0.20167747139930725, -0.791780412197113, 0.2173050493001938, 0.28100478649139404, -1.0661622285842896, -0.05904793366789818, 0.3679448366165161, -0.11967939883470535, 0.341307133436203, -0.2156154364347458, 0.6371004581451416, -0.13845942914485931, 0.05009466037154198, -0.2849656045436859, -0.557536780834198, 0.20821376144886017, -0.22840313613414764, -0.1352902054786682, -0.0553484708070755, -0.0031323584262281656, 0.3633948266506195, -0.07569615542888641, -0.2602798342704773, -0.21871864795684814, 0.6340169906616211, -0.35774192214012146, -0.14473898708820343, 0.4874677360057831, 0.1439935714006424, 0.634526789188385, 0.10210675746202469, -0.2854253053665161, 1.0167354345321655, -0.1946391463279724, -0.2661694884300232, 0.3581586182117462, 0.20708876848220825, 0.8333797454833984, 0.11230306327342987, 0.20909574627876282, 0.6283295154571533, 0.022125987336039543, 0.04873311147093773, 0.26392215490341187, -0.05672990530729294, -0.12273366749286652, -0.3185535967350006, -0.26088231801986694, -0.4370248019695282, -0.3511926829814911, -0.17519302666187286, -0.2935447692871094, -0.6166120171546936, -0.4738660156726837, 0.09841310977935791, -0.13922005891799927, 0.14372996985912323, -0.2951890230178833, -0.15151499211788177, 0.21109962463378906, -0.25189557671546936, 0.25087806582450867, 0.10003423690795898, 0.17831026017665863, 0.29811784625053406, -0.11334765702486038, 0.8604676723480225, -0.19295136630535126, 0.2421509027481079, -0.17972053587436676, -0.08243118971586227, -0.07298875600099564, -0.20740248262882233, -0.3720215857028961, 0.24988597631454468, 0.19799867272377014, 1.007903814315796, -0.41350385546684265, 0.534211277961731, -0.2887254059314728, 0.05739609897136688, 0.37969672679901123, 0.08558256179094315, 0.5328966975212097, 0.01419899147003889, -0.8197000026702881, -0.4328518211841583, -0.30526962876319885, 0.001104207942262292, 0.2832969129085541, -0.9149497151374817, -0.019207142293453217, -0.4387645125389099, 0.015358412638306618, -0.09509436786174774, -0.0983554869890213, -0.2714778482913971, -0.3699708580970764, -0.15705053508281708, -0.14154936373233795, -0.002958911005407572, 0.4108803868293762, 0.012152433395385742, 0.33213451504707336, 0.2778913080692291, 0.06806471943855286, -0.16278302669525146, -0.45308682322502136, 0.4136054515838623, 0.31235671043395996, 0.06272335350513458, 0.2821897864341736, 0.005074596963822842, 0.2361798733472824, -0.15115532279014587, -0.032526154071092606, 0.1345193237066269, 0.4513207972049713, -0.2502695918083191, -0.029446542263031006, -0.09392039477825165, -0.32111242413520813, -0.26284343004226685, 0.05043942108750343, -0.1213703453540802, -0.6526325345039368, -0.23872298002243042, -0.08637189865112305, -0.43887588381767273, 0.021756835281848907, 0.14107602834701538, 0.3271491229534149, -0.23504041135311127, 0.041198257356882095, -0.19799473881721497, 0.04980657622218132, 0.14231525361537933, 0.4964398145675659, -0.6622763276100159, 1.6075241565704346, -0.40658989548683167, -0.44538652896881104, 1.357434868812561, 0.23508232831954956, 0.027358999475836754, -0.13115160167217255, -0.2822163701057434, 0.8531960844993591, -0.28729286789894104, -0.04694489389657974, 0.22712041437625885, -0.21114292740821838, -0.06837054342031479, 0.15438970923423767, -0.0563151016831398, 0.015983613207936287, -0.6380088925361633, 0.003220275742933154, -0.24889704585075378, 0.3595063090324402, -0.3589162230491638, -0.4521501958370209, 0.0766695886850357, -0.13558825850486755, 0.03141433745622635, 0.20025813579559326, -0.5474871397018433, 0.08196716010570526, 0.6421379446983337, -0.2959403395652771, 0.6070815324783325, 0.410908967256546, -0.22476640343666077, 0.8942045569419861, -0.6004125475883484, 0.3854410946369171, -0.5772433280944824, -0.07110201567411423, -0.170493483543396, -0.6355743408203125, 0.07760710269212723, 0.7445322275161743, 0.15670596063137054, -0.23432421684265137, -0.13561014831066132, 0.16104179620742798, 0.7514398694038391, -0.860572874546051, 0.1219809427857399, -0.2432168424129486, -0.035302769392728806, 0.14950105547904968, 0.49843358993530273, -0.670798122882843, -0.08353326469659805, 0.34294334053993225, 0.19557607173919678, -0.07360517978668213, -0.580160915851593, 0.3396000564098358, -0.15444819629192352, -0.37523117661476135, -0.0973924845457077, 0.4326053559780121, -0.5527321696281433, -0.11014994978904724, -0.24059045314788818, -0.19275471568107605, 0.6281824111938477, -0.17960458993911743, -0.19728809595108032, -0.5930314660072327, 0.07261399179697037, 1.1323983669281006, 0.7648871541023254, 0.8185278177261353, -0.24399273097515106, -0.32645341753959656, 0.09286345541477203, -0.34405189752578735, -0.5837088227272034, 0.6845042705535889, 0.4215572774410248, -0.019175179302692413, -0.6628512144088745, -0.6533081531524658, 0.18419766426086426, 0.5747770071029663, 0.07649126648902893, 0.09569170325994492, -0.7670356631278992, -0.28377631306648254, -0.0684763714671135, -0.11654546856880188, -0.4301649332046509, -0.21549423038959503, 0.23354926705360413, -0.20850515365600586, 0.029867764562368393, -0.05324341356754303, 0.4316757023334503, -0.08770956844091415, 0.6312090754508972, 0.7585819959640503, 0.07768090814352036, -0.2332877218723297, -0.269549161195755, -0.7939924001693726, 0.2337454855442047, 0.20921757817268372, -0.06229432672262192, -0.21171601116657257, 0.4593876898288727, -5.74766206741333, 0.05448758974671364, 0.39161252975463867, 0.26939430832862854, 0.3046393096446991, -0.12640070915222168, 0.8999670743942261, 0.3250235915184021, 0.32735565304756165, 0.2057448774576187, -0.19121278822422028, 0.07909394800662994, -0.44937747716903687, 0.1646651029586792, -0.370479553937912, 0.08828794956207275, 0.43583497405052185, -0.2752044200897217, 0.318469375371933, -0.07980889081954956, 0.009746229276061058, 0.03097623772919178, 0.09751275926828384, 0.6058898568153381, 0.1169433444738388, 0.2772233784198761, -0.5330434441566467, -0.012349319644272327, -0.06188121438026428, -0.25238221883773804, -0.18262498080730438, -1.0595542192459106, 0.3122526705265045, -0.041842155158519745, 0.5178879499435425, -0.2869727611541748, 0.09217780083417892, -0.42185157537460327, -0.6471576690673828, -0.6098769307136536, 0.2668105661869049, 0.4647212028503418, -0.6510151624679565, 0.09416838735342026, 0.6628289818763733, -0.6620648503303528, -0.29820120334625244, 0.04082619398832321, -0.4510796070098877, 0.3292340934276581, -0.10635131597518921, -0.35228225588798523, -0.10227381438016891, 0.25865352153778076, 0.3092130422592163, 0.24790029227733612, -0.2674834728240967, -0.08755834400653839, -0.4836081862449646, -0.031744930893182755, -0.26495161652565, -0.002722483826801181, -0.3778436779975891, 0.239995077252388, 0.46303248405456543, 0.19806531071662903, -0.9205354452133179, -0.4649535119533539, 0.6203945875167847, -0.32076239585876465, 0.25907692313194275, 0.4434432089328766, 0.09831654280424118, -0.6045270562171936, 0.8004732728004456, -0.3186545968055725, 0.17845886945724487, -0.1966572254896164, 0.217182457447052, 0.225056454539299, -0.6536909937858582, 0.3556368350982666, 0.16240422427654266, 0.093797467648983, 0.020494520664215088, -0.45341479778289795, -0.20662438869476318, -0.02252918854355812, -0.5069832801818848, 0.2940865159034729, 0.8924903273582458, -0.13993439078330994, 0.11326293647289276, 0.4867042303085327, -0.20207777619361877, 0.34279191493988037, 0.20051580667495728, 0.5890994071960449, 0.36673539876937866, 0.2559317648410797, 0.9331598281860352, 0.15433302521705627, -0.08183197677135468, -0.8966163396835327, -0.09647693485021591, 0.28317391872406006, -0.5468390583992004, 0.7205603718757629, 0.9251623749732971, -0.6139686703681946, -0.07079602032899857, 0.10489244014024734, -0.2748483121395111, 0.0695130005478859, 0.6021002531051636, 0.06649842113256454, 0.02125674858689308, 0.3415091633796692, 0.7664235234260559, -0.4406616985797882, 0.04046778753399849, 0.22168134152889252, -0.7662341594696045, 0.18692322075366974, -0.12396002560853958, -0.2816646695137024, 0.1953469067811966, 0.45293092727661133, -0.20658443868160248, -0.6965958476066589, 0.3926926553249359, 0.29061591625213623, -0.2908620536327362, -0.09689274430274963, 0.44150543212890625, -0.6319805383682251, -0.22522816061973572, -0.356699675321579, 0.5246798396110535, -0.3568924069404602, 0.09423273056745529, -0.07995841652154922, 0.27099621295928955, 0.08355151861906052, 0.2819582521915436, 0.26766517758369446, 0.1339413821697235, 0.05386454984545708, -0.25729578733444214, -0.08385222405195236, 0.2687821686267853, -0.014316544868052006, -0.08435838669538498, -0.3919130563735962, -0.1579333245754242, 0.29229697585105896, 0.5761505961418152, -0.08757711946964264, 0.7810953259468079, -0.5107349157333374, 0.10312116146087646, 0.06178489327430725, -0.9733362793922424, 0.22740256786346436, -0.6431795358657837, -0.4230022430419922, -0.2050326019525528, -0.5719651579856873, -0.0627070963382721, 0.07553661614656448, -0.26924848556518555, -0.22710390388965607, -0.3978786766529083, -0.20819957554340363, -0.0038536451756954193, -0.4260467290878296, -0.6305944919586182, -0.09529874473810196, -0.11316544562578201, -0.19940485060214996, -0.05391417071223259, -0.34018829464912415, -0.5194435715675354, 0.45243141055107117, 0.5550623536109924, 0.16074678301811218, -0.14714668691158295, 0.3949386477470398, -0.06595809757709503, -0.24098581075668335, -0.12785840034484863, 0.09604489058256149, 0.1372385174036026, 0.07065064460039139, -0.040972720831632614, 0.43166303634643555, -0.11371573805809021, 0.6484594345092773, -0.2769213914871216, -0.22940824925899506, 0.27796536684036255, 0.4331143796443939, -0.7425708770751953, -0.04868590086698532, -0.11929037421941757, 0.5147298574447632, -0.25106096267700195, 0.058781303465366364, 0.4112192690372467, -0.08143115788698196, -0.22547322511672974, -0.23418471217155457, -0.11948680132627487, 0.4227900505065918, -0.03372213989496231, 0.002488020807504654, 0.16576984524726868, -0.5666397213935852, -0.41662079095840454, 0.5419626832008362, -0.243197962641716, 0.44612833857536316, -0.17740893363952637, 0.06611074507236481, -0.31448325514793396, -0.07494046539068222, 0.22445935010910034, -0.6018436551094055, 0.21248625218868256, 0.3392191529273987, 0.443021297454834, 0.15877725183963776, 0.1141137182712555, 0.2876605987548828, -0.41040512919425964, -0.20609180629253387, 0.24681086838245392, 0.1870618462562561, 0.07236465811729431, 0.679133951663971, 0.21011832356452942, 0.2774163782596588, -0.57584148645401, -0.11545779556035995, 0.2683713734149933, 0.48103249073028564, 0.39453762769699097, -0.34909766912460327, -0.46831783652305603, 0.008965554647147655, 0.8264712691307068, -0.03062240593135357, -0.03983292356133461, 0.6329604983329773, 0.7895449995994568, -0.6241269111633301, 0.0884825587272644, -0.01576843671500683, 0.11004704982042313, 0.005502612330019474, -0.1257704198360443, 0.4095180332660675, -0.49336397647857666, 0.20195446908473969, -0.013515476137399673, -0.02750089019536972, -0.5192552804946899, -0.7516350150108337, 0.5256201028823853, -0.06657543778419495, -0.1209070011973381, 0.31411537528038025, 0.8835923671722412, 0.43594658374786377, -0.16127654910087585, 0.6165964007377625, -0.1703302413225174, 0.21632367372512817, -0.31024304032325745, 0.18135979771614075, -0.5356574654579163, -0.551118016242981, 0.26096346974372864, -0.5845282077789307, 0.1335698664188385, -1.2790539264678955, 0.16088782250881195, -0.5567167401313782, -0.059204116463661194, -0.12038935720920563, -0.44496530294418335, -0.020576240494847298, -0.5702848434448242, -0.7343738675117493, 0.0253981314599514, 0.1967642903327942, -0.10129325836896896, 0.0773191750049591, 0.062447432428598404, 0.25223928689956665, -1.188126564025879, 0.06682608276605606, 0.15060625970363617, -0.5744566917419434, -0.36664795875549316, 0.23854590952396393, 0.37435775995254517, -0.07022169977426529, -0.6173994541168213, -0.35956069827079773, 0.08619648218154907, -0.29185056686401367, 0.08440931141376495, -0.11849018186330795, -0.6676417589187622, 0.31336334347724915, 0.10585498809814453, -0.31637024879455566, 0.05082017555832863, 0.4056679308414459, 0.3635346591472626, 0.8809645771980286, 0.09203571826219559, 0.09659309685230255, 0.0973256304860115, 0.30844423174858093, 0.39301514625549316, 0.114647276699543, 0.12416303157806396, 0.45506662130355835, 0.30696067214012146, 0.04341915249824524, -0.2572079598903656, 0.7923474907875061, 0.4830273985862732, -0.1559808850288391, 0.4839710295200348, -0.7593927383422852, -0.612791121006012, 0.1338871270418167, 0.4963071048259735, 0.8826592564582825, -0.21895049512386322, -0.5634404420852661, -0.19180309772491455, 0.36687228083610535, 0.44616663455963135, 0.21289484202861786, -0.12010591477155685, 0.4452778995037079, 0.3907923698425293, -0.6109687089920044, -0.5615517497062683, 0.09949082136154175, -0.6342986822128296, 0.18823055922985077, 0.6680307984352112, -0.4322982132434845, -0.49614208936691284, -0.1967230588197708, -0.39128240942955017, 0.3401220440864563, -0.06481944024562836, 0.5678771138191223, -0.3861277103424072, 0.4402489960193634, 0.3477141261100769, 0.2383843958377838, 0.13333281874656677, -0.24632355570793152, 0.06374605745077133, 0.020573800429701805, 0.02358894981443882, 0.13493476808071136, 0.16604404151439667, -0.4089812636375427, 0.15389253199100494, 0.24044838547706604, -0.18674886226654053, 0.2150692492723465, -0.06876842677593231, 0.7987920045852661, -0.23249676823616028, -0.39280879497528076, -0.25415515899658203, -0.7300443649291992, -0.27766937017440796, -0.6335921287536621, -0.1293560415506363, 0.3272491991519928, -0.24074189364910126, -0.45561009645462036, 0.19887620210647583, 0.339683473110199, 0.6340535879135132, 0.31859683990478516, -0.023588843643665314, 0.4061991274356842, 0.013321641832590103, 0.7254218459129333, 0.14774248003959656, 0.46379414200782776, 0.05153393745422363, 0.23348544538021088, -0.4902482330799103, 0.47448962926864624, -0.6762087345123291, -0.4938589632511139, -0.037901878356933594, -0.01851770281791687, 1.3283213376998901, 0.6564731597900391, -0.313620001077652, 0.3310985863208771, 0.438285231590271, -0.10241896659135818, 0.4280063807964325, -0.7846965789794922, -0.27709510922431946, -0.578268826007843, -0.19559364020824432, -0.1894965022802353, 0.2772466242313385, 0.46051332354545593, -0.34949591755867004, -0.09985385090112686, 0.6310817003250122, -0.04792238771915436, -0.2537630796432495, 0.0598360151052475, -0.2718099057674408, -0.27800512313842773, -0.5678822994232178, 0.32190585136413574, -0.6287779211997986, 0.12122306227684021, -0.28121107816696167, 0.0011062283301725984, 0.027203962206840515, -0.3099733889102936, 0.6838394403457642, -0.08836296945810318, 0.09615980833768845, 0.11973009258508682, 0.1427491009235382, 0.35370683670043945, -0.17658454179763794, -0.38838431239128113, -0.20482762157917023, 0.0637545958161354, 0.26094934344291687, -0.3604108393192291, -0.15149161219596863, 0.4211565852165222, -0.42069655656814575, -0.10692853480577469, -0.21870744228363037, -0.3217262625694275, -0.2558417022228241, 0.2348850816488266 ]
BACKGROUND Artemisinin derivatives used in recently introduced combination therapies (ACTs) for Plasmodium falciparum malaria significantly lower patient infectiousness and have the potential to reduce population-level transmission of the parasite. With the increased interest in malaria elimination, understanding the impact on transmission of ACT and other antimalarial drugs with different pharmacodynamics becomes a key issue. This study estimates the reduction in transmission that may be achieved by introducing different types of treatment for symptomatic P. falciparum malaria in endemic areas. METHODS AND FINDINGS We developed a mathematical model to predict the potential impact on transmission outcomes of introducing ACT as first-line treatment for uncomplicated malaria in six areas of varying transmission intensity in Tanzania. We also estimated the impact that could be achieved by antimalarials with different efficacy, prophylactic time, and gametocytocidal effects. Rates of treatment, asymptomatic infection, and symptomatic infection in the six study areas were estimated using the model together with data from a cross-sectional survey of 5,667 individuals conducted prior to policy change from sulfadoxine-pyrimethamine to ACT. The effects of ACT and other drug types on gametocytaemia and infectiousness to mosquitoes were independently estimated from clinical trial data. Predicted percentage reductions in prevalence of infection and incidence of clinical episodes achieved by ACT were highest in the areas with low initial transmission. A 53% reduction in prevalence of infection was seen if 100% of current treatment was switched to ACT in the area where baseline slide-prevalence of parasitaemia was lowest (3.7%), compared to an 11% reduction in the highest-transmission setting (baseline slide prevalence = 57.1%). Estimated percentage reductions in incidence of clinical episodes were similar. The absolute size of the public health impact, however, was greater in the highest-transmission area, with 54 clinical episodes per 100 persons per year averted compared to five per 100 persons per year in the lowest-transmission area. High coverage was important. Reducing presumptive treatment through improved diagnosis substantially reduced the number of treatment courses required per clinical episode averted in the lower-transmission settings although there was some loss of overall impact on transmission. An efficacious antimalarial regimen with no specific gametocytocidal properties but a long prophylactic time was estimated to be more effective at reducing transmission than a short-acting ACT in the highest-transmission setting. CONCLUSIONS Our results suggest that ACTs have the potential for transmission reductions approaching those achieved by insecticide-treated nets in lower-transmission settings. ACT partner drugs and nonartemisinin regimens with longer prophylactic times could result in a larger impact in higher-transmission settings, although their long term benefit must be evaluated in relation to the risk of development of parasite resistance.
[ 0.022270463407039642, 0.0049399808049201965, -0.011370712891221046, 0.011614495888352394, 0.020915981382131577, -0.022962115705013275, 0.011733152903616428, 0.00823490135371685, -0.01459924504160881, -0.022064879536628723, -0.008595295250415802, 0.01246227789670229, -0.026744410395622253, 0.026006514206528664, -0.023743297904729843, -0.006464263889938593, -0.011104458943009377, 0.009696532040834427, 0.015791619196534157, 0.01089268084615469, 0.01451229676604271, 0.007209116593003273, 0.012509623542428017, 0.007893003523349762, 0.013212098740041256, 0.011687837541103363, 0.01397832203656435, -0.014468506909906864, -0.01610121876001358, 0.026885727420449257, 0.017316484823822975, 0.015176892280578613, 0.007690735161304474, 0.007665893528610468, 0.01156432181596756, 0.02220204658806324, -0.0027258391492068768, 0.0223383828997612, 0.016447806730866432, -0.005833683535456657, -0.000306570902466774, -0.014485824853181839, 0.0006229648133739829, -0.017385689541697502, -0.010909467935562134, -0.020177878439426422, -0.0024765152484178543, -0.010822506621479988, -0.002098225522786379, 0.005359225906431675, -0.004473117180168629, -0.031687892973423004, -0.009796053171157837, 0.016614820808172226, -0.007717564702033997, -0.013592996634542942, 0.02063676528632641, 0.013787574134767056, -0.022088125348091125, -0.00702004786580801, 0.001823309576138854, 0.0038814349099993706, -0.028474915772676468, 0.009418965317308903, -0.010054545477032661, -0.0668087974190712, 0.016933295875787735, 0.018768824636936188, -0.0076660229824483395, -0.013742448762059212, -0.01134464517235756, 0.01494901068508625, -0.007318704389035702, -0.021486716344952583, -0.017607087269425392, -0.021788857877254486, -0.0011424380354583263, 0.042824119329452515, -0.008045623078942299, 0.009363451972603798, -0.005078705959022045, -0.0027304315008223057, -0.0003142957575619221, 0.01335107535123825, -0.029828406870365143, 0.019886590540409088, -0.020622245967388153, 0.015609725378453732, -0.0034460932947695255, -0.0167666207998991, -0.00716056302189827, 0.010394243523478508, -0.017907870933413506, -0.0050272345542907715, 0.008503230288624763, -0.02802322432398796, 0.004186271224170923, -0.000006549060344696045, -0.003653308842331171, 0.00559257110580802, -0.025250129401683807, -0.017408285290002823, 0.016748744994401932, -0.007610811851918697, 0.014820225536823273, 0.004355976358056068, -0.019289912655949593, -0.0031841027084738016, -0.01369238831102848, 0.01085658185184002, -0.0371917262673378, 0.00031054113060235977, 0.003067700657993555, 0.015763981267809868, 0.003115592524409294, 0.031158074736595154, -0.005827838089317083, 0.020971622318029404, 0.01429602038115263, 0.014562245458364487, 0.02247936837375164, 0.011218339204788208, 0.012360659427940845, -0.005609334446489811, -0.0018166432855650783, -0.004476536531001329, 0.011853067204356194, 0.013745373114943504, 0.015095846727490425, 0.0035993927158415318, -0.00891884882003069, 0.004168689250946045, 0.020334413275122643, 0.009656617417931557, 0.005084475036710501, 0.013056555762887001, -0.00809975154697895, -0.016099076718091965, -0.0001420523039996624, -0.01167344767600298, -0.00855285208672285, 0.01210920698940754, -0.001490709139034152, 0.01661529578268528, 0.019713619723916054, 0.00402646092697978, -0.03510063886642456, 0.014122040010988712, 0.006452711299061775, 0.019479110836982727, 0.021117430180311203, 0.003952516242861748, -0.002263428643345833, -0.016551941633224487, -0.0163237564265728, -0.0019823925103992224, 0.0013935081660747528, -0.0029238522984087467, -0.018302109092473984, 0.009974222630262375, -0.029592467471957207, 0.0007243063300848007, 0.0066323718056082726, 0.009759948588907719, 0.0050230068154633045, -0.002082178834825754, 0.016027599573135376, -0.020034482702612877, 0.012091604992747307, 0.007759644649922848, -0.011042365804314613, 0.020959947258234024, 0.009921958670020103, 0.0057619172148406506, 0.004420837853103876, 0.0023937716614454985, 0.005328754894435406, 0.010433277115225792, -0.012112591415643692, 0.06665027141571045, -0.017208946868777275, -0.01613914594054222, 0.03584375977516174, -0.03257323056459427, 0.015358688309788704, -0.006971732247620821, 0.025787755846977234, -0.003270588582381606, 0.01853119768202305, 0.03738651052117348, 0.0008571790531277657, -0.02545972540974617, -0.025249391794204712, 0.015570070594549179, -0.030327104032039642, 0.0035874033346772194, -0.000357865821570158, 0.01110056322067976, -0.0033581270836293697, 0.022718967869877815, 0.01108173094689846, -0.012341798283159733, 0.03943054378032684, -0.030360786244273186, 0.029789552092552185, 0.016964955255389214, -0.01624644733965397, -0.017522821202874184, -0.005502054002135992, -0.01456222590059042, 0.022666554898023605, 0.002107603009790182, -0.00980980321764946, 0.0001464163651689887, -0.013087145052850246, -0.00015407160390168428, -0.0016162712126970291, -0.004227814730256796, -0.008096717298030853, -0.013187766075134277, -0.008990660309791565, 0.018286483362317085, -0.022382715716958046, 0.0014720724429935217, 0.015462747775018215, 0.005971455946564674, 0.008264278061687946, 0.013861583545804024, 0.029136408120393753, 0.0038192030042409897, -0.009462658315896988, -0.03300689905881882, -0.02048313617706299, 0.026279661804437637, 0.007816868834197521, 0.010198207572102547, 0.01666857674717903, -0.016105828806757927, 0.021014291793107986, -0.01978243514895439, -0.00891941599547863, 0.013885553926229477, 0.00023724575294181705, 0.002100275829434395, 0.023032886907458305, -0.0072866166010499, 0.03275211155414581, -0.011744579300284386, -0.030153486877679825, -0.017377018928527832, 0.005252910312265158, -0.007127122953534126, -0.014520484954118729, 0.01887512393295765, -0.0036877142265439034, -0.01818663999438286, -0.00596945034340024, 0.005919141694903374, 0.02562634088099003, 0.0051417360082268715, -0.0033058139961212873, 0.004804737865924835, -0.03429355472326279, -0.002577667823061347, 0.022508446127176285, 0.024244921281933784, -0.003608596744015813, 0.00110700074583292, -0.01884102076292038, 0.012993291020393372, 0.011884180828928947, -0.001602869015187025, -0.00461690966039896, -0.0811038389801979, -0.020183008164167404, -0.008966353721916676, -0.031766463071107864, 0.0031430397648364305, 0.00502342265099287, 0.00010054046288132668, -0.003635035827755928, -0.01853567361831665, -0.007874663919210434, 0.01859060674905777, 0.04014399275183678, -0.009171073324978352, -0.03127457946538925, -0.005304212216287851, 0.006684390362352133, 0.006906614638864994, 0.0006133125862106681, 0.010437875054776669, 0.00533778453245759, -0.012370334938168526, 0.02026074379682541, 0.020935626700520515, -0.02442759834229946, -0.0025103120133280754, 0.011784710921347141, -0.010913283564150333, 0.013834073208272457, -0.007848018780350685, 0.0048524742014706135, 0.021640677005052567, -0.03003540262579918, -0.015232089906930923, 0.014028964564204216, 0.0010452719870954752, -0.0032158116810023785, -0.0016730937641113997, -0.00934479758143425, -0.000996303278952837, 0.008843780495226383, 0.0004602299304679036, 0.014400174841284752, 0.010849865153431892, 0.011824967339634895, 0.011414472945034504, 0.009228461422026157, 0.029417071491479874, 0.021175438538193703, 0.01118879858404398, -0.012090029194951057, -0.029349569231271744, -0.002583747962489724, 0.024902887642383575, 0.023558424785733223, -0.013952070847153664, -0.025460507720708847, 0.03748946264386177, 0.000706174410879612, -0.010873880237340927, -0.014767318964004517, -0.01570882275700569, -0.020965825766324997, 0.0278210137039423, -0.01612166129052639, -0.03310193866491318, 0.012210888788104057, 0.016974207013845444, 0.00223352899774909, -0.0011459402740001678, 0.005476698279380798, -0.0004281592555344105, -0.005613873712718487, 0.0026982200797647238, -0.005180480889976025, -0.002902340143918991, -0.011966826394200325, -0.01538788340985775, -0.009361199103295803, 0.009256686083972454, 0.011589041911065578, -0.009904160164296627, 0.0045234584249556065, 0.0079294852912426, 0.01996404305100441, -0.019274242222309113, -0.017573080956935883, 0.018998045474290848, -0.003681313246488571, -0.003241416532546282, -0.013519971631467342, 0.011174570769071579, 0.01958891749382019, -0.02587161585688591, 0.010187097825109959, 0.0021047485060989857, -0.014844762161374092, -0.0032022285740822554, 0.011928044259548187, 0.0021722549572587013, 0.011227613314986229, 0.015528780408203602, -0.004325450398027897, -0.029616309329867363, -0.015492802485823631, -0.040536608546972275, 0.009529003873467445, -0.005581132136285305, -0.0015838555991649628, -0.012028138153254986, -0.005820538382977247, -0.011735915206372738, 0.03170348331332207, -0.0006711688474752009, 0.026599694043397903, 0.010283153504133224, 0.011806043796241283, 0.0036399196833372116, 0.011257859878242016, 0.07203478366136551, -0.002498459303751588, 0.00009002629667520523, -0.017139915376901627, 0.013984022662043571, -0.028584051877260208, -0.00919377151876688, 0.01326540857553482, 0.004719240590929985, 0.012020697817206383, 0.013632211834192276, 0.003256120951846242, 0.006325306370854378, -0.006305006332695484, -0.029401244595646858, -0.026327118277549744, -0.009317401796579361, -0.023532375693321228, 0.030358482152223587, 0.008018216118216515, 0.009845615364611149, -0.033611640334129333, 0.00741321686655283, -0.028997056186199188, 0.024633707478642464, 0.01876123808324337, 0.022882185876369476, -0.007890565320849419, -0.015578243881464005, 0.007099101319909096, -0.0061458623968064785, -0.005010711960494518, -0.009370515123009682, -0.006362169049680233, -0.015142017044126987, 0.011254792101681232, -0.04739764332771301, 0.007354285102337599, -0.001576123759150505, -0.007925506681203842, 0.02583857998251915, -0.01277206651866436, -0.03465590626001358, 0.002150826621800661, 0.0015912968665361404, 0.018194397911429405, 0.005002201534807682, -0.012747539207339287, 0.01186937466263771, 0.0027974406257271767, -0.014155793003737926, -0.0022076652385294437, 0.015176169574260712, 0.022540854290127754, 0.004328951705247164, -0.026481887325644493, -0.005778114311397076, 0.008227501064538956, -0.003267955034971237, 0.0018854287918657064, -0.021758103743195534, 0.012087292037904263, 0.026454079896211624, -0.026506002992391586, 0.003141815308481455, -0.017790574580430984, -0.004767059814184904, 0.006733649875968695, -0.04419561102986336, -0.004050631076097488, 0.0071077351458370686, 0.004198221489787102, 0.0051847780123353004, 0.003745501395314932, -0.051891028881073, -0.056745678186416626, -0.024564094841480255, 0.016061533242464066, 0.043352704495191574, -0.018424436450004578, -0.003677413798868656, 0.0051587303169071674, 0.02706121653318405, -0.002786757657304406, -0.02441171184182167, 0.01615940034389496, -0.001630506943911314, -0.07420842349529266, 0.0007528066635131836, 0.007691013626754284, -0.0019308137707412243, -0.010579155758023262, -0.02863307110965252, -0.02258109673857689, -0.0048532369546592236, 0.0037608714774250984, -0.002962385071441531, 0.007495394442230463, 0.01986665651202202, 0.0020331658888608217, -0.01740420050919056, 0.014657819643616676, -0.0012988601811230183, -0.021673936396837234, -0.015771379694342613, -0.023804984986782074, -0.0057938904501497746, -0.005085951182991266, -0.01464143767952919, -0.02934921905398369, 0.0028324630111455917, 0.0057698823511600494, -0.08094654977321625, -0.036606959998607635, -0.002560389693826437, -0.007623905781656504, 0.0012086238712072372, 0.012797202914953232, 0.021761411800980568, -0.02659619227051735, 0.0034802942536771297, -0.015653619542717934, -0.022895172238349915, -0.01891624554991722, -0.0057651810348033905, 0.0029149281326681376, 0.012710019946098328, -0.00861905887722969, 0.02090591937303543, -0.01303753349930048, -0.003204390173777938, 0.009490234777331352, -0.005660887807607651, -0.019098935648798943, -0.01032625138759613, -0.012978828512132168, -0.010076300241053104, 0.00016756216064095497, -0.00042674760334193707, 0.012010125443339348, 0.016845712438225746, -0.004954471718519926, 0.014167506247758865, -0.013276396319270134, 0.00000740494579076767, -0.009849531576037407, -0.007061882875859737, -0.014841585420072079, 0.015410512685775757, 0.010332377627491951, 0.008921639993786812, -0.017977284267544746, -0.007075606845319271, 0.010556184686720371, -0.01322810910642147, -0.0024428479373455048, -0.027654685080051422, 0.02142336592078209, 0.010030217468738556, -0.011089117266237736, 0.016830410808324814, 0.02038200944662094, 0.004449477884918451, -0.012055592611432076, -0.017525510862469673, -0.004475289955735207, 0.0284365713596344, 0.0016837490256875753, -0.006290161982178688, 0.012848716229200363, -0.018699944019317627, 0.008553736843168736, 0.003672909690067172, 0.01045398972928524, 0.032717399299144745, 0.07145102322101593, 0.007531383540481329, 0.01606590673327446, -0.023605434224009514, -0.009922262281179428, 0.0015763463452458382, 0.01639612764120102, -0.009586203843355179, 0.002060157246887684, -0.01897602714598179, -0.01251138374209404, 0.0014756107702851295, 0.013857821002602577, 0.0180620476603508, -0.00605583842843771, -0.025322122499346733, -0.007853512652218342, 0.03729427605867386, 0.011855121701955795, 0.015537185594439507, -0.029911814257502556, -0.005619669333100319, -0.03259848803281784, 0.004419058561325073, 0.0038175047375261784, -0.010838635265827179, -0.008688593283295631, 0.00399226788431406, 0.007023983635008335, 0.003448161296546459, 0.003208062844350934, 0.003585368860512972, -0.0009440283174626529, 0.02721504122018814, 0.00943406205624342, 0.01722555235028267, 0.004360556602478027, 0.008110035210847855, 0.034220822155475616, 0.024233680218458176, 0.0015523731708526611, -0.003273942042142153, 0.0000575394369661808, -0.01904098503291607, 0.018389441072940826, 0.004365992266684771, -0.007474251091480255, 0.015033310279250145, -0.00024358532391488552, -0.007604170590639114, 0.004461886361241341, 0.011848744004964828, -0.012325594201683998, -0.012637840583920479, 0.0017694879788905382, 0.005599943920969963, -0.008690500631928444, 0.02555062621831894, -0.017054006457328796, -0.0034430555533617735, -0.005338393617421389, -0.010979143902659416, 0.005092819686979055, -0.012889102101325989, 0.013994641602039337, -0.016186300665140152, 0.015105003491044044, -0.010317391715943813, 0.0005465028807520866, 0.0159536711871624, -0.012118751183152199, 0.0008028608281165361, 0.006605330854654312, 0.006849090568721294, 0.02954760193824768, 0.01444484293460846, -0.002834776183590293, -0.02677934803068638, -0.004576461855322123, -0.009697217494249344, -0.008444692939519882, 0.004123545717447996, 0.029198572039604187, 0.006405224092304707, -0.012125015258789062, 0.019436180591583252, 0.005238533020019531, 0.0035407887771725655, 0.001849667401984334, 0.011272931471467018, 0.03094077669084072, 0.011097272858023643, -0.0037532926071435213, 0.0021742298267781734, 0.0037231948226690292, 0.03438501060009003, 0.0019716015085577965, 0.0008559670532122254, -0.006939397193491459, 0.012396137230098248, -0.0241394080221653, -0.014203079044818878, -0.010594390332698822, 0.029012814164161682, -0.007637371309101582, -0.0027317903004586697, 0.023538798093795776, -0.014037755317986012, -0.005006659775972366, -0.002522748429328203, -0.0186630692332983, 0.024171117693185806, -0.007022269535809755, 0.018230097368359566, 0.022453419864177704, 0.015558408573269844, -0.0176098495721817, -0.007721194066107273, 0.016664404422044754, -0.013248453848063946, -0.012659192085266113, -0.031244147568941116, -0.027775859460234642, 0.03186636418104172, -0.025921925902366638, -0.007490021176636219, -0.011728838086128235, 0.011009998619556427, -0.003957850392907858, -0.004001101944595575, 0.010134914889931679, -0.009034623391926289, 0.005769520532339811, -0.014469371177256107, 0.0030851999763399363, -0.010657118633389473, -0.02136659249663353, -0.009553495794534683, 0.010600102134048939, -0.040707893669605255, 0.01048011239618063, -0.005996950902044773, -0.005245807580649853, 0.0018304029945284128, 0.007869277149438858, -0.0009866708423942327, 0.005998000502586365, 0.02804621495306492, 0.00990711897611618, -0.0136673329398036, -0.03298376500606537, 0.004141772165894508, 0.011562320403754711, -0.0066908434964716434, 0.010392911732196808, 0.02717873826622963, -0.004494391847401857, 0.002894394099712372, -0.0033628959208726883, 0.01556524820625782, -0.027557555586099625, 0.0135151706635952, -0.008362136781215668, -0.016202330589294434, -0.002328353002667427, -0.006371586583554745, -0.03186111897230148, -0.0009386837482452393, 0.005305957049131393, -0.00922301970422268, 0.008456781506538391, -0.009306488558650017, -0.011987820267677307, 0.011442477814853191, -0.023219633847475052, -0.008869939483702183, -0.000981989549472928, -0.0005531350616365671, 0.0015327536966651678, 0.027842694893479347, 0.005588141269981861, -0.008688069880008698, 0.006726767867803574, -0.010494686663150787, 0.006104134023189545, -0.002246531192213297, -0.0015064476756379008, 0.01836133375763893, 0.011109692975878716, -0.004913034848868847, -0.007225668989121914, -0.010051721706986427, 0.0036169651430100203, -0.006591907702386379, -0.02136906236410141, -0.01950370892882347, 0.000362614169716835, -0.034527502954006195, -0.004840689245611429, 0.005483715794980526, 0.00952381081879139, -0.006847917567938566 ]
[ 0.4670674204826355, 0.0318608283996582, -0.06381110846996307, 0.012172472663223743, -0.14511995017528534, 0.17300161719322205, 0.3393256366252899, -0.2402222603559494, -0.328417032957077, -0.296469509601593, 0.34850606322288513, 0.540071964263916, -0.3349706828594208, 0.1525961011648178, -0.2458357810974121, 0.8635308742523193, 0.5771645307540894, 0.46615031361579895, -0.4740784466266632, -0.5887777209281921, -0.154231995344162, -0.2883266508579254, 0.34340423345565796, -0.2621791362762451, -0.11808508634567261, 0.0003996925079263747, 0.5337795615196228, 0.5466361045837402, -0.059023335576057434, -0.2369202971458435, 0.10699985921382904, 0.5815558433532715, 0.007905234582722187, -0.38775986433029175, 0.38773858547210693, -0.07069999724626541, 0.1832798272371292, 0.21789810061454773, 0.07235487550497055, -0.3157069683074951, -0.3933371901512146, -0.1218431293964386, -0.13664761185646057, 0.5527498126029968, 0.05664695054292679, -0.4159514605998993, -0.9851135611534119, 0.6674800515174866, -0.1534704715013504, -0.004000930115580559, 0.5384557843208313, -0.019314607605338097, 0.2580682337284088, 0.03604580834507942, 0.3704819679260254, 0.27058717608451843, -0.6813231706619263, -0.08268313109874725, 0.23469309508800507, -0.32830435037612915, -0.5558564066886902, 0.2903907895088196, -0.4440781772136688, -0.020871547982096672, -0.04378710687160492, 0.817787230014801, 0.368431031703949, 0.07858560979366302, -0.2968769669532776, 0.013541736640036106, 0.294156014919281, -0.1962984800338745, -0.41699346899986267, 0.18459250032901764, -0.1836731880903244, 0.10410468280315399, -0.00432399520650506, -0.1974770873785019, 0.5266525149345398, 0.057491496205329895, 0.2556612193584442, -0.15075403451919556, 0.3055829703807831, -0.5151651501655579, 0.5675960183143616, 0.20197394490242004, -0.01235928013920784, 0.8202962875366211, -0.27314114570617676, -0.31499290466308594, 0.02519664540886879, -0.23651212453842163, 0.3918690085411072, 0.8341445326805115, 0.01682487688958645, 0.5299416780471802, -0.056543998420238495, 0.28008008003234863, 0.4280925691127777, 0.3665767312049866, -0.10920029133558273, -0.10359272360801697, -0.242864727973938, 0.037524644285440445, -0.13311292231082916, -0.2407507449388504, -0.5386217832565308, -0.38566139340400696, -0.9340375661849976, 0.5725868940353394, -0.6405921578407288, 0.5889459848403931, 0.14349280297756195, -0.2019175887107849, -0.33341771364212036, -0.09756361693143845, 0.24066047370433807, -0.2590782642364502, -0.4506000578403473, 0.3178364634513855, -0.03616504743695259, 1.3715273141860962, -0.23567526042461395, 0.7577287554740906, 0.13889509439468384, 0.3002314865589142, 0.6648036241531372, 0.5848431587219238, -0.08858038485050201, 0.5357905626296997, 0.3416476845741272, 0.5443324446678162, -0.5471234917640686, 0.10357929766178131, 0.20330511033535004, -0.510616660118103, 0.058107130229473114, 0.7627090811729431, 0.8894688487052917, -0.09256680309772491, -0.7895282506942749, -0.27203795313835144, -0.07709534466266632, 0.19808116555213928, -0.3794884979724884, -0.2439533919095993, -0.18899893760681152, -0.04531605914235115, 0.18509627878665924, -0.1101045235991478, 0.3984159827232361, -0.4850587844848633, -0.8351675271987915, -0.025509554892778397, -0.21637053787708282, 0.1574697643518448, 0.18139007687568665, -0.29397258162498474, -0.4502098858356476, 0.19726960361003876, 0.518562912940979, 0.1676076054573059, -0.1924196481704712, -0.0807320699095726, 0.6068892478942871, -0.12069154530763626, -0.4462108016014099, -0.15624524652957916, 0.3722565770149231, 0.3766620457172394, -0.5889339447021484, -0.03693559765815735, -0.6048484444618225, -0.8100222945213318, 0.5547159910202026, 0.06650420278310776, 0.0640236958861351, 0.013934149406850338, 0.15099996328353882, -0.15283708274364471, -0.5030409097671509, -0.21321600675582886, -0.12629832327365875, -1.0536597967147827, 0.31435367465019226, 0.5112202167510986, 0.5251544713973999, 0.13554751873016357, 0.4305923283100128, -0.18360336124897003, -0.758828341960907, -0.06764709204435349, 0.5083090662956238, -0.5880666375160217, 1.5760037899017334, -0.2807793617248535, -0.4327070713043213, 1.0697070360183716, 0.4596424102783203, -0.005472276359796524, 0.016056086868047714, 0.3475099205970764, 0.35821789503097534, -0.10266143083572388, -1.406681776046753, -0.05287688970565796, 0.18891294300556183, -0.18002824485301971, 0.07345407456159592, 0.39909303188323975, 0.750674843788147, -0.3257676064968109, -0.20116235315799713, -0.44956496357917786, -0.07049417495727539, 0.08151542395353317, -0.03903461620211601, 0.2069627344608307, 0.11572609096765518, 0.19143599271774292, 0.21075110137462616, -0.6849013566970825, 0.3150765001773834, 0.8139494061470032, -0.20177127420902252, 0.8435367345809937, 0.44488149881362915, -0.1358153373003006, 0.5121716856956482, -0.29005300998687744, 0.1873946338891983, 0.045984264463186264, 0.30184775590896606, -0.6417065262794495, -0.44159990549087524, -0.2298087477684021, -0.14220638573169708, -0.23994803428649902, -0.14664623141288757, 0.21486088633537292, 0.17269988358020782, 0.5243632197380066, -0.9826976656913757, 0.3239726126194, -0.09611993283033371, -0.2328304499387741, -0.6520088911056519, 0.09739844501018524, -0.5272409319877625, -0.22734861075878143, 0.19726966321468353, 0.22623679041862488, 0.43170690536499023, -0.7265611886978149, -0.2190638780593872, 0.12498122453689575, -0.4660598635673523, -0.6670489311218262, 0.05223039165139198, -0.5557622909545898, -0.39935633540153503, 0.6533701419830322, 0.237295001745224, 0.3027127683162689, 0.12918980419635773, -0.4707134962081909, -0.487128347158432, -0.42885881662368774, 0.8230697512626648, 0.4723714590072632, 0.9082242250442505, -0.03611008822917938, -0.783539891242981, -0.16105151176452637, -0.3046584725379944, -0.644244909286499, -0.22453764081001282, 0.6901237368583679, -0.9594917893409729, -0.9064129590988159, 0.1314723789691925, 0.5855461955070496, 0.9420263767242432, -0.06172242760658264, -0.7854058742523193, -0.14948566257953644, 0.13528022170066833, -0.3254903256893158, -0.834811806678772, -0.09894056618213654, -0.12639564275741577, 0.06236882880330086, -0.43280449509620667, 0.00746132992208004, 0.37443807721138, 0.019746143370866776, -0.47193026542663574, 0.3162895143032074, 0.7138315439224243, -0.2247815877199173, 0.20649947226047516, 0.43087533116340637, 0.020314157009124756, 0.03575762361288071, -0.4440746307373047, -0.20628124475479126, -0.25252434611320496, 0.07714958488941193, -5.59871244430542, -0.1436425894498825, -0.4622598886489868, -0.06281857192516327, -0.32079437375068665, -0.13596750795841217, 1.2742201089859009, -0.4884457290172577, 0.49088963866233826, 0.24458396434783936, 0.09450000524520874, 0.6816840767860413, 0.39800509810447693, 0.09041252732276917, -0.006053578108549118, 0.2889445722103119, 0.3790726661682129, -0.24242490530014038, 0.8640562891960144, 0.36848750710487366, 0.6194209456443787, 0.1691604107618332, -0.233104407787323, 0.6987078189849854, 0.2999890148639679, 0.22665169835090637, -0.8615281581878662, 0.19036231935024261, -0.4322509467601776, -0.32194754481315613, 0.26902613043785095, -0.4649486839771271, -0.06284279376268387, -0.17532527446746826, -0.13909056782722473, -0.0017616363475099206, -0.06285470724105835, -0.20930691063404083, -0.4583444893360138, -0.470848947763443, -0.14631809294223785, 0.04147718474268913, 0.04493293911218643, 0.19804051518440247, 0.31093233823776245, -0.14185713231563568, 0.0047837430611252785, -0.04798777773976326, -0.194176584482193, 1.367963194847107, 0.11957921087741852, -0.24292206764221191, 0.33371713757514954, 0.5425447821617126, -0.2103763073682785, -0.20050542056560516, -0.18260996043682098, 0.366651713848114, -0.2105656862258911, 0.6333168148994446, 0.1541968435049057, 0.14074233174324036, 0.18722063302993774, -0.4256381690502167, -0.22439150512218475, 0.30918997526168823, -0.5715879797935486, -0.9489917159080505, 0.1395878940820694, -0.14792415499687195, -0.652970016002655, 0.3565024733543396, 0.1674519032239914, -0.7260918617248535, 0.8229110240936279, -0.11103680729866028, -0.331512451171875, 0.2470913976430893, 0.10188112407922745, -0.2759466767311096, -0.23111703991889954, -0.555258572101593, 0.5468095541000366, 0.007284040097147226, 0.08312949538230896, -0.10075373202562332, -0.2978314161300659, -0.1814858615398407, -0.008940442465245724, 0.14072588086128235, 0.8843632340431213, -0.3286409378051758, 0.27704206109046936, 0.26222607493400574, 0.520339846611023, 1.1414965391159058, 0.9841671586036682, -0.025577135384082794, 0.3600630760192871, -0.07631678134202957, 0.46981197595596313, -0.20333214104175568, -0.1521291732788086, -0.7636439204216003, 0.06339124590158463, -0.6162685751914978, -0.12112227082252502, -0.26502296328544617, 0.5838820338249207, -0.9224383234977722, 0.550041913986206, -0.08981464058160782, -0.508226215839386, 0.23332856595516205, 0.5364671349525452, -0.3132983446121216, 0.389216810464859, -0.0929638147354126, 0.3983018398284912, -0.21574948728084564, 0.24567151069641113, 0.18106016516685486, 0.12931296229362488, 0.20047105848789215, 0.08847447484731674, -0.8653740286827087, 0.20381158590316772, 0.7795318961143494, -0.6818788647651672, 0.2190723866224289, -0.12213153392076492, 0.507847785949707, -0.4500405192375183, -0.5005367994308472, -0.05577521026134491, -0.47973135113716125, -0.437171995639801, -0.007940142415463924, 0.42165371775627136, 0.027813749387860298, -0.24230608344078064, -0.16908803582191467, -0.7190079689025879, 0.600609540939331, 0.5566564798355103, 0.008988425135612488, 0.11724724620580673, -0.19009286165237427, -0.26129981875419617, 0.006813769694417715, 0.06953779608011246, 0.11878141015768051, 0.6334270238876343, -0.169546976685524, 0.08092449605464935, 0.321634441614151, 0.49754607677459717, 0.2501221299171448, -0.3449096381664276, -0.40908676385879517, 0.4934210479259491, 0.19102264940738678, -1.2127277851104736, -0.10898956656455994, 0.18770170211791992, -0.6612038612365723, -0.20483025908470154, -0.6932339072227478, 0.19735674560070038, 0.3500804007053375, -0.020138774067163467, -0.13780342042446136, -0.07699358463287354, -0.396849125623703, 0.3104606866836548, -0.007048782426863909, -0.4395759701728821, 0.41988468170166016, -0.3993866741657257, -0.4675845503807068, 0.02085002325475216, -0.26914697885513306, -0.4825386106967926, 0.3520960509777069, 0.6563553214073181, 0.4538172781467438, -0.2909141480922699, -0.6735385656356812, -0.2891213893890381, -0.33684080839157104, 0.40998727083206177, 0.007762756198644638, 0.24933235347270966, 0.04455951228737831, -0.12229416519403458, -0.3111620843410492, 0.25998586416244507, 0.14308302104473114, -0.28658097982406616, -0.6074835658073425, -0.1815369427204132, 0.9523191452026367, -0.4436782896518707, 0.5688642859458923, 0.21909381449222565, -0.47879892587661743, 0.04663997143507004, 0.11963877826929092, -0.2423083335161209, -0.47754722833633423, 0.02938060648739338, -0.39892643690109253, 0.1093253493309021, 0.36309680342674255, -0.5133763551712036, 0.288860559463501, 0.19337883591651917, -0.05457964912056923, -0.39622762799263, 0.3673170804977417, 0.38081809878349304, -0.666050910949707, -0.12073855102062225, -0.015134903602302074, -0.2772878110408783, 0.26876935362815857, 0.8734096884727478, -0.7234266400337219, -0.046633150428533554, -0.03468017652630806, -0.44554951786994934, 0.2875515818595886, 0.16792568564414978, 0.07785167545080185, -0.6686109900474548, 0.15225312113761902, -0.503440260887146, 0.11002613604068756, 0.14049386978149414, 0.33929145336151123, 0.02913166582584381, 0.2034309059381485, -0.15839284658432007, -0.6396645307540894, -0.2071012556552887, 0.1697583943605423, 0.5744163990020752, -0.4242308735847473, -0.6474303007125854, 0.10950785130262375, 0.43091168999671936, -0.10804352909326553, 0.19957296550273895, -0.5141220092773438, 0.6460206508636475, -0.044059451669454575, -0.411933958530426, -0.21874260902404785, -0.14052312076091766, 0.31017598509788513, -0.2824326157569885, -0.37587830424308777, -0.45137348771095276, -0.11257759481668472, 0.26388999819755554, -0.1060861274600029, 0.05004287138581276, -0.7764954566955566, 0.4297257363796234, -0.6034597158432007, -0.5481568574905396, -0.4988211691379547, 0.9451262950897217, 0.7992039322853088, 0.10953139513731003, 0.05436218902468681, -0.3785337209701538, -0.26581066846847534, -0.18806703388690948, 0.17288221418857574, -0.40689992904663086, -0.3423784673213959, 0.22190767526626587, -0.33420315384864807, 0.23086676001548767, -0.3949812948703766, 0.17004917562007904, -0.1474156528711319, -0.38676705956459045, -0.6007623076438904, -0.06819097697734833, 0.119451142847538, -0.5548335909843445, -0.26906126737594604, -0.021329963579773903, 0.31640082597732544, 0.2800464630126953, -0.06867101788520813, 0.5129100680351257, -0.4975016415119171, -0.2682199776172638, 0.8612596988677979, 0.3948343098163605, -0.42987728118896484, -0.004892089404165745, 0.14740437269210815, 0.42149579524993896, 0.16482998430728912, 0.030993705615401268, 0.43444862961769104, 0.21643081307411194, -0.04192310944199562, 0.3820408880710602, 0.18409474194049835, -0.040900539606809616, 0.30065837502479553, -0.15059815347194672, -0.34813952445983887, 0.848766565322876, 0.328995019197464, 0.547687292098999, 0.6014640927314758, 0.6872698664665222, 0.18791872262954712, -0.4388416111469269, 0.606431782245636, -0.5915825366973877, 0.3452011048793793, 0.2913160026073456, -0.15178917348384857, 0.22186774015426636, 0.581845760345459, -0.17661552131175995, -0.07512115687131882, 0.06909174472093582, 0.4790572226047516, 0.3379468023777008, -0.4212784767150879, -0.15522652864456177, -0.15508408844470978, 1.022566795349121, 0.04769258201122284, 0.24468758702278137, -0.29357782006263733, 0.030632181093096733, 0.42897772789001465, -0.17604465782642365, -0.216612309217453, -0.2054208368062973, 0.48092159628868103, 0.05586179718375206, -0.030028117820620537, -0.4253021776676178, -0.45117616653442383, -0.47242772579193115, 0.46356236934661865, -0.0844419077038765, -0.3541004955768585, -0.5495877861976624, 0.32179924845695496, 0.12687423825263977, -0.03961561247706413, -0.5359963178634644, 0.6058624982833862, -0.656995415687561, 0.10425571352243423, 0.40331265330314636, 0.3612132966518402, -0.004810994025319815, -0.12155274301767349, -0.12353509664535522, -0.5514944791793823, -0.13075284659862518, 0.347530335187912, 0.13216465711593628, -0.6873136758804321, 0.24667157232761383, 0.25491830706596375, -0.13242660462856293, 0.43435314297676086, -0.23866258561611176, 0.49381715059280396, -0.5081241130828857, -0.23156403005123138, 0.03479156643152237, -0.3859393298625946, -0.5987854599952698, 0.16910050809383392, 0.12709422409534454, -0.11860140413045883, 0.3164825737476349, -0.404751718044281, 0.017703359946608543, 0.4900680482387543, -0.3169388175010681, -0.0772586241364479, 0.285038024187088, 0.8100911378860474, -0.30225127935409546, 0.40178194642066956, -0.12049642205238342, 0.07440486550331116, -0.24888212978839874, 0.8485355377197266, -0.2507522404193878, 0.3507934510707855, -0.9771124720573425, -0.08973562717437744, -0.7894299626350403, -0.07128661870956421, 0.4170038104057312, 0.5951535105705261, -0.09615768492221832, 0.02453920617699623, 0.07884982228279114, -0.25720274448394775, 0.09255606681108475, -0.45154905319213867, -0.23673871159553528, -0.456543892621994, -0.23016774654388428, -0.7944080233573914, 0.4807087182998657, -0.12162906676530838, -0.35088521242141724, -0.563549280166626, 0.1140989139676094, 0.5645339488983154, -0.025859225541353226, 0.2288423776626587, 0.07485814392566681, -0.043661929666996, -0.7382045388221741, 0.4378475248813629, -0.3623451292514801, 0.2114337533712387, 0.14452651143074036, 0.2908715605735779, 0.30957329273223877, 0.07882722467184067, -0.20625244081020355, -0.4090026915073395, 0.26976102590560913, -0.11779247224330902, -0.007597464602440596, 0.4854184091091156, -0.12541057169437408, -0.41248607635498047, -0.5425138473510742, 0.4972623288631439, -0.3019987940788269, -0.632972776889801, -0.4589914381504059, 0.1565161645412445, -0.4682614505290985, -0.460592120885849, 0.12596461176872253, -0.624161422252655, -0.07277096807956696, -0.6980978846549988 ]
Amino-acid producers have traditionally been developed by repeated random mutagenesis owing to the difficulty in rationally engineering the complex and highly regulated metabolic network. Here, we report the development of the genetically defined L-threonine overproducing Escherichia coli strain by systems metabolic engineering. Feedback inhibitions of aspartokinase I and III (encoded by thrA and lysC, respectively) and transcriptional attenuation regulations (located in thrL) were removed. Pathways for Thr degradation were removed by deleting tdh and mutating ilvA. The metA and lysA genes were deleted to make more precursors available for Thr biosynthesis. Further target genes to be engineered were identified by transcriptome profiling combined with in silico flux response analysis, and their expression levels were manipulated accordingly. The final engineered E. coli strain was able to produce Thr with a high yield of 0.393 g per gram of glucose, and 82.4 g/l Thr by fed-batch culture. The systems metabolic engineering strategy reported here may be broadly employed for developing genetically defined organisms for the efficient production of various bioproducts.
[ 0.01407625712454319, 0.009346140548586845, -0.005937954876571894, 0.014177174307405949, -0.017642240971326828, -0.001670088735409081, 0.008808601647615433, -0.003282934660091996, -0.012893350794911385, -0.004435064271092415, -0.012699324637651443, 0.01636023446917534, -0.011984232813119888, 0.021439433097839355, -0.010452604852616787, 0.01740245148539543, -0.003538914956152439, 0.002878607250750065, 0.010547828860580921, -0.027143793180584908, 0.011375419795513153, -0.018870990723371506, 0.009526335634291172, -0.029607508331537247, 0.008961040526628494, 0.031629644334316254, 0.01098655816167593, 0.01600407436490059, 0.002736167749390006, -0.015494948253035545, 0.0013439115136861801, -0.0057656229473650455, 0.0036874848883599043, 0.019216950982809067, -0.0025822939351201057, 0.029473241418600082, 0.0033114266116172075, 0.019815102219581604, 0.039985135197639465, -0.005301402881741524, 0.0018560208845883608, -0.0130242221057415, 0.002316643251106143, -0.014399351552128792, -0.008766029961407185, -0.03311977908015251, -0.003826084779575467, 0.0068800863809883595, -0.0009640798671171069, 0.00472583482041955, -0.011215252801775932, -0.03519611805677414, -0.008747469633817673, 0.03502720966935158, -0.006022150628268719, -0.01970212161540985, 0.0167100727558136, 0.013464734889566898, 0.02852409891784191, 0.02613525092601776, 0.010425755754113197, -0.02442808449268341, -0.0190835390239954, -0.030468519777059555, 0.005879407748579979, -0.06676255166530609, 0.004798226989805698, 0.0005650175735354424, 0.0038440092466771603, -0.007413660641759634, -0.011923927813768387, 0.007025947794318199, 0.0051427558064460754, -0.018231157213449478, -0.003040023148059845, -0.008480913937091827, -0.0059845419600605965, 0.009270476177334785, 0.016679560765624046, 0.0004779025912284851, 0.010648274794220924, -0.013147279620170593, 0.003307174891233444, -0.004323254339396954, -0.03364879637956619, -0.012968203984200954, -0.018631640821695328, 0.01294872909784317, 0.006578920409083366, -0.027184676378965378, 0.003460851963609457, 0.00004639779217541218, -0.0028662490658462048, -0.014011867344379425, 0.0016410910757258534, -0.001397609245032072, -0.0004918230697512627, -0.0072048623114824295, -0.011293740943074226, 0.00720696896314621, -0.014872847124934196, 0.03959700092673302, 0.013410435058176517, -0.00667608343064785, -0.006330392323434353, 0.006673026829957962, -0.011222755536437035, 0.033549293875694275, -0.00588370393961668, 0.01241116039454937, -0.008548416197299957, 0.025864528492093086, 0.029237423092126846, 0.013165205717086792, 0.014217039570212364, 0.0007673576474189758, 0.008135238662362099, 0.01406714878976345, 0.016568409278988838, 0.012534947134554386, 0.030024174600839615, -0.015851881355047226, 0.0011438231449574232, 0.007253825198858976, 0.0015727991703897715, 0.002662450075149536, -0.01314624585211277, 0.0006002709269523621, 0.01655741222202778, -0.006139930337667465, -0.010269477032124996, 0.005306217819452286, -0.009869249537587166, -0.020774558186531067, -0.0010907326359301805, -0.001850317232310772, -0.001032231841236353, 0.013291649520397186, -0.011820697225630283, -0.0052529023960232735, 0.017908453941345215, 0.0035345207434147596, 0.001997800078243017, 0.020687803626060486, 0.02068152092397213, 0.00004074256867170334, -0.0256505124270916, -0.007468440104275942, 0.021638374775648117, -0.03479573875665665, 0.005821286700665951, -0.004461759235709906, -0.011157101020216942, -0.009878658689558506, -0.007654164917767048, 0.013497410342097282, -0.007841555401682854, -0.03827662393450737, -0.01523132249712944, 0.004858833737671375, -0.019240008667111397, -0.030501453205943108, 0.009626750834286213, 0.00880950316786766, -0.0026479815132915974, -0.006189812906086445, -0.016726026311516762, -0.007788381539285183, -0.026717474684119225, 0.00476370844990015, -0.0017484142445027828, 0.0036404700949788094, 0.028233427554368973, 0.012770997360348701, -0.008189116604626179, -0.0013332542730495334, -0.011050708591938019, 0.007879108190536499, -0.014067121781408787, 0.06630554050207138, 0.011509965173900127, -0.017675474286079407, 0.0028326152823865414, 0.012315923348069191, 0.005094004329293966, -0.0006430790526792407, -0.00650573568418622, 0.008281620219349861, -0.020319871604442596, 0.013582793064415455, 0.027261946350336075, -0.01224308181554079, -0.009718487970530987, -0.0025703292340040207, -0.0060355705209076405, 0.0011710787657648325, 0.00970541313290596, 0.002669250126928091, 0.004371472168713808, -0.00885051116347313, 0.0037777223624289036, 0.0010652379132807255, 0.0033671243581920862, 0.0007694214582443237, 0.014474178664386272, -0.002015411388128996, 0.0018232306465506554, 0.0015213806182146072, -0.009954718872904778, -0.008806485682725906, 0.017067553475499153, -0.0093381954357028, -0.00009855348616838455, -0.005438624415546656, -0.002971976064145565, 0.01881306618452072, -0.010347682982683182, 0.024679237976670265, 0.013466719537973404, -0.009658601135015488, 0.003195726778358221, -0.014718292281031609, -0.02940189279615879, 0.0005408395081758499, 0.005866754800081253, 0.00013983133248984814, 0.006711508613079786, 0.014710953459143639, -0.008613510988652706, -0.0020203334279358387, -0.01364622451364994, -0.03472539409995079, -0.013536069542169571, 0.01686910353600979, 0.015910103917121887, 0.0030897334218025208, 0.014279053546488285, -0.0010863104835152626, 0.007188566029071808, -0.010665234178304672, 0.012189742177724838, 0.01889905147254467, 0.015918614342808723, 0.007198597304522991, -0.0060540493577718735, -0.005362940952181816, 0.006668347865343094, 0.004503690171986818, 0.037920527160167694, -0.00870033260434866, 0.006975687108933926, -0.019962992519140244, -0.02247362583875656, -0.021029170602560043, 0.014721356332302094, -0.006715954281389713, -0.016307596117258072, -0.01316796150058508, 0.023228563368320465, 0.005168648436665535, 0.0022764932364225388, 0.0028648553416132927, -0.0036564995534718037, 0.00034357747063040733, -0.020758606493473053, -0.003248154418542981, 0.027626117691397667, 0.01066337339580059, 0.009112415835261345, -0.0029102384578436613, 0.009503472596406937, -0.004591878969222307, 0.0023697959259152412, -0.08102551102638245, -0.012125656008720398, -0.0008214237168431282, 0.006261098198592663, 0.005401560105383396, 0.02534046582877636, -0.005989791825413704, -0.001433897064998746, -0.016925109550356865, 0.007111521437764168, 0.01020726840943098, 0.011139164678752422, -0.011403597891330719, -0.0009807292371988297, -0.001740350155159831, -0.004393236245959997, 0.007703262381255627, -0.011313499882817268, -0.013955384492874146, -0.01723744533956051, 0.004993523471057415, 0.006550989113748074, -0.006013949401676655, -0.008792310953140259, 0.0013254391960799694, -0.007838033139705658, 0.0069554946385324, -0.0015351567417383194, -0.00777043029665947, 0.00861060805618763, -0.026163382455706596, -0.011849801056087017, 0.0045956154353916645, -0.007480883039534092, 0.0006774498615413904, 0.001252674381248653, -0.014927786774933338, -0.006764788180589676, -0.01845933124423027, 0.03423449024558067, -0.009339051321148872, 0.01437394879758358, 0.022800199687480927, 0.0005761845968663692, 0.015073232352733612, 0.014540515840053558, 0.015107309445738792, 0.02521250583231449, 0.024270735681056976, 0.02977053076028824, -0.00018041301518678665, 0.00013350037625059485, -0.0010882951319217682, 0.022031500935554504, -0.019992154091596603, -0.009315703064203262, 0.017325103282928467, 0.001859208568930626, -0.0052026971243321896, -0.00921892561018467, -0.0017185849137604237, 0.00461284164339304, 0.0015568844974040985, 0.011856375262141228, 0.013704433105885983, 0.026120217517018318, 0.014005813747644424, -0.010898160748183727, -0.007014593109488487, 0.0032313752453774214, -0.007489860989153385, 0.014223277568817139, 0.014077684842050076, -0.0037409497890621424, -0.00706894788891077, -0.010215665213763714, -0.014730006456375122, -0.00040787504985928535, -0.008231483399868011, -0.029451970010995865, 0.009052691049873829, 0.003532096277922392, -0.00629029143601656, -0.01493068691343069, -0.02124660834670067, 0.0017639808356761932, 0.007906545884907246, 0.023360872641205788, 0.012712614610791206, -0.013358681462705135, -0.0009685070253908634, 0.04322388023138046, -0.001981530338525772, 0.015210931189358234, 0.016117149963974953, -0.03218063712120056, 0.01598041132092476, 0.013197734951972961, 0.008113646879792213, 0.006337780971080065, -0.007948956452310085, -0.005477197468280792, -0.0016680723056197166, -0.008248209953308105, -0.011419354006648064, 0.007297782227396965, -0.003310416592285037, 0.029163764789700508, -0.011916212737560272, 0.0003465510962996632, 0.023544158786535263, -0.0013203220441937447, 0.0005222867475822568, 0.005822294857352972, 0.011972347274422646, -0.003228872548788786, 0.0012400057166814804, 0.019295429810881615, 0.0727887749671936, 0.007243084721267223, -0.010718445293605328, -0.008942468091845512, -0.011070679873228073, 0.010600309818983078, 0.009496262297034264, 0.006280901841819286, -0.011256560683250427, -0.013838622719049454, 0.011197419837117195, -0.016736896708607674, -0.005058190785348415, 0.008757393807172775, -0.022787652909755707, -0.021807469427585602, -0.027224697172641754, -0.008732893504202366, 0.04939882457256317, -0.0012916168197989464, -0.013104544952511787, -0.025370366871356964, -0.010450338013470173, -0.010188266634941101, -0.004632908850908279, -0.0030207845848053694, -0.011539408005774021, -0.008996820077300072, -0.02343098074197769, 0.0086724404245615, 0.01847754791378975, 0.004441991914063692, -0.0071781533770263195, -0.007941081188619137, 0.013146295212209225, 0.015807295218110085, 0.029510589316487312, 0.005717777647078037, 0.006659999489784241, -0.013693532906472683, -0.002800232730805874, -0.015708787366747856, -0.0015676832990720868, 0.009442999958992004, -0.011884139850735664, 0.0014681760221719742, 0.024765189737081528, -0.003970042336732149, -0.0009250896982848644, -0.003410576842725277, -0.0067945849150419235, 0.004774975124746561, 0.012960315681993961, -0.0013551642186939716, -0.004082093946635723, -0.027696829289197922, 0.02452842704951763, -0.010789409279823303, 0.01532167848199606, -0.03689907491207123, 0.0010929042473435402, -0.035142794251441956, 0.006277892738580704, -0.014621872454881668, 0.017456501722335815, -0.025275474414229393, -0.012787564657628536, 0.002467676531523466, 0.0026167696341872215, 0.017870398238301277, -0.007523294072598219, -0.016355562955141068, -0.018552141264081, 0.017985191196203232, -0.02088996022939682, 0.020832471549510956, -0.0021662956569343805, 0.003375489264726639, 0.000672975555062294, -0.0003676575142890215, 0.011068325489759445, 0.0159139446914196, -0.01132439635694027, 0.031128522008657455, 0.02160440757870674, -0.0032202634029090405, -0.0190007034689188, -0.07497350871562958, -0.0016067307442426682, 0.0004826304502785206, -0.0015270792646333575, 0.021742086857557297, 0.003926808945834637, -0.01368067879229784, 0.01113441213965416, 0.0011609483044594526, 0.003363700583577156, 0.022109203040599823, -0.0037952009588479996, 0.0031845238991081715, 0.016556516289711, 0.010775270871818066, 0.020245404914021492, -0.010076268576085567, 0.0076652346178889275, -0.002876524580642581, 0.00444873608648777, -0.015199212357401848, -0.030380865558981895, -0.02686256915330887, 0.005604664795100689, -0.014437091536819935, -0.08168631792068481, 0.0046251388266682625, -0.014883456751704216, -0.0017603114247322083, 0.005561026744544506, 0.018588107079267502, 0.00724810641258955, -0.007778744213283062, 0.015747645869851112, -0.015824856236577034, -0.004852777812629938, -0.002533688908442855, -0.007629671134054661, 0.003576467279344797, -0.0031718388199806213, -0.003950280137360096, 0.017203159630298615, -0.007339300587773323, -0.005258101038634777, 0.01116415299475193, -0.00302616273984313, 0.006351352669298649, -0.0071208844892680645, -0.015399111434817314, -0.0035045805852860212, -0.0006325847934931517, 0.0018029585480690002, 0.012546507641673088, -0.002333747921511531, 0.02249809354543686, -0.003449677024036646, -0.0035840612836182117, -0.016164187341928482, -0.013289172202348709, -0.004180449992418289, -0.014396668411791325, 0.006474268157035112, -0.011526286602020264, -0.0028131743893027306, -0.010842857882380486, -0.007238411344587803, 0.002660986501723528, 0.022860761731863022, 0.00016721710562705994, 0.008301465772092342, 0.0035437452606856823, 0.006252600345760584, -0.007511621806770563, 0.011448385193943977, -0.008751651272177696, 0.0003163558430969715, -0.004837143234908581, -0.01144280843436718, 0.0021696025505661964, 0.011026623658835888, 0.00498426565900445, -0.001579143456183374, 0.014377434737980366, 0.003045915625989437, -0.00345062930136919, -0.002725424710661173, 0.011870171874761581, 0.001334992703050375, 0.0712999701499939, 0.01250479556620121, 0.00036286748945713043, 0.0032895770855247974, -0.0008865708950906992, -0.00017744838260114193, -0.002805119613185525, 0.009216362610459328, -0.02012648619711399, -0.0049830833449959755, 0.011273551732301712, -0.01103673130273819, 0.01595870777964592, 0.01237775944173336, 0.008296562358736992, -0.020465988665819168, 0.0011038105003535748, 0.025737499818205833, -0.012008395045995712, 0.021034426987171173, -0.0027799620293080807, -0.00716272322461009, -0.03168506920337677, -0.0244080051779747, -0.01569652557373047, -0.006509860977530479, -0.018146703019738197, 0.003446318209171295, -0.026309333741664886, 0.045327916741371155, -0.01587948016822338, 0.013877417892217636, 0.000018568302039057016, -0.010324109345674515, 0.014352675527334213, 0.009845536202192307, -0.012764548882842064, 0.011445906944572926, -0.025811120867729187, -0.015255443751811981, -0.011695139110088348, 0.0169096477329731, -0.002924431813880801, -0.02204848825931549, 0.013578679412603378, -0.021257616579532623, -0.010290587320923805, 0.01529696211218834, -0.011244856752455235, 0.0037762653082609177, 0.018852490931749344, -0.001792868017219007, -0.0203231368213892, 0.00599641352891922, -0.00045426562428474426, 0.00963483564555645, -0.00765477679669857, 0.01527517568320036, -0.01704183965921402, -0.013275970704853535, -0.011187044903635979, -0.004978418815881014, 0.007210234180092812, -0.022443801164627075, 0.007597740273922682, -0.005319420248270035, 0.00921532604843378, -0.020613454282283783, -0.008245800621807575, 0.013043640181422234, 0.005078655667603016, 0.011616647243499756, 0.005983822513371706, 0.02687063254415989, 0.035643670707941055, 0.007628053426742554, 0.02125934325158596, -0.016006119549274445, 0.023443782702088356, 0.015213150531053543, -0.01332609262317419, 0.020060405135154724, 0.028805401176214218, 0.03823832422494888, -0.027794664725661278, -0.011663408018648624, -0.01243229117244482, 0.011737470515072346, 0.004806794226169586, 0.006676920689642429, 0.01665085181593895, -0.0018045457545667887, 0.0033977804705500603, 0.024149542674422264, 0.010316073894500732, 0.03298957645893097, 0.03195585310459137, 0.009122819639742374, 0.008540373295545578, 0.013673579320311546, 0.01041224505752325, 0.010073928162455559, 0.01074281707406044, 0.006334895268082619, 0.017574802041053772, 0.0035343763884156942, -0.009017032571136951, -0.011186376214027405, 0.016845501959323883, 0.015506280586123466, 0.015124071389436722, 0.003321542637422681, 0.015784580260515213, -0.03338036313652992, 0.00010080286301672459, 0.0008823180105537176, 0.005653003696352243, -0.020254863426089287, -0.00020955153740942478, -0.014882257208228111, -0.01860521361231804, -0.016158975660800934, 0.012767764739692211, 0.036130115389823914, 0.02610490843653679, -0.010474073700606823, -0.015806887298822403, 0.002235371619462967, 0.012142115272581577, -0.020734112709760666, 0.018193211406469345, -0.03820742294192314, 0.003983937669545412, -0.015946993604302406, -0.0051276502199471, 0.012581230141222477, -0.0085064098238945, 0.015141590498387814, 0.004947239067405462, 0.016993509605526924, 0.0020982902497053146, 0.007758055813610554, -0.0048293424770236015, 0.026764119043946266, 0.008567670360207558, -0.021157393231987953, 0.011101879179477692, 0.03204701468348503, 0.00992434099316597, -0.02017061971127987, -0.016406286507844925, 0.0010112356394529343, 0.0036753336898982525, -0.009408921003341675, 0.007938646711409092, 0.02768823504447937, 0.01725167967379093, -0.024670936167240143, -0.014909032732248306, -0.012425407767295837, 0.007380856201052666, -0.006090356037020683, -0.015101073309779167, 0.0004818970337510109, 0.014476289041340351, 0.0037349644117057323, -0.02508004754781723, 0.002884451299905777, -0.010225920006632805, 0.03396360203623772, 0.014011669903993607, -0.017579760402441025, 0.0015857969410717487, 0.004301953129470348, 0.001203301828354597, -0.006317753344774246, -0.016063537448644638, -0.004349995404481888, 0.006381649058312178, -0.020835138857364655, -0.020229991525411606, -0.008717446587979794, 0.010836459696292877, -0.007103446871042252, -0.007003691978752613, -0.005928741302341223, 0.005781383253633976, -0.004485199227929115, -0.008473185822367668, -0.005826829932630062, -0.021142369136214256, -0.012916517443954945, -0.009064225479960442, 0.0009218500927090645, -0.014419179409742355, -0.01218709908425808, -0.005369014572352171, -0.010659154504537582, 0.01961750164628029, 0.004512844141572714, -0.0037981104105710983, -0.004479039926081896 ]
[ 0.20677784085273743, -0.12078920751810074, -0.05768013000488281, 0.12380190938711166, -0.13405881822109222, 0.31890472769737244, -0.43850651383399963, -0.04585551097989082, 0.26019802689552307, -0.4280346632003784, 0.30124688148498535, 0.45330530405044556, -0.853312611579895, 0.6378093361854553, 0.0873791053891182, 1.02058744430542, 0.20266829431056976, 0.6687827706336975, -0.37439149618148804, -0.14858262240886688, -0.1356433928012848, -0.21036915481090546, 0.548389732837677, 0.028451936319470406, 0.4091346859931946, 0.1290236860513687, 0.3701396882534027, 0.0949346274137497, -0.003995293751358986, 0.04167613387107849, 0.19758464395999908, 0.4413928687572479, -0.1567935198545456, 0.18777768313884735, -0.4220574200153351, -0.113460011780262, -0.48373177647590637, 0.048048533499240875, 0.015434717759490013, -0.39442798495292664, -0.5010717511177063, -0.2589675486087799, -0.32308313250541687, 0.6479070782661438, -0.559825599193573, 0.10139862447977066, -1.5674785375595093, 0.7384928464889526, -0.7507396340370178, 0.09144488722085953, -0.17841877043247223, -0.2066127359867096, 0.12993551790714264, 0.3824613094329834, 0.023234406486153603, 0.1391419768333435, -0.3864452838897705, -0.1904669553041458, 0.20214425027370453, -0.44774165749549866, 0.3931293785572052, 0.2439904510974884, -0.20520861446857452, 0.47734418511390686, -0.24703757464885712, 0.7699705958366394, -0.18733225762844086, -0.5278745889663696, -1.2463688850402832, 0.06484385579824448, 0.09887438267469406, -0.36137720942497253, -0.4458814859390259, 0.468414843082428, -0.12993775308132172, -0.4293937385082245, -0.14104637503623962, 0.045701999217271805, 0.3757706880569458, -0.15907633304595947, 0.12352559715509415, 0.5820883512496948, 0.07620644569396973, -0.37266358733177185, 0.440447598695755, 0.19673238694667816, -0.1337233930826187, 0.3188983201980591, -0.2913047671318054, -0.6176788210868835, 0.12466289103031158, 0.20435981452465057, -0.10145285725593567, 0.29363831877708435, -0.10080798715353012, -0.018768254667520523, 0.4775073826313019, -0.2851586639881134, 0.20446009933948517, 0.4163573980331421, -0.13309860229492188, -0.12606403231620789, -0.06832583248615265, -0.07795627415180206, -0.4971323013305664, -0.21737858653068542, -0.16845262050628662, -0.2443586140871048, -0.1338079869747162, 0.23468896746635437, -0.512605607509613, 0.5683371424674988, 0.12763679027557373, -0.14620943367481232, -0.05867360532283783, -0.1571514904499054, 0.062710240483284, 0.05557747930288315, -0.09359485656023026, 0.08548557013273239, 0.17341555655002594, 0.8598534464836121, -0.43153974413871765, 0.5544966459274292, -0.12051238119602203, -0.013577872887253761, -0.011290481314063072, 0.15078365802764893, -0.7283008098602295, 0.15550459921360016, 0.5062543749809265, 0.7874267101287842, -0.3178090453147888, 0.04883752763271332, -0.0243852362036705, -0.33603915572166443, 0.48882266879081726, 0.044569723308086395, 0.6635909080505371, -0.6778366565704346, -1.223864197731018, -0.4459891617298126, -0.3414657413959503, -0.2737554609775543, -0.36329880356788635, -0.6614282727241516, -0.1331443041563034, 0.02524126134812832, 0.46245795488357544, -0.1562063992023468, -0.3187014162540436, -0.6198301315307617, -0.9563992023468018, 0.04317567124962807, -0.18151363730430603, -0.040691111236810684, 0.06262096017599106, -0.09834189713001251, -0.07137706130743027, 0.5146397352218628, 0.13455268740653992, 0.01772209256887436, -0.21972621977329254, -0.3950318694114685, 0.4936409294605255, -0.7786188125610352, 0.045149460434913635, 0.5444556474685669, -0.3709613084793091, 0.06751064211130142, 0.055392973124980927, -0.4476163387298584, 0.23946094512939453, -0.5141102075576782, -0.1634669303894043, -0.044507741928100586, -0.18179728090763092, -0.10426154732704163, -0.0024618073366582394, 0.1760663241147995, -0.6978334784507751, 0.31392160058021545, 0.4134303033351898, -0.2994089424610138, -0.047439467161893845, 0.1510598212480545, 0.5064635872840881, -0.036944326013326645, -0.07892429828643799, 0.021147018298506737, -0.45163169503211975, -0.12864360213279724, 0.25967028737068176, -0.8418679237365723, 1.2109936475753784, -0.1721198856830597, -0.23789089918136597, 0.6899117827415466, -0.16749924421310425, -0.18961921334266663, -0.15945309400558472, -0.02495812065899372, 0.48423412442207336, -0.8959184288978577, -0.6561791896820068, 0.38823044300079346, 0.1311948001384735, -0.352112352848053, 0.3095475137233734, 0.07977479696273804, 0.6703824400901794, -0.35173147916793823, 0.3432968854904175, -0.15151609480381012, 0.2657677233219147, -0.2158317267894745, -0.3324233591556549, 0.1953733265399933, 0.11099150776863098, 0.1065816804766655, 0.36873018741607666, -0.5202291011810303, 0.3825303614139557, 1.0167847871780396, -0.752463161945343, 0.6512024998664856, 0.4870162010192871, 0.03491100296378136, 0.786841630935669, 0.09242900460958481, 0.638217568397522, -0.7354771494865417, 0.4167305827140808, -0.19182762503623962, -0.09341057389974594, -0.1848973035812378, -0.017433559522032738, 0.0875973030924797, 0.04437512904405594, -0.12274359166622162, -0.1270887404680252, 0.21793779730796814, -1.081742286682129, -0.35407641530036926, -0.11427095532417297, -0.6440531015396118, -0.23970799148082733, 0.22484835982322693, -0.46178731322288513, -0.3684818148612976, 0.21334661543369293, 0.35110798478126526, 0.49324876070022583, -0.3947010338306427, -0.038139741867780685, -0.07511596381664276, -0.3770834505558014, 0.06068308278918266, 0.31162846088409424, -0.4578774571418762, -0.24988991022109985, -0.21141979098320007, -0.14289802312850952, -0.1791505515575409, -0.03428009897470474, -0.010797925293445587, -0.3187125325202942, -0.38194721937179565, 0.9115527868270874, 0.520164430141449, 0.9893978238105774, 0.382481187582016, -0.6265754699707031, -0.3412034213542938, -0.595116913318634, -0.6524748206138611, 0.29709503054618835, 0.33098897337913513, -0.7710874676704407, -0.39127734303474426, 0.19626204669475555, -0.21252554655075073, 0.6720252633094788, -0.7362973690032959, -0.7121027708053589, 0.06379252672195435, -0.12251270562410355, -0.27023524045944214, -0.025502093136310577, -0.06199747323989868, -0.39010924100875854, 0.3780968487262726, -0.7859663963317871, -0.5408251881599426, 0.2426196038722992, -0.10051112622022629, -0.37404927611351013, 0.27904728055000305, 0.7200786471366882, -0.46537286043167114, -0.03801650181412697, 0.1556454300880432, -0.32461708784103394, 0.296968013048172, -0.3670799434185028, 0.09319079667329788, 0.15594002604484558, 0.502400815486908, -5.882632255554199, -0.2873288094997406, -0.1540701687335968, 0.4278307557106018, 0.24289260804653168, -0.2611287832260132, 1.0669784545898438, 0.310721755027771, 0.28895407915115356, 0.019719935953617096, 0.26849398016929626, -0.03445767983794212, -0.00033922246075235307, -0.2593400478363037, -0.2982911467552185, 0.15055865049362183, 0.5004897117614746, -0.04792344942688942, 0.2528797686100006, 0.274811714887619, 0.42621585726737976, -0.16375227272510529, -0.11249642819166183, 0.6236706972122192, -0.4268234372138977, -0.04364652559161186, -1.2051695585250854, 0.3133687973022461, -0.45308780670166016, -0.756290853023529, -0.44561392068862915, -0.6846790313720703, 0.18255706131458282, -0.5734615325927734, 0.3750484883785248, -0.48911237716674805, 0.032095637172460556, 0.09109741449356079, -0.31801602244377136, -0.11507540196180344, 0.4382062256336212, 0.2119264006614685, 0.21596960723400116, 0.008326527662575245, 0.49043717980384827, 0.009714372456073761, -0.2979448437690735, 0.017308587208390236, -0.33681541681289673, 0.7983580231666565, -0.1810237467288971, 0.2190544456243515, 0.6955354809761047, 0.6707147359848022, 0.571699857711792, 0.08145815879106522, 0.044986288994550705, 0.1615227907896042, -0.1504622995853424, 0.11227875202894211, -0.050290245562791824, -0.005831774789839983, 0.07423541694879532, -0.3978728652000427, -0.4804799556732178, 0.23298294842243195, -0.14704890549182892, -0.3500080108642578, 0.06539798527956009, 0.0746372640132904, -0.6086573600769043, 0.5575217008590698, 0.03630224987864494, -0.6127080917358398, 0.5521564483642578, 0.19416160881519318, 0.2542811930179596, 0.07663828879594803, 0.09640204906463623, 0.229385107755661, -0.28465327620506287, -0.0849132239818573, 0.49920833110809326, 0.06049695611000061, 0.058948442339897156, -0.28332698345184326, -0.2280711680650711, 0.1826360821723938, -0.1777760088443756, 0.5032320618629456, 0.5292429327964783, 0.25298187136650085, 0.4964660704135895, 0.05500861629843712, 0.3819476068019867, -0.3148106336593628, 0.3806573748588562, 0.6346585750579834, 0.3411862254142761, 0.24243809282779694, 0.7548559904098511, 0.012910517863929272, -0.5545462369918823, -0.5210292935371399, -0.16626493632793427, -0.39032307267189026, -0.2558668851852417, 0.28220266103744507, 0.5647236108779907, -0.8018147945404053, -0.1511203646659851, 0.5296359658241272, -0.44634512066841125, -0.2596556544303894, 0.4278145730495453, 0.17336411774158478, -0.014189664274454117, 0.08261856436729431, 0.5105948448181152, -0.13669712841510773, -0.1745552271604538, 0.5100340843200684, -0.5031386017799377, -0.2816838324069977, 0.5703654885292053, -0.5285280346870422, 0.1329387128353119, 0.16187213361263275, -0.1453009396791458, -0.3142707347869873, 0.16330468654632568, 0.2525455057621002, -0.7073354721069336, -0.6012325286865234, 0.3843111991882324, -0.4119909405708313, -0.22797410190105438, 0.5248036980628967, -0.21474187076091766, -0.4079257547855377, 0.0987347662448883, -0.33519265055656433, 0.007228015922009945, -0.012970097362995148, 0.4941074848175049, 0.31862637400627136, 0.21552005410194397, -0.06803159415721893, 0.3497149348258972, -0.05891461297869682, 0.17822998762130737, -0.2151855081319809, 0.6078110933303833, 0.06655459851026535, -0.29495713114738464, 0.07213666290044785, 0.6086703538894653, 0.1799621880054474, 0.05736193060874939, -0.8503427505493164, 0.4161163866519928, 0.06026254594326019, -0.7588368654251099, 0.3244316577911377, -0.15651258826255798, 0.01897628791630268, -0.3633936643600464, -0.27912527322769165, 0.09990568459033966, 0.3452260494232178, -0.13244420289993286, -0.10738690197467804, -0.05695681646466255, -0.24975331127643585, 0.12840530276298523, -0.3750200569629669, -0.08339337259531021, 0.033145271241664886, 0.1186695247888565, 0.05121799558401108, 0.19553202390670776, -0.21189624071121216, -0.21082115173339844, 0.5162016153335571, 0.2620525658130646, -0.17359016835689545, 0.045310620218515396, 0.32233962416648865, -0.2542523145675659, -0.255100280046463, -0.1360689103603363, -0.12338818609714508, 0.5602396726608276, -0.16332580149173737, 0.0614481121301651, -0.16142459213733673, 0.2569069266319275, 0.46011489629745483, 0.13077034056186676, -0.43168702721595764, 0.20704996585845947, 0.36493051052093506, -0.29490113258361816, 0.011062735691666603, 0.37350139021873474, 0.19016492366790771, -1.0398117303848267, -0.3062070608139038, 0.43904122710227966, -0.20123548805713654, -0.2807042598724365, -0.5525160431861877, 0.13308078050613403, 0.07939711213111877, -0.12138587236404419, -0.11837470531463623, 0.35368800163269043, -0.09226292371749878, -0.07252297550439835, 0.12392797321081161, 0.1780805140733719, -0.007164156064391136, -0.05636626482009888, 0.20373426377773285, -0.10471618920564651, 0.628584623336792, 0.3238542973995209, -0.4931938946247101, -0.08608726412057877, 0.31037285923957825, -0.04241522029042244, 0.19296909868717194, 0.021776877343654633, 0.3762901723384857, -0.3007558286190033, -0.061172906309366226, 0.0964013859629631, 0.4035661220550537, -0.47627541422843933, 0.7326030731201172, 0.4096929728984833, 0.38795867562294006, -0.18550482392311096, -0.18275068700313568, 0.01587541028857231, 0.26970577239990234, 0.40518614649772644, -0.2524340748786926, -0.5024208426475525, 0.11934828013181686, 0.2365736961364746, 0.12075352668762207, -0.02867477387189865, 0.2033727467060089, 0.7910619378089905, -0.07761263102293015, 0.062329381704330444, -0.22443342208862305, -0.029644623398780823, 0.1710907518863678, -0.23185047507286072, 0.4549279510974884, -0.2622717320919037, 0.04818982630968094, 0.48577478528022766, 0.08396204560995102, -0.6597926616668701, -0.4282850921154022, 0.6087652444839478, -0.4101351201534271, 0.0034003399778157473, 0.008245805278420448, 0.8290531635284424, 0.7851172089576721, 0.2880837619304657, 0.21108117699623108, -0.23513366281986237, -0.04345516487956047, -0.2823109030723572, -0.40493738651275635, -0.4872342646121979, -0.5906791687011719, 0.5155399441719055, -0.3973183333873749, 0.49622100591659546, -0.6294505596160889, -0.11586332321166992, -0.5234942436218262, -0.5394707322120667, -0.14981769025325775, -0.1099662184715271, 0.17864078283309937, -0.1950920969247818, -0.6468311548233032, -0.21850264072418213, 0.05862955376505852, 0.22750306129455566, 0.052261777222156525, 0.15097658336162567, 0.05427858233451843, -0.3854820132255554, 0.0422949381172657, 0.7260270118713379, -0.7117416262626648, -0.02903684601187706, 0.23797346651554108, 0.5390167236328125, 0.5033554434776306, -0.1552181988954544, -0.21879659593105316, 0.31573614478111267, -0.27988913655281067, -0.03256142511963844, 0.19015319645404816, -0.29443344473838806, 0.21443575620651245, -0.032689642161130905, -0.1648666262626648, 0.4551418125629425, 0.1793942153453827, 0.3419159948825836, 0.6374660134315491, -0.12223418802022934, 0.150906503200531, -0.0488147959113121, 0.31011930108070374, 0.2965134084224701, 0.08733493089675903, -0.07658687978982925, 0.565133273601532, 0.043364811688661575, 0.3461197316646576, -0.46591901779174805, 0.3280043303966522, -0.10646134614944458, 0.018691452220082283, 0.04165484383702278, -0.7055432200431824, 0.08237962424755096, 0.3993673026561737, 1.0520988702774048, 0.2907962203025818, -0.5083422660827637, -0.03211582824587822, 0.35893064737319946, 0.15569685399532318, 0.06894932687282562, -0.14231470227241516, -0.39033710956573486, 0.48842480778694153, 0.16182811558246613, -0.5138444900512695, -0.15716686844825745, 0.19651563465595245, -0.6513593792915344, 0.4789354205131531, 0.16488829255104065, -0.5760619640350342, -0.21572671830654144, 0.0410519614815712, -0.48681318759918213, 0.7329467535018921, -0.07614172995090485, 0.5632261037826538, -0.41687190532684326, 0.4006521701812744, 0.28912317752838135, -0.4384085237979889, 0.08932998776435852, -0.2028062492609024, 0.4642070233821869, -0.20708143711090088, -0.297960102558136, 0.1142568439245224, 0.4932602047920227, -0.054483573883771896, 0.6968382000923157, 0.3354073464870453, 0.016114944592118263, 0.26120805740356445, -0.29639753699302673, 0.1037759929895401, -0.13368180394172668, -0.30108657479286194, -0.2553185224533081, -0.437739759683609, -0.3731950521469116, -0.2714356482028961, 0.20845894515514374, 0.243550106883049, 0.1184411272406578, -0.9228524565696716, -0.07106997817754745, -0.003824508748948574, -0.19963784515857697, 0.21226494014263153, 0.04773089662194252, 0.3511207103729248, 0.07967377454042435, 0.14750158786773682, -0.15644808113574982, 0.33941760659217834, 0.15939131379127502, 0.609216034412384, -0.11210344731807709, 0.722162127494812, -0.37777724862098694, -0.2242867797613144, -0.16274788975715637, 0.0008946284651756287, 0.8226627707481384, -0.27876967191696167, -0.19616585969924927, 0.2091151922941208, 0.3767888844013214, -0.34857451915740967, 0.14303921163082123, -0.49471017718315125, -0.18612277507781982, -0.6268020272254944, 0.4874412715435028, -0.4579959213733673, 0.00602660933509469, 0.21183808147907257, -0.7094157934188843, 0.20324547588825226, 0.3126666247844696, 0.740696907043457, -0.3183720111846924, 0.690545916557312, -0.3506130874156952, 0.13898544013500214, -0.3267488479614258, 0.15613259375095367, -0.15056860446929932, 0.23997105658054352, -0.23849909007549286, 0.3114546239376068, -0.19035673141479492, 0.324245423078537, 0.1116514801979065, 0.29705068469047546, -0.16961586475372314, -0.1893814355134964, 0.0069509707391262054, 0.11473694443702698, 0.1673031598329544, -0.6121056079864502, -0.46414369344711304, 0.5084937214851379, 0.14580045640468597, -0.23607797920703888, -0.6928776502609253, 0.6365311741828918, -0.5426230430603027, -0.5775480270385742, 0.11130701750516891, -0.38604170083999634, 0.24249596893787384, 0.049655962735414505 ]
OBJECTIVE Impulsivity and inattention related to attention deficit hyperactivity disorder (ADHD) may increase food intake and, consequently, weight gain. However, findings on the association between obesity/overweight and ADHD are mixed. The authors conducted a meta-analysis to estimate this association. METHOD A broad range of databases was searched through Aug. 31, 2014. Unpublished studies were also obtained. Study quality was rated with the Newcastle-Ottawa Scale. Random-effects models were used. RESULTS Forty-two studies that included a total of 728,136 individuals (48,161 ADHD subjects; 679,975 comparison subjects) were retained. A significant association between obesity and ADHD was found for both children (odds ratio=1.20, 95% CI=1.05-1.37) and adults (odds ratio=1.55, 95% CI=1.32-1.81). The pooled prevalence of obesity was increased by about 70% in adults with ADHD (28.2%, 95% CI=22.8-34.4) compared with those without ADHD (16.4%, 95% CI=13.4-19.9), and by about 40% in children with ADHD (10.3%, 95% CI=7.9-13.3) compared with those without ADHD (7.4%, 95% CI=5.4-10.1). The significant association between ADHD and obesity remained when limited to studies 1) reporting odds ratios adjusted for possible confounding factors; 2) diagnosing ADHD by direct interview; and 3) using directly measured height and weight. Gender, study setting, study country, and study quality did not moderate the association between obesity and ADHD. ADHD was also significantly associated with overweight. Individuals medicated for ADHD were not at higher risk of obesity. CONCLUSIONS This study provides meta-analytic evidence for a significant association between ADHD and obesity/overweight. Further research should address possible underlying mechanisms and the long-term effects of ADHD treatments on weight in individuals with both ADHD and obesity.
[ -0.016183359548449516, 0.008195111528038979, -0.012845312245190144, 0.017757337540388107, 0.012829069048166275, -0.0017641339218243957, 0.006896987557411194, 0.002268514595925808, -0.00817149505019188, 0.003783418331295252, -0.0028676940128207207, 0.013603275641798973, -0.014469639398157597, 0.01035267487168312, -0.01773913763463497, 0.013194343075156212, -0.0017135613597929478, 0.013706367462873459, 0.00007497573096770793, 0.017731910571455956, -0.012433596886694431, -0.00934462808072567, 0.007838243618607521, 0.014885962009429932, -0.046626314520835876, 0.016768362373113632, 0.010209114290773869, -0.00454870518296957, 0.013561520725488663, -0.0004432210698723793, -0.016737213358283043, -0.010003853589296341, -0.002769964747130871, 0.01669570803642273, 0.0017101307166740298, 0.02322227880358696, -0.0018454031087458134, 0.009859975427389145, -0.020978257060050964, -0.004114530514925718, -0.0024736549239605665, 0.0000031503732316195965, 0.001985645852982998, -0.028331313282251358, -0.0063749379478394985, 0.015466490760445595, -0.0020946222357451916, -0.013040930032730103, -0.0181967094540596, 0.005735716316848993, -0.011923913843929768, -0.012689518742263317, -0.009749849326908588, 0.0008451538160443306, -0.004023379646241665, 0.02347104623913765, 0.014928915537893772, -0.01044408604502678, -0.03411039337515831, 0.020243719220161438, 0.019233886152505875, 0.024356704205274582, 0.002314645331352949, 0.005037128925323486, 0.013948420062661171, -0.06782881915569305, -0.009465544484555721, -0.009673332795500755, 0.008651225827634335, -0.0029398517217487097, 0.010700027458369732, 0.003237741068005562, 0.008461348712444305, 0.003356423694640398, -0.005840091500431299, 0.002805802971124649, 0.019865117967128754, -0.024895725771784782, 0.00799494981765747, 0.014948827214539051, -0.012872764840722084, 0.003671452635899186, -0.0137141402810812, 0.013700179755687714, -0.0005321579519659281, -0.020178761333227158, -0.014991087839007378, -0.003432147204875946, 0.010973992757499218, 0.02610507234930992, -0.0025454233400523663, -0.022870536893606186, 0.00863678753376007, 0.009040990844368935, -0.021827377378940582, -0.0008839527145028114, 0.0002558648120611906, 0.0025078547187149525, 0.017725447192788124, -0.011445147916674614, -0.003561165649443865, -0.00547410873696208, 0.018260734155774117, -0.015351271256804466, 0.019704537466168404, 0.007086793892085552, -0.010471148416399956, 0.031310152262449265, -0.00791233405470848, 0.007971270009875298, 0.003164705354720354, 0.004416660405695438, 0.005886668339371681, 0.010539378970861435, 0.02282676100730896, 0.0005292491987347603, -0.0004883818328380585, 0.00268898019567132, 0.0004995767958462238, -0.006738899275660515, 0.018680855631828308, -0.006144165992736816, -0.00003107672091573477, 0.007979566231369972, 0.0033439048565924168, 0.012714924290776253, 0.014761440455913544, 0.009166565723717213, -0.025149870663881302, 0.0009367284364998341, -0.003966870252043009, -0.0019815906416624784, 0.003465482033789158, 0.033610519021749496, -0.0035703089088201523, -0.00751997996121645, -0.004228622652590275, 0.0004746662452816963, -0.0008746546227484941, 0.006524571217596531, -0.001728489063680172, 0.00434955395758152, -0.00033178209559991956, 0.003217581892386079, 0.010325287468731403, 0.0024746437557041645, 0.0023116618394851685, -0.0007179446402005851, 0.007283256389200687, -0.02131916955113411, 0.02000347152352333, 0.004591369070112705, -0.016882872208952904, -0.01472010649740696, 0.006224550306797028, -0.0012736180797219276, -0.005932880565524101, -0.0022984021343290806, 0.003623356344178319, 0.00975276343524456, -0.02552386000752449, -0.015958435833454132, 0.0030065341852605343, 0.0072552855126559734, 0.004243454895913601, 0.0200666356831789, -0.014147399924695492, -0.0033146152272820473, 0.00006657186895608902, 0.002545430324971676, -0.005821547470986843, 0.004746783059090376, -0.018514424562454224, -0.0006134620634838939, -0.007717079017311335, -0.006347836926579475, -0.029955901205539703, 0.003953077830374241, 0.0006125338841229677, 0.0670405700802803, 0.013702016323804855, -0.008667131885886192, -0.020966261625289917, -0.020139174535870552, -0.0014072395861148834, -0.008698677644133568, 0.014507867395877838, -0.008374207653105259, 0.0030441205017268658, -0.010891644284129143, -0.002467865590006113, 0.01116923987865448, 0.03187091276049614, -0.0015197572065517306, 0.004277847707271576, 0.00306774047203362, 0.018550466746091843, -0.002499684691429138, 0.001906033605337143, -0.021908247843384743, -0.014129719696938992, -0.007699143141508102, 0.0015420118579640985, -0.006469143088907003, -0.0076924581080675125, 0.0027325060218572617, 0.0005065251607447863, -0.01088641956448555, 0.005910016596317291, -0.01295422948896885, 0.006135696545243263, 0.014015637338161469, 0.0020603197626769543, -0.0013022650964558125, 0.000958471093326807, -0.0038779317401349545, 0.0017882769461721182, 0.0017045466229319572, -0.010751458816230297, -0.013536643236875534, 0.000008225819328799844, 0.004138100892305374, 0.0022816266864538193, -0.01188258733600378, -0.007639237679541111, -0.011986012570559978, -0.0039815763011574745, 0.00703457510098815, -0.013430902734398842, 0.001971984514966607, 0.00018438673578202724, -0.007994149811565876, -0.0027970680966973305, -0.00472790002822876, 0.01337314024567604, -0.0030541736632585526, 0.009692316874861717, 0.01772100105881691, 0.011083393357694149, -0.0038710488006472588, 0.013262391090393066, -0.005314174108207226, 0.012398173101246357, 0.011649219319224358, 0.029678037390112877, 0.002581787994131446, -0.0022560018114745617, 0.005141627509146929, 0.005422291811555624, -0.0012592123821377754, 0.0011665341444313526, -0.008603375405073166, -0.02054464817047119, -0.010567070916295052, -0.02453242614865303, -0.016416503116488457, -0.009197741746902466, -0.010917113162577152, 0.022329475730657578, -0.01767413318157196, 0.007419215980917215, 0.0025856865104287863, 0.015696106478571892, 0.013365628197789192, -0.023229092359542847, -0.01569775491952896, 0.014702208340168, 0.015382560901343822, -0.000642245402559638, 0.031081072986125946, -0.00229805801063776, -0.006453429348766804, -0.011448638513684273, -0.08228561282157898, -0.011975781060755253, -0.005544570274651051, 0.0253332257270813, 0.0035108975134789944, 0.01167788915336132, 0.005120646208524704, 0.0039490461349487305, -0.011791061609983444, -0.006639593280851841, 0.010058492422103882, 0.00010138214565813541, -0.0040107714012265205, -0.018966834992170334, -0.020289288833737373, 0.0010099498322233558, 0.002294392790645361, -0.031133286654949188, 0.0011411367449909449, 0.011532948352396488, -0.00820522103458643, -0.018510252237319946, 0.0031433464027941227, 0.0005517358658835292, 0.022857487201690674, -0.012777821160852909, -0.0016739284619688988, -0.019533377140760422, 0.00547783775255084, 0.010940391570329666, 0.005343203898519278, -0.00595915038138628, -0.013671760447323322, -0.0038767163641750813, -0.01627427339553833, 0.0001738821156322956, -0.017308004200458527, -0.015770185738801956, -0.009335288777947426, -0.026570487767457962, 0.007332806475460529, -0.0062547717243433, 0.009830901399254799, 0.0034324578009545803, 0.014291482977569103, 0.008159264922142029, -0.020875781774520874, 0.0005250715184956789, 0.004170284140855074, 0.013493679463863373, -0.017812322825193405, -0.009034661576151848, 0.009870508685708046, 0.00387719739228487, -0.0029343755450099707, -0.03543572500348091, -0.0034778984263539314, -0.0145522840321064, -0.006378173828125, -0.008233784697949886, 0.01721874810755253, -0.030451610684394836, 0.0107328612357378, 0.0005185992922633886, -0.014447074383497238, 0.00046858383575454354, 0.002339079510420561, -0.0022692172788083553, -0.006746687460690737, -0.0026814418379217386, 0.012189696542918682, -0.005199599079787731, 0.005014443304389715, -0.008691756054759026, -0.0014111647615209222, -0.010851502418518066, -0.008625798858702183, -0.0020521203987300396, 0.001879900461062789, -0.007461892440915108, -0.00476221926510334, -0.008692434057593346, -0.0065588392317295074, -0.003923892509192228, -0.010539477691054344, 0.014851215295493603, 0.002262338763102889, 0.013391075655817986, 0.01881631277501583, -0.0064564356580376625, -0.007922405377030373, 0.011107503436505795, 0.011710988357663155, 0.008280014619231224, 0.019735516980290413, 0.009626463986933231, -0.006255083717405796, -0.01181701011955738, -0.007130436133593321, 0.005982959643006325, 0.014987995848059654, 0.012055667117238045, -0.006964114494621754, -0.006495233625173569, 0.01300282683223486, 0.010443276725709438, -0.000381466350518167, 0.012998606078326702, -0.001581456046551466, -0.006840807385742664, -0.019460702314972878, -0.032173871994018555, -0.003346789861097932, 0.022158104926347733, 0.0035328338854014874, -0.01188134029507637, -0.01687558926641941, -0.000595928868278861, 0.07365816086530685, 0.00737277464941144, 0.005203127861022949, -0.0016198004595935345, 0.01848536729812622, -0.006735777482390404, -0.02312391996383667, 0.021350031718611717, 0.016396155580878258, -0.022998947650194168, 0.009666703641414642, 0.001609510276466608, -0.0035032324958592653, 0.0058771176263689995, 0.017044801265001297, 0.011297179386019707, -0.0010867572855204344, 0.01553627010434866, -0.0068285055458545685, -0.011380873620510101, -0.024082735180854797, 0.013917957432568073, 0.0184552613645792, -0.022708486765623093, 0.01847251132130623, -0.021621638908982277, -0.024002810940146446, -0.014789811335504055, -0.009781294502317905, -0.0007297606207430363, 0.013453235849738121, 0.01243696641176939, -0.0027600335888564587, -0.011593839153647423, -0.025974025949835777, 0.0012491997331380844, 0.0015255879843607545, -0.018018295988440514, 0.01737208664417267, 0.007874857634305954, -0.013594678603112698, -0.011660374701023102, -0.0023109125904738903, 0.008479395881295204, -0.0347433015704155, -0.008285915479063988, 0.011578518897294998, -0.0028131764847785234, -0.013719545677304268, 0.01756545901298523, 0.006797351408749819, 0.003179771825671196, 0.005257060751318932, 0.02638670802116394, 0.01094895415008068, -0.007189152762293816, -0.00960402749478817, -0.0015387870371341705, -0.006128671579062939, -0.027425602078437805, 0.004646915942430496, -0.01833111047744751, 0.020029408857226372, 0.005990856327116489, -0.02178642526268959, -0.01557078305631876, 0.004200098570436239, -0.0031291311606764793, 0.005958626512438059, 0.009038340300321579, 0.004701731260865927, -0.01910139061510563, -0.0010696290992200375, -0.01625891774892807, -0.014311591163277626, 0.0010440985206514597, -0.02498362585902214, -0.01461117248982191, -0.0031205001287162304, -0.005429173819720745, -0.008718013763427734, -0.017658207565546036, -0.0202629454433918, -0.006526125594973564, -0.002663898514583707, 0.025057870894670486, 0.00869838148355484, -0.07574093341827393, 0.005649776663631201, 0.003023993456736207, -0.006181460339576006, 0.008351791650056839, 0.009847486391663551, -0.009338002651929855, -0.00006913766264915466, -0.005915007088333368, 0.000507585471495986, 0.01880466751754284, -0.012619833461940289, -0.0012856125831604004, -0.004643548280000687, 0.00804572831839323, -0.015132826752960682, -0.006363172084093094, 0.0017044090200215578, 0.0011877479264512658, 0.0001981412060558796, -0.006741619668900967, 0.0017910059541463852, -0.02331102266907692, -0.011684847995638847, 0.01009196974337101, -0.0825158953666687, 0.0015855920501053333, -0.005616216920316219, -0.007796917110681534, -0.006576349958777428, 0.010352990590035915, 0.004221091978251934, -0.00970379263162613, 0.006706424057483673, -0.01357913576066494, 0.006521900184452534, -0.008142594248056412, 0.02504340186715126, -0.009614415466785431, 0.005535091273486614, -0.002463279291987419, -0.006629219278693199, 0.0162693839520216, 0.006002710200846195, 0.004107726737856865, 0.009684789925813675, 0.014915735460817814, -0.00285183172672987, 0.0029838867485523224, -0.005026585888117552, 0.016512691974639893, -0.019331738352775574, 0.004813435487449169, 0.031999371945858, -0.008678259328007698, -0.0030682412907481194, 0.0008236635476350784, -0.01940121129155159, 0.009753487072885036, -0.006729466840624809, -0.014665964990854263, -0.004181987605988979, -0.012245760299265385, 0.03087451122701168, -0.012936389073729515, 0.0031274068169295788, -0.0061137620359659195, 0.00033777032513171434, 0.011415901593863964, 0.009822252206504345, -0.00462630670517683, 0.0029971585609018803, -0.006418402306735516, -0.00004462338984012604, -0.012971129268407822, 0.009953233413398266, 0.00451053399592638, 0.009837212972342968, -0.008045819588005543, -0.01824128068983555, 0.0033733504824340343, -0.0035037188790738583, 0.029763905331492424, -0.008868975564837456, -0.00013399936142377555, 0.006007944233715534, 0.009519487619400024, 0.008325371891260147, 0.07246249914169312, -0.0025776829570531845, 0.00427539087831974, 0.001749558374285698, -0.0046844566240906715, -0.002616514917463064, 0.010705696418881416, 0.0030382066033780575, 0.0234884861856699, -0.006502866744995117, -0.01191097404807806, -0.013600612059235573, -0.018108908087015152, 0.0012880965368822217, 0.00460913497954607, 0.014532447792589664, 0.0005313388537615538, -0.006587959360331297, -0.0018201072234660387, -0.002462745178490877, -0.03634098917245865, 0.004131773952394724, -0.03366357833147049, 0.017399970442056656, 0.02174346148967743, -0.0014060852117836475, 0.0032972213812172413, 0.01847447082400322, 0.004582962952554226, 0.014949465170502663, -0.001039999071508646, 0.004697177559137344, 0.0008983933366835117, -0.02067418582737446, -0.003563801757991314, 0.020271167159080505, 0.010895065031945705, 0.001496797427535057, -0.03840334713459015, -0.005443247966468334, 0.02230685204267502, 0.014970106072723866, 0.0005994366947561502, 0.019526205956935883, 0.0018887524493038654, 0.009574513882398605, -0.0034566097892820835, -0.02000456117093563, -0.03397981449961662, 0.0059255813248455524, -0.022284436970949173, -0.003382038092240691, -0.020984522998332977, 0.009116087108850479, -0.001687828917056322, 0.013536066748201847, -0.009677298367023468, 0.009256511926651001, -0.016523247584700584, -0.008925827220082283, -0.02000105008482933, -0.011883318424224854, 0.008645967580378056, -0.012906892225146294, 0.013381335884332657, 0.015937436372041702, 0.004073321353644133, -0.007624520920217037, -0.02676173485815525, 0.007768665440380573, -0.005842606537044048, -0.007455986924469471, 0.0004539768269751221, 0.012476621195673943, 0.01181011088192463, 0.006494889035820961, 0.0087129520252347, -0.01209278218448162, 0.003284251783043146, 0.0017000865191221237, -0.01034504547715187, 0.003434622660279274, -0.014842839911580086, 0.008725209161639214, 0.007645038887858391, 0.006966129876673222, 0.028287872672080994, -0.0023901760578155518, -0.001219439902342856, 0.002995849587023258, -0.02296285331249237, -0.007651899475604296, -0.0005988671910017729, 0.023845095187425613, 0.003743823617696762, 0.03289446234703064, 0.0077947103418409824, 0.0018161238403990865, -0.004834373947232962, 0.001206589862704277, -0.016044579446315765, 0.014008628204464912, 0.014089548960328102, 0.007977299392223358, 0.0009586390806362033, 0.005466246046125889, 0.014936789870262146, -0.014785953797399998, 0.027687963098287582, -0.002311880001798272, -0.016942113637924194, -0.004432159475982189, 0.003662906587123871, 0.012363292276859283, 0.0031884005293250084, 0.014436615630984306, -0.008963676169514656, -0.017348816618323326, 0.017712954431772232, -0.007152549922466278, -0.011714616790413857, -0.012470761314034462, 0.012962205335497856, -0.011610126122832298, 0.02183179184794426, -0.010868924669921398, -0.00970002356916666, 0.000276762992143631, 0.013715102337300777, 0.021678615361452103, 0.0032191448844969273, 0.004366418346762657, 0.014126301743090153, 0.007439109031111002, 0.0014533991925418377, -0.013389448635280132, 0.019533071666955948, -0.010051656514406204, -0.00017025985289365053, 0.029749508947134018, -0.012136347591876984, 0.0012399984989315271, -0.0028037307783961296, 0.0109141506254673, 0.0065282718278467655, 0.0018326970748603344, 0.008312053978443146, 0.013922672718763351, 0.01316686999052763, -0.0100646847859025, 0.007434435188770294, -0.007577902637422085, -0.007274084724485874, -0.0013914790470153093, -0.004010894801467657, 0.008757689036428928, 0.0017186935292556882, 0.01680237054824829, -0.008056940510869026, -0.027509726583957672, -0.0018358074594289064, -0.01521342247724533, -0.010689201764762402, 0.008470479398965836, -0.004220298025757074, 0.0035136165097355843, -0.00353695685043931, 0.022807586938142776, -0.007173637393862009, 0.017321251332759857, 0.025217007845640182, -0.006863459479063749, -0.015988171100616455, 0.017010850831866264, -0.019099367782473564, -0.0016313588712364435, -0.0019965937826782465, 0.009053644724190235, -0.007897874340415001, 0.00707806833088398, 0.005741504020988941, -0.009188308380544186, -0.014922522939741611, -0.007247282657772303, -0.0009177615866065025, 0.012600904330611229, 0.001118539134040475, -0.004812810104340315, 0.008706708438694477, 0.01358129270374775, -0.0050929333083331585, -0.014446989633142948, -0.0022723632864654064, -0.008788864128291607, -0.004720513708889484, -0.009546594694256783, -0.008000273257493973, 0.007465490140020847, -0.009711842983961105, -0.010343030095100403, -0.010803031735122204, -0.0014643664471805096 ]
[ 0.24354508519172668, 0.22352196276187897, 0.1829741895198822, 0.25980350375175476, -0.46523091197013855, 0.6454373598098755, 0.6594672203063965, -0.1158389076590538, 0.05137452855706215, 0.04171052947640419, 0.34174680709838867, 0.6444100737571716, -0.23390023410320282, -0.18823544681072235, 0.07923583686351776, 0.5426369309425354, 0.6485282182693481, 0.3968929648399353, -0.25802257657051086, -0.28991982340812683, -0.12751588225364685, -0.7092967629432678, 0.6010415554046631, -0.10405472666025162, 0.08444628864526749, 0.4101395905017853, 0.5628619194030762, -0.10432221740484238, -0.13456666469573975, -0.25039106607437134, -0.18550728261470795, 0.9475314617156982, 0.0017484809504821897, 0.07308337092399597, 0.16326488554477692, 0.4408804178237915, 0.3814646601676941, 0.21556606888771057, 0.06977140158414841, -0.2524120509624481, 0.15860654413700104, -0.08072834461927414, -0.4600188136100769, 0.263174831867218, -0.6327037811279297, -0.6392949819564819, -1.3060194253921509, 0.5309872627258301, -0.417596697807312, 0.14518089592456818, 0.047184113413095474, 0.6450748443603516, 0.5166828036308289, 0.29632025957107544, -0.04239087179303169, 0.6006974577903748, -0.4336150586605072, -0.32274383306503296, 0.013476978987455368, -0.16910314559936523, 0.2792712450027466, 0.04637611657381058, 0.1829230934381485, -0.05497376248240471, -0.2965717017650604, 0.1706547737121582, -0.026337798684835434, 0.3919496238231659, -0.17738927900791168, -0.10327651351690292, -0.3959810435771942, -0.6900187134742737, -0.43589937686920166, 0.4940473139286041, -0.28520017862319946, 0.003072405466809869, -0.12233982980251312, 0.02951773814857006, 0.3565549850463867, -0.36083564162254333, 0.3978968560695648, 0.18529514968395233, 0.2866169810295105, -0.5150735378265381, -0.00919392891228199, 0.1691151261329651, 0.31157365441322327, 0.4548480212688446, 0.015559426508843899, 0.09727960079908371, 0.1634477823972702, -0.05415055900812149, 0.6306359171867371, 0.6370421648025513, 0.08075600862503052, 0.14510175585746765, 0.3632323443889618, -0.35405686497688293, 0.31071174144744873, 0.046690359711647034, 0.18124227225780487, -0.04256470873951912, 0.18976426124572754, 0.3076658844947815, -0.4656808376312256, 0.2316371351480484, 0.23765602707862854, -0.7727240920066833, -0.38820308446884155, 0.009072279557585716, -1.0069143772125244, 0.5586733818054199, -0.45861533284187317, -0.25408443808555603, -0.35379576683044434, 0.04427561163902283, 0.09440182894468307, -0.11567874252796173, -0.10903751850128174, 0.2750622034072876, -0.4023676812648773, 0.3412165939807892, -0.19842177629470825, -0.11068981140851974, 0.01947450451552868, 0.03965085744857788, 0.26970574259757996, 0.2460569590330124, 0.1364475041627884, 0.9478073120117188, 0.05175981670618057, 0.19238129258155823, 0.012980624102056026, 0.12935009598731995, 0.058552756905555725, -0.5173319578170776, 0.25549939274787903, 0.06369306892156601, -0.03320055082440376, -0.16610944271087646, -0.2637198567390442, -0.6960051655769348, -0.48784440755844116, -0.06228753924369812, 0.192786306142807, -0.3722420930862427, 0.20723168551921844, 0.36802783608436584, -0.36655357480049133, -0.08354779332876205, 0.07354441285133362, 0.04756921902298927, -0.514474630355835, -0.6187535524368286, 0.6948809027671814, 0.13366807997226715, -0.7379374504089355, -0.2619553208351135, -0.25753337144851685, -0.11227989941835403, 0.38449087738990784, 0.42695122957229614, -0.6593272686004639, -0.21120581030845642, 0.38200753927230835, -0.3461121618747711, -0.18746665120124817, 0.3320004642009735, -0.09694266319274902, 0.35626670718193054, -0.22828589379787445, -0.23435552418231964, 0.10862468928098679, 0.024331191554665565, -0.472933292388916, 0.3519723415374756, 0.4823228418827057, 0.22768528759479523, -0.015867063775658607, 0.45148274302482605, -0.6707928776741028, 0.03023281693458557, 0.33597326278686523, -0.3768264353275299, 0.1873127818107605, -0.028363177552819252, 0.7404809594154358, 0.06379199773073196, 0.014198420569300652, -0.03826664015650749, -0.15303026139736176, -0.2971155047416687, 0.5169638395309448, -0.6921811699867249, 1.5671480894088745, -0.33302491903305054, -0.46972769498825073, 0.7728303074836731, 0.08664902299642563, -0.11455973982810974, 0.08172555267810822, -0.29059433937072754, 0.6772633194923401, -0.15063953399658203, -0.8082161545753479, 0.07241831719875336, -0.21047279238700867, -0.2976810932159424, -0.6782886981964111, 0.3909200131893158, 0.16685478389263153, -0.30254894495010376, -0.32890596985816956, -0.1487407237291336, -0.32412004470825195, 0.2980839014053345, 0.06453301012516022, 0.5456629991531372, 0.12212959676980972, -0.455650269985199, 0.6942901015281677, -0.5081653594970703, 0.22181221842765808, 0.19118662178516388, -0.36811530590057373, 0.4967711269855499, 0.855527400970459, -0.0009911964880302548, 0.6726741790771484, -0.849351704120636, 0.36354219913482666, 0.060407087206840515, 0.7722944617271423, -0.05882817506790161, -0.04850906878709793, 0.43221354484558105, 0.2807234823703766, -0.22572454810142517, 0.8422574400901794, -0.19492483139038086, -0.16265998780727386, 0.2353598028421402, -0.31980371475219727, 0.35919755697250366, -0.12895497679710388, -0.2682436406612396, -0.34887370467185974, 0.7140783667564392, -1.1301217079162598, 0.17097985744476318, 0.3383128046989441, 0.12029044330120087, 0.10080532729625702, 0.06842812895774841, 0.2501198649406433, 0.020942863076925278, 0.06429100781679153, -0.7614278197288513, 0.4336414933204651, -0.14805057644844055, -0.2872714698314667, -0.041253525763750076, 0.3330918252468109, -0.2324860394001007, 0.5241074562072754, -0.42801615595817566, -0.7665985226631165, -0.5970130562782288, 0.2073119729757309, 0.3794024586677551, 0.8510399460792542, -0.0010094904573634267, -0.844288170337677, 0.6295080780982971, 0.15636737644672394, -0.25961771607398987, 0.18245592713356018, 0.5733792185783386, -0.720118522644043, -0.3558294475078583, 0.13089843094348907, 0.408443421125412, 0.4422479569911957, 0.012033449485898018, 0.05951889231801033, -0.5819492340087891, -0.18385490775108337, -0.5164843201637268, -0.49917805194854736, -0.3795648515224457, -0.03215617686510086, 0.805819034576416, -0.33051255345344543, -0.7812564969062805, 0.39526793360710144, 0.45214369893074036, 0.12012036889791489, 0.4761878252029419, 0.831104576587677, 0.07409428805112839, 0.3544279932975769, 0.06124572828412056, -0.023855391889810562, 0.011592477560043335, -0.020446771755814552, -0.3980291783809662, -0.12238730490207672, -0.10107453912496567, -6.012709140777588, 0.06306814402341843, -0.8256309032440186, -0.0887928456068039, -0.841843843460083, 0.004170096945017576, 0.7047331929206848, -0.16381953656673431, -0.2541120946407318, 0.25819048285484314, 0.5057573914527893, 0.08812577277421951, 0.24907764792442322, 0.3864915370941162, 0.26303592324256897, 0.4445047974586487, 0.4829411804676056, -0.23131521046161652, 0.309460312128067, 0.7654629349708557, 0.299452006816864, -0.39379581809043884, -0.10751569271087646, 0.3348355293273926, 0.5547752380371094, 0.40759339928627014, -0.4206780195236206, 0.44094541668891907, 0.06426569819450378, -0.37049564719200134, 0.5972998738288879, -0.745079517364502, -0.25695616006851196, -0.5171291828155518, 0.2869064211845398, 0.3946973383426666, 0.3716652989387512, -0.03862573578953743, 0.004957801662385464, -0.3903483748435974, -0.14204062521457672, 0.1409311145544052, 0.19147087633609772, -0.22473852336406708, 0.5069546699523926, -0.03764433041214943, -0.09779661148786545, 0.18920816481113434, -0.4433072805404663, -0.07665436714887619, 0.44819581508636475, 0.19833017885684967, -0.41599032282829285, 0.6371749043464661, -0.02842959761619568, 0.2117055356502533, 0.08374492824077606, 0.5760473012924194, -0.46622586250305176, 0.7406249642372131, 0.1532638818025589, 0.11088255047798157, -0.6118829250335693, -0.3181479275226593, -0.37291812896728516, 0.17255337536334991, -0.17309975624084473, -0.26314303278923035, 0.2530796527862549, 0.09804084897041321, -0.3519868552684784, -0.27538883686065674, 0.25347793102264404, -0.5560816526412964, 0.045479174703359604, -0.3405763506889343, 0.4603394865989685, 0.4048019349575043, -0.1680310070514679, 0.052874356508255005, -0.482444703578949, -0.45568251609802246, 0.18531522154808044, 0.15813906490802765, 0.2275337129831314, -0.1554097682237625, -0.13026010990142822, 0.41899290680885315, -0.14498387277126312, -0.009416834451258183, 0.16009557247161865, -0.4527228772640228, -0.00811005663126707, 0.33655279874801636, 0.22151057422161102, 0.2788604497909546, 0.5800834894180298, 0.2855604290962219, 0.6743351221084595, -0.13574530184268951, 0.1961844116449356, -0.008183284662663937, 0.24778664112091064, -0.7692605257034302, -0.16136391460895538, -0.044338781386613846, -0.4938611686229706, -0.18165770173072815, 0.9154652953147888, -0.916222333908081, 0.0126583781093359, 0.1265258640050888, -0.2920818626880646, -0.07247292250394821, 0.6446624398231506, -0.07892114669084549, -0.1354759782552719, -0.07855480909347534, 0.5359621644020081, -0.03467659652233124, -0.22581690549850464, 0.1640392541885376, -0.45704424381256104, -0.2407417893409729, -0.6355886459350586, -0.32832881808280945, 0.06524043530225754, 0.4423285126686096, -1.0366722345352173, 0.22661300003528595, 0.21697716414928436, 0.5245727896690369, -0.35278555750846863, 0.08680418878793716, 0.044934846460819244, -0.46493983268737793, 0.09393101185560226, 0.525711715221405, 0.2663829028606415, -0.2559835910797119, 0.4780673682689667, 0.05104789510369301, -0.2537612020969391, 0.11378104239702225, 0.1873277872800827, -0.08748693764209747, -0.03495819494128227, -0.5503950715065002, -0.22849106788635254, -0.11259790509939194, 0.21746686100959778, -0.051509466022253036, 0.005533058196306229, 0.21629977226257324, -0.131434828042984, 0.056982170790433884, 0.4314362406730652, 0.11505211144685745, -0.33333611488342285, -0.8107638955116272, 0.4664778411388397, -0.09601527452468872, -1.0708534717559814, -0.46693459153175354, 0.1307729184627533, -0.24604874849319458, -0.16431674361228943, -0.36037737131118774, 0.4523886740207672, 0.3101368248462677, 0.3319645822048187, -0.6642423272132874, -0.06792371720075607, -0.23666930198669434, -0.06609027087688446, -0.1741480678319931, -0.4252842664718628, -0.4827314019203186, -0.24358214437961578, 0.07641656696796417, -0.05193530023097992, -0.3261003792285919, -0.3679118752479553, 0.0780428871512413, 0.5481846928596497, 0.3582034111022949, 0.02680547721683979, 0.2291105091571808, -0.008810348808765411, -0.1083235964179039, -0.07070547342300415, -0.3799706995487213, 0.4035502076148987, -0.18470890820026398, -0.15072812139987946, -0.3107994794845581, 0.18560755252838135, 0.05061184614896774, -0.3888511657714844, 0.09210550785064697, -0.19248007237911224, 0.06637665629386902, -0.07854681462049484, 0.013120821677148342, 0.24848388135433197, -0.4771139323711395, -0.459725022315979, -0.3196284770965576, -0.3505176901817322, -0.17007963359355927, -0.5699490904808044, -0.3805685043334961, -0.47635170817375183, 0.22984525561332703, -0.06791095435619354, 0.48376983404159546, -0.24631428718566895, -0.2981058955192566, -0.30312663316726685, 0.0669422447681427, 0.504086434841156, -0.12086857110261917, -0.4996689260005951, -0.11315282434225082, -0.038837820291519165, -0.07585776597261429, 0.7596458792686462, -1.0589568614959717, 0.1619834303855896, -0.026357153430581093, -0.5615560412406921, 0.43719208240509033, 0.04775933548808098, 0.5695486664772034, -0.42685168981552124, 0.18736648559570312, -0.25703057646751404, 0.4295026361942291, 0.1206643208861351, 0.21054862439632416, -0.19271139800548553, 0.6563611030578613, -0.025624092668294907, 0.13978475332260132, 0.28248023986816406, 0.4391813576221466, -0.04303407669067383, -0.34295088052749634, -0.5265316367149353, -0.12201797962188721, -0.4255443215370178, -0.4491576850414276, 0.09717464447021484, -0.03797220066189766, 0.6590582132339478, -0.10802778601646423, 0.3265519142150879, -0.6208364963531494, 0.14534233510494232, 0.055489640682935715, -0.027257781475782394, -0.3094126284122467, -0.052784401923418045, 0.22003436088562012, -0.13534992933273315, 0.05770713463425636, -0.013319029472768307, -0.35467424988746643, 0.2901630401611328, -0.14491498470306396, 0.4720621109008789, 0.080913245677948, 0.0063299150206148624, 0.5672681331634521, -0.030518990010023117, -0.12909691035747528, -0.41682398319244385, 0.04897937551140785, 0.09808476269245148, 0.02423636056482792, -0.2159680426120758, -0.3176993429660797, 0.15134744346141815, -0.45192110538482666, -0.1368127167224884, -0.27672189474105835, 0.2161148190498352, 0.021804865449666977, -0.7430952787399292, -0.3660314083099365, -0.037502650171518326, 0.03833531588315964, -0.47058090567588806, -0.8575937151908875, -0.09478870034217834, 0.22519847750663757, -0.03964565321803093, 0.24406693875789642, -0.16836072504520416, -0.39938297867774963, -0.3582196831703186, 0.48561030626296997, 0.33318963646888733, -0.5658995509147644, -0.23678745329380035, 0.07735545933246613, 0.18072347342967987, -0.4433457553386688, 0.18947453796863556, -0.3303646147251129, 0.4679601192474365, 0.1864427924156189, 0.534008264541626, 0.4491995871067047, -0.5294773578643799, -0.18161128461360931, -0.33720362186431885, -0.03475087881088257, 0.4440079629421234, 0.736659049987793, -0.31519615650177, 0.4098298251628876, 0.7672635316848755, 0.0972113236784935, -0.07023877650499344, 0.030068054795265198, 0.22713744640350342, 0.4514470398426056, 0.3036845326423645, 0.7906231880187988, 0.15872472524642944, 0.18765276670455933, -0.23232236504554749, 0.7652688026428223, 0.13375431299209595, -0.14726047217845917, 0.0352947935461998, -0.43721723556518555, -0.22635334730148315, 0.08332090079784393, 1.087299108505249, 0.1866290271282196, -0.07942597568035126, 0.03161773085594177, -0.3389650583267212, 0.5985720753669739, -0.2511003017425537, 0.22837358713150024, -0.3127483129501343, 0.15584246814250946, 0.09987521916627884, 0.09123833477497101, -0.09976048767566681, -0.14592847228050232, -0.790751576423645, 0.09505188465118408, 0.07516634464263916, -0.25697794556617737, -0.8797062635421753, 0.18820427358150482, -0.10049456357955933, 0.20914947986602783, -0.04273204132914543, 0.06964714825153351, -0.31092569231987, -0.05920124426484108, 0.1511939913034439, 0.3481970727443695, -0.07072138041257858, 0.08251198381185532, -0.19686099886894226, 0.024776440113782883, -0.32994914054870605, 0.028996802866458893, 0.07350612431764603, -0.005292873829603195, 0.2017623484134674, 0.098480723798275, 0.24267837405204773, 0.09751953184604645, 0.0569479763507843, -0.020262138918042183, 0.10929796099662781, -0.3030124008655548, -0.15569089353084564, -0.010624253191053867, -0.07178104668855667, 0.430936723947525, 0.10713623464107513, -0.20796296000480652, 0.08318590372800827, -0.3178389072418213, 0.3177519142627716, 0.18556943535804749, -0.2487662136554718, -0.5097458362579346, -0.28721824288368225, 0.01905636116862297, 0.334200382232666, -0.05746733769774437, -0.0017774376319721341, -0.09999265521764755, -0.3010605573654175, 0.3774729073047638, -0.3536483645439148, 0.5439183712005615, -0.2994094789028168, 0.04809918999671936, -0.6627647876739502, -0.4734307527542114, 0.5676252841949463, -0.0990636870265007, -0.3117761015892029, -0.12958772480487823, -0.022864218801259995, 0.046407803893089294, 0.25509780645370483, -0.21293966472148895, -0.4057762622833252, -0.25216829776763916, -0.23773238062858582, -0.027781357988715172, 0.22856087982654572, -0.1918109655380249, -0.2520793080329895, 0.21196429431438446, 0.3923095166683197, -0.07334782183170319, -0.02679475210607052, 0.23752352595329285, -0.46780213713645935, -0.18357834219932556, -0.3401229977607727, 0.4054592549800873, -0.3959425687789917, 0.12221334874629974, 0.6266046762466431, -0.13948984444141388, 0.027793075889348984, -0.10230302065610886, -0.2902736961841583, -0.41759514808654785, 0.03424816578626633, -0.13949672877788544, 0.3452339768409729, 0.7528649568557739, 0.16744017601013184, -0.4225357174873352, -0.2692531943321228, 0.4651642143726349, -0.36997124552726746, -0.15102487802505493, -0.4355640113353729, -0.0722426101565361, -0.33541110157966614, 0.12966778874397278, 0.277328222990036, -0.5596383213996887, -0.21303267776966095, -0.34172511100769043 ]
Research on the human microbiome has established that commensal and pathogenic bacteria can influence obesity, cancer, and autoimmunity through mechanisms mostly unknown. We found that a component of bacterial biofilms, the amyloid protein curli, irreversibly formed fibers with bacterial DNA during biofilm formation. This interaction accelerated amyloid polymerization and created potent immunogenic complexes that activated immune cells, including dendritic cells, to produce cytokines such as type I interferons, which are pathogenic in systemic lupus erythematosus (SLE). When given systemically, curli-DNA composites triggered immune activation and production of autoantibodies in lupus-prone and wild-type mice. We also found that the infection of lupus-prone mice with curli-producing bacteria triggered higher autoantibody titers compared to curli-deficient bacteria. These data provide a mechanism by which the microbiome and biofilm-producing enteric infections may contribute to the progression of SLE and point to a potential molecular target for treatment of autoimmunity.
[ -0.01741546392440796, 0.016499998047947884, -0.017488552257418633, 0.008115051314234734, -0.0015098825097084045, -0.0027629192918539047, 0.011762769892811775, 0.029480740427970886, -0.009367795661091805, -0.004808948375284672, -0.004029775969684124, 0.012300576083362103, -0.0008237059228122234, 0.006142958998680115, 0.017845917493104935, -0.01638450101017952, 0.005185703281313181, -0.013750900514423847, 0.011766420677304268, 0.0053751179948449135, 0.035035401582717896, -0.01935243234038353, 0.010886289179325104, -0.01602136716246605, 0.007396357133984566, -0.0033369576558470726, 0.02658616006374359, -0.012789523229002953, -0.011122120544314384, 0.006866212468594313, 0.0014479956589639187, -0.016018591821193695, 0.020901301875710487, -0.01724965125322342, -0.011793863028287888, -0.016315795481204987, 0.000837547006085515, 0.026779692620038986, 0.025549277663230896, -0.003961854614317417, 0.009598350152373314, -0.015702445060014725, 0.008238358423113823, -0.0016239664983004332, -0.0069475420750677586, -0.017891280353069305, -0.001005183206871152, 0.001194387674331665, 0.004107186570763588, 0.005269559100270271, -0.013342439197003841, -0.031766559928655624, -0.011602893471717834, 0.014181505888700485, -0.0072405063547194, -0.016660459339618683, 0.020700428634881973, -0.03512345626950264, -0.008457403630018234, 0.02070481702685356, 0.009499724954366684, -0.031315505504608154, 0.0303313247859478, -0.04628570377826691, 0.02069542557001114, -0.06683184951543808, 0.020269112661480904, 0.005634576082229614, 0.005942766088992357, -0.010664524510502815, -0.013819580897688866, 0.009199948981404305, 0.00435652956366539, -0.0018284711986780167, -0.0038859667256474495, -0.014529373496770859, 0.006953530479222536, 0.02161480486392975, 0.027103427797555923, 0.009956625290215015, -0.03211302310228348, -0.009095467627048492, 0.005136384628713131, 0.027732037007808685, 0.00032557290978729725, 0.03699343651533127, -0.028706111013889313, 0.01332166325300932, -0.016571860760450363, -0.002284854184836149, 0.020915841683745384, 0.007768243085592985, -0.01884417235851288, -0.0062208413146436214, 0.010066873393952847, 0.010310158133506775, -0.008782822638750076, -0.002174480352550745, 0.02397279255092144, -0.005667281337082386, -0.026154618710279465, 0.010291785933077335, 0.012679968029260635, -0.01073282491415739, 0.019300730898976326, 0.008628380484879017, 0.004050755873322487, 0.03339872136712074, 0.03541402146220207, 0.012793703004717827, 0.013096543028950691, -0.004406757187098265, 0.03569730743765831, 0.025620482861995697, -0.0068529387935996056, -0.018746165558695793, 0.00026813987642526627, -0.013012917712330818, 0.006481585092842579, -0.01418672502040863, 0.035181932151317596, 0.011801529675722122, -0.0018630493432283401, 0.014162465929985046, 0.0013140413211658597, -0.0175815150141716, 0.002770310267806053, -0.02189011685550213, 0.03344999998807907, -0.0024218016769737005, -0.008146649226546288, 0.0017224454786628485, -0.013820964843034744, -0.006841715890914202, -0.0323750302195549, -0.001769106020219624, -0.02210959792137146, -0.016092650592327118, -0.0003100791946053505, -0.010403110645711422, -0.0008497836533933878, 0.004911104682832956, 0.00010055711027234793, 0.016400422900915146, 0.016198186203837395, -0.0014888099394738674, -0.02184295281767845, -0.009216264821588993, 0.03661500662565231, -0.0019349043723195791, -0.010700752027332783, 0.027144834399223328, -0.012144461274147034, -0.00843542255461216, -0.0007581808604300022, 0.014968009665608406, -0.007268570363521576, -0.006374050863087177, 0.00394101720303297, -0.006821474060416222, 0.023985400795936584, -0.025504549965262413, 0.005193077959120274, 0.010317554697394371, 0.010697510093450546, -0.0019034553552046418, 0.00994095765054226, -0.008038317784667015, 0.015581406652927399, 0.008688729256391525, -0.005985317286103964, 0.006069388706237078, 0.003468092530965805, 0.008341837674379349, -0.0018019983544945717, 0.0044579170644283295, 0.02695445343852043, 0.006770784966647625, -0.023808881640434265, 0.06634700298309326, 0.009749689139425755, 0.013813406229019165, 0.006330416072160006, -0.01676858402788639, 0.0042813802137970924, 0.0067942324094474316, 0.001626460230909288, -0.014099659398198128, -0.004931234288960695, 0.0025042223278433084, -0.006781003437936306, -0.008162264712154865, 0.005587638355791569, 0.0074707865715026855, 0.0002247598022222519, 0.004423995967954397, 0.00607310002669692, 0.0014561403077095747, 0.013444548472762108, -0.001962069422006607, 0.01861676014959812, -0.02041013166308403, 0.015427964739501476, 0.01058571320027113, -0.023706942796707153, -0.0075218938291072845, 0.002807528944686055, -0.007018797565251589, -0.0031158733181655407, -0.01020873337984085, 0.012186474166810513, -0.023464392870664597, -0.018083516508340836, -0.013633595779538155, -0.023907586932182312, -0.013419631868600845, -0.008601704612374306, -0.01268099993467331, 0.0009146331576630473, -0.009163732640445232, 0.0023665919434279203, 0.037824228405952454, -0.03628549352288246, -0.015006592497229576, 0.009270971640944481, 0.019575083628296852, -0.011002089828252792, 0.00870472751557827, 0.0008436092175543308, 0.009119992144405842, 0.019579458981752396, -0.017914434894919395, -0.011380833573639393, -0.034099481999874115, 0.0002960765268653631, -0.006412654183804989, 0.014773895032703876, -0.002760030794888735, 0.00287434458732605, -0.011227350682020187, 0.006306074559688568, -0.004909852519631386, -0.00025467900559306145, -0.018354244530200958, -0.014139334671199322, -0.020420348271727562, -0.010489820502698421, -0.003633646061643958, 0.018359512090682983, -0.011264847591519356, 0.010138469748198986, -0.01696968637406826, -0.013057336211204529, -0.02725585363805294, -0.010897567495703697, -0.011765314266085625, 0.01323016919195652, 0.0005717360181733966, 0.028605982661247253, 0.016078129410743713, -0.0013622294645756483, 0.006586835719645023, -0.01595374569296837, -0.010413412004709244, -0.012441522441804409, 0.011101186275482178, 0.008840476162731647, 0.04356500506401062, -0.012184489518404007, -0.007402346469461918, 0.008644591085612774, -0.0008464942802675068, 0.0039163921028375626, -0.08201111853122711, -0.009867970831692219, 0.009197860956192017, -0.03413168340921402, 0.004851477220654488, 0.025295769795775414, -0.0069778296165168285, 0.0126518988981843, -0.009853317402303219, -0.010266589000821114, 0.006375274620950222, -0.006879191379994154, -0.004688560031354427, -0.013527357019484043, 0.01519518531858921, -0.011982878670096397, 0.014747723005712032, -0.023061608895659447, -0.018583951517939568, -0.05663714557886124, -0.017407281324267387, 0.01675659976899624, 0.02377990260720253, -0.0045060524716973305, 0.01372196152806282, 0.003700342494994402, 0.006321334280073643, -0.012185397557914257, 0.01158673781901598, 0.01794074848294258, 0.005321940407156944, -0.01866675168275833, 0.024815330281853676, -0.008715232834219933, 0.007069308310747147, 0.011872108094394207, 0.0070791542530059814, -0.01626618579030037, -0.028072243556380272, 0.035675302147865295, -0.014321915805339813, 0.005428663454949856, 0.005250518210232258, 0.0028646308928728104, 0.022957468405365944, -0.0140576446428895, -0.011840591207146645, -0.008860278874635696, 0.016179723665118217, 0.020020395517349243, -0.016720999032258987, 0.004200473893433809, 0.0038504968397319317, 0.013494033366441727, -0.015873409807682037, 0.0028170067816972733, -0.0010388370137661695, 0.017580173909664154, -0.012002731673419476, -0.004225421696901321, 0.01908339187502861, -0.00032247090712189674, -0.027872195467352867, 0.013728270307183266, -0.0089385025203228, 0.0016885008662939072, 0.02753540500998497, 0.01684197597205639, 0.00033462292049080133, 0.016147620975971222, -0.009800247848033905, 0.00747770257294178, 0.01574152521789074, -0.011716805398464203, 0.009735286235809326, -0.0028030392713844776, -0.016079336404800415, -0.01759704388678074, -0.01495356485247612, -0.03236989676952362, 0.010635404847562313, 0.005048581399023533, 0.0005351578583940864, 0.010239489376544952, -0.020884204655885696, -0.022708924487233162, 0.004217950627207756, 0.04082711786031723, 0.005679527297616005, -0.013585930690169334, -0.001841188408434391, 0.007842134684324265, -0.014016445726156235, 0.009821588173508644, -0.0036936867982149124, -0.008003916591405869, -0.04319411516189575, -0.008793748915195465, -0.008981968276202679, 0.00932479090988636, -0.027433983981609344, -0.004593584220856428, -0.004984604194760323, -0.002258522901684046, 0.00702262157574296, 0.013082397170364857, -0.012125994078814983, 0.0011255485005676746, -0.002735612913966179, 0.00025440414901822805, -0.007607266306877136, 0.009582264348864555, -0.006237744353711605, 0.009594702161848545, 0.013248992152512074, 0.03106335550546646, -0.014487214386463165, 0.010371079668402672, 0.07164987176656723, 0.0178578719496727, -0.009280674159526825, -0.009757941588759422, 0.000805817311629653, -0.03644351288676262, -0.001095231855288148, 0.022362809628248215, 0.0035949377343058586, 0.009674891829490662, 0.015324417501688004, -0.007873201742768288, -0.018212027847766876, 0.00838694628328085, -0.03388197720050812, -0.004488558508455753, 0.004972099792212248, -0.020736025646328926, -0.0019767675548791885, 0.012884637340903282, -0.010110490024089813, -0.016497153788805008, -0.004114931914955378, -0.017984936013817787, 0.016149267554283142, -0.03819051757454872, 0.011758234351873398, -0.009763427078723907, -0.014061305671930313, 0.008497118949890137, 0.011023970320820808, -0.01968919113278389, -0.008342579007148743, -0.0025645687710493803, 0.006252474617213011, 0.0019853890407830477, 0.030239548534154892, 0.02471229061484337, -0.004893835633993149, -0.004922104999423027, -0.019822804257273674, -0.011475859209895134, 0.0031777704134583473, 0.012255776673555374, -0.04916279390454292, 0.006600258871912956, 0.008812405169010162, -0.007864223793148994, 0.019788440316915512, -0.02383350394666195, -0.011299152858555317, 0.0008896451909095049, 0.008824467658996582, 0.006264796946197748, 0.0055684116668999195, -0.015304327011108398, 0.04678911343216896, -0.00527635682374239, -0.0009049756918102503, -0.030354438349604607, 0.0011936340015381575, 0.018061907961964607, 0.02026176266372204, -0.03856903314590454, 0.003557938616722822, -0.01840265654027462, 0.011540536768734455, -0.003560019424185157, 0.024070527404546738, -0.01597779244184494, -0.004002739209681749, -0.007192072458565235, 0.010144933126866817, 0.012257780879735947, 0.017861973494291306, 0.0015588374808430672, 0.028680946677923203, -0.010178867727518082, 0.034751445055007935, -0.004188336431980133, -0.019576484337449074, 0.03324344754219055, 0.02046290598809719, -0.0059533314779400826, 0.0018053995445370674, 0.009085307829082012, -0.015585293993353844, -0.07495176792144775, -0.0004011833807453513, -0.008185135200619698, -0.0024079729337245226, 0.01896081119775772, 0.014648234471678734, -0.0083216717466712, 0.012830998748540878, 0.007428534794598818, 0.003436031751334667, -0.017646243795752525, -0.025958983227610588, 0.0037610253784805536, 0.0053773983381688595, 0.011986423283815384, -0.00011238199658691883, -0.014651431702077389, 0.0061273640021681786, 0.01112647820264101, -0.01500842347741127, 0.020632628351449966, -0.006492304615676403, 0.00822735670953989, 0.017300596460700035, -0.0033155777491629124, -0.08061884343624115, 0.0214313305914402, -0.010300740599632263, -0.01405661553144455, 0.0014741115737706423, -0.0018847170285880566, 0.016722233965992928, -0.005470425821840763, -0.0270839873701334, -0.015627752989530563, -0.005470958538353443, -0.007038724608719349, -0.039018839597702026, 0.008636610582470894, -0.007672058418393135, -0.007881036028265953, 0.0069943200796842575, 0.011331039480865002, -0.022347550839185715, -0.016200019046664238, 0.021779300644993782, 0.02712244540452957, -0.013276313431560993, 0.003256264142692089, 0.0004533529281616211, -0.0034847373608499765, -0.0017113795038312674, 0.006712167523801327, 0.007186003960669041, -0.012949911877512932, -0.023684632033109665, -0.02428690902888775, -0.03400498628616333, 0.014456071890890598, 0.008975554257631302, -0.02420327626168728, 0.013270413503050804, 0.0024519267026335, 0.0017134868539869785, 0.00934187788516283, -0.017309371381998062, 0.019152503460645676, -0.005600126925855875, 0.007533046416938305, 0.02157498523592949, -0.009006461128592491, 0.005282361526042223, -0.009008257649838924, 0.02608080580830574, 0.011736053973436356, 0.007637473754584789, -0.020420752465724945, 0.007864981889724731, -0.010288780555129051, 0.022529419511556625, -0.0011376384645700455, -0.0006382822757586837, -0.004353027790784836, 0.012301729992032051, 0.007675794418901205, -0.0019315641839057207, 0.001740355510264635, -0.01900731585919857, 0.07095102220773697, -0.006883854512125254, -0.00039057061076164246, 0.0014271065592765808, 0.002021706197410822, 0.006327785551548004, -0.0006532897241413593, 0.005450247321277857, -0.012169360183179379, -0.023413803428411484, 0.005946889519691467, -0.012075619772076607, 0.010301201604306698, 0.012514269910752773, 0.018778078258037567, -0.009448420256376266, 0.004541956819593906, 0.004050091374665499, -0.0189655888825655, 0.020009716972708702, -0.029247645288705826, -0.004333092365413904, -0.031907204538583755, -0.004995760042220354, 0.011511900462210178, -0.0018271906301379204, -0.01259102113544941, 0.01639576256275177, -0.00041282293386757374, 0.03838987275958061, -0.019767779856920242, -0.007863382808864117, -0.003909420222043991, -0.010227944701910019, 0.0076505523175001144, 0.023740025237202644, 0.021373379975557327, 0.003966237418353558, -0.015720022842288017, 0.034705229103565216, -0.006274538114666939, 0.02033602073788643, 0.0009672676678746939, 0.0010937368497252464, 0.01161994133144617, -0.021686933934688568, 0.00956746842712164, 0.012929581105709076, 0.0015786484582349658, 0.003807451343163848, 0.006341790780425072, -0.009264207445085049, 0.02227809466421604, 0.04562339186668396, -0.018470924347639084, 0.02859419956803322, -0.0085363257676363, 0.011838017962872982, -0.031498104333877563, 0.01004999689757824, 0.012163747102022171, -0.008663086220622063, -0.004407907836139202, -0.024968907237052917, 0.009251995012164116, -0.018521716818213463, 0.005572271533310413, -0.016400760039687157, -0.03987733647227287, 0.015454585663974285, -0.02195417881011963, -0.002914584707468748, 0.006530500948429108, 0.0010082334047183394, 0.0476369746029377, 0.0013946992112323642, 0.03777158632874489, -0.01329081505537033, 0.020454166457057, 0.007976969704031944, -0.008447510190308094, 0.005891336128115654, -0.018740186467766762, 0.007143313065171242, -0.011109355837106705, 0.010118098929524422, 0.013634574599564075, -0.020385462790727615, -0.0033122249878942966, 0.0050381203182041645, -0.003002157434821129, -0.006589126773178577, 0.010274752974510193, 0.032198138535022736, 0.005345440004020929, 0.03655342757701874, 0.01345877256244421, 0.000913053925614804, 0.01693839021027088, 0.009679415263235569, -0.01371601689606905, -0.024314509704709053, -0.019320586696267128, -0.018902655690908432, -0.028868619352579117, -0.0038790504913777113, 0.0036314253229647875, -0.011403588578104973, 0.020078977569937706, -0.01757630705833435, 0.012481970712542534, -0.0017164744203910232, 0.021367158740758896, 0.003446926362812519, -0.011093275621533394, 0.027416681870818138, -0.006570406723767519, 0.011644281446933746, -0.020295633003115654, -0.012227177619934082, -0.0052984971553087234, 0.0023040645755827427, 0.016477204859256744, -0.006485627964138985, 0.010127651505172253, -0.010084034875035286, -0.011829201132059097, 0.0007325020851567388, -0.03829624503850937, -0.0011130927596241236, 0.01199008896946907, -0.005215458571910858, 0.0022361243609339, 0.006850346922874451, -0.012616976164281368, -0.02268349565565586, 0.008458045311272144, -0.0008459277451038361, -0.023568017408251762, 0.0017231570091098547, 0.005706972908228636, -0.016834301874041557, 0.0003746953734662384, 0.02145070768892765, 0.007416789419949055, -0.0008463007397949696, -0.013434617780148983, 0.01598525047302246, 0.016800647601485252, 0.004791893530637026, 0.005054989363998175, -0.0022792816162109375, -0.006783661432564259, -0.0011922649573534727, -0.019063744693994522, 0.01573099195957184, 0.007771158590912819, 0.0065283263102173805, 0.009273936040699482, -0.02092014253139496, -0.005613596178591251, 0.014575162902474403, -0.018294211477041245, 0.022896483540534973, 0.0010711939539760351, -0.014664341695606709, -0.0003038632567040622, 0.012495334260165691, 0.011866118758916855, 0.028269050642848015, 0.026324450969696045, 0.0008221121970564127, 0.0074412887915968895, 0.025429170578718185, -0.03544570505619049, -0.012039662338793278, -0.010290488600730896, 0.008784466423094273, 0.010023853741586208, 0.0132122952491045, -0.010933062061667442, -0.03298225998878479, 0.025418266654014587, -0.008662169799208641, -0.010988869704306126, -0.011329659260809422, 0.002025327878072858, 0.01486591063439846, -0.005711914040148258, -0.030648592859506607, 0.015746260061860085, -0.0023863178212195635, -0.00017106859013438225, 0.02197715826332569, -0.02301672101020813, -0.0149734728038311, -0.009731046855449677, -0.007151941768825054, -0.0023577031679451466, 0.01683901995420456, -0.022538356482982635, 0.00863147247582674 ]
[ 0.6447055339813232, 0.10990693420171738, 0.07322181761264801, 0.17287041246891022, 0.15461532771587372, -0.06373055279254913, 0.15715640783309937, 0.19773684442043304, -0.06255364418029785, -0.6596801280975342, 0.1841408908367157, -0.018709592521190643, -0.5048681497573853, 0.4167214632034302, -0.01814625971019268, 0.5497087836265564, 0.28448113799095154, 0.6241416931152344, -0.2240387201309204, -0.2708399295806885, -0.3620387017726898, -0.08988741040229797, 0.22909343242645264, 0.0039224266074597836, 0.3344689607620239, -0.10700677335262299, 0.3532082736492157, 0.3265661299228668, 0.21345672011375427, -0.3045612573623657, -0.02851724624633789, 0.43851861357688904, 0.09552570432424545, -0.06689855456352234, -0.34205034375190735, -0.0019372134702280164, -0.3184836804866791, -0.06546006351709366, -0.15637527406215668, 0.07870359718799591, -0.4596058428287506, 0.38315168023109436, -0.11012662202119827, 0.4250546097755432, -0.12050240486860275, -0.3577217757701874, -1.5866624116897583, 1.0408614873886108, -0.14025728404521942, 0.5025684237480164, 0.013236339204013348, 0.0010550242150202394, 0.2314751297235489, -0.010681947693228722, 0.11512184888124466, 0.4467446804046631, -0.4916131794452667, 0.08175612986087799, 0.4004175066947937, -0.7858859300613403, 0.21467985212802887, 0.08518845587968826, -0.22514064610004425, -0.03388449549674988, -0.0009888444328680634, 0.6720992922782898, -0.1991238296031952, -0.446410596370697, -0.585757315158844, -0.5750860571861267, 0.375806599855423, -0.3754092752933502, -0.08171482384204865, 0.36500227451324463, -0.029760535806417465, -0.4052238464355469, -0.24803763628005981, -0.38299456238746643, 0.1217750683426857, 0.12511388957500458, -0.45211663842201233, 0.1311422735452652, 0.004718286916613579, 0.057944368571043015, 0.55271315574646, 0.3348349332809448, -0.09957116842269897, 0.8769245147705078, -0.33790653944015503, -0.2571980059146881, 0.03682948648929596, 0.1351657509803772, 0.5417332053184509, 0.12550289928913116, 0.6616611480712891, 0.18827468156814575, 0.20350374281406403, -0.18210811913013458, -0.13322396576404572, 0.1683984100818634, -0.5682551860809326, -0.06127191707491875, -0.16686786711215973, -0.1142878532409668, -0.3559918999671936, 0.023581774905323982, -0.1335849016904831, -0.47555825114250183, -0.394482284784317, 0.1683950126171112, -0.27991002798080444, 0.03751566633582115, -0.3746110200881958, 0.02003820613026619, -0.25146785378456116, 0.12775827944278717, 0.2392265498638153, -0.2954238951206207, -0.21147675812244415, 0.46397915482521057, -0.577542245388031, 1.0054162740707397, -0.19316020607948303, 0.2593868672847748, -0.035057369619607925, -0.17263448238372803, -0.041518907994031906, -0.12259726226329803, -0.11970515549182892, 0.5667814612388611, 0.3018432855606079, 0.9082472324371338, -0.4500645399093628, -0.060317810624837875, -0.10388573259115219, -0.14775560796260834, 0.144034281373024, 0.28604480624198914, -0.06612128764390945, -0.09664829820394516, -0.5531733632087708, -0.7552434206008911, -0.16392847895622253, -0.17043358087539673, -0.03666488453745842, -0.6422300934791565, -0.42489323019981384, -0.11986956745386124, 0.08163927495479584, -0.37774237990379333, -0.04792314022779465, -0.2621351480484009, -0.387004017829895, 0.08726664632558823, 0.3045584559440613, 0.5087680816650391, 0.09881308674812317, -0.13331608474254608, 0.15533705055713654, 0.1761438101530075, -0.07587370276451111, 0.04457464441657066, -0.46124911308288574, -0.38818931579589844, 0.5163466930389404, 0.1306902915239334, 0.3670932352542877, 0.42596757411956787, 0.0013191236648708582, -0.03272699564695358, -0.4753654897212982, -0.21194638311862946, 0.14370976388454437, -0.5265364646911621, 0.06141815707087517, -0.018185092136263847, 0.08733882755041122, -0.2905787527561188, 0.015630513429641724, 0.2967844009399414, -0.6337321996688843, 0.017259223386645317, -0.4009627401828766, -0.5704556703567505, 0.3228297829627991, -0.0964207872748375, 0.251203715801239, -0.007706114556640387, -0.10857143998146057, 0.002616005716845393, -0.18841791152954102, -0.4519081115722656, 0.8026424646377563, -0.4943210780620575, 1.434787392616272, -0.37526553869247437, -0.031075170263648033, 1.3236699104309082, 0.17264440655708313, -0.219922736287117, -0.2495485097169876, 0.020767420530319214, 0.5832513570785522, -0.6158239245414734, -0.652834415435791, 0.0394047349691391, 0.20848658680915833, -0.2793329656124115, 0.06709100306034088, -0.08064984530210495, 0.6403914093971252, -0.22913938760757446, 0.019191520288586617, -0.41862091422080994, 0.17303110659122467, -0.2675667405128479, -0.47661447525024414, 0.043798789381980896, -0.4776195287704468, -0.1122082769870758, 0.320827841758728, -0.5280539989471436, 0.5011662244796753, 0.8143773674964905, -0.2043958455324173, 0.6581404209136963, 0.362224280834198, 0.048837289214134216, 0.7162731289863586, -0.17299458384513855, 0.43221065402030945, -0.6713419556617737, 0.18218161165714264, -0.5687577724456787, -0.6295140981674194, 0.3348916172981262, 0.07723459601402283, 0.0690608024597168, -0.05681658536195755, -0.1197090670466423, 0.03046119585633278, 0.5095553398132324, -0.963871955871582, -0.01849682629108429, -0.10818015784025192, -0.5598431825637817, -0.2654353380203247, 0.26148319244384766, -0.6660351753234863, -0.06947792321443558, 0.21126464009284973, 0.2255868762731552, 0.4141732156276703, -0.45708808302879333, 0.2364961951971054, -0.30734357237815857, -0.15870337188243866, -0.10556725412607193, 0.46603864431381226, -0.46293938159942627, -0.035903677344322205, 0.10483749210834503, -0.19046641886234283, 0.16007483005523682, -0.07760149240493774, -0.11274420469999313, -0.5925018787384033, -0.4019918739795685, 0.6978759169578552, 0.7326892018318176, 0.984805166721344, 0.14687341451644897, -0.5434334874153137, 0.02948394976556301, 0.31423869729042053, -0.5417370200157166, 0.6243844628334045, 0.7020069360733032, -0.37309107184410095, -0.35188812017440796, -0.34762945771217346, 0.41596004366874695, 0.7915298342704773, -0.05947307497262955, -0.33014097809791565, -0.25010982155799866, -0.4410448968410492, -0.05317113175988197, -0.4814910292625427, -0.07206657528877258, -0.28952252864837646, 0.2727612555027008, -0.5167257785797119, -0.06480253487825394, 0.14318948984146118, 0.15900591015815735, -0.17390617728233337, 0.042989443987607956, 0.7508272528648376, -0.23642697930335999, -0.10119254887104034, 0.1517157107591629, -0.14972664415836334, -0.03664996102452278, -0.17328904569149017, 0.14840906858444214, -0.32055360078811646, 0.32708504796028137, -6.094038486480713, -0.09198979288339615, 0.05764996260404587, -0.04576476290822029, -0.13124828040599823, -0.11818766593933105, 0.9274253845214844, 0.05416075885295868, 0.38981306552886963, 0.2190542370080948, 0.2718175947666168, 0.5102412700653076, -0.0729123130440712, -0.24506191909313202, -0.21942177414894104, 0.24925492703914642, -0.18979427218437195, -0.33068203926086426, 0.239826038479805, -0.04341595247387886, 0.04964515194296837, 0.2576959729194641, -0.24123072624206543, 0.9460276961326599, -0.29714876413345337, -0.008299946784973145, -1.17654287815094, 0.41810110211372375, 0.12603482604026794, -0.11358626186847687, -0.07504958659410477, -0.5526489019393921, 0.04628788307309151, -0.20912252366542816, 0.41682517528533936, -0.007329333107918501, -0.18056906759738922, -0.1994200348854065, -0.2468554526567459, -0.0757082924246788, 0.23238709568977356, 0.33249470591545105, -0.4506189525127411, -0.3590608835220337, 0.41698771715164185, -0.10422535240650177, -0.3044390082359314, 0.15282583236694336, -0.32109594345092773, 0.4322534501552582, -0.13309074938297272, -0.08237429708242416, 0.4137524664402008, 0.6657696962356567, 0.3965819776058197, 0.2926478981971741, 0.009010779671370983, -0.2377701699733734, -0.6404502391815186, -0.14822138845920563, -0.3577619791030884, 0.003051038598641753, -0.08612431585788727, -0.07899543642997742, 0.3559250831604004, 0.17320452630519867, -0.6809409260749817, -0.420179158449173, 0.12086112052202225, -0.2768095135688782, -0.2074640393257141, 0.333312451839447, 0.15747560560703278, -0.6128201484680176, 0.42534971237182617, -0.2652128040790558, 0.006843054201453924, 0.17252309620380402, 0.2708227336406708, 0.10305251181125641, -0.33801019191741943, 0.19592073559761047, -0.2402806580066681, -0.08833052217960358, -0.05836990103125572, -0.5100125670433044, -0.20707090198993683, -0.29923683404922485, -0.5240046977996826, 0.3709159791469574, 0.35513395071029663, -0.11361732333898544, 0.2527305781841278, 0.8250229358673096, 0.08720313757658005, 0.3490273952484131, 0.09117627888917923, 0.45141640305519104, 0.18360261619091034, 0.014882378280162811, 0.8127180337905884, -0.05065860599279404, -0.43504583835601807, -0.8191832900047302, 0.1676402986049652, 0.08351701498031616, -0.5287050008773804, 0.3798067569732666, 0.5131368637084961, -0.8276180028915405, 0.11022719740867615, 0.43837782740592957, -0.07782675325870514, 0.026160288602113724, 0.8220111727714539, -0.20621736347675323, 0.08245734125375748, 0.24784214794635773, 0.8059684634208679, -0.29919949173927307, 0.3042810559272766, 0.6106118559837341, -0.15643809735774994, 0.1589902937412262, 0.08665847778320312, -0.17172835767269135, 0.1541348695755005, 0.42679715156555176, -0.740990161895752, -0.08525214344263077, 0.5523643493652344, 0.6146764159202576, -0.0555378794670105, 0.010775447823107243, 0.3123244643211365, -0.110530786216259, -0.3769124746322632, 0.08442137390375137, -0.0051578255370259285, -0.3921700716018677, 0.13421756029129028, -0.16656450927257538, 0.0025658253580331802, -0.040110766887664795, 0.13877592980861664, 0.1057942658662796, -0.04846891015768051, 0.23331274092197418, -0.2516806125640869, -0.2691364586353302, 0.24470087885856628, 0.08976125717163086, -0.2637915015220642, 0.0331689715385437, -0.31602439284324646, 0.4227164089679718, 0.7441192269325256, 0.26921775937080383, 0.4410460293292999, -0.5130248069763184, 0.039056435227394104, 0.4073052406311035, -1.103554606437683, 0.28199660778045654, -0.6695569753646851, -0.3768433928489685, -0.22590653598308563, -0.4260401427745819, 0.09238748997449875, 0.16428303718566895, -0.24662761390209198, -0.2155979573726654, -0.3898985981941223, -0.1142551526427269, 0.08874544501304626, -0.2775712311267853, -0.22027556598186493, 0.016379091888666153, -0.3582973778247833, 0.29524561762809753, 0.3337838053703308, -0.735198974609375, -0.37479367852211, 0.2858732044696808, 0.47324368357658386, 0.09826412796974182, 0.19593863189220428, -0.2509608566761017, -0.23817014694213867, -0.20382919907569885, 0.21436963975429535, 0.10688631981611252, 0.07731730490922928, -0.1449417769908905, 0.05937526747584343, 0.22521188855171204, 0.11600544303655624, 0.11721422523260117, 0.05436426028609276, -0.4830016493797302, 0.2140025943517685, 0.5253315567970276, -0.5275525450706482, 0.11166685819625854, 0.22419123351573944, 0.05507880076766014, -0.4418186545372009, -0.1263146996498108, -0.06480389088392258, -0.07392053306102753, -0.3749586045742035, -0.2081642597913742, 0.3549269735813141, 0.31116703152656555, -0.08607357740402222, -0.003588976338505745, 0.21933743357658386, -0.21953806281089783, -0.16723282635211945, 0.3456552028656006, 0.10887505114078522, -0.10323680937290192, -0.06691792607307434, -0.2750999331474304, -0.2688698172569275, 0.21768996119499207, 0.31001123785972595, -0.6091389656066895, 0.08361658453941345, 0.5048888921737671, 0.2544217109680176, -0.29014718532562256, 0.1276695430278778, 0.20156215131282806, 0.13114012777805328, -0.08510351926088333, -0.21415679156780243, 0.27444323897361755, 0.20290488004684448, 0.20337267220020294, 0.5653848648071289, 0.21852543950080872, -0.40449056029319763, -0.03222467377781868, 0.21660636365413666, 0.7230975031852722, 0.3422721326351166, -0.3959512412548065, -0.4281283915042877, 0.061217546463012695, 0.39299389719963074, -0.5799650549888611, 0.2134440392255783, 0.3660348951816559, 0.8146926760673523, 0.16523535549640656, 0.11092665046453476, -0.22771817445755005, -0.0062623699195683, 0.013331003487110138, -0.11591556668281555, 0.09619017690420151, -0.17265662550926208, 0.22051434218883514, 0.0840533897280693, 0.007153088692575693, -0.22831174731254578, -0.6183695793151855, 0.3180600106716156, 0.013638360425829887, 0.31767597794532776, 0.17862263321876526, 0.5964246392250061, 0.663239061832428, -0.3436782658100128, 0.4609396159648895, -0.6164349317550659, -0.0018715898040682077, -0.2374221235513687, 0.03360426425933838, -0.34183433651924133, -0.5563226938247681, 0.04711949825286865, -0.42353323101997375, 0.592843770980835, -0.47963783144950867, 0.297574907541275, -0.296703964471817, 0.10274817049503326, -0.3969201147556305, -0.4395425319671631, -0.1936059445142746, -0.5921145677566528, -0.5946371555328369, 0.25417712330818176, 0.12554046511650085, -0.13512279093265533, 0.13874571025371552, 0.01695910096168518, -0.002286795526742935, -0.7530941963195801, 0.34502843022346497, 0.400633841753006, -0.31570231914520264, 0.01640399731695652, 0.40117087960243225, 0.18056900799274445, 0.24595801532268524, -0.4561620354652405, -0.2469649314880371, -0.0611533597111702, -0.055125802755355835, 0.059183038771152496, 0.13072282075881958, -0.1359584480524063, 0.25742655992507935, -0.34499257802963257, -0.05607284978032112, 0.3228055238723755, 0.14414677023887634, 0.22732935845851898, 0.2830485701560974, 0.08768711984157562, -0.29333919286727905, 0.1999214142560959, 0.3806876838207245, 0.40639376640319824, 0.22943535447120667, -0.4406430721282959, 0.6505550742149353, 0.4496360719203949, 0.3126932680606842, -0.3020005226135254, 0.4245622158050537, 0.4152105748653412, 0.3168548047542572, 0.19236576557159424, -0.4952738881111145, -0.19582082331180573, 0.07469409704208374, 0.5826402306556702, -0.03935317322611809, -0.0928378477692604, -0.40176230669021606, 0.11311303824186325, 0.4463097155094147, -0.2889082729816437, 0.16544435918331146, -0.10993941873311996, 0.10582751035690308, 0.2369106560945511, -0.40825918316841125, -0.421160489320755, 0.22995032370090485, -0.42460793256759644, -0.02760344184935093, 0.598537266254425, -0.6563310027122498, -0.6748872995376587, 0.18876959383487701, -0.36957526206970215, 0.23629677295684814, 0.1017586812376976, 0.5063264966011047, 0.18021218478679657, 0.31304609775543213, 0.44012048840522766, -0.16156882047653198, 0.10407407581806183, -0.1976201832294464, 0.0542169064283371, -0.042408477514982224, -0.2538403868675232, 0.27405357360839844, 0.2778971493244171, -0.19009898602962494, 0.1495559811592102, 0.12136217206716537, 0.3092474341392517, 0.43020856380462646, -0.08297958225011826, 0.31856074929237366, 0.019275814294815063, -0.8094733953475952, -0.20498669147491455, -0.07469666749238968, -0.6931988000869751, 0.1270231306552887, 0.1996091604232788, 0.07420976459980011, 0.06540748476982117, -0.9132943153381348, 0.03441419452428818, 0.30376842617988586, 0.06210717931389809, 0.0396435484290123, 0.10569925606250763, 0.2359337955713272, 0.19420254230499268, -0.0861101746559143, 0.04335326701402664, 0.19443029165267944, 0.07189708203077316, 0.29119208455085754, -0.9390553832054138, 0.5393498539924622, -0.48932382464408875, -0.3158308267593384, -0.3864023685455322, -0.039717789739370346, 1.0874433517456055, 0.05102524161338806, -0.4460048973560333, 0.11193715035915375, 0.3696594834327698, 0.2959301173686981, 0.35063302516937256, -0.5645741820335388, -0.44561105966567993, -0.6100835204124451, -0.14628803730010986, -0.3645990788936615, 0.556259274482727, 0.15549656748771667, -0.06557536125183105, 0.16673322021961212, 0.14611934125423431, 0.3768909275531769, -0.12099849432706833, 0.35206368565559387, -0.6333054304122925, 0.2782825529575348, -0.6414675116539001, 0.2514028251171112, -0.07213066518306732, -0.13229979574680328, -0.21536105871200562, 0.3941238522529602, 0.12000882625579834, -0.30597013235092163, 0.21633583307266235, -0.5519979596138, 0.08743393421173096, -0.26882219314575195, 0.324966698884964, 0.44105103611946106, 0.08072958141565323, -0.49188873171806335, -0.455469012260437, -0.04925476387143135, 0.13722294569015503, -0.6547607779502869, -0.1959124505519867, 0.3234148323535919, 0.041096337139606476, 0.006347025744616985, -0.1539711356163025, -0.3167409896850586, -0.15067127346992493, -0.00010261715215165168 ]
Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas ( TCGA) pilot project aims to assess the value of large- scale multi- dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community. Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas - the most common type of primary adult brain cancer - and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 and TP53, uncovers frequent mutations of the phosphatidylinositol- 3- OH kinase regulatory subunit gene PIK3R1, and provides a network view of the pathways altered in the development of glioblastoma. Furthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications. Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.
[ -0.013386785984039307, -0.0012248042039573193, -0.001322515425272286, 0.009548733942210674, 0.01526664663106203, -0.026077697053551674, 0.00912969559431076, -0.006732345558702946, -0.0113837206736207, 0.009142792783677578, -0.0006820958224125206, 0.00823089201003313, -0.0005484791472554207, 0.017165526747703552, -0.03942427039146423, 0.016613909974694252, -0.02351963147521019, 0.011371065862476826, 0.014458857476711273, 0.016234364360570908, 0.016508283093571663, -0.01886284351348877, 0.010015398263931274, 0.03416375443339348, 0.013886545784771442, 0.009733056649565697, -0.019340017810463905, 0.014082683250308037, -0.01078129280358553, 0.00370007217861712, -0.0157236997038126, 0.012269478291273117, 0.037096694111824036, -0.0009464859031140804, -0.001699947752058506, -0.02183113619685173, -0.0023258610162883997, 0.021454427391290665, 0.025503966957330704, -0.00465620681643486, 0.020075511187314987, -0.0064207036048173904, 0.0017369658453390002, -0.01221681758761406, -0.010218221694231033, 0.005891974084079266, -0.004125121980905533, 0.02204371616244316, 0.021918930113315582, 0.012539774179458618, -0.013696398586034775, -0.01003294624388218, -0.008191151544451714, 0.003704114817082882, -0.006367891561239958, -0.0028549872804433107, 0.019157981500029564, 0.01348594669252634, 0.00786725152283907, 0.007814855314791203, 0.0050645507872104645, -0.021605700254440308, 0.017059210687875748, -0.004759074188768864, -0.023976357653737068, -0.06664101034402847, 0.0400012843310833, 0.027859019115567207, -0.004662327002733946, 0.005343385506421328, 0.006858145818114281, 0.009630334563553333, 0.023164942860603333, -0.00029831426218152046, -0.02407013066112995, 0.011286895722150803, -0.012360741384327412, -0.008156231604516506, 0.009389327839016914, 0.03198728337883949, -0.01994822733104229, -0.031332314014434814, 0.016575075685977936, 0.03161950409412384, -0.0023602815344929695, 0.009197539649903774, -0.013644165359437466, -0.003435252234339714, 0.031018394976854324, 0.018432065844535828, 0.011609714478254318, -0.013599531725049019, -0.0350910946726799, -0.011877750046551228, -0.0424511581659317, -0.001538868178613484, -0.0025631843600422144, -0.022909050807356834, 0.022762451320886612, -0.00819547101855278, -0.019139939919114113, 0.013294924050569534, 0.020042724907398224, -0.013383990153670311, -0.010100195184350014, 0.004475388675928116, -0.02711597830057144, -0.004897821694612503, 0.024812646210193634, 0.0054261451587080956, -0.014535324648022652, 0.006478650029748678, -0.011651502922177315, 0.0353248231112957, 0.0011693602427840233, 0.010446976870298386, 0.005282807629555464, 0.014154510572552681, 0.004744051024317741, -0.007665675599128008, 0.01078152097761631, -0.01083286665380001, -0.011182589456439018, 0.02011473849415779, 0.006156515795737505, -0.018378980457782745, 0.0069328551180660725, 0.002370453206822276, 0.014102826826274395, 0.006243458483368158, -0.00962916761636734, 0.024388428777456284, -0.022091634571552277, -0.007955675944685936, -0.01036553829908371, -0.006059869658201933, -0.03699570149183273, -0.008104782551527023, -0.002382711973041296, 0.007978292182087898, 0.011384567245841026, 0.009087562561035156, 0.006390465889126062, 0.008119945414364338, 0.01668894663453102, 0.011820906773209572, 0.0009121234761551023, 0.0028652860783040524, -0.008116149343550205, -0.015100964345037937, 0.008683002553880215, 0.0044409120455384254, -0.015030701644718647, -0.010877519845962524, 0.003106949385255575, -0.00019436562433838844, 0.0007060077041387558, -0.00979967787861824, -0.014185584150254726, 0.00939319096505642, 0.01763942465186119, -0.022877665236592293, 0.023439457640051842, 0.009526161476969719, 0.009020520374178886, -0.027369048446416855, -0.027389269322156906, -0.004007659386843443, 0.0031931016128510237, 0.009523514658212662, -0.01005731150507927, -0.005252625793218613, -0.017595604062080383, 0.009887922555208206, -0.011880683712661266, 0.00021620886400341988, 0.02687688171863556, 0.006525663658976555, -0.009265727363526821, 0.06642653793096542, -0.02829866111278534, 0.012876161374151707, -0.005863630212843418, -0.015890954062342644, 0.025702539831399918, -0.015261262655258179, -0.0059056999161839485, -0.006201934535056353, -0.018783966079354286, 0.010821385309100151, 0.014584461227059364, 0.012612036429345608, -0.010243495926260948, 0.0035116714425385, -0.011234463192522526, 0.002121820580214262, 0.0029022814705967903, 0.003548776265233755, 0.01791110634803772, 0.0027728620916604996, 0.004252467770129442, 0.009075870737433434, 0.02364419400691986, -0.005164989270269871, 0.004527598153799772, 0.0027391936164349318, 0.03141622245311737, -0.018307819962501526, -0.004571951925754547, -0.017147084698081017, 0.029366280883550644, -0.0018500291043892503, -0.018391694873571396, -0.003453782293945551, 0.012028015218675137, 0.01936129294335842, 0.0021927678026258945, -0.0001072930172085762, -0.020851798355579376, -0.010660883970558643, 0.00011192033707629889, -0.002179733943194151, -0.007643606513738632, 0.012436538003385067, 0.013174494728446007, -0.018051518127322197, 0.008460328914225101, 0.009067189879715443, 0.01718101277947426, -0.015151431784033775, -0.012571846134960651, -0.017932072281837463, -0.009533919394016266, 0.005736479535698891, 0.013179494068026543, 0.02057061344385147, 0.014669457450509071, -0.029193390160799026, 0.014927515760064125, -0.013151619583368301, -0.014260446652770042, -0.012186147272586823, 0.005296265706419945, -0.009098075330257416, 0.007349938154220581, 0.0010775281116366386, 0.02551763504743576, 0.014862620271742344, -0.0022650202736258507, -0.018449340015649796, 0.0068106395192444324, -0.022137105464935303, 0.012452355585992336, 0.007404074538499117, 0.02332189679145813, 0.010463920421898365, -0.007477359846234322, -0.004270811565220356, 0.023531310260295868, 0.011542604304850101, 0.0039029414765536785, 0.011502085253596306, 0.02176426723599434, 0.0048734513111412525, -0.01841158978641033, 0.006292528472840786, 0.04377128928899765, 0.013648522086441517, -0.0030138185247778893, -0.009257595054805279, 0.00894287507981062, -0.010054314509034157, 0.010389555245637894, -0.08123581856489182, -0.007715909276157618, 0.0026361732743680477, -0.0003890162333846092, 0.011876116506755352, 0.01929997280240059, 0.00740879587829113, 0.008809725753962994, -0.008258800953626633, -0.03201382979750633, 0.00805977825075388, 0.006741094868630171, -0.011036254465579987, 0.005043440032750368, -0.00015696976333856583, -0.009308313019573689, 0.012100127525627613, -0.021491458639502525, 0.004508247599005699, -0.04908515885472298, 0.03228099271655083, 0.011190218850970268, 0.003185573033988476, -0.0052200499922037125, 0.00014408910647034645, 0.01353514101356268, 0.011893088929355145, 0.004987962078303099, -0.011700949631631374, 0.013668810948729515, -0.002395820803940296, 0.0006809822516515851, 0.02506924793124199, -0.005030661355704069, 0.02035953849554062, 0.006129702553153038, -0.0011207247152924538, 0.02065819501876831, -0.007033000234514475, 0.002984986174851656, -0.01333309430629015, 0.013224123045802116, -0.001195498974993825, -0.01799033023416996, 0.004645200911909342, 0.019217411056160927, -0.012426188215613365, 0.0025143513921648264, 0.017619840800762177, -0.0044547379948198795, 0.028511177748441696, 0.005715466104447842, 0.048830170184373856, 0.008115196600556374, -0.010087184607982635, -0.02313530072569847, -0.021992169320583344, 0.013143355026841164, -0.010991927236318588, -0.007621415425091982, 0.020437482744455338, 0.002491894643753767, -0.024128612130880356, 0.009270546026527882, 0.024637704715132713, 0.00119263946544379, 0.012880627065896988, -0.020679857581853867, -0.011380673386156559, -0.009896665811538696, -0.0008077943930402398, 0.013997356407344341, 0.002793737454339862, -0.006608166731894016, -0.0010005934163928032, -0.0043388898484408855, -0.01764870248734951, -0.00816237274557352, -0.001995498314499855, -0.006110637914389372, -0.0007243002764880657, -0.010303175076842308, -0.002446481492370367, -0.0006901433225721121, -0.010708453133702278, -0.02021041326224804, -0.00009819905972108245, 0.026327544823288918, 0.008417664095759392, -0.01838964968919754, -0.009550949558615685, 0.009604818187654018, -0.020964007824659348, 0.010496797040104866, 0.00847663450986147, -0.016047552227973938, -0.015267765149474144, 0.0015869596973061562, 0.019298367202281952, 0.008114207535982132, 0.0033240490593016148, 0.006034735590219498, 0.022999107837677002, -0.012613009661436081, -0.015127102844417095, 0.017600983381271362, 0.013284463435411453, -0.0021349946036934853, 0.0030130271334201097, 0.00032808363903313875, 0.010097518563270569, 0.011849906295537949, -0.007812819443643093, 0.012936892919242382, 0.010198495350778103, 0.01764572598040104, -0.013551735319197178, -0.01220052968710661, 0.07198882848024368, -0.007463456597179174, 0.01295682042837143, -0.017937662079930305, -0.0021166426595300436, -0.01150757260620594, 0.018345609307289124, 0.0034751873463392258, -0.011018384248018265, 0.005032948683947325, 0.011087741702795029, -0.010490838438272476, 0.03871174901723862, 0.016781799495220184, -0.009037846699357033, 0.02118765562772751, 0.006181140895932913, 0.004901112988591194, -0.013300932012498379, -0.01874930039048195, -0.010590866208076477, -0.022945139557123184, -0.007566553074866533, 0.010766619816422462, -0.014888941310346127, 0.010671842843294144, 0.019510140642523766, -0.01173027977347374, -0.008575612679123878, 0.014132248237729073, 0.001982390182092786, 0.01783621497452259, -0.006933818571269512, 0.042350348085165024, 0.015908055007457733, 0.0015183843206614256, -0.009859079495072365, -0.008019261062145233, -0.0012968494556844234, -0.009405023418366909, -0.0017978730611503124, -0.014806733466684818, 0.00957399234175682, 0.015903964638710022, -0.02015233039855957, 0.010166702792048454, 0.022310981526970863, -0.00676007941365242, 0.012621013447642326, 0.02190144546329975, -0.00146606401540339, -0.007313216105103493, 0.008753403089940548, 0.032946694642305374, 0.01858161762356758, -0.003435632213950157, 0.020493440330028534, -0.019538255408406258, 0.006631570402532816, -0.006289885379374027, -0.02199922688305378, -0.008869480341672897, 0.039054155349731445, 0.013476050458848476, 0.02201116271317005, -0.01193656213581562, -0.0022660200484097004, -0.0034513382706791162, 0.0178707093000412, -0.005002469290047884, 0.010248420760035515, 0.0004589548334479332, -0.015078157186508179, -0.014010881073772907, -0.0136768389493227, 0.02889607846736908, -0.007826477289199829, -0.03153717890381813, -0.009644548408687115, -0.0019390895031392574, 0.007079286500811577, -0.018925519660115242, 0.0015005250461399555, 0.003227389184758067, -0.003830838715657592, -0.005989531520754099, -0.0019639041274785995, -0.07460658252239227, -0.0011258054291829467, -0.017039388418197632, -0.0035394623409956694, -0.0018720738589763641, -0.0011394645553082228, -0.005285888444632292, -0.02480926737189293, -0.0025044819340109825, -0.0006249251891858876, 0.0034184602554887533, -0.00756655540317297, -0.005975666921585798, -0.009563049301505089, 0.012747985310852528, 0.043880462646484375, -0.021774237975478172, -0.01467326283454895, -0.03584866225719452, 0.021253198385238647, 0.003126010298728943, 0.020068421959877014, -0.0015130209503695369, -0.007993713952600956, -0.010309119708836079, -0.08102861046791077, 0.009927995502948761, -0.011869143694639206, 0.009848810732364655, -0.010098986327648163, 0.010143846273422241, 0.010384630411863327, -0.010619946755468845, 0.00703843217343092, -0.014423348009586334, -0.005052879918366671, 0.009863335639238358, -0.0007520522922277451, 0.010868985205888748, -0.02439185604453087, -0.01162964478135109, 0.008452111855149269, -0.013524730689823627, -0.005450668279081583, -0.0021197395399212837, -0.023095659911632538, 0.02005000039935112, -0.008904690854251385, -0.018408875912427902, -0.008599439635872841, -0.010942216962575912, -0.00311920209787786, 0.017898311838507652, 0.008811967447400093, -0.004529974423348904, 0.007867460139095783, -0.009457780048251152, -0.013904060237109661, -0.01791868917644024, -0.021590478718280792, -0.031292181462049484, 0.00824032723903656, -0.01563211902976036, -0.0036803269758820534, 0.0006685048574581742, -0.006626044400036335, 0.028890198096632957, -0.01675453782081604, -0.0009720148518681526, -0.01909395307302475, 0.009664295241236687, 0.007868735119700432, -0.006933743599802256, 0.002208918333053589, -0.0023640247527509928, 0.0025603589601814747, -0.008752794936299324, -0.0076704784296453, 0.019822878763079643, 0.022228766232728958, -0.00962208490818739, -0.0007948909187689424, -0.0008773519657552242, 0.02092561684548855, 0.015153041109442711, 0.007620852440595627, 0.02091238647699356, 0.012724524363875389, 0.07141102105379105, 0.016041165217757225, 0.012750822119414806, -0.006483080796897411, -0.013003559783101082, 0.00391880189999938, -0.016064878553152084, 0.017250891774892807, -0.017312683165073395, 0.008924610912799835, 0.008114189840853214, -0.01226640772074461, 0.0015400410629808903, 0.01170648168772459, -0.03748070448637009, -0.00017487164586782455, -0.030049392953515053, 0.007562729995697737, 0.0018751171883195639, -0.017225055024027824, 0.005146265961229801, 0.03264545649290085, -0.007852718234062195, 0.0050071547739207745, -0.004270677454769611, -0.01772407628595829, -0.03989480435848236, 0.0008656212594360113, -0.01625979132950306, -0.013233715668320656, -0.001336154993623495, 0.02514166757464409, -0.002678698394447565, 0.013521462678909302, 0.022178176790475845, 0.012603634968400002, -0.011687510646879673, 0.010052436031401157, 0.0048064664006233215, -0.015408147126436234, -0.0021359561942517757, -0.006559989880770445, 0.0025748834013938904, 0.010725177824497223, 0.00939483568072319, -0.02629946731030941, -0.008799548260867596, 0.009810468181967735, -0.009081050753593445, 0.022103548049926758, 0.012644628062844276, 0.005290252156555653, 0.006247684825211763, -0.005396675318479538, 0.01979062706232071, 0.022179963067173958, -0.004586390219628811, 0.014060474932193756, -0.024826232343912125, 0.002295116428285837, 0.019661519676446915, -0.01984989084303379, -0.02596871368587017, -0.015571817755699158, 0.005376892164349556, -0.011478884145617485, 0.014776232652366161, -0.01950521022081375, 0.023398468270897865, 0.014799170196056366, 0.018106870353221893, -0.02281573787331581, 0.011227110400795937, 0.013269003480672836, -0.00005894317291676998, -0.0028142258524894714, -0.022874299436807632, 0.029981788247823715, 0.020126353949308395, -0.0030187037773430347, -0.0147378696128726, -0.0033595063723623753, 0.0007388475351035595, 0.011442597024142742, -0.014862732030451298, 0.01591208577156067, 0.02113635092973709, -0.018042687326669693, -0.0018642137292772532, 0.003963148221373558, 0.04073986038565636, 0.007821191102266312, 0.0042635896243155, 0.002117234282195568, 0.010914288461208344, 0.033507030457258224, 0.0010559656657278538, 0.000867492170073092, -0.0030060913413763046, 0.0036079618148505688, 0.009515219368040562, -0.0022424091584980488, -0.02818174660205841, -0.010027340613305569, -0.009189157746732235, -0.00536356633529067, -0.011334266513586044, -0.0029538562521338463, -0.006426891312003136, 0.01263599842786789, 0.010639961808919907, -0.022377174347639084, 0.019787153229117393, -0.001150625292211771, 0.010010036639869213, 0.01469034980982542, -0.01316557265818119, 0.03295344486832619, 0.010649025440216064, -0.020608244463801384, -0.016222629696130753, -0.016145026311278343, -0.009860971942543983, 0.036508526653051376, 0.021947458386421204, 0.0048761130310595036, -0.013879800215363503, 0.004825902637094259, -0.004549595061689615, -0.01490798220038414, 0.008065068162977695, -0.03784091770648956, 0.012406720779836178, 0.022212877869606018, 0.006474443711340427, 0.0026797775644809008, -0.0015010291244834661, 0.0026191831566393375, -0.017239632084965706, 0.02417372725903988, 0.009657606482505798, -0.00791137758642435, 0.0010324843460693955, 0.015357921831309795, 0.008408810943365097, -0.014879485592246056, -0.0011513838544487953, 0.01486143097281456, 0.0154524315148592, -0.007586572784930468, 0.009299409575760365, 0.00015680119395256042, -0.013766288757324219, -0.009778227657079697, -0.016938507556915283, 0.01836295612156391, 0.0029463977552950382, 0.016551923006772995, 0.0032109860330820084, 0.014166783541440964, -0.01755589246749878, -0.0074028195813298225, -0.003851945511996746, -0.027181392535567284, 0.0048018693923950195, 0.009721163660287857, -0.017109530046582222, 0.014595700427889824, -0.003937434870749712, -0.0033975373953580856, 0.01307685300707817, 0.011544998735189438, -0.01477908156812191, 0.009456194937229156, -0.03215516731142998, 0.0028760849963873625, -0.022039297968149185, -0.0023449710570275784, -0.0006894718389958143, -0.0157151035964489, 0.009819350205361843, 0.004586806520819664, -0.004384269006550312, -0.011953971348702908, -0.014855151996016502, 0.012404175475239754, -0.012310253456234932, -0.00396127300336957, 0.017242077738046646, 0.00681055523455143, -0.011016124859452248, -0.014027134515345097, -0.01566508784890175, -0.0029700705781579018, -0.007972725667059422, -0.008528783917427063, 0.021451003849506378, 0.029759163036942482, 0.00005912932101637125, -0.007055568043142557, 0.015762556344270706, -0.009089034050703049 ]
[ 0.199859157204628, 0.4500839114189148, -0.23344962298870087, 0.2202313095331192, 0.6247330904006958, 0.18169927597045898, 0.17095094919204712, 0.3190312087535858, -0.0026207645423710346, -0.4603945016860962, 0.124504953622818, -0.028710968792438507, -0.3510075509548187, 0.3897912800312042, 0.05603821203112602, 0.5671415328979492, 0.4580382704734802, 0.1503414809703827, 0.07487070560455322, -0.5488604307174683, -0.2697739601135254, -0.6183428764343262, 0.877801775932312, -0.12227313220500946, 0.025362428277730942, -0.3623110055923462, 0.18689291179180145, -0.026908110827207565, 0.004032217897474766, 0.2013639360666275, -0.4584711790084839, 0.6649993658065796, 0.18404316902160645, -0.23184417188167572, 0.15266601741313934, -0.34273645281791687, -0.448246031999588, -0.07009619474411011, -0.03620648756623268, -0.2509669363498688, 0.17357441782951355, -0.12919846177101135, -0.396883100271225, 0.4136144518852234, -0.29554659128189087, -0.06981213390827179, -0.9121830463409424, 1.0533905029296875, 0.171657532453537, 0.24516336619853973, 0.21536092460155487, 0.017530564218759537, 0.090159572660923, 0.26925602555274963, 0.17808395624160767, 0.2603219449520111, -0.16311879456043243, 0.0968640148639679, 0.2232861965894699, -0.2288493663072586, 0.197958841919899, -0.1149023026227951, -0.4719584882259369, 0.24912631511688232, 0.2803950607776642, 0.5821073055267334, 0.34917911887168884, -0.4133428931236267, -0.834999144077301, -0.41406190395355225, 0.09504431486129761, -0.3291585147380829, 0.1345609575510025, 0.7304571270942688, -0.16963155567646027, -0.021042484790086746, -0.24405299127101898, -0.3006965219974518, 0.3465370237827301, -0.13199175894260406, 0.15899452567100525, -0.019732097163796425, 0.5187059640884399, 0.4758380949497223, 0.048182085156440735, -0.1389877051115036, -0.1077287420630455, 0.38785114884376526, -0.1893353909254074, -0.3265096843242645, -0.17660218477249146, -0.15718235075473785, 0.5560196042060852, 0.5674639940261841, 0.3098908066749573, 0.48380982875823975, 0.04459880664944649, 0.04290550574660301, -0.24738022685050964, 0.02955501526594162, -0.3987258970737457, 0.5416619777679443, 0.05724940821528435, -0.21955831348896027, -0.6152452230453491, -0.32451003789901733, -0.019381683319807053, 0.015405138023197651, -0.2692751884460449, 0.08615224808454514, -0.6613017916679382, -0.12536312639713287, -0.4934788942337036, 0.026858501136302948, -0.5256826877593994, 0.13928845524787903, 0.07502108067274094, -0.8143053650856018, 0.14637744426727295, -0.1115381047129631, -0.4045230448246002, 0.9133715629577637, -0.46998992562294006, 0.12251552939414978, -0.02369288168847561, -0.09159453958272934, 0.5175791382789612, -0.07548366487026215, 0.1674794852733612, 0.23148274421691895, -0.11314979195594788, 1.0004962682724, -0.34412968158721924, -0.04733491316437721, 0.4169715940952301, -0.35821840167045593, -0.06569016724824905, 0.05819554626941681, 0.6972795128822327, 0.030344568192958832, -0.41774898767471313, -1.0567970275878906, -0.18233627080917358, -0.11624093353748322, 0.16059300303459167, -0.3736567199230194, -0.06440423429012299, -0.1911129504442215, -0.17368517816066742, -0.7093960046768188, -0.05921187996864319, -0.012946019880473614, -0.5256457328796387, -0.240519717335701, 0.2987036108970642, 0.26028284430503845, -0.20164000988006592, -0.23119281232357025, 0.14713048934936523, 0.15621916949748993, -0.05560928210616112, 0.02112799696624279, -0.2450585812330246, -0.06679990142583847, 0.3776443600654602, 0.029657350853085518, 0.6526968479156494, 0.3464861214160919, -0.15688440203666687, -0.01589588075876236, -0.47404944896698, -0.42925766110420227, 0.2811087369918823, -0.4865676462650299, -0.31010934710502625, -0.14983879029750824, 0.5313125252723694, -0.03589741513133049, 0.09951645135879517, -0.19433729350566864, -0.6195428371429443, 0.023385848850011826, -0.15590576827526093, 0.004760641139000654, 0.3010217845439911, -0.2786155045032501, 0.2981550693511963, 0.35941678285598755, 0.25406619906425476, 0.3018994927406311, -0.09615098685026169, -0.5865219831466675, 0.9596023559570312, -0.33820825815200806, 1.2623276710510254, -0.09203634411096573, -0.10076559334993362, 0.9728624820709229, 0.13554708659648895, -0.0467262864112854, -0.31096675992012024, 0.2198290228843689, 0.4921514093875885, -0.31242600083351135, -0.5182904005050659, -0.29038098454475403, 0.0525234155356884, -0.6623907685279846, 0.1471325308084488, -0.20240192115306854, 0.5134865045547485, -0.3119540810585022, -0.09137383848428726, -0.11596433073282242, 0.16272489726543427, -0.4157838821411133, 0.0014141532592475414, 0.10766393691301346, -0.3982353210449219, -0.43139103055000305, 0.5265701413154602, -0.7018213868141174, 0.7307798266410828, 0.4366805851459503, -0.01826966553926468, 0.9776365160942078, 0.2131441831588745, -0.04114942625164986, 0.7008247971534729, -0.2895035445690155, 0.2392769306898117, -0.32629477977752686, 0.1506815105676651, -0.35841864347457886, -0.16020794212818146, 0.37590673565864563, 0.14918257296085358, -0.08386128395795822, 0.16003446280956268, 0.1504480391740799, 0.039729680866003036, 0.30131086707115173, -0.8141463398933411, -0.12493672966957092, 0.022067613899707794, -0.36957842111587524, -0.41228118538856506, -0.10853911936283112, -0.6829089522361755, -0.09880141168832779, -0.03062085434794426, 0.08948206901550293, -0.08323818445205688, -0.4357317388057709, 0.13486412167549133, 0.43898946046829224, 0.18591032922267914, -0.41063982248306274, -0.31703969836235046, -0.6514454483985901, -0.562822163105011, -0.08583170175552368, 0.0617031455039978, 0.14715828001499176, -0.3329848647117615, -0.4300117790699005, -0.5102858543395996, -0.46905478835105896, 1.0167646408081055, 0.6528581976890564, 0.427656888961792, 0.24892045557498932, -0.6176630854606628, -0.07107824087142944, 0.03290218859910965, -0.45986494421958923, -0.2700836658477783, 0.39127594232559204, -0.42283207178115845, -0.08526280522346497, 0.10495179891586304, 0.5634137392044067, 0.8209286332130432, -0.35918426513671875, -0.40577366948127747, 0.27452415227890015, 0.05807467922568321, -0.4615904986858368, -0.38037723302841187, 0.0940396785736084, -0.6642229557037354, 0.03799046203494072, -0.451953649520874, -0.2275109440088272, 0.2675112187862396, -0.286886990070343, 0.1689969152212143, -0.1232101246714592, 0.437766969203949, 0.13685548305511475, -0.4430755376815796, 0.0829116702079773, -0.5184898376464844, -0.35357943177223206, -0.04881490767002106, 0.1905796080827713, -0.20902615785598755, 0.3792994022369385, -5.974419116973877, 0.06820130348205566, -0.18468736112117767, -0.3688168227672577, -0.0627472996711731, 0.007495373487472534, 0.5426100492477417, 0.07539182156324387, 0.16217970848083496, -0.4019469618797302, 0.005516351666301489, 0.41529861092567444, -0.019259344786405563, 0.1369256228208542, -0.023484334349632263, -0.11307544261217117, -0.10252410173416138, -0.18533731997013092, 0.6604556441307068, -0.05415619537234306, 0.5154837369918823, -0.3111763298511505, 0.05801035091280937, 0.4022068977355957, 0.11845303326845169, 0.699844479560852, -0.5078379511833191, 0.005299297161400318, -0.4621293544769287, -0.5798968076705933, -0.04594682902097702, -0.5391058921813965, -0.15896885097026825, -0.1257706731557846, 0.31682756543159485, -0.042507391422986984, -0.27912023663520813, -0.058222696185112, 0.1456952542066574, -0.27760156989097595, 0.45510590076446533, -0.22003938257694244, -0.30828985571861267, -0.2560741901397705, 0.25135499238967896, 0.07860871404409409, -0.1271754652261734, 0.43475857377052307, -0.3177828788757324, 0.6851427555084229, 0.34235695004463196, 0.0945771113038063, 0.7037883996963501, 0.7474881410598755, 0.4089769721031189, 0.29436787962913513, -0.1779600977897644, -0.07876428961753845, -0.6005693078041077, -0.176263228058815, -0.27694210410118103, -0.18909193575382233, -0.16231891512870789, -0.8280666470527649, -0.06221720203757286, 0.07704918831586838, -0.6276140213012695, -0.30006417632102966, 0.3227022886276245, 0.016761109232902527, -0.21336495876312256, 0.35201966762542725, 0.41255760192871094, -0.47158077359199524, 0.5173000693321228, -0.24447192251682281, -0.11474873870611191, 0.18290607631206512, -0.06877969950437546, -0.2999774217605591, -0.47295501828193665, -0.0076983957551419735, -0.3371753990650177, -0.7066425085067749, 0.048112913966178894, -0.9290485382080078, -0.49717140197753906, 0.16948114335536957, 0.18404510617256165, 0.3018592894077301, 0.5213238596916199, -0.1724918931722641, 0.5610107183456421, 0.38162147998809814, 0.4615386426448822, 0.12452419847249985, 0.5093933343887329, 0.525663435459137, 0.6530831456184387, 0.3361564576625824, 0.6747533082962036, -0.07997363060712814, -0.5197162628173828, -1.1030997037887573, -0.5791444778442383, 0.10557842999696732, -0.567086398601532, -0.010117081925272942, 0.4661950469017029, -0.5954548120498657, 0.2022978514432907, -0.23218373954296112, -0.30028221011161804, -0.31489667296409607, 0.6280251741409302, -0.7013777494430542, -0.09326966106891632, 0.3925337493419647, 0.8830981254577637, -0.37612342834472656, 0.2791774868965149, 0.25499996542930603, -0.2012505829334259, 0.495375394821167, 0.3173290491104126, 0.09394930303096771, 0.4466315507888794, 0.7262624502182007, -0.8028154373168945, -0.1712908148765564, 0.5477316975593567, 0.46028390526771545, -0.01106093917042017, -0.008150152862071991, -0.03431409224867821, 0.16137713193893433, -0.5996954441070557, 0.0937187522649765, 0.06634073704481125, 0.029902111738920212, 0.43248075246810913, 0.0403304323554039, 0.19524462521076202, 0.3058680593967438, 0.04535328224301338, 0.03226093947887421, 0.17685674130916595, -0.021852675825357437, 0.10241104662418365, 0.14971113204956055, 0.17776614427566528, 0.06754743307828903, 0.22273395955562592, -0.1671939641237259, -0.2998538613319397, 0.5582854747772217, 0.6090096831321716, 0.20325517654418945, -0.16343404352664948, -0.15784719586372375, 0.2655090391635895, 0.09074489027261734, -0.5161150693893433, -0.002180357463657856, -0.6015273332595825, -0.4291843771934509, 0.008542058058083057, -0.08446672558784485, -0.21668127179145813, 0.4810332655906677, -0.3243667781352997, -0.08142498880624771, 0.20452535152435303, 0.17558498680591583, 0.34268718957901, -0.26273101568222046, -0.2530575692653656, 0.1136535033583641, 0.23604252934455872, 0.5448147058486938, 0.20781303942203522, -0.7679725289344788, -0.2538670301437378, 0.688985288143158, 0.5452697277069092, 0.4524253308773041, -0.2434038370847702, 0.05839842930436134, -0.27531278133392334, -0.32996219396591187, 0.009698432870209217, -0.08712701499462128, 0.1503319889307022, -0.37331950664520264, 0.0831950455904007, -0.05712413042783737, 0.25482797622680664, 0.5020095705986023, 0.16277693212032318, -0.47893229126930237, 0.4374676048755646, 0.349165678024292, -0.41963061690330505, 0.23594488203525543, 0.5746911764144897, -0.2549682855606079, 0.005179675295948982, -0.2379528433084488, 0.03804570809006691, -0.04935966804623604, -0.6965621709823608, -0.43498119711875916, 0.391888827085495, 0.47827503085136414, -0.3475227952003479, 0.08946200460195541, 0.0033888828475028276, -0.3453139066696167, -0.5299952030181885, 0.33080410957336426, 0.20013447105884552, -0.07967114448547363, 0.23008614778518677, 0.007309838198125362, -0.458258718252182, 0.040912386029958725, 0.18067151308059692, -0.9855984449386597, 0.06895148754119873, -0.1519821137189865, 0.1811380833387375, -0.2123958319425583, -0.19197681546211243, -0.4202879071235657, 0.1954551637172699, -0.5078703165054321, -0.05669074133038521, 0.09998953342437744, -0.26854321360588074, 0.4476275146007538, 0.4430845379829407, 0.48774629831314087, -0.5495560765266418, 0.003140418790280819, -0.12210080772638321, 0.23670955002307892, 0.35933637619018555, -0.6164981126785278, -0.43147385120391846, -0.053011104464530945, 0.4498828649520874, -0.2811920642852783, 0.2487340271472931, -0.029621334746479988, 1.2788150310516357, 0.5123752951622009, -0.016776403412222862, -0.6767479181289673, -0.11583837121725082, 0.09607582539319992, -0.24555279314517975, -0.5574083924293518, -0.1158405989408493, -0.04269513115286827, 0.5270258188247681, -0.04827858880162239, -0.23918814957141876, -0.2235115021467209, 0.2344827800989151, -0.16818347573280334, 0.30898720026016235, 0.5143263339996338, 0.8266736268997192, 0.2587711215019226, -0.40775707364082336, 0.3266771733760834, -0.0668054148554802, 0.29991236329078674, -0.021748648956418037, 0.2070324718952179, -0.35071149468421936, -0.17209772765636444, 0.597736656665802, -0.4067806601524353, 0.20138980448246002, -0.3699198067188263, 0.4674426019191742, -0.29169392585754395, 0.09924271702766418, -0.2900145649909973, 0.18348471820354462, -0.2451176643371582, -0.35621941089630127, 0.039600078016519547, 0.22485968470573425, 0.24751780927181244, 0.38170352578163147, 0.4192759394645691, 0.21224500238895416, -0.09315933287143707, -0.7611778378486633, 0.557463526725769, 0.43146151304244995, -0.8747246265411377, 0.25232821702957153, 0.4000447988510132, 0.44495144486427307, 0.019105417653918266, -0.6941477060317993, -0.20874497294425964, 0.3011678457260132, 0.1551646590232849, 0.29774531722068787, 0.11675868183374405, -0.26438790559768677, -0.08858694136142731, -0.3809468150138855, -0.3158416152000427, 0.5065110325813293, 0.14365485310554504, 0.14187897741794586, 0.7560065984725952, 0.20082631707191467, -0.21818655729293823, 0.04232017323374748, 0.18615534901618958, -0.13604861497879028, -0.2670692801475525, 0.06893794983625412, 0.4074850082397461, 0.5057420134544373, 0.21802982687950134, -0.2067653387784958, 0.41352710127830505, 0.29488056898117065, -0.05704629048705101, -0.40130358934402466, -0.20312358438968658, -0.4792236387729645, 0.31751933693885803, 0.7719166278839111, 0.11950713396072388, -0.17818786203861237, 0.02785770408809185, 0.18729205429553986, 0.3943507969379425, -0.0975264310836792, 0.1227184534072876, 0.01800748147070408, -0.07098943740129471, 0.16123823821544647, -0.5280717611312866, -0.42017725110054016, 0.32739168405532837, -0.5689778923988342, -0.059548165649175644, 0.04206324368715286, -0.2502525746822357, -0.2563919126987457, 0.17605838179588318, -0.5722236633300781, 0.3052902817726135, -0.38174349069595337, 0.623335599899292, 0.0725981742143631, 0.09109317511320114, 0.25141626596450806, -0.0041390685364604, 0.14973443746566772, -0.5195059776306152, 0.33196476101875305, 0.01981843262910843, -0.8155816197395325, -0.19471457600593567, -0.4398285746574402, -0.6914495825767517, -0.04870080575346947, 0.026524271816015244, -0.11506164819002151, 0.1128641813993454, -0.47551319003105164, -0.09552391618490219, -0.14560195803642273, -0.6445854902267456, -0.03797184303402901, -0.20481865108013153, -0.1762000471353531, -0.17331740260124207, 0.527653694152832, 0.12559907138347626, 0.7100562453269958, -0.9858773350715637, 0.27715790271759033, 0.22802963852882385, -0.08783327043056488, -0.15732914209365845, 0.0073279645293951035, 0.10858561098575592, 0.32925620675086975, 0.31981950998306274, 0.17896197736263275, -0.11284966766834259, 0.10067281872034073, 0.6953138113021851, -1.1504191160202026, 0.16358597576618195, -0.31550973653793335, -0.5821502208709717, -0.5938858985900879, 0.09981101751327515, 1.0397080183029175, 0.4353708326816559, -0.3464089334011078, 0.5484176278114319, -0.1303931027650833, 0.4106857478618622, 0.29006725549697876, -0.5129525661468506, -0.01029414962977171, -0.28157439827919006, -0.2496655285358429, -0.6176148056983948, 0.43240925669670105, -0.14071886241436005, -0.11435680091381073, -0.08683221787214279, 0.7059035897254944, 0.3217286467552185, -0.08492015302181244, 0.678658664226532, -0.5108575820922852, 0.443830281496048, -0.5177998542785645, 0.15169163048267365, -0.5170713067054749, -0.026178821921348572, 0.15866364538669586, -0.07008160650730133, -0.2841375172138214, -0.14767467975616455, -0.10292547941207886, -0.275797575712204, -0.14896710216999054, 0.07789318263530731, 0.3523625433444977, 0.015621481463313103, 0.10447735339403152, -0.49063363671302795, -0.7803521752357483, 0.09631561487913132, 0.062371641397476196, 0.005402335897088051, 0.3060043156147003, -0.04798782616853714, -0.02803487330675125, 0.05319613590836525, -0.14635106921195984, -0.26556074619293213, 0.1350635290145874, 0.4155628979206085 ]
Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator that represents a promising target for the treatment of several metabolic diseases. Administration of recombinant wild type FGF21 to diabetic animals leads to a dramatic improvement in glycaemia and ameliorates other systemic measures of metabolic health. Here we report the pharmacologic outcomes observed in non-human primates upon administration of a recently described FGF21 analogue, LY2405319 (LY). Diabetic rhesus monkeys were treated subcutaneously with LY once daily for a period of seven weeks. The doses of LY used were 3, 9 and 50 mg/kg each delivered in an escalating fashion with washout measurements taken at 2, 4, 6 and 8 weeks following the final LY dose. LY therapy led to a dramatic and rapid lowering of several important metabolic parameters including glucose, body weight, insulin, cholesterol and triglyceride levels at all doses tested. In addition, we observed favorable changes in circulating profiles of adipokines, with increased adiponectin and reduced leptin indicative of direct FGF21 action on adipose tissue. Importantly, and for the first time we show that FGF21 based therapy has metabolic efficacy in an animal with late stage diabetes. While the glycemic efficacy of LY in this animal was partially attenuated its lipid lowering effect was fully preserved suggesting that FGF21 may be a viable treatment option even in patients with advanced disease progression. These findings support continued exploration of the FGF21 pathway for the treatment of metabolic disease.
[ -0.010249288752675056, 0.007122864481061697, 0.0030765982810407877, 0.0046019526198506355, 0.02157609537243843, -0.01608709804713726, 0.009857231751084328, 0.03614342585206032, -0.006706082262098789, -0.017697283998131752, -0.019963325932621956, 0.008103983476758003, -0.0037710401229560375, 0.014456715434789658, -0.03207498788833618, 0.010758748278021812, -0.026456356048583984, 0.020160533487796783, 0.013553068041801453, 0.034390587359666824, -0.0048272013664245605, -0.00853528268635273, 0.009336814284324646, 0.02835942804813385, 0.010138255544006824, 0.01087203249335289, 0.0210995152592659, 0.005903027020394802, -0.019039886072278023, 0.016278281807899475, -0.0030884388834238052, -0.00471869669854641, 0.01106493640691042, -0.011716211214661598, 0.015461742877960205, -0.00004326482303440571, -0.008822165429592133, 0.0018712531309574842, -0.009364539757370949, -0.004007033072412014, 0.000626996741630137, -0.011094236746430397, 0.003813003422692418, 0.00933876633644104, -0.01001386996358633, -0.00010800408199429512, -0.0026299268938601017, -0.02643476240336895, -0.008084829896688461, 0.010960722342133522, -0.010999351739883423, -0.02736177109181881, -0.018044274300336838, -0.010772716253995895, -0.004757211077958345, -0.013274583965539932, 0.016085084527730942, -0.008666503243148327, -0.008705072104930878, 0.012226812541484833, 0.020396780222654343, -0.006603972986340523, 0.004348923452198505, -0.004006590228527784, -0.00227447971701622, -0.0675501823425293, 0.007457265630364418, 0.018287861719727516, 0.010011722333729267, -0.00518761994317174, -0.014317462220788002, 0.010662112385034561, 0.00869444478303194, -0.029384557157754898, 0.0045632836408913136, -0.039655573666095734, -0.010185322724282742, 0.02860650047659874, 0.0010544024407863617, 0.004674107301980257, -0.024582142010331154, -0.001876996480859816, 0.0038112159818410873, 0.023102160543203354, -0.006256345193833113, 0.015567928552627563, -0.021363377571105957, -0.02586991898715496, 0.00880343746393919, 0.001427773735485971, -0.0016205203719437122, -0.012302221730351448, -0.003131004050374031, 0.001852164976298809, -0.03607138246297836, -0.0026570872869342566, 0.0043674036860466, -0.022568725049495697, 0.03146031126379967, -0.0066703190095722675, -0.01787894032895565, 0.002437481191009283, 0.005568225868046284, -0.007184842135757208, 0.005546454340219498, 0.002652781782671809, 0.0002284962683916092, -0.012635481543838978, 0.0008816826157271862, 0.006614932790398598, -0.012643178924918175, -0.0005779433995485306, 0.011498719453811646, -0.003674505976960063, 0.022711537778377533, 0.023756198585033417, -0.005826225504279137, -0.014858059585094452, 0.010997569188475609, 0.0009558852761983871, 0.02993965707719326, 0.018720420077443123, 0.006731755565851927, -0.0035570506006479263, 0.00808867160230875, -0.018449483439326286, 0.010027363896369934, -0.011302860453724861, -0.014675023034214973, 0.00410899193957448, -0.006988937500864267, -0.0007654991932213306, -0.025053802877664566, -0.01742231659591198, -0.004263512324541807, 0.0014923897106200457, -0.014438269659876823, -0.03280288353562355, -0.02124147117137909, -0.009308605454862118, 0.00006607361137866974, 0.0007070201681926847, 0.003471961012110114, 0.010868517681956291, 0.010585328564047813, 0.0023618803825229406, -0.03261147812008858, -0.0008642022730782628, 0.007393472827970982, -0.0357203409075737, -0.0040507931262254715, -0.018052302300930023, -0.0009184908121824265, -0.0068051014095544815, 0.01627465896308422, -0.011423647403717041, -0.02410663664340973, -0.018336517736315727, 0.017778676003217697, -0.0031601018272340298, -0.009072307497262955, 0.003371879458427429, 0.029881510883569717, 0.007764797192066908, -0.01915082149207592, -0.02618372067809105, -0.004041628912091255, -0.0026653248351067305, -0.0033972859382629395, 0.004478982649743557, -0.004100082907825708, 0.003681186120957136, -0.0011907147709280252, 0.0018585852812975645, -0.007239930797368288, -0.02164449915289879, -0.01304805837571621, 0.007307118736207485, -0.004829430021345615, 0.06739819049835205, -0.00567118264734745, 0.024076376110315323, -0.004208005964756012, -0.0016799084842205048, 0.00047506392002105713, -0.004553457722067833, 0.022438805550336838, -0.004412449896335602, -0.001561532262712717, 0.021880250424146652, 0.02127811498939991, 0.011243421584367752, 0.012746707536280155, 0.015941310673952103, -0.02606537938117981, 0.0021704016253352165, 0.02588638663291931, 0.009202558547258377, 0.013113958761096, -0.0066888039000332355, 0.010216368362307549, 0.0002963452134281397, 0.02589542418718338, -0.01920981891453266, -0.010101077146828175, -0.002319685649126768, -0.035615768283605576, -0.029900621622800827, -0.0035733035765588284, -0.01257344800978899, 0.0004073152085766196, -0.022786853834986687, 0.0006339878309518099, -0.012180608697235584, -0.011354001238942146, -0.001012123073451221, -0.03287070617079735, -0.013612762093544006, 0.03428248316049576, -0.008288946002721786, -0.00010302953887730837, 0.004655434750020504, -0.0227661095559597, -0.007716530002653599, -0.028453432023525238, 0.005722068250179291, 0.011653010733425617, 0.011767935939133167, -0.003703505964949727, 0.009675505571067333, 0.011992801912128925, -0.01771271601319313, -0.013099105097353458, -0.0008306329837068915, 0.007446116767823696, 0.018750030547380447, 0.011785848066210747, -0.020628977566957474, 0.00962266605347395, -0.012783793732523918, 0.003130699973553419, 0.01748334988951683, 0.013364367187023163, -0.01934715174138546, 0.009487040340900421, 0.006078240927308798, 0.019046621397137642, 0.00904545933008194, 0.008997926488518715, -0.01932428777217865, 0.005616811104118824, 0.015254510566592216, -0.02529071271419525, -0.007917474955320358, 0.010037673637270927, -0.008561168797314167, -0.01233565155416727, 0.003831538138911128, 0.020793672651052475, 0.025168895721435547, 0.0040888600051403046, 0.00790637731552124, -0.003621470183134079, 0.009872108697891235, 0.004831490106880665, 0.05371130257844925, 0.007297117728739977, 0.003454641904681921, -0.012151995673775673, 0.008304940536618233, 0.007857785560190678, -0.005989698227494955, -0.00343224685639143, -0.08155520260334015, -0.014207923784852028, -0.036274634301662445, 0.011179463006556034, 0.008742420002818108, 0.0034793701488524675, -0.008814872242510319, -0.01514697540551424, -0.006715433206409216, 0.006489274092018604, 0.009334771893918514, -0.0008898074738681316, -0.010624454356729984, 0.015909310430288315, -0.0077551789581775665, -0.002934597432613373, 0.010898405686020851, -0.003706123447045684, -0.019844766706228256, -0.009538131766021252, -0.0027515932451933622, 0.016130587086081505, 0.04604826122522354, -0.012188620865345001, -0.01930161565542221, -0.005746767856180668, 0.024828067049384117, -0.0061811888590455055, -0.012905362993478775, 0.005447747185826302, -0.0047453902661800385, 0.0013541975058615208, 0.004908990114927292, 0.007395139429718256, 0.0071630412712693214, 0.0038716858252882957, 0.0026018451899290085, -0.010424717329442501, -0.014969371259212494, 0.019859090447425842, -0.00925683043897152, 0.007472565397620201, -0.009426780045032501, -0.010240821167826653, -0.009343880228698254, 0.006274079903960228, -0.010224650613963604, -0.021119222044944763, 0.01328862551599741, 0.01133162435144186, 0.019456785172224045, 0.003379336092621088, -0.0032069715671241283, 0.015331052243709564, -0.028122151270508766, -0.01652463898062706, -0.010858604684472084, 0.009752482175827026, -0.006539883092045784, -0.017063118517398834, 0.013119745999574661, -0.012763762846589088, 0.025637919083237648, 0.013287864625453949, 0.000938845332711935, 0.003558051772415638, 0.013270191848278046, 0.027392249554395676, -0.0071717798709869385, 0.01706564798951149, 0.008764847181737423, -0.0027445354498922825, -0.009292354807257652, -0.010836126282811165, 0.018595505505800247, -0.008613902144134045, -0.017923755571246147, -0.008289081044495106, 0.0254434235394001, -0.012398356571793556, 0.011728985235095024, 0.005821877159178257, -0.004895962309092283, 0.012591049075126648, -0.012142030522227287, -0.01152881607413292, 0.004105139523744583, 0.03783905506134033, 0.0019924393855035305, -0.007635976653546095, -0.0032576913945376873, 0.037873245775699615, 0.00225919671356678, 0.008070021867752075, -0.013458064757287502, 0.012853405438363552, -0.002293854020535946, -0.0035243937745690346, 0.010043598711490631, 0.008644997142255306, -0.0020051132887601852, -0.012712636962532997, 0.012030255049467087, -0.015069108456373215, 0.008369669318199158, 0.008979622274637222, -0.0013839974999427795, -0.0012727954890578985, -0.0019896794110536575, -0.002657898236066103, 0.012000267393887043, 0.01691657304763794, -0.009518373757600784, 0.0180196650326252, 0.00857916846871376, 0.03172484412789345, -0.015681598335504532, 0.015888310968875885, 0.07277818769216537, -0.00044533953769132495, 0.00768591184169054, -0.00466014351695776, 0.012749969959259033, -0.01811404526233673, -0.00023019127547740936, 0.018408508971333504, 0.007187274284660816, -0.02785678207874298, 0.009413710795342922, 0.0068040769547224045, 0.03201323747634888, -0.002529209479689598, -0.01708698831498623, 0.01015403401106596, -0.02189066633582115, -0.025124583393335342, 0.015297891572117805, 0.005343056749552488, -0.0015517689753323793, -0.005515082739293575, 0.012559909373521805, -0.016486678272485733, 0.021065913140773773, -0.04089151322841644, -0.017895765602588654, -0.013409222476184368, -0.0012209825217723846, 0.010845636948943138, -0.0008609341457486153, -0.02761058881878853, -0.01058897003531456, -0.007166347932070494, 0.015972822904586792, 0.008558548986911774, 0.01700436696410179, -0.0020901039242744446, 0.019818125292658806, 0.0041848658584058285, 0.0029890805017203093, -0.0173657163977623, 0.024628743529319763, -0.000028076348826289177, -0.02236250601708889, 0.004850589204579592, 0.04064726084470749, -0.014394287951290607, -0.022418884560465813, 0.019897205755114555, 0.011199882254004478, -0.007252583745867014, 0.009373018518090248, -0.00454122107475996, 0.006966351997107267, -0.03069477528333664, 0.02468811720609665, -0.0037402487359941006, -0.01763015240430832, -0.03145528584718704, -0.013928464613854885, 0.029615331441164017, 0.013835406862199306, 0.013644736260175705, 0.010201144963502884, -0.01888955570757389, 0.039858169853687286, 0.006231280975043774, -0.006487719714641571, 0.005492195952683687, 0.0635269284248352, 0.003986634314060211, -0.006674857810139656, 0.0028751585632562637, -0.002024648245424032, 0.010144086554646492, 0.006010162178426981, 0.022775091230869293, 0.018919875845313072, 0.010841362178325653, -0.012737821787595749, 0.013234550133347511, 0.03339270502328873, -0.036086417734622955, 0.013237969018518925, 0.018140070140361786, 0.004714084789156914, -0.074392169713974, -0.02659229002892971, 0.013843243010342121, -0.005481523461639881, 0.004379416350275278, 0.007586298976093531, -0.020390585064888, -0.025416167452931404, -0.03319482132792473, 0.004506657365709543, 0.015650484710931778, 0.02204739674925804, 0.009378856047987938, 0.006504430435597897, 0.010120658203959465, -0.009984465315937996, -0.022838976234197617, -0.0013360455632209778, -0.006737968418747187, 0.023536913096904755, 0.001728538889437914, -0.0020416281186044216, 0.009440198540687561, -0.006224717944860458, -0.006252112798392773, -0.08173034340143204, -0.02187763713300228, -0.0035145138390362263, -0.02578095905482769, 0.000998283619992435, -0.012206102721393108, 0.0060768998228013515, -0.012470290064811707, -0.01279475074261427, -0.011341397650539875, 0.0004637467209249735, -0.012096120044589043, -0.027361737564206123, -0.005228112451732159, 0.01598672941327095, -0.012292318046092987, 0.009163748472929, 0.01679631695151329, -0.009210778400301933, -0.002882456872612238, -0.005433687008917332, -0.0045693414285779, -0.0038728644140064716, 0.00726790726184845, -0.007845400832593441, -0.01012477744370699, -0.031422145664691925, 0.009843728505074978, 0.008762389421463013, -0.003282558172941208, 0.012921461835503578, 0.016020620241761208, 0.0033630658872425556, -0.008853727951645851, -0.0020278082229197025, -0.001975372200831771, 0.018490711227059364, -0.027396127581596375, -0.02231556549668312, -0.003400607733055949, -0.0010673439828678966, 0.01340123638510704, -0.01182851754128933, 0.008889943361282349, 0.005321082193404436, -0.006167260464280844, 0.00662015937268734, -0.0156464371830225, 0.007290045265108347, -0.003542324062436819, 0.009201462380588055, -0.010836813598871231, -0.0037151696160435677, -0.012377165257930756, -0.02758732996881008, -0.01072833500802517, -0.01119217835366726, 0.01249817293137312, 0.024425750598311424, 0.016495753079652786, -0.0015438934788107872, 0.034594640135765076, 0.013749165460467339, 0.07277123630046844, -0.011327540501952171, -0.0002306927926838398, -0.007760250475257635, -0.0069962842389941216, 0.008685249835252762, -0.023497046902775764, 0.0007156352512538433, -0.00004447938408702612, -0.0006200217176228762, -0.005005130544304848, -0.009676892310380936, -0.0086046252399683, 0.009199166670441628, 0.010623694397509098, 0.011971887201070786, 0.008032971993088722, -0.0029184913728386164, -0.004193989560008049, -0.003985789604485035, 0.0281776562333107, 0.007689444348216057, 0.0053092404268682, 0.005910455249249935, 0.018036965280771255, 0.0017011860618367791, -0.015781812369823456, 0.03042266145348549, -0.006064303684979677, -0.009921243414282799, -0.013928581029176712, -0.002063903957605362, 0.0038487701676785946, -0.005697431042790413, 0.008371353149414062, -0.005742940120398998, -0.01870878040790558, 0.009748214855790138, 0.0020930825266987085, -0.019214510917663574, 0.012048223055899143, 0.0016205059364438057, -0.0037559736520051956, 0.000941938254982233, 0.03424450755119324, -0.03640446811914444, -0.010292368941009045, 0.017838694155216217, -0.007719703484326601, 0.0053155869245529175, -0.021682703867554665, 0.0005822725361213088, -0.001502322033047676, 0.01162007823586464, 0.010327190160751343, -0.0012506572529673576, -0.011663805693387985, 0.0016961534274742007, -0.016428612172603607, -0.006727258674800396, 0.01042275968939066, -0.005379759706556797, 0.027425484731793404, -0.006125548854470253, 0.018640056252479553, -0.024413039907813072, 0.008732955902814865, -0.015242388471961021, -0.039554815739393234, 0.013424227945506573, 0.013763167895376682, 0.005333594977855682, 0.006353977136313915, 0.006687733810395002, 0.003648504614830017, 0.0062090991996228695, -0.007600938435643911, 0.0023536698427051306, 0.018832571804523468, 0.0014022376853972673, -0.01002654992043972, 0.011054904200136662, -0.009687105193734169, -0.030942218378186226, 0.018410589545965195, 0.0013474756851792336, -0.005057753995060921, -0.008104199543595314, -0.0023021032102406025, 0.005737666040658951, 0.0007945224642753601, 0.007358045317232609, 0.0071615311317145824, -0.012917870655655861, 0.007825623266398907, 0.03203718364238739, 0.006648000795394182, 0.009851432405412197, -0.015985975041985512, 0.02313815802335739, 0.033282164484262466, -0.007568211294710636, 0.005600625649094582, -0.01845436915755272, -0.014908477663993835, -0.013637754134833813, 0.0037818672135472298, -0.019546261057257652, 0.032878369092941284, 0.020758984610438347, 0.021512657403945923, 0.009779665619134903, 0.006942418869584799, 0.004906090442091227, -0.001829934073612094, 0.01518320757895708, -0.000061019789427518845, 0.020441444590687752, 0.006893051788210869, -0.016039788722991943, 0.005198163446038961, -0.0019643944688141346, 0.0009748078882694244, 0.02423294261097908, 0.012894513085484505, 0.002527103293687105, -0.005713964346796274, 0.016169751062989235, 0.01781701296567917, -0.005827351473271847, 0.01884963922202587, 0.00798791367560625, -0.003572782501578331, -0.006530786864459515, -0.0010696346871554852, -0.01627141237258911, -0.019803274422883987, 0.0031047705560922623, 0.007188131101429462, -0.012407619506120682, 0.014351356774568558, 0.004945671651512384, 0.008840715512633324, 0.010929279029369354, 0.005572913214564323, -0.0024930716026574373, 0.018281105905771255, 0.03816303610801697, 0.0018645164091140032, -0.023936163634061813, -0.004329480230808258, 0.010592062957584858, -0.010647033341228962, -0.006061392370611429, 0.020256055518984795, 0.010044874623417854, 0.0007441903580911458, -0.027192041277885437, 0.005389370024204254, 0.010308746248483658, 0.0033050556667149067, -0.009954789653420448, 0.0006475963164120913, 0.0009551926050335169, 0.01667289063334465, 0.017771948128938675, -0.004472213797271252, -0.014375615864992142, -0.013962313532829285, 0.01857047714293003, 0.020206116139888763, -0.010613704100251198, -0.014828674495220184, 0.003978309687227011, -0.0018426303286105394, -0.002822781912982464, -0.01308305375277996, 0.001417452236637473, -0.01618078537285328, -0.004695414565503597, -0.0010370027739554644, -0.0004062242805957794, 0.007992494851350784, -0.013358774594962597, -0.005571768619120121, -0.024871153756976128, 0.0008758686017245054, -0.0017248892690986395, -0.0023623881861567497, -0.015105580911040306, -0.008091911673545837, -0.004320926498621702, 0.010060418397188187, 0.024172896519303322, -0.0033879645634442568, -0.006682663224637508, 0.02264290302991867, 0.029796965420246124, 0.0017309559043496847, 0.01775437220931053, 0.020774459466338158, -0.02833360619843006 ]
[ -0.08757825195789337, -0.412489652633667, 0.16305848956108093, -0.18060749769210815, -0.08174174278974533, -0.21283859014511108, 0.15284186601638794, -0.2865050137042999, -0.4507441520690918, -0.09120094776153564, 0.01024173479527235, 0.3004787862300873, -0.6909624934196472, -0.09853389859199524, 0.0658293142914772, 0.5773874521255493, 0.6204451322555542, 0.22948285937309265, -0.07868083566427231, -0.7229617834091187, -0.009510464034974575, -0.21633359789848328, 0.509522557258606, 0.079623743891716, -0.08701040595769882, -0.133774071931839, 0.493686318397522, 0.03714421018958092, 0.6978853940963745, 0.17752240598201752, -0.19601456820964813, 0.8166821599006653, -0.10403420776128769, -0.06957417726516724, -0.3248920142650604, 0.34669727087020874, -0.6832406520843506, -0.07975336164236069, 0.016161322593688965, -0.08745147287845612, -0.02419877238571644, -0.1974741667509079, -0.2517450153827667, 0.6570667624473572, -0.18591590225696564, 0.08549459278583527, -1.2417305707931519, 0.5898139476776123, -0.16434787213802338, 0.1346883326768875, -0.11051137000322342, 0.4647230803966522, 0.22402454912662506, -0.18755073845386505, 0.6308174729347229, 0.06422948837280273, -0.9220158457756042, 0.13364864885807037, 0.33038628101348877, -0.09389299899339676, 0.009967845864593983, -0.1748235523700714, -0.26189562678337097, 0.2067493498325348, -0.316577672958374, 0.49424904584884644, -0.03640281781554222, 0.16844391822814941, -0.6021724343299866, -0.22144892811775208, 0.07153024524450302, -0.3544684648513794, -0.3877525329589844, 0.08009036630392075, 0.3645440638065338, -0.3941630423069, -0.3448549211025238, -0.18508201837539673, 0.1654978096485138, 0.374438613653183, 0.1446758657693863, 0.6095663905143738, 0.6787769198417664, -0.19731122255325317, 0.33931052684783936, 0.3654215633869171, -0.3129136860370636, 0.8478431701660156, -0.42207619547843933, -0.4073115885257721, -0.05488831549882889, 0.20403845608234406, 0.6625273823738098, 0.10470474511384964, 0.028293566778302193, 0.3509085476398468, -0.3923080265522003, -0.11695311218500137, 0.060516297817230225, 0.16197526454925537, 0.1405830830335617, -0.001831150846555829, -0.45060449838638306, -0.6267957091331482, -0.37473446130752563, -0.20041534304618835, -0.2680566608905792, -0.8152683973312378, -0.511249303817749, 0.14242127537727356, -1.1064997911453247, 0.08843547105789185, -0.21510997414588928, -0.5747412443161011, 0.1365572214126587, 0.01124800369143486, 0.2308681309223175, -0.21005384624004364, 0.09795623272657394, 0.43436962366104126, -0.04824743792414665, 1.020837426185608, -0.12130475789308548, 0.7433695197105408, 0.1871279776096344, -0.03623170778155327, 0.2033255398273468, 0.20141905546188354, -0.11526630818843842, 0.5347363352775574, 0.22675563395023346, 0.7737995386123657, -0.6274768710136414, -0.08110815286636353, 0.0444338284432888, -0.04448975250124931, -0.4577808082103729, 0.02947361394762993, 0.040605202317237854, 0.10081963241100311, -0.6817591190338135, -0.11116056889295578, -0.16402295231819153, -0.0492195188999176, 0.2226349115371704, -0.09263087809085846, -0.22350282967090607, 0.13420088589191437, -0.0432216040790081, -0.4106239080429077, -0.017812645062804222, -0.5243918895721436, -0.3987950086593628, 0.2502773404121399, -0.2096477895975113, 0.3262099325656891, -0.05466833710670471, -0.31898924708366394, -0.11113837361335754, 0.13216067850589752, 0.09119830280542374, -0.3352435529232025, -0.2243329882621765, -0.06217949092388153, 0.4854806661605835, 0.14804522693157196, 0.2002737820148468, 0.4876309633255005, 0.2141266167163849, -0.21491236984729767, -0.3187415301799774, -0.3398088216781616, 0.1124294251203537, -0.6377543210983276, 0.14834322035312653, -0.17849434912204742, 0.093512162566185, -0.022682778537273407, 0.12889517843723297, -0.0406411848962307, -0.7943270802497864, -0.24561701714992523, 0.15594038367271423, -0.38710835576057434, 0.28043243288993835, 0.417455792427063, 0.5161636471748352, 0.24795524775981903, 0.5255837440490723, 0.410537987947464, -0.04583578556776047, 0.20905816555023193, 0.7721906900405884, -0.6061131954193115, 1.385177493095398, -0.1992712765932083, -0.35319089889526367, 0.9365257024765015, 0.1875309944152832, -0.17488308250904083, 0.12716101109981537, -0.2679153382778168, 0.5047678351402283, -0.021656261757016182, -0.4458824098110199, 0.09382513165473938, -0.0028175266925245523, -0.181147038936615, -0.05938057228922844, -0.25810205936431885, 0.5560380220413208, -0.32815417647361755, 0.08301208913326263, -0.09405063092708588, 0.22389963269233704, -0.19194020330905914, 0.17002838850021362, 0.17544254660606384, -0.48392054438591003, 0.1695178896188736, 0.3593522906303406, -0.5064411759376526, 0.25761115550994873, 0.6354605555534363, -0.18475961685180664, 0.8460238575935364, 0.35267800092697144, -0.11290506273508072, 0.8883680701255798, -0.10322791337966919, 0.11619553714990616, -0.5249741077423096, -0.047418635338544846, 0.1771441251039505, 0.06951375305652618, 0.0642584040760994, -0.1468236744403839, -0.19807550311088562, 0.07749520242214203, -0.4253326952457428, 0.18057125806808472, 0.4511426091194153, -0.6972979307174683, -0.18888290226459503, 0.041501350700855255, -0.05709037557244301, 0.04234448820352554, 0.11856164038181305, -0.8246800303459167, -0.12141314148902893, 0.29166343808174133, 0.34675461053848267, 0.3377569615840912, -0.005429766606539488, -0.08664436638355255, 0.06614803522825241, -0.3600606322288513, -0.24754542112350464, 0.42778417468070984, -0.4301743805408478, -0.1963939517736435, -0.4902840852737427, -0.017412148416042328, 0.1441815346479416, -0.302009254693985, -0.5387363433837891, -0.6654357314109802, -0.020784184336662292, 0.8681586980819702, 0.6657482981681824, 0.8057288527488708, -0.10242553055286407, -1.0173661708831787, -0.11083533614873886, 0.012303460389375687, -0.5721692442893982, 0.1878572553396225, 0.6838760375976562, -0.5279330611228943, -0.22607699036598206, -0.0613536462187767, 0.527285099029541, 1.323062777519226, -0.1881447732448578, -0.49179399013519287, -0.22590434551239014, -0.26588907837867737, 0.005293414928019047, -0.2682766020298004, -1.0746572017669678, -0.3776850998401642, 0.3947712182998657, -0.2733702063560486, 0.032227590680122375, 0.11200351268053055, 0.3487717807292938, -0.128196120262146, 0.7465091943740845, 0.8093170523643494, 0.08153975754976273, 0.0982910767197609, 0.10382495820522308, -0.027120253071188927, -0.19985821843147278, -0.08801621943712234, 0.41568422317504883, -0.16973525285720825, 0.15315909683704376, -5.821840286254883, 0.39259061217308044, -0.24997518956661224, -0.18848975002765656, 0.13529066741466522, -0.1447429209947586, 0.787761926651001, 0.07532364130020142, 0.276593416929245, 0.11136132478713989, -0.27285119891166687, 0.27531784772872925, 0.04271369054913521, -0.3817572593688965, -0.3909527063369751, 0.17602956295013428, -0.35929161310195923, -0.30309468507766724, 0.583224356174469, 0.14588294923305511, 0.3609888255596161, -0.06292055547237396, -0.3101637363433838, 0.5058422684669495, 0.010671756230294704, 0.09302562475204468, -0.9748656749725342, -0.12206409126520157, -0.02509443834424019, -0.5653434991836548, 0.19778618216514587, -0.5880435705184937, 0.04138841852545738, -0.5142431855201721, 0.46243226528167725, -0.06269362568855286, 0.3555297553539276, 0.1752508282661438, -0.18346275389194489, -0.5863592624664307, 0.125209778547287, 0.2550502121448517, -0.27380838990211487, -0.0561392717063427, 0.33919060230255127, 0.35346880555152893, -0.15871384739875793, 0.26577872037887573, -0.2750878930091858, 0.5038010478019714, -0.0030798879452049732, -0.14342813193798065, -0.19023509323596954, 0.31619808077812195, 0.4698808193206787, 0.40841400623321533, -0.3792702257633209, 0.28153496980667114, -0.11941161006689072, 0.2285589575767517, -0.3033507466316223, 0.11768872290849686, -0.4333212375640869, -0.019899548962712288, -0.014406204223632812, 0.3463236689567566, -0.38098466396331787, -0.32259172201156616, 0.6383084058761597, -0.4493754208087921, -0.07756486535072327, 0.4251105487346649, 0.6869298815727234, -0.5988526344299316, 0.8503974676132202, -0.29055869579315186, -0.2280757576227188, 0.024775944650173187, -0.3046942353248596, 0.34600839018821716, -0.4338485896587372, -0.5041127800941467, -0.23811720311641693, -0.3104311525821686, 0.2995912432670593, 0.0468253418803215, 0.18759706616401672, -0.2704522907733917, -0.2570980191230774, 0.15340156853199005, 0.2638746201992035, -0.3086564540863037, 0.07407203316688538, 0.4712396562099457, -0.2983303964138031, 0.18790455162525177, 0.10461770743131638, 0.8718534111976624, 0.357753187417984, 0.34383833408355713, 0.929927408695221, -0.3166448473930359, -0.1326538324356079, -1.369136929512024, -0.0333063118159771, 0.47079065442085266, -0.3777121901512146, 0.007332941051572561, 0.6360070705413818, -0.5385860800743103, 0.3810219168663025, -0.12594498693943024, -0.5172957181930542, 0.26867276430130005, 1.011299729347229, -0.5015838742256165, -0.10885109007358551, 0.2773527204990387, 0.4539211690425873, -0.479046493768692, 0.19920620322227478, 0.31458064913749695, -0.5644064545631409, -0.2922147512435913, -0.05774342641234398, -0.08373327553272247, -0.14630386233329773, 0.24992726743221283, -0.6046523451805115, -0.2015392929315567, 0.028070546686649323, 0.475751668214798, -0.6383411884307861, 0.08144684880971909, 0.14358513057231903, -0.16859431564807892, -0.7262374758720398, 0.3141247034072876, 0.5999393463134766, -0.05080627277493477, 0.019491586834192276, -0.49826255440711975, 0.13216587901115417, -0.29995620250701904, 0.15351779758930206, 0.39269623160362244, 0.3320832848548889, 0.05040214955806732, -0.5000665187835693, 0.02835107408463955, 0.4421881139278412, -0.23284706473350525, -0.1712075173854828, -0.06672876328229904, -0.39989641308784485, 0.4249859154224396, 0.6663036942481995, -0.016162045300006866, 0.815630316734314, -0.7573447823524475, 0.2245473712682724, 0.2039089798927307, -0.8511066436767578, -0.09989822655916214, 0.03243445232510567, -0.38790950179100037, 0.033125124871730804, -0.29771921038627625, -0.051734790205955505, 0.31564760208129883, -0.5065484046936035, -0.1807621866464615, -0.20801284909248352, -0.01675667054951191, -0.1751636415719986, -0.028353486210107803, -0.46341174840927124, -0.26791322231292725, -0.3285011649131775, 0.5511606931686401, -0.04038605839014053, -0.36750462651252747, -0.20424075424671173, 0.3748546540737152, 0.4861764907836914, -0.26428234577178955, -0.002599659375846386, -0.07011043280363083, -0.11055086553096771, -0.40562015771865845, 0.3210547864437103, 0.3453334867954254, 0.23404552042484283, -0.17584843933582306, 0.18866032361984253, -0.1526625156402588, -0.047549985349178314, 0.7774742245674133, -0.19659404456615448, -0.59892737865448, -0.14903810620307922, 0.40234947204589844, -0.10272489488124847, 0.007691987790167332, 0.3514226973056793, 0.011766405776143074, -0.6302467584609985, 0.055809471756219864, 0.17204275727272034, -0.2881224751472473, -0.14231188595294952, -0.8608289957046509, 0.12323540449142456, -0.16688178479671478, 0.028758451342582703, 0.43373292684555054, -0.17901863157749176, -0.6054304242134094, -0.6659934520721436, 0.22315049171447754, 0.2570421099662781, -0.2844427525997162, 0.44642722606658936, -0.2202427238225937, -0.3045334219932556, 0.13068583607673645, 0.3601308763027191, -0.5967813730239868, 0.2163793444633484, 0.34309396147727966, 0.0007910520071163774, -0.5230700373649597, 0.0461735725402832, 0.278450071811676, -0.5848132967948914, 0.02652513049542904, -0.6407930850982666, -0.02195143699645996, -0.031382206827402115, 0.442141592502594, 0.11554670333862305, 0.39652350544929504, -0.795832633972168, -0.3056660294532776, -0.13160933554172516, -0.3631250858306885, 0.6192659139633179, -0.2977640926837921, -0.12199439853429794, -0.016466941684484482, 0.21670982241630554, -0.3996816575527191, 0.21087370812892914, 0.33314424753189087, 1.108894944190979, -0.42801475524902344, 0.15021148324012756, -0.626069962978363, -0.29120078682899475, 0.08532756567001343, -0.19624456763267517, 0.5420727133750916, -0.22108857333660126, 0.25969189405441284, 0.15343160927295685, -0.2583385407924652, -0.23075439035892487, -1.0950239896774292, 0.44961845874786377, -0.06821925193071365, -0.20131917297840118, 0.0769786611199379, 0.4345867931842804, 0.6220659613609314, -0.3274713158607483, 0.23094002902507782, -0.07734081894159317, 0.02474546618759632, -0.09646084159612656, 0.2125098705291748, -0.3545800447463989, -0.10952562838792801, 0.3798789381980896, -0.5396348237991333, -0.06371249258518219, -0.74971604347229, 0.12464958429336548, -0.6154145002365112, -0.10868547111749649, -0.18286685645580292, -0.2754056751728058, 0.26129084825515747, -0.610741913318634, -0.5353730320930481, 0.021676640957593918, 0.11789437383413315, -0.5542837977409363, -0.45018258690834045, -0.07581502199172974, 0.1895069032907486, -0.7615667581558228, 0.6814770102500916, 0.5203520655632019, -0.21063660085201263, -0.3758288025856018, 0.14783990383148193, 0.4348900318145752, 0.1717880666255951, -0.47803863883018494, 0.030125653371214867, 0.004790269769728184, -0.20077142119407654, 0.13037435710430145, 0.0800476148724556, -0.8085166811943054, 0.526063084602356, -0.1836775839328766, 0.1581151932477951, 0.19561246037483215, 0.3816066086292267, 0.6534371972084045, 0.8391595482826233, 0.5391660928726196, -0.10760895907878876, -0.45487862825393677, 0.6081417798995972, 0.02735247276723385, 0.2418588250875473, 0.2154752016067505, 0.926228404045105, 0.705133855342865, 0.049395602196455, -0.038995105773210526, 1.0493581295013428, 0.8058333992958069, 0.17850689589977264, 0.2986049950122833, 0.013734863139688969, -0.3791864514350891, 0.28644463419914246, 0.735030472278595, 0.5718716382980347, -0.4776758849620819, -0.026355640962719917, 0.5586425065994263, 0.16917811334133148, -0.020959442481398582, 0.035223882645368576, 0.14521878957748413, 0.11637426167726517, 0.40880656242370605, -0.4284060597419739, -0.25928995013237, 0.27468979358673096, -0.49604326486587524, 0.05757784843444824, 0.2983783781528473, -0.3997330963611603, -0.5651692152023315, 0.1515885442495346, -0.05049028992652893, 0.3852546811103821, 0.21596600115299225, 0.8508275151252747, -0.17457839846611023, 0.10100706666707993, 0.21875843405723572, 0.39722537994384766, 0.14748890697956085, -0.0913272425532341, 0.3491923213005066, -0.1371023952960968, -0.12786906957626343, 0.42011401057243347, -0.05089513212442398, 0.1025005578994751, -0.10956194996833801, 0.029073679819703102, -0.08000661432743073, 0.5650473237037659, -0.13768614828586578, 0.676781415939331, -0.3583277761936188, -0.6368078589439392, -0.21181230247020721, -0.7215322256088257, -0.2215215563774109, -0.08715000748634338, 0.20255233347415924, -0.1491275131702423, -0.0910155177116394, -0.7220252752304077, -0.07214721292257309, 0.25515520572662354, 0.21316012740135193, -0.15009479224681854, 0.35578247904777527, 0.4398050308227539, 0.09072753041982651, 0.5214754343032837, -0.14221717417240143, 0.3478592038154602, -0.15976643562316895, 0.3377569019794464, -0.5715839862823486, 0.16976171731948853, -0.5210803151130676, -0.0788884311914444, -0.3592287302017212, 0.02238847315311432, 1.150599479675293, 0.9269613027572632, -0.20095261931419373, 0.20556895434856415, 0.17494288086891174, 0.43473055958747864, 0.49791592359542847, -0.7050585150718689, -0.397371381521225, -0.7368564605712891, -0.08461987972259521, -0.5822554230690002, 0.5680081248283386, 0.008285587653517723, -0.6785259246826172, 0.15347492694854736, 0.28784483671188354, -0.021778395399451256, -0.3583325445652008, 0.14244204759597778, -0.10528253763914108, -0.2479631006717682, -0.32496023178100586, 0.0464361198246479, -0.8676487803459167, 0.2285517454147339, -0.11648055911064148, 0.026310069486498833, -0.4533301889896393, -0.08453395962715149, 0.2010601907968521, 0.23370054364204407, -0.060328032821416855, -0.013723460026085377, 0.155808225274086, -0.21927985548973083, -0.030465058982372284, -0.6430234313011169, -0.5511932373046875, 0.1682737171649933, 0.025719420984387398, -0.11885529011487961, 0.07419171929359436, -0.11601867526769638, 0.24811896681785583, 0.463298499584198, -0.21525290608406067, -0.1398579478263855, -0.2337220460176468, -0.0001136755890911445 ]
Stem cell decline is an important cellular driver of aging-associated pathophysiology in multiple tissues. Epigenetic regulation is central to establishing and maintaining stem cell function, and emerging evidence indicates that epigenetic dysregulation contributes to the altered potential of stem cells during aging. Unlike terminally differentiated cells, the impact of epigenetic dysregulation in stem cells is propagated beyond self; alterations can be heritably transmitted to differentiated progeny, in addition to being perpetuated and amplified within the stem cell pool through self-renewal divisions. This Review focuses on recent studies examining epigenetic regulation of tissue-specific stem cells in homeostasis, aging, and aging-related disease.
[ -0.013396374881267548, 0.010467973537743092, -0.008926531299948692, 0.026491116732358932, 0.028626784682273865, -0.030417636036872864, 0.01275336928665638, 0.006896366365253925, -0.01588285341858864, -0.02754358947277069, -0.013183437287807465, 0.012656602077186108, -0.030826536938548088, 0.03199320286512375, 0.00028129969723522663, 0.030221834778785706, -0.01386334653943777, -0.0003414992243051529, 0.006923694163560867, -0.018117733299732208, -0.008590539917349815, -0.012553430162370205, 0.012166334316134453, -0.04001587629318237, -0.023219512775540352, 0.003553356509655714, 0.02100379392504692, -0.0067626796662807465, -0.018243711441755295, 0.015956535935401917, 0.03155171126127243, 0.0022890642285346985, -0.0022225589491426945, -0.0012146099470555782, -0.0012299844529479742, 0.019796740263700485, 0.006216631270945072, 0.02791767194867134, 0.0006553856655955315, -0.00544410664588213, 0.004743854980915785, -0.013716856017708778, 0.0037551799323409796, 0.004507427103817463, -0.008385895751416683, -0.007695321924984455, 0.0022048461250960827, -0.020729243755340576, -0.0228846687823534, 0.006520564667880535, -0.013970771804451942, -0.029006464406847954, -0.007866762578487396, 0.028390686959028244, -0.007293844595551491, -0.013560837134718895, 0.021740317344665527, 0.00422695092856884, 0.01108991913497448, 0.009285655803978443, 0.00990188680589199, -0.04231511056423187, 0.0159683208912611, 0.010021284222602844, -0.00023933290503919125, -0.06636475026607513, -0.003527385648339987, 0.03545920178294182, -0.00021823961287736893, -0.02993445098400116, -0.021864864975214005, 0.0029410221613943577, -0.020996831357479095, -0.025071846321225166, -0.005048757418990135, -0.0030677118338644505, -0.008986782282590866, 0.04095394164323807, 0.02953970432281494, -0.008632538840174675, -0.013561101630330086, -0.024652380496263504, -0.002912485506385565, 0.02543255314230919, 0.0020605872850865126, 0.006330830976366997, -0.00027918920386582613, -0.005454859230667353, 0.0235080998390913, -0.01845681108534336, -0.007087063044309616, 0.02149929292500019, -0.01828383281826973, -0.02135501429438591, -0.034034404903650284, -0.008756125345826149, -0.020941829308867455, -0.018774015828967094, -0.020281458273530006, 0.008926770649850368, -0.03130330517888069, 0.006472651846706867, 0.013939217664301395, 0.01408747211098671, 0.002914444077759981, 0.007642605807632208, 0.008176674135029316, -0.0023902212269604206, 0.027320556342601776, 0.01478651724755764, -0.00007661350537091494, -0.006503447890281677, 0.024657221511006355, 0.03800047188997269, -0.007882690988481045, 0.01598326675593853, -0.019353196024894714, 0.049402449280023575, 0.020655419677495956, -0.0042108879424631596, -0.01196841150522232, 0.03371770679950714, 0.0007493890589103103, -0.010021226480603218, 0.0036454093642532825, 0.00802803784608841, -0.018529508262872696, 0.003782311687245965, -0.004252438433468342, 0.003652455285191536, -0.008459387347102165, -0.012212371453642845, 0.005736370105296373, 0.008274969644844532, -0.007728764787316322, 0.004532443825155497, -0.03467442840337753, -0.018657051026821136, 0.0004542986862361431, -0.0365518182516098, -0.006170159205794334, 0.003246400970965624, -0.004672694019973278, 0.006777140777558088, 0.007983609102666378, 0.000527448661159724, 0.010286304168403149, -0.009936429560184479, -0.005182787775993347, -0.028647709637880325, 0.0077626872807741165, -0.018127350136637688, -0.0012257539201527834, -0.0163322314620018, 0.015720747411251068, 0.021909702569246292, -0.028767995536327362, 0.010616661980748177, 0.005719832144677639, 0.03860557824373245, -0.023356636986136436, -0.043071188032627106, 0.02208392322063446, 0.009474219754338264, 0.03546459600329399, 0.020521562546491623, 0.01423470489680767, -0.003302535507827997, 0.0029810750856995583, 0.006664029322564602, -0.017517007887363434, 0.006830508820712566, 0.006250104866921902, 0.019687149673700333, 0.020012814551591873, -0.00712177250534296, 0.014148212969303131, 0.010730909183621407, -0.017322542145848274, 0.06655336916446686, -0.002173564163967967, 0.006835700944066048, -0.0038723372854292393, 0.00468812370672822, -0.003863257821649313, 0.02172199636697769, 0.01222209818661213, -0.01091472152620554, 0.023425206542015076, 0.03227284178137779, 0.005557755008339882, 0.020545165985822678, -0.019600585103034973, 0.004327083937823772, -0.03126252442598343, 0.002844922710210085, 0.024041878059506416, 0.003690266516059637, 0.003419090062379837, 0.02110246941447258, 0.03284696489572525, -0.007422887720167637, 0.06210843473672867, 0.011065447703003883, 0.030651241540908813, 0.012076208367943764, -0.024200689047574997, -0.011084971949458122, -0.0001617784146219492, 0.02030768245458603, 0.0047877077013254166, -0.035101518034935, 0.0006985985673964024, -0.01111089438199997, -0.008912209421396255, 0.008873192593455315, 0.00470324233174324, 0.013610491529107094, -0.0037725914735347033, -0.01480687316507101, 0.010081782937049866, 0.017196839675307274, 0.018171070143580437, -0.003755613462999463, 0.013436092995107174, -0.03675754368305206, -0.015503674745559692, 0.015051291324198246, -0.02795344963669777, 0.0026225666515529156, -0.005669320002198219, -0.014105920679867268, -0.013880446553230286, 0.038479458540678024, 0.01775890402495861, 0.027474816888570786, 0.014944963157176971, 0.022424034774303436, 0.021304914727807045, -0.011827966198325157, -0.007817904464900494, 0.0078016407787799835, 0.02034372091293335, -0.003900251816958189, -0.005521748214960098, 0.0318777933716774, -0.024726003408432007, 0.005906588397920132, 0.04071766138076782, -0.018687210977077484, 0.006308075971901417, -0.004831152036786079, -0.0057590799406170845, -0.027420150116086006, 0.03159482032060623, -0.02465193346142769, -0.0010278730187565088, 0.010641612112522125, 0.02519693225622177, -0.017364898696541786, 0.006363996304571629, 0.009546782821416855, -0.01828867383301258, -0.02404070273041725, -0.02389369159936905, -0.00013690534979104996, 0.00467986986041069, -0.0025561898946762085, 0.000265670008957386, -0.0016793725080788136, 0.012612431310117245, -0.0028861635364592075, -0.0020951731130480766, -0.08019186556339264, -0.01267402432858944, 0.014503794722259045, -0.021608775481581688, 0.009912636131048203, -0.012685083784162998, -0.013070590794086456, -0.003890767227858305, -0.021683242172002792, -0.004841195419430733, 0.019802197813987732, -0.009709764271974564, -0.0036873798817396164, -0.03459160029888153, 0.00042756227776408195, -0.011131130158901215, 0.010206993669271469, 0.00405716709792614, -0.020248455926775932, -0.02718283049762249, 0.015238633379340172, -0.023447997868061066, -0.00491982139647007, 0.010551709681749344, -0.003949880599975586, 0.004864826798439026, 0.02155812829732895, -0.012744031846523285, -0.05270208418369293, 0.020840544253587723, -0.03633718565106392, -0.013723009265959263, 0.02418402209877968, 0.014884686097502708, -0.02517402358353138, 0.016557078808546066, 0.011706605553627014, -0.003105339128524065, -0.020265663042664528, 0.05311502143740654, 0.017494969069957733, 0.008093750104308128, 0.007153290323913097, 0.007529807277023792, 0.016121605411171913, -0.010884657502174377, 0.017371054738759995, -0.015577573329210281, 0.018256226554512978, 0.03137780353426933, 0.008219457231462002, 0.012028247117996216, 0.0016328864730894566, 0.016115661710500717, -0.01146551314741373, -0.010850363411009312, -0.015390852466225624, 0.011930597014725208, -0.018438395112752914, -0.010955673642456532, 0.039022013545036316, 0.0027050506323575974, -0.009287791326642036, -0.009892250411212444, 0.05030731111764908, 0.020375583320856094, 0.024322593584656715, -0.00042236223816871643, -0.00827561505138874, 0.01199340634047985, 0.021185562014579773, -0.03293102979660034, 0.0037795663811266422, -0.0036702759098261595, -0.001788831315934658, -0.012440056540071964, -0.012150995433330536, -0.0018836022354662418, 0.00029872823506593704, 0.010182036086916924, -0.009899968281388283, -0.012156141921877861, -0.02960202470421791, 0.0015779288951307535, -0.01928216964006424, -0.02847151830792427, 0.0013419429305940866, 0.04943987354636192, 0.021635547280311584, -0.017381422221660614, -0.010554040782153606, 0.02004321664571762, 0.02218765765428543, 0.008528871461749077, 0.012166137807071209, -0.008542641066014767, -0.010484419763088226, -0.009319288656115532, 0.010398833081126213, 0.011278931051492691, -0.03746843338012695, 0.016219912096858025, 0.01445210911333561, -0.008578376844525337, -0.012030579149723053, 0.01921144500374794, 0.015117448754608631, -0.006721356883645058, 0.008130930364131927, -0.003978941589593887, -0.006110659334808588, 0.03151566535234451, -0.004303134046494961, -0.0004997937940061092, 0.015690773725509644, 0.014085875824093819, -0.00047411612467840314, -0.0036890292540192604, 0.07132910192012787, 0.005161956883966923, -0.01482562255114317, -0.022099008783698082, 0.012233797460794449, -0.015076735056936741, -0.03774729743599892, 0.01431485079228878, -0.03951847553253174, 0.013696564361453056, 0.013500244356691837, 0.021212423220276833, 0.01017194427549839, 0.024414436891674995, -0.02907521091401577, -0.006793685257434845, -0.04072821885347366, -0.00942237675189972, 0.008397297002375126, -0.0008449465967714787, 0.013809249736368656, -0.03453844413161278, -0.02378169819712639, 0.02179769054055214, 0.005136390682309866, -0.038922522217035294, -0.003187922528013587, -0.01050498802214861, -0.0269671231508255, 0.007096681743860245, 0.015012864023447037, -0.015753284096717834, -0.0001726519549265504, 0.02808861806988716, 0.03763773292303085, -0.005793884862214327, 0.017943553626537323, -0.013920646160840988, 0.00030647567473351955, -0.002193169668316841, 0.0061186919920146465, -0.017792779952287674, 0.007011400535702705, 0.011958092451095581, 0.009111783467233181, 0.03353435546159744, 0.0438600517809391, -0.003198424354195595, 0.01449369452893734, -0.006442297250032425, -0.023568708449602127, 0.0021650884300470352, 0.020525122061371803, -0.008456798270344734, -0.0011430763406679034, 0.0033677874598652124, 0.007332937326282263, -0.017059873789548874, 0.005208253860473633, 0.0012939199805259705, -0.012700396589934826, -0.007865642197430134, 0.02381104975938797, -0.038805022835731506, 0.016702743247151375, -0.019102532416582108, -0.007384817115962505, -0.017902396619319916, -0.01692521758377552, 0.013019444420933723, 0.015799695625901222, 0.027036946266889572, -0.024632761254906654, 0.008148747496306896, -0.00647528562694788, 0.022528883069753647, 0.010740588419139385, -0.011454134248197079, 0.018556373193860054, -0.014753792434930801, 0.002147695980966091, 0.021549947559833527, 0.0008142152801156044, 0.0019863350316882133, 0.031962983310222626, -0.011447519063949585, -0.008194313384592533, -0.07369735836982727, -0.022534262388944626, 0.008921092376112938, -0.01708599179983139, -0.000436651986092329, -0.008175084367394447, -0.02050851285457611, -0.0008171442896127701, 0.012909229844808578, -0.003837568685412407, -0.05013922229409218, -0.0063552893698215485, 0.006168707273900509, -0.017498012632131577, 0.01392393372952938, 0.014772387221455574, -0.028065672144293785, 0.009314152412116528, -0.009578952565789223, 0.010434682480990887, 0.03210590407252312, -0.027390629053115845, -0.028795672580599785, 0.015930142253637314, 0.0016925071831792593, -0.08004704117774963, 0.028480011969804764, -0.015021050348877907, 0.000926201231777668, -0.008718404918909073, 0.0003736731596291065, -0.013046806678175926, 0.00404762476682663, -0.0033286516554653645, -0.022543203085660934, 0.0023378985933959484, 0.0017286017537117004, -0.011383739300072193, -0.014589318074285984, -0.0027280645444989204, -0.010767009109258652, 0.0070078750140964985, -0.02245628461241722, -0.003808440174907446, -0.003288895357400179, 0.0013569323346018791, -0.011671721003949642, -0.012566719204187393, -0.02063879370689392, -0.012544531375169754, 0.0012887082993984222, -0.023620547726750374, 0.0046064164489507675, 0.0263143852353096, 0.004338530823588371, -0.008328864350914955, -0.005630167201161385, -0.002863883040845394, -0.0006548790261149406, 0.004136557225137949, -0.013627802953124046, -0.00009772623889148235, 0.00556817976757884, -0.020568404346704483, -0.004956380929797888, -0.005089188925921917, 0.028086815029382706, 0.0023328575771301985, 0.017225876450538635, -0.01333305798470974, -0.01619521901011467, 0.005650368519127369, -0.02004295587539673, 0.009536137804389, -0.018558386713266373, 0.005799724720418453, -0.012672431766986847, 0.011951854452490807, 0.0013568606227636337, -0.00042463652789592743, 0.0201009102165699, -0.013948650099337101, 0.010817458853125572, 0.021740512922406197, 0.0004036304308101535, -0.014574611559510231, -0.014433087781071663, -0.014307219535112381, 0.07121043652296066, 0.013086691498756409, 0.015437817201018333, -0.036371391266584396, 0.010834778659045696, 0.001572781358845532, -0.0043455325067043304, -0.02905270829796791, -0.0038921968080103397, 0.0038316287100315094, 0.0010540075600147247, -0.0033115416299551725, 0.007651025429368019, 0.011182788759469986, 0.01342141255736351, 0.025297611951828003, 0.03333263099193573, 0.010504291392862797, 0.0348135344684124, -0.001456905622035265, 0.020321059972047806, 0.01595204696059227, -0.011409838683903217, -0.011980234645307064, 0.01966579630970955, 0.004850883036851883, -0.011883944272994995, -0.0008379807695746422, -0.00780309084802866, 0.018034886568784714, 0.0006091324612498283, -0.017396319657564163, -0.0010975096374750137, -0.035867299884557724, 0.03610830008983612, 0.023296397179365158, -0.021519239991903305, 0.002269451040774584, -0.03685470297932625, 0.022817224264144897, 0.001151548232883215, 0.0001932715531438589, -0.0017606683541089296, -0.005478291306644678, 0.018430938944220543, 0.0025932807475328445, 0.0021641324274241924, -0.0178251713514328, -0.015305593609809875, 0.015626054257154465, 0.018890775740146637, 0.0038615833036601543, 0.017416534945368767, 0.004729650914669037, 0.006517802365124226, 0.00037646619603037834, -0.02080949768424034, 0.025595679879188538, -0.009660007432103157, -0.03207878768444061, 0.007340813521295786, -0.016385702416300774, 0.0021094398107379675, -0.029299914836883545, -0.021052103489637375, -0.0328432098031044, 0.01972539722919464, -0.023236501961946487, -0.0066225165501236916, 0.02407131902873516, 0.012789946049451828, 0.010689625516533852, 0.010036193765699863, 0.0030145812779664993, 0.010693351738154888, -0.00205769925378263, 0.014767855405807495, 0.01852080225944519, 0.014381226152181625, 0.015390841290354729, -0.014614110812544823, 0.05478021502494812, -0.0005755061283707619, 0.0011604777537286282, -0.013414004817605019, -0.006930775009095669, -0.020762374624609947, -0.0007481237407773733, -0.009418816305696964, 0.011243937537074089, 0.004301454406231642, 0.008533760905265808, 0.00021848967298865318, 0.016586922109127045, 0.010927136056125164, 0.03460732102394104, 0.0280907079577446, -0.002345557324588299, -0.0019395553972572088, -0.0015866239555180073, 0.016840551048517227, 0.008002009242773056, -0.01147308386862278, -0.008776199072599411, -0.016896959394216537, -0.02047150954604149, 0.00908912718296051, 0.00853431411087513, -0.023320410400629044, 0.011680996045470238, 0.005124686285853386, 0.00409734807908535, 0.02787957154214382, -0.00427462812513113, -0.0005237516015768051, -0.016271667554974556, -0.026031669229269028, -0.02628909796476364, 0.0009254510514438152, -0.013959338888525963, 0.0010641776025295258, 0.0002921083942055702, 0.030591048300266266, 0.017697632312774658, -0.0158415287733078, -0.023427793756127357, -0.0177493654191494, -0.002628764370456338, -0.002510051941499114, -0.006643401924520731, 0.01054923702031374, -0.023061007261276245, -0.022518020123243332, 0.016053592786192894, 0.018314912915229797, 0.02550765872001648, -0.011841568164527416, 0.0021192277781665325, -0.009435937739908695, 0.03847191482782364, 0.054843127727508545, -0.017029350623488426, -0.0017940303077921271, 0.012649924494326115, 0.010188465937972069, 0.020946651697158813, 0.0153424721211195, 0.011426077224314213, 0.017483185976743698, -0.0007738852873444557, 0.0009540223982185125, 0.003111364785581827, 0.004782252945005894, -0.008238942362368107, 0.019198838621377945, 0.03169463202357292, 0.024012310430407524, 0.0036189176607877016, -0.010585187934339046, -0.010074993595480919, 0.02930653840303421, 0.008433113805949688, 0.008821920491755009, 0.002925292355939746, 0.013982200995087624, 0.026984162628650665, 0.008877201937139034, 0.011117037385702133, -0.019539108499884605, 0.008091393858194351, 0.005715485662221909, -0.007340200711041689, -0.020774725824594498, 0.003749827854335308, -0.008960187435150146, -0.009748507291078568, 0.012603114359080791, -0.016803793609142303, -0.004836592823266983, 0.0017321431078016758, 0.017310138791799545, -0.02035599946975708, 0.010423469357192516, -0.00998022872954607, -0.014351093210279942, -0.006674108561128378, 0.000574158038944006, 0.00038635567761957645, -0.019014712423086166, -0.017996996641159058, -0.005623752251267433, -0.0340312197804451, 0.012698283419013023, 0.002988931257277727, -0.04641987383365631, -0.006090788170695305, 0.016115915030241013, -0.02089221030473709, 0.02350720949470997, 0.0173625648021698, 0.03652535751461983, 0.0014197409618645906 ]
[ -0.10088896751403809, 0.008177465759217739, 0.07251358777284622, -0.029375484213232994, 0.4140104353427887, 0.40443870425224304, 0.2549377977848053, 0.4135909676551819, -0.08063740283250809, -0.5303082466125488, -0.009803654626011848, 0.08722975850105286, -0.11047965288162231, 0.4628974199295044, -0.4230097830295563, -0.06398081034421921, 0.5795175433158875, 0.3869893252849579, -0.22854100167751312, -0.17294102907180786, -0.7908935546875, -0.26154783368110657, 0.7926142811775208, 0.14041584730148315, -0.23380979895591736, -0.5266056656837463, 0.23523636162281036, -0.37195226550102234, -0.11041641235351562, 0.054655347019433975, -0.4198731482028961, 0.26373523473739624, -0.01058948878198862, -0.24173222482204437, -0.5131436586380005, -0.028931938111782074, -0.15350164473056793, -0.5187875628471375, -0.04671468585729599, 0.2082911729812622, -0.3789043724536896, -0.035629142075777054, -0.1356963813304901, 0.583859920501709, -0.4465159475803375, -0.2771477997303009, -1.5434203147888184, 0.7181859016418457, -0.006678157020360231, 0.012771510519087315, -0.06560587137937546, -0.021375320851802826, 0.12984831631183624, 0.32255488634109497, 0.10117931663990021, -0.15353520214557648, -0.4021426737308502, -0.14965061843395233, 0.20555950701236725, -0.5858126282691956, 0.11207910627126694, -0.2776498794555664, -0.45578819513320923, 0.016746021807193756, -0.18527549505233765, 0.1391666680574417, 0.2935640215873718, 0.07933370023965836, -0.8652662634849548, -0.327266126871109, 0.029169665649533272, -0.29474419355392456, 0.041312798857688904, 0.1127857118844986, -0.21418149769306183, -0.12753203511238098, -0.13685835897922516, -0.020324498414993286, 0.1397145539522171, -0.7410275936126709, 0.3116769790649414, 0.12066681683063507, 0.3926108479499817, -0.19372764229774475, 0.5377927422523499, -0.30246028304100037, 0.07684896141290665, 0.7571777701377869, -0.3016253709793091, -0.17765285074710846, -0.41454365849494934, 0.15571951866149902, 0.5036601424217224, 0.5403614640235901, 0.4043501615524292, 0.5531980991363525, 0.6369262933731079, -0.12288950383663177, -0.18066956102848053, 0.19014288485050201, 0.27921876311302185, 0.10838758200407028, -0.09674501419067383, -0.6328086853027344, -0.045705992728471756, -0.5802789926528931, 0.33713531494140625, 0.14084643125534058, -0.2644527852535248, -0.06757667660713196, -1.0136711597442627, 0.1319374144077301, -0.46493226289749146, 0.18474149703979492, -0.31022852659225464, 0.5725626349449158, -0.000872901058755815, -0.5215177536010742, 0.04549046605825424, -0.25884902477264404, 0.08832117915153503, 1.0443243980407715, -0.2862291634082794, -0.06841463595628738, -0.15692447125911713, 0.26461362838745117, 0.12823019921779633, 0.06620032340288162, -0.4171169698238373, 0.05761251971125603, 0.2345350980758667, 0.5157405734062195, -0.4521304965019226, -0.3129239082336426, 0.3381694257259369, -0.25224751234054565, 0.4682137072086334, 0.2791464328765869, 0.831032931804657, -0.17026259005069733, -0.3026294410228729, -0.7366821765899658, -0.23040251433849335, 0.1391071230173111, 0.13489609956741333, -0.27858954668045044, -0.27916669845581055, -0.2510431110858917, -0.06832419335842133, -0.23314186930656433, 0.35203641653060913, -0.3285435736179352, -0.923738956451416, -0.1110549196600914, 0.17292684316635132, 0.45724329352378845, -0.12270621955394745, -0.39919158816337585, 0.10398995876312256, 0.40385663509368896, 0.5559634566307068, -0.11663403362035751, -0.25116291642189026, -0.11397818475961685, 0.7082030773162842, -0.20127788186073303, 0.39516007900238037, 0.19221170246601105, -0.08664353936910629, 0.12834003567695618, -0.608692467212677, 0.09747366607189178, 0.37136924266815186, -0.6698379516601562, 0.39174163341522217, 0.27415966987609863, 0.02473750337958336, -0.026675935834646225, -0.06567004323005676, 0.018036603927612305, -0.7396950721740723, 0.21610456705093384, 0.39112722873687744, -0.11679964512586594, 0.1311630755662918, -0.2445175051689148, 0.2245955914258957, 0.06711499392986298, 0.028180576860904694, -0.3747212290763855, -0.4716016352176666, -0.425573468208313, 0.7345690131187439, -0.6420574188232422, 1.1654120683670044, -0.4948580265045166, 0.12143874913454056, 0.9854360222816467, -0.12063076347112656, -0.360932856798172, -0.16158626973628998, -0.4860421419143677, 0.3877488374710083, 0.028013568371534348, -0.44717878103256226, 0.0828002393245697, -0.22111375629901886, -0.2805733382701874, 0.4152773320674896, -0.19822612404823303, 0.5114142298698425, -0.6730746626853943, 0.006523746065795422, 0.12043792754411697, 0.22365273535251617, 0.1018856093287468, -0.6424307227134705, -0.6002678275108337, -0.8828535079956055, 0.07628311216831207, 0.12150971591472626, -0.1500890702009201, 0.6006708741188049, 0.8500356078147888, 0.3338477909564972, 0.340005487203598, 0.49719080328941345, -0.23356424272060394, 1.0949724912643433, -0.15716125071048737, 0.4534050524234772, 0.06129792332649231, -0.054516930133104324, -0.14484621584415436, -0.024812845513224602, 0.43877121806144714, -0.008595233783125877, 0.1631832718849182, -0.1654455065727234, -0.408824622631073, -0.1323050558567047, 0.0314985066652298, -0.8773425817489624, 0.3699602484703064, 0.05072809383273125, -0.19948074221611023, -0.38841310143470764, 0.43477746844291687, -1.3140015602111816, -0.2807927429676056, 0.1746053546667099, 0.39243820309638977, 0.3935685455799103, -0.6113924980163574, 0.030292019248008728, -0.13246580958366394, 0.12904863059520721, 0.2201388031244278, 0.13693153858184814, -0.47721582651138306, 0.0024575393181294203, 0.02235039323568344, 0.207975834608078, 0.3499384820461273, -0.07753315567970276, -0.18997828662395477, -0.4933125674724579, -0.7116230130195618, 0.7990373969078064, 0.2861347794532776, 0.751264214515686, 0.10858913511037827, -0.7308505773544312, 0.2908317744731903, -0.5727623105049133, -0.6297739148139954, -0.2791832387447357, 0.33711665868759155, -0.669684648513794, 0.1927245855331421, -0.13340939581394196, 0.8397063612937927, 0.6244199275970459, -0.460581511259079, -0.2649708688259125, 0.07643163204193115, 0.09844125807285309, 0.154002383351326, -0.22969385981559753, 0.0341549851000309, -0.28680768609046936, 0.1338086575269699, -0.056794341653585434, 0.1584533452987671, 0.4020655155181885, 0.03865594416856766, 0.2260385900735855, 0.23591139912605286, 0.7062530517578125, 0.22613346576690674, 0.02897033467888832, 0.07401180267333984, 0.04767967760562897, -0.03357037529349327, -0.5378792881965637, 0.2116023600101471, -0.5091380476951599, 0.2980267107486725, -5.855183124542236, -0.03494764864444733, -0.08085104823112488, -0.4402627944946289, -0.06514526903629303, -0.32491064071655273, 0.7931607961654663, 0.2703157663345337, -0.030979370698332787, -0.007400662638247013, 0.31076860427856445, 0.35398247838020325, -0.1647414267063141, 0.5213295817375183, -0.4406754970550537, -0.10572722554206848, 0.1590028554201126, -0.3075147867202759, 0.14901955425739288, 0.07632192969322205, 0.03490673005580902, -0.39193665981292725, -0.045156776905059814, 0.7771406769752502, 0.036603450775146484, 0.1716236025094986, -0.7387927174568176, -0.07427781820297241, -0.5015153884887695, -0.5569758415222168, 0.06542973965406418, -0.5752525925636292, 0.30207446217536926, -0.28157007694244385, 0.2815161645412445, 0.228207066655159, 0.19665874540805817, 0.2018536627292633, 0.04182049259543419, -0.5738493800163269, 0.25339412689208984, 0.05448480322957039, -0.5319977402687073, 0.4038456380367279, 0.4069661498069763, 0.4949892461299896, 0.32778462767601013, 0.18961702287197113, -0.42554354667663574, 1.038909912109375, 0.16938278079032898, -0.1131533607840538, 0.6716092228889465, 0.5284862518310547, 0.46949881315231323, -0.056556787341833115, -0.13264544308185577, -0.241949200630188, -0.22452843189239502, 0.04467449709773064, -0.28721365332603455, 0.1580011248588562, -0.20126289129257202, -0.4368673264980316, -0.02101917192339897, 0.07405198365449905, -0.6542873978614807, -0.3683265745639801, 0.4470386505126953, -0.45522257685661316, -0.3500600755214691, 0.5787861347198486, 0.5750993490219116, -0.6985406875610352, 0.364848792552948, -0.36235103011131287, 0.07191818207502365, 0.10025475174188614, 0.19327861070632935, -0.27785032987594604, -0.11171098053455353, 0.059788357466459274, -0.11271847784519196, -0.23190338909626007, 0.1762888878583908, -0.10290529578924179, -0.2445620745420456, 0.17300722002983093, -0.12333473563194275, 0.4179416298866272, 0.782757043838501, -0.017921045422554016, 0.1833433359861374, -0.07151218503713608, 0.31663817167282104, 0.8952953219413757, 0.517279326915741, 0.8018977642059326, 0.24222517013549805, 0.06441319733858109, 0.6061007976531982, 0.10694049298763275, -0.205791637301445, -0.5390815138816833, -0.4914839267730713, -0.011418412439525127, -0.5694730877876282, 0.39434120059013367, 0.2524205148220062, -1.1081993579864502, 0.45912665128707886, 0.3018229305744171, -0.4636518657207489, -0.8548191785812378, 0.4132760465145111, 0.10095611214637756, -0.32338738441467285, 0.47083738446235657, 1.241879940032959, -0.18166278302669525, 0.15261788666248322, 0.1715743988752365, -0.5151132345199585, -0.0032060847152024508, 0.12402185797691345, -0.10579574853181839, -0.027734912931919098, 1.1589515209197998, -0.39194774627685547, -0.12129641324281693, 0.36177071928977966, 0.6424568891525269, -0.09547470510005951, 0.08995438367128372, -0.12707605957984924, -0.4882641136646271, 0.026547746732831, 0.3076421320438385, -0.3158051073551178, -0.6395627856254578, 0.40805783867836, -0.2564082443714142, -0.12509840726852417, 0.09667196869850159, 0.38765108585357666, -0.012025752104818821, -0.29581132531166077, 0.32517337799072266, 0.12743036448955536, 0.06776928901672363, -0.09177257865667343, -0.14536738395690918, 0.03525244817137718, -0.26344209909439087, -0.26752084493637085, 0.3897343873977661, 0.2941458523273468, -0.17088425159454346, -0.07241656631231308, -0.42042243480682373, 0.12279534339904785, -0.2450910359621048, -0.7448763847351074, -0.048894695937633514, -0.49353164434432983, 0.2862207889556885, -0.21432390809059143, -0.814742386341095, -0.052947308868169785, 0.3522193729877472, -0.4270307421684265, 0.1671290397644043, -0.5910816192626953, -0.2975713014602661, 0.6364965438842773, -0.6186889410018921, -0.36859822273254395, -0.036875881254673004, 0.1372518390417099, -0.21525810658931732, 0.1494564712047577, -0.600576639175415, -0.3941555917263031, 0.23710599541664124, 0.8365209102630615, 0.029598630964756012, -0.011611633002758026, 0.00599002605304122, -0.5607970356941223, -0.3086629807949066, 0.21234844624996185, -0.08770522475242615, 0.07388492673635483, -0.040159087628126144, 0.049695935100317, 0.2569483816623688, -0.09359009563922882, 0.20288659632205963, 0.19272346794605255, -0.12341485172510147, 0.481318861246109, 0.07932697236537933, -0.3489845097064972, 0.3908551335334778, 0.8546400666236877, -0.17655745148658752, -0.16115175187587738, -0.14640218019485474, -0.3546596169471741, 0.016020309180021286, -0.1064271628856659, -0.5448523759841919, -0.11720150709152222, 0.3150125741958618, -0.04794887825846672, -0.22660797834396362, 0.058183200657367706, -0.6215036511421204, -0.6183510422706604, 0.6057828664779663, 0.534674882888794, 0.07064901292324066, -0.3100569248199463, 0.0296823401004076, -0.7020819187164307, -0.18454612791538239, 0.13869541883468628, -0.5577175617218018, 0.28378376364707947, -0.09058073908090591, -0.16402262449264526, -0.07131980359554291, 0.3597491681575775, -0.31795454025268555, 0.2722730338573456, -0.44004130363464355, 0.12994204461574554, 0.4920210540294647, -0.4873337149620056, 0.5054377913475037, 0.02134166657924652, 0.23238971829414368, -0.3789786994457245, -0.48735716938972473, -0.1698276400566101, 0.24902121722698212, 0.2565358579158783, -0.6889010071754456, -0.45896095037460327, 0.4261617958545685, 0.6292264461517334, -0.03208783268928528, -0.07646220177412033, 0.535298228263855, 0.5210157036781311, 0.06726536899805069, 0.03524436429142952, -0.86925208568573, -0.07596922665834427, 0.07582582533359528, -0.08731512725353241, -0.1539047360420227, 0.3215903341770172, 0.041778989136219025, 0.8055278062820435, -0.06382588297128677, 0.026431526988744736, -0.4026096761226654, 0.6886937618255615, -0.5331600308418274, 0.3614175319671631, -0.1650056093931198, 0.7481064200401306, 0.08514784276485443, -0.1365879774093628, 0.39388203620910645, -0.33935853838920593, 0.15413780510425568, -0.7235729098320007, 0.15863889455795288, -0.01895313709974289, -0.5499151349067688, 0.08841224759817123, -0.3946819007396698, 0.48550185561180115, -0.6842812895774841, 0.7178547382354736, -0.442622572183609, 0.03398623690009117, 0.00008435745985480025, -0.40399590134620667, -0.11545035988092422, -0.4394022524356842, -0.15293747186660767, 0.2502405643463135, 0.3066089153289795, 0.08848948776721954, 0.36799857020378113, -0.20605826377868652, 0.005021420307457447, -0.37592288851737976, 0.22230352461338043, 0.2570230960845947, -0.4388503432273865, 0.042029377073049545, 0.601535439491272, -0.04122241586446762, -0.08986140787601471, -0.5973405241966248, 0.1121828630566597, 0.32812607288360596, 0.06305544823408127, 0.1387481838464737, 0.3666338622570038, 0.1335885375738144, -0.018842384219169617, -0.414130300283432, -0.1969970464706421, 0.2662203907966614, 0.29019415378570557, 0.2011914700269699, 0.8099092841148376, 0.5135791897773743, -0.37141335010528564, 0.02444174513220787, 0.20930936932563782, 0.10602368414402008, 0.19264206290245056, 0.09392832964658737, 0.7612070441246033, 0.6769850850105286, 0.5357685685157776, -0.027074124664068222, 0.9572489261627197, 0.32769450545310974, -0.3045752942562103, 0.3096311390399933, -0.6731104850769043, -0.3610217571258545, -0.021191470324993134, 0.7138919830322266, 0.29815393686294556, -0.08875463902950287, 0.14368605613708496, -0.013040061108767986, 0.5657500624656677, 0.02933337166905403, 0.30725276470184326, -0.23094671964645386, -0.08187879621982574, 0.33839040994644165, -1.025861382484436, -0.5657982230186462, -0.1617053747177124, -0.10066613554954529, -0.2984845042228699, 0.3383529484272003, -0.41928553581237793, -0.05534670501947403, 0.16493193805217743, -0.34510359168052673, 0.19250896573066711, -0.23154893517494202, 0.2405518740415573, 0.22675970196723938, -0.08698686957359314, 0.49922871589660645, 0.14706890285015106, 0.5025267601013184, 0.03099490888416767, 0.044324103742837906, 0.12690101563930511, 0.16828659176826477, -0.011662471108138561, 0.6912528276443481, -0.29505234956741333, 0.36506983637809753, 0.25005120038986206, -0.01868315041065216, 0.40095070004463196, -0.58467036485672, 0.37228140234947205, 0.1796518713235855, -0.15965873003005981, -0.2804819345474243, -0.47489649057388306, -0.25729799270629883, -0.018939387053251266, -0.06329642236232758, 0.10506641864776611, 0.3525708019733429, -0.6621888279914856, 0.04471511021256447, 0.35873204469680786, 0.22293289005756378, -0.05363110452890396, 0.05657660588622093, 0.06889328360557556, 0.0674266666173935, 0.23922228813171387, -0.1450640857219696, 0.16550754010677338, 0.0016415496356785297, 0.6219908595085144, -0.8857093453407288, 0.8339030146598816, -0.08264436572790146, -0.6494184732437134, -0.3369087874889374, 0.3130985200405121, 0.7053280472755432, 0.46391546726226807, -0.28469038009643555, 0.3998889923095703, 0.028094729408621788, 0.23701007664203644, 0.05336376652121544, -0.1938835084438324, -0.6247825026512146, -0.8263310194015503, 0.2966947555541992, -0.6432164907455444, 0.7470797300338745, -0.42608749866485596, -0.3494572341442108, 0.013664601370692253, 0.040423113852739334, 0.29432588815689087, 0.03954453766345978, 0.3155107796192169, -0.530400812625885, 0.015798252075910568, -0.4617847204208374, 0.4868572950363159, -0.508698046207428, 0.041763532906770706, 0.22779728472232819, -0.37490615248680115, -0.10123826563358307, -0.3156884014606476, -0.25368329882621765, -0.3255648910999298, 0.21384140849113464, 0.22611695528030396, 0.38590821623802185, 0.02652030996978283, -0.1946277618408203, -0.5645723938941956, -0.5278993844985962, -0.03745939955115318, 0.059616826474666595, -0.28818395733833313, 0.13262467086315155, 0.18402929604053497, -0.05159027501940727, -0.3038972318172455, -0.13549742102622986, -0.4984508156776428, -0.3434980809688568, -0.03332076594233513 ]
Interactions between hosts and parasites provide an ongoing source of selection that promotes the evolution of a variety of features in the interacting species. Here, we use a genetically explicit mathematical model to explore how patterns of gene expression evolve at genetic loci responsible for host resistance and parasite infection. Our results reveal the striking yet intuitive conclusion that gene expression should evolve along very different trajectories in the two interacting species. Specifically, host resistance loci should frequently evolve to co-express alleles, whereas parasite infection loci should evolve to express only a single allele. This result arises because hosts that co-express resistance alleles are able to recognize and clear a greater diversity of parasite genotypes. By the same token, parasites that co-express antigen or elicitor alleles are more likely to be recognized and cleared by the host, and this favours the expression of only a single allele. Our model provides testable predictions that can help interpret accumulating data on expression levels for genes relevant to host−parasite interactions.
[ 0.005186088848859072, 0.0231446735560894, -0.007430598139762878, 0.019412007182836533, -0.003805046435445547, -0.006624211557209492, 0.012672431766986847, -0.006278812885284424, -0.01671656034886837, -0.01699822023510933, -0.012241636402904987, 0.022858072072267532, -0.0005096400273032486, 0.021894928067922592, -0.003355931956321001, 0.015145178884267807, 0.0009717079810798168, -0.003885168582201004, 0.004671132192015648, -0.005454764235764742, 0.028795097023248672, 0.001902618445456028, 0.011590752750635147, -0.021052967756986618, 0.007121399510651827, -0.006359773222357035, -0.008266208693385124, -0.012409916147589684, -0.025719482451677322, -0.02299962379038334, 0.011147713288664818, 0.006537983659654856, 0.016047878190875053, 0.005188522860407829, -0.0033283066004514694, 0.01487815473228693, -0.003281399141997099, 0.031666677445173264, 0.0132661834359169, -0.004807949531823397, -0.006924823392182589, -0.007480750326067209, 0.005724566988646984, -0.018890367820858955, -0.010125963017344475, 0.02282438799738884, -0.004254455678164959, 0.03653765469789505, -0.012254619970917702, 0.00246802787296474, -0.001982065849006176, -0.01423189789056778, -0.018676474690437317, 0.0013652596389874816, -0.007209012750536203, 0.01798088289797306, 0.022836878895759583, 0.012172408401966095, -0.008193587884306908, 0.028639351949095726, 0.002769089536741376, 0.029787013307213783, 0.011448311619460583, -0.014383384957909584, 0.006176736205816269, -0.06685109436511993, -0.003371958155184984, 0.0019212630577385426, -0.008174290880560875, 0.007701878435909748, -0.004950756207108498, 0.006404178217053413, 0.012646561488509178, -0.008008354343473911, -0.04698793962597847, 0.0038838116452097893, -0.030352666974067688, 0.004246103577315807, 0.025241702795028687, 0.027409689500927925, -0.0075074657797813416, -0.012256169691681862, -0.0011420026421546936, 0.010958515107631683, -0.04046783223748207, 0.016443723812699318, -0.01214023120701313, 0.009443184360861778, 0.003146601840853691, -0.00570208253338933, 0.03303267061710358, -0.016194235533475876, -0.016900133341550827, 0.018150122836232185, -0.0435333326458931, 0.0050023882649838924, -0.020104041323065758, -0.005964796990156174, 0.002894192934036255, 0.010754430666565895, -0.011156474240124226, 0.022141525521874428, 0.025087561458349228, 0.017459746450185776, -0.018896454945206642, 0.01415264792740345, 0.01644047349691391, 0.003093128791078925, 0.025554388761520386, 0.015787240117788315, 0.006187186576426029, 0.008321662433445454, 0.017681878060102463, 0.02166001871228218, 0.008566819131374359, 0.012263166718184948, 0.02646530605852604, 0.0202111154794693, 0.014502249658107758, -0.013060621917247772, -0.009968141093850136, 0.00002458551898598671, 0.0006182162906043231, 0.003973290324211121, 0.008554337546229362, 0.03151427209377289, -0.02340838685631752, 0.0031904049683362246, 0.009664068929851055, 0.012249643914401531, -0.008556661196053028, 0.010724239982664585, -0.007391439750790596, -0.01869778521358967, 0.002919388934969902, -0.0033966205082833767, -0.05195121467113495, 0.01270223781466484, -0.00918721966445446, -0.03153633698821068, -0.013294180855154991, 0.007099406328052282, 0.0003676243359223008, 0.01276430208235979, 0.0055555179715156555, 0.008378995582461357, 0.026974622160196304, 0.0007339509320445359, 0.008918345905840397, -0.004245867487043142, -0.008000406436622143, 0.002527291188016534, 0.01736086793243885, -0.015628155320882797, 0.021947894245386124, 0.017519475892186165, -0.018917841836810112, -0.031325988471508026, -0.0012209357228130102, 0.014354033395648003, -0.025582967326045036, -0.015605686232447624, 0.02279289998114109, 0.010676396079361439, 0.02467038668692112, 0.004950374830514193, -0.01595979370176792, -0.001088136457838118, -0.009173894301056862, 0.007585578132420778, -0.01641615480184555, 0.009252163581550121, 0.017745891585946083, 0.0077890027314424515, 0.0062594846822321415, 0.00860771257430315, 0.033087749034166336, 0.005668725352734327, -0.02502019889652729, 0.06704691797494888, 0.006690540816634893, -0.011182297952473164, -0.01655406504869461, 0.004126878920942545, -0.013315541669726372, 0.020038336515426636, -0.012632301077246666, -0.010297302156686783, 0.0016328361816704273, -0.015544146299362183, -0.028907718136906624, -0.004371286369860172, 0.007041994482278824, -0.006494477856904268, 0.002469634171575308, 0.004838651046156883, 0.010611606761813164, 0.003943213261663914, -0.03077949956059456, 0.003220529993996024, -0.037513017654418945, -0.0376141294836998, 0.06706573069095612, -0.020463570952415466, -0.012398776598274708, 0.022884313017129898, -0.0064042420126497746, -0.007060407195240259, -0.01968938112258911, 0.00628899410367012, 0.025289664044976234, -0.01453858520835638, -0.023548420518636703, -0.003751868149265647, -0.03180817514657974, 0.010451201349496841, -0.003965622745454311, -0.005641925614327192, 0.018140414729714394, -0.015903834253549576, 0.0020995629020035267, 0.006655004806816578, -0.007121540140360594, -0.004349701106548309, 0.0333610475063324, -0.018353130668401718, 0.005364963784813881, 0.0139775350689888, -0.023266972973942757, 0.02143489010632038, 0.012953591533005238, -0.031154077500104904, -0.010262170806527138, 0.053867142647504807, 0.013731962069869041, 0.025684107095003128, 0.01103999838232994, -0.008754046633839607, 0.013375593349337578, -0.001485177082940936, -0.0035844717640429735, -0.006079792510718107, 0.030661817640066147, 0.0003102248883806169, -0.02090056613087654, 0.0028982344083487988, -0.0038150970358401537, 0.008952746167778969, -0.02045854926109314, -0.02637808956205845, 0.00733112171292305, 0.022800210863351822, 0.008538808673620224, -0.032377779483795166, 0.0042314687743783, -0.007330647669732571, -0.019336894154548645, 0.005667650140821934, 0.02618228830397129, -0.007758134976029396, -0.00486461166292429, 0.006678675301373005, -0.012082940898835659, -0.02401994913816452, -0.018006447702646255, 0.05660061538219452, 0.025073541328310966, 0.024310393258929253, -0.008922594599425793, 0.0025682421401143074, 0.005380871240049601, -0.0020599476993083954, 0.0034521911293268204, -0.08114370703697205, -0.013850221410393715, -0.018282873556017876, -0.03243346884846687, 0.009443860501050949, -0.012867346405982971, 0.016234707087278366, 0.02325144037604332, 0.00025883549824357033, 0.016167661175131798, 0.028793949633836746, 0.00513580022379756, -0.008586227893829346, -0.013352561742067337, 0.009721619077026844, -0.009405609220266342, 0.006414892617613077, -0.016226761043071747, -0.006137206684798002, -0.018516970798373222, 0.007098525762557983, -0.025500353425741196, 0.015921300277113914, 0.006526075769215822, 0.006974338088184595, -0.014050187543034554, 0.009221330285072327, -0.003662088420242071, 0.000027379486709833145, 0.005872049368917942, -0.0180188175290823, -0.009381820447742939, 0.03768036514520645, 0.00840818788856268, 0.04427915811538696, -0.023785237222909927, 0.013430641032755375, 0.0072738416492938995, -0.011350942775607109, 0.022329404950141907, -0.0074686529114842415, 0.0024909733328968287, 0.035104669630527496, 0.016544939950108528, 0.01767968386411667, 0.004149409476667643, 0.012888925150036812, 0.004201602190732956, 0.009110500104725361, 0.014144212938845158, 0.017704199999570847, 0.014571860432624817, -0.011155111715197563, 0.0068741231225430965, -0.013509312644600868, 0.013936006464064121, -0.01364135555922985, 0.011376708745956421, -0.012737426906824112, -0.01677115075290203, 0.01713087409734726, 0.019187036901712418, 0.0018275475595146418, -0.012613419443368912, 0.01017499715089798, -0.0008469109889119864, 0.013272830285131931, 0.023746272549033165, 0.0035831169225275517, 0.022123510017991066, 0.017854973673820496, -0.019843917340040207, -0.010057618841528893, -0.006202446296811104, 0.024371890351176262, 0.00035264622420072556, -0.012595023959875107, -0.019349662587046623, 0.019925527274608612, -0.006038032937794924, -0.044590581208467484, 0.00041212153155356646, -0.012815364636480808, -0.009057803079485893, -0.019268352538347244, -0.01769578456878662, 0.007526164874434471, 0.019826149567961693, 0.01502056885510683, -0.01757674291729927, 0.02826641872525215, 0.0068945810198783875, 0.016776541247963905, 0.010550792329013348, -0.011099768802523613, 0.01038537360727787, 0.015583626925945282, 0.005313545931130648, -0.00430694967508316, 0.010409286245703697, -0.017159994691610336, -0.005949417129158974, -0.00192733621224761, -0.00867390539497137, 0.016811564564704895, 0.008417882025241852, 0.01448142621666193, 0.008723813109099865, -0.007819938473403454, -0.009890765883028507, 0.0026236227713525295, 0.004551512189209461, -0.009233567863702774, -0.01570468209683895, 0.01802605390548706, -0.004743807949125767, 0.006494301371276379, -0.021440062671899796, 0.07120147347450256, 0.009242761880159378, 0.009965214878320694, -0.010523938573896885, 0.0009228554554283619, -0.014610339887440205, -0.018727408722043037, -0.004578032065182924, -0.05270551145076752, -0.00007263687439262867, 0.014688926748931408, -0.019577698782086372, -0.052641093730926514, -0.009138987399637699, -0.007197749335318804, -0.02099936455488205, -0.008989423513412476, 0.007598117925226688, -0.010557005181908607, 0.01067432388663292, -0.031746555119752884, -0.009122075513005257, 0.006039077881723642, -0.006223502568900585, -0.01194535568356514, -0.02306623011827469, 0.02537337690591812, -0.01690923608839512, -0.014918483793735504, 0.006402823608368635, 0.004608718678355217, -0.030028516426682472, -0.005031441804021597, -0.0026801186613738537, -0.01493958942592144, 0.0267440527677536, 0.037421464920043945, 0.007381752599030733, 0.0024322564713656902, 0.009441474452614784, 0.00409767497330904, -0.01453307643532753, -0.00821953546255827, 0.02526780217885971, 0.005497736856341362, 0.004685158841311932, 0.015001373365521431, -0.004386019427329302, -0.0027873320505023003, 0.013984566554427147, -0.011645982041954994, 0.029408061876893044, 0.009579000063240528, 0.014525823295116425, 0.01905921846628189, -0.021868303418159485, -0.0011076941154897213, -0.014823096804320812, 0.015975361689925194, 0.010971351526677608, -0.024737782776355743, -0.033721983432769775, -0.003593806643038988, -0.030679890885949135, -0.001152222277596593, -0.020257849246263504, -0.021980473771691322, -0.0071914708241820335, -0.01166150439530611, -0.01120821014046669, 0.015622131526470184, -0.016521941870450974, -0.0066831521689891815, 0.008197970688343048, 0.000055528245866298676, -0.007337573915719986, 0.002558585023507476, -0.022011833265423775, -0.032188594341278076, 0.023666661232709885, -0.010113736614584923, 0.010484916158020496, -0.014243369922041893, -0.0009295754134654999, 0.0051132082007825375, 0.0037624575197696686, -0.002872692421078682, -0.07418526709079742, -0.0032685878686606884, 0.008663746528327465, -0.00683476822450757, 0.015709148719906807, -0.019415324553847313, -0.003180138301104307, 0.00039958395063877106, 0.003276608418673277, -0.013898508623242378, -0.008682334795594215, -0.014605425298213959, 0.04022079333662987, 0.018225830048322678, 0.010438619181513786, 0.02275024726986885, -0.01821020059287548, -0.0017004397232085466, -0.010863739997148514, 0.007412782870233059, 0.018531043082475662, -0.00969649013131857, 0.004685387015342712, 0.0004261685535311699, 0.01200698222965002, -0.08010825514793396, -0.004803299438208342, 0.008427130058407784, -0.0031030867248773575, 0.004976973868906498, -0.016887107864022255, 0.004233407322317362, -0.0013641663827002048, -0.010643325746059418, -0.01667870208621025, -0.0047130403108894825, -0.013695582747459412, 0.009834060445427895, -0.011979540809988976, 0.024246491491794586, -0.004051097668707371, 0.014964735135436058, -0.016457032412290573, 0.023651599884033203, 0.01021973229944706, 0.0067443205043673515, -0.01274480577558279, -0.015120208263397217, 0.002039122860878706, -0.003675195388495922, -0.014873478561639786, -0.024514781311154366, 0.009239883162081242, -0.017416898161172867, -0.007929559797048569, 0.004460273310542107, -0.009926022961735725, -0.01880265772342682, -0.04844813793897629, -0.05403575673699379, -0.020323600620031357, -0.007161278743296862, 0.00003614556044340134, -0.010104728862643242, 0.0076714176684618, -0.004819534253329039, -0.009702345356345177, 0.0016544172540307045, 0.026605498045682907, -0.01179261039942503, 0.010817472822964191, 0.00687006302177906, -0.009316463954746723, 0.011693074367940426, 0.025261569768190384, 0.006879324093461037, -0.02804390713572502, 0.006621898151934147, -0.004055233672261238, -0.001682294998317957, 0.01967471092939377, 0.0027034443337470293, 0.015659768134355545, 0.008645804598927498, 0.00729917548596859, 0.0003710309974849224, -0.003043739590793848, 0.0006860050489194691, 0.0718056932091713, 0.008578291162848473, 0.01897619664669037, -0.008787635713815689, 0.0035526345018297434, -0.003087519435212016, -0.039930541068315506, -0.004944104701280594, -0.009912003763020039, -0.018244870007038116, -0.006235601380467415, -0.02006562612950802, -0.007490140851587057, 0.017381759360432625, 0.04791472852230072, -0.011970525607466698, 0.007655950263142586, 0.025425033643841743, 0.023139584809541702, -0.00572124682366848, 0.0018435409292578697, -0.06701293587684631, -0.0291187334805727, -0.00022079423069953918, 0.01127785723656416, 0.01097852736711502, 0.006621100474148989, 0.004354114644229412, -0.009468236938118935, 0.03365561366081238, 0.0021931370720267296, 0.014622500166296959, 0.00038442923687398434, -0.027401026338338852, 0.032026056200265884, 0.003420162247493863, 0.0020935724023729563, -0.0020067517179995775, -0.006741219200193882, 0.015401656739413738, -0.02242732048034668, 0.005919511895626783, 0.006535229738801718, 0.023059681057929993, 0.025134170427918434, 0.008301613852381706, 0.020510762929916382, -0.011433849111199379, 0.01753363013267517, 0.013142592273652554, 0.009444976225495338, -0.00040761101990938187, -0.002167238388210535, 0.00737285241484642, 0.01306421309709549, -0.027689339593052864, 0.008619694039225578, 0.01920676790177822, -0.024280117824673653, 0.00026729446835815907, -0.009058193303644657, -0.002627526642754674, -0.014303445816040039, -0.015385206788778305, -0.017576277256011963, -0.027006085962057114, 0.01253492385149002, -0.021076541393995285, -0.04532815143465996, 0.019843004643917084, -0.02142234891653061, 0.025999335572123528, 0.008726298809051514, -0.025008758530020714, 0.028518619015812874, 0.023721138015389442, 0.02379576675593853, 0.020329512655735016, 0.007433253340423107, -0.007754643447697163, -0.01283736526966095, 0.00041565229184925556, 0.01580241695046425, 0.0196644589304924, -0.008302528411149979, 0.02438303828239441, 0.008501274511218071, -0.0072782691568136215, -0.0036961366422474384, 0.010720405727624893, 0.022829663008451462, 0.008362946100533009, 0.00433602649718523, 0.006164426915347576, 0.007940433919429779, 0.03598140925168991, -0.0006616613827645779, -0.0011318158358335495, -0.004779665265232325, -0.003012315835803747, -0.0064634885638952255, 0.004266779869794846, 0.020371906459331512, -0.024468563497066498, -0.01158407423645258, -0.01718595065176487, 0.009532331489026546, -0.017726808786392212, -0.013508513569831848, -0.043254051357507706, 0.000964141683652997, -0.0017201313748955727, -0.019749345257878304, -0.007210519630461931, 0.0181885939091444, 0.012156377546489239, -0.005176860373467207, -0.014972800388932228, -0.008891178295016289, -0.007973258383572102, -0.007271675392985344, 0.02212977036833763, 0.011686040088534355, 0.0365155003964901, 0.012925504706799984, -0.050250910222530365, -0.011795159429311752, 0.02912607416510582, -0.021421603858470917, -0.008070949465036392, 0.0012963423505425453, -0.04249522089958191, -0.005258005112409592, 0.01376308873295784, -0.00039712991565465927, 0.00024523818865418434, 0.03272765129804611, 0.017889229580760002, 0.0010513383895158768, -0.010000474750995636, 0.020660221576690674, -0.015071427449584007, -0.0016807315405458212, 0.020529961213469505, 0.008103076368570328, -0.03243851661682129, 0.017128344625234604, 0.008446485735476017, 0.0114176906645298, 0.008799869567155838, -0.0018784103449434042, 0.006140843965113163, -0.009215966798365116, -0.008825196884572506, 0.001420892309397459, 0.012773890048265457, 0.010914834216237068, -0.00526104960590601, -0.014227129518985748, 0.009545911103487015, 0.00646195886656642, -0.03373873606324196, -0.021103065460920334, 0.004578195977956057, -0.0066370731219649315, -0.032086215913295746, -0.0015850693453103304, 0.009693879634141922, -0.01291964016854763, 0.02250165306031704, -0.007376382127404213, -0.01229989156126976, 0.006024134811013937, 0.016729939728975296, -0.026282532140612602, -0.017312685027718544, 0.002844664268195629, 0.03501933440566063, -0.008448371663689613, 0.007046745158731937, 0.007269834168255329, 0.002406883053481579, 0.013961419463157654, -0.005375537555664778, -0.014592589810490608, -0.032222747802734375, -0.0014498737873509526, -0.0012810742482542992, 0.013155614957213402, 0.013171987608075142, 0.014695926569402218, -0.027607355266809464, -0.014263208955526352, 0.006019695661962032, -0.004225205164402723, -0.017003657296299934, -0.015662631019949913, 0.0003536378499120474, 0.009569688700139523, 0.01028207316994667, 0.019923865795135498, -0.006881011184304953 ]
[ 0.2980174422264099, 0.03430822119116783, 0.011856572702527046, 0.11074887216091156, -0.06253975629806519, -0.1369723528623581, 0.24786211550235748, 0.16740790009498596, -0.10698974132537842, -1.1764897108078003, 0.2898326814174652, 0.03212088719010353, -0.7892318964004517, 0.813727855682373, -0.26092857122421265, 0.4764821529388428, 0.1515945941209793, 0.007588802836835384, -0.40204188227653503, -0.006528750061988831, -0.29560917615890503, 0.02772749960422516, 0.18598045408725739, 0.01713917963206768, -0.007582342252135277, -0.1384381204843521, 0.41667208075523376, 0.10534355044364929, 0.37195897102355957, -0.2952456474304199, 0.46112629771232605, 0.5794968008995056, -0.4882727265357971, 0.29238733649253845, -0.6679904460906982, -0.5262085795402527, -0.15677392482757568, -0.08457573503255844, 0.12045202404260635, -0.45808544754981995, 0.06502047926187515, -0.14764761924743652, -0.09165043383836746, 0.3003305494785309, -0.18310600519180298, -0.6455608010292053, -1.2212638854980469, 0.5515689849853516, -0.5692963004112244, -0.35220566391944885, 0.05632499232888222, 0.14726217091083527, 0.6041963696479797, 0.5116828083992004, -0.10220841318368912, 0.1652071624994278, -0.4716866612434387, -0.12581570446491241, 0.21258904039859772, -0.7464783787727356, 0.1358965039253235, 0.3309776782989502, -0.11624249070882797, 0.1336715817451477, -0.32378795742988586, 0.5595030784606934, 0.38597750663757324, -0.21042785048484802, -0.3396453261375427, -0.6753506660461426, -0.1467868983745575, -0.3578784763813019, 0.19021186232566833, 0.52208411693573, -0.2595517933368683, -0.12343848496675491, -0.3866681456565857, -0.17820116877555847, 0.14911049604415894, -0.09018194675445557, -0.38316985964775085, -0.026238948106765747, 0.3839277923107147, -0.7463148236274719, 0.8986982107162476, -0.11184806376695633, 0.010665195994079113, 0.8108915686607361, -0.5823314189910889, 0.24127483367919922, 0.04447580873966217, -0.15824483335018158, 0.5173942446708679, 0.3914128839969635, 0.5732287764549255, 0.2798463702201843, 0.6618083119392395, 0.05966716259717941, 0.46198156476020813, 0.28103235363960266, -0.12357442826032639, -0.05576140433549881, -0.251686155796051, -0.518307626247406, -0.3805849850177765, -0.43137165904045105, -0.449969619512558, -0.9857460260391235, -0.37672850489616394, 0.4852011799812317, -1.1402534246444702, -0.09223354607820511, -0.41908377408981323, -0.0007436792948283255, -0.38961201906204224, -0.08611035346984863, -0.08461078256368637, -0.3092612326145172, 0.04332233592867851, 0.14173844456672668, -0.16664552688598633, 1.0322636365890503, -0.12725748121738434, 0.586986243724823, -0.07545582950115204, -0.09955199062824249, 0.12899629771709442, -0.29020535945892334, -0.7367156744003296, 0.22153067588806152, 0.3593358099460602, 0.8222401738166809, -0.30789074301719666, 0.08718520402908325, 0.28481143712997437, -0.263979971408844, 0.27239906787872314, 0.5682129859924316, -0.0911036878824234, -0.3397027552127838, -0.4823760390281677, -0.9277969002723694, -0.1322660744190216, 0.30538830161094666, -0.019146980717778206, -0.17758698761463165, -0.238885760307312, -0.546883225440979, 0.18600597977638245, -0.44376397132873535, -0.24337008595466614, -0.13949288427829742, -0.5816584229469299, 0.1825624406337738, -0.05318204313516617, 0.49520787596702576, 0.3982817530632019, -0.021026572212576866, 0.6769801378250122, 0.4049462378025055, 0.16271738708019257, 0.20156674087047577, -0.6137654185295105, -0.3620559871196747, 0.1961117684841156, -0.21166302263736725, -0.18036998808383942, 0.7947772741317749, 0.058122631162405014, 0.07289495319128036, -0.559143602848053, 0.09321378916501999, -0.07868968695402145, -0.5523561835289001, 0.05802300199866295, 0.08584528416395187, 0.07283389568328857, -0.25983700156211853, 0.5849702954292297, 0.12671834230422974, -0.3613711893558502, -0.4275486469268799, -0.22212693095207214, -0.21508437395095825, 0.32124730944633484, -0.06534108519554138, -0.05335129424929619, -0.1411195695400238, -0.26368144154548645, 0.0010024604853242636, -0.5247337222099304, -0.20260660350322723, -0.11495921015739441, -0.8138881921768188, 1.084359049797058, -0.22219085693359375, -0.6000253558158875, 1.5343774557113647, 0.4235125780105591, -0.4482914209365845, -0.16463603079319, 0.0016429211245849729, 0.40422922372817993, 0.007441257126629353, -0.6736107468605042, -0.04690632224082947, 0.23105725646018982, -0.4515192210674286, -0.1295304149389267, 0.07364939153194427, 0.37598133087158203, 0.08315210789442062, -0.34057244658470154, -0.3773691952228546, 0.2658880949020386, 0.3172122538089752, -0.597044825553894, -0.048973266035318375, -0.5051153898239136, 0.2673676908016205, 0.8937256932258606, -0.7190343141555786, 0.5381172895431519, 0.9221490025520325, -0.003336881287395954, 0.23485492169857025, 0.6272066831588745, 0.18994107842445374, 0.8437537550926208, -0.2891783118247986, 0.21058493852615356, -0.19476841390132904, 0.6304811835289001, -0.6081767678260803, -0.055099967867136, 0.3797692656517029, 0.23568293452262878, -0.16978934407234192, -0.172319233417511, -0.19716088473796844, 0.024062303826212883, 0.4490491449832916, -0.8563106060028076, 0.3978199064731598, -0.34563469886779785, -0.3653019666671753, -0.2597588002681732, -0.06853245198726654, -0.8548756837844849, 0.12738871574401855, 0.47972792387008667, 0.6743372678756714, 0.7259413003921509, -0.5219938158988953, 0.39261898398399353, -0.23277941346168518, -0.4213297367095947, -0.33036184310913086, 0.12279354780912399, -0.2785080671310425, -0.12360592186450958, 0.035477686673402786, -0.20458422601222992, 0.2404029667377472, -0.15386444330215454, -0.5235133767127991, -0.06463851779699326, -0.8049695491790771, 0.2849232852458954, 0.9207601547241211, 0.9688495397567749, -0.19785375893115997, -0.5333653092384338, -0.05095886439085007, -0.021242767572402954, -0.36650991439819336, 0.04022938758134842, 0.3955664038658142, -0.14718669652938843, -0.32398080825805664, -0.3666429817676544, 0.25236570835113525, 0.5403414368629456, -0.5637383460998535, -0.24622762203216553, -0.5826762318611145, 0.0269002802670002, 0.054456233978271484, -0.9052000045776367, 0.014230497181415558, -0.3064318895339966, 0.3222508728504181, -0.39023804664611816, 0.050568435341119766, -0.02990228682756424, 0.43561190366744995, -0.21841613948345184, 0.31148529052734375, 0.6481817364692688, -0.3313727080821991, 0.19230356812477112, 0.29370906949043274, -0.15132023394107819, 0.005523432977497578, -0.16391083598136902, -0.4745090901851654, -0.41371119022369385, 0.3095821738243103, -5.859807014465332, -0.24720454216003418, 0.35755643248558044, 0.2257656753063202, -0.10994847863912582, -0.04872237890958786, 1.1809173822402954, -0.07550206035375595, 0.26661479473114014, 0.16964498162269592, 0.46207624673843384, 0.3736335337162018, 0.06968837976455688, 0.021189508959650993, -0.09135723114013672, 0.37267160415649414, 0.02823757380247116, -0.1811922788619995, -0.08704493194818497, 0.15284369885921478, -0.03650866821408272, 0.14997796714305878, -0.05802946910262108, 0.3347317576408386, -0.14940671622753143, -0.23563937842845917, -0.9146735072135925, -0.21162191033363342, 0.024327058345079422, 0.094574935734272, -0.3765813410282135, -0.2444642186164856, -0.002264149487018585, -0.4439568817615509, 0.25270548462867737, 0.2501237988471985, -0.18489709496498108, -0.15846161544322968, 0.1723395437002182, -0.4142177402973175, 0.011104061268270016, 0.6978805661201477, 0.07517365366220474, -0.36925169825553894, 0.11714582145214081, -0.1701490581035614, -0.061472829431295395, 0.6077510714530945, -0.49739351868629456, 0.9861612319946289, -0.2938639521598816, 0.11137039214372635, 0.7807122468948364, 0.3892592489719391, 0.25575873255729675, -0.21490567922592163, -0.007007965352386236, -0.34364861249923706, -0.35882019996643066, 0.010952921584248543, -0.19256314635276794, -0.7040784358978271, 0.14789462089538574, -0.27786290645599365, 0.16500507295131683, 0.42885875701904297, -0.8897507786750793, -0.3804207444190979, 0.5319661498069763, -0.28460296988487244, -0.4604649841785431, 0.2295502871274948, 0.38162240386009216, -0.7526209950447083, 0.713493287563324, -0.4769327938556671, -0.3712030351161957, -0.2931331694126129, 0.4866466820240021, -0.443843811750412, -0.311379075050354, -0.36186081171035767, -0.22661547362804413, -0.34020110964775085, 0.21374930441379547, -0.8095858693122864, -0.222538024187088, -0.10027733445167542, -0.4996601641178131, 0.21317245066165924, 0.4351221024990082, 0.08931177854537964, 0.4070783257484436, 0.42037153244018555, 0.6399996280670166, 0.6689201593399048, 0.19671447575092316, 0.45534250140190125, 0.4767386317253113, -0.09779632836580276, 1.0811340808868408, -0.6227058172225952, -0.35164013504981995, -0.37748125195503235, 0.31159308552742004, 0.23555594682693481, -0.12563391029834747, 0.26291173696517944, 0.6444783806800842, -0.4967828392982483, 0.0323118232190609, 0.023620638996362686, -0.8009237051010132, -0.3240230083465576, 0.42851895093917847, -0.2010711431503296, -0.014151559211313725, 0.5137152671813965, 0.6272720694541931, 0.058429088443517685, 0.032935675233602524, 0.5264666676521301, -0.04070856794714928, 0.27960678935050964, 0.14609070122241974, -0.1953810602426529, 0.00368147692643106, 0.19834601879119873, 0.03967975825071335, -0.12691205739974976, 0.16482873260974884, 0.3598504662513733, -0.3645869493484497, -0.32131609320640564, 0.23999466001987457, 0.06252340972423553, 0.15820461511611938, -0.052254147827625275, -0.0320638045668602, -0.5076060891151428, 0.23101337254047394, -0.32660406827926636, -0.21789264678955078, -0.22832420468330383, -0.26870137453079224, 0.24013885855674744, -0.24400107562541962, 0.22847230732440948, 0.031729333102703094, 0.26632270216941833, -0.15063084661960602, -0.23794642090797424, -0.10889199376106262, 0.16634687781333923, -0.3596838712692261, 0.29396721720695496, 0.6084774732589722, 0.06772112846374512, 0.30818837881088257, -0.3218747079372406, 0.036677174270153046, -0.3815430700778961, -0.7133002281188965, 0.39904436469078064, -0.4720328748226166, 0.4901213049888611, -0.43747976422309875, -0.14368455111980438, -0.1228344663977623, 0.09827617555856705, -0.2683679163455963, -0.002625836059451103, -0.3879076838493347, -0.18517327308654785, -0.154661163687706, -0.13443678617477417, -0.5052205324172974, 0.3679341971874237, 0.07307606935501099, 0.11185095459222794, 0.18822982907295227, -0.2156292051076889, -0.4091640114784241, 0.1389925181865692, 0.2633921802043915, -0.06566762179136276, 0.5093225836753845, -0.12679414451122284, -0.006671053357422352, -0.3699437975883484, 0.3396918475627899, 0.5471513867378235, 0.4769462049007416, -0.3053010404109955, 0.34936821460723877, 0.0638045221567154, -0.052079569548368454, -0.1748434603214264, 0.038946621119976044, -0.7379902005195618, 0.316720575094223, 0.6765515208244324, -0.7844581604003906, 0.47299546003341675, -0.2614556550979614, 0.1607740819454193, 0.10019277781248093, -0.21484488248825073, 0.22100701928138733, -0.32423123717308044, -0.5487918853759766, -0.290114164352417, -0.0820663720369339, 0.8494240641593933, -0.2437945455312729, -0.17858722805976868, -0.10242040455341339, -0.6043592691421509, 0.18660594522953033, 1.0036437511444092, 0.2836337685585022, 0.047475967556238174, -0.06772986799478531, -0.12541463971138, -0.4214666485786438, 0.45634475350379944, 0.37867361307144165, -0.5824325680732727, 0.034462425857782364, 0.14099274575710297, 0.06314777582883835, -0.20071004331111908, 0.4549296796321869, 0.3133777379989624, -0.5034274458885193, -0.4614551365375519, 0.1378839910030365, -0.264279305934906, 0.13292579352855682, 0.09382864832878113, 0.3841031789779663, 0.6465966701507568, -0.5405231714248657, -0.31481850147247314, 0.04469731077551842, 0.4491587281227112, 0.4597892761230469, -0.5253285765647888, -0.8182645440101624, -0.6161404252052307, -0.1820516437292099, -0.23597347736358643, -0.2765592038631439, 0.49605244398117065, 0.5652441382408142, -0.08527550101280212, -0.25923189520835876, -0.3416079580783844, 0.33519643545150757, -0.13291364908218384, 0.010232312604784966, -0.10208401829004288, -0.24599634110927582, -0.3592553436756134, 0.2522772550582886, -0.1708817481994629, -0.03159208968281746, -0.15884974598884583, 0.13797730207443237, -0.17887306213378906, 0.5931646227836609, -0.39687129855155945, 0.8908688426017761, 0.5747931003570557, 0.35884326696395874, 0.2843754291534424, -0.439849853515625, 0.22674648463726044, -0.12088663130998611, -0.0974588543176651, 0.022051168605685234, -0.4907819330692291, -0.27225857973098755, -0.358072966337204, 0.6763143539428711, -0.41370856761932373, -0.14724498987197876, -0.6024075150489807, 0.1681954264640808, -0.556799054145813, -0.2024591863155365, -0.09435030072927475, -0.13740932941436768, -0.3700519800186157, 0.3906722366809845, 0.2780771553516388, 0.058798886835575104, 0.015652935951948166, -0.22237302362918854, -0.10960473120212555, -0.7608847618103027, 0.3686549961566925, 0.2921053171157837, -0.6731850504875183, 0.5755816698074341, 0.1295526921749115, 0.2360215187072754, 0.181806281208992, -0.21630246937274933, 0.16885176301002502, 0.4695521295070648, -0.15978184342384338, 0.17079709470272064, 0.010182077996432781, -0.3271319568157196, 0.14019882678985596, 0.2284192144870758, -0.5265019536018372, 0.847166121006012, 0.17016905546188354, 0.3935275077819824, 0.6900153756141663, 0.6951098442077637, -0.0036050055641680956, 0.30231180787086487, 0.545558750629425, 0.00516302976757288, 0.35793617367744446, -0.32441994547843933, 0.2284117341041565, 0.44661203026771545, 0.5040343403816223, -0.30868834257125854, -0.5063572525978088, 0.2706039547920227, -0.02332966960966587, 0.2310781329870224, -0.21482600271701813, -0.24695006012916565, 0.5694389939308167, 0.2995215654373169, 0.39454010128974915, -0.14170725643634796, 0.1869233399629593, -0.10411608219146729, 0.2682167887687683, 0.021289963275194168, 0.47293567657470703, -0.30043309926986694, 0.023338204249739647, 0.47055405378341675, -0.2576321065425873, 0.07872628420591354, -0.005175773985683918, -0.3404109477996826, -0.21476639807224274, 0.46135827898979187, -0.47410374879837036, -0.4472110867500305, 0.10286791622638702, 0.02356557734310627, 0.36507195234298706, -0.12377932667732239, 0.12748971581459045, 0.11825323104858398, -0.006842746399343014, 0.5864773988723755, -0.25583165884017944, 0.2840377688407898, -0.3265416622161865, 0.30935004353523254, 0.009135507978498936, -0.31688356399536133, 0.39736151695251465, -0.04356420412659645, -0.4386240243911743, 0.3355957567691803, 0.37905240058898926, -0.03245289996266365, 0.2539835274219513, -0.08866526931524277, 0.10215336829423904, -0.032402269542217255, -0.5826174020767212, 0.16290616989135742, -0.25678345561027527, -0.2782913148403168, 0.3287390172481537, 0.3399485647678375, 0.20620210468769073, 0.8271368145942688, -0.78010493516922, 0.001996417297050357, 0.3803150951862335, 0.20265328884124756, -0.041013773530721664, 0.16840699315071106, 0.5847182869911194, 0.08820498734712601, 0.012331848032772541, 0.07841292023658752, 0.38226768374443054, -0.0898294597864151, 0.396056592464447, -0.5009609460830688, 0.4428587257862091, -0.5465977191925049, -0.5331439971923828, -0.660203218460083, 0.40702763199806213, 0.8091757297515869, 0.13179241120815277, -0.30653613805770874, 0.016810111701488495, 0.012325248681008816, 0.2374870628118515, -0.0546652227640152, -0.40019741654396057, -0.227512389421463, -0.4811064898967743, 0.024616053327918053, -0.4340396523475647, 0.7590328454971313, -0.002329834271222353, -0.12824805080890656, -0.43986842036247253, 0.10813947767019272, 0.7222915291786194, -0.2267434448003769, 0.7689704298973083, -0.12712550163269043, 0.5294123291969299, -0.301601767539978, 0.05738910287618637, -0.37282630801200867, -0.21265266835689545, -0.27046892046928406, 0.7060114741325378, 0.6813485026359558, -0.13096843659877777, 0.29959380626678467, -0.3117424249649048, 0.13239389657974243, 0.01642119139432907, 0.16014359891414642, 0.003621024312451482, 0.2234019786119461, -0.004529215861111879, -0.5598140954971313, 0.4776184558868408, 0.47147610783576965, -0.5416393876075745, -0.253318190574646, 0.03883548453450203, -0.5431165099143982, 0.20652395486831665, 0.055444277822971344, -0.6210975050926208, -0.18654251098632812, -0.0546594075858593 ]
It was recently demonstrated that interleukin (IL)-23–driven IL-17–producing (ThIL-17) T cells mediate inflammatory pathology in certain autoimmune diseases. We show that the induction of antigen-specific ThIL-17 cells, but not T helper (Th)1 or Th2 cells, by immunization with antigens and adjuvants is abrogated in IL-1 receptor type I–deficient (IL-1RI−/−) mice. Furthermore, the incidence of experimental autoimmune encephalomyelitis (EAE) was significantly lower in IL-1RI−/− compared with wild-type mice, and this correlated with a failure to induce autoantigen-specific ThIL-17 cells, whereas induction of Th1 and Th2 responses was not substantially different. However, EAE was induced in IL-1RI−/− mice by adoptive transfer of autoantigen-specific cells from wild-type mice with EAE. IL-23 alone did not induce IL-17 production by T cells from IL-1RI−/− mice, and IL-23–induced IL-17 production was substantially enhanced by IL-1α or IL-1β, even in the absence of T cell receptor stimulation. We demonstrate essential roles for phosphatidylinositol 3-kinase, nuclear factor κB, and novel protein kinase C isoforms in IL-1– and IL-23–mediated IL-17 production. Tumor necrosis factor α also synergized with IL-23 to enhance IL-17 production, and this was IL-1 dependent. Our findings demonstrate that IL-1 functions upstream of IL-17 to promote pathogenic ThIL-17 cells in EAE.
[ -0.0019851550459861755, 0.0021890862844884396, -0.020167771726846695, 0.0008594478131271899, 0.009202055633068085, 0.02549004927277565, 0.010415461845695972, 0.010409334674477577, -0.011821212247014046, -0.011319722980260849, 0.0005582508747465909, 0.007884370163083076, -0.011923189274966717, 0.014385750517249107, -0.00870019942522049, -0.00842958502471447, -0.025423487648367882, 0.02601918950676918, 0.01271851547062397, -0.018201444298028946, 0.000020952895283699036, -0.005481190513819456, 0.01053063664585352, -0.010199123993515968, 0.021516531705856323, 0.025825627148151398, 0.004063842352479696, -0.010388171300292015, -0.038204822689294815, -0.00007745111361145973, 0.01184155698865652, 0.02432609722018242, 0.027192261070013046, -0.008005918003618717, -0.00587072316557169, -0.0054269954562187195, -0.001478313934057951, 0.02429688349366188, 0.02225268818438053, -0.004308491013944149, 0.01972988434135914, -0.010521110147237778, 0.0032890886068344116, -0.00526838842779398, -0.0055198813788592815, 0.006964098662137985, -0.004925509449094534, -0.0029034134931862354, 0.008710382506251335, 0.004944514483213425, 0.001178958686068654, -0.007383869495242834, -0.012685451656579971, -0.013574836775660515, -0.006164714228361845, 0.010849986225366592, 0.018030967563390732, -0.017597928643226624, 0.0005512498319149017, 0.03810792788863182, 0.0042247651144862175, -0.044672124087810516, 0.020831234753131866, -0.004935239441692829, -0.0013625635765492916, -0.06697458028793335, 0.008751936256885529, -0.01157238706946373, 0.003471165196970105, -0.007531925104558468, -0.006622981280088425, 0.005309101194143295, 0.005619409494102001, -0.01648746058344841, -0.0042104157619178295, 0.000803778413683176, -0.004646664019674063, 0.0391097366809845, 0.03313305228948593, 0.012550169602036476, 0.00609474116936326, -0.014628471806645393, 0.04646322876214981, 0.011958377435803413, 0.0030251387506723404, 0.01767857000231743, -0.009468666277825832, -0.01817455142736435, -0.002022872678935528, -0.011580199934542179, -0.012550616636872292, -0.001987416297197342, -0.028410349041223526, -0.0018291499000042677, -0.004676324315369129, -0.0010625210124999285, -0.005509089678525925, 0.01038365438580513, 0.006656040903180838, -0.018359504640102386, -0.012595750391483307, -0.011243443936109543, 0.015351138077676296, 0.011427105404436588, 0.009928632527589798, 0.0102474894374609, -0.021496398374438286, 0.019445110112428665, 0.038720935583114624, 0.010063073597848415, -0.0015063314931467175, 0.012108751572668552, 0.005083636846393347, 0.03298307955265045, 0.004988050553947687, -0.01894243061542511, -0.01904328167438507, -0.01901441067457199, 0.006667573936283588, -0.008544706739485264, 0.009075679816305637, 0.0019251108169555664, -0.01275357510894537, -0.017206739634275436, -0.003012571483850479, -0.016771867871284485, 0.012064710259437561, 0.000821427209302783, 0.0015649525448679924, 0.0085608446970582, -0.006830047350376844, 0.012775851413607597, 0.01064172200858593, 0.005415145307779312, -0.009561059065163136, 0.005494873505085707, -0.006604974158108234, 0.01902105286717415, -0.025283951312303543, -0.018030183389782906, -0.009396668523550034, 0.011933516710996628, -0.0012524428311735392, 0.004701241850852966, -0.0022687329910695553, 0.014151832088828087, 0.024219177663326263, -0.013140249997377396, 0.010800851508975029, -0.01787412166595459, -0.003558661788702011, -0.00342728104442358, 0.001414542319253087, -0.015895072370767593, -0.01985674723982811, 0.014196931384503841, -0.01872716099023819, -0.023401781916618347, -0.0017301568295806646, 0.018677888438105583, -0.016687892377376556, -0.038101691752672195, 0.027296435087919235, 0.009690911509096622, 0.02509172447025776, 0.016664013266563416, -0.012848259881138802, -0.013193832710385323, 0.0186703372746706, 0.005209734663367271, -0.010462047532200813, -0.028555428609251976, -0.009920533746480942, 0.011799761094152927, 0.0015532895922660828, -0.015341373160481453, 0.012773826718330383, 0.007500504143536091, -0.004996029194444418, 0.06667867302894592, 0.012362375855445862, -0.01900872029364109, 0.02704482525587082, -0.011973295360803604, 0.005963309668004513, 0.012431060895323753, 0.024418571963906288, -0.0014636015985161066, -0.00722849927842617, 0.002632119692862034, -0.012927152216434479, 0.027378011494874954, -0.022992324084043503, -0.0191021915525198, -0.048988621681928635, 0.0021435068920254707, 0.014020759612321854, -0.004220862872898579, 0.008670465089380741, 0.015200995840132236, 0.013327645137906075, -0.017270904034376144, 0.017837919294834137, -0.015344791114330292, 0.004678466822952032, 0.007124622352421284, -0.005381342954933643, -0.015797603875398636, -0.016545061022043228, 0.005186533555388451, 0.009117573499679565, -0.005489264614880085, -0.031026817858219147, -0.008628160692751408, 0.008290027268230915, 0.007697040215134621, -0.0013021811610087752, 0.0006676828488707542, -0.005679779220372438, -0.011991579085588455, -0.00009391293860971928, 0.01339501142501831, -0.01580427773296833, -0.013056086376309395, 0.0095168212428689, -0.012327857315540314, -0.008165954612195492, 0.007002844009548426, 0.0007177253719419241, -0.010743110440671444, -0.020586976781487465, -0.00950220599770546, -0.013819357380270958, 0.0331839919090271, -0.012574661523103714, 0.023783117532730103, 0.012201884761452675, -0.009801452048122883, 0.02499667927622795, -0.012041338719427586, -0.011646726168692112, -0.026074819266796112, 0.04587661474943161, -0.021424680948257446, 0.01391548104584217, 0.001375050749629736, 0.01448995340615511, -0.0023057465441524982, -0.013636814430356026, -0.030693868175148964, 0.006615984253585339, -0.045362114906311035, -0.022635560482740402, -0.02724551036953926, -0.00846550241112709, -0.03239833191037178, 0.011398806236684322, -0.032489653676748276, 0.025728989392518997, -0.008748197928071022, 0.0018294374458491802, 0.002704435493797064, 0.0040852585807442665, 0.013591073453426361, -0.025815166532993317, -0.005680183880031109, -0.010508483275771141, 0.012284541502594948, 0.03504228964447975, -0.024796606972813606, 0.011202151887118816, 0.0017990503692999482, 0.007876968942582607, -0.0816803053021431, -0.009460367262363434, -0.01378367468714714, -0.031100254505872726, 0.001541438978165388, -0.011183126829564571, -0.0009943556506186724, 0.004696595948189497, 0.002305240835994482, 0.006680488586425781, 0.0003716676728799939, -0.00008012191392481327, -0.007951180450618267, -0.017956938594579697, -0.0009292648173868656, -0.009163993410766125, 0.007292300462722778, 0.00912372674793005, -0.016744203865528107, -0.030732449144124985, 0.008663887158036232, -0.017513353377580643, 0.03868837654590607, -0.0014413404278457165, 0.002983798272907734, -0.001897223643027246, 0.011480523273348808, 0.01261182315647602, 0.00119733065366745, -0.004571044351905584, -0.023239292204380035, 0.0027002631686627865, 0.00967671349644661, 0.01226093154400587, 0.025271810591220856, 0.016377875581383705, -0.0012225129175931215, -0.03709875047206879, -0.014460975304245949, 0.004070943221449852, -0.014965183101594448, 0.008799264207482338, 0.022678285837173462, 0.0062632798217237, 0.02766890451312065, 0.012904777191579342, 0.008125316351652145, 0.006232897751033306, 0.021964840590953827, 0.005971825215965509, 0.020970642566680908, 0.0021826219744980335, 0.00837310217320919, 0.027906134724617004, -0.0026919585652649403, -0.03200153633952141, -0.0035377955064177513, 0.0007730321958661079, -0.00711346510797739, -0.009526992216706276, 0.010579721070826054, -0.010786205530166626, 0.030280929058790207, 0.021058637648820877, 0.010964896529912949, 0.03182857483625412, 0.013009674847126007, -0.0029587082099169493, -0.010609021410346031, 0.011590266600251198, -0.025647861883044243, 0.004394480027258396, -0.013444449752569199, -0.012352866120636463, -0.018244564533233643, -0.01077853050082922, -0.013634882867336273, -0.0004332374082878232, -0.006779141258448362, 0.019836626946926117, -0.014800988137722015, -0.004626514855772257, -0.006333339028060436, -0.013371653854846954, -0.021270470693707466, -0.02717309072613716, 0.005043152254074812, 0.04962361603975296, 0.017178336158394814, -0.012818340212106705, 0.020208679139614105, 0.03433185815811157, -0.009856521151959896, 0.013480594381690025, 0.013201703317463398, -0.009338797070086002, -0.03457838296890259, 0.01789812184870243, -0.0066661471500992775, 0.007834238931536674, -0.015676353126764297, -0.004614073317497969, -0.009724948555231094, -0.00023214815882965922, -0.012342287227511406, 0.011929737403988838, 0.0013067127438262105, 0.019120430573821068, -0.024304956197738647, 0.0011298591271042824, 0.020125769078731537, -0.011802362278103828, -0.0009281431557610631, 0.017011988908052444, 0.01418226957321167, -0.015111948363482952, -0.009775509126484394, -0.00659836595878005, 0.07256308197975159, -0.025891775265336037, -0.009919648058712482, -0.012818653136491776, 0.019876673817634583, 0.00393499294295907, -0.02502640336751938, 0.016716139391064644, -0.016763150691986084, -0.005198445171117783, 0.012741790153086185, -0.015264047309756279, -0.0078988466411829, 0.012713941745460033, -0.006765666883438826, -0.010344581678509712, 0.013586899265646935, -0.0386381521821022, 0.045119766145944595, -0.018087925389409065, 0.014305360615253448, -0.013522334396839142, -0.01802660897374153, 0.004406449850648642, 0.027784403413534164, -0.04305719584226608, 0.005036898888647556, -0.01234985888004303, -0.01799609884619713, 0.006930644158273935, -0.01977216824889183, -0.023252110928297043, -0.007715105079114437, 0.005042167380452156, 0.027772286906838417, 0.00892580021172762, 0.02167760580778122, -0.015560103580355644, 0.00712714996188879, -0.013119066134095192, -0.01126091182231903, -0.012344160117208958, 0.019964391365647316, -0.0012924871407449245, -0.006947087123990059, 0.01559910923242569, 0.008988846093416214, -0.009083867073059082, -0.006262914277613163, 0.0010074176825582981, -0.010837835259735584, -0.0013083303347229958, 0.015550252050161362, 0.006704726256430149, 0.0002945538144558668, -0.031630050390958786, 0.034145254641771317, 0.000052174844313412905, 0.0025775711983442307, -0.013683991506695747, -0.01111005712300539, 0.000839969958178699, 0.023956194519996643, -0.022481244057416916, 0.007074700202792883, -0.02082948014140129, -0.004635739140212536, -0.008947155438363552, -0.010710236616432667, -0.031612299382686615, 0.007566001266241074, -0.0154765285551548, -0.003549126209691167, 0.01843385025858879, -0.04256848990917206, 0.0049466476775705814, -0.0116922901943326, -0.02634984254837036, 0.027309497818350792, -0.003937641624361277, -0.010997905395925045, 0.01964227855205536, 0.019920803606510162, -0.009302697144448757, 0.015821468085050583, -0.02160024642944336, -0.002415306866168976, -0.07495421916246414, -0.012100043706595898, -0.0012264547403901815, -0.010782958939671516, -0.0050278641283512115, 0.009634124115109444, -0.0209715086966753, 0.00022169295698404312, -0.014330683276057243, -0.009031698107719421, 0.0043651023879647255, -0.0007201982662081718, -0.01800765097141266, -0.000807451899163425, 0.01358717679977417, -0.005053048953413963, -0.02548646368086338, -0.017233630642294884, -0.013189459219574928, -0.013196069747209549, -0.008843785151839256, -0.042594343423843384, -0.038477711379528046, 0.004153911955654621, 0.0064354813657701015, -0.08110318332910538, 0.017832819372415543, -0.010749883018434048, -0.004868555348366499, 0.0026486990973353386, -0.02200394868850708, 0.007022793870419264, 0.01485547423362732, 0.0001123226247727871, -0.01607169210910797, 0.030721236020326614, 0.008777832612395287, -0.01890389248728752, -0.012005743570625782, -0.010855693370103836, -0.000527713040355593, 0.023538321256637573, 0.006782208103686571, 0.020318057388067245, -0.008535478264093399, -0.0006638863123953342, -0.0075777675956487656, -0.003254386130720377, -0.0038877876941114664, -0.00598346721380949, -0.036712244153022766, -0.02175414189696312, 0.013511205092072487, -0.00734321353957057, -0.012869147583842278, -0.005730357952415943, -0.017817683517932892, -0.014109574258327484, -0.014805641025304794, -0.0033890940248966217, -0.017060326412320137, 0.02588101476430893, -0.011346103623509407, 0.009032967500388622, 0.012426554225385189, -0.010547460056841373, -0.010693579912185669, 0.00017474638298153877, 0.024155637249350548, -0.0004967688582837582, -0.02381589636206627, 0.008309165015816689, -0.009675203822553158, 0.005689864978194237, 0.0027448819018900394, 0.006409787572920322, -0.02081039361655712, 0.0021231744904071093, 0.005609932355582714, 0.01852879859507084, 0.008756565861403942, -0.009642906486988068, 0.011076195165514946, -0.014815393835306168, 0.0020274235866963863, -0.005011399742215872, 0.01063980720937252, 0.01030624657869339, 0.07177184522151947, -0.020026443526148796, 0.03249577060341835, -0.03870388865470886, -0.0011706280056387186, 0.00328223779797554, -0.011432208120822906, -0.017311276867985725, -0.03485851734876633, -0.023397225886583328, -0.011929351836442947, -0.013701478019356728, 0.018986009061336517, 0.01203344576060772, -0.017755066975951195, -0.0026238574646413326, -0.006648006848990917, -0.005790310446172953, -0.01913098432123661, 0.018676746636629105, 0.0009137485176324844, 0.009612384252250195, -0.03587713465094566, -0.02787446603178978, 0.023493781685829163, -0.0014139882987365127, 0.00663343258202076, 0.00023650494404137135, -0.03822498768568039, 0.030520115047693253, -0.00486568920314312, -0.00934162549674511, 0.003855620976537466, -0.00980347953736782, 0.009221440181136131, 0.015346083790063858, -0.00879349373281002, 0.012583177536725998, 0.01729680225253105, 0.0053341807797551155, 0.01536362525075674, -0.0048066736198961735, -0.004306652583181858, -0.0033959506545215845, 0.010568739846348763, -0.010318341664969921, -0.013001173734664917, 0.005369119346141815, 0.009525147266685963, 0.009044557809829712, 0.00422330666333437, 0.0036444796714931726, 0.012653490528464317, -0.011863194406032562, 0.005704907234758139, 0.041906505823135376, -0.0012069391086697578, 0.019479552283883095, -0.01192724984139204, -0.0069822343066334724, -0.004021369386464357, -0.007489071227610111, 0.029759472236037254, -0.021945059299468994, -0.0013856302248314023, -0.009713594801723957, 0.006529437378048897, -0.028854571282863617, -0.017318332567811012, 0.01807381585240364, -0.026409756392240524, 0.0032766773365437984, 0.0068478817120194435, 0.004976272117346525, 0.0364319309592247, 0.025180861353874207, 0.014234719797968864, -0.009698017500340939, -0.005169128067791462, 0.010808312334120274, -0.006382284220308065, 0.0068383971229195595, 0.01626589149236679, 0.013883554376661777, -0.012730554677546024, 0.0038437554612755775, 0.0007213153876364231, 0.02017267420887947, 0.006476879119873047, 0.011147251352667809, 0.009601354598999023, 0.009248899295926094, 0.006366868037730455, 0.011495894752442837, 0.006353744771331549, 0.03415590524673462, 0.00746909761801362, 0.0023474027402698994, -0.01750277914106846, 0.00339589174836874, -0.006021433509886265, -0.007171516306698322, -0.00940471887588501, 0.03135836124420166, -0.01326255314052105, 0.004862304776906967, -0.02377672865986824, 0.00879812240600586, 0.00021873833611607552, 0.01721419207751751, 0.018115244805812836, 0.0005995886167511344, 0.016983039677143097, 0.013986160978674889, 0.0010232727508991957, 0.004242578987032175, -0.0062142638489604, 0.00555048743262887, -0.0038323216140270233, -0.016052205115556717, -0.0049996813759207726, 0.007969211786985397, -0.02043193206191063, 0.02240186184644699, -0.0039508347399532795, 0.002625130582600832, -0.011505890637636185, -0.01073431596159935, 0.02886895462870598, -0.00502947811037302, 0.033405791968107224, 0.005824425257742405, -0.022187482565641403, -0.011936573311686516, 0.02646109089255333, 0.023402340710163116, 0.0015994618879631162, -0.010789073072373867, 0.012103519402444363, 0.014011703431606293, 0.014703433029353619, -0.008727474138140678, -0.0028672553598880768, -0.022815659642219543, 0.00899250153452158, -0.0016051908023655415, 0.0032238573767244816, -0.0005839064251631498, 0.007454229053109884, 0.012709438800811768, 0.007735510356724262, -0.0011684136698022485, 0.011751397512853146, -0.0067601995542645454, 0.03221883624792099, 0.023979898542165756, 0.023160135373473167, 0.008085952140390873, -0.023693043738603592, -0.012760638259351254, 0.002800895366817713, -0.029094811528921127, 0.037716034799814224, -0.0009057649876922369, 0.021377356722950935, -0.0033306623809039593, 0.009165679104626179, 0.02841774933040142, 0.016976449638605118, -0.018320420756936073, 0.018108490854501724, -0.01911381632089615, 0.00803679320961237, 0.018709596246480942, -0.014143258333206177, 0.008726760745048523, -0.0033770552836358547, 0.012583334930241108, 0.022823181003332138, -0.007147848606109619, 0.012169839814305305, -0.01571197807788849, 0.010906628333032131, -0.00747759360820055, 0.012684671208262444, -0.028064485639333725, -0.0004915108438581228, 0.01867065392434597, -0.009084610268473625, -0.013176662847399712, -0.02281879261136055, -0.017504103481769562, -0.007637373171746731, 0.011959828436374664, 0.004884104244410992, 0.005521700251847506, 0.012659129686653614, -0.03860309720039368, 0.005700082518160343, -0.002332019153982401, 0.0062323519960045815, -0.0074962712824344635 ]
[ 0.3011593818664551, 0.11094760149717331, -0.07782265543937683, 0.16288861632347107, -0.10310371220111847, 0.1318703144788742, 0.31176239252090454, -0.371279776096344, -0.27828237414360046, -0.3568113446235657, 0.01879161037504673, 0.38672950863838196, -0.4147496819496155, 0.2828265130519867, 0.041040703654289246, 0.8240709900856018, 0.2672424912452698, 0.610238254070282, -0.5022348165512085, -0.8203432559967041, -0.012809223495423794, -0.47808966040611267, 0.5183688998222351, -0.01898880861699581, -0.11597911268472672, -0.12434981763362885, 0.39249318838119507, -0.271672785282135, 0.3984520137310028, -0.36252084374427795, -0.16290521621704102, 0.5271430611610413, -0.1333511918783188, 0.056322112679481506, -0.5606709718704224, 0.14938928186893463, -0.3009594678878784, -0.1350768804550171, -0.10172875970602036, 0.16100254654884338, -0.4163913428783417, -0.32867345213890076, -0.26032277941703796, 0.7856215834617615, 0.03263260796666145, -0.10423456132411957, -1.5536165237426758, 0.669688880443573, -0.11348550021648407, 0.2849971652030945, 0.12653638422489166, 0.03240096569061279, 0.16619105637073517, 0.2696356773376465, 0.4892784655094147, 0.36829888820648193, -0.6981577277183533, -0.5281338095664978, 0.5340479016304016, -0.3582764267921448, 0.12442053109407425, 0.10444033890962601, -0.1929788440465927, -0.1316237896680832, -0.22395262122154236, 0.8408425450325012, -0.02540413662791252, -0.3857528567314148, -0.4982568621635437, -0.20380572974681854, 0.15531490743160248, -0.46001970767974854, -0.3352683484554291, 0.22809921205043793, 0.015305438078939915, -0.4559831917285919, -0.1761266589164734, -0.3833698630332947, 0.288056343793869, 0.25697916746139526, 0.3282451033592224, -0.04674724116921425, 0.20316417515277863, -0.13824966549873352, 0.3234919309616089, 0.23397794365882874, -0.19362643361091614, 0.5652836561203003, -0.5737608671188354, -0.20991671085357666, 0.037606529891490936, 0.11891350150108337, 0.3292202055454254, 0.5171200037002563, 0.06163577362895012, 0.5395252108573914, 0.16218148171901703, -0.1659424751996994, -0.10295446217060089, 0.2951899766921997, -0.041766513139009476, 0.09635183960199356, -0.2751426100730896, -0.4636969268321991, -0.504587709903717, -0.25603002309799194, -0.1438751220703125, -0.43057936429977417, -0.5330572724342346, -0.027143949642777443, -0.7467319369316101, 0.4640842080116272, -0.3716028332710266, -0.44060853123664856, 0.017323940992355347, 0.02247597649693489, 0.3818340301513672, -0.11256736516952515, 0.3472297191619873, 0.2899203598499298, 0.06605327874422073, 1.5868749618530273, -0.13981162011623383, 0.4253946542739868, -0.355947881937027, -0.01483950950205326, -0.016342276707291603, 0.11018269509077072, -0.04332634061574936, 0.49203965067863464, -0.043490491807460785, 0.7437748312950134, -0.6523706316947937, 0.0304663497954607, -0.003208108013495803, 0.07504814863204956, 0.23854561150074005, 0.0853065773844719, 0.40386322140693665, 0.049251116812229156, -0.8829277753829956, -0.7617886066436768, -0.2659723460674286, -0.041401010006666183, -0.1948038935661316, -0.6278544664382935, -0.3473641276359558, 0.4060191810131073, 0.3266679644584656, 0.019035641103982925, -0.1311776041984558, -0.421622097492218, -0.518510103225708, 0.18124966323375702, -0.10216529667377472, 0.1073477566242218, -0.009307608008384705, -0.5120620131492615, 0.23108361661434174, 0.28472694754600525, 0.48931246995925903, -0.07076923549175262, -0.36763685941696167, 0.1802874356508255, 0.49988460540771484, -0.03403053060173988, 0.07976435869932175, 0.34114569425582886, -0.00422237953171134, -0.21208322048187256, -0.6081447005271912, -0.5174760818481445, -0.08456721156835556, -0.7558028101921082, 0.054155610501766205, -0.03379242122173309, 0.018894242122769356, -0.20814067125320435, 0.05199068412184715, 0.42387253046035767, -0.9180325865745544, -0.2787233591079712, -0.28734272718429565, -0.7427027821540833, 0.40320733189582825, 0.426912784576416, 0.3468296229839325, 0.024132542312145233, -0.043141983449459076, 0.23580549657344818, 0.00570646720007062, -0.3955824077129364, 0.8326904773712158, -0.6447510719299316, 1.3078902959823608, -0.2688283622264862, -0.16040131449699402, 1.1775364875793457, 0.31537723541259766, 0.3295944631099701, -0.1353784203529358, -0.06784830242395401, 0.7206408977508545, -0.24387049674987793, -0.417659729719162, 0.4302212595939636, -0.11928870528936386, -0.08086744695901871, -0.41584470868110657, 0.1337328553199768, 0.40114137530326843, -0.22065456211566925, 0.04890476167201996, -0.1814158409833908, 0.22310657799243927, -0.40933364629745483, -0.1467401534318924, -0.01968972198665142, -0.5614116787910461, -0.07015475630760193, 0.11326853930950165, -0.6940380930900574, 0.4922884404659271, 1.050004243850708, -0.19332489371299744, 0.6849197745323181, 0.3426764905452728, 0.07500513643026352, 0.8983084559440613, -0.5792390704154968, 0.2788039743900299, -0.28081417083740234, 0.29352477192878723, -0.5101377367973328, -0.1536102592945099, 0.2677406668663025, 0.038149893283843994, -0.1546117067337036, -0.07337329536676407, 0.15930835902690887, -0.15753300487995148, 0.8027037382125854, -0.4146840572357178, 0.023714272305369377, 0.026076605543494225, -0.3126222789287567, -0.10157056897878647, 0.5094338655471802, -0.935138463973999, -0.10824001580476761, 0.13311031460762024, -0.2544373869895935, 0.43456488847732544, -0.7188119292259216, -0.0125387879088521, 0.11490481346845627, -0.1985638588666916, -0.3069544732570648, -0.1516273021697998, -0.3422803580760956, 0.01014325488358736, 0.11533348262310028, 0.07383380085229874, 0.09085386246442795, 0.4243848919868469, -0.4279751479625702, -0.9842659831047058, -0.1805420219898224, 0.8781411051750183, 0.4166710376739502, 1.2744475603103638, -0.12270737439393997, -0.6286457777023315, 0.054425790905952454, 0.13485263288021088, -0.19572244584560394, -0.4747803807258606, 0.8133805990219116, -0.80633145570755, -0.04792322218418121, -0.09233146160840988, 0.3598068654537201, 0.7496166229248047, -0.1863141804933548, -0.5303200483322144, 0.36738741397857666, -0.3014981150627136, -0.6089631915092468, -0.431876003742218, -0.5244374871253967, 0.38980549573898315, 0.5018843412399292, 0.1205887496471405, 0.17301076650619507, 0.4550653398036957, 0.02569112740457058, -0.10098293423652649, 0.6616045832633972, 0.5988932251930237, -0.07681254297494888, -0.0880281999707222, 0.39479583501815796, -0.48054933547973633, -0.15387018024921417, -0.0857418030500412, 0.061766210943460464, -0.40975111722946167, 0.38765954971313477, -5.9048614501953125, -0.15494678914546967, -0.23559409379959106, -0.026828669011592865, -0.21717485785484314, -0.1644795835018158, 1.2326810359954834, 0.011339451186358929, 0.2576304078102112, 0.45284903049468994, 0.4054216742515564, 0.3955742120742798, 0.09067119657993317, -0.1023310050368309, -0.39295122027397156, 0.2256295382976532, -0.046070702373981476, -0.35621997714042664, 0.7638069987297058, -0.10439133644104004, 0.02019958384335041, -0.0270000658929348, -0.37251734733581543, 0.5790598392486572, 0.17694807052612305, -0.3919408321380615, -1.0577791929244995, 0.07136630266904831, 0.07540605962276459, -0.28278687596321106, 0.3412507474422455, -0.42294901609420776, -0.13437308371067047, -0.3216671049594879, 0.13290637731552124, -0.07846957445144653, 0.10078690201044083, -0.1300256997346878, -0.4472160041332245, -0.4392843544483185, 0.14458952844142914, -0.15482394397258759, -0.23930391669273376, -0.10668259114027023, 0.004632462747395039, -0.38095200061798096, 0.049067288637161255, 0.23923999071121216, -0.058127060532569885, 0.5441768765449524, -0.13727574050426483, -0.10556769371032715, 0.5996820330619812, 0.847380518913269, 0.47081276774406433, 0.0118391839787364, 0.002040374791249633, 0.22481264173984528, -0.4836082458496094, 0.12551885843276978, -0.41471347212791443, -0.05972331389784813, -0.24688297510147095, -0.5917683243751526, 0.13916617631912231, 0.3215687870979309, -0.2731724977493286, -0.4423961937427521, 0.3505670726299286, -0.28197452425956726, -0.3379901051521301, 0.4196764826774597, 0.4217466115951538, -0.7089868187904358, 0.47734829783439636, -0.2330974042415619, 0.526068389415741, 0.04208651930093765, -0.22471415996551514, -0.24104084074497223, -0.4829103648662567, -0.2767214775085449, 0.0026954642962664366, 0.09021399915218353, 0.12820202112197876, -0.12785492837429047, 0.20761388540267944, 0.16328252851963043, -0.28969651460647583, 0.614539623260498, 0.40115344524383545, 0.15088579058647156, 0.11656688898801804, 0.7351354360580444, -0.13188615441322327, 0.6179486513137817, 0.34362250566482544, 0.46249231696128845, 0.7161093950271606, 0.28320974111557007, 0.6642985343933105, 0.15733550488948822, -0.21663865447044373, -0.5177705883979797, -0.033639922738075256, 0.11631299555301666, -0.06546604633331299, -0.061160195618867874, 0.8599495887756348, -0.8598207831382751, 0.3122037351131439, 0.15266279876232147, -0.33620089292526245, -0.32599160075187683, 0.8576728701591492, -0.04979158937931061, 0.1500055491924286, -0.08390985429286957, 0.6883863806724548, -0.36815983057022095, 0.19856640696525574, 0.4862503111362457, -0.867942214012146, 0.6008630394935608, -0.26712566614151, -0.013366245664656162, 0.14022237062454224, 0.9737392067909241, -0.6271984577178955, -0.29449039697647095, 0.1679771989583969, 0.35962703824043274, -0.2835395038127899, -0.08056648820638657, 0.24390825629234314, -0.36273255944252014, -0.1347915530204773, 0.4205563962459564, 0.2929754853248596, -0.13859888911247253, 0.2705586850643158, -0.35516270995140076, -0.22241084277629852, 0.24753673374652863, 0.13466611504554749, 0.07178886234760284, 0.015692034736275673, 0.21734607219696045, -0.5355502963066101, -0.30584463477134705, 0.3264918327331543, -0.41812559962272644, 0.33470600843429565, 0.18256868422031403, -0.12902416288852692, 0.24979877471923828, 0.5983677506446838, 0.07905290275812149, 0.011324461549520493, -0.8208647966384888, 0.34990566968917847, 0.34613847732543945, -0.8359574675559998, -0.0773739218711853, 0.07728731632232666, -0.30959010124206543, -0.16891136765480042, -0.6270821690559387, 0.1005585715174675, 0.2517682611942291, -0.34157589077949524, -0.060282837599515915, 0.06608990579843521, -0.33680516481399536, 0.30144599080085754, -0.06290668994188309, -0.34889790415763855, 0.13879916071891785, -0.10190965235233307, 0.0831785574555397, 0.3314453661441803, -0.061817679554224014, -0.3380771279335022, 0.3219591975212097, 0.3784833252429962, 0.2812984585762024, -0.05739077180624008, -0.04667288064956665, -0.3234277367591858, -0.15237513184547424, 0.22847647964954376, 0.22620351612567902, 0.17258860170841217, -0.37629982829093933, 0.010673893615603447, 0.11546886712312698, 0.24533726274967194, -0.11198367923498154, 0.14896389842033386, -0.6301541328430176, 0.24345506727695465, 0.2749832570552826, -0.1310473531484604, 0.28747594356536865, 0.3138846755027771, 0.11571104824542999, -0.29592373967170715, 0.18750713765621185, -0.40018847584724426, -0.10791805386543274, -0.009173300117254257, -0.7645344734191895, 0.10613521188497543, 0.2880559265613556, -0.04221964254975319, -0.12013140320777893, 0.33601200580596924, 0.004739835392683744, -0.10628972202539444, 0.6289660334587097, 0.19947631657123566, 0.052162475883960724, 0.18425895273685455, -0.17373143136501312, -0.5917509198188782, 0.21844574809074402, 0.38567298650741577, -0.8108240962028503, 0.3922905921936035, 0.333964467048645, -0.1584935337305069, 0.026727544143795967, -0.04649892449378967, 0.21340999007225037, -0.4085780680179596, -0.6773518323898315, -0.2077520787715912, 0.3808136582374573, -0.021035829558968544, 0.2021195888519287, 0.17216433584690094, 0.16528983414173126, -0.3585573434829712, -0.03285052627325058, -0.17963944375514984, 0.40987008810043335, -0.15226177871227264, -0.7214667201042175, -0.4422672986984253, 0.12213841080665588, 0.24165672063827515, -0.11616267263889313, 0.1896398812532425, 0.3903326392173767, 0.9530256390571594, 0.1095753088593483, 0.21211612224578857, 0.010990860871970654, -0.361152708530426, 0.10824788361787796, -0.531916081905365, 0.18306000530719757, -0.08136863261461258, -0.13771337270736694, -0.21988780796527863, -0.00875901523977518, -0.05508451536297798, -0.5536420345306396, 0.36623698472976685, 0.18274591863155365, -0.17608389258384705, -0.2303512841463089, 0.7818843722343445, 0.5199481248855591, -0.0776488333940506, 0.14040222764015198, -0.36656108498573303, 0.20628510415554047, -0.21340280771255493, 0.41724759340286255, -0.16240501403808594, -0.874326229095459, 0.2734997272491455, -0.4174562990665436, 0.25503218173980713, -0.5023404955863953, 0.1952788382768631, -0.5256711840629578, 0.11857576668262482, -0.532193124294281, -0.2660984396934509, 0.017259901389479637, -0.6147449016571045, -0.6095399260520935, -0.08843083679676056, 0.18758611381053925, 0.03158552199602127, 0.4031499922275543, 0.14807568490505219, -0.25560733675956726, -0.8518210649490356, 0.6758671402931213, 0.44311705231666565, 0.02813098393380642, -0.5463258028030396, 0.04101362079381943, 0.4510034918785095, 0.410719096660614, -0.5413640141487122, 0.07564201205968857, -0.013765379786491394, -0.11994421482086182, 0.3040178120136261, 0.45314744114875793, -0.11959894746541977, 0.11216948926448822, -0.004775215405970812, -0.24954862892627716, 0.154697448015213, 0.21772025525569916, 0.059382807463407516, 0.3802826702594757, 0.30682462453842163, 0.05887583643198013, -0.255500465631485, 0.26492732763290405, 0.1867581605911255, 0.3379907011985779, -0.1915232241153717, 0.6512280702590942, 0.5639439225196838, 0.20829176902770996, -0.19820578396320343, 0.8114460110664368, 0.32815954089164734, 0.3247329890727997, 0.0464489571750164, -0.5622032880783081, -0.18205082416534424, 0.024972237646579742, 0.5952234864234924, 0.24223822355270386, -0.08100639283657074, -0.2980169653892517, 0.08817311376333237, 0.14097093045711517, -0.42905089259147644, 0.14923319220542908, -0.43483424186706543, 0.08739537000656128, 0.19435282051563263, -0.4142903685569763, -0.5227217674255371, -0.2812879681587219, -0.791954517364502, 0.31668561697006226, 0.39691951870918274, -0.43477344512939453, -0.258410781621933, 0.45154404640197754, -0.48021766543388367, 0.023764893412590027, 0.08124399185180664, 0.6288356781005859, -0.12317940592765808, -0.004937105346471071, 0.3806493580341339, 0.10450489819049835, 0.2590720057487488, -0.3203953504562378, -0.006023595109581947, -0.472994327545166, -0.06450915336608887, 0.1389421820640564, 0.3972673714160919, -0.4479708671569824, 0.10448450595140457, -0.3257327079772949, -0.19290389120578766, 0.3805435001850128, -0.3539375364780426, 0.35705307126045227, -0.3729875981807709, -0.8022648096084595, -0.2690989375114441, -0.3353191316127777, -0.4749425947666168, 0.20876848697662354, 0.35223254561424255, 0.1397334337234497, 0.018031561747193336, -0.5417071580886841, 0.21147936582565308, 0.12692542374134064, 0.03019542433321476, -0.1646450161933899, -0.3325604200363159, 0.19304914772510529, 0.35852158069610596, 0.26869043707847595, 0.15231171250343323, 0.381846159696579, -0.089044950902462, 0.24468515813350677, -0.6569079756736755, 0.4627172648906708, -0.33558914065361023, -0.03241768479347229, -0.5015754699707031, -0.3413033187389374, 0.8097848892211914, 0.5777910351753235, -0.3278649151325226, -0.00047440125490538776, 0.7255628108978271, -0.062355782836675644, 0.6306039690971375, -0.6002886891365051, -0.48494988679885864, -0.5027976036071777, -0.12803547084331512, -0.4741940200328827, 0.5107619762420654, -0.1885862648487091, -0.3174828588962555, 0.04930700734257698, 0.3540650010108948, -0.022502681240439415, 0.14999157190322876, 0.30493053793907166, -0.33910220861434937, 0.013453411869704723, -0.889331042766571, 0.312529057264328, -0.3695921003818512, -0.31165769696235657, -0.5060681104660034, -0.10710286349058151, 0.3402217924594879, 0.05744510889053345, 0.24955520033836365, -0.09641208499670029, 0.04648251459002495, -0.006303241476416588, -0.00010216858936473727, 0.15850868821144104, -0.34688079357147217, -0.8497438430786133, -0.005977680906653404, 0.32266244292259216, 0.33211809396743774, -0.5247694253921509, -0.2479017972946167, 0.2243935912847519, -0.31229788064956665, -0.3480786681175232, 0.18829579651355743, -0.3810661733150482, 0.20035482943058014, -0.1183905228972435 ]
Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop from the mammary stem cell. To explore early cellular changes that occur in BRCA1 mutation carriers, we have prospectively isolated distinct epithelial subpopulations from normal mammary tissue and preneoplastic specimens from individuals heterozygous for a BRCA1 mutation. We describe three epithelial subsets including basal stem/progenitor, luminal progenitor and mature luminal cells. Unexpectedly, we found that breast tissue from BRCA1 mutation carriers harbors an expanded luminal progenitor population that shows factor-independent growth in vitro. Moreover, gene expression profiling revealed that breast tissue heterozygous for a BRCA1 mutation and basal breast tumors were more similar to normal luminal progenitor cells than any other subset, including the stem cell–enriched population. The c-KIT tyrosine kinase receptor (encoded by KIT) emerged as a key marker of luminal progenitor cells and was more highly expressed in BRCA1-associated preneoplastic tissue and tumors. Our findings suggest that an aberrant luminal progenitor population is a target for transformation in BRCA1-associated basal tumors .
[ -0.001488520298153162, 0.01716984435915947, -0.0014869068982079625, 0.017374545335769653, 0.03831883519887924, -0.024696387350559235, 0.013151941820979118, 0.021506985649466515, -0.016648130491375923, 0.012322059832513332, -0.017164196819067, 0.011217542923986912, 0.00001444108784198761, 0.009270476177334785, -0.049289535731077194, -0.009315823204815388, -0.02428700216114521, 0.00015756406355649233, 0.01659310609102249, 0.027603883296251297, 0.014184843748807907, -0.0014369357377290726, 0.010805230587720871, -0.024565231055021286, 0.03625573217868805, 0.03388398140668869, -0.006524788215756416, 0.01613263413310051, -0.02814292348921299, -0.0037909976672381163, 0.0032967347651720047, -0.021816782653331757, 0.017412032932043076, -0.017332768067717552, -0.00491954293102026, -0.024382099509239197, -0.0034064301289618015, 0.018387146294116974, 0.04918763414025307, -0.005369667895138264, 0.008590939454734325, -0.015952400863170624, -0.001621739473193884, -0.018528051674365997, -0.008685383945703506, -0.010964524000883102, -0.007326471619307995, 0.03250749781727791, 0.018198871985077858, 0.001268389169126749, -0.005384075455367565, -0.01683141104876995, -0.015399856492877007, -0.0050737811252474785, -0.007154781371355057, 0.005834878887981176, 0.021307777613401413, 0.004662632010877132, 0.03207911550998688, -0.01386265829205513, 0.025405216962099075, 0.004234780557453632, 0.023645387962460518, -0.006278353277593851, 0.004957864060997963, -0.06671508401632309, 0.03411377966403961, -0.009854456409811974, -0.02988111972808838, -0.007577699609100819, 0.0015185489319264889, 0.00928336102515459, -0.014760532416403294, -0.03399421647191048, -0.03341923654079437, -0.0024129170924425125, -0.022623788565397263, -0.004093075171113014, 0.013184738345444202, 0.04052766039967537, 0.014547264203429222, 0.004599015694111586, 0.0032769187819212675, 0.015490695834159851, -0.012126857414841652, 0.013588867150247097, -0.0380651131272316, 0.022296439856290817, 0.027088642120361328, -0.04917129874229431, -0.007486469112336636, 0.021527495235204697, -0.02872483618557453, -0.0106887798756361, -0.02752050943672657, -0.006118882913142443, -0.028127238154411316, -0.023484691977500916, -0.005900699645280838, 0.027744276449084282, -0.026370089501142502, -0.00020943116396665573, 0.014602476730942726, -0.0195477195084095, -0.01036093756556511, 0.010893582366406918, 0.015302585437893867, 0.007903337478637695, 0.03652433305978775, 0.010767271742224693, -0.02272874116897583, 0.006073375698179007, 0.002768031321465969, -0.005582685582339764, -0.02105684019625187, -0.029650378972291946, 0.0003557081217877567, 0.0012090248055756092, 0.008976642973721027, -0.014926979318261147, -0.013847102411091328, 0.00040125311352312565, -0.009857332333922386, 0.02050641179084778, 0.006437661591917276, -0.010876020416617393, -0.005635855719447136, 0.008650890551507473, 0.011182538233697414, 0.01183273270726204, -0.007335283327847719, 0.0017851225566118956, -0.04031083360314369, -0.013463437557220459, -0.013386659324169159, -0.00159008102491498, -0.011946127749979496, -0.0009461753070354462, -0.003910762257874012, -0.0141666941344738, 0.010915935039520264, 0.014409773051738739, 0.006991888862103224, 0.007609727792441845, -0.01737346313893795, -0.0004987353459000587, 0.012452984228730202, 0.007135835476219654, 0.013810024596750736, -0.017964530736207962, 0.012684510089457035, 0.0008424664847552776, -0.0283687561750412, -0.011121075600385666, 0.03543936833739281, 0.010763296857476234, -0.014876789413392544, -0.02537122182548046, 0.004464173223823309, 0.02255777269601822, -0.021561702713370323, -0.02342791110277176, 0.013871381059288979, 0.011025786399841309, 0.028868425637483597, -0.007221521809697151, 0.009347428567707539, -0.006597035564482212, 0.014811672270298004, 0.004259245470166206, 0.0026382883079349995, -0.019785219803452492, -0.018955308943986893, 0.013256152160465717, 0.0031001712195575237, 0.0003826180472970009, 0.03377167135477066, 0.00849287398159504, -0.03164679557085037, 0.06642148643732071, -0.005073757842183113, 0.01136956736445427, 0.0075708008371293545, -0.0016873875865712762, -0.0039749229326844215, 0.01152841467410326, -0.0011310320114716887, -0.004864446818828583, -0.040732722729444504, -0.0077970921993255615, 0.027311496436595917, 0.015518883243203163, -0.027478128671646118, 0.015456647612154484, -0.0393422394990921, 0.0032176775857806206, 0.008274009451270103, 0.018084611743688583, -0.003627154743298888, 0.024699147790670395, -0.028495168313384056, 0.00040040817111730576, 0.033516619354486465, -0.02026381716132164, 0.006811084691435099, 0.017373163253068924, 0.02258715033531189, -0.02500072866678238, -0.01658076047897339, -0.003155624959617853, 0.0052515617571771145, -0.01877114363014698, -0.002059702295809984, -0.0022109332494437695, 0.009468387812376022, 0.02805061638355255, 0.0005350382998585701, 0.020734786987304688, -0.017917541787028313, -0.016586273908615112, -0.003320306073874235, 0.020012110471725464, 0.0031974446028470993, -0.004600450396537781, -0.002220586873590946, -0.018516311421990395, -0.0026203005108982325, 0.010310310870409012, 0.017824294045567513, 0.012853222899138927, -0.02613738738000393, -0.06144590675830841, -0.01293867826461792, 0.0028633391484618187, -0.016033682972192764, -0.012600813992321491, 0.016343096271157265, 0.013679176568984985, 0.00854836218059063, -0.01090535894036293, -0.02107289619743824, 0.005319240503013134, 0.004046246409416199, -0.009288185276091099, 0.004696202464401722, -0.009135119616985321, 0.03847920522093773, 0.0046865809708833694, 0.022206060588359833, -0.025739312171936035, 0.010064763948321342, -0.0074615273624658585, 0.016865212470293045, 0.0328805074095726, 0.03421187400817871, -0.0021921030711382627, -0.027114050462841988, 0.016551833599805832, 0.027419298887252808, -0.006839520297944546, -0.0005079564871266484, 0.006760607939213514, 0.018394844606518745, -0.01037919707596302, -0.0042000883258879185, 0.009358040988445282, 0.0014501151163130999, 0.023578591644763947, 0.020621126517653465, -0.017842210829257965, 0.016766294836997986, -0.00784875638782978, 0.005777586251497269, -0.08125932514667511, -0.011966004967689514, 0.0059625678695738316, -0.023249320685863495, 0.010600384324789047, 0.01312545407563448, -0.014700676314532757, -0.005217268597334623, -0.006798448972404003, 0.012628965079784393, 0.0028988285921514034, -0.005325786769390106, -0.005855201277881861, -0.015270613133907318, 0.034019358456134796, -0.0030731246806681156, 0.014946102164685726, -0.03422155976295471, 0.00012147147208452225, -0.05201441049575806, 0.016224302351474762, 0.01917586848139763, 0.017154987901449203, 0.028555165976285934, -0.04226329177618027, 0.013183936476707458, -0.038484953343868256, -0.0070843324065208435, 0.007932012900710106, 0.0002868270385079086, 0.0018245091196149588, -0.0175975002348423, 0.0241556316614151, 0.012230591848492622, -0.014692576602101326, 0.02785220742225647, -0.007485666312277317, -0.031630534678697586, -0.024168595671653748, 0.022657113149762154, -0.02650419995188713, 0.015739405527710915, 0.013606365770101547, 0.004137677140533924, 0.0015180306509137154, 0.015883730724453926, 0.012584448792040348, 0.009691759943962097, 0.025207797065377235, -0.0055298516526818275, 0.016819581389427185, -0.000631965696811676, 0.009071341715753078, 0.01684512570500374, -0.012945341877639294, -0.012271460145711899, -0.019956402480602264, -0.02168462425470352, -0.009076336398720741, -0.0057778190821409225, 0.01172643806785345, 0.006341953761875629, 0.044373635202646255, 0.01633794605731964, 0.016028929501771927, 0.03670429810881615, 0.006693538278341293, -0.03336653858423233, -0.007511405274271965, 0.014988905750215054, -0.012456708587706089, -0.008507189340889454, 0.012836658395826817, -0.006271985359489918, -0.01146441139280796, -0.006083953194320202, -0.011656216345727444, -0.013653818517923355, 0.005719112232327461, -0.004619405139237642, 0.0003858634736388922, -0.018982555717229843, -0.02215595543384552, 0.007307369261980057, -0.028045807033777237, -0.016511648893356323, 0.005921458825469017, 0.033495597541332245, 0.012210290879011154, -0.0216104406863451, 0.022761782631278038, 0.013494687154889107, 0.014509782195091248, 0.011684472672641277, 0.017252204939723015, -0.027387220412492752, -0.02591632306575775, 0.0200587697327137, 0.01911885477602482, 0.009636718779802322, -0.02885473147034645, 0.002037174068391323, 0.0009815217927098274, -0.006323892157524824, -0.039369627833366394, 0.015155762434005737, 0.014276258647441864, 0.01628146879374981, 0.001399568747729063, -0.00010522769298404455, -0.0021688956767320633, -0.0007529137656092644, -0.0070489742793142796, 0.011913745664060116, 0.015577221289277077, 0.021031096577644348, -0.008983938954770565, -0.035577334463596344, 0.07102932780981064, -0.010464338585734367, -0.002846087096258998, -0.028050025925040245, 0.030576512217521667, -0.015141487121582031, -0.01350370142608881, -0.014098385348916054, -0.06071992591023445, 0.01356288231909275, 0.015391703695058823, 0.03805415332317352, 0.004300638567656279, 0.01867549680173397, -0.03383325785398483, 0.020279020071029663, -0.002647919114679098, -0.003058248432353139, 0.035387806594371796, 0.018891222774982452, -0.019468000158667564, -0.027358945459127426, -0.006876970175653696, 0.002877301536500454, -0.01709192804992199, 0.009539654478430748, -0.014286886900663376, -0.013287884183228016, -0.010988423600792885, 0.006166554056107998, 0.010865684598684311, -0.012750739231705666, -0.00870554894208908, 0.0075096008367836475, 0.0133720263838768, -0.0016935879830271006, 0.02933102287352085, -0.0027005434967577457, -0.011380720883607864, 0.005561716388911009, 0.0000603950466029346, -0.013642570935189724, 0.0016972727607935667, 0.006998187862336636, -0.009647626429796219, -0.01783093810081482, 0.03936486691236496, -0.005501494277268648, 0.008977966383099556, -0.011115241795778275, -0.008605601266026497, 0.007542915642261505, 0.015615246258676052, 0.010181577876210213, -0.011972476728260517, 0.008450079709291458, 0.02007458359003067, -0.006637554615736008, 0.004634298849850893, -0.011216454207897186, -0.028515268117189407, -0.008317286148667336, -0.002607417991384864, -0.0186848696321249, 0.010203009471297264, -0.00944005511701107, -0.018193788826465607, -0.007369149476289749, 0.02239793911576271, -0.01011888962239027, 0.038976266980171204, 0.006265450268983841, -0.025619003921747208, 0.0007352679967880249, -0.01243070513010025, 0.020620113238692284, 0.0037820525467395782, 0.007835064083337784, -0.015078715980052948, 0.01752956211566925, 0.011518040671944618, 0.004324738867580891, 0.011012889444828033, 0.0036587314680218697, 0.0016845129430294037, -0.016384141519665718, -0.002750169951468706, -0.074857696890831, 0.002426648512482643, -0.005790978670120239, -0.004850994795560837, 0.015364974737167358, 0.002056743483990431, -0.010789657942950726, -0.026280732825398445, -0.006403852254152298, -0.00503490911796689, -0.035699788480997086, -0.02101372741162777, 0.0009191585704684258, 0.0015767780132591724, 0.015884896740317345, 0.037807904183864594, 0.0057325102388858795, -0.019224168732762337, -0.03774461895227432, 0.014202600345015526, 0.01612907648086548, 0.011499395594000816, -0.007545681670308113, 0.004808191210031509, -0.005230417475104332, -0.07990987598896027, 0.023306192830204964, -0.014215310104191303, 0.013706918805837631, -0.000951742404140532, -0.02410956844687462, 0.005604322534054518, -0.014179877936840057, -0.025103792548179626, -0.019856587052345276, -0.003556549549102783, 0.00190855679102242, -0.004282228648662567, -0.012910997495055199, 0.04061069339513779, -0.010819240473210812, 0.01341450959444046, -0.005664843134582043, -0.03652593493461609, 0.02540360763669014, 0.003892607521265745, -0.00011902255937457085, -0.011366371065378189, -0.00592887494713068, -0.008483171463012695, -0.014356143772602081, -0.013821825385093689, 0.018616948276758194, 0.01582261547446251, 0.004795916378498077, -0.018470022827386856, 0.002799627836793661, -0.031040329486131668, 0.004733780398964882, 0.004280423279851675, -0.023035190999507904, -0.012541035190224648, -0.004687543027102947, 0.003945971839129925, 0.019354552030563354, -0.004439289215952158, 0.03331521153450012, -0.01809466816484928, 0.009675383567810059, 0.009432269260287285, 0.015060821548104286, 0.011635267175734043, -0.003968916367739439, -0.0007935899775475264, 0.023733139038085938, 0.01314033567905426, 0.013303985819220543, 0.006478229537606239, 0.005187738686800003, 0.007860878482460976, 0.0029076167847961187, 0.01003279723227024, -0.00047898758202791214, 0.029004471376538277, 0.017932873219251633, 0.0008476039511151612, 0.008885245770215988, -0.0007041329517960548, 0.07127290964126587, -0.009705279022455215, 0.021191786974668503, 0.00900808535516262, 0.0009320011595264077, 0.013487681746482849, -0.04676293581724167, 0.0169517919421196, -0.02701757475733757, -0.0049535539001226425, 0.0038245394825935364, -0.008093660697340965, 0.022921135649085045, 0.01502949371933937, 0.011551788076758385, -0.023249542340636253, -0.011454646475613117, -0.03082457184791565, -0.013530438765883446, -0.0024475515820086002, 0.007477613631635904, 0.020484797656536102, -0.030890222638845444, 0.003556603565812111, 0.005494344048202038, -0.019841544330120087, -0.04129602015018463, 0.011154698207974434, -0.014960082247853279, 0.0024020858108997345, -0.006579484790563583, 0.007674265652894974, 0.006355386693030596, 0.003895406611263752, 0.018733251839876175, 0.03301551938056946, -0.0065871430560946465, 0.008571328595280647, 0.009190108627080917, -0.016564715653657913, -0.026261799037456512, 0.011132091283798218, -0.013571027666330338, -0.013995899818837643, 0.01546064019203186, -0.027656685560941696, -0.0035437890328466892, 0.01647702418267727, -0.0021514762192964554, 0.02771734446287155, 0.02173597924411297, 0.009150056168437004, 0.0062690251506865025, -0.01126590371131897, 0.01847982406616211, -0.013451470993459225, -0.007096211891621351, 0.026074420660734177, -0.028523579239845276, -0.0032073822803795338, 0.02797568030655384, -0.008398567326366901, -0.0057029505260288715, -0.021701287478208542, -0.0015416598180308938, -0.0435091108083725, 0.012940638698637486, -0.027312882244586945, 0.008981658145785332, 0.015399113297462463, -0.00022395234555006027, 0.01497049629688263, 0.006552179343998432, 0.01931709237396717, 0.007888096384704113, 0.002273998223245144, 0.016225341707468033, 0.028603069484233856, 0.0070204115472733974, 0.005770592018961906, -0.005715406499803066, 0.0041578542441129684, 0.012762261554598808, -0.007958682253956795, -0.046622034162282944, 0.01889193058013916, -0.003930976148694754, -0.026088913902640343, 0.00118487817235291, 0.011604182422161102, 0.020578715950250626, 0.011922990903258324, 0.003811364294961095, 0.019875239580869675, 0.01178746111690998, 0.035976674407720566, 0.02456631325185299, 0.01240619271993637, 0.004570514429360628, 0.003618147224187851, -0.020810740068554878, 0.027079496532678604, -0.03135708346962929, -0.03835136443376541, -0.021129708737134933, -0.019004609435796738, 0.0009812498465180397, -0.021647732704877853, 0.008425211533904076, 0.024389322847127914, -0.004923652391880751, -0.005938264541327953, 0.006485053803771734, -0.010198831558227539, -0.00473840581253171, 0.007392610888928175, -0.004222054034471512, -0.001207080902531743, 0.013904795050621033, -0.019092055037617683, -0.037076953798532486, -0.0035645426250994205, -0.006129319313913584, 0.026638468727469444, -0.03524239361286163, 0.008980909362435341, -0.010625752620398998, 0.02827206440269947, -0.016667192801833153, -0.013922756537795067, 0.021110989153385162, -0.024865854531526566, -0.005334368906915188, 0.03503427654504776, 0.007698202505707741, 0.006632333155721426, 0.00730906194075942, -0.009936349466443062, 0.00010769348591566086, 0.03710046038031578, 0.028063662350177765, -0.008717935532331467, -0.0008164314785972238, 0.03751811385154724, 0.010351469740271568, -0.029344359412789345, 0.018390415236353874, 0.0022088470868766308, 0.009470981545746326, -0.02053053304553032, 0.006699087098240852, 0.0018431497737765312, -0.0006211477448232472, -0.00863029807806015, 0.004150261636823416, 0.0005447252187877893, 0.011731646955013275, -0.0050331358797848225, 0.0027139270678162575, -0.020719731226563454, -0.02036888524889946, 0.008421449922025204, 0.018218999728560448, -0.026224486529827118, 0.020607393234968185, -0.014451615512371063, 0.022242825478315353, -0.017535151913762093, -0.010170838795602322, -0.00041957106441259384, 0.03438269719481468, -0.005201143212616444, -0.010901052504777908, 0.004050810821354389, -0.03301168233156204, -0.010882304981350899, -0.017174147069454193, -0.019799048081040382, -0.007312354631721973, -0.0050234077498316765, -0.007318506948649883, 0.0009938525035977364, 0.001431644894182682, -0.01163045410066843, -0.01882913149893284, -0.024097684770822525, 0.001683050999417901, -0.0009510940872132778, 0.006126105319708586, -0.003843718208372593, -0.0038759270682930946, -0.01210720557719469, 0.003888644278049469, -0.00643963273614645, -0.004541059024631977, -0.021602801978588104, 0.024004273116588593, 0.017444880679249763, -0.017774002626538277, -0.002038137521594763, 0.02862231247127056, -0.007192098535597324 ]
[ 0.16122885048389435, -0.1757666915655136, 0.44237688183784485, 0.046481143683195114, 0.24107499420642853, 0.3258475959300995, -0.24197128415107727, 0.25189781188964844, -0.1701013743877411, -0.44148340821266174, 0.053609732538461685, -0.10935879498720169, -0.2119523286819458, 0.3134993612766266, -0.4527392089366913, 0.48152223229408264, 0.4992024600505829, 0.36739444732666016, -0.026664139702916145, -0.4062637388706207, -0.13868235051631927, -0.4287026524543762, 0.6568568348884583, -0.2840667963027954, 0.3165073096752167, -0.38009077310562134, 0.3463900089263916, 0.22324874997138977, 0.459836483001709, 0.14390145242214203, -0.2264283299446106, 0.27955031394958496, 0.2946503460407257, 0.16985000669956207, -0.21124978363513947, -0.05856332927942276, -0.202137753367424, 0.07786215096712112, -0.2515031695365906, -0.4585443437099457, -0.4549179673194885, -0.4089316129684448, 0.0903625562787056, 0.7229288220405579, -1.0350830554962158, 0.15288838744163513, -0.938058078289032, 1.1570847034454346, -0.30272072553634644, 0.2935783565044403, 0.04798606410622597, 0.13093125820159912, 0.4071618318557739, 0.11108220368623734, 0.6858687400817871, 0.1629795879125595, -0.6667784452438354, 0.2316129505634308, 0.40578997135162354, -0.8574878573417664, 0.08005918562412262, 0.39674749970436096, -0.11778098344802856, -0.309767484664917, 0.19769923388957977, 0.8813365697860718, -0.004375639371573925, -0.6178134679794312, -0.7179960012435913, -0.14506258070468903, -0.1440998613834381, -0.6694691777229309, 0.23248907923698425, 1.031540870666504, -0.22880037128925323, 0.229172021150589, -0.3114118278026581, -0.2238885760307312, 0.38585296273231506, 0.21083985269069672, -0.3052077293395996, 0.0413421206176281, 0.7537397742271423, 0.498706191778183, 0.1986147165298462, 0.29378899931907654, -0.11740904301404953, 0.20905154943466187, -0.4717302918434143, 0.07618944346904755, -0.5697600245475769, -0.19742770493030548, 0.8708541393280029, 0.5684022903442383, 0.2105754017829895, 0.12410467118024826, 0.17705772817134857, -0.1876821368932724, 0.1533862054347992, -0.0012099688174203038, -0.6878966093063354, 0.09704510122537613, 0.18103298544883728, -0.5361523628234863, -0.830214262008667, -0.33351483941078186, 0.3717471659183502, 0.10371038317680359, -0.6981839537620544, -0.33127787709236145, -1.1408319473266602, 0.1133570522069931, -0.2798732817173004, 0.2604796588420868, 0.11906373500823975, 0.7733475565910339, -0.4323534667491913, -0.8611240983009338, -0.4703044295310974, -0.48035919666290283, -0.17980951070785522, 0.8954683542251587, -0.293757826089859, 0.21090877056121826, 0.09351713210344315, 0.16149255633354187, 0.37612372636795044, 0.3607390522956848, 0.12820087373256683, 0.6173054575920105, -0.047743622213602066, 0.7170705199241638, -0.09088738262653351, 0.3458528518676758, 0.2077121138572693, -0.6915683746337891, 0.48999831080436707, 0.01856250874698162, 0.8134610652923584, 0.5453932285308838, -0.8331639766693115, -0.16587969660758972, -0.07656356692314148, -0.4872577488422394, 0.13643097877502441, -0.7529520988464355, 0.24171823263168335, -0.011147910729050636, -0.32426556944847107, -0.6262000203132629, -0.08767285943031311, -0.207691490650177, -0.12473314255475998, -0.6340912580490112, 0.06783898174762726, 0.3639915883541107, 0.2700616717338562, -0.10595183819532394, 0.12903641164302826, 0.17711104452610016, -0.039193954318761826, 0.31544849276542664, -0.30013227462768555, -0.05185922235250473, 0.5644565224647522, -0.30017685890197754, 0.3987467586994171, 0.31795668601989746, -0.2577189803123474, 0.836941123008728, -0.38490381836891174, -0.3200080394744873, 0.13004541397094727, -0.044118840247392654, -0.2050400823354721, -0.20254702866077423, 0.1885949671268463, -0.40711814165115356, 0.2007393091917038, -0.26552537083625793, -0.6174502968788147, 0.3531869649887085, 0.5699877738952637, 0.06739214062690735, -0.29516634345054626, -0.335852712392807, 0.2560538947582245, 0.3126365542411804, 0.1567889004945755, -0.0615449883043766, -0.028597524389624596, -0.4870094656944275, 1.1360795497894287, -0.10214759409427643, 1.0200021266937256, -0.06867046654224396, -0.12503640353679657, 0.9287010431289673, -0.2513114809989929, 0.2684122622013092, 0.15287315845489502, -0.20827141404151917, 0.5540043711662292, -0.1789657026529312, -0.526202917098999, -0.09556309878826141, -0.2136334925889969, -0.584718644618988, 0.4657999873161316, -0.2659180760383606, 0.47034865617752075, -0.3166734278202057, 0.02540832757949829, 0.12301269918680191, 0.2350672334432602, -0.26573216915130615, -0.29089611768722534, -0.16940748691558838, 0.07347738742828369, -0.7379513382911682, 0.6188839673995972, -0.6912508010864258, 0.8412525653839111, 0.2958793044090271, 0.23525966703891754, 0.5644423365592957, 0.5174877047538757, -0.08792626112699509, 0.975416362285614, 0.2412719428539276, 0.17965976893901825, -0.2650313079357147, 0.15481962263584137, -0.7414986491203308, 0.09341654926538467, 0.15823335945606232, 0.2387428730726242, -0.31410789489746094, 0.15479953587055206, 0.18109633028507233, -0.06364358961582184, 0.4572010338306427, -1.017465591430664, -0.3539128005504608, -0.041950423270463943, -0.4880789518356323, -0.5769062042236328, 0.1493922621011734, -0.6450664401054382, -0.0755365639925003, -0.6218857765197754, 0.2520214915275574, -0.5187313556671143, -0.443571537733078, -0.41729095578193665, 0.5346848964691162, -0.2286645621061325, -0.07235006988048553, 0.5979898571968079, -0.4107401371002197, -0.23790207505226135, 0.10840842127799988, -0.2581128776073456, -0.017221616581082344, 0.00414374191313982, -0.6372087597846985, -0.45504647493362427, -0.6653959155082703, 1.3973256349563599, 0.804338276386261, 0.4812256991863251, 0.16313354671001434, -0.5855017900466919, -0.14642958343029022, -0.3163812756538391, -1.0294914245605469, -0.2522972524166107, 0.10024581104516983, -0.3575034737586975, -0.7306632995605469, 0.1541251391172409, 0.6277803778648376, 1.4384630918502808, 0.17291618883609772, -0.4529263377189636, 0.12009523063898087, 0.41677960753440857, -0.3324969708919525, -0.07376240938901901, -0.0973854586482048, -0.24963782727718353, 0.5464504957199097, -0.6703406572341919, -0.20381289720535278, 0.43307724595069885, 0.0007166989962570369, 0.31237614154815674, -0.306983083486557, 0.4641685485839844, 0.04904302582144737, -0.6734358668327332, -0.15223373472690582, 0.15942254662513733, -0.19361338019371033, 0.05790773406624794, 0.24787965416908264, 0.0785125344991684, -0.09912094473838806, -5.597507476806641, 0.19100064039230347, 0.0706695020198822, -0.5339893698692322, -0.19580544531345367, -0.06552667170763016, 0.47578370571136475, 0.18433314561843872, 0.11037620902061462, -0.10961074382066727, -0.011369842104613781, 0.533009946346283, -0.4892524182796478, -0.22127856314182281, -0.24881495535373688, -0.12852545082569122, -0.43658486008644104, -0.2658451497554779, 0.6303442716598511, -0.24835549294948578, 0.049471937119960785, -0.5095371007919312, 0.19603675603866577, 0.7731670141220093, 0.31085827946662903, 0.753822386264801, -0.5670747756958008, -0.106209397315979, -0.3136967122554779, -1.0447874069213867, -0.06990449875593185, -0.5275207757949829, 0.1365518718957901, -0.10822246968746185, 0.1992676705121994, 0.48498186469078064, 0.2681698799133301, 0.2239101678133011, 0.16357479989528656, -0.3628920018672943, 0.5224248170852661, -0.0775284692645073, -0.07353954762220383, -0.18302173912525177, 0.39049267768859863, -0.05067956820130348, -0.2977800667285919, 0.12436243146657944, -0.1770670861005783, 0.8107153177261353, -0.015578151680529118, 0.06263863295316696, 0.30004650354385376, 0.3919717073440552, 0.3050646185874939, 0.7462723851203918, -0.1979770064353943, 0.005285939201712608, -0.4883027970790863, -0.2687360942363739, 0.0021316579077392817, 0.16346463561058044, -0.23295998573303223, -1.0492357015609741, 0.33993014693260193, 0.06513679027557373, -0.7171664237976074, 0.2511802017688751, 0.3544136583805084, -0.13525961339473724, 0.294720321893692, -0.12413222342729568, 0.4159145653247833, -0.6689652800559998, 0.4366682469844818, -0.6962013840675354, -0.09798158705234528, 0.05277729034423828, -0.22125022113323212, -0.04186275973916054, 0.06070435047149658, -0.11521103978157043, -0.014126773923635483, 0.03731972351670265, -0.003222404746338725, -0.33130913972854614, -0.6136842370033264, 0.09221106767654419, -0.2805629372596741, 0.5661283731460571, 0.6185665130615234, 0.017307164147496223, 0.14610989391803741, 0.1678859144449234, 0.5051962733268738, 0.2461831420660019, 0.4679957926273346, 0.4824584722518921, 0.5560694336891174, -0.3153442442417145, 0.7728807926177979, -0.04827208071947098, -0.6087431907653809, -0.45868462324142456, -0.5766881704330444, 0.03668977692723274, -0.8294253945350647, 0.040042679756879807, 0.7196277976036072, -0.6180332899093628, 0.6908591389656067, -0.2915300726890564, -0.07210955023765564, -0.4643773138523102, 0.7319027781486511, 0.07202054560184479, -0.5687603950500488, 0.3418784439563751, 1.0230885744094849, -0.4379228353500366, 0.14829906821250916, 0.024497607722878456, -0.42992138862609863, 0.332485556602478, 0.4747192859649658, -0.24886873364448547, 0.48321273922920227, 0.8901099562644958, -0.9824564456939697, -0.07810582965612411, 0.13775832951068878, 0.13727472722530365, -0.5378882884979248, -0.48341360688209534, -0.09489670395851135, 0.5159644484519958, -0.5306864976882935, 0.0754300057888031, 0.5573615431785583, 0.326572448015213, 0.3661790192127228, -0.29454487562179565, -0.07742307335138321, 0.3847634494304657, 0.19749148190021515, -0.027227070182561874, 0.08507845550775528, 0.11593668162822723, -0.18736441433429718, -0.0724068135023117, 0.5076223611831665, 0.2756790816783905, 0.6226130723953247, -0.6823764443397522, -0.7230160236358643, 0.29457202553749084, 0.6824694275856018, 0.31242623925209045, -0.47913259267807007, -0.15226034820079803, 0.13657251000404358, -0.06706690788269043, -0.13241888582706451, 0.08086345344781876, -0.2877119779586792, -0.4405272901058197, -0.25010812282562256, -0.7198930978775024, -0.09231791645288467, 0.18306761980056763, 0.009287207387387753, -0.22427289187908173, 0.33147725462913513, -0.12788331508636475, 0.16895365715026855, -0.582152247428894, -0.25800105929374695, 0.255084753036499, -0.005980210844427347, 0.45695340633392334, -0.15080353617668152, -0.302390992641449, -0.043228086084127426, 0.4416220784187317, 0.9878346920013428, 0.5129330158233643, -0.44062453508377075, 0.08360605686903, -0.4646852910518646, -0.2190810889005661, -0.19989733397960663, -0.185175359249115, 0.5259672999382019, 0.07238158583641052, 0.16480647027492523, 0.2735157907009125, -0.08487488329410553, 0.27173420786857605, -0.10658740252256393, -0.9991499781608582, 0.1810741126537323, -0.03217986971139908, -0.5997611284255981, 0.6541888117790222, 0.6768641471862793, -0.40376609563827515, 0.1069180816411972, -0.4582020044326782, -0.6304212212562561, -0.05041424185037613, -0.5378001928329468, -0.6392071843147278, 0.5228189826011658, 0.28086405992507935, -0.5788798332214355, -0.13825485110282898, -0.22247456014156342, -0.2526511251926422, -0.3667025566101074, 0.26190048456192017, 0.4132678508758545, -0.3944789469242096, 0.11622990667819977, -0.10246944427490234, -0.583119809627533, 0.4169537127017975, 0.3178902864456177, -0.7310146689414978, 0.16431136429309845, -0.18254151940345764, 0.42991942167282104, 0.22708579897880554, -0.1282103806734085, -0.4834360182285309, -0.3469853401184082, -0.47901442646980286, 0.23391032218933105, -0.026052255183458328, 0.0797436535358429, 0.6378427147865295, 0.87031090259552, 0.49750158190727234, -0.47809329628944397, -0.06941781938076019, 0.04881438985466957, 0.2835294008255005, 0.23242561519145966, -0.8285702466964722, -0.4863753616809845, 0.2519800364971161, 0.5092159509658813, -0.7267897725105286, 0.09893544018268585, 0.28543639183044434, 0.9772557020187378, -0.05387520045042038, 0.052310097962617874, -0.5960975885391235, -0.28371506929397583, 0.23655816912651062, -0.24145735800266266, -0.45269444584846497, -0.09350351244211197, 0.1267513483762741, 0.25723400712013245, -0.16272222995758057, -0.3409256935119629, -0.143496572971344, 0.4823315143585205, -0.3037808835506439, 0.20944415032863617, 0.36918193101882935, 0.7014424204826355, -0.012727943249046803, 0.11581161618232727, 0.10254693776369095, 0.013215004466474056, 0.15041698515415192, -0.06275589019060135, 0.10522428900003433, -0.43241065740585327, -0.2959965169429779, 0.7648109793663025, -0.23304998874664307, 0.04844065010547638, -0.8259406685829163, 0.2126501351594925, -0.5695001482963562, -0.17850707471370697, -0.1741960346698761, -0.10552289336919785, -0.29625168442726135, -0.024847837164998055, -0.5431903004646301, 0.2911240756511688, 0.06555166840553284, 0.2262098789215088, 0.14513443410396576, 0.043928321450948715, 0.15868325531482697, -0.5581214427947998, 0.6335880160331726, 0.03360912576317787, -0.0781003013253212, 0.06729411333799362, 0.07999475300312042, 0.4410974383354187, -0.2910149097442627, -0.3285433351993561, -0.5652501583099365, 0.08706306666135788, -0.008084815926849842, 0.46290504932403564, 0.1705179512500763, -0.5061845779418945, 0.2267148494720459, -0.4358421266078949, -0.28206396102905273, -0.10708238184452057, 0.3851049542427063, 0.2627813220024109, 1.2191630601882935, 0.19938191771507263, 0.030159780755639076, 0.38624095916748047, 0.23354125022888184, 0.023091191425919533, 0.10162675380706787, 0.20018884539604187, 0.3261173963546753, 0.5200260281562805, 0.8098149299621582, 0.1403464376926422, 0.3926290273666382, 0.38072314858436584, 0.036325227469205856, -0.34578317403793335, -0.23090937733650208, -0.4662459194660187, 0.5109353065490723, 0.3592996895313263, -0.008612021803855896, -0.5239670872688293, -0.44373756647109985, 0.06857975572347641, 0.1937570571899414, -0.21757102012634277, 0.2619406580924988, 0.4603998064994812, 0.5272494554519653, 0.052612513303756714, -0.8961579203605652, -0.3733370006084442, 0.4033176600933075, -0.35287293791770935, 0.10730654001235962, -0.11892069876194, -0.33452489972114563, -0.556855320930481, 0.16346335411071777, -0.9473487138748169, 0.2447880506515503, -0.12353526800870895, 0.8310074210166931, -0.29274019598960876, 0.3175133764743805, -0.04741324484348297, -0.16036124527454376, 0.24975168704986572, -0.3077485263347626, 0.5948992967605591, 0.250937819480896, -0.09705669432878494, 0.055455368012189865, -0.029370252043008804, -0.19571331143379211, 0.15340015292167664, 0.14146821200847626, -0.04297763854265213, -0.00024616459268145263, -0.5877059698104858, -0.41827812790870667, 0.11179308593273163, -0.39863452315330505, -0.10852203518152237, -0.4573170244693756, -0.16225619614124298, -0.2206207513809204, 0.07083094120025635, 0.424082487821579, 0.33879053592681885, -0.81277996301651, 0.982690155506134, 0.11214814335107803, -0.20168983936309814, 0.2714133858680725, -0.03901662677526474, 0.15993763506412506, 0.3456493020057678, 0.16262409090995789, -0.3268445134162903, 0.2388390600681305, 0.07923159748315811, 0.3812776803970337, -0.33688756823539734, 0.4207136034965515, -0.6554641127586365, -0.9794560670852661, -0.6025988459587097, -0.2650524079799652, 1.0334160327911377, 0.1339472234249115, -0.29715868830680847, 0.7880640625953674, 0.29024600982666016, 0.7289628386497498, -0.0977347120642662, -0.36189913749694824, -0.2999955713748932, -0.2325003743171692, -0.03737085312604904, -0.4046991169452667, 0.18213707208633423, 0.2746221125125885, 0.3251766264438629, -0.12454958260059357, 0.24128755927085876, 0.4393576383590698, -0.5053631663322449, 0.4881753921508789, -0.4821353256702423, 0.11528448015451431, -0.41219842433929443, 0.30632397532463074, -0.5292572975158691, 0.13118858635425568, -0.0610525980591774, 0.026857934892177582, -0.1305084228515625, -0.21385614573955536, 0.10219354182481766, -0.2991555333137512, 0.1655728816986084, 0.06801480054855347, 0.10724571347236633, 0.024186043068766594, -0.04711821675300598, -0.5287525057792664, -1.1868066787719727, 0.2677031457424164, -0.2221413254737854, -0.4221575856208801, 0.31589528918266296, -0.018642665818333626, -0.2634894847869873, 0.089254230260849, -0.20243504643440247, -0.09319448471069336, -0.3067576587200165, 0.13733699917793274 ]
Neutrophil recruitment, lymphocyte recirculation and monocyte trafficking all require adhesion and transmigration through blood-vessel walls. The traditional three steps of rolling, activation and firm adhesion have recently been augmented and refined. Slow rolling, adhesion strengthening, intraluminal crawling and paracellular and transcellular migration are now recognized as separate, additional steps. In neutrophils, a second activation pathway has been discovered that does not require signalling through G-protein-coupled receptors and the signalling steps leading to integrin activation are beginning to emerge. This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade.
[ -0.02613651007413864, 0.01890324428677559, -0.004679180681705475, 0.0237850584089756, -0.0031467247754335403, -0.007651865016669035, 0.013987205922603607, -0.015562320128083229, -0.012589709833264351, -0.01643482595682144, -0.014553002081811428, 0.008803650736808777, -0.014435626566410065, 0.012157243676483631, -0.004154252354055643, 0.023505892604589462, -0.01456492766737938, 0.005496491212397814, 0.00951701495796442, 0.008479788899421692, -0.019422776997089386, -0.0013018087483942509, 0.011478755623102188, -0.06556510180234909, 0.011994032189249992, -0.010518715716898441, 0.00046872918028384447, -0.019276462495326996, 0.004236720502376556, 0.01259874738752842, 0.019002385437488556, 0.011913918890058994, 0.004980871453881264, 0.010885125026106834, 0.0015593620482832193, 0.03031749650835991, -0.008578689768910408, 0.04040023684501648, -0.02858409471809864, -0.0071905250661075115, -0.014271668158471584, -0.011072693392634392, 0.006258738227188587, 0.0020538768731057644, -0.006404074840247631, 0.001577042043209076, -0.004669364541769028, 0.02234318107366562, -0.029278066009283066, 0.006455376744270325, -0.019063401967287064, -0.026565663516521454, -0.005746281705796719, 0.0458788238465786, -0.007907572202384472, -0.015393881127238274, 0.020151523873209953, -0.007586535066366196, -0.018626023083925247, -0.030075684189796448, -0.007435480132699013, 0.0012337244115769863, 0.02851756289601326, 0.013093528337776661, -0.0013572927564382553, -0.06613712012767792, 0.006201683543622494, 0.014510630629956722, -0.020652949810028076, 0.022666646167635918, -0.0012881644070148468, 0.007762335240840912, -0.018885206431150436, -0.018866881728172302, -0.01369224488735199, -0.007652181200683117, 0.005091742612421513, 0.021959170699119568, 0.0021709562279284, 0.012961646541953087, 0.001977645792067051, -0.013823545537889004, -0.010144468396902084, 0.011389410123229027, -0.0000010454095900058746, 0.0013759206049144268, -0.00015008915215730667, 0.010421646758913994, 0.007016909308731556, -0.02492659166455269, -0.019515253603458405, -0.004989258013665676, -0.020354967564344406, 0.007810525596141815, -0.008768610656261444, 0.011866483837366104, 0.0014106429880484939, 0.014981954358518124, 0.03294706717133522, 0.008749202825129032, -0.019218403846025467, -0.003937405999749899, 0.02020907774567604, 0.001885115634649992, 0.037171319127082825, 0.011507067829370499, 0.006992443464696407, 0.02244683727622032, 0.0218688752502203, 0.009554658085107803, -0.02647515758872032, 0.01782367378473282, -0.02209630236029625, 0.019023865461349487, -0.0065066940151154995, -0.008073806762695312, -0.025261417031288147, 0.009085073135793209, 0.006060491781681776, 0.004977436736226082, 0.018952546641230583, -0.016550537198781967, 0.004607449285686016, 0.010511736385524273, 0.013523787260055542, 0.00950750894844532, 0.009038601070642471, 0.019093859940767288, 0.020134691148996353, 0.021376753225922585, -0.010534491389989853, 0.015637602657079697, 0.00013868906535208225, 0.01878858357667923, 0.003354773623868823, 0.0009739890228956938, -0.018828222528100014, 0.007629898376762867, -0.002580752596259117, 0.0005910522304475307, 0.024978749454021454, 0.010125041007995605, -0.001171721494756639, 0.010944796726107597, 0.008060210384428501, 0.003977208863943815, -0.024460606276988983, -0.0020897085778415203, -0.02458774484694004, -0.016856376081705093, 0.004697957541793585, 0.021657217293977737, -0.008067536167800426, -0.026895811781287193, -0.02680351585149765, 0.007518263068050146, -0.008495839312672615, -0.03425801917910576, -0.006866175681352615, 0.013956848531961441, 0.011523982509970665, -0.010939519852399826, 0.00311786076053977, 0.00972900353372097, 0.0033124079927802086, -0.002979456912726164, 0.0006517069414258003, -0.009488149546086788, 0.010838771238923073, 0.011964669451117516, -0.007868057116866112, 0.026766419410705566, -0.01627478189766407, 0.0031038664747029543, -0.00263143889605999, 0.002508483361452818, -0.0018458236008882523, 0.007643785327672958, -0.008098584599792957, 0.0664747804403305, 0.017269553616642952, 0.02391413412988186, -0.011282751336693764, 0.0034205757547169924, 0.01892882212996483, -0.004566884599626064, 0.01918156072497368, -0.011840391904115677, 0.007277010474354029, 0.02505003660917282, 0.00033468566834926605, 0.012704499065876007, -0.0016470742411911488, -0.019072435796260834, -0.04287393391132355, 0.004441595636308193, 0.03207385167479515, 0.01874612458050251, 0.001073871273547411, 0.0007134347688406706, 0.018369676545262337, -0.007646387442946434, 0.02646331675350666, -0.01943184807896614, -0.016237642616033554, 0.004156399052590132, -0.006193083710968494, 0.012865807861089706, -0.004461951088160276, 0.0031981703359633684, 0.019308608025312424, -0.010015694424510002, -0.018928397446870804, -0.0014943282585591078, 0.02800058200955391, -0.020096713677048683, 0.004231068305671215, -0.01209199894219637, -0.008096568286418915, -0.013660067692399025, -0.0050148265436291695, 0.016770347952842712, 0.027332279831171036, -0.00004444923251867294, 0.04470943659543991, 0.007721030618995428, -0.006792791187763214, 0.01439870335161686, 0.046924248337745667, 0.009204605594277382, 0.007055200636386871, -0.011167671531438828, -0.016811693087220192, 0.01852978765964508, 0.01861749216914177, -0.012390160001814365, 0.015130284242331982, -0.017782310023903847, 0.033142656087875366, -0.009496478363871574, -0.004672698676586151, 0.005910467356443405, 0.023502850905060768, 0.012841093353927135, 0.008821114897727966, -0.006165938917547464, -0.024199403822422028, 0.018326956778764725, 0.00038062548264861107, -0.020768731832504272, 0.011246924288570881, -0.0011522350832819939, 0.002740088850259781, -0.016299325972795486, -0.015145915560424328, -0.06055831536650658, 0.01064077764749527, 0.009599287994205952, 0.027079977095127106, 0.05315273627638817, 0.004496520385146141, 0.007964402437210083, -0.005395187996327877, 0.009456926956772804, 0.0057275667786598206, -0.024123776704072952, 0.02826257422566414, -0.0006133876740932465, -0.013593858107924461, 0.019981389865279198, 0.008654994890093803, -0.009105212986469269, -0.005851719528436661, -0.0811237096786499, -0.01258610375225544, -0.008351357653737068, 0.004496715497225523, 0.008620494976639748, -0.006636516191065311, 0.02221195213496685, 0.0038253823295235634, -0.025665078312158585, 0.010817313566803932, -0.0066591473296284676, 0.04607276991009712, -0.01408105343580246, 0.0122260432690382, 0.03826628252863884, -0.011462893337011337, 0.009679990820586681, -0.009441656991839409, -0.0010672986973077059, -0.012956999242305756, -0.016496552154421806, 0.0276164710521698, 0.030077561736106873, 0.013072611764073372, -0.007852835580706596, 0.03175763785839081, -0.0028995361644774675, -0.010978109203279018, -0.003303469391539693, 0.01818692684173584, -0.01807192899286747, -0.010658247396349907, -0.017557278275489807, 0.01824735291302204, -0.00027567450888454914, 0.020326241850852966, 0.005478914361447096, -0.021167166531085968, -0.011499859392642975, -0.0004574032500386238, 0.01587856560945511, 0.01224171370267868, -0.015243222936987877, 0.023913394659757614, 0.007663903757929802, -0.0004465893725864589, 0.010659498162567616, -0.01913154497742653, 0.023620670661330223, -0.001728799194097519, 0.027573920786380768, -0.005784173496067524, 0.027333125472068787, 0.024886365979909897, -0.0036848324816673994, 0.0022296784445643425, -0.036790378391742706, 0.03261367231607437, -0.011260505765676498, -0.008774353191256523, 0.03207584470510483, 0.00316948676481843, 0.017983071506023407, -0.004353465512394905, -0.015343458391726017, -0.0018709627911448479, 0.021614355966448784, 0.003632664680480957, -0.03165862709283829, 0.011197651736438274, 0.0009472165256738663, -0.01864452287554741, 0.014381236396729946, -0.012930469587445259, -0.009439749643206596, -0.023320000618696213, -0.01891326904296875, -0.002716295886784792, -0.018633976578712463, -0.02061663381755352, -0.017536692321300507, -0.005694648250937462, -0.01381414569914341, 0.004262078553438187, -0.01796022430062294, -0.029323019087314606, 0.007744826376438141, 0.04239005595445633, 0.017389047890901566, -0.017237208783626556, 0.010548125952482224, -0.010194215923547745, 0.003457309678196907, 0.007598801050335169, -0.045640528202056885, 0.004399319179356098, 0.010510691441595554, 0.022089393809437752, -0.01596253737807274, 0.012686577625572681, -0.03583626076579094, -0.002737937029451132, -0.01599329710006714, -0.01245100237429142, -0.02246268279850483, 0.013833880424499512, 0.020146653056144714, -0.022733014076948166, -0.012360794469714165, -0.008657952770590782, -0.018971074372529984, 0.023451197892427444, -0.009744830429553986, 0.011216457933187485, 0.01151006668806076, 0.02805650793015957, -0.01468767412006855, -0.0010159322991967201, 0.07142513990402222, -0.003166738199070096, 0.00669793039560318, 0.0003246326232329011, 0.03200284019112587, -0.020557640120387077, -0.0228410791605711, 0.03353046625852585, -0.02968379482626915, -0.000009911134839057922, 0.014100663363933563, 0.0012541591422632337, -0.020487405359745026, 0.01419081911444664, -0.027174219489097595, 0.0070821670815348625, -0.000984641257673502, 0.02447601966559887, 0.010180345736443996, 0.02703700214624405, -0.018829476088285446, -0.0017072802875190973, -0.0005503988359123468, -0.02743898332118988, 0.020547034218907356, 0.011486964300274849, 0.012657681480050087, -0.015957415103912354, -0.011704796925187111, 0.009404485113918781, -0.008992331102490425, 0.006570621859282255, -0.0062039573676884174, -0.015963420271873474, 0.027910247445106506, 0.025448225438594818, 0.005238518584519625, -0.007507720962166786, -0.012188664637506008, -0.009931025095283985, 0.02811821922659874, -0.015213501639664173, -0.014832129701972008, 0.013162155635654926, -0.008714500814676285, 0.006069627590477467, -0.03587288782000542, -0.0036522704176604748, 0.018814770504832268, -0.009304853156208992, -0.025161482393741608, -0.000028995797038078308, 0.016715196892619133, 0.008257023990154266, -0.0013980651274323463, 0.021865282207727432, 0.0038697603158652782, -0.01785930246114731, -0.010411880910396576, -0.015397267416119576, -0.014090033248066902, 0.053916383534669876, 0.019137442111968994, -0.034606315195560455, -0.004246721044182777, -0.02101251855492592, 0.005814016796648502, 0.0018711891025304794, -0.01365174725651741, -0.0369962640106678, 0.024068765342235565, 0.007446866482496262, -0.02462621033191681, -0.024972133338451385, 0.0034140576608479023, -0.03775685280561447, 0.018797259777784348, 0.012945388443768024, 0.017599739134311676, 0.003823409555479884, -0.005422537215054035, -0.014108733274042606, -0.005529384594410658, 0.007826479151844978, -0.00834938045591116, 0.004757859744131565, 0.0012679179199039936, -0.07456797361373901, 0.01330453623086214, -0.03508448600769043, -0.007338469848036766, -0.010024220682680607, -0.010251054540276527, -0.018046263605356216, -0.008539446629583836, 0.002179885283112526, -0.005265370011329651, 0.017207704484462738, -0.018524087965488434, -0.013691563159227371, -0.0038872009608894587, 0.011860080994665623, -0.02124481275677681, -0.037888918071985245, -0.0007529323920607567, -0.0339217334985733, -0.021182667464017868, 0.014212323352694511, 0.008403307758271694, -0.02644065022468567, -0.010307766497135162, 0.0013682538410648704, -0.08016146719455719, 0.03167201951146126, 0.007694050204008818, 0.00798126868903637, 0.0023030294105410576, 0.00843157060444355, -0.0017810624558478594, -0.013363441452383995, -0.020479518920183182, -0.017418619245290756, 0.0014517162926495075, 0.0006079841405153275, -0.03888535499572754, 0.0013447627425193787, -0.013388711959123611, -0.010594270192086697, -0.0005232673138380051, -0.01607905887067318, 0.0035435648169368505, -0.017540132626891136, 0.006766077131032944, 0.02334056980907917, -0.01244734413921833, 0.017841855064034462, -0.0071174390614032745, 0.011361455544829369, -0.017346490174531937, 0.011418743059039116, 0.01695668324828148, -0.010679286904633045, 0.018442582339048386, -0.004681662656366825, 0.00010283757001161575, -0.014474721625447273, -0.00016702967695891857, -0.016477297991514206, 0.007675106171518564, -0.003918615635484457, 0.02234736829996109, -0.03024160861968994, -0.0023928708396852016, -0.03141165152192116, -0.03990190848708153, 0.0036436193622648716, -0.008899908512830734, -0.015290437266230583, 0.008530824445188046, -0.007943705655634403, 0.008776266127824783, -0.01897008717060089, 0.013284511864185333, 0.0005561560392379761, -0.002295266604050994, -0.006971066817641258, -0.009181383065879345, 0.002573140198364854, 0.0028559938073158264, 0.001555777620524168, 0.014311685226857662, -0.012892303988337517, 0.004168440122157335, 0.028204143047332764, 0.005698313470929861, 0.0710688903927803, 0.014180641621351242, 0.001370469806715846, -0.002498347545042634, -0.0008550961501896381, 0.003284632693976164, -0.01075891312211752, 0.010461287572979927, -0.04407132416963577, -0.0325484573841095, 0.0015241054352372885, -0.027338629588484764, -0.022981911897659302, 0.019307026639580727, -0.014583783224225044, 0.011276984587311745, 0.0020774113945662975, 0.008224206045269966, -0.019185703247785568, -0.023518990725278854, -0.02616584673523903, 0.014331605285406113, -0.009592738933861256, -0.013876416720449924, -0.023742662742733955, -0.007797673344612122, -0.00443995650857687, 0.01649661920964718, -0.0021707990672439337, -0.014196598902344704, 0.0042749010026454926, -0.00025405921041965485, 0.0006592408753931522, -0.019336136057972908, 0.019319521263241768, 0.025663815438747406, 0.019122518599033356, 0.01030903309583664, -0.013698544353246689, -0.046609655022621155, 0.04071073979139328, 0.015150392428040504, -0.0013796371640637517, -0.015074220485985279, -0.024663977324962616, 0.030778363347053528, 0.011051131412386894, -0.02430759370326996, -0.00836947001516819, 0.020460344851017, 0.0026820823550224304, 0.0004183728015050292, 0.010071218945086002, 0.007956848479807377, 0.012883717194199562, 0.007363674230873585, -0.0075231376104056835, 0.014932164922356606, -0.012818996794521809, -0.0001837257295846939, -0.01124043483287096, -0.01748567819595337, -0.033902283757925034, -0.00593466404825449, 0.032952383160591125, 0.011295308358967304, 0.008664172142744064, -0.02579129859805107, -0.02314032055437565, 0.01970653422176838, -0.0032533016055822372, -0.02587585523724556, 0.009870019741356373, -0.023112962022423744, 0.032279446721076965, 0.003561212681233883, 0.01043635606765747, -0.025474941357970238, 0.020809747278690338, -0.010779592208564281, -0.009722062386572361, 0.0006319745443761349, -0.03142944723367691, 0.034811995923519135, -0.00045154173858463764, -0.04206576943397522, -0.008873162791132927, 0.023502007126808167, -0.009079167619347572, 0.009318137541413307, -0.011504452675580978, -0.01672082394361496, -0.003505176864564419, 0.02528243139386177, 0.004594508092850447, 0.03509422391653061, -0.00780086312443018, 0.005000706762075424, -0.014107093214988708, -0.007503995671868324, -0.00673039210960269, -0.019031884148716927, 0.01539534516632557, -0.0015751514583826065, -0.008869735524058342, -0.028571495786309242, 0.027229581028223038, 0.015098444186151028, -0.03056778386235237, 0.006490823347121477, -0.04407338798046112, 0.005207855720072985, 0.012956658378243446, -0.02095087245106697, 0.007691850420087576, 0.014447864145040512, -0.021784845739603043, 0.027246015146374702, 0.016217375174164772, -0.009625280275940895, -0.015802737325429916, 0.011365598067641258, -0.038947079330682755, 0.011762533336877823, -0.038889989256858826, -0.014997320249676704, -0.014602706767618656, 0.0452088788151741, -0.02168607898056507, -0.00912112183868885, 0.012065678834915161, -0.005203095730394125, 0.015335558913648129, 0.0031677228398621082, -0.0009151651756837964, -0.021659914404153824, 0.00619974359869957, 0.0063645862974226475, 0.010313821956515312, -0.0064368112944066525, 0.0012687165290117264, -0.023657843470573425, 0.008687850087881088, 0.013047166168689728, 0.007574859075248241, -0.014059798792004585, 0.014864802360534668, 0.03153637796640396, 0.013101046904921532, -0.0044065117835998535, 0.007390440441668034, 0.0002998095005750656, -0.02283584326505661, -0.007917928509414196, -0.014096970669925213, 0.004616329446434975, 0.0015765286516398191, 0.023231642320752144, -0.000689846696332097, -0.03523371368646622, -0.02020997554063797, 0.04420515149831772, 0.006046437192708254, 0.009308945387601852, 0.010872408747673035, 0.03067186288535595, 0.0007676288369111717, 0.04074616730213165, -0.030811194330453873, 0.03211600333452225, 0.022736549377441406, 0.010249718092381954, 0.0013853157870471478, 0.01986600086092949, -0.012269126251339912, -0.0010115641634911299, -0.0030207494273781776, 0.006463323719799519, -0.010017802938818932, 0.017220670357346535, 0.0010992428287863731, -0.04130987077951431, 0.02146722376346588, -0.010820786468684673, -0.016036612913012505, -0.020234698429703712, -0.011008855886757374, -0.010500052012503147, 0.010764498263597488, 0.03525480628013611, -0.004715493880212307, 0.003953729756176472, -0.02731003612279892, 0.019500605762004852, -0.006237767171114683, 0.023334503173828125, -0.004274754785001278, -0.01011560671031475, -0.009956534951925278, 0.012351475656032562, 0.0008289976976811886, 0.006819494999945164 ]
[ -0.274615079164505, -0.32523423433303833, 0.5903487801551819, 0.012022090144455433, -0.1764104813337326, 0.5163593888282776, -0.037335027009248734, -0.26518476009368896, -0.3616490662097931, -0.595098078250885, -0.031092505902051926, 0.1320284903049469, -0.6877204775810242, -0.0010399960447102785, 0.18953464925289154, 0.5334757566452026, 0.3257672190666199, 0.35830357670783997, -0.31996798515319824, -0.6851436495780945, -0.026741884648799896, -0.25764891505241394, 1.1929289102554321, 0.16022905707359314, 0.7999919056892395, -0.33359113335609436, 0.34414607286453247, 0.26370275020599365, 0.25101912021636963, 0.05296790599822998, -0.5019813776016235, 0.6567921042442322, -0.2495431751012802, 0.20540347695350647, -0.15875589847564697, 0.05752778425812721, -0.34320807456970215, -0.05388500541448593, 0.45734232664108276, -0.43689674139022827, -0.26908496022224426, 0.20682814717292786, -0.5308234691619873, 0.2602593004703522, -0.31274598836898804, 0.24826832115650177, -1.5074542760849, 0.25050607323646545, -0.3375219404697418, -0.2600337266921997, 0.13008742034435272, 0.6342326998710632, 0.23046094179153442, -0.023219967260956764, -0.10674553364515305, 0.05252940580248833, -0.9349237680435181, -0.11496395617723465, 0.3924862742424011, -0.8681290149688721, 0.2037755697965622, 0.37125831842422485, -0.07006578147411346, 0.35590118169784546, 0.19022272527217865, 0.1581323891878128, -0.10845501720905304, -0.1643730252981186, -0.4722888767719269, -0.2137896865606308, 0.1237788200378418, -0.38501206040382385, 0.18723896145820618, -0.011372066102921963, -0.13113443553447723, 0.0201379656791687, -0.0974365696310997, -0.05841531977057457, 0.05420967936515808, 0.17623382806777954, -0.12703214585781097, -0.02159114181995392, 0.49994856119155884, 0.3509734869003296, 0.5186563730239868, -0.04811844974756241, -0.12186900526285172, 0.68373042345047, -0.09736470878124237, -0.012910912744700909, -0.1341511458158493, -0.26600468158721924, 0.39322784543037415, 0.1546170860528946, 0.41853469610214233, 0.17133821547031403, 0.3139170706272125, -0.04236244782805443, -0.06506729871034622, -0.17141093313694, -0.075942263007164, -0.1319781392812729, -0.10601282119750977, -0.2440532147884369, -0.19782988727092743, -0.4605425298213959, -0.2686236500740051, -0.34508612751960754, -0.15203045308589935, -0.03269161283969879, -0.455980509519577, -0.24665719270706177, 0.16700276732444763, -0.040304094552993774, 0.1296108365058899, -0.005483066663146019, -0.1673547327518463, -0.20807036757469177, -0.012757803313434124, 0.2236776053905487, 0.2654930353164673, 0.8353618383407593, -0.16885922849178314, 0.14591361582279205, -0.156347393989563, -0.46995896100997925, 0.16287274658679962, -0.12669737637043, -0.5993549823760986, 0.32457950711250305, 0.29804253578186035, 1.097717523574829, -0.11158192902803421, 0.31817832589149475, -0.24506865441799164, -0.19118669629096985, 0.08738494664430618, 0.0019730248022824526, 0.6491078734397888, 0.07981686294078827, -0.6242910623550415, -0.3843214213848114, -0.005966867785900831, -0.2086896449327469, 0.19512805342674255, -1.0072487592697144, -0.015934161841869354, -0.3357503116130829, -0.17532628774642944, -0.4625277519226074, 0.01064817514270544, -0.21659474074840546, -0.4618309736251831, -0.2679717242717743, 0.13337968289852142, 0.0832056999206543, 0.39541688561439514, -0.23293805122375488, -0.04288896173238754, 0.10733254253864288, -0.43720242381095886, -0.030979584902524948, -0.2470751702785492, -0.10948575288057327, 0.4513133466243744, -0.19621717929840088, 0.44148221611976624, -0.01070156879723072, 0.004568443633615971, 0.1927388459444046, -0.061481624841690063, -0.10325225442647934, 0.3615635931491852, -0.07424204051494598, -0.04569762200117111, -0.19940288364887238, 0.22460220754146576, 0.10788260400295258, -0.26428061723709106, -0.17274603247642517, -0.6865751147270203, 0.33112671971321106, -0.11448048055171967, -0.3353976309299469, -0.01696394383907318, 0.006368383765220642, 0.380731463432312, -0.18872682750225067, -0.004284466616809368, -0.16225753724575043, 0.49583715200424194, -0.07931516319513321, 0.4764484763145447, -0.33988648653030396, 1.4693121910095215, -0.013648212887346745, -0.43677425384521484, 0.8945507407188416, -0.05533356964588165, -0.013693411834537983, -0.4978850483894348, -0.13775256276130676, 0.5266581773757935, -0.47660139203071594, -0.1467781811952591, 0.18204323947429657, -0.08461306989192963, -0.24826796352863312, 0.1667759120464325, 0.02516978420317173, 0.1705230325460434, -0.5340787768363953, -0.11064532399177551, -0.24251174926757812, 0.4808996319770813, -0.5303664803504944, -0.19387862086296082, 0.20340223610401154, -0.32087433338165283, 0.06355243176221848, 0.662274181842804, -0.5131744742393494, 0.36687013506889343, 0.7575159668922424, 0.053564682602882385, 0.4924103915691376, 0.5626310706138611, -0.14093755185604095, 0.8063479661941528, -0.2675052285194397, 0.46132880449295044, -0.20938141644001007, -0.037890125066041946, -0.16569113731384277, -0.4886550307273865, 0.21793563663959503, 0.4846328794956207, -0.06261074542999268, -0.44712960720062256, -0.25581830739974976, -0.13847556710243225, 0.7220703959465027, -0.7157118916511536, 0.270841121673584, -0.056872643530368805, -0.4347371757030487, -0.048256002366542816, 0.6039468050003052, -0.7103836536407471, -0.20598791539669037, 0.07870931178331375, 0.5849811434745789, -0.3965279161930084, -0.7283997535705566, 0.39848798513412476, -0.018360581248998642, -0.0397879034280777, 0.07020390778779984, 0.24500802159309387, -0.15861360728740692, -0.4847891628742218, 0.07591284066438675, -0.35225626826286316, 0.3094922602176666, -0.4566625654697418, 0.16172470152378082, -0.9286826252937317, -0.29327091574668884, 1.3052269220352173, 0.847704291343689, 0.7904319167137146, 0.13045431673526764, -0.7607282996177673, 0.153672993183136, -0.403109073638916, -0.5219698548316956, 0.13882815837860107, -0.022429224103689194, -0.2504149377346039, -0.5141122937202454, -0.5140472054481506, 0.6159746050834656, 0.8445191979408264, 0.07691113650798798, 0.07975519448518753, 0.06441112607717514, 0.004804519005119801, 0.17512407898902893, 0.04209020361304283, -0.42512568831443787, -0.40879401564598083, -0.11157044768333435, 0.05082268267869949, -0.34007662534713745, 0.07479196041822433, 0.6278114318847656, 0.08127504587173462, 0.6883993148803711, 0.794889509677887, 0.14394798874855042, -0.2938961088657379, -0.21129506826400757, -0.4025995135307312, -0.26428288221359253, 0.12069758027791977, -0.4534011483192444, -0.3539614975452423, 0.4504188597202301, -5.914660453796387, -0.19872833788394928, -0.07879602164030075, 0.30687037110328674, 0.3554391860961914, -0.27674147486686707, 0.7043032050132751, 0.3348553776741028, 0.06238716468214989, 0.3175906836986542, -0.31974661350250244, 0.4357336461544037, -0.3574562072753906, -0.14209210872650146, -0.20374946296215057, 0.024656780064105988, 0.08048127591609955, -0.2632285952568054, 0.5206369757652283, -0.266799658536911, -0.016332974657416344, -0.2884907126426697, 0.31966152787208557, 0.7885479927062988, -0.10612696409225464, 0.4267403185367584, -0.3859294056892395, 0.05948655679821968, -0.2685685455799103, -0.37182727456092834, -0.47801515460014343, -0.7653096318244934, 0.06964533030986786, -0.4774393141269684, 1.0383166074752808, -0.17789939045906067, -0.08093912154436111, 0.041824065148830414, 0.019335070624947548, -0.5347841382026672, 0.31965020298957825, 0.46366047859191895, -0.3997688293457031, 0.08827031403779984, 0.36024248600006104, -0.4473465085029602, -0.21941295266151428, 0.08139661699533463, -0.30073270201683044, 0.5840345025062561, 0.11224325746297836, -0.3495261073112488, 0.2485872209072113, 0.388043612241745, 0.7579386234283447, 0.16591434180736542, -0.3049894869327545, -0.18434001505374908, -0.045566972345113754, 0.01278662122786045, -0.20355552434921265, -0.23990894854068756, -0.41071030497550964, -0.24380160868167877, -0.2208908349275589, 0.3301951587200165, -0.8761114478111267, -0.15009158849716187, 0.820659875869751, -0.28855985403060913, 0.06759441643953323, 0.13806340098381042, 0.07171384990215302, -0.7049668431282043, 0.7339213490486145, -0.12964701652526855, -0.02000843919813633, 0.15931682288646698, 0.22622746229171753, 0.35050031542778015, -0.5507766008377075, 0.279159277677536, 0.15260006487369537, -0.4680579900741577, 0.14777660369873047, -0.48590797185897827, -0.4199444055557251, 0.01080088410526514, -0.5247489809989929, 0.40720877051353455, 0.5177808403968811, -0.2523998022079468, 0.37157580256462097, 0.03903953731060028, 0.01183924451470375, 0.10210715234279633, -0.035585518926382065, 0.4174606204032898, 0.010843174532055855, 0.032112881541252136, 1.3089121580123901, 0.08239448815584183, -0.5312709808349609, -0.6713364124298096, 0.14793848991394043, 0.35325461626052856, -0.5557957887649536, 0.6829301118850708, 0.553674042224884, -0.16149014234542847, 0.15072062611579895, 0.12222558259963989, -0.15925246477127075, -0.4800034463405609, 0.49084508419036865, 0.32086342573165894, -0.917158842086792, 0.06824164092540741, 0.6863676905632019, -0.09426683932542801, -0.18276719748973846, 0.03352564573287964, -0.44417786598205566, 0.24988096952438354, 0.38762468099594116, 0.17143253982067108, 0.3806542158126831, 0.5449259877204895, -0.3660067319869995, -0.12173928320407867, 0.48041626811027527, 0.03614160791039467, -0.2829858660697937, -0.0896705687046051, 0.3759930729866028, -0.5178036689758301, -0.2510075867176056, -0.0038999433163553476, 0.18583618104457855, -0.5481421947479248, 0.010580583475530148, -0.07093119621276855, -0.07971607148647308, -0.03479510173201561, 0.09424835443496704, 0.0072422451339662075, -0.16538111865520477, 0.34264159202575684, -0.25941944122314453, 0.33448049426078796, 0.35690248012542725, -0.08066193014383316, -0.002709408523514867, -0.21878308057785034, 0.04382436349987984, -0.07412482798099518, 0.21394816040992737, 0.00419281143695116, 0.760554850101471, -0.6110289096832275, 0.16196198761463165, -0.02067445032298565, -0.6322561502456665, -0.04680877923965454, -0.4539521634578705, -0.36903852224349976, -0.257469117641449, -0.7369677424430847, 0.13463309407234192, 0.2371227741241455, -0.24012452363967896, -0.29459425806999207, -0.11076197773218155, -0.21636785566806793, 0.1469472050666809, -0.5675045251846313, -0.165376216173172, 0.16969558596611023, 0.1987694650888443, -0.10497982054948807, -0.22102974355220795, -0.4199025630950928, -0.12968426942825317, 0.3811000883579254, 0.6618379950523376, 0.16034449636936188, 0.28466272354125977, 0.4016740024089813, -0.08075551688671112, -0.511780858039856, 0.08548717945814133, 0.5558279752731323, 0.11986862868070602, 0.1021883487701416, 0.12629705667495728, 0.15682725608348846, 0.1477525383234024, 0.8276479244232178, -0.3764091432094574, -0.23396609723567963, 0.32628729939460754, 0.3084498345851898, -0.2975005805492401, 0.24205376207828522, 0.44447603821754456, 0.5025405287742615, -0.01874149590730667, -0.10026080161333084, -0.05994568392634392, -0.14254650473594666, -0.3566204011440277, -0.2609299123287201, -0.048862356692552567, 0.5070325136184692, -0.2633376121520996, -0.005444721318781376, 0.3477851450443268, -0.6934396028518677, -0.683441162109375, 0.5198788642883301, -0.11011543869972229, 0.2718437910079956, -0.545142650604248, -0.11767647415399551, -0.3186948299407959, -0.03538578376173973, 0.2582990825176239, -0.8530573844909668, 0.19922950863838196, 0.2729870080947876, 0.03225426748394966, -0.23056600987911224, -0.03675354644656181, -0.011161603033542633, 0.013811551965773106, -0.0726541206240654, 0.18256665766239166, 0.04102489724755287, -0.4345332384109497, 0.26090964674949646, 0.35755252838134766, 0.3603747487068176, -0.4179263114929199, -0.23721875250339508, 0.19290341436862946, 0.7362844347953796, 0.4645984172821045, -0.6242420077323914, -0.6908636689186096, 0.2140558511018753, 1.177978754043579, -0.1476058065891266, 0.13391494750976562, 0.6774916648864746, 0.6296836733818054, -0.2222391813993454, -0.043997831642627716, -0.027932319790124893, 0.4772131145000458, 0.4466497600078583, 0.09767375886440277, 0.06458155065774918, -0.41460421681404114, -0.01404784806072712, 0.18756283819675446, 0.08936053514480591, -0.45469701290130615, -0.7917382717132568, 0.45623233914375305, -0.007470779120922089, 0.27864158153533936, 0.42677047848701477, 0.53943932056427, -0.1409250795841217, -0.14517903327941895, 0.592034101486206, -0.2626151144504547, -0.0229033175855875, -0.14189696311950684, -0.0933167114853859, -0.4979541599750519, -0.4251876771450043, 0.03212575986981392, -0.4048215448856354, 0.4044410288333893, -0.6837828755378723, 0.16895897686481476, -0.5463525652885437, 0.025553781539201736, 0.29976338148117065, -0.006626426707953215, -0.1656569093465805, -0.6056498289108276, -0.47011223435401917, -0.01330176368355751, 0.03930024430155754, -0.03360487148165703, 0.1047905907034874, -0.19301347434520721, -0.0021433590445667505, -0.9058540463447571, 0.26652514934539795, 0.17890165746212006, -0.789347231388092, 0.14474260807037354, 0.3862345218658447, 0.13113944232463837, -0.285371333360672, -0.4355156421661377, -0.402519166469574, 0.3272894024848938, -0.21768513321876526, 0.09239871799945831, 0.29933372139930725, -0.18656882643699646, 0.0800015926361084, 0.3033865690231323, -0.29867878556251526, 0.32110685110092163, 0.7105820178985596, 0.4943157434463501, 0.7316740155220032, 0.0663430392742157, -0.31927695870399475, 0.06373796612024307, 0.454080730676651, 0.4253261387348175, 0.21005569398403168, 0.25986140966415405, 0.5278064012527466, 0.544977605342865, 0.4646776020526886, -0.4919882118701935, 0.4581018090248108, 0.3958200514316559, -0.007773077115416527, 0.3308790624141693, -0.45338138937950134, -0.506232738494873, 0.33885303139686584, 0.4139580726623535, 0.6433975696563721, -0.6343538761138916, -0.2797727584838867, 0.2661842703819275, 0.4361846148967743, 0.5682098865509033, 0.08472418785095215, -0.14380744099617004, 0.6199865937232971, 0.5502569079399109, -0.5105111598968506, -0.7322906851768494, -0.07093121111392975, -0.6046700477600098, 0.09904356300830841, 0.5937448740005493, -0.4494834840297699, -0.5867300629615784, 0.10788116604089737, -0.20708586275577545, 0.8603224158287048, -0.3375644385814667, 0.13013337552547455, 0.13717021048069, 0.29443278908729553, 0.3451608121395111, -0.3219367563724518, 0.05808436870574951, -0.34991517663002014, 0.029435940086841583, 0.27579227089881897, -0.26404112577438354, -0.13469888269901276, 0.08183752000331879, -0.3065416216850281, 0.3760713040828705, 0.1628442108631134, -0.11377464234828949, 0.36730509996414185, -0.17012466490268707, 0.4510795772075653, -0.18602481484413147, -0.4503141939640045, 0.11785897612571716, -0.5773985385894775, 0.06822720915079117, -0.5147672295570374, -0.14851313829421997, 0.18601539731025696, -0.20707479119300842, -0.7416324615478516, 0.11292403191328049, 0.23328550159931183, 0.5634161829948425, -0.21920299530029297, -0.215834379196167, 0.4032486081123352, 0.07948359102010727, 0.17278578877449036, 0.02417738363146782, 0.422794908285141, -0.029333239421248436, 0.2570156157016754, -0.4571850597858429, 0.3359670341014862, -0.7812493443489075, -0.3626013696193695, -0.5454452633857727, 0.020958544686436653, 1.2349998950958252, 0.6331889033317566, -0.4248068928718567, 0.16162168979644775, 0.4386434555053711, 0.18125511705875397, 0.4194056987762451, -0.6800236701965332, -0.23693761229515076, -0.49206796288490295, 0.016349805518984795, -0.5357846021652222, 0.4776459038257599, 0.5267490148544312, -0.26270556449890137, -0.35191115736961365, 0.3414333760738373, -0.08390949666500092, -0.5479450225830078, 0.40889331698417664, -0.3122650682926178, 0.017588244751095772, -0.36224961280822754, 0.13845103979110718, -0.3627344071865082, 0.3624497652053833, -0.46704578399658203, -0.5163191556930542, 0.091461680829525, -0.2061176300048828, 0.5048074126243591, -0.2178647220134735, 0.06978698074817657, 0.1944926232099533, -0.19896309077739716, 0.18732282519340515, -0.10695450007915497, -0.5265242457389832, -0.6727230548858643, -0.1007402241230011, 0.030109215527772903, -0.5692821741104126, 0.08988536894321442, 0.19256435334682465, -0.04167582467198372, -0.03252153843641281, -0.45844072103500366, -0.2772386074066162, -0.5436680912971497, 0.14926591515541077 ]
5-Hydroxymethylcytosine (5-hmC) may represent a new epigenetic modification of cytosine. While the dynamics of 5-hmC during neurodevelopment have recently been reported, little is known about its genomic distribution and function(s) in neurodegenerative diseases such as Huntington's disease (HD). We here observed a marked reduction of the 5-hmC signal in YAC128 (yeast artificial chromosome transgene with 128 CAG repeats) HD mouse brain tissues when compared with age-matched wild-type (WT) mice, suggesting a deficiency of 5-hmC reconstruction in HD brains during postnatal development. Genome-wide distribution analysis of 5-hmC further confirmed the diminishment of the 5-hmC signal in striatum and cortex in YAC128 HD mice. General genomic features of 5-hmC are highly conserved, not being affected by either disease or brain regions. Intriguingly, we have identified disease-specific (YAC128 versus WT) differentially hydroxymethylated regions (DhMRs), and found that acquisition of DhmRs in gene body is a positive epigenetic regulator for gene expression. Ingenuity pathway analysis (IPA) of genotype-specific DhMR-annotated genes revealed that alternation of a number of canonical pathways involving neuronal development/differentiation (Wnt/β-catenin/Sox pathway, axonal guidance signaling pathway) and neuronal function/survival (glutamate receptor/calcium/CREB, GABA receptor signaling, dopamine-DARPP32 feedback pathway, etc.) could be important for the onset of HD. Our results indicate that loss of the 5-hmC marker is a novel epigenetic feature in HD, and that this aberrant epigenetic regulation may impair the neurogenesis, neuronal function and survival in HD brain. Our study also opens a new avenue for HD treatment; re-establishing the native 5-hmC landscape may have the potential to slow/halt the progression of HD.
[ -0.014239845797419548, 0.0014649388613179326, -0.01780356839299202, 0.008069106377661228, 0.007397519424557686, -0.028235625475645065, 0.009434565901756287, -0.00783047266304493, -0.007741520181298256, -0.014180980622768402, -0.007188286632299423, -0.002485075034201145, -0.001770018832758069, 0.016719739884138107, -0.035246431827545166, 0.02363971248269081, -0.025441590696573257, -0.006831350736320019, 0.009830599650740623, 0.003358166664838791, -0.017826000228524208, -0.00029935454949736595, 0.00821761041879654, -0.003023879136890173, 0.027852509170770645, 0.005135769955813885, -0.0025757099501788616, 0.01695462316274643, -0.0009189846459776163, -0.018123097717761993, 0.001842837780714035, 0.010097634047269821, 0.0002668555825948715, 0.014067386277019978, 0.009337971918284893, -0.002092642243951559, -0.0028011698741465807, 0.02148442342877388, 0.012520398013293743, -0.004725005943328142, 0.015007976442575455, -0.012426838278770447, -0.00014752618153579533, 0.006902134511619806, -0.0062052421271800995, 0.027865981683135033, -0.0027665868401527405, 0.01572662591934204, 0.027043335139751434, 0.004776415415108204, -0.0037824329920113087, -0.014085987582802773, -0.008107850328087807, -0.002964233048260212, -0.004687842447310686, 0.0019205191638320684, 0.015555832535028458, 0.00047832727432250977, 0.0011762459762394428, -0.019373569637537003, 0.016088983044028282, -0.01929161325097084, 0.0022252658382058144, -0.02722407504916191, -0.02045113779604435, -0.06715980172157288, 0.02322883903980255, -0.013232646510004997, 0.009406812489032745, 0.0013716639950871468, 0.007595117203891277, 0.010200034826993942, 0.013890613801777363, 0.02812364511191845, -0.016471244394779205, 0.003057965077459812, -0.008367997594177723, 0.021292462944984436, -0.0035731513053178787, 0.00831548124551773, 0.001750091789290309, -0.012299449183046818, 0.031871020793914795, 0.004380782134830952, 0.007232107687741518, -0.02718883752822876, -0.03355707973241806, -0.0006694954354315996, 0.0015736245550215244, -0.010193470865488052, 0.02375267818570137, 0.008018869906663895, -0.014142803847789764, -0.007275636773556471, -0.015785248950123787, 0.01676510088145733, 0.0004667544271796942, -0.004002362489700317, -0.0020142642315477133, -0.011835724115371704, -0.010660351254045963, -0.002089997287839651, 0.013954420574009418, -0.014415713027119637, -0.012796396389603615, 0.004291668068617582, -0.001496125478297472, -0.01309072133153677, 0.006626970134675503, 0.006591409910470247, -0.018987193703651428, 0.0038060666993260384, -0.006294481456279755, 0.031283900141716, 0.039804864674806595, -0.008471807464957237, -0.003437662497162819, 0.027508335188031197, 0.009737434796988964, -0.014665156602859497, -0.013668862171471119, -0.0041132173500955105, 0.015216965228319168, -0.02071561850607395, 0.002803604584187269, -0.0067909592762589455, -0.004492705222219229, -0.0013699582777917385, -0.006520820781588554, -0.0138264000415802, -0.008454736322164536, 0.008666511625051498, -0.007035665214061737, -0.019483428448438644, 0.007839205674827099, -0.010561462491750717, -0.013530319556593895, -0.008509829640388489, -0.00783418957144022, -0.01671682670712471, 0.00857606902718544, 0.011063857935369015, 0.00982518121600151, -0.0004503296222537756, 0.0016171294264495373, -0.00863859336823225, -0.015904348343610764, 0.01076799351722002, -0.014192863367497921, -0.029828213155269623, 0.0017109354957938194, 0.006327647715806961, -0.025320876389741898, -0.009510363452136517, -0.010092711076140404, 0.020984189584851265, -0.009024892002344131, -0.011976974084973335, -0.0037687071599066257, -0.0007238248363137245, 0.01910720206797123, -0.03562495484948158, 0.011566245928406715, 0.007730524986982346, 0.013139976188540459, 0.020184362307190895, -0.0012183792423456907, -0.0024885074235498905, 0.015710771083831787, 0.003777838544920087, -0.005027586594223976, 0.011011984199285507, -0.009212984703481197, 0.01137394830584526, -0.01650107465684414, -0.00493623549118638, 0.00020552892237901688, 0.006797336041927338, 0.006790234707295895, 0.06658550351858139, -0.011952913366258144, 0.0450509712100029, -0.010828192345798016, 0.013401978649199009, 0.0024601593613624573, -0.012299934402108192, 0.015936702489852905, -0.002011275850236416, 0.0017135986126959324, -0.0003027934581041336, 0.001202862709760666, -0.0076870908960700035, -0.032409146428108215, 0.02491527795791626, -0.014880184084177017, 0.002338389866054058, 0.01792445406317711, 0.015220711007714272, 0.005522433202713728, 0.006945654284209013, 0.01562570407986641, -0.018454471603035927, 0.011226057074964046, -0.024236897006630898, 0.039228398352861404, -0.014935759827494621, 0.011460412293672562, -0.003366873599588871, -0.008475370705127716, -0.017318245023489, 0.014510189183056355, 0.014955147169530392, -0.0046652453020215034, -0.00222394079901278, -0.007006046827882528, 0.003048291429877281, 0.00997463334351778, 0.03343893587589264, -0.009311249479651451, -0.010661001317203045, 0.00489097461104393, -0.005750453099608421, 0.02953665517270565, 0.009774293750524521, 0.0035486887209117413, -0.007285636849701405, 0.015935221686959267, 0.009266337379813194, -0.00685409689322114, -0.0006656937766820192, -0.020760580897331238, -0.020098885521292686, -0.012490496970713139, 0.017578229308128357, 0.02695651352405548, -0.0007008265238255262, 0.011957433074712753, -0.02384195104241371, 0.010247119702398777, -0.013735647313296795, -0.009626158513128757, 0.004617126192897558, 0.03794114291667938, -0.022496312856674194, -0.02142423391342163, 0.011504965834319592, 0.003224939340725541, -0.0072550093755126, 0.010129161179065704, -0.009366059675812721, 0.004896271508187056, -0.01257451344281435, -0.010654710233211517, -0.0024481334257870913, -0.0062428549863398075, -0.012630163691937923, -0.030293617397546768, 0.018890447914600372, 0.023342110216617584, 0.017451047897338867, -0.008029526099562645, 0.004544699564576149, 0.004305511713027954, 0.016418084502220154, -0.017771610990166664, 0.00802225898951292, 0.00025302101857960224, 0.0105765201151371, -0.009722230024635792, 0.005331946071237326, 0.0061787450686097145, -0.011602621525526047, 0.003583537181839347, -0.08193275332450867, -0.007903754711151123, -0.0035823779180645943, -0.020304271951317787, 0.011247605085372925, -0.010421767830848694, -0.010989964008331299, 0.004633091390132904, -0.013516752049326897, -0.02235543541610241, 0.010110280476510525, 0.013543914072215557, -0.008080920204520226, -0.014571640640497208, -0.017738185822963715, 0.005133261904120445, 0.011722322553396225, -0.0029610313940793276, 0.01017495896667242, -0.03243211284279823, 0.028773557394742966, -0.01469723042100668, -0.001742047257721424, 0.0065381815657019615, -0.010595553554594517, 0.00983141828328371, 0.0014575165696442127, -0.0041197980754077435, -0.009834112599492073, 0.0033985693007707596, -0.021163523197174072, -0.013288825750350952, 0.011982806958258152, -0.02203066274523735, 0.009602870792150497, -0.01853327266871929, -0.005481470376253128, 0.013549979776144028, -0.008681253530085087, 0.020604286342859268, -0.03860544413328171, -0.007585035637021065, 0.034577298909425735, -0.008883005939424038, -0.004080530721694231, -0.0014887363649904728, 0.03178069740533829, -0.01834065467119217, 0.011562415398657322, -0.014156576246023178, -0.023972537368535995, -0.0021665936801582575, 0.00027179624885320663, 0.012852070853114128, -0.009361926466226578, -0.0166030116379261, 0.022654425352811813, 0.012225394137203693, -0.010928962379693985, -0.004786042496562004, -0.0013346849009394646, -0.018198858946561813, 0.001913775922730565, -0.012976295314729214, -0.0015115556307137012, 0.00439420435577631, 0.007585986517369747, -0.011574671603739262, -0.019735554233193398, 0.009138369001448154, -0.020461425185203552, -0.005552995018661022, -0.006095747463405132, -0.001060830312781036, 0.0028204787522554398, -0.004948357120156288, -0.009276296943426132, -0.003901534713804722, -0.01903928816318512, -0.020697271451354027, -0.01732693985104561, -0.0014333772705867887, -0.03167975693941116, -0.01959036849439144, -0.002784586511552334, -0.013646937906742096, 0.004997157957404852, 0.03201941400766373, 0.00659909937530756, -0.010952502489089966, -0.019034888595342636, 0.02485044300556183, -0.0031349644996225834, 0.012175152078270912, 0.01432823110371828, -0.03303970396518707, 0.017406363040208817, 0.010581595823168755, 0.032277852296829224, 0.00569976307451725, -0.0024725771509110928, 0.0036182054318487644, 0.0024534279946237803, -0.010481977835297585, 0.029324490576982498, 0.013047788292169571, -0.012498249299824238, -0.00287600327283144, 0.00443667359650135, -0.0007686457829549909, 0.020364027470350266, 0.0007556239143013954, -0.003729452844709158, 0.006881236098706722, 0.0048361653462052345, 0.0008514135261066258, -0.00028297072276473045, -0.004375131335109472, 0.07272353768348694, 0.018207158893346786, -0.0032530962489545345, -0.01065560057759285, 0.00389000098221004, 0.003137904219329357, -0.013182293623685837, 0.022772707045078278, -0.02235034480690956, 0.019775252789258957, 0.011222053319215775, -0.011449018493294716, 0.02339143306016922, -0.01132983434945345, 0.011542866006493568, -0.004532527644187212, -0.00431845523416996, -0.00018372433260083199, 0.004651169758290052, 0.002101536374539137, 0.0028135990723967552, -0.004340346436947584, -0.00220467709004879, 0.006701263599097729, 0.02012799121439457, -0.0450834184885025, 0.020303761586546898, -0.013464841991662979, 0.0031173923052847385, 0.009556828066706657, 0.008346021175384521, 0.024898488074541092, -0.008239821530878544, 0.016912737861275673, 0.02663944475352764, -0.0002154319081455469, 0.014187268912792206, -0.01087192166596651, -0.0027754621114581823, 0.002238226355984807, -0.008003100752830505, -0.01101638562977314, -0.013695359230041504, 0.004048698581755161, -0.012127529829740524, -0.0002011563628911972, 0.028330180794000626, -0.008661158382892609, 0.001067043049260974, 0.002446856116876006, -0.0024772293400019407, -0.019544020295143127, 0.0076976921409368515, -0.0013378493022173643, 0.010115417651832104, -0.003940983675420284, -0.0034661120735108852, -0.00257281307131052, -0.007098841015249491, -0.016705846413969994, -0.013151492923498154, -0.015129897743463516, 0.016400067135691643, -0.018285084515810013, 0.01699056103825569, -0.001004637568257749, -0.01819518208503723, 0.01757849007844925, 0.0060065798461437225, -0.0001445966772735119, -0.0011014994233846664, -0.012634050101041794, -0.007422986906021833, -0.028886668384075165, -0.011657873168587685, 0.0032642134465277195, 0.010720869526267052, -0.006595767103135586, 0.006399764213711023, 0.015056549571454525, 0.018339287489652634, 0.010469190776348114, -0.02263239584863186, 0.016517164185643196, 0.006098720245063305, 0.019481217488646507, -0.010666297748684883, -0.07469835877418518, -0.021684497594833374, 0.0008887139847502112, -0.0027485075406730175, 0.017325062304735184, -0.009110866114497185, -0.01367083191871643, 0.000877829035744071, 0.006340453866869211, 0.005066697020083666, 0.0174509659409523, 0.007437737192958593, 0.0008113435469567776, 0.0007100359071046114, 0.008916190825402737, 0.024406705051660538, -0.02752414532005787, -0.00806260947138071, -0.014165548607707024, 0.007997454144060612, -0.024401651695370674, -0.017853064462542534, -0.010246094316244125, 0.0013386589707806706, -0.012684490531682968, -0.0817224457859993, 0.017720414325594902, -0.006571503356099129, -0.012996322475373745, -0.021769702434539795, 0.0061696115881204605, 0.009833925403654575, -0.016195110976696014, -0.02173609659075737, -0.014951947145164013, 0.016027672216296196, -0.012692220509052277, 0.001397324725985527, 0.013420475646853447, 0.012853302992880344, -0.009435991756618023, 0.006276886444538832, 0.006941898725926876, -0.0032281549647450447, 0.025937490165233612, -0.017241284251213074, 0.007768870331346989, -0.007347637787461281, 0.002538423053920269, -0.013184195384383202, -0.010358424857258797, -0.0021427180618047714, 0.01365829911082983, -0.01684625819325447, 0.0014983299188315868, 0.000351534690707922, 0.0063165174797177315, -0.018879029899835587, 0.005211321637034416, -0.020081104710698128, -0.016915133222937584, -0.003101029433310032, -0.01539674587547779, -0.020538456737995148, -0.011390119791030884, 0.0015364730497822165, 0.0005436073988676071, 0.03543772175908089, -0.0070318179205060005, -0.008582651615142822, 0.018136845901608467, 0.005800277926027775, -0.005618566647171974, 0.01218238566070795, -0.01158861443400383, 0.0021102712489664555, -0.023974966257810593, -0.013329906389117241, 0.0011253347620368004, 0.00362308113835752, 0.016789086163043976, -0.004461334552615881, 0.01412474736571312, 0.027812514454126358, 0.006038343533873558, -0.007726557087153196, -0.005378438159823418, 0.0030913962982594967, 0.07181981205940247, 0.003915394190698862, 0.010481077246367931, 0.0032002676744014025, 0.00127509911544621, 0.003752535441890359, -0.016854632645845413, -0.012075076811015606, -0.003992872778326273, -0.005638609640300274, -0.009202515706419945, -0.017083141952753067, -0.02323022298514843, 0.009450629353523254, 0.0009289162699133158, -0.015401095151901245, 0.001953382510691881, 0.03193099796772003, -0.03251596540212631, 0.03073911741375923, 0.010622881352901459, -0.0019202292896807194, -0.01900560036301613, -0.005055236630141735, 0.009806164540350437, -0.027237849310040474, -0.00657490361481905, 0.002366021741181612, 0.0019978261552751064, 0.002471774350851774, 0.014572402462363243, 0.00984221138060093, 0.00047970877494663, 0.013157736510038376, 0.017716852948069572, -0.003341002855449915, -0.0031593297608196735, 0.007958238944411278, -0.005416387692093849, 0.01770850270986557, 0.000718994066119194, -0.002052453812211752, -0.004505698569118977, -0.008096158504486084, 0.014858889393508434, -0.014365131966769695, -0.003963685594499111, -0.01051810197532177, -0.0009289231384173036, 0.008220670744776726, 0.04702503979206085, 0.0014907395234331489, 0.008551384322345257, -0.012479838915169239, 0.022667737677693367, 0.020288314670324326, -0.02306715026497841, 0.00993416178971529, -0.023378044366836548, 0.01027773879468441, 0.006008451338857412, -0.01927116885781288, -0.004349671304225922, -0.02072056755423546, 0.02684471383690834, 0.019782092422246933, 0.01267198659479618, -0.016362328082323074, 0.01776169054210186, 0.012532987631857395, 0.014084932394325733, 0.002525921678170562, 0.006917119026184082, -0.008332353085279465, 0.011039568111300468, 0.010153076611459255, 0.012001844123005867, 0.007911172695457935, 0.012291522696614265, 0.012875307351350784, -0.01125330664217472, -0.01536508183926344, -0.0023153384681791067, 0.005400208756327629, 0.024639111012220383, -0.01646217703819275, 0.002761341631412506, 0.014189696870744228, 0.004313046112656593, 0.00871913880109787, 0.04004732519388199, 0.010495660826563835, 0.001449595671147108, -0.001784579362720251, 0.011189376935362816, 0.03356631100177765, -0.009121055714786053, 0.005264218896627426, 0.0047279479913413525, 0.01225388515740633, 0.026003673672676086, -0.0023447643034160137, -0.0015183718642219901, -0.0030812607146799564, -0.003976134583353996, -0.008208573795855045, 0.007264883257448673, -0.010242601856589317, 0.015856439247727394, 0.016295194625854492, 0.009948824532330036, 0.016577042639255524, 0.012179868295788765, 0.02133975923061371, 0.0006154126022011042, 0.011740963906049728, -0.0006523352349177003, 0.02026372030377388, -0.003993763122707605, -0.015832317993044853, -0.010127871297299862, -0.015117641538381577, -0.00027513853274285793, 0.005979682318866253, -0.009249589405953884, -0.02365879900753498, -0.011286609806120396, 0.02699419856071472, -0.002667063847184181, 0.023500515148043633, 0.01797519624233246, 0.0107555091381073, 0.028250593692064285, 0.0400129109621048, -0.003466677851974964, -0.0106123648583889, -0.0005815307376906276, 0.030444052070379257, -0.01133657805621624, 0.012396231293678284, 0.004729067906737328, -0.003955804742872715, -0.010725090280175209, 0.00025161681696772575, 0.007651116698980331, -0.002966687548905611, -0.01692179962992668, 0.009109132923185825, 0.002932797186076641, -0.01176926214247942, 0.011443542316555977, 0.009825890883803368, -0.0274194423109293, -0.010570907965302467, 0.002499931724742055, 0.01453927718102932, -0.0017886634450405836, -0.013987530954182148, -0.026573695242404938, 0.015560166910290718, 0.01160220243036747, 0.002475135028362274, -0.0008030536118894815, -0.011855492368340492, 0.027344826608896255, 0.013961967080831528, -0.04335925728082657, 0.010037895292043686, -0.004054006189107895, -0.003351049032062292, -0.026475422084331512, 0.01203689444810152, -0.014044847339391708, 0.03128478676080704, -0.016364239156246185, -0.009746404364705086, -0.01840447634458542, -0.0003131004050374031, 0.011716471053659916, -0.044928766787052155, 0.014082534238696098, 0.007278627250343561, 0.004375401884317398, -0.0061097051948308945, 0.007408812176436186, -0.004511197563260794, -0.016828075051307678, -0.00077933503780514, 0.005369414575397968, 0.0043940371833741665, -0.027952279895544052, -0.00004936347249895334, -0.003999507986009121, 0.007796361111104488, 0.0036822250112891197, -0.014429468661546707, 0.0069782426580786705, -0.012813666835427284, 0.0115730632096529, 0.0007757211569696665, 0.03049216791987419, -0.021649891510605812 ]
[ 0.18348979949951172, 0.3864198923110962, 0.1395043432712555, 0.056724581867456436, 0.1854168027639389, -0.05069620907306671, 0.045697279274463654, -0.4200144112110138, -0.38330551981925964, -0.086065873503685, -0.23999711871147156, 0.05615565925836563, -0.1675490140914917, 0.532374918460846, -0.2772068679332733, 0.9161255955696106, 0.6806011199951172, 0.690639078617096, -0.14218544960021973, -0.8945791721343994, -0.613010823726654, -0.36030882596969604, 0.5225218534469604, -0.09733149409294128, 0.028391579166054726, 0.09428105503320694, 0.26786088943481445, -0.0026274730917066336, 0.20500893890857697, 0.07405588775873184, -0.04205704107880592, 0.681582510471344, 0.6519894003868103, -0.24420784413814545, 0.20278121531009674, 0.11686606705188751, -0.6837870478630066, -0.3635060787200928, 0.07015489041805267, -0.18583203852176666, -0.449027419090271, -0.5305429100990295, 0.10505257546901703, 0.7100549936294556, -0.3257034122943878, 0.21319478750228882, -1.040256381034851, 0.5575157403945923, -0.13523778319358826, 0.29699409008026123, 0.376474529504776, 0.1996709555387497, 0.6681439280509949, -0.06735099852085114, 0.37311896681785583, -0.028732595965266228, -1.0512012243270874, -0.1734858900308609, 0.39576345682144165, -0.6340377330780029, 0.04877902567386627, -0.22545398771762848, -0.33663874864578247, 0.26604706048965454, -0.08684416860342026, 0.6646512150764465, 0.09268862009048462, -0.22928617894649506, -0.4731833338737488, 0.2667885720729828, 0.4734151065349579, -0.1503589004278183, -0.2672138810157776, 0.13989229500293732, -0.42154136300086975, 0.09712875634431839, -0.4257031977176666, -0.13031475245952606, 0.3381769061088562, 0.02604505605995655, -0.04904625564813614, 0.162859708070755, 0.5561254024505615, 0.2246086746454239, 0.10068125277757645, -0.10667768865823746, -0.006530110724270344, 0.5324659943580627, -0.4494738280773163, 0.11558745801448822, -0.2596980333328247, 0.3537895381450653, 0.2616245448589325, 0.5127473473548889, -0.3515966236591339, 0.07457584887742996, 0.11917267739772797, -0.36313125491142273, 0.1115274429321289, 0.39225396513938904, -0.3127698600292206, -0.20678983628749847, -0.03859677538275719, -0.19402024149894714, -0.28126776218414307, -0.27990639209747314, -0.2434191107749939, -0.493967741727829, -0.4226352870464325, 0.3181931972503662, -1.2448675632476807, 0.26423022150993347, -0.1669992208480835, -0.39833322167396545, -0.18691879510879517, -0.3896883726119995, 0.03167392313480377, -0.17947076261043549, 0.03905134275555611, -0.27575159072875977, -0.2884906530380249, 0.9064993858337402, -0.07018747180700302, 0.471493124961853, 0.06372197717428207, -0.011697075329720974, 0.3313847482204437, -0.18161271512508392, -0.2542009949684143, 0.183990940451622, 0.49197083711624146, 0.8933038711547852, -0.21126475930213928, -0.21823103725910187, 0.04011791944503784, 0.02321252040565014, 0.31142616271972656, 0.26386457681655884, 0.4085131883621216, 0.052212905138731, -0.41050001978874207, -0.3919202387332916, -0.22976762056350708, 0.22139428555965424, 0.0059846495278179646, 0.08984088897705078, -0.2802017331123352, 0.1558680534362793, -0.10312174260616302, -0.20090292394161224, 0.14453886449337006, -0.048537950962781906, -0.6686745882034302, -0.5344988703727722, 0.04068564996123314, 0.3224996328353882, -0.30876341462135315, -0.5887089967727661, 0.11645476520061493, 0.17017391324043274, 0.06759955734014511, -0.09333747625350952, -0.2704067826271057, -0.3629949688911438, 0.519398033618927, -0.07377272099256516, -0.29187798500061035, 0.29696154594421387, -0.5845197439193726, 0.3455471694469452, -0.605155885219574, -0.3852056562900543, 0.19042496383190155, -0.9228436946868896, 0.20068511366844177, -0.22085736691951752, -0.11258681863546371, -0.2372736930847168, -0.11389056593179703, 0.2887256443500519, -0.7936910390853882, 0.2241264432668686, -0.17268507182598114, -0.5586530566215515, 0.07889875024557114, 0.2988762855529785, 0.6068868637084961, -0.06610201299190521, 0.5376603007316589, 0.1833689957857132, -0.3545391261577606, -0.4034195840358734, 0.5595706105232239, -0.2623220682144165, 1.4868083000183105, -0.21595004200935364, 0.1379004716873169, 0.5208592414855957, 0.2693495452404022, -0.07036032527685165, -0.34114789962768555, 0.20664645731449127, 0.8482540845870972, -0.24200165271759033, -0.8328774571418762, 0.01051090843975544, 0.07133930176496506, -0.3580436706542969, 0.2144850194454193, 0.18639273941516876, 0.48923248052597046, -0.371229350566864, -0.22368155419826508, -0.1352931261062622, 0.5394530892372131, -0.6157304644584656, 0.3616954982280731, -0.23389725387096405, -0.7223277688026428, -0.08647267520427704, 0.16976407170295715, -0.4522363841533661, 0.48608818650245667, 1.057023286819458, -0.4409979581832886, 0.9809308052062988, 0.3491778075695038, 0.38728997111320496, 0.6758078932762146, -0.12190225720405579, 0.34781789779663086, -0.08652760833501816, -0.3835175931453705, -0.3704899251461029, 0.4204074442386627, -0.0500824972987175, 0.24782347679138184, -0.27342090010643005, -0.2227439135313034, -0.29102760553359985, -0.04945679381489754, -0.013980650343000889, -0.23770420253276825, -0.056200966238975525, 0.09642580151557922, -0.7295530438423157, -0.30906057357788086, 0.10451073199510574, -1.1042628288269043, -0.2348332703113556, -0.0950692817568779, 0.7363085150718689, 0.34837856888771057, -0.4524967074394226, 0.06872453540563583, 0.038396790623664856, 0.3173879086971283, -0.38989415764808655, -0.23770321905612946, -0.5293863415718079, -0.18723386526107788, 0.46173498034477234, -0.09361744672060013, 0.006617010571062565, 0.10418287664651871, -0.4224112331867218, -0.44361934065818787, -0.12793318927288055, 1.1356253623962402, 0.5355916619300842, 0.32031914591789246, -0.05314476788043976, -0.8871837258338928, -0.2264530509710312, -0.39245954155921936, -0.5050686001777649, -0.05699832737445831, 0.5474924445152283, -0.11383401602506638, -0.44475099444389343, -0.07010684907436371, 0.2886699140071869, 0.8650161027908325, -0.46715402603149414, -0.17807020246982574, 0.5755720734596252, -0.6714485287666321, -0.07487601041793823, -0.2666986584663391, -0.7283703684806824, -0.1791778802871704, 0.3213854134082794, 0.10634186118841171, 0.04657603055238724, 0.12166707217693329, -0.3471944034099579, -0.10900168865919113, 0.589302122592926, 0.7191850543022156, -0.02093399316072464, -0.11992869526147842, 0.13077987730503082, 0.03236416354775429, -0.10777687281370163, -0.1391143500804901, -0.10484447330236435, 0.07573169469833374, 0.2958438992500305, -5.785618782043457, -0.20720608532428741, -0.4229052662849426, -0.043631117790937424, 0.10135581344366074, 0.022585658356547356, 0.9746196866035461, -0.1468430906534195, -0.11399614065885544, 0.1925123780965805, 0.04061054438352585, 0.3882778584957123, 0.10246273875236511, -0.24268296360969543, -0.5141286253929138, -0.5084758400917053, -0.3667825758457184, -0.006176488008350134, 0.549525797367096, 0.15550892055034637, 0.31839755177497864, 0.06958498060703278, -0.0756860077381134, 0.4222131371498108, -0.30752772092819214, -0.298484206199646, -0.7436826229095459, 0.017116889357566833, -0.7908099889755249, -0.7757502198219299, -0.33796948194503784, -0.13708904385566711, 0.0028067135717719793, 0.08491633832454681, 0.18764229118824005, 0.06625384092330933, -0.1475083976984024, 0.015078973956406116, -0.5249039530754089, -0.19581329822540283, 0.1719256341457367, -0.18369601666927338, 0.17054298520088196, -0.21000663936138153, 0.40889087319374084, 0.5100781321525574, 0.31845539808273315, -0.10947195440530777, -0.019080109894275665, 0.7325973510742188, 0.14805454015731812, -0.11798125505447388, 0.5073333382606506, 0.7913399934768677, 0.6191246509552002, -0.08795929700136185, -0.13903529942035675, -0.0742110162973404, 0.0443878099322319, 0.15583491325378418, 0.19508205354213715, 0.0817096158862114, -0.15373475849628448, -1.0146064758300781, -0.2526226341724396, 0.07169338315725327, -0.7621364593505859, -0.29036763310432434, 0.5304890871047974, -0.17320889234542847, -0.30766454339027405, 0.2600247859954834, 0.6881269216537476, -0.8439007997512817, 0.7730725407600403, -0.4965387284755707, 0.049841709434986115, 0.2659980356693268, 0.012265114113688469, 0.569415807723999, -0.11091628670692444, -0.2546883523464203, -0.08285872638225555, -0.2991773188114166, -0.028043249621987343, -0.6881791949272156, -0.5438127517700195, 0.08768442273139954, 0.22704701125621796, 0.6336872577667236, 0.31296664476394653, -0.12923426926136017, 0.17611412703990936, 0.24385085701942444, -0.026839496567845345, -0.06045442074537277, 0.12983456254005432, 0.9117757081985474, 0.4561978280544281, 0.4553191661834717, 0.5676565170288086, -0.024719199165701866, -0.7211983799934387, -0.45648983120918274, -0.2763238251209259, -0.2412257194519043, -0.2391258180141449, -0.03636195510625839, 0.6834447979927063, -0.5365360975265503, 0.483844518661499, -0.4328575134277344, -0.6317762136459351, -0.1705481857061386, 0.7040156126022339, 0.1447739452123642, 0.05685919150710106, -0.27897071838378906, 0.46003589034080505, -0.29283979535102844, 0.3955240547657013, 0.6850583553314209, -0.7068669199943542, 0.5542504787445068, 0.5902068018913269, -0.12440937757492065, 0.28666505217552185, 0.4412969946861267, -0.6428431272506714, 0.153070330619812, 0.2859528362751007, 0.2037741243839264, 0.08147026598453522, -0.31558313965797424, 0.19405782222747803, -0.08600636571645737, -0.5428574085235596, 0.705277681350708, 0.33574604988098145, -0.037012986838817596, 0.40908488631248474, -0.4433063566684723, -0.17037029564380646, 0.18633653223514557, 0.33517444133758545, 0.27571913599967957, 0.2828090786933899, 0.13792724907398224, -0.2667522430419922, 0.05800914019346237, -0.13332226872444153, -0.16969799995422363, 0.42288413643836975, 0.4054710566997528, -0.14871203899383545, -0.23856747150421143, 0.2731662392616272, 0.20912505686283112, -0.06851173937320709, -0.3858773410320282, 0.2633639872074127, 0.03770853206515312, -0.7110550999641418, -0.36372432112693787, -0.06711391359567642, -0.2882426083087921, -0.22744512557983398, -0.5132666230201721, 0.10449051111936569, 0.31179553270339966, -0.7056331038475037, -0.032545413821935654, -0.5835726857185364, -0.14340132474899292, 0.4803623855113983, -0.16973437368869781, 0.02425013668835163, 0.23693808913230896, 0.18368253111839294, 0.060243479907512665, -0.1774527132511139, -0.16308364272117615, -0.005106688477098942, -0.05245716869831085, 0.6983749866485596, 0.17422890663146973, -0.3204866349697113, -0.17715273797512054, 0.022503020241856575, -0.1627078652381897, 0.47564563155174255, 0.04049060493707657, -0.06001769006252289, 0.07148919999599457, 0.22056549787521362, 0.12117413431406021, 0.4231886863708496, 0.643280565738678, 0.22053782641887665, -0.16962802410125732, 0.42955270409584045, 0.7807387709617615, 0.036143384873867035, 0.1795140504837036, 0.9163011312484741, -0.19778262078762054, 0.054654255509376526, 0.31927329301834106, -0.6082645058631897, -0.33607450127601624, 0.11280883103609085, -0.8369499444961548, -0.05569414421916008, 0.12572309374809265, -0.17246699333190918, -0.0700477883219719, 0.3893895745277405, -0.6453601121902466, -0.3005634546279907, 0.27289435267448425, 0.4218827784061432, -0.020021360367536545, 0.09341008961200714, -0.19972673058509827, -0.8881989121437073, 0.23639249801635742, -0.14581257104873657, -0.3987501561641693, 0.3342702090740204, 0.07947047799825668, -0.2943001985549927, -0.1376829594373703, 0.38314589858055115, 0.17358559370040894, -0.14125004410743713, -0.5519685745239258, -0.3533167243003845, 0.24815073609352112, -0.1669067144393921, 0.34015628695487976, 0.08273666352033615, 0.6613425016403198, 0.09089037030935287, -0.25109344720840454, -0.24789075553417206, 0.6143620014190674, 0.3887958824634552, -0.24916864931583405, -0.22694426774978638, 0.4787153899669647, 0.8030655980110168, -0.5651485323905945, 0.21109898388385773, -0.007127529941499233, 0.7723978161811829, 0.40917372703552246, -0.38927462697029114, -0.7600342631340027, -0.3346332907676697, 0.455502986907959, -0.33657923340797424, -0.014013446867465973, -0.39816537499427795, 0.3469390869140625, 0.19399674236774445, 0.38608047366142273, -0.42785122990608215, -0.6171532273292542, 0.25466954708099365, -0.4137207865715027, 0.06334685534238815, 0.04662259668111801, 0.417598158121109, 0.7322499752044678, 0.24139872193336487, 0.8385036587715149, -0.6206693649291992, -0.5983234643936157, -0.15548017621040344, -0.3765422999858856, -0.04483502730727196, -0.17643296718597412, -0.06477297097444534, -0.12955187261104584, 0.40822046995162964, -0.39443260431289673, -0.2185438722372055, -0.7180448770523071, 0.07821652293205261, -0.05318639799952507, -0.42266514897346497, 0.3815065324306488, -0.2234945446252823, 0.3365231454372406, 0.2202361822128296, 0.19744640588760376, 0.3339138925075531, 0.356730192899704, 0.4343368113040924, -0.1980607509613037, -0.34757301211357117, 0.5606546998023987, 0.685028612613678, -0.22737626731395721, 0.11189562827348709, 0.34301868081092834, -0.005646937061101198, -0.0670190304517746, -0.22305485606193542, 0.30362147092819214, 0.29854756593704224, -0.08406905829906464, 0.2778252065181732, 0.14406412839889526, -0.35760098695755005, 0.14918093383312225, -0.24278588593006134, 0.0758945643901825, 0.3866892158985138, 0.022945674136281013, 0.5382680296897888, 0.8254983425140381, 0.5910832285881042, -0.025613579899072647, -0.21915753185749054, 0.3079732656478882, -0.012285721488296986, -0.022632401436567307, 0.29670730233192444, 0.8143446445465088, 0.19390058517456055, 0.2716576159000397, 0.07912611961364746, 0.6549420952796936, 0.20362134277820587, -0.1539873629808426, -0.4024879038333893, 0.2878403663635254, -0.059352029114961624, -0.09641436487436295, 0.755818784236908, -0.3387608230113983, -0.3505653440952301, 0.17809896171092987, 0.7000859975814819, 0.3754216134548187, 0.32529163360595703, -0.28591975569725037, -0.17274390161037445, 0.16614370048046112, 0.19597482681274414, -0.45026618242263794, -0.30723634362220764, -0.1790226399898529, -0.5933648347854614, 0.7042790651321411, 0.22570419311523438, -0.0807029977440834, -0.4465770423412323, 0.3898378312587738, -0.6428631544113159, -0.30069467425346375, -0.026291385293006897, 0.6353998184204102, 0.11307275295257568, -0.23193147778511047, 0.006790849845856428, -0.0011098725954070687, 0.05071388557553291, -0.6126046180725098, -0.42076265811920166, 0.013881487771868706, -0.36061200499534607, 0.015503855422139168, 0.5769765377044678, -0.3835206627845764, -0.044765811413526535, -0.16713160276412964, -0.017033182084560394, 0.3364439606666565, -0.6607382297515869, -0.04780606925487518, -0.29758086800575256, -0.5577939748764038, -0.17427869141101837, -0.08425067365169525, -0.41107168793678284, -0.09483963996171951, -0.4835377633571625, -0.169173002243042, 0.4629477858543396, -0.7511544227600098, 0.33484992384910583, 0.12753890454769135, -0.0988822877407074, -0.14549989998340607, 0.11534534394741058, -0.04343752935528755, 0.4315616488456726, 0.24871182441711426, -0.42681488394737244, 0.3554866909980774, -0.3053588569164276, 0.3215416371822357, -0.5265856981277466, 0.3863169252872467, -0.6018238067626953, -0.5454332828521729, -0.27890920639038086, 0.5071079134941101, 0.3309229612350464, 0.6708208322525024, -0.35092630982398987, 0.7555548548698425, 0.04363017901778221, 0.3034595847129822, 0.6806473135948181, -0.7683213949203491, -0.374325156211853, -0.5258962512016296, -0.15489163994789124, -0.35353684425354004, 0.6920620799064636, -0.03494088724255562, -0.08166186511516571, -0.14922025799751282, 0.467816025018692, 0.38650524616241455, -0.45218542218208313, 0.1712755411863327, -0.3940880000591278, 0.45446109771728516, -0.8037122488021851, 0.5598364472389221, -0.5754084587097168, 0.14583154022693634, -0.11761856079101562, 0.23359522223472595, -0.1406777948141098, 0.12094039469957352, -0.14104178547859192, -0.43119966983795166, 0.2954052984714508, -0.4246244430541992, -0.09238950163125992, 0.07113216072320938, -0.1732768416404724, -0.8876177668571472, -1.105102777481079, -0.2427053302526474, 0.33304569125175476, -0.6426811218261719, -0.21639101207256317, -0.08370445668697357, 0.29926198720932007, -0.510384202003479, -0.39523041248321533, -0.17503705620765686, 0.2841453552246094, 0.11236448585987091 ]
The focus of this article is planning for resiliency in the aftermath of a catastrophe. First, the authors offer their conception of planning for resiliency as a goal for recovering communities, and the benefits of planning in efforts to create more resilient places. Next, they discuss major issues associated with planning for postdisaster recovery, including barriers posed by federal and state governments to planning for resiliency, the promise and risks of compact urban form models for guiding rebuilding, and the failure to involve citizens in planning for disasters. Finally, they discuss lessons from prior research that address these issues and policy recommendations that foster predisaster recovery planning for resilient communities.
[ -0.0015842928551137447, 0.03395746275782585, 0.0016368913929909468, 0.02236057259142399, 0.02098166197538376, -0.022025223821401596, 0.009794101119041443, 0.020125169306993484, -0.011443530209362507, -0.0022581839002668858, -0.006527756340801716, 0.012700581923127174, -0.010266362689435482, 0.015625685453414917, 0.026878297328948975, 0.01377657800912857, 0.011644164100289345, 0.005110213533043861, 0.006417869124561548, -0.019552581012248993, -0.016504086554050446, -0.01440536417067051, 0.01090421061962843, 0.009745681658387184, -0.019279468804597855, -0.0129778441041708, 0.004634945187717676, -0.015201769769191742, -0.010886106640100479, -0.03920435160398483, 0.018265925347805023, 0.01212109811604023, 0.0031479904428124428, -0.0030715749599039555, 0.01620340161025524, 0.000855249585583806, -0.0031514069996774197, 0.01371279451996088, 0.004385056905448437, -0.0022752811200916767, 0.034947462379932404, -0.004742274060845375, 0.0047694663517177105, 0.021823104470968246, -0.006737837102264166, -0.005744806956499815, 0.001403886592015624, 0.023412803187966347, 0.007504284381866455, 0.0172658059746027, -0.008042958565056324, 0.00003914395347237587, -0.0038917362689971924, -0.0008200425654649734, -0.006265825126320124, -0.026240311563014984, 0.022069253027439117, 0.025405433028936386, -0.02060914784669876, -0.0002852487377822399, -0.006255321204662323, 0.029662657529115677, -0.023075858131051064, -0.00839918665587902, -0.003898915369063616, -0.06672368943691254, -0.03412909433245659, 0.022275717929005623, -0.005742210894823074, 0.034769486635923386, 0.005379755049943924, 0.008889785036444664, -0.012627894058823586, -0.00015784497372806072, 0.01075040828436613, -0.007853304035961628, 0.0028012841939926147, 0.0274333693087101, -0.01097252406179905, 0.04093357175588608, 0.000944734551012516, -0.011965584009885788, -0.001791156828403473, 0.023245256394147873, 0.011776747182011604, 0.010065222159028053, 0.00964630302041769, -0.0037929178215563297, -0.0032218785490840673, -0.01176364440470934, 0.03190774470567703, -0.005948032718151808, -0.017750807106494904, 0.007875548675656319, -0.040578942745923996, -0.009002018719911575, -0.001576532144099474, 0.017135990783572197, -0.021682795137166977, -0.010444525629281998, -0.0066346521489322186, 0.021160727366805077, 0.01578080840408802, 0.016976572573184967, 0.01634291000664234, 0.0005656464491039515, -0.025453675538301468, 0.014712889678776264, -0.005432062782347202, 0.0027295993641018867, 0.018415387719869614, 0.0028163311071693897, 0.0027243695221841335, -0.02287212386727333, -0.03462940827012062, 0.005928332451730967, -0.010845337063074112, 0.0142169538885355, 0.009123429656028748, -0.00348912226036191, 0.010497916489839554, 0.01033277902752161, -0.009964896366000175, 0.03009216859936714, 0.0036289659328758717, 0.011238910257816315, 0.005985247902572155, 0.0013208375312387943, -0.03286134824156761, 0.0026282561011612415, -0.010379014536738396, 0.005018995143473148, 0.01880483701825142, 0.0026133584324270487, 0.022512750700116158, 0.004732760135084391, -0.0006447751075029373, -0.016767283901572227, 0.00291271205060184, 0.010969305410981178, 0.011029347777366638, 0.013016736134886742, -0.011132074519991875, 0.012735113501548767, 0.014390782453119755, -0.007787179667502642, -0.008655406534671783, 0.01996370404958725, 0.001999643864110112, -0.010436765849590302, 0.020386844873428345, -0.002894734963774681, -0.0004072095616720617, -0.010653853416442871, -0.005959896370768547, -0.0058965482749044895, -0.004294328857213259, -0.0053985267877578735, -0.008760569617152214, -0.009173701517283916, 0.008234493434429169, 0.0025793472304940224, -0.008128450252115726, 0.008021432906389236, 0.03794108331203461, 0.023606933653354645, 0.004396015778183937, 0.0033172478433698416, -0.0079349335283041, 0.001570938853546977, -0.008844700641930103, -0.008567236363887787, -0.015168657526373863, 0.007236788049340248, 0.013579955324530602, -0.01114737894386053, 0.00672586215659976, 0.007214331533759832, 0.0076755923219025135, 0.06678513437509537, 0.029267368838191032, 0.0011296385200694203, -0.022827565670013428, -0.00775666069239378, 0.004767749458551407, -0.015026486478745937, 0.043192051351070404, -0.008562015369534492, -0.011168180964887142, -0.0031055996660143137, -0.009571392089128494, -0.025005394592881203, -0.02460750937461853, 0.01606135629117489, -0.001259703654795885, 0.0046442365273833275, -0.0023848791606724262, 0.000457526883110404, 0.00336915859952569, 0.006876752711832523, 0.02766459248960018, -0.006634212564677, 0.04522904381155968, -0.0028871577233076096, 0.0027036587707698345, -0.0005697414744645357, -0.0021862289868295193, -0.01167078036814928, 0.00003305496647953987, 0.004650602117180824, 0.015448475256562233, -0.04045305401086807, -0.016494404524564743, 0.013175725005567074, 0.017599845305085182, 0.00016783457249403, 0.011818554252386093, -0.025450021028518677, 0.012024808675050735, -0.014311064966022968, -0.005310265347361565, 0.002923104912042618, -0.009661107324063778, -0.02504374086856842, -0.0032682903110980988, 0.00420618150383234, -0.0037919660098850727, 0.014489040710031986, -0.002823594491928816, 0.0008230339735746384, 0.008852360770106316, -0.01514505036175251, -0.006928387098014355, -0.0353575199842453, 0.0075452011078596115, 0.04343829303979874, 0.010008788667619228, -0.015776339918375015, 0.019985372200608253, -0.010437194257974625, -0.008511355146765709, 0.018117036670446396, 0.007319782394915819, -0.012609806843101978, -0.0019844812341034412, -0.022722145542502403, -0.005565655883401632, 0.0055150678381323814, 0.00029780645854771137, 0.0019465559162199497, 0.0024856282398104668, 0.01505025289952755, -0.006369454320520163, 0.003390759229660034, 0.020000766962766647, -0.018696367740631104, 0.039246343076229095, 0.012346949428319931, 0.02431371435523033, -0.005679043009877205, 0.011235212907195091, 0.006344638764858246, -0.00759432278573513, -0.012720492668449879, -0.00039100321009755135, 0.0007554870098829269, 0.02863903157413006, -0.007760205306112766, -0.004493546672165394, 0.021687744185328484, -0.000709484564140439, -0.012037992477416992, -0.0006088486406952143, -0.08173488080501556, -0.014280211180448532, 0.020664110779762268, 0.004249903839081526, 0.02106494829058647, -0.04366869479417801, 0.014589346945285797, -0.009327455423772335, -0.024476824328303337, 0.03401987999677658, -0.004512418992817402, 0.021097278222441673, -0.012911311350762844, 0.010308150202035904, 0.00005131680518388748, -0.015771742910146713, 0.0014989038463681936, 0.014185430482029915, -0.021006740629673004, 0.01447596587240696, -0.003535970114171505, -0.006199522875249386, 0.005069701932370663, -0.006550619378685951, -0.027650073170661926, 0.013715717010200024, -0.0019739342387765646, -0.016517216339707375, -0.013225458562374115, 0.018137656152248383, 0.017620351165533066, 0.0035898308269679546, 0.003242839826270938, -0.015200482681393623, -0.007502526044845581, 0.01674036495387554, -0.005968750454485416, -0.029975466430187225, -0.012038066983222961, -0.0167181845754385, 0.04414923116564751, 0.02376706153154373, -0.008097573183476925, -0.010487976484000683, 0.007308910135179758, 0.017915701493620872, 0.025167454034090042, 0.020398568361997604, 0.0018629363039508462, 0.01208352018147707, -0.007706846110522747, -0.009853153489530087, -0.013720846734941006, 0.008037848398089409, -0.009616031311452389, -0.019864346832036972, -0.021919146180152893, -0.005066663958132267, -0.014049207791686058, -0.0038838875479996204, -0.026353109627962112, 0.018829964101314545, -0.005019254516810179, 0.051935918629169464, -0.0039019703399389982, -0.023084592074155807, 0.012424740009009838, 0.009331006556749344, 0.00410870648920536, -0.010369453579187393, 0.020642850548028946, -0.010051624849438667, -0.005026188679039478, -0.0008004677947610617, 0.00573997525498271, -0.010564815253019333, -0.01833963394165039, 0.0006797867827117443, 0.0059588272124528885, 0.016130950301885605, -0.004278378561139107, 0.00025640567764639854, -0.01764393225312233, -0.01573985442519188, -0.017388267442584038, 0.019286813214421272, 0.00796772725880146, 0.018603947013616562, 0.004309533163905144, -0.015437133610248566, -0.014927464537322521, -0.0013153217732906342, -0.03228866308927536, -0.0014501987025141716, 0.018412070348858833, -0.030452188104391098, -0.011028368957340717, -0.020594848319888115, 0.011371403932571411, 0.011350469663739204, -0.008779274299740791, 0.010483667254447937, 0.013719671405851841, -0.0216241292655468, -0.0043761469423770905, 0.007825706154108047, 0.009106384590268135, 0.008018674328923225, -0.01511185523122549, -0.01674908958375454, 0.0077928099781274796, -0.018685949966311455, 0.0007191996555775404, 0.021179601550102234, 0.01617300510406494, 0.018755314871668816, 0.0011732308194041252, -0.003966093063354492, 0.07210059463977814, -0.01384713500738144, 0.01797015406191349, -0.00010605971328914165, -0.002182932570576668, -0.014684026129543781, 0.019184252247214317, 0.0035510787274688482, 0.01075779553502798, -0.003827407956123352, 0.012766357511281967, 0.008076794445514679, 0.023849613964557648, 0.00647774338722229, 0.005923503078520298, 0.018670881167054176, -0.007442783564329147, 0.014656811021268368, -0.029195215553045273, -0.011938723735511303, -0.006053818855434656, -0.02114301174879074, -0.00413550715893507, 0.01593218930065632, -0.006493559572845697, -0.004464282188564539, 0.01238043699413538, -0.00944859255105257, 0.014661690220236778, 0.0018429388292133808, -0.0221363864839077, 0.022843502461910248, -0.0009531790856271982, -0.01488225907087326, 0.006536333821713924, 0.004103024024516344, 0.021649764850735664, -0.01054310891777277, 0.0041750287637114525, 0.017480505630373955, -0.022899964824318886, -0.015473300591111183, 0.02043970301747322, 0.013879682868719101, -0.011454178020358086, 0.016325293108820915, 0.012620793655514717, -0.006905393674969673, -0.00448601646348834, 0.020833883434534073, -0.02289561554789543, 0.0024129506200551987, 0.00739591708406806, 0.0037005345802754164, -0.006105889566242695, -0.02399580366909504, 0.012206533923745155, -0.016300000250339508, 0.0025146629195660353, -0.032144077122211456, -0.023078477010130882, -0.013495264574885368, 0.004516500048339367, -0.012840909883379936, -0.002320859581232071, -0.01641882210969925, 0.029525483027100563, -0.02425672672688961, 0.022663798183202744, 0.012121003121137619, 0.008004378527402878, -0.00634828582406044, -0.013734428212046623, 0.0036509865894913673, 0.012511230073869228, -0.0016979119973257184, -0.0012603418435901403, -0.0021215956658124924, 0.020212674513459206, 0.002295195125043392, -0.0309576578438282, 0.008760642260313034, 0.001955095212906599, -0.00009415065869688988, 0.014802568592131138, 0.02676069550216198, 0.00823221541941166, -0.07417280972003937, 0.01624351367354393, 0.01926605962216854, -0.010699795559048653, -0.018113531172275543, 0.014243509620428085, -0.003237796714529395, -0.02144928276538849, -0.014161567203700542, -0.006108831614255905, -0.031126413494348526, -0.00500165019184351, -0.02103492058813572, -0.0023520595859736204, 0.013951277360320091, -0.019429467618465424, -0.0051729558035731316, -0.00028444192139431834, -0.015412665903568268, 0.020683621987700462, 0.029926057904958725, -0.004363557789474726, 0.0033040218986570835, 0.009320961311459541, 0.005657692905515432, -0.08086363971233368, -0.019853435456752777, 0.0011768420226871967, -0.0056334794498980045, 0.01314516831189394, -0.006795255932956934, -0.02111731842160225, -0.019610613584518433, 0.031742338091135025, -0.014560626819729805, -0.010849189013242722, -0.005360657349228859, -0.025764089077711105, -0.015273235738277435, 0.009280620142817497, -0.007308135274797678, -0.006086642853915691, 0.004061983898282051, 0.004073158837854862, -0.008830271661281586, 0.01721941865980625, 0.005679486319422722, -0.012554183602333069, -0.011230511590838432, -0.012360300868749619, 0.0014191814698278904, -0.003467756323516369, 0.009028766304254532, 0.006901872809976339, 0.001048270147293806, 0.01051175594329834, 0.025972185656428337, -0.019897684454917908, -0.000010299263522028923, 0.033613912761211395, -0.010450506582856178, 0.01979791559278965, -0.006277932785451412, 0.003464160719886422, 0.00013667281018570065, -0.0077279480174183846, 0.02507123351097107, 0.02402549609541893, 0.02506774291396141, -0.014012412168085575, 0.028964467346668243, 0.0077161649242043495, 0.0016968431882560253, 0.020452195778489113, 0.003829827532172203, 0.015532857738435268, -0.013416239991784096, 0.01596141792833805, -0.011090941727161407, -0.010683497413992882, 0.011060578748583794, -0.01014493778347969, -0.0013234498910605907, 0.04721926152706146, 0.002436589915305376, 0.017688170075416565, -0.010400598868727684, -0.039311401546001434, 0.07183080911636353, -0.032564617693424225, -0.004007183015346527, 0.003987901844084263, -0.021803323179483414, -0.007615331094712019, 0.012699552811682224, -0.007473341654986143, 0.004528474062681198, -0.021455902606248856, 0.024213247001171112, -0.004368710331618786, -0.02610752172768116, 0.007149999495595694, 0.030706163495779037, -0.019314391538500786, 0.00496285455301404, -0.013505707494914532, -0.006317873019725084, -0.004713083151727915, 0.008796585723757744, 0.022716937586665154, -0.0005673252744600177, 0.021867038682103157, 0.02734982594847679, -0.01128365471959114, 0.017087846994400024, 0.022612392902374268, -0.02003762684762478, -0.02249895967543125, -0.039656106382608414, 0.022664250805974007, -0.0046877171844244, -0.005613632034510374, 0.01555787306278944, -0.041472427546978, 0.01437905989587307, -0.00537126325070858, -0.011879178695380688, 0.015433921478688717, -0.00819101557135582, 0.009134851396083832, 0.013567459769546986, -0.033438317477703094, -0.0020177015103399754, -0.014066819101572037, 0.029280105605721474, -0.05459755286574364, -0.0004664268344640732, 0.005950041115283966, 0.015196844935417175, -0.003842256497591734, 0.00393070001155138, 0.016366804018616676, -0.013615783303976059, -0.020428240299224854, -0.03271136060357094, 0.011619281023740768, 0.022957883775234222, -0.011312329210340977, -0.017967745661735535, -0.01718444749712944, 0.004332159645855427, -0.006691818591207266, 0.02568846382200718, -0.0035113240592181683, -0.02058319002389908, -0.012870745733380318, 0.0014110878109931946, 0.014800244010984898, 0.012447776272892952, 0.010750014334917068, 0.004304189700633287, 0.0024915249086916447, 0.003059323877096176, -0.022218652069568634, 0.003453015349805355, 0.013748970814049244, -0.007368468679487705, -0.01152891293168068, -0.005992608144879341, 0.015579120256006718, 0.02173183485865593, -0.014887452125549316, 0.009248381480574608, 0.004262857139110565, 0.02277107909321785, 0.019940927624702454, -0.016132047399878502, 0.006996333599090576, 0.0031051128171384335, 0.012567771598696709, 0.0018487046472728252, -0.00954076275229454, 0.0040270304307341576, 0.03509131819009781, 0.00569923734292388, 0.008290428668260574, 0.004707577638328075, 0.012070588767528534, 0.01979568600654602, 0.006154616363346577, 0.006623007357120514, -0.008459897711873055, 0.00023488409351557493, -0.0022112135775387287, 0.01665402390062809, 0.002157431561499834, 0.019331565126776695, -0.014331179670989513, 0.012851672247052193, 0.00988511461764574, -0.003475392935797572, 0.002604944398626685, -0.001571661327034235, 0.01680019497871399, -0.035443879663944244, 0.02706895023584366, -0.012758267112076283, -0.011032335460186005, -0.04382169246673584, -0.00753435492515564, 0.007548612542450428, -0.0042731440626084805, -0.00406558346003294, 0.0006851041689515114, -0.008732559159398079, -0.00489959679543972, 0.016924891620874405, 0.003772119525820017, -0.007488188799470663, 0.008643475361168385, -0.0158357135951519, -0.021229878067970276, -0.012862512841820717, 0.004208452068269253, -0.011027508415281773, 0.008982032537460327, -0.01713760569691658, -0.017826102674007416, -0.01630380004644394, 0.003723993431776762, 0.0009469002252444625, -0.009681226685643196, 0.009388100355863571, -0.003361229784786701, 0.007234914693981409, 0.008462958969175816, 0.0285028126090765, -0.014218372292816639, -0.003328976221382618, 0.0028538068290799856, 0.03451705724000931, -0.007610626053065062, 0.004235848318785429, 0.037318155169487, 0.008452221751213074, 0.01585293374955654, -0.02321470156311989, -0.0017903400585055351, -0.010961449705064297, -0.0328320637345314, -0.03086254373192787, -0.01439598761498928, 0.0036132154054939747, 0.0049756355583667755, 0.023632124066352844, -0.011148170568048954, 0.005417623557150364, -0.000037391320802271366, 0.0004886528477072716, 0.026949618011713028, -0.01988990604877472, 0.012343119829893112, -0.015080668963491917, -0.015965471044182777, 0.0012754283379763365, 0.009948786348104477, -0.010423839092254639, -0.012934280559420586, 0.01714102178812027, 0.030719805508852005, -0.010969297960400581, -0.013435028493404388, -0.01112965028733015, 0.00571855204179883, -0.0045470609329640865, 0.014981675893068314, 0.0029765544459223747, -0.002695270348340273, 0.025741158053278923, 0.01639021374285221, -0.01698377914726734, -0.019653961062431335, -0.006595171056687832, -0.007778522092849016, -0.009061893448233604, -0.0012808586470782757, 0.001283683581277728, 0.008581509813666344, 0.024883758276700974, -0.02419605478644371 ]
[ 0.26350679993629456, -0.04413607716560364, -0.14930002391338348, 0.017304571345448494, -0.14837856590747833, 0.20332537591457367, 0.43111175298690796, -0.36939868330955505, -0.05620114132761955, -0.5021311640739441, -0.29206663370132446, 0.3844839036464691, 0.14520195126533508, 0.25347164273262024, -0.14408014714717865, 0.6790177226066589, 0.36273911595344543, 0.1550443321466446, -0.14885014295578003, -0.23484106361865997, -0.3062063753604889, -0.14258244633674622, -0.1071803942322731, 0.17179033160209656, 0.27278539538383484, 0.0037823549937456846, 0.5229356288909912, 0.20206330716609955, -0.01835797354578972, -0.14988423883914948, -0.19251519441604614, 0.42417290806770325, -0.5738791227340698, -0.43981266021728516, -0.1972799003124237, 0.11874492466449738, -0.08462934195995331, -0.17032861709594727, -0.10593873262405396, -0.5449233055114746, 0.4043090045452118, -0.12245143949985504, -0.10881203413009644, 0.18126122653484344, -0.2779846489429474, -0.4424690008163452, -1.301039218902588, -0.08947379142045975, -0.601823627948761, -0.5030589699745178, -0.038882046937942505, 0.4310765564441681, 0.24144800007343292, -0.02733525261282921, -0.19146372377872467, 0.3464197516441345, -0.5134205222129822, -0.4057539999485016, 0.4084700345993042, -0.598569929599762, -0.30979689955711365, -0.11193713545799255, -0.09895937889814377, 0.08173083513975143, -0.3166022300720215, 0.41934680938720703, 0.021687950938940048, 0.3257192075252533, 0.169659823179245, -0.5149756669998169, -0.027524074539542198, -0.11251077800989151, 0.012030289508402348, 0.471729576587677, -0.23941539227962494, 0.25767946243286133, 0.3355777859687805, -0.29657578468322754, -0.22465938329696655, 0.08370408415794373, 0.005576028022915125, -0.0614851713180542, 0.10993766784667969, -0.6003291010856628, 0.7126412391662598, -0.2187560349702835, 0.13626354932785034, 0.3933221101760864, -0.6463282704353333, 0.5945954918861389, -0.01101625431329012, -0.2438860386610031, 0.4182536005973816, 0.7075257301330566, 0.5779678225517273, -0.013170577585697174, 0.34158071875572205, 0.12669606506824493, -0.28142452239990234, 0.3938528299331665, -0.03930458799004555, 0.03618825227022171, -0.06440648436546326, -0.0024446737952530384, -0.0869058296084404, -0.5283734202384949, -0.2788882851600647, -0.5557194352149963, -0.4118078947067261, 0.009451748803257942, -0.415115088224411, 0.4603416621685028, 0.09231508523225784, -0.14995747804641724, 0.061710890382528305, -0.07972006499767303, 0.22697338461875916, -0.04174651950597763, -0.6422696709632874, 0.2634161710739136, 0.02899945341050625, 0.9588244557380676, -0.1479082554578781, 0.08250720053911209, -0.008034013211727142, 0.08210032433271408, 0.658254086971283, 0.2903895378112793, -0.7131093144416809, 0.3140932321548462, 0.23200367391109467, 0.3410203158855438, -0.6904765963554382, -0.04078728333115578, -0.2627803385257721, -0.20951536297798157, -0.38703447580337524, 0.3691366910934448, 0.21114656329154968, 0.002490335376933217, -0.13754776120185852, -0.4311167001724243, 0.1753048449754715, -0.09017238020896912, 0.23005051910877228, -0.36847513914108276, -0.21840952336788177, 0.03162025287747383, -0.12004555761814117, 0.1277400404214859, 0.3510124385356903, 0.39067327976226807, -0.7946217656135559, 0.3453161120414734, 0.01838783174753189, 0.7924651503562927, 0.3560818135738373, -0.13858476281166077, 0.14529703557491302, 0.3480566143989563, 0.21546372771263123, 0.2667235732078552, 0.04436200484633446, -0.21226710081100464, 0.22918979823589325, -0.22219642996788025, 0.14598597586154938, 0.14597421884536743, 0.2273983359336853, 0.052031565457582474, -0.44595006108283997, 0.3245258033275604, -0.06910494714975357, -0.30558687448501587, 0.296336829662323, 0.15407522022724152, 0.70034259557724, 0.46650147438049316, -0.06712235510349274, 0.17405758798122406, -0.6282657384872437, -0.10182276368141174, 0.08556732535362244, -1.0270006656646729, -0.014291890896856785, -0.1327664852142334, 0.15552058815956116, 0.022312743589282036, 0.12097059935331345, 0.09100554138422012, -0.5324347019195557, -0.3787326514720917, 0.4591176211833954, -1.0736531019210815, 0.9436784982681274, -0.330427348613739, -0.04353782534599304, 1.2116841077804565, -0.12559546530246735, 0.06702244281768799, 0.26037687063217163, -0.22459660470485687, 0.29568126797676086, 0.3642689287662506, -0.31583863496780396, 0.07869178801774979, 0.20666562020778656, 0.36068516969680786, -0.2993656098842621, -0.05942169576883316, 0.9844959378242493, 0.1566007435321808, -0.3140178620815277, -0.20150871574878693, 0.1493065059185028, -0.37094932794570923, 0.04961547255516052, 0.44738829135894775, -0.20735524594783783, -0.13959082961082458, 0.8780552744865417, -0.39333418011665344, 0.2948930561542511, 0.39715948700904846, 0.15962544083595276, 0.045527100563049316, 0.3931487500667572, 0.10528623312711716, 0.7341396808624268, -0.533455491065979, 0.058678433299064636, 0.580262303352356, -0.07549462467432022, -0.9296687841415405, -0.19024020433425903, -0.147014319896698, -0.24225153028964996, 0.40645021200180054, -0.19512462615966797, -0.25358593463897705, -0.12363255769014359, 0.0369068942964077, -0.3737328350543976, 0.5069000124931335, -0.05649378150701523, -0.28071779012680054, -0.28734904527664185, 0.29682257771492004, -0.8410763144493103, 0.24925416707992554, 0.03704197704792023, 0.6356519460678101, 0.5253331065177917, -0.23758374154567719, 0.50103360414505, 0.1467968374490738, -0.11877921968698502, -0.19828912615776062, 0.19598421454429626, -0.174543097615242, 0.11708191782236099, 0.21491463482379913, -0.04072041064500809, 0.07275842130184174, 0.32857897877693176, -0.3642911911010742, -0.44799843430519104, -0.5834349989891052, 0.11393123865127563, 1.0262434482574463, 0.4480448365211487, -0.07601067423820496, -0.26329928636550903, 0.3479568660259247, -0.2499685436487198, -0.8055856227874756, 0.31500864028930664, 0.5276778340339661, -0.47823622822761536, -0.5974958539009094, -0.10827784240245819, 0.9197783470153809, 0.47083780169487, -0.6730358600616455, -0.1967622935771942, -0.23205721378326416, 0.39793944358825684, 0.1985274702310562, -0.911954939365387, 0.3070515990257263, -0.1991245150566101, -0.4267365038394928, 0.08349233865737915, -0.4049820005893707, 0.3094962537288666, 0.6465187072753906, -0.4464757442474365, 0.23412419855594635, 0.04227089509367943, -0.0346967875957489, -0.48804664611816406, -0.007953180931508541, 0.13519807159900665, 0.07461925595998764, 0.12576818466186523, -0.11796949803829193, -0.4837096631526947, 0.5101396441459656, -6.07393741607666, -0.33617353439331055, -0.2503805160522461, -0.359920471906662, -0.2028925120830536, 0.20569676160812378, 0.7329924702644348, -0.14352045953273773, 0.40703684091567993, -0.41437506675720215, 0.338858038187027, 0.20391567051410675, 0.05588338524103165, 0.4776354432106018, 0.2436177134513855, -0.06330916285514832, 0.47655126452445984, 0.7300594449043274, -0.0400887168943882, 0.21355345845222473, 0.49939948320388794, -0.5471828579902649, -0.12525799870491028, 0.7048423290252686, 0.188773512840271, -0.10725776106119156, -0.8350129723548889, 0.5105434060096741, -0.08374597132205963, 0.30648520588874817, 0.7699586749076843, -0.14806096255779266, -0.10300596058368683, -0.20220929384231567, 0.2853595018386841, 0.5533477067947388, 0.026366734877228737, 0.30829334259033203, -0.30677711963653564, -0.4342409074306488, 0.033250097185373306, 0.10751371085643768, -0.43996015191078186, -0.11090347915887833, 0.23431943356990814, -0.24033045768737793, 0.08393771201372147, 0.393921434879303, -0.3053908348083496, 0.9228606820106506, 0.22680442035198212, -0.053471509367227554, 0.44213470816612244, 0.6606423854827881, 0.13457083702087402, -0.37018075585365295, 0.24792057275772095, 0.03117441199719906, -0.16486592590808868, 0.3206838369369507, 0.3268679678440094, -0.1905001550912857, 0.3300343453884125, -0.5206660032272339, -0.19142866134643555, 0.013190384022891521, -1.075682520866394, -0.2970682978630066, -0.21946319937705994, -0.25417470932006836, -0.5341309905052185, -0.04687049984931946, -0.011096428148448467, -0.7808892726898193, 0.2948911190032959, -0.7489545941352844, 0.21603992581367493, -0.2603417932987213, 0.26495546102523804, -0.2607071101665497, -0.3783641755580902, -0.18096618354320526, 0.1296267807483673, 0.08151562511920929, 0.13093042373657227, 0.1417313814163208, 0.12435132265090942, 0.14263910055160522, -0.44666358828544617, -0.17750677466392517, 0.3249407410621643, -0.4787422716617584, 0.19130513072013855, 0.0750431939959526, 0.35523876547813416, 0.9260664582252502, 0.2644840180873871, -0.14982779324054718, 0.5267848968505859, -0.4560277462005615, -0.02988702431321144, 0.010626138187944889, 0.06490325182676315, -0.39788708090782166, 0.36416754126548767, -0.3376568853855133, -0.10146825760602951, 0.21757231652736664, 0.7935665249824524, -0.4538733661174774, 0.3206130862236023, 0.27732113003730774, -0.2625608742237091, -0.5918698310852051, 0.43045759201049805, -0.07517889887094498, -0.07806993275880814, 0.19461418688297272, 0.46126604080200195, 0.05099545046687126, 0.3353029489517212, -0.08041558414697647, -0.22445157170295715, 0.40009909868240356, 0.11398537456989288, -0.2630460560321808, -0.32462501525878906, 0.28578981757164, -0.5303627848625183, 0.31639572978019714, 0.23487979173660278, 0.3672879636287689, -0.3837715983390808, 0.35411474108695984, 0.39557597041130066, -0.5355645418167114, 0.16626083850860596, -0.0977654829621315, -0.1389227956533432, -0.3323340117931366, 0.14549246430397034, 0.11024076491594315, -0.4964349567890167, -0.18423399329185486, -0.07114601880311966, 0.20611216127872467, -0.14440663158893585, 0.057493675500154495, -0.4219602346420288, 0.3593589663505554, -0.13562628626823425, 0.5478243231773376, -0.213637575507164, -0.4940706789493561, -0.32935741543769836, 0.17186793684959412, 0.4735356271266937, 0.14755132794380188, 0.2859692871570587, -0.2705399692058563, 0.3186902701854706, 0.132196843624115, -0.9841501712799072, -0.29225295782089233, 0.26915618777275085, -0.17538556456565857, -0.7976605892181396, -0.37803885340690613, -0.08404787629842758, 0.4292193651199341, -0.06922707706689835, -0.08523841202259064, -0.5918895602226257, -0.3624820113182068, 0.1925623118877411, -0.4961916208267212, -0.03299447521567345, 0.04582730680704117, -0.3137045204639435, -0.4529050886631012, -0.04533138498663902, -0.6454265117645264, -0.3014805018901825, -0.21918416023254395, 0.5516204237937927, 0.1819777935743332, -0.17233602702617645, -0.2680279612541199, -0.6669284105300903, -0.683164656162262, -0.06357613205909729, 0.2780987024307251, 0.3940877616405487, 0.22476980090141296, 0.12543924152851105, -0.2167971432209015, 0.08667074143886566, 0.23144839704036713, -0.06446555256843567, -0.15124362707138062, -0.04009603336453438, 0.025437556207180023, -0.7421445250511169, 0.261654257774353, 0.15144288539886475, -0.6349305510520935, 0.42161446809768677, -0.2565094232559204, -0.19038568437099457, -0.08550053834915161, -0.3891872763633728, -0.113791823387146, -0.0479014553129673, 0.04903537407517433, -0.33527037501335144, -0.17908351123332977, 0.1854396015405655, -0.6955128908157349, -0.38362032175064087, 0.26930877566337585, 0.2305767685174942, -0.08117745071649551, -0.15822483599185944, -0.1367196887731552, -0.3675934970378876, -0.0009685465483926237, 0.19518983364105225, -0.5815858244895935, -0.20819783210754395, 0.09984005987644196, -0.2978719174861908, -0.10685265064239502, 0.2564980387687683, 0.06289702653884888, -0.4550710618495941, -0.2682492733001709, -0.3233373761177063, 0.09415051341056824, -0.1316763162612915, 0.4019683301448822, -0.06947735697031021, 0.4422321617603302, 0.6491007208824158, -0.5993273258209229, -0.07356081157922745, -0.14822624623775482, 0.3933832049369812, -0.12556950747966766, -0.547528088092804, 0.01665223017334938, 0.22446464002132416, -0.1998637467622757, -0.443161278963089, -0.12205931544303894, 0.32721301913261414, -0.18093401193618774, -0.5432451963424683, -0.42598864436149597, 0.15850792825222015, 0.29364198446273804, 0.36751583218574524, -0.35493892431259155, -0.4412025213241577, -0.07380437850952148, 0.7120038270950317, -0.10855050384998322, 0.012821700423955917, -0.6811374425888062, -0.10651057213544846, -0.590130627155304, -0.20848730206489563, 0.2468000203371048, 0.3550889492034912, 0.19143401086330414, 0.3936445415019989, 0.13153991103172302, 0.19096125662326813, -0.08603944629430771, -0.028756817802786827, 0.057108134031295776, -0.1343807578086853, -0.07130855321884155, -0.49478286504745483, -0.1984008103609085, 0.11757081747055054, -0.3914538621902466, 0.18628402054309845, 0.10783129185438156, -0.1828378438949585, -0.3163434565067291, -0.47095921635627747, 0.1679266095161438, -1.1045836210250854, -0.1273060142993927, 0.09461992979049683, 0.4014856815338135, 0.39286690950393677, 0.0334332175552845, 0.014753592200577259, -0.09269632399082184, -0.12060251832008362, 1.0852938890457153, -0.23632706701755524, -0.5361469984054565, 0.3423230051994324, 0.16333165764808655, 0.08500327169895172, 0.21683381497859955, 0.13025280833244324, 0.29138854146003723, 0.14905492961406708, -0.06355702877044678, 0.32960593700408936, 1.049225091934204, -0.07286480069160461, 0.3142729699611664, 0.08731701225042343, -0.4924006164073944, 0.7717763185501099, 0.17975248396396637, -0.04726025462150574, 0.34767410159111023, 0.6550697684288025, -0.30075550079345703, -0.34374523162841797, 0.6681755781173706, -0.34437039494514465, -0.020549168810248375, 0.3047833740711212, 0.41642260551452637, 0.3678654134273529, 1.0962930917739868, -0.29758843779563904, 0.0725291445851326, 0.06919871270656586, 0.5364722609519958, 0.4245643615722656, -0.5265175104141235, -0.22569116950035095, -0.06248719245195389, 0.6043075919151306, 0.13093695044517517, 0.15157410502433777, 0.29783040285110474, -0.3337234854698181, 0.06209656223654747, 0.13814173638820648, 0.6223301291465759, -0.578582763671875, 0.17635664343833923, 0.22715146839618683, 0.011287800967693329, 0.3052377998828888, -0.22928166389465332, -0.020392529666423798, 0.17751337587833405, 0.27241945266723633, -0.08319976180791855, 0.031114591285586357, 0.44432151317596436, 0.5324329137802124, 0.24929261207580566, -0.1158858984708786, -0.22801092267036438, 0.15634766221046448, -0.30952128767967224, 0.5127819180488586, 0.40903809666633606, 0.13838085532188416, 0.3412439525127411, -0.06733505427837372, 0.619362473487854, 0.011986572295427322, 0.43774038553237915, 0.011442950926721096, -0.5350387096405029, 0.32310357689857483, -0.20136912167072296, 0.21193668246269226, 0.062455371022224426, -0.16929693520069122, -0.41352882981300354, -0.09247880429029465, -0.264919638633728, 0.06823825091123581, -0.08596855401992798, 0.12660856544971466, 0.23639075458049774, -0.035315241664648056, -0.2236129492521286, -0.11679189652204514, -0.6690143346786499, -0.6161139011383057, 0.49043264985084534, -0.06518560647964478, -0.18791842460632324, -0.014121154323220253, 0.7260363698005676, 0.4711220860481262, 0.1678648144006729, -0.1394760012626648, 0.14159990847110748, -0.10620734840631485, 0.4155704975128174, -0.18748454749584198, 0.3460273742675781, -0.2407524585723877, -0.09493027627468109, -0.8075581192970276, -0.23198503255844116, 0.4747055172920227, 0.3815445899963379, -0.08047471195459366, 0.007232117932289839, -0.29319679737091064, -0.025848016142845154, 0.31548643112182617, -0.3454429507255554, 0.4541212022304535, -0.7084976434707642, -0.11466910690069199, -0.5235157012939453, 0.20998813211917877, 0.043219249695539474, -0.433567076921463, -0.43422573804855347, -0.28418347239494324, 0.21003079414367676, -0.25330305099487305, 0.5495608448982239, 0.34806346893310547, -0.43322455883026123, -0.3859204053878784, 0.8276504874229431, -0.6510097980499268, 0.24201861023902893, 0.022191431373357773, 0.19683824479579926, 0.3977731466293335, -0.10627942532300949, -0.2433561533689499, -0.39707452058792114, 0.435043603181839, 0.5643307566642761, -0.22621403634548187, 0.5530437231063843, -0.39141830801963806, 0.09951692074537277, -0.6390292644500732, 0.4929001033306122, -0.09008818119764328, -0.41443219780921936, -0.3542740046977997, -0.09204341471195221, -0.4373859167098999, -0.12662090361118317, -0.46727409958839417, -0.5193484425544739, -0.08149740099906921, -0.509550929069519 ]
OBJECTIVE The authors sought to determine innate immune system activation following psychosocial stress in patients with major depression and increased early life stress. METHOD Plasma interleukin (IL)-6, lymphocyte subsets, and DNA binding of nuclear factor (NF)-kB in peripheral blood mononuclear cells were compared in medically healthy male subjects with current major depression and increased early life stress (N=14) versus nondepressed male comparison subjects (N=14) before and after completion of the Trier Social Stress Test. RESULTS Trier Social Stress Test-induced increases in IL-6 and NF-kappaB DNA-binding were greater in major depression patients with increased early life stress and independently correlated with depression severity, but not early life stress. Natural killer (NK) cell percentages also increased following stress. However, there were no differences between groups and no correlation between NK cell percentage and stress-induced NF-kappaB DNA-binding or IL-6. CONCLUSIONS Male major depression patients with increased early life stress exhibit enhanced inflammatory responsiveness to psychosocial stress, providing preliminary indication of a link between major depression, early life stress and adverse health outcomes in diseases associated with inflammation.
[ 0.001720726490020752, -0.003005832666531205, -0.010171364061534405, 0.008991281501948833, 0.020660458132624626, 0.01848619431257248, 0.010607961565256119, 0.007190973497927189, -0.010254081338644028, 0.0006967280060052872, -0.015512632206082344, 0.005402849521487951, -0.00802079401910305, -0.00017205823678523302, 0.0028497613966464996, 0.020595639944076538, -0.02242504246532917, 0.034062594175338745, 0.00402532983571291, 0.021267004311084747, -0.03841296583414078, 0.002995121758431196, 0.010570627637207508, -0.0014503750717267394, 0.0044747814536094666, 0.020701782777905464, 0.005660636350512505, -0.018934089690446854, -0.009045973420143127, 0.0121877146884799, -0.016472183167934418, 0.008550621569156647, 0.0045517822727561, -0.006835433654487133, -0.002488588448613882, 0.00915618147701025, -0.0017010144656524062, 0.009563935920596123, -0.010107283480465412, -0.005244564265012741, -0.01794595643877983, -0.010654186829924583, 0.007749506272375584, -0.02440430223941803, -0.008738135918974876, -0.032356735318899155, -0.004533660132437944, -0.00567112909629941, 0.005752709228545427, 0.009906214661896229, -0.018130172044038773, -0.024576418101787567, -0.024682264775037766, -0.004407279659062624, -0.0063643679022789, 0.009915322065353394, 0.018539121374487877, 0.019568338990211487, -0.016057102009654045, 0.020043283700942993, 0.0131289754062891, -0.013745985925197601, 0.03175652027130127, -0.016758179292082787, 0.019077353179454803, -0.06657859683036804, -0.0022376058623194695, 0.004064202308654785, -0.002902878448367119, -0.0120753338560462, 0.01872936636209488, 0.0059577906504273415, 0.024467982351779938, 0.0008154232054948807, -0.03746616095304489, -0.011035671457648277, 0.00787512306123972, 0.003883230034261942, 0.019496848806738853, -0.007936211302876472, 0.008026770316064358, -0.006609962321817875, 0.00904147233814001, 0.012501684948801994, -0.014752515591681004, 0.023830581456422806, -0.017259962856769562, -0.018803447484970093, 0.0017526433803141117, 0.048288725316524506, -0.00999598391354084, -0.008224068209528923, -0.009323788806796074, 0.004806227050721645, 0.01167692244052887, -0.005527162924408913, -0.009303665719926357, -0.014537040144205093, 0.0054547348991036415, -0.02424641139805317, -0.02763739600777626, -0.012139909900724888, 0.02623242512345314, 0.004963170737028122, 0.017688659951090813, 0.006609953474253416, 0.0012301309034228325, 0.01642988994717598, 0.01687045581638813, 0.01052421610802412, 0.0006683567771688104, 0.000527319498360157, -0.018224172294139862, 0.019029591232538223, 0.005117913708090782, -0.01869257539510727, -0.024512801319360733, 0.015430795960128307, 0.0056467074900865555, -0.013588682748377323, -0.0012690539006143808, 0.002561378525570035, -0.008237581700086594, 0.004666049033403397, -0.000426693819463253, 0.0176762193441391, -0.02721695974469185, 0.008185874670743942, 0.004534520208835602, 0.0014096223749220371, -0.006057507824152708, 0.01668822392821312, 0.010412129573523998, 0.001450474257580936, -0.017273569479584694, -0.005835574585944414, 0.003768429160118103, 0.026107344776391983, -0.019665194675326347, -0.0031708423048257828, -0.013527498580515385, 0.009451598860323429, -0.0023271581158041954, 0.01642611064016819, -0.01124647818505764, 0.0017691303510218859, 0.0009813301730901003, -0.010357165709137917, -0.00564704742282629, 0.004386304412037134, 0.021636690944433212, -0.004883044399321079, 0.014348207041621208, -0.0199755672365427, -0.007177491672337055, 0.004974330775439739, -0.02243874967098236, -0.012023117393255234, 0.0035864918027073145, 0.00399829912930727, 0.005132933612912893, -0.012214172631502151, 0.015868322923779488, 0.009205833077430725, 0.011131903156638145, -0.0017603046726435423, -0.011047609150409698, -0.015103209763765335, -0.004160106182098389, 0.010915004648268223, -0.002885018941015005, 0.007494391407817602, 0.0120871402323246, 0.00704951910302043, -0.003760347608476877, 0.004773965571075678, 0.016323929652571678, 0.007888728752732277, -0.006856408901512623, 0.06587868183851242, -0.0006285849958658218, 0.03832636773586273, 0.010317239910364151, -0.026762936264276505, 0.017979152500629425, -0.014287163503468037, 0.020089134573936462, -0.009507320821285248, -0.03408592566847801, 0.00751244043931365, -0.004496114794164896, -0.006473715417087078, 0.005090727005153894, 0.00364623311907053, -0.028725354000926018, 0.003098087850958109, 0.026331065222620964, 0.002599352039396763, 0.007262947037816048, 0.01116121094673872, 0.01410546712577343, -0.0117710055783391, 0.03617814928293228, -0.0023435703478753567, -0.018643155694007874, 0.013515325263142586, 0.022083302959799767, 0.006373018957674503, -0.0024601570330560207, -0.03136517107486725, 0.028162704780697823, -0.023781906813383102, 0.009895513765513897, -0.014948055148124695, 0.005054248496890068, -0.002724569523707032, -0.0040837302803993225, 0.027643486857414246, -0.007463687099516392, -0.011405041441321373, 0.004964316729456186, 0.023126699030399323, 0.008498432114720345, 0.009650365449488163, 0.020882640033960342, -0.03740140050649643, 0.0029450992587953806, 0.007889593951404095, -0.019597241654992104, 0.006767330691218376, -0.030535252764821053, -0.01525148656219244, -0.010103272274136543, -0.00039960118010640144, -0.004528910852968693, 0.01886175200343132, 0.01106616947799921, -0.004170388914644718, 0.013907358050346375, -0.013112450018525124, -0.02065015770494938, -0.004003629088401794, 0.025540843605995178, 0.013582284562289715, 0.0054535698145627975, -0.008074235171079636, -0.007054778281599283, 0.017853355035185814, 0.006322098895907402, 0.0011360333301126957, 0.008597326464951038, -0.00539408391341567, -0.007223162800073624, -0.03585422784090042, 0.008929910138249397, -0.011667553335428238, 0.0241275355219841, -0.016700804233551025, 0.026137245818972588, -0.008652716875076294, 0.00666546355932951, 0.00958998128771782, -0.004727013409137726, 0.014446375891566277, -0.01791352406144142, -0.021605145186185837, 0.007278390694409609, 0.012792493216693401, 0.002635161392390728, -0.027672503143548965, 0.009104701690375805, -0.005974610801786184, 0.0029145837761461735, -0.08175994455814362, -0.007264404091984034, -0.015187455341219902, 0.019809678196907043, 0.005277950316667557, -0.008980454877018929, 0.014003833755850792, 0.0189984031021595, -0.006601960398256779, -0.021446796134114265, 0.0032426556572318077, 0.0051590255461633205, -0.009412743151187897, -0.02521529793739319, 0.013054773211479187, 0.003216963727027178, 0.008176935836672783, -0.012437723577022552, -0.03023131564259529, -0.019206445664167404, -0.006968958303332329, -0.02788078412413597, 0.011742589995265007, 0.030168339610099792, 0.020636804401874542, 0.03172611445188522, 0.028009746223688126, -0.019632037729024887, 0.0008327614050358534, 0.0190000981092453, -0.015822121873497963, -0.00042042694985866547, -0.00849723070859909, 0.025126764550805092, 0.009052480570971966, 0.003645663382485509, -0.012062087655067444, -0.011799493804574013, -0.014365898445248604, 0.02780986949801445, 0.0007383344927802682, 0.000809346791356802, -0.00019606424029916525, -0.0025802934542298317, 0.017747318372130394, -0.010917944833636284, -0.017045030370354652, 0.04536587744951248, 0.00930691696703434, -0.004567193798720837, 0.004779927432537079, 0.008029315620660782, 0.0006678085774183273, 0.013264365494251251, -0.007575318682938814, -0.013518910855054855, -0.010268418118357658, 0.011752991005778313, -0.004210266284644604, -0.011189321056008339, 0.010214694775640965, -0.014294389635324478, 0.03138767555356026, 0.011021035723388195, -0.011249218136072159, 0.02069270983338356, 0.00910383090376854, 0.016202177852392197, -0.03857079893350601, 0.025396885350346565, -0.0012157283490523696, -0.00508685689419508, -0.013856707140803337, -0.007123375311493874, -0.02115485444664955, -0.00814893003553152, -0.013250133953988552, -0.015057490207254887, 0.00048119062557816505, -0.0020099624525755644, -0.02239450067281723, -0.005014108493924141, 0.0020296848379075527, -0.022491298615932465, -0.012701071798801422, -0.028274331241846085, 0.003182424698024988, 0.03283441439270973, 0.014605444855988026, -0.012033000588417053, 0.008801667019724846, 0.007026178762316704, 0.018138768151402473, 0.013022052124142647, -0.005053295753896236, 0.002710559405386448, -0.018206384032964706, -0.003068996127694845, -0.0015342539409175515, 0.007395278196781874, -0.01682862639427185, -0.006267230026423931, -0.007989133708178997, -0.010883343406021595, -0.011055405251681805, 0.010683940723538399, 0.014417593367397785, 0.019188115373253822, -0.010492595843970776, -0.0018156140577048063, 0.019310198724269867, 0.0034284968860447407, -0.009507796727120876, 0.006133482325822115, 0.005264056380838156, 0.00232927268370986, 0.0033464226871728897, 0.001917265821248293, 0.0720495656132698, -0.008128799498081207, 0.00924326665699482, -0.011570229195058346, 0.02926398441195488, -0.008229211904108524, 0.006661985069513321, 0.01712641678750515, -0.007970906794071198, -0.01794288121163845, 0.012993322685360909, 0.01876727119088173, -0.004623253829777241, 0.01744702085852623, -0.004516334738582373, 0.0010594036430120468, -0.014129877090454102, -0.004213428124785423, 0.01940254122018814, -0.0017096615629270673, 0.01426025852560997, -0.017456484958529472, -0.010833384469151497, -0.016545720398426056, 0.01209060475230217, -0.04801424592733383, -0.007232582196593285, -0.011301427148282528, -0.013227017596364021, 0.008518964052200317, 0.005388950929045677, -0.008270081132650375, -0.008280996233224869, 0.014052661135792732, 0.022143159061670303, 0.007901483215391636, 0.008711314760148525, -0.013397682458162308, -0.009907294064760208, 0.0013936562463641167, -0.02835405245423317, -0.021235091611742973, 0.005463208071887493, 0.01034398190677166, -0.021134385839104652, 0.019966568797826767, 0.017546283081173897, -0.009197036735713482, -0.014462701044976711, 0.0033426997251808643, -0.013935470022261143, 0.020834671333432198, 0.013149548321962357, 0.01571398600935936, -0.011877534911036491, 0.012326947413384914, 0.029111187905073166, 0.003542864928022027, -0.014009363017976284, 0.00037315464578568935, 0.011725034564733505, -0.017493942752480507, 0.01488178689032793, -0.004964180290699005, 0.010369934141635895, -0.020244717597961426, 0.0006068013608455658, 0.004235409200191498, -0.017016947269439697, -0.023029247298836708, 0.02367304638028145, -0.01826447807252407, -0.015358366072177887, 0.019247639924287796, -0.0027801450341939926, 0.0005021784454584122, -0.002181755844503641, -0.003673301078379154, 0.009519975632429123, -0.014508495107293129, -0.038652632385492325, 0.0046480274759233, 0.005028311628848314, -0.017883727326989174, -0.01574290171265602, -0.022483166307210922, -0.0037792460061609745, -0.07473532855510712, -0.00009734765626490116, 0.004996868781745434, -0.01065833680331707, -0.023524221032857895, 0.004085546359419823, -0.004229377023875713, 0.021929524838924408, -0.016235481947660446, -0.0032776412554085255, -0.003537362441420555, 0.005146251991391182, -0.018579324707388878, -0.014382844790816307, 0.0103470329195261, -0.021321535110473633, 0.0014408831484615803, 0.00551798939704895, -0.010499974712729454, -0.018048111349344254, -0.012472208589315414, 0.009729642421007156, -0.01795661449432373, 0.0026797873433679342, 0.007208352442830801, -0.08105543255805969, 0.009194067679345608, -0.011500716209411621, -0.010107296518981457, -0.01919669099152088, -0.0027031181380152702, 0.021439749747514725, -0.010651546530425549, -0.007673716172575951, -0.014135017991065979, 0.009632205590605736, 0.01088745053857565, 0.00024795159697532654, -0.010706142522394657, 0.009337157011032104, -0.005915344692766666, 0.009383429773151875, 0.01539497822523117, -0.0002497571986168623, -0.034077100455760956, -0.005685355514287949, 0.0021955007687211037, -0.003208073088899255, 0.006345019210129976, -0.010159063152968884, -0.029056303203105927, -0.013954597525298595, 0.01050872728228569, 0.0027267690747976303, -0.007313766982406378, 0.011773902922868729, -0.029500681906938553, -0.010971646755933762, -0.0017161774449050426, -0.01121068187057972, -0.009934850037097931, 0.0015875149983912706, -0.008099138736724854, 0.04071015119552612, 0.0014939478132873774, -0.009401841089129448, 0.025281600654125214, 0.02017316408455372, 0.030982106924057007, -0.0030949062202125788, -0.01628868654370308, 0.004520472604781389, -0.009716428816318512, 0.007775310426950455, -0.011872448958456516, 0.012257044203579426, 0.002719597890973091, -0.00503281457349658, 0.016104519367218018, 0.008751322515308857, 0.005540873855352402, -0.014349658042192459, 0.01621956191956997, 0.0004883487708866596, 0.007547370158135891, -0.0029381050262600183, 0.010591676458716393, 0.007435542996972799, 0.07129596173763275, -0.023466676473617554, 0.006271046120673418, -0.008137788623571396, 0.0031581728253513575, -0.0008875925559550524, -0.0022624609991908073, -0.022054128348827362, 0.0011232802644371986, -0.013335061259567738, -0.03192462399601936, -0.015627525746822357, -0.005259926896542311, 0.019028348848223686, 0.01918301172554493, -0.03332109749317169, -0.014444914646446705, -0.02229781448841095, -0.009809978306293488, 0.03384648635983467, 0.04281400889158249, -0.005710313096642494, -0.03418499231338501, 0.009274741634726524, 0.018068060278892517, -0.011044381186366081, -0.007045363541692495, 0.021229034289717674, 0.0063433959148824215, 0.02548665925860405, -0.011132885701954365, -0.01285226084291935, 0.0047754161059856415, -0.0004485398530960083, 0.014235255308449268, 0.01279707532376051, 0.002933632582426071, 0.010312186554074287, -0.012756641954183578, 0.03618872910737991, 0.011832845397293568, 0.000940490048378706, -0.0018097537104040384, -0.01876966655254364, -0.002307516522705555, 0.021152544766664505, 0.006506912410259247, 0.008125548250973225, -0.0026052093598991632, 0.015485127456486225, 0.023620430380105972, 0.006574290804564953, 0.023932088166475296, 0.013301104307174683, -0.01958048716187477, 0.028227530419826508, -0.012144466862082481, 0.014387816190719604, -0.027843769639730453, -0.01685502380132675, -0.007033545523881912, -0.022112606093287468, 0.018552608788013458, -0.023097386583685875, 0.00695319939404726, -0.01013997569680214, 0.01576238125562668, -0.013131438754498959, -0.009101144969463348, 0.013877714984118938, 0.005432299803942442, -0.00904187373816967, 0.006150669418275356, 0.009720890782773495, 0.01795128732919693, 0.024286378175020218, 0.026904426515102386, -0.017190201207995415, 0.009031994268298149, -0.005766609217971563, -0.010421001352369785, 0.020877311006188393, -0.02442648820579052, 0.0075279660522937775, 0.016745850443840027, -0.00038643088191747665, 0.00458397064357996, 0.010308053344488144, 0.00018722214736044407, 0.008695939555764198, -0.01059635542333126, 0.007048292085528374, 0.002230927348136902, 0.02338198572397232, 0.005663297139108181, 0.03507605940103531, 0.0246325321495533, 0.0006440303404815495, -0.0012020531576126814, -0.0010362276807427406, -0.0097675621509552, 0.009254655800759792, -0.021345501765608788, 0.019427716732025146, 0.006303442642092705, -0.001410431694239378, 0.011117273941636086, 0.003424093360081315, 0.004839630331844091, 0.025180315598845482, -0.02019401825964451, -0.016028819605708122, 0.005786730442196131, 0.01713624969124794, 0.0013794424012303352, 0.01570037566125393, -0.002702354686334729, -0.03567998483777046, -0.000865250127390027, -0.013921838253736496, 0.014006447978317738, 0.006427028216421604, -0.023575585335493088, -0.011376389302313328, 0.0314752459526062, -0.03176754713058472, -0.011150461621582508, 0.0028741289861500263, 0.005880823824554682, -0.000630401074886322, 0.01938498765230179, -0.024559568613767624, -0.014040205627679825, 0.009690728969871998, -0.006327052600681782, -0.01270478218793869, 0.03764119744300842, 0.0006039596628397703, 0.002165458397939801, -0.0018530443776398897, 0.029622191563248634, -0.009648901410400867, 0.0016659650718793273, -0.03768901154398918, 0.006470445077866316, -0.023987282067537308, 0.018864799290895462, -0.0002331845462322235, 0.018537629395723343, -0.003915178589522839, -0.0032183490693569183, 0.0036801653914153576, -0.014117015525698662, -0.0032047617714852095, 0.02258649282157421, 0.009332588873803616, -0.008092476986348629, -0.006368580274283886, 0.002239393536001444, -0.0037593436427414417, 0.003597655799239874, -0.009352723136544228, 0.007567738648504019, -0.005925262346863747, -0.01433313637971878, -0.011922718957066536, 0.015966936945915222, 0.014671599492430687, -0.02245718613266945, -0.02061629109084606, 0.018166042864322662, -0.014869000762701035, 0.012376786209642887, 0.027580568566918373, -0.004263806156814098, -0.006981039885431528, 0.0062838587909936905, 0.021077144891023636, 0.0007238844409584999, 0.005833546631038189, 0.02275216579437256, -0.015047023072838783, -0.004085702355951071, -0.017388302832841873, 0.006390338763594627, -0.002739875577390194, -0.00013930449495092034, 0.0066810669377446175, 0.0022630358580499887, 0.004527371376752853, -0.016548965126276016, -0.013162723742425442, -0.00017140619456768036, 0.0200963132083416, -0.011796623468399048, 0.0013315072283148766, -0.008385829627513885, -0.014380759559571743, -0.013614164665341377, -0.007931698113679886, -0.00037317501846700907, -0.022675812244415283 ]
[ 0.15488800406455994, -0.11220499873161316, 0.23163211345672607, 0.20166127383708954, -0.36147192120552063, 0.541659951210022, 0.08689793199300766, -0.3895004391670227, -0.021899057552218437, -0.1218026727437973, 0.32814720273017883, 0.7616961002349854, -0.06775916367769241, -0.3083864748477936, 0.09075796604156494, 0.9293662905693054, 0.381529837846756, -0.0011157601838931441, -0.05548129230737686, -0.6352810859680176, 0.05575786530971527, -0.5483242869377136, 0.31620779633522034, -0.10121582448482513, 0.1742209643125534, 0.28409233689308167, 0.6863958835601807, -0.15257234871387482, -0.03445181995630264, -0.03981836140155792, -0.27482062578201294, 0.5909443497657776, -0.15065057575702667, -0.282928466796875, -0.3503970801830292, 0.4474564492702484, 0.11983615905046463, -0.25292277336120605, 0.25797051191329956, -0.48893502354621887, 0.1901581734418869, -0.5171896815299988, -0.4487186670303345, 0.5819424986839294, -0.47487813234329224, -0.5128923058509827, -1.4742591381072998, 0.2122163623571396, -0.14666464924812317, 0.2916924059391022, -0.0520755834877491, 0.44868025183677673, -0.16573482751846313, 0.42107507586479187, -0.19898246228694916, 0.4788147509098053, -0.24312876164913177, -0.5337861776351929, 0.2658579349517822, -0.31682801246643066, 0.14079682528972626, -0.03398871049284935, 0.21218927204608917, 0.42955175042152405, -0.1932613104581833, 0.4374839663505554, -0.08122150599956512, 0.038511086255311966, -0.5850395560264587, -0.4420177936553955, -0.020664488896727562, 0.043082673102617264, -0.5881741046905518, 0.24392348527908325, -0.02830345369875431, 0.07946918159723282, -0.11580837517976761, -0.13265861570835114, 0.3086397051811218, 0.2869745194911957, 0.6009101271629333, -0.040901072323322296, 0.25773462653160095, -0.4358523190021515, 0.2715175747871399, 0.4702763855457306, 0.05375346168875694, 0.2814369201660156, -0.415591299533844, -0.25836601853370667, 0.11574255675077438, -0.5103663802146912, 0.31355956196784973, 0.5563738346099854, 0.16038347780704498, 0.35799098014831543, 0.32762834429740906, -0.10857848078012466, 0.027194034308195114, 0.15315060317516327, 0.056068554520606995, 0.3125717341899872, -0.4596806466579437, -0.1673165112733841, -0.8551128506660461, 0.0049299877136945724, -0.1418611854314804, -1.0099334716796875, -0.8410799503326416, 0.24467329680919647, -0.8552061319351196, 0.4399295449256897, -0.12127376347780228, -0.36546626687049866, -0.3761347830295563, -0.15369179844856262, 0.4374827742576599, -0.2394043654203415, -0.31414100527763367, 0.8433491587638855, 0.2716061770915985, 1.0392868518829346, -0.05545606464147568, 0.4305596649646759, 0.030315300449728966, -0.0671965628862381, 0.32396048307418823, 0.4867284297943115, 0.23906587064266205, 0.5716550350189209, 0.0804213434457779, 0.21377143263816833, -0.18093959987163544, 0.04438530281186104, -0.12822555005550385, -0.6749251484870911, 0.04768794775009155, -0.007931236177682877, -0.08982055634260178, -0.0031853399705141783, -0.7870548963546753, -0.9434472322463989, -0.07632925361394882, -0.4212809205055237, 0.10646374523639679, -0.6362430453300476, 0.0034955174196511507, 0.24112023413181305, 0.06434917449951172, -0.22763453423976898, 0.28455761075019836, -0.14913472533226013, -0.36272361874580383, -0.3252164125442505, -0.20943820476531982, 0.4382908046245575, -0.465020090341568, -0.16293887794017792, -0.05554331839084625, 0.34705832600593567, 0.3269274830818176, 0.3492498993873596, -0.7087961435317993, -0.3288073241710663, 0.5903551578521729, -0.22539377212524414, 0.31095412373542786, 0.26874905824661255, 0.08147788047790527, -0.1815960556268692, -0.24396419525146484, -0.4594038724899292, 0.21971969306468964, -0.4311382472515106, -0.49248480796813965, -0.11628035455942154, 0.3106321692466736, 0.03686218708753586, 0.07172732055187225, -0.032877884805202484, -0.4702373147010803, 0.04088785871863365, -0.10459782183170319, -0.6143873333930969, 0.21597883105278015, 0.18359866738319397, 0.32628071308135986, -0.22256654500961304, -0.06836108863353729, 0.32116004824638367, 0.08262013643980026, -0.20019131898880005, 0.7422049641609192, -0.6788711547851562, 1.344866156578064, -0.719253659248352, -0.5533667802810669, 1.1485334634780884, 0.08864238858222961, -0.06415454298257828, 0.13375386595726013, -0.16188788414001465, 0.6330799460411072, -0.23150618374347687, -0.37786686420440674, -0.043155863881111145, -0.049231912940740585, -0.10097372531890869, -0.9681527614593506, 0.5525460839271545, 0.3249469995498657, 0.16397124528884888, -0.12023692578077316, -0.07779711484909058, 0.10240523517131805, 0.1489126831293106, -0.2393789440393448, 0.2718507647514343, -0.08639255911111832, 0.1726691871881485, 0.4235096573829651, -0.49165067076683044, 0.12714524567127228, 0.39758503437042236, -0.34468549489974976, 0.616497814655304, 0.6763820648193359, -0.0862077921628952, 0.8059690594673157, -0.7070315480232239, -0.03313469886779785, -0.18712164461612701, 0.5449607968330383, -0.4533122479915619, -0.10610033571720123, 0.31114789843559265, 0.09896214306354523, -0.12002511322498322, 0.6888173818588257, 0.23922882974147797, -0.1509922742843628, 0.40918922424316406, -0.2217956930398941, 0.13353946805000305, 0.06233322247862816, 0.10332784801721573, -0.18268254399299622, 0.6067712306976318, -0.8268887996673584, -0.0650150254368782, -0.026569349691271782, 0.38877949118614197, -0.18691173195838928, -0.05384685471653938, 0.3186130225658417, 0.019697250798344612, 0.03144560381770134, -0.4409904479980469, 0.18120966851711273, -0.03474966809153557, -0.23333805799484253, -0.004563839174807072, 0.21186226606369019, -0.13969014585018158, 0.3854486644268036, -0.7460080981254578, -0.7987008094787598, -0.13351058959960938, 0.6243619918823242, 0.5473148226737976, 0.7511449456214905, 0.16684849560260773, -0.35413509607315063, 0.4231967628002167, 0.17147484421730042, -0.2287694364786148, -0.046605225652456284, 0.6207752227783203, -0.7482960224151611, -0.6023685336112976, -0.029153116047382355, -0.11174489557743073, 0.7405329942703247, 0.41993075609207153, 0.0250993724912405, -0.258396178483963, -0.06213922053575516, -0.655680239200592, -0.24792218208312988, -0.6900103092193604, 0.10993122309446335, 0.8395565748214722, 0.09585186094045639, -0.5026913285255432, 0.32306939363479614, 0.2917841672897339, -0.15738719701766968, 0.7034389972686768, 0.3691997528076172, -0.2340802401304245, -0.1859021931886673, 0.37875881791114807, -0.13587500154972076, -0.43541693687438965, 0.15603528916835785, 0.18645666539669037, -0.20632685720920563, 0.4089307188987732, -6.064329147338867, 0.15054896473884583, -0.7555268406867981, 0.07214292883872986, -0.35400059819221497, -0.030193740501999855, 0.5296170711517334, -0.007726452779024839, -0.07767512649297714, -0.1956082284450531, 0.032285094261169434, 0.1336260288953781, 0.06184694543480873, 0.5597096085548401, 0.05561547726392746, 0.1878829449415207, 0.35611680150032043, -0.19768519699573517, 0.47147613763809204, 0.4722350537776947, -0.26989901065826416, -0.3497586250305176, -0.08400388062000275, 0.26717737317085266, 0.5849558115005493, 0.0786639079451561, -0.7270064949989319, 0.1858656108379364, 0.4533843994140625, -0.22323019802570343, 0.29247769713401794, -0.6314732432365417, -0.1688513606786728, -0.08624377101659775, 0.5428048968315125, 0.20096881687641144, 0.4097238779067993, -0.08634819090366364, 0.46989110112190247, -0.45988690853118896, -0.0748102068901062, 0.2032250165939331, -0.23674307763576508, -0.44551703333854675, -0.07531829923391342, -0.1711495816707611, -0.20199759304523468, 0.45873454213142395, -0.36342716217041016, 0.2948809564113617, 0.19344624876976013, -0.10878138989210129, -0.2829141318798065, 0.2614367604255676, 0.1703581064939499, -0.17997896671295166, 0.10767729580402374, 0.2546411156654358, -0.8262094259262085, 0.5717619061470032, 0.24466702342033386, -0.003968332894146442, -0.21066856384277344, -0.6771761178970337, -0.5850473642349243, 0.27330389618873596, -0.4335176348686218, -0.5078948140144348, 0.17227984964847565, 0.02008913643658161, -0.2532562017440796, -0.10271646082401276, 0.18262387812137604, -0.6581479907035828, -0.12059063464403152, -0.27940666675567627, 0.2539563477039337, 0.023883452638983727, 0.019483640789985657, -0.23485800623893738, -0.33513543009757996, -0.781055212020874, 0.14209868013858795, 0.2745437026023865, 0.02022380568087101, 0.4977481961250305, 0.17473238706588745, 0.45933863520622253, -0.1960420459508896, 0.21508078277111053, 0.09465107321739197, -0.28602564334869385, -0.0656488686800003, 0.6812387704849243, -0.2527744770050049, 0.09566539525985718, 0.9645682573318481, 0.14956922829151154, 0.49565836787223816, 0.25511011481285095, 0.5928550362586975, 0.0863582044839859, -0.15212278068065643, -0.7884652614593506, -0.16823074221611023, 0.08250921964645386, -0.47329771518707275, -0.10173780471086502, 0.9416565895080566, -0.9648772478103638, 0.029717518016695976, 0.2351538985967636, 0.08237408101558685, -0.13872773945331573, 0.698715090751648, -0.03776286914944649, -0.03523983061313629, 0.030439255759119987, 0.3329632878303528, -0.13490909337997437, 0.16571591794490814, 0.09550848603248596, -0.6052616238594055, -0.126252681016922, -0.3746449947357178, -0.26080650091171265, 0.05675138905644417, 0.5128618478775024, -1.028243064880371, 0.2242565155029297, 0.332831472158432, 0.561288058757782, -0.2843616306781769, -0.10504310578107834, 0.2703709304332733, -0.47015896439552307, -0.3190685212612152, 0.19242556393146515, 0.6318272948265076, -0.07459520548582077, 0.6025201678276062, -0.06952627748250961, 0.06572771072387695, -0.023072583600878716, -0.06792619824409485, -0.16285821795463562, -0.13135561347007751, -0.6065430045127869, -0.5169134736061096, -0.36169368028640747, 0.3884285092353821, -0.0014778883196413517, 0.261136919260025, 0.4035504162311554, 0.08004337549209595, 0.27245813608169556, 0.38038957118988037, -0.14617450535297394, 0.11191464215517044, -0.6955140233039856, 0.5852218866348267, 0.10305705666542053, -0.7433936595916748, -0.4332573711872101, 0.07937034964561462, -0.23538638651371002, -0.11161700636148453, -0.16794784367084503, 0.03836096450686455, 0.08356460928916931, 0.06130646541714668, -0.40808790922164917, 0.09377627819776535, -0.10085074603557587, -0.2404632717370987, 0.04769439622759819, -0.36057254672050476, -0.33453619480133057, -0.18765094876289368, 0.08542318642139435, 0.2529536187648773, -0.3723613917827606, -0.2196468859910965, 0.10069683939218521, 0.75986647605896, 0.3132256269454956, -0.02396245487034321, 0.1655663251876831, -0.350353866815567, -0.026060808449983597, -0.08175467699766159, -0.026555722579360008, 0.3465632498264313, 0.19429275393486023, -0.3935350477695465, -0.03729454055428505, 0.40141546726226807, 0.10164079815149307, 0.040188197046518326, 0.0613105334341526, -0.03995884582400322, 0.29573166370391846, -0.015299320220947266, 0.2526954412460327, 0.025754163041710854, -0.09234385937452316, -0.42470481991767883, -0.09844493120908737, -0.2514427900314331, 0.05714508146047592, -0.04760368913412094, -0.5042129158973694, -0.06481100618839264, 0.1094493567943573, -0.1802118867635727, 0.12036831676959991, 0.1219097301363945, -0.391461580991745, -0.3754956126213074, 0.498440682888031, 0.2845715582370758, 0.14769905805587769, -0.14399166405200958, 0.19256854057312012, 0.02042161300778389, -0.24467943608760834, 0.9641036987304688, -0.7632104754447937, 0.2159707099199295, 0.48513612151145935, -0.1902855634689331, 0.15818803012371063, 0.16809077560901642, 0.35631880164146423, -0.45724692940711975, -0.3553239703178406, -0.5940055251121521, 0.6087308526039124, -0.07357792556285858, -0.328520804643631, 0.09974823147058487, 0.6748749613761902, -0.2625635862350464, -0.07949867844581604, 0.32593974471092224, 0.3669085204601288, 0.08613864332437515, -0.38595885038375854, -0.3165168762207031, -0.01694582961499691, -0.17489349842071533, -0.36007964611053467, 0.1610061526298523, 0.08126749843358994, 0.7332115173339844, -0.08917931467294693, -0.10679271072149277, -0.07053907960653305, -0.26957568526268005, 0.31100958585739136, -0.06143100932240486, -0.3004555404186249, -0.1921413391828537, 0.07705327868461609, -0.19276569783687592, 0.2570401132106781, 0.2419578731060028, -0.3359750509262085, 0.03584422916173935, -0.14087706804275513, -0.006965332198888063, -0.06730988621711731, 0.4217201769351959, 0.6516560316085815, 0.051240187138319016, -0.4186895191669464, -0.14132095873355865, 0.39503827691078186, 0.10257458686828613, -0.11839696019887924, 0.005572332069277763, -0.21408496797084808, 0.5118441581726074, -0.4116850793361664, 0.2274337112903595, -0.4170491695404053, -0.05235433951020241, 0.223114013671875, -0.46334388852119446, -0.31564345955848694, 0.14802181720733643, 0.010529182851314545, -0.6458471417427063, -0.823526918888092, -0.24096348881721497, 0.5130568146705627, -0.014576595276594162, 0.4737093150615692, 0.16034641861915588, 0.04915722459554672, -0.5277262330055237, 0.5475171804428101, 0.2679605185985565, -0.4150056838989258, -0.3545563817024231, 0.25635474920272827, 0.3227636516094208, -0.30748727917671204, -0.21258330345153809, 0.04945211112499237, 0.08737227320671082, 0.06697991490364075, 0.2154754102230072, -0.002514229854568839, -0.6464945077896118, 0.09482217580080032, 0.0634567141532898, -0.0938873216509819, 0.6634608507156372, 0.5283186435699463, -0.192600816488266, 0.5131859183311462, 0.7461197972297668, 0.22344601154327393, -0.6954982280731201, 0.26540425419807434, 0.03974836319684982, 0.652796745300293, 0.3216490149497986, 0.42148494720458984, 0.5712628960609436, 0.4033755660057068, -0.10788622498512268, 0.5373134613037109, 0.06010739132761955, 0.3172261714935303, -0.046801984310150146, -0.3266043961048126, 0.09858040511608124, 0.24713397026062012, 0.8420674800872803, 0.6217461824417114, 0.08395842462778091, -0.3953680992126465, -0.231194868683815, 0.36367014050483704, -0.3264373540878296, 0.2240356206893921, -0.3662644922733307, 0.4643494784832001, 0.010146056301891804, -0.23521223664283752, -0.2660137712955475, -0.13087941706180573, -0.5874968767166138, -0.13862751424312592, 0.11864876747131348, -0.32905876636505127, -1.0338488817214966, -0.030080247670412064, -0.036358047276735306, 0.35958486795425415, 0.025611896067857742, 0.15761981904506683, -0.66265469789505, -0.3011171519756317, 0.6311373710632324, 0.4286253750324249, 0.2784148156642914, 0.007313624490052462, -0.23764283955097198, -0.08391287177801132, -0.04548478126525879, 0.07885333150625229, -0.0016541496152058244, -0.4545668065547943, 0.24820832908153534, -0.12208613008260727, -0.15350671112537384, 0.2898320257663727, -0.127348393201828, -0.08764034509658813, -0.2746260464191437, -0.5375635623931885, -0.44679003953933716, -0.23191867768764496, -0.19607196748256683, -0.2344166338443756, 0.2565484344959259, -0.20220720767974854, 0.09494787454605103, -0.19074979424476624, 0.40465790033340454, 0.3206084966659546, -0.4025733172893524, -0.029108669608831406, -0.32562732696533203, 0.18877804279327393, 0.23522761464118958, 0.23495733737945557, -0.4111635982990265, 0.32099780440330505, -0.05700063705444336, 0.032161954790353775, -0.35538020730018616, 0.2130703330039978, -0.2819301187992096, -0.03922159597277641, -0.331499844789505, -0.3734249472618103, 0.6336161494255066, 0.0677313506603241, -0.5071362257003784, 0.16903984546661377, 0.12782573699951172, -0.0971495658159256, 0.3298133313655853, 0.03342946246266365, -0.05661298334598541, 0.15287990868091583, -0.2594740688800812, 0.029133517295122147, 0.17009949684143066, -0.26172903180122375, -0.6509891152381897, 0.20823733508586884, -0.07306292653083801, 0.03803396597504616, 0.13704970479011536, -0.01525137573480606, -0.49180975556373596, -0.4304496943950653, -0.4191654324531555, 0.19226068258285522, -0.6230965256690979, 0.21297648549079895, 0.06163615360856056, -0.0853913202881813, 0.3101251423358917, -0.1315573900938034, -0.17869234085083008, -0.25284725427627563, 0.4298032522201538, -0.023153094574809074, 0.3412894904613495, 0.6801875829696655, -0.004918311722576618, -0.3212939500808716, -0.26486802101135254, 0.45688679814338684, -0.4324089586734772, 0.26994961500167847, -0.0498092882335186, -0.13534709811210632, -0.5128156542778015, -0.07427366077899933, 0.4401698410511017, -0.6844230890274048, -0.038904182612895966, -0.08728016167879105 ]
We cloned a new member of the murine brain kinesin superfamily, KIF3B, and found that its amino acid sequence is highly homologous but not identical to KIF3A, which we previously cloned and named KIF3 (47% identical). KIF3B is localized in various organ tissues and developing neurons of mice and accumulates with anterogradely moving membranous organelles after ligation of nerve axons. Immunoprecipitation assay of the brain revealed that KIF3B forms a complex with KIF3A and three other high molecular weight (approximately 100 kD)-associated polypeptides, called the kinesin superfamily-associated protein 3 (KAP3). In vitro reconstruction using baculovirus expression systems showed that KIF3A and KIF3B directly bind with each other in the absence of KAP3. The recombinant KIF3A/B complex (approximately 50-nm rod with two globular heads and a single globular tail) demonstrated plus end-directed microtubule sliding activity in vitro. In addition, we showed that KIF3B itself has motor activity in vitro, by making a complex of wild-type KIF3B and a chimeric motor protein (KIF3B head and KIF3A rod tail). Subcellular fractionation of mouse brain homogenates showed a considerable amount of the native KIF3 complex to be associated with membrane fractions other than synaptic vesicles. Immunoprecipitation by anti-KIF3B antibody-conjugated beads and its electron microscopic study also revealed that KIF3 is associated with membranous organelles. Moreover, we found that the composition of KAP3 is different in the brain and testis. Our findings suggest that KIF3B forms a heterodimer with KIF3A and functions as a new microtubule-based anterograde translocator for membranous organelles, and that KAP3 may determine functional diversity of the KIF3 complex in various kinds of cells in vivo.
[ -0.016910148784518242, 0.007523134350776672, 0.00542079471051693, 0.034028589725494385, -0.007024142891168594, -0.007708054501563311, 0.010133055970072746, 0.020424824208021164, -0.01741582155227661, 0.01378091610968113, 0.0068101463839411736, 0.006443479098379612, -0.005822749808430672, 0.010553460568189621, -0.03214007243514061, 0.00843542069196701, -0.023156391456723213, 0.029391637071967125, 0.016527075320482254, -0.009606979787349701, 0.0011744839139282703, -0.011958434246480465, 0.011064432561397552, 0.004520086105912924, 0.027082597836852074, -0.009251895360648632, -0.02723860926926136, -0.010400524362921715, 0.01427922211587429, -0.00008492358028888702, 0.01836094632744789, 0.009731490164995193, -0.04708563908934593, 0.021389320492744446, 0.0032391438726335764, 0.003045528195798397, -0.013403153978288174, 0.038380708545446396, 0.007880091667175293, -0.003245007013902068, -0.0014301198534667492, -0.01684931293129921, 0.011514812707901001, 0.01401745155453682, -0.011082982644438744, -0.0025381084997206926, -0.0013336879201233387, -0.0009201206266880035, -0.014626620337367058, -0.0027848882600665092, -0.013585318811237812, -0.029449734836816788, -0.0250767320394516, 0.033818621188402176, -0.00658252090215683, -0.002353101037442684, 0.0192687027156353, -0.02719171531498432, 0.0051601058803498745, -0.013777047395706177, 0.013189807534217834, -0.0010997923091053963, 0.006618378683924675, -0.018732545897364616, -0.0008042447734624147, -0.06647396087646484, -0.0184280164539814, 0.03182419016957283, -0.0036108747590333223, 0.0003002430312335491, 0.007131251506507397, 0.0055356621742248535, 0.01405388955026865, -0.002682692836970091, -0.008225645869970322, -0.023655515164136887, -0.026344142854213715, 0.018137343227863312, -0.008400572463870049, -0.0015246616676449776, -0.0032279908191412687, -0.008037027902901173, 0.02769104205071926, 0.010500377044081688, -0.02719692885875702, 0.030706170946359634, -0.04007217288017273, 0.0011695814318954945, 0.03720434010028839, -0.002294556237757206, -0.003473555203527212, 0.020276742056012154, 0.015358876436948776, 0.01702476106584072, -0.018513323739171028, 0.004043832886964083, -0.03511986508965492, -0.020496411249041557, 0.053138237446546555, -0.007342963945120573, -0.023654505610466003, 0.022258929908275604, 0.018877357244491577, -0.014301384799182415, 0.032174430787563324, 0.014290476217865944, -0.00023768097162246704, 0.010203618556261063, 0.03070754185318947, 0.006001991685479879, -0.008388231508433819, -0.00914974045008421, -0.013377473689615726, -0.00592392310500145, -0.01647578738629818, -0.02754826657474041, -0.019640179350972176, 0.00279181357473135, 0.009080498479306698, -0.016938455402851105, 0.0408211424946785, 0.02573174610733986, -0.009105861186981201, 0.0030024689622223377, 0.005855402909219265, -0.0554332360625267, 0.0019269995391368866, 0.006312877405434847, 0.004569372162222862, -0.01110940519720316, -0.0058289337903261185, 0.01479108352214098, 0.0023937963414937258, 0.005088614299893379, -0.008951164782047272, -0.0038292480167001486, -0.023096829652786255, 0.010434160009026527, -0.012729829177260399, -0.015001608058810234, 0.00523370923474431, 0.004083175677806139, 0.015189317986369133, 0.005563053768128157, 0.012423846870660782, -0.00020647665951400995, -0.035188715904951096, 0.012431097216904163, 0.004561601672321558, -0.019265543669462204, 0.002673952840268612, 0.002908940427005291, 0.004276268184185028, -0.006648470647633076, 0.0007002525962889194, 0.0014729485847055912, -0.028372254222631454, -0.029278311878442764, 0.0031849141232669353, 0.016906214877963066, 0.016604969277977943, -0.013929101638495922, -0.0014247659128159285, 0.010737328790128231, -0.0016435900470241904, -0.02008099853992462, 0.014671876095235348, 0.00470210425555706, -0.010117990896105766, 0.008408721536397934, -0.004746315069496632, 0.008516757749021053, 0.0017928089946508408, 0.006846474017947912, -0.009539371356368065, -0.007575996220111847, 0.03713412210345268, 0.006317492574453354, -0.0001664920710027218, 0.0660766139626503, 0.0002056802622973919, 0.019890159368515015, -0.011174693703651428, 0.016472525894641876, 0.012672973796725273, -0.02170923352241516, -0.009242013096809387, -0.010564147494733334, 0.006078347563743591, 0.007504061795771122, 0.00024373875930905342, -0.011612316593527794, -0.031045492738485336, 0.00040892139077186584, -0.011468254029750824, 0.0019334598910063505, 0.030206451192498207, 0.010028799995779991, -0.00468288641422987, -0.014172186143696308, -0.00010688928887248039, -0.008611212484538555, 0.011366931721568108, -0.00704721175134182, 0.020289722830057144, 0.006684749387204647, 0.020384641364216805, -0.012965003959834576, -0.013167118653655052, -0.041315868496894836, 0.02067304030060768, -0.027355700731277466, -0.008951378986239433, -0.024779489263892174, 0.017373856157064438, -0.01220688782632351, 0.01742805726826191, 0.029667245224118233, 0.017043782398104668, -0.01342944335192442, -0.00447884202003479, 0.0015879081329330802, -0.003367356490343809, -0.004771226551383734, -0.002219841815531254, 0.005350192077457905, -0.004586066119372845, 0.010229868814349174, 0.0014825770631432533, 0.007484726142138243, -0.025522219017148018, -0.031483881175518036, -0.014178094454109669, 0.009726768359541893, 0.010761892423033714, -0.01515899132937193, 0.013812648132443428, -0.02599034458398819, 0.0017061064718291163, -0.008907411247491837, 0.00007643154822289944, 0.00703332107514143, 0.005834345240145922, -0.030501697212457657, 0.017332496121525764, -0.007231731433421373, -0.0021310884039849043, -0.008095975033938885, 0.015280477702617645, -0.028015287593007088, 0.01137969084084034, 0.014613252133131027, 0.004231520462781191, -0.008784033358097076, -0.033785395324230194, -0.021002523601055145, -0.015495911240577698, -0.020168401300907135, 0.0256322231143713, 0.019452150911092758, -0.002239345107227564, 0.007678330410271883, 0.008745763450860977, 0.04020325839519501, -0.03346739709377289, 0.027494080364704132, 0.03098304383456707, 0.026045668870210648, -0.01294898334890604, 0.009224900975823402, 0.009935736656188965, -0.011887464672327042, 0.003842744743451476, -0.08124363422393799, 0.0003090191166847944, -0.014877383597195148, -0.0004676869139075279, 0.0017739280592650175, 0.010775871574878693, 0.01748732477426529, -0.00023698247969150543, -0.017187301069498062, 0.009608719497919083, 0.01837238110601902, -0.020201850682497025, -0.0016053698491305113, -0.01604214496910572, -0.008222902193665504, -0.009692461229860783, 0.023987306281924248, -0.006396316457539797, 0.01170481089502573, -0.028217177838087082, -0.008091985248029232, -0.036671750247478485, 0.008278487250208855, 0.02320244535803795, -0.005015749484300613, 0.007637188769876957, 0.017254194244742393, -0.015251416712999344, 0.017948104068636894, 0.010005039162933826, -0.0492992028594017, 0.009175969287753105, -0.002234342973679304, -0.0026056936476379633, 0.011794555932283401, 0.0042916759848594666, -0.004441510420292616, -0.01868996024131775, -0.030227728188037872, 0.00592053635045886, -0.019162029027938843, 0.015761641785502434, 0.002893111202865839, -0.010410387068986893, 0.0070112417452037334, 0.017095748335123062, 0.024167949333786964, 0.007923060096800327, 0.025946617126464844, -0.008806897327303886, 0.0244489423930645, -0.01495570782572031, 0.007277011405676603, 0.0172707661986351, -0.00852133147418499, -0.006456500850617886, -0.017630504444241524, 0.017440881580114365, -0.008409497328102589, 0.001971473917365074, -0.020541274920105934, 0.024164363741874695, 0.0161703210324049, 0.008042169734835625, -0.013055313378572464, 0.032896991819143295, 0.03281017020344734, -0.007617566734552383, -0.0021181434858590364, 0.020342212170362473, -0.004627496935427189, -0.005029468797147274, -0.01022179052233696, -0.009990100748836994, -0.021340103819966316, -0.012540945783257484, -0.018199175596237183, -0.00533809931948781, 0.01810702495276928, -0.03155119717121124, 0.00037018023431301117, -0.004644256085157394, -0.01445743814110756, -0.033902741968631744, -0.02320954017341137, -0.03437458723783493, 0.013931335881352425, 0.05087532103061676, 0.01000172644853592, -0.016648808494210243, 0.017633138224482536, 0.023095278069376945, 0.014449686743319035, 0.009887121617794037, -0.005113836377859116, 0.016463275998830795, -0.01337601151317358, -0.012989599257707596, 0.019598137587308884, 0.008027897216379642, -0.030945418402552605, -0.014368988573551178, 0.0004096378106623888, -0.006369392387568951, 0.0076553053222596645, 0.015835842117667198, 0.0012463456951081753, -0.013124560005962849, -0.013590295799076557, 0.0050394535064697266, 0.01969677023589611, 0.0392330065369606, -0.01224195584654808, 0.012049851007759571, 0.01410599984228611, -0.015257008373737335, -0.010542495176196098, 0.012070491909980774, 0.07176949083805084, 0.030369125306606293, -0.002017033752053976, -0.025837261229753494, 0.04691080376505852, -0.020442582666873932, 0.020574718713760376, 0.041312284767627716, -0.02124299854040146, 0.0025072135031223297, 0.013381918892264366, -0.05045747384428978, -0.002752048894762993, 0.01367995236068964, -0.012203415855765343, 0.022554241120815277, -0.00009730271995067596, -0.008015276864171028, 0.00011631008237600327, 0.044298041611909866, 0.03092183917760849, -0.003216814249753952, -0.010178720578551292, -0.016393305733799934, 0.011247435584664345, -0.058225952088832855, -0.004344837740063667, -0.01648971252143383, -0.01679152064025402, 0.007428780198097229, 0.015569692477583885, -0.0029514050111174583, -0.011766169220209122, 0.016022389754652977, 0.016544202342629433, 0.01547687966376543, 0.02285083755850792, -0.007505869027227163, -0.002528994809836149, -0.020964015275239944, 0.007319852244108915, -0.010561801493167877, -0.005504759959876537, 0.017062794417142868, -0.012607218697667122, -0.03231249749660492, 0.023641014471650124, -0.011007817462086678, -0.014932441525161266, -0.03471371904015541, -0.01258264109492302, 0.009906725957989693, 0.011291197501122952, 0.011310931295156479, 0.002768460661172867, 0.02024243399500847, 0.027231523767113686, -0.008113114163279533, -0.0006404779851436615, -0.013367910869419575, -0.03393467515707016, 0.011584374122321606, 0.007460255641490221, 0.001960073597729206, 0.018574325367808342, -0.02113204449415207, -0.009061664342880249, -0.007893807254731655, -0.010217847302556038, -0.0011824739631265402, 0.028443772345781326, 0.01595592126250267, -0.0009909938089549541, -0.0005494474899023771, -0.003816823475062847, -0.00825899001210928, 0.007814636453986168, -0.0013932548463344574, 0.01702636480331421, -0.005654567386955023, -0.007507281843572855, -0.01815984770655632, -0.004959145560860634, -0.004012132063508034, 0.00892989058047533, -0.015761394053697586, -0.03395668417215347, -0.07446500658988953, -0.0011393353343009949, -0.005425662733614445, -0.0008040296961553395, 0.026227490976452827, 0.016340378671884537, -0.020593807101249695, 0.0076935687102377415, 0.013292424380779266, -0.003216950222849846, -0.002514222636818886, 0.024546295404434204, 0.026304541155695915, -0.017254488542675972, 0.01145514752715826, 0.00003392808139324188, -0.015209228731691837, 0.002199500799179077, -0.01512068696320057, -0.026367126032710075, 0.0024229250848293304, 0.07572641223669052, -0.009263304993510246, 0.013372211717069149, -0.01468494813889265, -0.08045676350593567, -0.008712323382496834, 0.02109399065375328, 0.000705295242369175, 0.00438513420522213, 0.002165802288800478, 0.015958838164806366, -0.01399573776870966, 0.00305924192070961, -0.017815906554460526, -0.011865881271660328, 0.021648842841386795, -0.0023451761808246374, 0.01154053583741188, -0.008798930794000626, -0.013792888261377811, -0.0008664196357131004, 0.0066163972951471806, 0.014179276302456856, -0.0035685612820088863, 0.001952141523361206, 0.002409481443464756, -0.012747089378535748, 0.003400838002562523, -0.008870496414601803, 0.013001295737922192, -0.005997272673994303, 0.02195274643599987, 0.004915269557386637, 0.009291695430874825, -0.013153202831745148, -0.025133009999990463, 0.0027682725340127945, -0.0068784449249506, 0.0051232799887657166, -0.010973439551889896, 0.0042734816670417786, 0.0013057575561106205, 0.026413047686219215, -0.011851005256175995, -0.005128086544573307, -0.008568367920815945, 0.047792792320251465, 0.009726408869028091, 0.004463706165552139, -0.020619791001081467, 0.007368642836809158, -0.0055886562913656235, 0.028444763273000717, -0.0114903524518013, 0.005553463473916054, -0.013318209908902645, 0.0018419659463688731, 0.012338103726506233, -0.01023352425545454, 0.004303999710828066, 0.00331320078112185, 0.010791415348649025, 0.026332078501582146, 0.022370031103491783, -0.008159738965332508, 0.009737871587276459, -0.008780205622315407, 0.071144238114357, 0.0023576850071549416, -0.000691002351231873, 0.016305893659591675, 0.007826657965779305, 0.005388341844081879, -0.020865023136138916, -0.0011885856511071324, -0.03153987601399422, -0.04283345490694046, -0.02426019124686718, -0.010749745182693005, -0.018612951040267944, 0.0124352490529418, -0.016075946390628815, -0.014033664017915726, 0.022473156452178955, 0.005794363562017679, -0.04010114073753357, 0.01392647810280323, -0.010481447912752628, 0.02932783216238022, -0.01359802857041359, -0.01659776270389557, -0.016563545912504196, -0.007478778250515461, -0.007070342544466257, 0.025630991905927658, 0.010806849226355553, 0.0037838704884052277, -0.009661152958869934, 0.010952564887702465, 0.002949538640677929, -0.026851732283830643, 0.028587672859430313, 0.00697711668908596, -0.027878470718860626, 0.017890706658363342, -0.018551556393504143, 0.007316307630389929, -0.03853735700249672, 0.012618612498044968, -0.003954008687287569, 0.017941270023584366, 0.0178062804043293, 0.008267667144536972, 0.0008444406557828188, -0.005107221193611622, 0.0005010503809899092, 0.0096643241122365, 0.038331545889377594, -0.00048553175292909145, 0.03712726756930351, -0.00238849688321352, 0.010051639750599861, 0.01409215945750475, -0.04939836263656616, 0.018703851848840714, -0.00853214506059885, -0.022594714537262917, 0.006799930240958929, -0.013912433758378029, -0.0396709218621254, -0.023665163666009903, 0.008609512820839882, 0.007473991252481937, 0.023596487939357758, -0.013029234483838081, -0.022526219487190247, 0.013279790058732033, -0.01713041216135025, -0.004343461710959673, 0.008208094164729118, 0.02944304421544075, 0.00834756251424551, -0.017150351777672768, 0.005493268370628357, -0.005895075388252735, 0.04152986779808998, 0.015913553535938263, -0.01242328155785799, 0.017802778631448746, -0.0014381520450115204, -0.009607665240764618, -0.00571833411231637, -0.0035627498291432858, -0.013835877180099487, -0.0020102565176784992, 0.005760141182690859, 0.011022049002349377, 0.004894207697361708, -0.00793159008026123, 0.011501998640596867, 0.013741057366132736, 0.010022520087659359, 0.03471352905035019, 0.014479946345090866, 0.010457335039973259, 0.004609923344105482, 0.0067284926772117615, -0.0030013835057616234, 0.03365856036543846, -0.0025841002352535725, -0.0424080491065979, -0.019746879115700722, -0.007697809487581253, 0.017693564295768738, 0.0007126843556761742, 0.01706862449645996, 0.019488587975502014, 0.002481348579749465, 0.004637890495359898, 0.029388923197984695, 0.012414958328008652, -0.0005909759784117341, 0.008908778429031372, -0.019474534317851067, -0.02043936401605606, 0.0007717260159552097, -0.016648350283503532, -0.005538127385079861, 0.0043207318522036076, 0.011344739235937595, 0.014388345181941986, -0.005169901065528393, -0.0071904961951076984, -0.009740701876580715, 0.05409874767065048, 0.004583834670484066, 0.0003834497183561325, 0.036834798753261566, 0.002746749669313431, 0.004649846814572811, 0.0015243050875142217, -0.0033315711189061403, 0.01820380613207817, 0.007503415457904339, -0.005712032318115234, 0.012303759343922138, -0.018736686557531357, 0.029888499528169632, -0.020442122593522072, 0.002368302782997489, -0.0037469258531928062, 0.009070176631212234, 0.014916094951331615, 0.039227429777383804, -0.011466164141893387, 0.014013092033565044, 0.00820749718695879, 0.0053004552610218525, 0.007995665073394775, 0.01663578487932682, -0.006368771195411682, -0.02164679579436779, 0.010073374956846237, 0.009366939775645733, -0.02872970700263977, 0.0016565467230975628, 0.01841454766690731, -0.01408800482749939, 0.007205153815448284, 0.006972751580178738, -0.007885194383561611, 0.00408615916967392, -0.0032741562463343143, 0.00462018046528101, -0.018468575552105904, -0.002072746865451336, 0.008373047225177288, 0.017848404124379158, -0.010247175581753254, 0.0010271994397044182, 0.02501264400780201, -0.00006440794095396996, -0.007875697687268257, 0.00022882362827658653, -0.004310822580009699, 0.041601087898015976, 0.01089761033654213, 0.014836829155683517, 0.026530034840106964, 0.0003952193073928356, -0.014602980576455593, 0.014385180547833443, -0.010339811444282532, -0.007180776912719011, -0.008391736075282097, -0.0063651492819190025, 0.009399086236953735, -0.03979528695344925, -0.014993070624768734, -0.0054193646647036076, 0.02532307803630829, -0.010791415348649025, 0.01227677334100008, 0.01891210488975048, 0.002515869215130806, -0.005923249293118715, 0.011647763662040234, -0.0073767248541116714, 0.013009046204388142 ]
[ -0.22830070555210114, 0.004900046158581972, 0.3845076262950897, -0.20923836529254913, -0.25251147150993347, 0.13397282361984253, 0.2974933385848999, -0.7713146209716797, 0.0026585084851831198, -0.6971951723098755, -0.02235712669789791, 0.010861663147807121, -0.688557505607605, 0.16397228837013245, -0.17041084170341492, 0.6517660021781921, 0.38851457834243774, 0.49978598952293396, -0.23310145735740662, -0.47275295853614807, -0.1310047060251236, -0.26395389437675476, 0.6542657613754272, -0.1718502938747406, -0.0070023313164711, -0.0009139618487097323, 0.6499831080436707, 0.14100615680217743, 0.5069109201431274, -0.3606092929840088, -0.26029160618782043, 0.5511263608932495, 0.26046133041381836, -0.34453096985816956, -0.29090121388435364, 0.05386645719408989, -0.10962587594985962, -0.0758710652589798, 0.33969148993492126, 0.11611300706863403, -0.16069568693637848, -0.26477622985839844, -0.5186290740966797, 0.5995726585388184, -0.22345377504825592, -0.06539308279752731, -1.6138317584991455, 0.9205109477043152, -0.35263049602508545, -0.06897354871034622, -0.24737805128097534, 0.23779574036598206, 0.7388889789581299, -0.029351092875003815, 0.3528486490249634, 0.12264679372310638, -0.9364158511161804, -0.13582995533943176, 0.6269277334213257, -0.834846556186676, -0.026594234630465508, -0.16729336977005005, 0.22429323196411133, 0.05559569224715233, -0.13135330379009247, 0.47113221883773804, 0.23538914322853088, -0.26015564799308777, -0.45756226778030396, 0.1297932118177414, 0.49537393450737, -0.27156007289886475, -0.09140556305646896, -0.11557602882385254, -0.1454651653766632, -0.1272151917219162, -0.5704969763755798, -0.1694875955581665, 0.11140194535255432, 0.33457306027412415, -0.29934391379356384, 0.1532985121011734, 0.2659635841846466, 0.0955241248011589, 0.3439641296863556, 0.5042431950569153, -0.3677189350128174, 0.4338812530040741, -0.8978714346885681, 0.06902746111154556, -0.37965792417526245, -0.25149646401405334, 0.5225096940994263, 0.4523259997367859, 0.5861018300056458, 0.5719979405403137, -0.10127110034227371, 0.004655805882066488, 0.09174065291881561, 0.5777568221092224, -0.2965039610862732, 0.014980780892074108, -0.05662260577082634, -0.4730285704135895, -0.6164806485176086, -0.3524034917354584, -0.2342912256717682, -0.919551432132721, -0.3853270411491394, 0.06253377348184586, -0.778675377368927, -0.15591953694820404, -0.3160765469074249, -0.1496121883392334, 0.010059161111712456, 0.22621773183345795, 0.15863128006458282, -0.2932562828063965, -0.08722883462905884, 0.4029417634010315, -0.3073716461658478, 1.3694837093353271, -0.5117282867431641, 0.4304654598236084, -0.059297624975442886, -0.0260627418756485, -0.06802887469530106, -0.30392155051231384, -0.07859934866428375, 0.4654863774776459, 0.48278167843818665, 0.945690393447876, -0.009148716926574707, 0.08855993300676346, -0.05918178707361221, -0.4213799238204956, 0.15339788794517517, 0.12099561095237732, -0.06997387111186981, 0.2261778563261032, -0.32908210158348083, -0.261437326669693, -0.5673978924751282, -0.055292680859565735, 0.1807842254638672, -0.0728725790977478, -0.59151291847229, 0.17232884466648102, -0.09523003548383713, -0.21937914192676544, 0.006441407836973667, -0.20807701349258423, -0.6195552349090576, 0.2270677536725998, -0.270521342754364, 0.5874148011207581, -0.20537681877613068, -0.24368144571781158, 0.4026060104370117, 0.11498592793941498, 0.18774010241031647, 0.0502760075032711, -0.15302948653697968, 0.04664077237248421, 0.015103223733603954, -0.09547490626573563, 0.4884912073612213, 0.5989308953285217, -0.22887782752513885, -0.06209522858262062, -0.25820696353912354, -0.6866945624351501, 0.3873244524002075, -0.2594136595726013, -0.06919905543327332, -0.401984304189682, 0.1974383443593979, -0.43935626745224, 0.11887434870004654, -0.058310382068157196, -0.8405593633651733, -0.5988233089447021, -0.3394728899002075, -0.39646685123443604, 0.3019038736820221, 0.394006609916687, 0.539556622505188, 0.22664162516593933, -0.10839756578207016, 0.2038273960351944, 0.12918776273727417, -0.3087720274925232, 0.44083476066589355, -0.3057880997657776, 1.888028621673584, -0.21923579275608063, -0.14184491336345673, 1.1348686218261719, 0.4935359060764313, 0.4653771221637726, -0.0870228111743927, -0.47361207008361816, 0.7881858944892883, -0.3675937056541443, 0.03381345793604851, 0.034722279757261276, -0.4407906234264374, 0.1209629476070404, -0.06088392809033394, -0.09709102660417557, 0.4252857565879822, -0.22647877037525177, 0.04724610224366188, -0.15577737987041473, 0.5854931473731995, -0.3810843229293823, 0.4081779420375824, -0.17782914638519287, -0.3196813762187958, 0.12668442726135254, 0.6671094298362732, -0.6449282169342041, 0.5271078944206238, 0.6602386832237244, -0.5905040502548218, 0.47337645292282104, 0.4302960932254791, 0.1495802402496338, 0.8777958750724792, 0.05640215799212456, 0.17503464221954346, -0.47343817353248596, 0.37223348021507263, -0.3204716742038727, -0.28637364506721497, 0.016372419893741608, 0.3262523114681244, 0.1402178406715393, -0.20397832989692688, -0.2683524787425995, -0.11574681103229523, 0.9880877137184143, -0.32409873604774475, -0.10345631837844849, 0.32647472620010376, -0.6620474457740784, 0.34169265627861023, 0.2061028778553009, -0.9355084896087646, -0.20183885097503662, 0.055757276713848114, 0.23395878076553345, 0.2571963369846344, -0.5395204424858093, 0.4871426820755005, 0.23988351225852966, 0.09959685802459717, -0.5463733077049255, -0.10425461083650589, -0.005122229922562838, 0.10765164345502853, 0.08976072072982788, -0.25494852662086487, 0.2971848249435425, 0.20067425072193146, -0.3785512447357178, -0.2700149118900299, -0.4953465461730957, 1.3221853971481323, 0.5969544649124146, 1.0565307140350342, -0.49372249841690063, -0.448331743478775, -0.0318666435778141, 0.24634301662445068, -0.4328283369541168, -0.020091993734240532, 0.16916373372077942, -0.332514226436615, -0.45583927631378174, -0.25171300768852234, 0.4594660699367523, 0.8294206857681274, 0.19390077888965607, -0.18346086144447327, 0.13846594095230103, -0.2278977632522583, -0.19147993624210358, -0.3666679561138153, -0.3139893114566803, -0.22646649181842804, -0.020970340818166733, -0.25380054116249084, -0.1522243767976761, -0.1537294089794159, 0.41370460391044617, -0.1607033908367157, 0.5724155902862549, 0.5190109610557556, 0.31979361176490784, -0.4730215072631836, 0.4707689583301544, -0.34326595067977905, -0.4281207025051117, 0.20512810349464417, 0.15181340277194977, -0.5356493592262268, 0.5912537574768066, -5.7748494148254395, 0.11641844362020493, -0.027653098106384277, -0.23311899602413177, 0.15276053547859192, -0.28332290053367615, 0.20928719639778137, -0.1380571573972702, 0.33475667238235474, -0.0691877081990242, 0.23543229699134827, 0.5184900760650635, -0.00651062885299325, 0.08611129969358444, -0.4058482050895691, -0.597399115562439, -0.5502650737762451, 0.16603712737560272, 0.6729852557182312, 0.17465193569660187, 0.0019037321908399463, -0.21326544880867004, -0.16260674595832825, 0.45659440755844116, -0.05120844766497612, -0.055636122822761536, -1.0140210390090942, 0.13728153705596924, -0.1979355812072754, -0.3341910243034363, -0.038760121911764145, -0.44603297114372253, -0.16919520497322083, -0.3575589656829834, 0.24508854746818542, -0.21504682302474976, 0.1537601500749588, 0.17193815112113953, 0.024837639182806015, -0.6088011264801025, 0.45495834946632385, 0.12863270938396454, -0.4255980849266052, -0.20092110335826874, 0.40424224734306335, -0.3802136778831482, -0.4316070079803467, 0.2236471325159073, -0.33088475465774536, 0.4351133704185486, -0.18912695348262787, -0.2848483920097351, 0.3615039587020874, 0.4514924883842468, 0.5337564945220947, 0.2590866982936859, -0.09780193865299225, 0.2498595118522644, -0.30628180503845215, 0.10680217295885086, -0.21274372935295105, -0.28665515780448914, -0.5759944915771484, -0.9199371933937073, -0.15724915266036987, 0.014046183787286282, -0.8833418488502502, 0.14058925211429596, 0.36907076835632324, -0.5704150795936584, -0.34811699390411377, 0.26322418451309204, 0.37743887305259705, -0.854906439781189, 0.9452718496322632, -0.09123967587947845, 0.07171759754419327, -0.07514272630214691, -0.13782621920108795, 0.12635983526706696, -0.44834259152412415, -0.08564792573451996, -0.030763065442442894, -0.06348360329866409, 0.15151624381542206, -0.6419936418533325, -0.15671391785144806, -0.13937819004058838, 0.10518136620521545, 0.39089834690093994, 0.15113666653633118, -0.5755519270896912, 0.20521891117095947, 0.5827791690826416, -0.13158881664276123, 0.20051328837871552, 0.3101985454559326, 0.3975926339626312, 0.5957732796669006, 0.029316524043679237, 1.0719327926635742, -0.44426146149635315, -0.6455995440483093, -0.6016823053359985, 0.17447246611118317, 0.21444466710090637, -0.45951324701309204, 0.5329614877700806, 0.7296669483184814, -0.1993468701839447, -0.02873450145125389, -0.07982759177684784, -0.4191536605358124, -0.15757672488689423, 0.989467442035675, -0.2706080675125122, -0.19781337678432465, -0.07064466178417206, 0.5444939136505127, -0.059575390070676804, 0.09511619061231613, 0.29120856523513794, -0.37770017981529236, 0.683192253112793, 0.09946750849485397, 0.041361454874277115, 0.2635055482387543, 0.5312665700912476, -0.9567278027534485, -0.2511942386627197, 0.53944993019104, 0.029535094276070595, -0.3326720595359802, 0.19601920247077942, 0.47059735655784607, -0.4923166334629059, -0.3312165141105652, 0.4703153073787689, 0.6872374415397644, -0.6869038939476013, 0.41331422328948975, -0.3328644931316376, -0.25550663471221924, 0.29392245411872864, -0.11495048552751541, 0.22503411769866943, 0.24321694672107697, 0.46161651611328125, -0.6715156435966492, -0.5236549973487854, 0.3245387375354767, -0.43469128012657166, -0.05448095500469208, 0.09874796122312546, -0.2622050940990448, 0.4647742807865143, 0.4728449583053589, 0.29741305112838745, 0.14272058010101318, -0.7431983947753906, 0.21836265921592712, 0.30326056480407715, -0.7206026315689087, 0.21137553453445435, -0.3064846694469452, -0.2946050465106964, 0.1381072849035263, -0.14193229377269745, -0.007528921589255333, 0.2625519633293152, -0.4080125093460083, -0.17005158960819244, 0.10512936115264893, -0.4994264245033264, 0.01969660446047783, -0.24033795297145844, -0.403679758310318, 0.07724650204181671, 0.03713114932179451, 0.6629226803779602, 0.2512141764163971, -0.23570311069488525, -0.18495303392410278, 0.0002792036102619022, 0.3874354064464569, 0.40251097083091736, 0.08515729010105133, -0.22874219715595245, -0.10772654414176941, -0.7283496856689453, 0.06373590230941772, 0.2307354211807251, 0.27398189902305603, 0.19759194552898407, 0.3041377365589142, 0.011197096668183804, 0.3384266495704651, 0.3911074995994568, -0.0023967407178133726, -0.7522837519645691, 0.010436923243105412, 0.6381970643997192, -0.2986829876899719, 0.3676551580429077, 0.6656820178031921, -0.11980937421321869, -0.24747222661972046, 0.08832743018865585, 0.052513863891363144, 0.012150765396654606, -0.10669263452291489, -0.6593747735023499, 0.023178119212388992, -0.05571700632572174, 0.05591578781604767, -0.21189917623996735, 0.46634769439697266, -0.5848467946052551, -0.31646502017974854, 0.32282689213752747, -0.18186235427856445, -0.14118924736976624, 0.1699402779340744, -0.15718740224838257, -0.7088643908500671, -0.08020186424255371, 0.14709043502807617, -0.7131227254867554, 0.4356541633605957, -0.10963036119937897, 0.3854215443134308, 0.14285020530223846, 0.343656450510025, 0.3966365456581116, -0.515399694442749, -0.5795459151268005, 0.02328854613006115, 0.06366554647684097, 0.06743162125349045, 0.5800575613975525, 0.41295790672302246, 0.4544934034347534, -0.30824539065361023, -0.17544108629226685, -0.37726840376853943, 0.29830294847488403, -0.00949083548039198, -0.34232980012893677, -0.2107747346162796, 0.04347548633813858, 0.24721956253051758, -0.40739089250564575, 0.2810192406177521, 0.6770572066307068, 1.2879981994628906, -0.1673806607723236, 0.027723107486963272, -0.5325608849525452, -0.3447311520576477, 0.08568587899208069, -0.34037548303604126, 0.017734089866280556, -0.08463731408119202, 0.10293770581483841, 0.16217924654483795, 0.01573443040251732, -0.2942458391189575, -0.9461566805839539, 0.5510735511779785, -0.1771024465560913, -0.2900789678096771, 0.03428895026445389, 0.40458446741104126, 0.08725367486476898, -0.6134718060493469, 0.3658705949783325, 0.0855860561132431, 0.3889617621898651, -0.16131851077079773, 0.35258999466896057, -0.2509191036224365, -0.17900291085243225, 0.4526025354862213, -0.45361486077308655, 0.04803330823779106, -0.6397058963775635, -0.15747451782226562, -0.5435208678245544, 0.2307949960231781, -0.2864701449871063, -0.17522473633289337, -0.15171392261981964, -0.8389238715171814, -0.5662806630134583, -0.155217707157135, 0.012985073029994965, 0.012689805589616299, 0.20722877979278564, -0.06287457793951035, 0.2517794370651245, -0.3251854479312897, 0.6147173643112183, 0.40621286630630493, -0.4369677007198334, 0.01027721632272005, 0.012717987410724163, 0.17187732458114624, 0.11093752831220627, -0.22335146367549896, -0.06828387081623077, -0.23715239763259888, -0.17148178815841675, 0.5537091493606567, -0.12010487169027328, -0.5844756960868835, 0.2935199439525604, -0.031261127442121506, -0.26970604062080383, 0.2838442623615265, 0.1645967960357666, 0.3438917100429535, 0.6635873317718506, 0.3841725289821625, 0.2838348150253296, -0.3089013993740082, 0.7279677987098694, 0.4243457615375519, -0.05520398169755936, 0.07235317677259445, 0.6147449612617493, 0.613717794418335, 0.10543593019247055, -0.0832352340221405, 0.5788472890853882, 0.5354388356208801, -0.0065587242133915424, 0.17382879555225372, 0.036781586706638336, 0.07233374565839767, 0.38693976402282715, 0.3399601876735687, 0.5215593576431274, -0.386519193649292, -0.18682943284511566, 0.09026116877794266, 0.39820873737335205, -0.09608708322048187, -0.12616080045700073, -0.09545078873634338, 0.5790424942970276, 0.547187864780426, 0.09384088963270187, -0.35854920744895935, 0.8303571343421936, -0.6734943985939026, 0.23534250259399414, 0.49682778120040894, -0.504247784614563, -0.817033052444458, 0.38494595885276794, 0.03126432001590729, 0.03872416168451309, 0.016442805528640747, 0.9500051736831665, -0.012142753228545189, -0.09916900098323822, 0.2536332905292511, -0.008663825690746307, 0.4111606478691101, 0.02106548100709915, -0.19411052763462067, 0.19248096644878387, -0.2603854238986969, 0.1268017739057541, -0.1209990605711937, -0.09011605381965637, 0.018116025254130363, -0.35490351915359497, 0.013301484286785126, 0.18456482887268066, -0.40817680954933167, 0.43363261222839355, -0.37821170687675476, -0.5823352932929993, -0.39101502299308777, -0.4792291522026062, -0.04168378934264183, -0.005127837415784597, 0.1087111085653305, 0.10414944589138031, -0.01765366457402706, -0.9055313467979431, 0.11158071458339691, -0.1623883843421936, 0.21482641994953156, -0.07418326288461685, 0.1840909719467163, 0.1332464963197708, 0.5126973390579224, 0.7538883090019226, -0.15740007162094116, 0.39407065510749817, -0.046364475041627884, 0.5177781581878662, -0.7641524076461792, 0.1769307255744934, -0.4584241509437561, -0.3106314241886139, -0.11413737386465073, -0.352672815322876, 0.8920037150382996, 0.6357139348983765, -0.4422110915184021, 0.003372433129698038, 0.20249544084072113, 0.7430399060249329, 0.10930607467889786, -0.4562476575374603, -0.12276899814605713, -0.3993457555770874, -0.19015805423259735, -0.2936636805534363, 0.666354775428772, 0.10410161316394806, -0.29657208919525146, -0.12886695563793182, 0.3260589838027954, 0.04283475503325462, -0.7991846799850464, 0.3461138904094696, -0.4955716133117676, -0.1966553032398224, -0.4640112519264221, -0.030197512358427048, -0.6840792894363403, 0.3296850621700287, -0.40640366077423096, -0.3504283130168915, 0.001856509712524712, -0.027354098856449127, -0.12021007388830185, -0.283927857875824, -0.03381093218922615, 0.1899111419916153, -0.15680180490016937, 0.28868111968040466, -0.18799500167369843, -0.9689506888389587, -0.3862738609313965, 0.04853583127260208, 0.13463915884494781, -0.15146471560001373, -0.10621053725481033, -0.22213506698608398, 0.29746097326278687, 0.3025410771369934, 0.2051302194595337, -0.5012689232826233, -0.04854751378297806, 0.14224623143672943 ]
The Hippo–YAP pathway is an emerging signalling cascade involved in the regulation of stem cell activity and organ size. To identify components of this pathway, we performed an RNAi-based kinome screen in human cells. Our screen identified several kinases not previously associated with Hippo signalling that control multiple cellular processes. One of the hits, LKB1, is a common tumour suppressor whose mechanism of action is only partially understood. We demonstrate that LKB1 acts through its substrates of the microtubule affinity-regulating kinase family to regulate the localization of the polarity determinant Scribble and the activity of the core Hippo kinases. Our data also indicate that YAP is functionally important for the tumour suppressive effects of LKB1. Our results identify a signalling axis that links YAP activation with LKB1 mutations, and have implications for the treatment of LKB1-mutant human malignancies. In addition, our findings provide insight into upstream signals of the Hippo–YAP signalling cascade.
[ -0.011819034814834595, 0.008518693037331104, -0.007052946835756302, 0.02561112493276596, 0.0023086965084075928, 0.008417877368628979, 0.011334609240293503, 0.022655218839645386, -0.011844262480735779, 0.0018065497279167175, -0.026007112115621567, 0.0047797998413443565, 0.004102687351405621, 0.028280917555093765, -0.0053336359560489655, 0.030126888304948807, -0.005607258062809706, 0.012149324640631676, 0.01190321147441864, -0.00735863670706749, 0.005264117382466793, 0.001596637419424951, 0.009898321703076363, -0.04099574312567711, 0.04329308122396469, -0.0026633148081600666, -0.010609138756990433, -0.0010463395155966282, -0.0038892803713679314, 0.00500101875513792, 0.0066825575195252895, 0.012463938444852829, 0.01456461101770401, -0.006090272217988968, 0.005770319607108831, 0.005348760634660721, -0.007654138840734959, 0.012727314606308937, 0.008781777694821358, -0.004144292324781418, -0.02348175086081028, -0.008793501183390617, -0.0002728821709752083, 0.007807163521647453, -0.008969605900347233, 0.013524617999792099, -0.004029515665024519, 0.007100831717252731, -0.014221507124602795, 0.012709708884358406, -0.014212936162948608, -0.007466522976756096, -0.00710282102227211, 0.009037166833877563, -0.006036099977791309, 0.010925378650426865, 0.01695242151618004, 0.0011400170624256134, -0.023810114711523056, -0.005117838736623526, 0.011682555079460144, -0.027052724733948708, 0.024753378704190254, -0.033489424735307693, -0.013718949630856514, -0.06703344732522964, 0.01455916091799736, 0.02288280427455902, -0.010693199001252651, -0.01358819380402565, 0.0061991456896066666, 0.006821857765316963, -0.005524125881493092, -0.039022862911224365, 0.005571981891989708, -0.0031078725587576628, -0.00518874591216445, 0.0013269712217152119, 0.004809112288057804, 0.022295914590358734, 0.001044081524014473, -0.014970829710364342, 0.013777286745607853, 0.016103671863675117, -0.021949324756860733, 0.0023957430385053158, -0.021737858653068542, 0.00020578928524628282, -0.010693138465285301, -0.03610682487487793, -0.011669943109154701, -0.008208271116018295, -0.014249566942453384, -0.005950001068413258, -0.0035458537749946117, -0.004824160132557154, -0.023667793720960617, -0.0032564778812229633, 0.029567673802375793, -0.01679932326078415, -0.01359512098133564, 0.023336485028266907, 0.018282927572727203, -0.008812760934233665, 0.01537340134382248, 0.011316809803247452, -0.018419824540615082, -0.008318579755723476, 0.01475827768445015, 0.008838987909257412, -0.013005994260311127, 0.01346430741250515, 0.004451089072972536, -0.01076626405119896, -0.00059733004309237, -0.007404567673802376, -0.017496416345238686, 0.012475733645260334, 0.007561728358268738, -0.011299818754196167, 0.01393862348049879, -0.0006776689551770687, 0.003459098283201456, 0.003923078067600727, 0.007731540594249964, -0.006556896958500147, -0.0015492719830945134, 0.02317674458026886, -0.007103656884282827, -0.0003907752688974142, -0.00970529206097126, 0.008917596191167831, 0.018229667097330093, -0.009359324350953102, -0.0008000789675861597, -0.007737342268228531, -0.017521224915981293, -0.004408263601362705, -0.01734299212694168, -0.0042198128066957, 0.00035279104486107826, 0.006252054590731859, 0.011161630973219872, 0.01507839560508728, 0.028494063764810562, 0.009596310555934906, 0.0004917988553643227, 0.00015814648941159248, -0.00027255224995315075, -0.006013660691678524, -0.027384299784898758, 0.015893785282969475, 0.0023458492942154408, -0.019832801073789597, 0.0019235508516430855, 0.03438496217131615, -0.036280691623687744, -0.018394744023680687, -0.0027749373111873865, 0.009805300273001194, -0.012394201010465622, -0.019070472568273544, -0.002089767251163721, 0.008939690887928009, 0.015554260462522507, -0.0055731371976435184, 0.017800727859139442, -0.008768653497099876, -0.002650369657203555, 0.004394725430756807, -0.024775655940175056, 0.03559646010398865, -0.0355474129319191, 0.0043830908834934235, -0.005420980043709278, -0.004344434477388859, -0.016873016953468323, 0.008194107562303543, -0.0024251339491456747, 0.06687416136264801, 0.004357059486210346, 0.014046719297766685, 0.008442872203886509, -0.0027390727773308754, -0.006163385696709156, -0.007635087706148624, -0.023521415889263153, -0.001365831820294261, -0.005867375992238522, 0.0023309316020458937, -0.029972169548273087, -0.016686003655195236, -0.0029347590170800686, 0.013354008086025715, -0.031100202351808548, 0.0023047965951263905, 0.006560806650668383, -0.002748693572357297, -0.010283604264259338, 0.015552541241049767, 0.009997839108109474, -0.016095438972115517, 0.0335109680891037, -0.02849142625927925, -0.017029721289873123, 0.0004104145336896181, -0.0010731788352131844, -0.027970366179943085, -0.005615502595901489, 0.013300875201821327, 0.010018778964877129, 0.003648014971986413, -0.01077068131417036, -0.004502842202782631, -0.015100965276360512, 0.005350129213184118, -0.010995237156748772, 0.011700449511408806, 0.007518439553678036, -0.01364673301577568, -0.003917386289685965, 0.002170807681977749, 0.0146935461089015, 0.012154601514339447, 0.026481952518224716, -0.03129175305366516, -0.004862464964389801, 0.013894574716687202, -0.027458811178803444, 0.01939983107149601, -0.019803626462817192, 0.003854666370898485, -0.013434311375021935, -0.024301545694470406, 0.04569486528635025, -0.014053009450435638, 0.01325850561261177, -0.0343959704041481, 0.006165679078549147, -0.005976756103336811, 0.004349744878709316, -0.0076311128214001656, 0.03655274212360382, -0.006878132466226816, -0.0063019851222634315, -0.012309761717915535, 0.012431805953383446, 0.020585890859365463, -0.00043051945976912975, -0.011399105191230774, 0.007280486635863781, -0.002668038010597229, 0.0068458067253232, -0.001414264552295208, -0.002300975378602743, -0.0384092703461647, -0.02939535491168499, -0.010579111985862255, 0.02377822995185852, -0.05360845476388931, -0.007952332496643066, 0.00551967415958643, 0.007958391681313515, -0.008258406072854996, 0.015677962452173233, -0.0318031907081604, 0.008095507510006428, 0.02597297728061676, -0.0023488933220505714, -0.008808834478259087, 0.010637801140546799, -0.010906354524195194, -0.0027577264700084925, -0.08129353821277618, -0.010667598806321621, -0.012326028198003769, 0.003907340578734875, 0.011056097224354744, -0.0013184582348912954, -0.019744550809264183, 0.027322467416524887, -0.009823478758335114, -0.0007671124767512083, 0.008204298093914986, 0.0007508250419050455, -0.005253105890005827, -0.0012702200328931212, 0.021778075024485588, -0.011334671638906002, 0.014317445456981659, 0.005418010987341404, 0.020683005452156067, -0.00741365784779191, 0.0065032849088311195, 0.006136435549706221, -0.007897015661001205, 0.007754832040518522, -0.006645135581493378, 0.0023740590550005436, 0.015613571740686893, -0.011595398187637329, -0.00473432382568717, 0.005023902282118797, -0.019610702991485596, -0.006426435895264149, -0.03186811879277229, -0.0036381655372679234, -0.003194258315488696, -0.009665105491876602, 0.005861957091838121, 0.017658814787864685, -0.030548620969057083, 0.0452275350689888, -0.02364340052008629, 0.013351337984204292, 0.004879665561020374, 0.0003448671195656061, 0.0006518930895254016, 0.01394573412835598, -0.012032339349389076, 0.004556416999548674, 0.015640731900930405, -0.011016570031642914, 0.0233570896089077, -0.005375046748667955, -0.006328699644654989, 0.017681609839200974, -0.014147935435175896, -0.00742711964994669, -0.023959264159202576, 0.004821351729333401, -0.014487501233816147, -0.007432452403008938, -0.007778584025800228, -0.009095834568142891, 0.0036502196453511715, 0.01320851594209671, -0.0036616437137126923, 0.0011521417181938887, 0.014960859902203083, 0.0012469084467738867, -0.0074524651281535625, 0.009562804363667965, -0.017034394666552544, -0.014268887229263783, -0.019752152264118195, -0.004636088386178017, -0.008377362042665482, -0.014045322313904762, -0.012002728879451752, 0.001804016763344407, 0.02271072007715702, -0.02379184029996395, -0.017287541180849075, 0.023022979497909546, -0.02351125329732895, -0.016333304345607758, -0.002506136428564787, 0.009182069450616837, 0.00752378860488534, 0.03488148748874664, 0.015921421349048615, -0.01262849010527134, 0.01978207379579544, 0.015702644363045692, 0.011669733561575413, 0.010692201554775238, -0.006115788593888283, -0.028903154656291008, 0.004739763215184212, -0.006241693161427975, 0.00892697274684906, 0.007713706232607365, -0.02225331775844097, 0.007901688106358051, 0.011614746414124966, -0.011191083118319511, 0.010227153077721596, 0.01368806604295969, 0.001306201214902103, -0.004368328955024481, -0.008985287509858608, 0.00469123013317585, -0.0007897568866610527, 0.011352881789207458, -0.006343850865960121, 0.012100685387849808, 0.013356943614780903, -0.018769660964608192, -0.009101160801947117, -0.011883387342095375, 0.07206577807664871, -0.0024577397853136063, -0.00010685750748962164, -0.01315770298242569, 0.03229504078626633, -0.021080512553453445, -0.0013320008292794228, 0.020943399518728256, 0.0010603417176753283, 0.00030017318204045296, 0.012032566592097282, -0.024992965161800385, -0.015232248231768608, 0.011090642772614956, -0.009152159094810486, 0.028621014207601547, -0.03584261238574982, 0.01472924742847681, -0.012424697168171406, -0.013815552927553654, -0.015582002699375153, 0.009211176075041294, 0.001371185528114438, -0.016050800681114197, -0.0017203036695718765, -0.06865832954645157, 0.022151894867420197, -0.014065805822610855, -0.008660056628286839, 0.009761936962604523, -0.019907744601368904, -0.020650513470172882, -0.009297363460063934, 0.020364299416542053, -0.006446019746363163, 0.03204840421676636, 0.05172551050782204, -0.012268985621631145, 0.018780343234539032, 0.0013054593000561, -0.008475154638290405, -0.013829096220433712, -0.018182048574090004, 0.00878982711583376, 0.00926293432712555, -0.013541298918426037, -0.019851552322506905, -0.005606521852314472, -0.014643311500549316, -0.0007171833422034979, 0.0006243463139981031, 0.0007390680257230997, 0.00667430367320776, -0.0010904897935688496, -0.016186047345399857, 0.019190223887562752, 0.02085842937231064, -0.008930488489568233, -0.021499354392290115, -0.008744430728256702, -0.03168964013457298, -0.01606421172618866, 0.00974099338054657, 0.00034960644552484155, 0.009650231339037418, 0.003235486103221774, -0.003730473108589649, -0.011768912896513939, 0.007867776788771152, 0.006911034695804119, 0.015197400003671646, -0.0018640542402863503, 0.006222656928002834, -0.000475533539429307, -0.02511141635477543, -0.0005088631296530366, 0.003674960695207119, -0.00039054639637470245, 0.0093507319688797, 0.0017764174845069647, 0.0006245018448680639, 0.022327667102217674, -0.0037264451384544373, -0.009174465201795101, 0.014689270406961441, 0.017795510590076447, -0.022596199065446854, -0.07495444267988205, -0.04214399307966232, -0.0017015819903463125, -0.0006704963743686676, 0.0036617377772927284, 0.0005588933127000928, -0.008177189156413078, -0.021777767688035965, -0.00724197831004858, -0.005275007802993059, -0.017883747816085815, 0.013312803581357002, -0.01103148702532053, 0.019862912595272064, 0.009945529513061047, 0.012166623957455158, -0.010596023872494698, 0.0016722712898626924, -0.01429298147559166, -0.02719194069504738, 0.014157217927277088, 0.022661935538053513, 0.011778433807194233, 0.0007139451336115599, -0.007309805601835251, -0.08086884021759033, -0.001732556615024805, -0.00009653373854234815, -0.019984738901257515, 0.010829008184373379, -0.02278711088001728, 0.000515444902703166, -0.02116474136710167, -0.02716141939163208, -0.01466442085802555, 0.015670370310544968, 0.00880787055939436, -0.011317169293761253, 0.011219790205359459, 0.012374009005725384, -0.014490962028503418, 0.020045138895511627, 0.010706815868616104, 0.00968463346362114, 0.004110289737582207, -0.0059554968029260635, 0.013223723508417606, -0.00901617668569088, 0.0024570953100919724, -0.009312031790614128, -0.005392185412347317, -0.011663185432553291, 0.018447445705533028, -0.006308367475867271, -0.005144190043210983, -0.0116029167547822, -0.004470849875360727, -0.0017261561006307602, -0.009108735248446465, -0.019061462953686714, -0.01538311131298542, -0.008293669670820236, -0.004986217711120844, -0.017262794077396393, -0.006733800750225782, 0.00123878032900393, -0.012583006173372269, -0.0007804739288985729, -0.004703977610915899, -0.003216313198208809, -0.0071348762139678, 0.0034592750016599894, -0.00451792124658823, 0.002442085649818182, 0.008489941246807575, 0.0031566526740789413, 0.019876690581440926, 0.012760834768414497, 0.0034526819363236427, 0.009317636489868164, 0.008563537150621414, -0.0037658023647964, 0.023587146773934364, 0.004925258457660675, 0.009602198377251625, -0.008504888042807579, 0.009795518592000008, 0.0013792553218081594, 0.07211881130933762, -0.01495696697384119, 0.005830610170960426, -0.013526475057005882, 0.00920848734676838, 0.007558522745966911, -0.004963316954672337, -0.007208057679235935, -0.02606898546218872, -0.019641919061541557, -0.028493473306298256, -0.015015169978141785, -0.00951498281210661, 0.008872682228684425, 0.009662656113505363, 0.0004357672296464443, 0.004006699193269014, -0.01551517378538847, -0.008954138495028019, -0.01774664968252182, 0.01595824398100376, 0.009062331169843674, -0.006508475169539452, 0.020082782953977585, 0.01839073747396469, -0.014124373905360699, -0.0230838805437088, 0.029920918866991997, -0.00326234707608819, -0.03613801300525665, -0.01589982956647873, 0.007811184041202068, -0.0030413209460675716, -0.005149258300662041, 0.0168147012591362, 0.016942795366048813, 0.0018227959517389536, 0.007317368872463703, -0.019155029207468033, -0.024070167914032936, 0.009235282428562641, -0.0050695184618234634, 0.003370135324075818, 0.004246938973665237, 0.01252446137368679, 0.017332468181848526, 0.010399376973509789, 0.007647342048585415, -0.022873405367136, 0.02594645321369171, 0.011322945356369019, -0.007191894575953484, 0.014594979584217072, -0.00449676439166069, 0.008265992626547813, -0.0020967619493603706, -0.03778543323278427, 0.009904342703521252, -0.020669125020503998, 0.0062499758787453175, 0.000637758057564497, -0.009197126142680645, -0.016359321773052216, -0.0064630210399627686, 0.018440594896674156, 0.007900836877524853, 0.018122779205441475, -0.015652896836400032, -0.002685645129531622, 0.015502184629440308, 0.0010460300836712122, 0.011307405307888985, 0.008721934631466866, -0.0057438937947154045, 0.011173443868756294, -0.006700833793729544, 0.013126685284078121, -0.010112561285495758, 0.021799633279442787, -0.001441911794245243, -0.007880554534494877, 0.018248863518238068, 0.02816738188266754, -0.012434090487658978, -0.04932025074958801, 0.0046662683598697186, 0.013088876381516457, -0.00271526793949306, 0.0028914082795381546, 0.00836128555238247, -0.010311897844076157, -0.009248314425349236, 0.0014300462789833546, -0.0321723073720932, 0.008974699303507805, 0.03392159938812256, 0.03331424295902252, 0.0034878584556281567, -0.007770031690597534, 0.008505232632160187, -0.00040441856253892183, -0.01723869889974594, 0.01276172325015068, -0.015272267162799835, -0.0033609915990382433, -0.005607116501778364, 0.002045141300186515, -0.02404254674911499, 0.024108104407787323, 0.010340545326471329, -0.02067028544843197, -0.0003835672978311777, -0.0010605311254039407, -0.006612215656787157, 0.009522187523543835, 0.03444887697696686, -0.013056389056146145, 0.00428724754601717, -0.0006508547812700272, -0.015992028638720512, 0.009693573229014874, 0.010079587809741497, -0.005455911625176668, -0.000671356450766325, 0.026325399056077003, -0.0012482649181038141, -0.00751197524368763, 0.014666039496660233, -0.005173400975763798, -0.020335957407951355, 0.019601499661803246, -0.0453200563788414, -0.0005197927821427584, 0.00665687583386898, -0.008596418425440788, 0.014559141360223293, -0.01420983113348484, 0.0439160019159317, 0.01002325676381588, 0.04456605017185211, -0.009496551938354969, -0.010163997299969196, 0.003509516827762127, 0.012612567283213139, 0.007402108050882816, -0.004304470028728247, -0.005109118297696114, -0.01883704960346222, 0.009953189641237259, -0.005541554652154446, 0.014670878648757935, 0.008547533303499222, -0.008677602745592594, -0.00647017452865839, -0.01014549471437931, 0.014691004529595375, 0.009822100400924683, -0.016171853989362717, -0.01748332753777504, 0.006306788418442011, -0.013026759028434753, -0.016136663034558296, -0.030970469117164612, -0.014294959604740143, 0.041671037673950195, 0.009285214357078075, 0.010392501950263977, -0.0040186806581914425, -0.008297072723507881, -0.0016918131150305271, 0.012313240207731724, -0.012575645931065083, -0.03051050379872322, 0.0014929063618183136, -0.015562931075692177, -0.0118296192958951, -0.019682643935084343, -0.005622090306133032, 0.016473907977342606, -0.0055137453600764275, -0.0022118892520666122, -0.018912915140390396, 0.005648584570735693, -0.009786980226635933, -0.01982538402080536, -0.03444094583392143, -0.02259441837668419, -0.0037525994703173637, 0.0004371372051537037, 0.0010148698929697275, -0.01616692915558815, -0.0037202718667685986, -0.0038062555249780416, -0.0002375865587964654, 0.008168735541403294, -0.03298210725188255, 0.013959125615656376, -0.009659131988883018, 0.002998827025294304, -0.012578124180436134, 0.003406716510653496, -0.012659984640777111 ]
[ 0.24325163662433624, 0.1680595576763153, 0.18319213390350342, 0.3313036561012268, 0.08661849051713943, -0.059777457267045975, 0.10507746040821075, -0.3761650323867798, -0.32109785079956055, -0.11645372211933136, 0.14349310100078583, 0.2432052046060562, -0.6778939962387085, -0.3300980031490326, 0.022139456123113632, -0.0820210799574852, 0.480756938457489, 0.3687330484390259, 0.016550352796912193, -0.671884298324585, -0.21640679240226746, -0.11154266446828842, 0.6792019009590149, -0.2009824514389038, 0.23464661836624146, 0.33788567781448364, 0.13968080282211304, -0.04844498634338379, -0.0008535518427379429, -0.2104305773973465, -0.21963173151016235, 0.7310374975204468, -0.2050877809524536, -0.07375312596559525, -0.3519272208213806, 0.08578804135322571, -0.33840757608413696, -0.14632059633731842, -0.13799986243247986, -0.028416447341442108, -0.35363635420799255, 0.10318401455879211, -0.3340602517127991, 0.340905100107193, -0.2904593348503113, -0.4753638803958893, -1.1746454238891602, 0.5871303677558899, -0.28318583965301514, -0.1861388087272644, -0.11889305710792542, 0.38849037885665894, 0.02282649837434292, 0.2363051474094391, 0.27611738443374634, -0.18822938203811646, -0.644542932510376, -0.2246759682893753, 0.14362379908561707, -0.9338158965110779, -0.17765940725803375, 0.013150878250598907, -0.04367128387093544, 0.15643686056137085, 0.18537606298923492, 0.22036994993686676, -0.09635327011346817, -0.2460486739873886, -0.6277510523796082, 0.27985110878944397, 0.1392166018486023, -0.5728877186775208, -0.6401905417442322, 0.2062511295080185, -0.03739679604768753, -0.24862603843212128, -0.12707816064357758, 0.1636277288198471, 0.1592216044664383, 0.18915624916553497, 0.2882078289985657, -0.05267733708024025, 0.5687322616577148, 0.2555595934391022, 0.711672306060791, 0.4011213183403015, -0.08039920777082443, 0.23448903858661652, -0.32177403569221497, -0.47459864616394043, -0.22911180555820465, -0.42256033420562744, 0.18961921334266663, 0.3506121337413788, 0.37783390283584595, 0.37501010298728943, 0.27602627873420715, -0.14262770116329193, -0.24013158679008484, 0.1594511717557907, -0.08683671057224274, -0.10426519066095352, 0.06573569029569626, -0.2801362872123718, -0.4511788785457611, -0.3477565348148346, 0.2158077210187912, -0.38340044021606445, -0.2303534895181656, -0.1552608609199524, -0.75602126121521, 0.12124941498041153, -0.47984981536865234, -0.01510387659072876, 0.30667954683303833, 0.2061370313167572, 0.12837524712085724, -0.42496126890182495, 0.20844213664531708, 0.15769536793231964, -0.33153048157691956, 1.643341302871704, 0.0588262602686882, 0.5875421166419983, 0.08014913648366928, 0.03221555054187775, 0.21383534371852875, 0.2943613529205322, 0.2423413097858429, 0.49298909306526184, 0.2028602659702301, 0.5983573198318481, 0.11603778600692749, -0.3589569628238678, -0.230437770485878, 0.021602356806397438, 0.2916741371154785, 0.47480231523513794, 0.5721312761306763, 0.46435949206352234, -0.30818745493888855, -0.7501161694526672, -0.0025857954751700163, -0.21575435996055603, -0.11259056627750397, -0.4862799346446991, -0.556365430355072, -0.17462341487407684, 0.30772244930267334, -0.3218868374824524, 0.20197078585624695, -0.20798476040363312, -0.34090301394462585, 0.18343248963356018, -0.14508597552776337, 0.3331978917121887, 0.18820182979106903, -0.24057623744010925, -0.08324478566646576, 0.19867634773254395, 0.2213738113641739, -0.5436098575592041, -0.4009454548358917, -0.017863301560282707, 0.5153434872627258, 0.1346988081932068, 0.6476100087165833, 0.26209303736686707, 0.07007693499326706, -0.23543362319469452, -0.4636602997779846, -0.5575879216194153, 0.07103637605905533, -0.4987172782421112, -0.2151390165090561, -0.4054125249385834, 0.27726131677627563, -0.2248775064945221, -0.035021062940359116, 0.09112280607223511, -0.7191054224967957, -0.12270871549844742, -0.36247608065605164, -0.7641181945800781, 0.2702164351940155, 0.07290848344564438, 0.32837551832199097, -0.13799746334552765, -0.07145910710096359, 0.15250234305858612, 0.03539692610502243, -0.40334194898605347, 0.8783776760101318, -0.6399940252304077, 1.4245555400848389, -0.6086422801017761, -0.15942902863025665, 0.7311608195304871, 0.357683002948761, -0.06934291869401932, -0.5259909629821777, -0.28598493337631226, 0.5302489399909973, -0.1901775449514389, -0.8107143044471741, -0.2637259066104889, -0.26490476727485657, 0.11068319529294968, 0.1352396309375763, -0.269613116979599, 0.12905877828598022, -0.18861836194992065, -0.4171033799648285, -0.0529726967215538, 0.052732061594724655, -0.44953805208206177, -0.3180834949016571, -0.04462932050228119, -0.519393265247345, -0.11598479747772217, 0.13796661794185638, -0.39741864800453186, 0.6313948631286621, 0.5202535390853882, 0.05161484703421593, 0.707972526550293, 0.6771435141563416, 0.2644500136375427, 0.6780697703361511, -0.6308507323265076, 0.5866888165473938, -0.38968610763549805, -0.06967504322528839, -0.4734151065349579, 0.12503035366535187, 0.16236263513565063, -0.16974790394306183, -0.5258378982543945, 0.03593616932630539, -0.4843589663505554, -0.19267430901527405, 0.8412182927131653, -0.7336889505386353, -0.08485908061265945, 0.16738179326057434, -0.5361905694007874, -0.21339817345142365, 0.31437474489212036, -0.9333919286727905, -0.012893730774521828, -0.1472090780735016, 0.4545234143733978, 0.3135649859905243, -0.6234045028686523, -0.0025775849353522062, -0.019792525097727776, -0.07670269906520844, -0.4271683096885681, 0.14013458788394928, -0.5299234986305237, 0.13512097299098969, -0.1174461618065834, 0.2688005268573761, 0.5389705300331116, 0.11651993542909622, -0.16268450021743774, -0.2466437965631485, -0.3760233223438263, 1.205319881439209, 0.6188878417015076, 1.0300743579864502, -0.14701569080352783, -0.40310660004615784, 0.06768902391195297, 0.41161850094795227, -0.7316218018531799, 0.007484891917556524, 0.2810641825199127, -0.2210339903831482, -0.39595937728881836, -0.45513299107551575, 0.4509125351905823, 0.7892585396766663, -0.0772312730550766, -0.38431301712989807, 0.17984917759895325, 0.190049409866333, -0.11619618535041809, 0.15485385060310364, -0.29712721705436707, 0.2535472512245178, 0.11422522366046906, -0.08751735091209412, -0.06631794571876526, 0.6085480451583862, 0.21560007333755493, 0.15003100037574768, 0.7142567038536072, 0.31245389580726624, 0.12420716881752014, -0.026630375534296036, 0.2465437799692154, -0.2523975372314453, -0.32588717341423035, 0.099703349173069, 0.3558618426322937, -0.5837704539299011, 0.42577263712882996, -5.920486927032471, -0.020113347098231316, -0.0561622716486454, -0.7944678664207458, -0.26541808247566223, 0.17502854764461517, 0.7807580828666687, -0.019045373424887657, 0.11150383204221725, 0.48376742005348206, 0.2253011018037796, 0.4018680155277252, -0.04497106373310089, -0.06467709690332413, 0.03163789585232735, -0.09676459431648254, -0.380001425743103, -0.6721931099891663, 0.4874269366264343, -0.15570423007011414, 0.19242113828659058, -0.5257269740104675, 0.03410256281495094, 0.7895981073379517, -0.07901082187891006, -0.07714932411909103, -0.6253331899642944, -0.2286003679037094, -0.06904826313257217, -0.5615159869194031, 0.28797978162765503, -0.6721945405006409, 0.00023545455769635737, -0.41104164719581604, 0.3343975245952606, -0.13977792859077454, 0.39855289459228516, 0.24784202873706818, -0.1692994087934494, -0.17306822538375854, 0.47744160890579224, 0.17442075908184052, -0.3936225175857544, -0.435179740190506, 0.013397806324064732, 0.20602983236312866, -0.17329253256320953, -0.08130451291799545, -1.0339046716690063, 0.6267752647399902, 0.24804586172103882, -0.14171794056892395, -0.2090696096420288, 0.37024134397506714, 0.6283988952636719, 0.09933533519506454, 0.021246351301670074, -0.31777462363243103, -0.6071340441703796, 0.13313892483711243, 0.025635210797190666, -0.22846592962741852, -0.2792498767375946, -0.4609372019767761, 0.19033733010292053, 0.5202203989028931, -0.8087612390518188, -0.6248541474342346, 0.3279735743999481, -0.23445717990398407, -0.11135882139205933, -0.15676195919513702, -0.04648608714342117, -0.7214951515197754, 0.38546261191368103, -0.037226926535367966, 0.34355247020721436, 0.45471587777137756, -0.2085382640361786, -0.28815019130706787, -0.15624664723873138, -0.01889510452747345, 0.0686504915356636, -0.39154312014579773, 0.3682542145252228, 0.22403551638126373, -0.8690482974052429, -0.3365912139415741, -0.06468690186738968, 0.5312795042991638, 0.6501405239105225, -0.07008115202188492, -0.13184353709220886, 0.8214549422264099, 0.09588644653558731, 0.653153657913208, 0.28987258672714233, 0.2865942120552063, 0.32825997471809387, 0.08635526895523071, 0.6413386464118958, 0.441459983587265, -0.8124220371246338, -0.540919303894043, -0.31624504923820496, 0.4618363678455353, -0.19380834698677063, 0.21737922728061676, 0.2178592085838318, -0.7656918168067932, -0.0819196105003357, -0.08361262083053589, -0.37004077434539795, -0.19205941259860992, 0.7078081965446472, -0.2815302908420563, -0.5837377905845642, 0.049008436501026154, 0.8451314568519592, -0.40905460715293884, -0.06074506416916847, 0.33737075328826904, -0.2070131152868271, 0.36482498049736023, -0.6764557361602783, -0.4629400372505188, -0.08802594989538193, 0.8400331139564514, -0.8843304514884949, 0.02514420635998249, 0.2831035852432251, -0.027848796918988228, -0.11247244477272034, 0.19427290558815002, 0.14067701995372772, -0.10879703611135483, -0.24972060322761536, 0.2107159048318863, 0.5114555358886719, -0.10175666213035583, 0.14440923929214478, 0.011549615301191807, -0.03449973464012146, 0.23886427283287048, 0.48879626393318176, 0.009231670759618282, -0.2799060344696045, 0.21675364673137665, -0.5593088865280151, -0.058858081698417664, 0.28199875354766846, -0.21863095462322235, 0.03940211236476898, -0.18811313807964325, -0.13881491124629974, 0.5017485618591309, 0.43658268451690674, -0.038961369544267654, 0.8307941555976868, -0.30273085832595825, 0.49072375893592834, -0.018090473487973213, -0.8956251740455627, 0.01101569551974535, -0.4301774501800537, -0.30997568368911743, -0.19557097554206848, -0.1276496946811676, -0.2725381553173065, -0.18289239704608917, -0.00021376588847488165, -0.17591936886310577, 0.05985470861196518, -0.051575008779764175, -0.25081920623779297, -0.4066052734851837, -0.3470933437347412, 0.17396199703216553, -0.2758558392524719, 0.10953624546527863, 0.07581103593111038, -0.41462045907974243, 0.03518356755375862, 0.11605791002511978, 0.17798607051372528, -0.0038859876804053783, 0.14670072495937347, -0.10226847976446152, -0.2150110900402069, -0.35228726267814636, 0.3361625373363495, 0.2369479537010193, 0.4029900133609772, 0.06252752989530563, 0.3348473012447357, -0.14186015725135803, 0.1147167757153511, 0.2498326301574707, -0.08373153209686279, -0.6054611802101135, 0.15175504982471466, 0.1725935935974121, 0.055508747696876526, 0.2633720338344574, 0.7607981562614441, 0.02528199926018715, -0.26551544666290283, 0.14361025393009186, -0.2042706459760666, 0.11223133653402328, 0.016110774129629135, -0.6700737476348877, -0.1536923348903656, 0.09606349468231201, 0.06014786660671234, -0.19142664968967438, 0.632770836353302, -0.24570073187351227, -0.3915823698043823, 0.34789058566093445, 0.7336313128471375, 0.09710489213466644, -0.27021729946136475, -0.38522493839263916, -0.4336917996406555, 0.2228502780199051, 0.44368451833724976, -0.8049991726875305, 0.5236340761184692, -0.04465548321604729, -0.4154806435108185, 0.048563167452812195, 0.17154157161712646, 0.4127519130706787, -0.3704766631126404, -0.5896520018577576, -0.6545522809028625, 0.22665828466415405, 0.14345905184745789, 0.6695162653923035, 0.04371320456266403, 0.4298601448535919, -0.45535776019096375, -0.10948199033737183, -0.12752683460712433, 0.4156690239906311, 0.16168612241744995, -0.1905798763036728, -0.5619673728942871, -0.28455883264541626, 0.6421136856079102, 0.021447641775012016, 0.29287832975387573, 0.6850109696388245, 0.8252952098846436, 0.2503041625022888, 0.06742596626281738, -0.3108564019203186, -0.03559676557779312, 0.3463338315486908, -0.4554995000362396, -0.17024236917495728, -0.6053065657615662, -0.010280104354023933, 0.47725287079811096, 0.12349996715784073, -0.01590854860842228, -0.8810595870018005, 0.3821796178817749, -0.38486796617507935, 0.05326412618160248, 0.15454192459583282, 0.7879798412322998, -0.00022016763978172094, 0.036548443138599396, 0.028320960700511932, -0.2648293375968933, 0.48051467537879944, 0.03578081727027893, 0.32428881525993347, 0.03502970188856125, -0.22227895259857178, 0.5046935081481934, -0.2954709231853485, 0.4788614809513092, -0.7215933203697205, 0.4018343389034271, -0.6900199055671692, 0.3558230400085449, -0.28757670521736145, -0.47767630219459534, 0.16808152198791504, -0.7617148160934448, -0.2630626857280731, 0.1523205190896988, 0.2328467220067978, 0.4224689304828644, -0.07519998401403427, -0.08413303643465042, 0.03629958629608154, -0.45863810181617737, -0.018450014293193817, 0.41049474477767944, 0.06597255915403366, -0.4481043517589569, 0.04768524318933487, 0.29134273529052734, -0.15332429111003876, -0.6516135931015015, -0.0035975624341517687, -0.033012062311172485, 0.017380354925990105, 0.4312796890735626, 0.038747016340494156, -0.32747748494148254, 0.5024815797805786, 0.01158274058252573, -0.06208690628409386, 0.2957151532173157, 0.23708760738372803, 0.1965019553899765, 0.4443340003490448, 0.6475556492805481, -0.30145490169525146, -0.1809062659740448, -0.05022108927369118, 0.24783872067928314, 0.5984060168266296, 0.09949034452438354, 0.43282660841941833, 0.7450947761535645, 0.4700726270675659, 0.2102176547050476, 0.7989009618759155, 0.4647226631641388, 0.13104143738746643, 0.10540486872196198, -0.27777573466300964, -0.6666038632392883, -0.055417586117982864, 1.0124889612197876, 0.586233913898468, -0.10618369281291962, -0.22273211181163788, 0.24194467067718506, 0.13968242704868317, 0.052791863679885864, 0.4628700613975525, -0.4637981355190277, 0.5804653167724609, 0.2610138952732086, 0.08481082320213318, -0.8709399104118347, -0.0872546061873436, -0.1431061178445816, -0.14176300168037415, 0.40411773324012756, 0.014869829639792442, -0.34675782918930054, 0.44077858328819275, -0.4584016799926758, 0.5177237391471863, 0.14133062958717346, 0.4686680734157562, -0.2557721734046936, 0.27475759387016296, 0.34475627541542053, 0.23554560542106628, 0.46542975306510925, 0.1207403838634491, 0.010348685085773468, 0.08520276099443436, -0.11942241340875626, 0.19931739568710327, -0.45793968439102173, -0.42782101035118103, -0.013568426482379436, -0.5042840838432312, 0.4203854203224182, 0.25518178939819336, -0.026522479951381683, 0.3403899371623993, -0.3025679588317871, -0.5514606237411499, 0.2536081075668335, -0.4403112232685089, -0.5736708045005798, -0.3390461206436157, -0.025568552315235138, -0.14399059116840363, -0.2225404977798462, -0.7495721578598022, 0.5621982216835022, 0.2924835681915283, -0.06160148233175278, 0.009732026606798172, -0.04130932688713074, 0.2239840030670166, 0.3250272274017334, 0.28544339537620544, 0.18592821061611176, 0.2063971310853958, -0.1467544436454773, 0.17429137229919434, -0.13575848937034607, 0.4901299476623535, -0.352973997592926, -0.6137371063232422, -0.19862914085388184, -0.03840054199099541, 1.0043870210647583, 0.6321035623550415, -0.4084584712982178, 0.09839150309562683, 0.5275572538375854, 0.5579533576965332, 0.15088890492916107, -0.3522508442401886, -0.3389301896095276, -0.6121022701263428, -0.2914171814918518, -0.595956563949585, 0.5712082386016846, -0.2720295190811157, -0.14162680506706238, 0.10034546256065369, 0.3820658028125763, -0.15770122408866882, -0.2850179970264435, -0.11077912896871567, -0.2475653737783432, -0.32908472418785095, -0.6381278038024902, 0.016300644725561142, -0.4984011948108673, 0.2186465859413147, -0.20517104864120483, 0.26073381304740906, 0.1941322535276413, -0.4104757010936737, -0.0021860385313630104, 0.4468286633491516, 0.4850026071071625, 0.31707513332366943, 0.29017168283462524, 0.2819097340106964, -0.1805843561887741, -0.5289231538772583, -0.7560823559761047, 0.27879247069358826, -0.10631835460662842, -0.16697730123996735, -0.2518387734889984, 0.12638086080551147, -0.0562361478805542, -0.14990147948265076, 0.07321780174970627, -0.037006180733442307, -0.3894449472427368, -0.13576467335224152 ]
Immune checkpoint inhibitors have been identified as breakthrough treatment in melanoma given its dramatic response to PD-1/PD-L1 blockade. This is likely to extend to many other cancers as hundreds of clinical trials are being conducted or proposed using this exciting modality of therapy in a variety of malignancies. While immune checkpoint inhibitors have been extensively studied in melanoma and more recently in lung cancer, little is known regarding immune checkpoint blockade in other cancers. This review will focus on the tumor immune microenvironment, the expression of PD-1/PD-L1 and the effect of immune modulation using PD-1 or PD-L1 inhibitors in patients with head and neck, prostate, urothelial, renal, breast, gastrointestinal and lung cancers.
[ 0.02013910748064518, -0.00027782144024968147, -0.013817152939736843, 0.0013717242982238531, 0.011970460414886475, 0.025268390774726868, 0.008561423979699612, 0.007502314634621143, -0.01581140235066414, 0.025142833590507507, -0.007274285890161991, 0.012081227265298367, -0.004896447993814945, 0.008324318565428257, -0.0012099576415494084, 0.028325874358415604, -0.021416151896119118, 0.012138888239860535, 0.010504577308893204, 0.027953384444117546, -0.017135992646217346, 0.009447834454476833, 0.008813363499939442, 0.017912309616804123, -0.0033223070204257965, 0.00912188459187746, -0.03451968729496002, -0.009134512394666672, -0.016564402729272842, 0.01764059066772461, -0.027568576857447624, 0.007077493704855442, 0.034879930317401886, -0.03377353027462959, -0.006767783779650927, -0.023315895348787308, -0.004619093611836433, 0.018940329551696777, 0.006623821798712015, -0.004536343738436699, -0.00943823903799057, -0.007505116518586874, 0.0078959409147501, -0.01401505433022976, -0.005630592815577984, -0.018717173486948013, -0.00455513596534729, -0.01862492971122265, -0.0021636467427015305, 0.007307581137865782, 0.004619077779352665, 0.010565097443759441, -0.013356335461139679, -0.03854617476463318, -0.005904775578528643, -0.009457798674702644, 0.016591545194387436, -0.036102958023548126, -0.0024044355377554893, -0.019818589091300964, 0.029623273760080338, -0.0717196837067604, -0.0001314873807132244, -0.021379290148615837, -0.01695016212761402, -0.06712791323661804, -0.021075718104839325, -0.035263966768980026, 0.004418124444782734, -0.032541774213314056, 0.0068426597863435745, 0.013258324936032295, 0.009135482832789421, 0.00538672087714076, -0.01995277777314186, -0.0228751078248024, -0.013878963887691498, 0.02400108054280281, 0.03567051887512207, 0.010143130086362362, -0.02909168228507042, -0.008655092678964138, 0.01865873858332634, 0.03050251305103302, -0.012073257006704807, 0.0039050420746207237, -0.003355039283633232, -0.004365067463368177, 0.00478730071336031, 0.02000589109957218, 0.0019838185980916023, -0.017719518393278122, -0.015285843051970005, -0.022822115570306778, 0.004492221400141716, -0.034013278782367706, -0.03732168674468994, -0.01710347831249237, -0.01461939699947834, 0.00665481761097908, -0.005143908318132162, -0.00390169071033597, 0.007034839130938053, -0.024339234456419945, 0.019584499299526215, 0.007380292750895023, -0.0005776758189313114, -0.03063894994556904, 0.018240859732031822, 0.007989531382918358, -0.01369377039372921, -0.009339994750916958, -0.005935037974268198, 0.004023445304483175, 0.007036775350570679, 0.0024138514418154955, 0.010748463682830334, -0.00026185810565948486, 0.006452706176787615, 0.023953961208462715, 0.02748158946633339, 0.012768389657139778, -0.0007670338964089751, 0.01856175996363163, 0.0036221493501216173, -0.01616683416068554, -0.008588584139943123, 0.009089520201086998, -0.00042891455814242363, -0.0004196322988718748, -0.006492741405963898, 0.00967961922287941, -0.011059945449233055, -0.04223337024450302, 0.0010927733965218067, 0.0026960335671901703, -0.01372324489057064, 0.0006839921697974205, 0.01334382500499487, -0.010307036340236664, -0.019564714282751083, 0.012573129497468472, 0.001750820316374302, 0.01647023856639862, 0.016415689140558243, 0.014099128544330597, 0.011327007785439491, 0.002435836708173156, -0.02563881129026413, 0.03411400690674782, 0.010747113265097141, 0.022037716582417488, -0.012405365705490112, -0.016008321195840836, 0.027832673862576485, 0.018407128751277924, -0.009610764682292938, -0.016420066356658936, -0.00642878282815218, -0.042611487209796906, 0.01454109326004982, -0.0037731919437646866, -0.005419125314801931, 0.008469710126519203, -0.001128362724557519, 0.004664799198508263, -0.02862456999719143, -0.015774399042129517, 0.000020437524653971195, 0.004912128206342459, -0.019677355885505676, 0.0018489919602870941, -0.010780403390526772, 0.007450825069099665, 0.015188135206699371, -0.0022919485345482826, 0.005290118511766195, 0.007771958597004414, 0.0020393754821270704, 0.06707972288131714, -0.004792025778442621, 0.015731409192085266, 0.040846407413482666, -0.011790554039180279, 0.012047572992742062, -0.017799507826566696, 0.010701920837163925, -0.005900145974010229, 0.000391998328268528, -0.02226966992020607, -0.018610306084156036, 0.019225560128688812, -0.03419081121683121, 0.007476043421775103, -0.003045002231374383, 0.002471286803483963, 0.01007896289229393, 0.008081384003162384, 0.019588652998209, 0.012425519526004791, 0.04895537346601486, 0.009790689684450626, -0.013296430930495262, -0.021969379857182503, 0.01660851761698723, 0.019371692091226578, -0.0177603866904974, -0.02994314581155777, -0.0003908569924533367, -0.006062634754925966, 0.0011041867546737194, -0.004772972781211138, -0.021643588319420815, 0.0025819307193160057, 0.010971404612064362, 0.01257924735546112, -0.007414599880576134, -0.011011744849383831, -0.011024381965398788, -0.017802875488996506, -0.001536381198093295, 0.04088868945837021, 0.022046294063329697, 0.020966924726963043, 0.018466461449861526, -0.014424028806388378, -0.004444595891982317, 0.01118273101747036, 0.006862034555524588, 0.007625475060194731, -0.015004461631178856, -0.02189946174621582, -0.016157114878296852, -0.0014180154539644718, -0.0015469985082745552, -0.017879657447338104, 0.011934767477214336, -0.03297479450702667, 0.02226005494594574, -0.01666215807199478, 0.011362533085048199, -0.025158077478408813, 0.031545091420412064, 0.02023162692785263, 0.006184761878103018, -0.0058526694774627686, 0.001263332087546587, 0.018235547468066216, 0.002650209004059434, -0.007155187427997589, 0.009221162647008896, -0.02264331839978695, -0.0174967460334301, -0.018401242792606354, -0.01645219512283802, -0.0037116617895662785, -0.009636743925511837, -0.020278241485357285, 0.021095411852002144, -0.017570532858371735, 0.004984005820006132, 0.008594982326030731, -0.03515256196260452, -0.02560509741306305, 0.011923539452254772, 0.0034141121432185173, -0.010609917342662811, 0.020268268883228302, 0.03043886460363865, 0.010039025917649269, 0.007282203529030085, -0.00524858059361577, -0.01518419198691845, -0.08140933513641357, -0.0049988990649580956, 0.001804454019293189, -0.016632476821541786, 0.012656580656766891, -0.0365254282951355, 0.02484491467475891, 0.0056611355394124985, -0.008693643845617771, 0.004038583021610975, -0.015403415076434612, 0.006219306495040655, -0.002641061320900917, 0.019153166562318802, 0.00103035569190979, -0.015878530219197273, 0.009001115337014198, -0.020128019154071808, -0.01871625706553459, -0.06150679662823677, 0.0004159649834036827, -0.01584106683731079, 0.0017055482603609562, -0.004856240004301071, 0.0010194052010774612, 0.00023831124417483807, 0.01761787012219429, 0.00774370925500989, -0.00315824244171381, -0.001452843425795436, -0.00622723950073123, -0.005805997643619776, -0.008561603724956512, -0.00013993214815855026, 0.012278256937861443, -0.014408145099878311, -0.014784231781959534, 0.01634659245610237, -0.003216874785721302, 0.023317070677876472, 0.014399207197129726, 0.014989053830504417, 0.008645892143249512, 0.013379229232668877, 0.0049543920904397964, 0.01571713015437126, -0.0027048978954553604, 0.04833941534161568, 0.01132550835609436, -0.026534004136919975, -0.016436006873846054, 0.007466574665158987, -0.031631626188755035, 0.025274256244301796, -0.0021530641242861748, -0.03725245222449303, -0.02662799321115017, -0.003149639815092087, -0.009488838724792004, -0.008902398869395256, 0.020112700760364532, 0.0062250010669231415, 0.053456030786037445, 0.032354243099689484, -0.004086165688931942, 0.01504830364137888, 0.006070110946893692, -0.013093842193484306, -0.006668465211987495, 0.003353561507537961, 0.006296183913946152, -0.03087499924004078, -0.021883942186832428, -0.004684126004576683, 0.02760426327586174, 0.00036373749026097357, -0.011263611726462841, -0.02820957638323307, 0.016286080703139305, 0.003064836608245969, -0.0019276479724794626, -0.0018472245428711176, -0.013519272208213806, 0.0004525361582636833, -0.018759645521640778, 0.03355646878480911, 0.012246734462678432, -0.0006372435018420219, 0.014075660146772861, -0.02244608663022518, 0.017323266714811325, 0.01647249609231949, -0.008418286219239235, 0.005924715660512447, 0.008463605307042599, -0.025376658886671066, -0.009875659830868244, 0.005993681028485298, 0.024108247831463814, 0.008594144135713577, -0.011271749623119831, -0.0004582407418638468, 0.004496788140386343, -0.011487577110528946, -0.03772895783185959, 0.010949337854981422, 0.029362158849835396, -0.0016711577773094177, -0.0241558738052845, -0.002110627945512533, -0.0013407100923359394, 0.009141828864812851, -0.011453764513134956, 0.03940485045313835, 0.010363019071519375, 0.003776256227865815, -0.0006096285069361329, -0.021157965064048767, 0.07222424447536469, -0.00672194454818964, 0.009331786073744297, -0.00048256409354507923, 0.023934416472911835, -0.027389045804739, -0.011657178401947021, -0.0009358441457152367, -0.00022323615849018097, 0.01560074184089899, 0.009970605373382568, -0.03203700855374336, 0.01192014291882515, -0.0011427903082221746, -0.009837877005338669, 0.017486046999692917, -0.007237711921334267, 0.01807490363717079, 0.010120810940861702, -0.02417028322815895, 0.0052014305256307125, -0.0031640203669667244, -0.0011516748927533627, -0.0013745692558586597, 0.01097812969237566, -0.0010654921643435955, 0.013961274176836014, -0.014265742152929306, -0.018384071066975594, 0.0018294635228812695, -0.00869283638894558, 0.009902294725179672, -0.005622493103146553, 0.014529860578477383, 0.005858775228261948, 0.015957102179527283, -0.0012354915961623192, -0.017319874837994576, 0.0030115684494376183, 0.003913844004273415, -0.023863842710852623, -0.015380680561065674, 0.00010088086128234863, 0.004929433576762676, -0.02616973966360092, 0.022464530542492867, -0.006212329491972923, -0.008798330090939999, -0.009515179321169853, -0.01017318107187748, -0.01604158617556095, 0.008615953847765923, 0.009772403165698051, 0.01096856128424406, -0.021962178871035576, -0.014937641099095345, 0.0022015837021172047, 0.00679878331720829, -0.020499762147665024, 0.007095434702932835, -0.0015886430628597736, -0.022849220782518387, 0.016462070867419243, -0.007466388400644064, -0.0023348235990852118, -0.0006714621558785439, 0.0009235949255526066, -0.0211472325026989, -0.005046274978667498, -0.014986637979745865, -0.04416718706488609, -0.005323973949998617, -0.006108989007771015, -0.0033558171708136797, -0.02937847375869751, 0.008696197532117367, -0.010354858823120594, 0.004970295820385218, 0.014165999367833138, -0.00035091000609099865, -0.031111836433410645, -0.019050855189561844, 0.01946272701025009, -0.026036135852336884, 0.0070013925433158875, -0.005746339447796345, -0.0009122239425778389, -0.0737127885222435, -0.01633477210998535, -0.01755381003022194, -0.00508506502956152, -0.02728193625807762, 0.013998689129948616, -0.026584966108202934, 0.023734115064144135, -0.014691032469272614, -0.004827222321182489, -0.005666370503604412, 0.02215246483683586, 0.008974871598184109, -0.013553466647863388, 0.015318901278078556, -0.002882047789171338, 0.03768531605601311, -0.0025443623308092356, -0.016276929527521133, -0.046910516917705536, -0.02160843275487423, 0.0069608138874173164, -0.020633582025766373, 0.011325223371386528, -0.0020955640356987715, -0.08104468882083893, -0.006756842136383057, -0.015529800206422806, -0.055393464863300323, -0.022397108376026154, -0.016460973769426346, 0.026747215539216995, -0.009642031975090504, -0.04626889526844025, -0.01563795655965805, 0.0036964742466807365, -0.002029882976785302, 0.026296071708202362, 0.0014747318346053362, -0.011524439789354801, -0.0071153598837554455, 0.019098028540611267, -0.005492771975696087, 0.01757582649588585, -0.0026180774439126253, 0.005373675841838121, -0.007599410600960255, -0.007401952054351568, -0.01406150683760643, -0.0036444752477109432, -0.014360638335347176, -0.016993485391139984, 0.015719154849648476, 0.008890359662473202, -0.02919669821858406, -0.009702913463115692, -0.05271480605006218, -0.01850815862417221, -0.029927965253591537, -0.0053871311247348785, -0.004279230255633593, 0.010096903890371323, 0.03052612952888012, -0.016300583258271217, -0.0233474001288414, -0.0011245871428400278, 0.041347991675138474, 0.000012963544577360153, 0.009484468027949333, 0.007195332553237677, 0.03705182671546936, 0.009919251315295696, -0.0015555424615740776, 0.00694013386964798, 0.0003533530980348587, 0.005616853479295969, 0.016228267922997475, -0.008737335912883282, -0.0025378086138516665, 0.0015796753577888012, -0.019087906926870346, -0.00698684761300683, 0.017379742115736008, 0.0025682002305984497, 0.018744952976703644, -0.004788611084222794, -0.000011686934158205986, -0.011787502095103264, 0.07225354015827179, -0.01192007027566433, 0.03423955291509628, -0.04822196811437607, -0.004691850394010544, 0.0019676797091960907, 0.021259963512420654, 0.003389159217476845, -0.02296692505478859, -0.00822356902062893, 0.012256935238838196, -0.0163604486733675, 0.023599976673722267, 0.009607478976249695, -0.04760307818651199, 0.014411002397537231, 0.024107379838824272, 0.0033498515840619802, 0.007894951850175858, 0.005636756308376789, 0.020892605185508728, 0.017361506819725037, -0.019448084756731987, -0.03348908945918083, -0.00668265949934721, -0.001934615196660161, -0.018878232687711716, -0.017385439947247505, -0.015064877457916737, 0.01696159318089485, 0.012623380869626999, 0.027223097160458565, -0.0002520099515095353, 0.029398445039987564, 0.005136425606906414, 0.02022995799779892, -0.01558367908000946, 0.007578507997095585, -0.004790101200342178, 0.010623825713992119, 0.040452100336551666, 0.009216376580297947, 0.008411884307861328, -0.004888650495558977, 0.026111606508493423, 0.030003860592842102, -0.0015346561558544636, -0.012494763359427452, 0.02152738720178604, -0.013261168263852596, -0.019728772342205048, 0.002185549819841981, 0.017754124477505684, 0.02068621665239334, -0.0005808272399008274, -0.0035740204621106386, -0.014257139526307583, 0.01071851421147585, -0.007679888047277927, -0.01509302668273449, 0.03308280557394028, -0.02315031737089157, -0.0039418963715434074, -0.001559228403493762, 0.022562045603990555, 0.0072473944164812565, 0.015291809104382992, -0.017184924334287643, -0.0030553299002349377, 0.01136702299118042, -0.008073797449469566, -0.019696345552802086, 0.007718525826931, -0.009310107678174973, 0.007235224358737469, 0.005346291698515415, 0.021848946809768677, -0.00727985892444849, -0.0058828736655414104, 0.0016494167502969503, -0.0056529869325459, 0.009122053161263466, -0.00876698363572359, -0.006248602643609047, -0.010858391411602497, 0.03108002431690693, 0.021202806383371353, 0.006748308893293142, -0.006211535073816776, 0.010578254237771034, 0.011378356255590916, 0.004692788235843182, 0.000247612246312201, -0.011603794991970062, 0.0036268294788897038, 0.03297686576843262, -0.0017855686601251364, 0.0017361580394208431, -0.004120043013244867, 0.02933047153055668, -0.0026056149508804083, 0.014058651402592659, -0.04643091559410095, -0.0015122927725315094, -0.007514305412769318, -0.006792766507714987, 0.0163922980427742, 0.008526802062988281, -0.009746918454766273, 0.031199710443615913, -0.021329043433070183, 0.0012343849521130323, 0.005088191479444504, 0.024838857352733612, 0.009186815470457077, 0.03223171457648277, -0.005364845506846905, 0.022971823811531067, 0.0051592574454844, -0.012172795832157135, -0.0010574676562100649, 0.002518940716981888, -0.024049442261457443, -0.024152424186468124, -0.010410239920020103, 0.002957205520942807, -0.013874238356947899, -0.013730326667428017, -0.01672939956188202, 0.007412147708237171, 0.021037716418504715, 0.02320718951523304, -0.010545802302658558, -0.01739158108830452, -0.005301536526530981, -0.03687787428498268, -0.011932111345231533, 0.02991528809070587, 0.014087904244661331, 0.012825846672058105, -0.021727919578552246, -0.022814687341451645, -0.0006121216574683785, -0.039232365787029266, 0.00928125623613596, -0.01199653372168541, 0.003964237403124571, -0.024941254407167435, -0.0007329008658416569, 0.025539454072713852, 0.0021623503416776657, 0.004953685216605663, 0.006084644701331854, -0.00013539631618186831, 0.000012084143236279488, 0.0198785699903965, 0.009647111408412457, 0.004456889815628529, 0.00548614701256156, -0.012634392827749252, -0.01275394856929779, 0.026919052004814148, -0.0007601939141750336, 0.00796353630721569, 0.007221586536616087, 0.006382170133292675, -0.010242011398077011, -0.02218424156308174, 0.017765581607818604, -0.015682624652981758, 0.04953072592616081, -0.031126901507377625, -0.02162635698914528, 0.02867601439356804, -0.019504617899656296, 0.001408894662745297, 0.0003634961321949959, 0.008678171783685684, 0.004887433256953955, 0.020398078486323357, 0.025149572640657425, -0.011264299973845482, -0.004438860807567835, -0.004489087034016848, -0.02404855191707611, -0.009805724024772644, -0.019357213750481606, -0.022065594792366028, 0.00038994348142296076, 0.025128649547696114, 0.003835740964859724, 0.009294288232922554, 0.0012944755144417286, 0.00232639629393816, 0.0077458033338189125, 0.003260692348703742, -0.02377636730670929, -0.02050764299929142, 0.01104426383972168, -0.002915982622653246, 0.0029473621398210526, -0.021770834922790527 ]
[ -0.016347534954547882, -0.06803188472986221, 0.12045513838529587, -0.1529051512479782, 0.13409264385700226, -0.5112192034721375, 0.2764902412891388, -0.3613995909690857, 0.04523365944623947, -0.5836940407752991, 0.16663309931755066, 0.4091593027114868, -0.5193105936050415, 0.056665752083063126, 0.06593069434165955, 0.6770775318145752, 0.5386903285980225, 0.3838733732700348, -0.20491087436676025, -0.5064168572425842, -0.12862060964107513, 0.08162513375282288, 0.447887659072876, -0.2591005563735962, 0.010030265897512436, 0.09627556055784225, 0.6168153285980225, 0.01725654862821102, 0.20259824395179749, -0.2417004406452179, 0.11940594762563705, 0.6247921586036682, -0.5974175930023193, -0.3756260573863983, -0.29799509048461914, 0.1892290860414505, -0.3393937051296234, 0.1364746391773224, -0.17045949399471283, -0.3064756691455841, -0.41162583231925964, -0.2149575650691986, -0.3799420893192291, 0.8639364838600159, -0.12183622270822525, -0.21564196050167084, -1.2063597440719604, 0.2441009134054184, -0.31106963753700256, -0.3602970242500305, 0.18606282770633698, -0.02085483819246292, 0.14093904197216034, 0.09804919362068176, 0.7888392806053162, -0.030513731762766838, -0.8741373419761658, -0.37714889645576477, 0.4686605930328369, 0.15568038821220398, -0.05649939179420471, -0.026185866445302963, -0.5273381471633911, -0.0009904173202812672, 0.02695881389081478, 0.4645001292228699, 0.21633288264274597, -0.20818467438220978, -0.35373181104660034, -0.31233158707618713, 0.042294472455978394, -0.6081555485725403, 0.028015080839395523, 0.08138386160135269, 0.22802868485450745, -0.23238247632980347, 0.10476905852556229, -0.37081465125083923, 0.01871040090918541, -0.04663636535406113, 0.2889116704463959, -0.0016067554242908955, 0.11653445661067963, -0.3482342064380646, 0.4424525201320648, 0.1368064433336258, -0.03042273223400116, 0.6493753790855408, -0.5932947397232056, -0.03211750462651253, 0.08454465121030807, -0.1389782428741455, 0.4874189794063568, 0.15108610689640045, 0.3071511685848236, 0.437588095664978, -0.37249237298965454, 0.3121582567691803, 0.18122752010822296, 0.13346578180789948, 0.11876102536916733, 0.17717917263507843, -0.19539886713027954, -0.4464273154735565, -0.579307496547699, -0.5137364268302917, -0.2601999342441559, -0.3841296434402466, -1.0290583372116089, 0.18679232895374298, -0.7214186787605286, 0.4662829041481018, -0.152023583650589, -0.053971558809280396, -0.38342583179473877, 0.4127335548400879, 0.1467009335756302, -0.09309880435466766, -0.22141242027282715, 0.2427806258201599, 0.20494979619979858, 1.9491826295852661, -0.3432433009147644, 0.8822359442710876, -0.030137494206428528, -0.06437192112207413, 0.4398272931575775, 0.32823747396469116, -0.05981782078742981, 0.4595675766468048, -0.019843053072690964, 0.6719449162483215, -0.5701115727424622, -0.13841262459754944, 0.22289255261421204, -0.049895115196704865, -0.049341995269060135, 0.08375165611505508, 0.3371939957141876, 0.15438680350780487, -0.5115252733230591, -0.5347529649734497, 0.17179326713085175, 0.06279348582029343, -0.24776186048984528, -0.06183217465877533, 0.01191040314733982, 0.3611644208431244, 0.04976370930671692, -0.057996202260255814, -0.026483625173568726, -0.2734333574771881, -0.7421879768371582, 0.2610747218132019, -0.16867294907569885, 0.5858988761901855, -0.14340679347515106, -0.30743277072906494, -0.06266992539167404, 0.08941252529621124, 0.02621310204267502, -0.3308745324611664, -0.3710986077785492, -0.06644433736801147, 0.7405417561531067, -0.2788068354129791, 0.034212324768304825, 0.1808539777994156, 0.6289657950401306, -0.04202975332736969, -0.574033796787262, -0.23292426764965057, -0.4566599726676941, -0.9564472436904907, 0.3080819845199585, -0.414693683385849, 0.598467230796814, 0.04403414577245712, 0.060667868703603745, 0.2690463960170746, -0.8210622668266296, -0.21734069287776947, -0.006644331384450197, -0.5876834392547607, 0.3568587005138397, 0.6406778693199158, 0.7181581258773804, 0.12940005958080292, 0.1966686099767685, 0.24011875689029694, -0.06931048631668091, 0.3105011582374573, 0.6197530627250671, -0.5674000978469849, 1.5403721332550049, 0.10722672939300537, 0.13981184363365173, 1.4959919452667236, -0.1493908315896988, -0.043365832418203354, -0.01774599589407444, 0.08224426209926605, 0.5458683967590332, -0.11739064753055573, -0.844925045967102, -0.19862331449985504, 0.05845169350504875, -0.3711293935775757, -0.22505824267864227, 0.21868588030338287, 0.873620867729187, -0.33025655150413513, 0.1805519312620163, -0.06671032309532166, 0.039361678063869476, -0.17979837954044342, -0.009201046079397202, 0.21125948429107666, -0.5697680711746216, 0.07963506877422333, 0.293953537940979, -0.7887678742408752, 0.5805290937423706, 1.4906625747680664, 0.29340994358062744, 0.6632084250450134, 0.44732293486595154, -0.17349404096603394, 0.6266037821769714, 0.02558598667383194, 0.10621228814125061, -0.5716772675514221, 0.28659120202064514, -0.34831905364990234, 0.00423438148573041, 0.041508521884679794, -0.025851711630821228, -0.3783634305000305, -0.026353251188993454, 0.17388036847114563, -0.18366456031799316, 0.37506142258644104, -0.5153753161430359, 0.34581923484802246, 0.2938121557235718, -0.2560615539550781, 0.079030841588974, 0.2628995180130005, -0.7672664523124695, -0.30298107862472534, 0.02612532675266266, 0.3259603679180145, 0.3429252803325653, -0.9909976720809937, 0.3043960630893707, 0.33634909987449646, -0.6859241127967834, -0.35658177733421326, -0.030735069885849953, -0.4478664696216583, -0.23891210556030273, 0.2769767940044403, 0.116705983877182, 0.04530254751443863, -0.06347478181123734, -0.31489992141723633, -0.5373703837394714, -0.24394209682941437, 0.7064499258995056, 0.35745155811309814, 0.8547218441963196, 0.29781538248062134, -0.611478865146637, -0.19091323018074036, -0.4537973701953888, -0.6659421920776367, -0.317984402179718, 0.9535205960273743, -0.83848637342453, -0.03249756991863251, 0.10533785820007324, 0.837894082069397, 0.8570506572723389, -0.4929259419441223, -0.8155677318572998, -0.16992156207561493, 0.02545909397304058, -0.7682202458381653, -0.9657402634620667, -0.0780806913971901, 0.027835169807076454, 0.02282147854566574, -0.7601929306983948, 0.3786507844924927, 0.215934157371521, 0.05662655830383301, 0.06522802263498306, 0.4193907082080841, 0.6175235509872437, -0.030171865597367287, 0.18322500586509705, 0.16279853880405426, -0.3675149977207184, 0.18646226823329926, -0.33258113265037537, -0.21598735451698303, -0.34749510884284973, 0.28852519392967224, -5.482760429382324, -0.1549053192138672, -0.2241712361574173, 0.44420015811920166, -0.41577988862991333, -0.16106772422790527, 0.9344558119773865, -0.13159841299057007, 0.6242485046386719, 0.3380381464958191, 0.36680173873901367, 0.736603856086731, 0.08235719054937363, 0.0014440380036830902, -0.348407119512558, 0.07833566516637802, 0.05785771459341049, -0.094769686460495, 0.8547005653381348, -0.0017476488137617707, 0.6555839776992798, -0.05941574648022652, -0.31774643063545227, 0.8273046612739563, -0.2629995048046112, 0.008165698498487473, -0.8819621205329895, 0.49385523796081543, -0.12498023360967636, -0.23043788969516754, 0.308256596326828, -0.25020352005958557, 0.05264384299516678, -0.5126780271530151, 0.17811602354049683, 0.31040313839912415, 0.16169339418411255, 0.2419867366552353, -0.18243831396102905, -0.4623933434486389, 0.3328086733818054, 0.15366004407405853, -0.2498387098312378, 0.1022740975022316, 0.13332092761993408, 0.018464041873812675, 0.3036574423313141, 0.42041802406311035, -0.2219657450914383, 1.0144023895263672, -0.014838224276900291, -0.4225539565086365, 0.4700778126716614, 0.8381941318511963, 0.4997292160987854, -0.4270488917827606, -0.4694207012653351, 0.09313257038593292, -0.28700387477874756, 0.6010086536407471, -0.6996790170669556, 0.00946742668747902, -0.49025288224220276, -0.6593522429466248, 0.21001774072647095, 0.4141417145729065, -0.5050018429756165, -0.9854142665863037, 0.2833748757839203, -0.4516158699989319, -0.416547566652298, 0.3884805142879486, 0.5066231489181519, -0.557784914970398, 0.625217854976654, -0.13989770412445068, 0.28479936718940735, 0.10274550318717957, -0.4062294661998749, 0.10108315944671631, -0.6124229431152344, -0.10410792380571365, -0.2543138563632965, -0.004275529645383358, 0.7902175784111023, -0.4446726441383362, -0.08431195467710495, 0.02185293659567833, -0.22980813682079315, 0.07740508019924164, 0.651185929775238, -0.22608603537082672, 0.24703249335289001, 0.2887091040611267, 0.3009265661239624, 0.8657873868942261, 0.08992285281419754, 0.5889022350311279, 0.3690072298049927, -0.059407398104667664, 0.9656667709350586, 0.17867140471935272, -0.15304182469844818, -0.9687922596931458, -0.08136145025491714, -0.006563705857843161, -0.43890437483787537, -0.2559029161930084, 0.5290305018424988, -1.133704662322998, 0.0081713842228055, -0.3370039761066437, -0.6735658049583435, 0.07484909892082214, 0.6280816197395325, -0.3582279682159424, -0.3353513479232788, 0.12321595847606659, 0.3640094995498657, -0.2346823364496231, 0.2210942506790161, 0.3162287771701813, -0.34041064977645874, 0.26424935460090637, -0.057472504675388336, -0.27354174852371216, -0.15930236876010895, 0.7542980909347534, -0.35201969742774963, 0.0923171117901802, 0.4156282842159271, 0.6412919163703918, -0.9603431224822998, -0.04482712224125862, 0.0885748565196991, -0.5582033395767212, -0.7785668969154358, 0.2415524423122406, -0.17835019528865814, -0.08851509541273117, -0.12089618295431137, -0.6155291199684143, -0.029137972742319107, 0.09731301665306091, 0.2899281084537506, -0.24752485752105713, -0.09110261499881744, -0.12830311059951782, -0.560215413570404, 0.09841340035200119, 0.004286687821149826, 0.30992719531059265, -0.06438709050416946, -0.13923236727714539, 0.1636800318956375, 0.7985919117927551, 1.1662731170654297, 0.10987834632396698, 0.5482041835784912, -0.6394056677818298, 0.29681524634361267, 0.3089839518070221, -0.6721011996269226, 0.21273212134838104, 0.1843283772468567, -0.4128974378108978, -0.3517623245716095, -0.353841632604599, 0.14559395611286163, 0.1673867553472519, -0.39369726181030273, -0.3736669719219208, -0.5884540677070618, -0.3978217542171478, 0.19677068293094635, 0.34435051679611206, -0.6645854115486145, 0.2532705068588257, -0.19159597158432007, -0.3714914619922638, 0.22090193629264832, -1.0161274671554565, -0.30614736676216125, 0.4019443690776825, 0.7153096795082092, -0.4739421308040619, -0.008906771428883076, -0.43566298484802246, -0.264833927154541, -0.60747891664505, 0.5191854238510132, 0.10087231546640396, 0.11577662080526352, -0.29837319254875183, 0.01440874207764864, -0.4229343831539154, -0.09567905962467194, 0.2781057059764862, -0.14242298901081085, -0.9261440634727478, 0.11368418484926224, 0.7084311246871948, -0.026708317920565605, 0.4517113268375397, 0.3591429591178894, -0.22715239226818085, -0.32397833466529846, 0.40741533041000366, -0.10068461298942566, 0.06606897711753845, -0.3477146029472351, -0.9092655181884766, 0.4906987249851227, 0.5003038048744202, -0.35573017597198486, 0.26530176401138306, -0.2896534204483032, -0.14355158805847168, -0.3655281066894531, 0.41630542278289795, 0.2778777480125427, -0.6506254076957703, -0.05857605114579201, 0.009062017314136028, -0.7342218160629272, -0.0031811045482754707, 0.3864055275917053, -0.7429654598236084, -0.047833964228630066, 0.008193358778953552, 0.004422273952513933, -0.23434145748615265, -0.005020335782319307, -0.05773695185780525, -0.05551282688975334, -0.2074970006942749, -0.2871527671813965, 0.43145641684532166, -0.11069682985544205, 0.5700743794441223, -0.06478045880794525, 0.21430043876171112, -0.3945601284503937, -0.30525442957878113, -0.10785707086324692, 0.4633670449256897, 0.6128546595573425, -0.333353191614151, -0.7953097820281982, 0.14218921959400177, -0.09903274476528168, -0.11854980140924454, 0.05188320577144623, 0.2358456701040268, 1.3997879028320312, -0.02382105588912964, 0.12673315405845642, -0.3405296802520752, -0.28956514596939087, 0.21395081281661987, -0.5516301393508911, 0.1445409655570984, -0.4798600375652313, -0.3241952359676361, 0.14251106977462769, -0.2462184727191925, -0.017895517870783806, -1.1485050916671753, 0.36713892221450806, -0.2864331305027008, -0.4577711224555969, -0.6960363984107971, 0.9600025415420532, 0.4391135573387146, -0.11348628252744675, 0.30673882365226746, -0.09891101717948914, -0.06396269798278809, -0.41140130162239075, 0.5794588923454285, -0.09659169614315033, -0.32339176535606384, 0.2738546133041382, -0.650259256362915, 0.5143269300460815, -0.8699111938476562, 0.11892420053482056, -0.30772849917411804, 0.28386178612709045, -0.3004886209964752, -0.10748708993196487, 0.01714458130300045, -0.7838574051856995, -0.16780927777290344, -0.23060815036296844, 0.4558297097682953, -0.1444249153137207, -0.13496814668178558, -0.2830165922641754, -0.5303450226783752, -0.20912860333919525, 0.6805723309516907, 0.38956496119499207, -0.08533069491386414, -0.010134371928870678, 0.646942675113678, 0.4436519145965576, 0.19351385533809662, -0.2774456739425659, 0.05042729899287224, -0.21471765637397766, 0.01898198574781418, 0.6686842441558838, 0.7398477792739868, -0.4599387049674988, 0.5276626944541931, -0.06075451895594597, -0.011119858361780643, 0.2853015661239624, -0.04285450652241707, 0.4875998795032501, 0.5660235285758972, 0.5308944582939148, -0.08785726875066757, -0.6560267210006714, 0.6459068655967712, 0.03488069400191307, -0.17377813160419464, -0.11333978921175003, 0.9071647524833679, 0.6375752091407776, 0.6283309459686279, -0.01326037012040615, 0.4050336182117462, 0.4347783923149109, 0.14389318227767944, 0.3776129484176636, -0.32573238015174866, -0.5219632387161255, 0.025881975889205933, 0.4031248986721039, -0.045430298894643784, -0.5677754282951355, 0.17161062359809875, 0.3963060677051544, 0.5531985759735107, 0.4929993748664856, 0.04653218016028404, -0.14972418546676636, 0.11695291101932526, -0.0035806933883577585, -0.08434724062681198, -0.6527724862098694, 0.32425838708877563, -0.6861395239830017, -0.053638290613889694, 0.625923216342926, -0.568700909614563, -0.00703825568780303, -0.00778864836320281, 0.3636952042579651, -0.3265787661075592, -0.20522797107696533, 0.7117886543273926, -0.295129656791687, 0.04351392760872841, 0.42124107480049133, 0.2842008173465729, 0.4248363971710205, -0.2516530454158783, 0.006189980544149876, -0.36395129561424255, 0.09355267882347107, 0.493545264005661, 0.23416486382484436, -0.5210985541343689, -0.11054395139217377, -0.009057426825165749, 0.10003978759050369, 0.4573577344417572, 0.007496893405914307, 0.43234288692474365, -0.4856816530227661, -0.7268685102462769, -0.23290972411632538, -0.23356452584266663, -0.6557088494300842, 0.16217707097530365, 0.01425416674464941, 0.025797128677368164, 0.21095234155654907, -0.16833935678005219, -0.22596226632595062, 0.26832446455955505, 0.19796642661094666, -0.21588923037052155, 0.18584519624710083, 0.5921743512153625, -0.4267597794532776, 0.5480276942253113, 0.12089454382658005, 0.4626483917236328, -0.21407677233219147, 0.8535257577896118, -0.7972217798233032, 0.5532240271568298, -0.8763459324836731, -0.006721026264131069, -0.4953441917896271, -0.1740894466638565, 0.9285256266593933, 0.8576539158821106, -0.13906003534793854, -0.12728455662727356, 0.21524016559123993, 0.07947304099798203, 0.09673452377319336, -0.4908851981163025, -0.3046448528766632, -0.5222691893577576, -0.06329777836799622, -0.4982112646102905, 0.4731805920600891, -0.37695980072021484, -0.5828543305397034, -0.08454648405313492, 0.630408525466919, 0.2916237413883209, 0.0012006141478195786, 0.25920411944389343, 0.06956201046705246, -0.17628897726535797, -0.5824598670005798, 0.4784572422504425, -0.5557900071144104, -0.196180522441864, -0.15725454688072205, -0.07057013362646103, 0.2465377300977707, 0.16249144077301025, 0.3536597192287445, -0.0576166957616806, 0.30822089314460754, 0.1591208428144455, 0.05752390995621681, -0.37452778220176697, -0.37127047777175903, -0.9499369263648987, -0.7043600082397461, 0.346836656332016, -0.04820635914802551, -0.2385758012533188, -0.10866750031709671, 0.5766763091087341, 0.2008722573518753, 0.2854551374912262, -0.3290841281414032, -0.6268482208251953, -0.39999598264694214, -0.35529690980911255 ]
The allocation of hypoglycaemic symptoms to autonomie or neuroglycopenic groups tends to occur on an a priori basis. In view of the practical need for clear symptom markers of hypoglycaemia more scientific approaches must be pursued. Substantial evidence is presented from two large scale studies we performed which support a three factor model of hypoglycaemic symptomatology, based on the statistical associations discovered among symptoms reported by diabetic patients. Study 1 involved 295 insulin-treated outpatients and found that 11 key hypoglycaemic symptoms segregated into three clear factors: autonomie (sweating, palpitation, shaking and hunger) neuroglycopenic (confusion, drowsiness, odd behaviour, speech difficulty and incoordination), and malaise (nausea and headache). The three factors were validated on a separate group of 303 insulin-treated diabetic out-patients. Confirmatory factor analyses showed that the three factor model was the optimal model for explaining symptom covariance in each group. A multi-sample confirmatory factor analysis tested the rigorous assumptions that the relative loadings of symptoms on factors across groups were equal, and that the residual variance for each symptom was identical across groups. These assumptions were successful, indicating that the three factor model was replicated in detail across these two large samples. It is suggested that the results indicate valid groupings of symptoms that may be used in future research and in clinical practice.
[ 0.0022133877500891685, 0.01754166930913925, -0.010299715213477612, 0.023069176822900772, 0.008430995047092438, -0.004504610784351826, 0.010459891520440578, 0.024027328938245773, -0.01986088976264, -0.0076491073705255985, 0.0005614818073809147, 0.012648493982851505, -0.01948876492679119, 0.005563055165112019, -0.003423247952014208, -0.012899122200906277, -0.007934344932436943, -0.03288588672876358, 0.013462341390550137, 0.020821506157517433, 0.012121474370360374, 0.0064888461492955685, 0.011081233620643616, 0.026133447885513306, -0.011547062546014786, 0.004551192745566368, 0.01876841112971306, -0.03781070560216904, -0.018280409276485443, -0.014207139611244202, -0.006280255503952503, -0.00020558619871735573, 0.0012671835720539093, -0.009679131209850311, 0.0009201598586514592, 0.00670573441311717, 0.008417392149567604, 0.021259073168039322, -0.04261220246553421, -0.0007244095322676003, 0.014664551243185997, -0.008977114222943783, -0.010800718329846859, -0.004489880986511707, -0.008518625982105732, 0.024989884346723557, -0.005979948677122593, -0.0015411737840622663, -0.00772187951952219, 0.0055886306799948215, -0.0014852272579446435, 0.0052856761030852795, -0.010339549742639065, -0.006281876005232334, -0.006478757597506046, -0.0049786921590566635, 0.023964401334524155, 0.01224919967353344, -0.048188213258981705, 0.005787011701613665, -0.0011128524783998728, 0.005644550547003746, 0.012433050200343132, 0.026746800169348717, -0.037924423813819885, -0.06663097441196442, 0.004579002968966961, 0.03284307196736336, 0.00864581298083067, -0.006070047616958618, 0.015972789376974106, 0.01774631440639496, 0.015141205862164497, 0.011349355801939964, 0.015779510140419006, 0.010677022859454155, 0.0018406759481877089, 0.00682893767952919, -0.010466251522302628, -0.0007836255244910717, -0.003961002454161644, -0.004344068467617035, -0.006316673010587692, 0.03626175969839096, 0.005075674504041672, -0.006254585459828377, -0.023205598816275597, 0.014633440412580967, 0.00572416465729475, 0.012980306521058083, 0.01297488622367382, 0.009903392754495144, -0.006878984626382589, 0.01616385020315647, -0.0021011466160416603, -0.021021900698542595, -0.015634197741746902, 0.009982479736208916, 0.013356927782297134, -0.025903139263391495, 0.004288175143301487, 0.0015773484483361244, 0.02390374429523945, 0.0033221589401364326, -0.028764095157384872, 0.006209204439073801, -0.004513303283601999, 0.015169680118560791, -0.0190257765352726, 0.00417023990303278, 0.006798506248742342, 0.01719462312757969, 0.011255348101258278, 0.012172892689704895, 0.023735813796520233, 0.0003787796013057232, -0.00327433948405087, -0.01270756870508194, 0.0034311239141970873, 0.0010549803264439106, 0.01823381893336773, -0.021399203687906265, -0.004460996948182583, 0.000792559003457427, -0.0015449924394488335, -0.018504688516259193, 0.020402126014232635, 0.005295940209180117, 0.012237286195158958, 0.005798020865768194, -0.0059369709342718124, -0.0011145472526550293, 0.026623990386724472, 0.026608997955918312, 0.007551671005785465, -0.00026610714849084616, -0.014508784748613834, 0.010031315498054028, -0.004267530515789986, -0.016274381428956985, -0.029545437544584274, 0.012125220149755478, 0.00006469048094004393, 0.006340167950838804, -0.00948265939950943, 0.004324709996581078, -0.015826616436243057, -0.008324144408106804, 0.004448290448635817, -0.04807213693857193, 0.004042394924908876, -0.0062921056523919106, -0.0022698803804814816, -0.0032232014928013086, -0.01449074037373066, 0.00796190183609724, -0.012070214375853539, 0.019909963011741638, -0.004526006057858467, 0.0055932048708200455, -0.01687387377023697, 0.008337512612342834, 0.012857848778367043, 0.009834256023168564, 0.010030773468315601, 0.01670873537659645, 0.03370989114046097, 0.0028179422952234745, -0.0018536748830229044, -0.0015466584591194987, -0.007601909339427948, 0.002589365467429161, 0.022654123604297638, 0.007493212819099426, 0.007445244118571281, -0.00643449742347002, -0.01310360711067915, 0.005385577213019133, 0.013530113734304905, 0.06664803624153137, -0.030454162508249283, -0.001529407687485218, -0.023787155747413635, 0.023917675018310547, -0.00858654547482729, -0.0031059044413268566, 0.005504218861460686, -0.013995243236422539, 0.009707383811473846, -0.007187587209045887, -0.010425809770822525, -0.0009367526508867741, 0.044183745980262756, -0.00014049955643713474, -0.01976187154650688, 0.0031587532721459866, 0.007788962684571743, -0.00048674113349989057, -0.006434632930904627, 0.0075561003759503365, 0.02222132310271263, -0.006814225111156702, -0.004444663412868977, -0.012782846577465534, -0.012332482263445854, 0.008443225175142288, -0.007348887622356415, -0.011281082406640053, -0.013873610645532608, 0.006797099020332098, 0.01624998450279236, -0.00045205000787973404, 0.01572766900062561, -0.0056615471839904785, -0.027902444824576378, 0.005524212494492531, -0.019442416727542877, 0.005584326572716236, -0.04008947312831879, -0.021647989749908447, 0.0100164245814085, 0.006108197849243879, -0.032206881791353226, -0.0019659779500216246, 0.010848801583051682, -0.03614006191492081, -0.0016701421700417995, 0.005160466767847538, -0.0031644157133996487, -0.0022309483028948307, -0.018328042700886726, -0.015300791710615158, -0.006627017166465521, -0.0022058463655412197, 0.006057907827198505, 0.001307375729084015, 0.015387694351375103, -0.003228855784982443, 0.006864028051495552, -0.015469534322619438, -0.0019421135075390339, -0.0390249565243721, 0.025647267699241638, -0.018220651894807816, 0.006654997356235981, 0.005934980232268572, 0.02910788543522358, 0.030109873041510582, -0.0171671025454998, 0.0030949856154620647, 0.004049618728458881, 0.01991882547736168, -0.015094617381691933, -0.0029522054828703403, -0.007322209421545267, -0.029770631343126297, 0.03779854252934456, 0.0011745833326131105, 0.027948904782533646, -0.004648025147616863, 0.00910218060016632, 0.0028926865197718143, 0.022864658385515213, 0.00021654460579156876, -0.007207292597740889, 0.002091307658702135, 0.012366325594484806, 0.004428597167134285, 0.023346401751041412, -0.016667606309056282, 0.003501709783449769, -0.006594101898372173, -0.00653674453496933, -0.08151053637266159, -0.014027871191501617, -0.014527034014463425, 0.018670273944735527, 0.008025561459362507, -0.0010958556085824966, 0.01728227734565735, 0.02228846773505211, -0.00232478859834373, -0.0068693519569933414, 0.0108355563133955, 0.0061567965894937515, -0.004323490429669619, 0.030301686376333237, -0.0029142717830836773, -0.002398451091721654, 0.0035784279461950064, -0.0015726482961326838, -0.009117823094129562, -0.01349625363945961, 0.00006866967305541039, 0.01542278379201889, 0.005819625221192837, -0.009741421788930893, 0.036138877272605896, 0.03518142178654671, 0.010888345539569855, -0.004303789231926203, -0.044756919145584106, 0.006063500884920359, -0.0009182463400065899, -0.01382121630012989, 0.002762703225016594, -0.008356820791959763, 0.015617760829627514, 0.003960655070841312, -0.005414203274995089, 0.01065346971154213, -0.015235627070069313, -0.016932182013988495, -0.0027984161861240864, 0.009395217522978783, -0.004637276753783226, 0.0031150898430496454, 0.009819915518164635, -0.015662871301174164, 0.04483697935938835, -0.0014179963618516922, 0.008249331265687943, 0.004477373789995909, 0.024506380781531334, -0.004803960677236319, 0.003514912910759449, 0.008743401616811752, -0.011906381696462631, 0.0016662224661558867, -0.029206831008195877, 0.004004152026027441, -0.012304184958338737, -0.0019538060296326876, -0.003222804283723235, -0.002348719397559762, -0.03271351009607315, 0.0018214867450296879, -0.029632527381181717, -0.04692588001489639, 0.01037905178964138, 0.023867907002568245, 0.004282435867935419, -0.01361454464495182, 0.009697061032056808, -0.03987869620323181, -0.013310883194208145, -0.0018871207721531391, 0.004057286772876978, -0.004826089832931757, -0.01460200548171997, -0.010390589013695717, 0.005462635308504105, -0.012734849005937576, 0.00673987390473485, 0.004962225444614887, -0.007469938136637211, -0.013410634361207485, -0.005659717135131359, 0.034049391746520996, 0.008587699383497238, 0.029487598687410355, 0.022677019238471985, -0.010586893185973167, 0.017938926815986633, 0.02134026028215885, -0.036901723593473434, 0.008181018754839897, 0.008846044540405273, 0.00830333773046732, 0.004421565681695938, 0.0013533104211091995, 0.0007106233388185501, 0.009890217334032059, -0.003711559809744358, -0.004285363480448723, -0.011587291024625301, -0.008043527603149414, 0.013253896497189999, 0.011412393301725388, -0.008383098989725113, -0.010702617466449738, -0.007051199674606323, -0.012863347306847572, 0.012500709854066372, -0.018261991441249847, -0.002239774912595749, -0.011352828703820705, -0.003081093542277813, 0.007552262861281633, 0.017524266615509987, 0.01160367764532566, 0.07174275070428848, 0.0020355163142085075, 0.028185252100229263, -0.019879404455423355, 0.009276514872908592, -0.02382948249578476, 0.012463990598917007, 0.013362443074584007, -0.0038882263470441103, -0.018228018656373024, 0.014832772314548492, -0.006867219693958759, 0.020037135109305382, 0.019375447183847427, -0.033532097935676575, 0.014642933383584023, 0.007047258783131838, -0.010456273332238197, -0.0032863859087228775, 0.0073438361287117004, 0.021653415635228157, 0.01636314205825329, 0.004061941988766193, -0.004583719186484814, 0.011734478175640106, -0.044811565428972244, -0.014955658465623856, -0.01537172682583332, -0.0037474501878023148, -0.001699618762359023, 0.0029781374614685774, 0.014757989905774593, -0.004252520389854908, 0.028206197544932365, 0.014585549011826515, 0.01995496079325676, 0.017181307077407837, -0.00829956866800785, 0.0025483500212430954, 0.011758591048419476, -0.014817586168646812, -0.008199299685657024, -0.002909642644226551, 0.014029310084879398, 0.004698486998677254, -0.002859703730791807, 0.0008584754541516304, -0.0038888761773705482, -0.013093107379972935, 0.0389493964612484, -0.0020842605736106634, -0.0012470863293856382, 0.006295130122452974, 0.019523710012435913, 0.00019125407561659813, -0.004545003175735474, -0.015325579792261124, -0.008960917592048645, -0.013313669711351395, -0.010790077969431877, 0.007180030457675457, -0.009649560786783695, 0.018152909353375435, 0.01668008789420128, 0.007202494889497757, 0.002325385343283415, 0.007759573869407177, -0.008845597505569458, -0.004656188189983368, 0.011402063071727753, -0.0031461326871067286, 0.001042017713189125, -0.0007162368856370449, -0.010068373754620552, -0.017088063061237335, -0.0037231610622256994, 0.015505475923418999, -0.03229981288313866, 0.0005882137920707464, -0.0025122202932834625, -0.004106109030544758, 0.01211312785744667, -0.0030071658547967672, -0.027078796178102493, 0.013185432180762291, 0.016809843480587006, -0.0038875965401530266, -0.07477634400129318, -0.013518458232283592, -0.012675084173679352, -0.006632473785430193, -0.003686602460220456, 0.02300829440355301, -0.023053383454680443, -0.005351698957383633, -0.040601447224617004, -0.002492514904588461, 0.016313329339027405, 0.0016864908393472433, -0.002591842319816351, 0.003123810514807701, 0.012520168907940388, 0.04028300195932388, -0.01758827269077301, -0.01025993749499321, -0.00580256525427103, 0.019881170243024826, 0.0027370136231184006, 0.006335131824016571, -0.039570510387420654, 0.00009273085743188858, 0.007726466283202171, -0.08081751316785812, 0.0016663530841469765, 0.004237375222146511, -0.01164616271853447, -0.011748652905225754, 0.014594795182347298, 0.006910474039614201, -0.01216173730790615, 0.00008819904178380966, -0.019034648314118385, 0.022860335186123848, -0.022572655230760574, 0.002990850480273366, 0.0010264484444633126, 0.011893201619386673, -0.008742393925786018, 0.01708526350557804, 0.014999373815953732, -0.011903541162610054, 0.016264503821730614, -0.017394481226801872, 0.02153380773961544, -0.005757679231464863, 0.009033873677253723, -0.004829485900700092, -0.00021317554637789726, -0.013257374987006187, 0.01358666829764843, -0.0007873396389186382, -0.007963316515088081, 0.0008135457755997777, 0.00938517227768898, -0.0017545809969305992, -0.005982441361993551, -0.009486834518611431, -0.020669661462306976, -0.021541127935051918, -0.0018676288891583681, -0.012127237394452095, -0.01687784120440483, 0.0015464350581169128, -0.015124626457691193, -0.015508780255913734, 0.005228171590715647, 0.014253218658268452, -0.004677481018006802, 0.0018687861738726497, -0.007783118635416031, 0.013117766007781029, 0.0027773911133408546, 0.012467296794056892, 0.007241952233016491, -0.004020461812615395, -0.009073632769286633, -0.002115572802722454, 0.008799048140645027, -0.0024807152803987265, 0.038246143609285355, -0.0007879128679633141, 0.012295329011976719, 0.0038759689778089523, 0.01633702963590622, -0.014620274305343628, 0.0713496059179306, -0.025409121066331863, 0.0033546036574989557, -0.011284693144261837, -0.013922581449151039, -0.007832719013094902, -0.018863892182707787, -0.003925114404410124, -0.005981913302093744, -0.011017555370926857, -0.026782434433698654, -0.014927584677934647, 0.021984048187732697, 0.002197402296587825, 0.003237738274037838, 0.013246024958789349, -0.02505105920135975, -0.03608739748597145, -0.018783017992973328, -0.009091785177588463, -0.0003803584259003401, 0.014272230677306652, -0.03897010162472725, -0.0034930428955703974, 0.009503185749053955, 0.0014626103220507503, -0.01186017319560051, 0.01674647256731987, -0.016682259738445282, 0.002686559921130538, -0.029893387109041214, -0.004794178064912558, 0.004866224713623524, 0.0022133667953312397, 0.01045813225209713, 0.009974826127290726, -0.009970523416996002, 0.0013384997146204114, -0.014938265085220337, -0.003785794833675027, 0.008118988946080208, 0.0061849988996982574, 0.004372242838144302, -0.020353207364678383, 0.0023591062054038048, -0.0068070730194449425, 0.006812719628214836, 0.013828281313180923, -0.01863384246826172, 0.014434857293963432, 0.002838253043591976, -0.0013621406396850944, 0.018111784011125565, 0.005361699033528566, 0.0065760305151343346, -0.008627868257462978, -0.02663429267704487, 0.02945675328373909, -0.015009353868663311, -0.01581769809126854, 0.02087898552417755, -0.02429211139678955, 0.011271890252828598, -0.018562640994787216, -0.0012108262162655592, -0.014438197016716003, 0.00041872262954711914, -0.017524201422929764, -0.002858595922589302, 0.014791717752814293, -0.008621716871857643, 0.03839926794171333, -0.00024064021999947727, 0.005541736260056496, 0.0026499845553189516, 0.008426972664892673, -0.007675841450691223, -0.014054845087230206, 0.031231418251991272, 0.0032585898879915476, -0.011738158762454987, -0.013910780660808086, 0.012134774588048458, -0.017517540603876114, 0.016004635021090508, -0.013733706437051296, -0.004556338302791119, 0.010763732716441154, -0.0064127701334655285, 0.001841197139583528, -0.021990984678268433, -0.0003860576543956995, -0.012236014939844608, -0.009642508812248707, 0.007301517762243748, 0.03627274930477142, -0.001564531121402979, 0.014953386038541794, -0.008585486561059952, -0.015115030109882355, 0.004306623712182045, 0.01063060574233532, 0.02344219759106636, 0.00014565279707312584, -0.00612683966755867, 0.0012422767467796803, 0.011887190863490105, 0.00217409897595644, 0.03726784139871597, 0.0027543120086193085, 0.007089552469551563, -0.051580678671598434, 0.03599841892719269, -0.009194927290081978, 0.01113281212747097, -0.0042655146680772305, -0.003488848451524973, 0.03622538596391678, 0.021930400282144547, -0.014840351417660713, -0.022927891463041306, -0.003052007406949997, -0.0019544544629752636, 0.029773196205496788, 0.019327182322740555, -0.023160453885793686, -0.007313244044780731, 0.017706550657749176, 0.007322785910218954, 0.006087893154472113, 0.018324092030525208, -0.008968368172645569, 0.0022529177367687225, 0.028061095625162125, 0.012849308550357819, -0.0023839010391384363, -0.01827852427959442, 0.025515984743833542, -0.02213236503303051, -0.008376769721508026, 0.022335533052682877, 0.00020868773572146893, 0.00006989113171584904, -0.010488701984286308, 0.010023636743426323, -0.009983712807297707, -0.016330841928720474, 0.03579297661781311, 0.010347303003072739, -0.0013284576125442982, -0.009142112918198109, 0.008587476797401905, -0.013522656634449959, -0.0006187671096995473, -0.013481682166457176, -0.002400590106844902, 0.013410592451691628, 0.028400469571352005, -0.02614797279238701, -0.01230957917869091, 0.0011233256664127111, -0.011664796620607376, -0.012841489166021347, 0.00708342157304287, -0.02279926836490631, 0.056020524352788925, -0.01283962931483984, 0.001382238115184009, -0.005042685195803642, -0.018376927822828293, 0.004502472933381796, -0.003986227326095104, -0.012688754126429558, 0.028290677815675735, -0.014610428363084793, 0.0007309734355658293, -0.018152568489313126, -0.010964865796267986, 0.012545953504741192, 0.003993901889771223, 0.01084880344569683, -0.00030169636011123657, 0.0007040731143206358, -0.010756568983197212, 0.0019184293923899531, 0.00805431418120861, -0.0025041380431503057, -0.014801716431975365, 0.011531672440469265, 0.015212899073958397, -0.016027741134166718, -0.019455650821328163, -0.037649158388376236, 0.004311148077249527, -0.008844925090670586, -0.029750145971775055, -0.005253702402114868, 0.024968553334474564, 0.016147829592227936, 0.002933485433459282, 0.016326185315847397, -0.01608295738697052 ]
[ 0.23741351068019867, 0.14186495542526245, -0.1759767234325409, 0.05349712446331978, -0.4545159935951233, 0.5302632451057434, 0.49857190251350403, -0.5290473103523254, -0.24158763885498047, -0.2176058143377304, -0.021530725061893463, 0.23854376375675201, -0.5914807319641113, 0.15914824604988098, -0.16368511319160461, 0.8382425308227539, 0.3799246847629547, 0.26624295115470886, -0.3507957458496094, -0.43400558829307556, -0.17349477112293243, -0.2758321762084961, 0.42495599389076233, -0.3046317398548126, -0.15660645067691803, 0.20252951979637146, 0.41110339760780334, 0.12293818593025208, 0.200565367937088, 0.05622434988617897, 0.007959231734275818, 1.0399295091629028, 0.03444840386509895, -0.3162359595298767, 0.10012944042682648, 0.1497696340084076, 0.13398002088069916, -0.4155784547328949, 0.4198688268661499, -0.381841778755188, -0.059503618627786636, 0.1392909437417984, -0.35610246658325195, 0.4711526930332184, -0.06956669688224792, -0.3574431538581848, -1.5441608428955078, 0.26051783561706543, -0.08839986473321915, 0.022558458149433136, 0.040749531239271164, 0.23456226289272308, 0.4409621059894562, 0.3186992108821869, -0.14872342348098755, 0.31610268354415894, -0.7201558947563171, -0.2547914385795593, 0.17538729310035706, -0.04105030372738838, 0.06467670202255249, 0.10021232068538666, 0.3221633732318878, 0.23134392499923706, -0.35207948088645935, 0.23941203951835632, -0.1460917592048645, 0.1603592187166214, -0.6524271368980408, 0.008879097178578377, -0.07933206856250763, -0.44487035274505615, 0.1279788464307785, 0.30045658349990845, -0.33133557438850403, 0.36461105942726135, 0.08738931268453598, -0.5699062347412109, 0.41022956371307373, -0.13394658267498016, -0.06376577913761139, 0.07870860397815704, 0.3198883533477783, -0.10430531948804855, 0.5207031965255737, 0.41123712062835693, 0.051931723952293396, 0.5148484706878662, -0.10710811614990234, 0.23713839054107666, -0.2768670916557312, -0.2115011066198349, 0.21932046115398407, 0.07770263403654099, 0.02000505104660988, 0.6257076263427734, 0.6549571752548218, -0.031052198261022568, 0.1541917622089386, 0.18941433727741241, 0.31340935826301575, 0.17867280542850494, -0.09061743319034576, -0.23319779336452484, -0.5971765518188477, -0.43345320224761963, 0.008563417010009289, -0.5965025424957275, -0.4278344213962555, 0.05430486425757408, -1.1364479064941406, 0.13292275369167328, -0.25616654753685, -0.28036823868751526, -0.07938336580991745, -0.0030760846566408873, -0.10115836560726166, -0.3846188485622406, -0.11868955940008163, 0.018382500857114792, -0.396218478679657, 0.6187944412231445, -0.15380187332630157, 0.3000280559062958, -0.02828422375023365, -0.12007440626621246, 0.45821166038513184, 0.254763662815094, -0.03810625150799751, 0.28340253233909607, 0.12918922305107117, 0.4200150966644287, -0.13627523183822632, -0.2982054352760315, -0.00196733046323061, -0.14471642673015594, -0.11168346554040909, 0.37105685472488403, 0.15236514806747437, 0.044981516897678375, -0.16519607603549957, -0.7233666181564331, -0.39737340807914734, 0.0938699021935463, 0.22878430783748627, -0.18024177849292755, 0.15862734615802765, 0.23765508830547333, -0.20735876262187958, -0.22531236708164215, -0.2989508807659149, 0.2888977825641632, -0.22946810722351074, 0.09836454689502716, 0.2053416669368744, 0.5583176612854004, -0.33425843715667725, -0.7960603833198547, 0.40026384592056274, -0.020736118778586388, 0.2624245882034302, -0.18104155361652374, -0.3843216598033905, 0.16258221864700317, 0.5122718811035156, -0.14953234791755676, -0.09939174354076385, 0.3824510872364044, -0.04524758458137512, -0.11630994826555252, -0.3066495358943939, -0.27579841017723083, -0.4255351126194, -0.4681469202041626, -0.28481489419937134, 0.22257019579410553, 0.4385322630405426, 0.384443998336792, 0.24735796451568604, -0.2717147469520569, -0.6582151651382446, -0.019787266850471497, 0.15670745074748993, -0.6363751888275146, 0.41206908226013184, 0.15704257786273956, 0.40798917412757874, -0.01714988797903061, -0.10163883119821548, -0.20937728881835938, 0.02112439088523388, -0.35052400827407837, 0.665441632270813, -0.5189400315284729, 1.7361164093017578, -0.1269322782754898, -0.2128394991159439, 0.6600964069366455, 0.30461856722831726, -0.36293792724609375, 0.24048441648483276, -0.07467824965715408, 0.14511878788471222, -0.04693976789712906, -0.8067947030067444, -0.08451589941978455, -0.285754531621933, -0.23733924329280853, -0.29513615369796753, 0.17783507704734802, 0.6035686135292053, -0.6235198378562927, -0.23028555512428284, -0.33230847120285034, -0.03357294201850891, 0.0003087409131694585, 0.11130406707525253, 0.6451975703239441, -0.028275728225708008, -0.14498920738697052, 0.5806560516357422, -0.500404417514801, 0.49854978919029236, 0.5001591444015503, 0.30145329236984253, 0.5112789273262024, 0.796209454536438, 0.38823312520980835, 1.109430193901062, -0.7561752200126648, 0.2670721709728241, -0.0098214540630579, 0.6520728468894958, -0.5076040625572205, -0.08388232439756393, 0.27243682742118835, -0.03537125885486603, -0.47770166397094727, 0.0013119602808728814, -0.21927277743816376, -0.23511072993278503, 0.23185133934020996, -0.8197183012962341, 0.15212328732013702, 0.35854390263557434, -0.4772733449935913, -0.6198990345001221, 0.5425945520401001, -0.9625242948532104, 0.12154195457696915, -0.03574478253722191, 0.5432649254798889, 0.26515913009643555, -0.4151037037372589, 0.322250634431839, 0.39038586616516113, 0.14525040984153748, -0.685644268989563, -0.17213954031467438, -0.4991300404071808, -0.24257072806358337, 0.40869176387786865, 0.12388042360544205, 0.4042399227619171, 0.1090177372097969, -0.7605875134468079, -0.810383677482605, -0.4813520014286041, 0.5180912613868713, 0.5216460227966309, 1.1905462741851807, -0.3182758390903473, -0.7184460759162903, 0.08022838830947876, -0.21277490258216858, -0.5543524622917175, -0.14432989060878754, 0.7056545615196228, -0.6719349026679993, -0.36009055376052856, -0.09031219780445099, 0.34325361251831055, 0.9782865643501282, 0.03071109764277935, -0.2506432831287384, -0.16428330540657043, -0.059016820043325424, -0.3788910508155823, -0.21963855624198914, -0.4454898536205292, 0.13795050978660583, 0.7292665243148804, -0.15949369966983795, -0.5863177180290222, 0.32092010974884033, 0.24841269850730896, -0.37583044171333313, 0.5873918533325195, 0.27840712666511536, -0.1214492991566658, -0.3467295467853546, 0.46944019198417664, -0.053946878761053085, -0.3057156503200531, -0.3313996195793152, 0.014300289563834667, -0.3638695478439331, 0.19051572680473328, -5.975093841552734, -0.07493072748184204, -0.4686468243598938, 0.034741420298814774, -0.30333465337753296, -0.13302405178546906, 1.0843716859817505, -0.46602416038513184, -0.1284370869398117, 0.14812254905700684, 0.11013834923505783, 0.3530120849609375, 0.2595668435096741, 0.0420861691236496, 0.06918895244598389, 0.5151414275169373, 0.08112809807062149, -0.1826699823141098, 0.5396978855133057, 0.308916300535202, 0.30862608551979065, -0.32797592878341675, -0.29329052567481995, 0.6196070909500122, 0.18834036588668823, 0.4923970401287079, -0.6297275424003601, 0.3558814823627472, -0.2960961163043976, -0.26120027899742126, 0.023591764271259308, -0.5641516447067261, -0.48869064450263977, -0.1568787693977356, 0.7496402859687805, 0.029489006847143173, 0.43573951721191406, 0.3715904653072357, 0.08513864129781723, -0.3012409806251526, 0.006887616124004126, 0.16164065897464752, -0.10568610578775406, -0.16490459442138672, 0.16779905557632446, 0.19169621169567108, -0.04920649155974388, 0.08340663462877274, -0.6845341920852661, 0.8966469168663025, 0.32510513067245483, -0.2597571611404419, 0.21441607177257538, 0.318994402885437, 0.30133751034736633, -0.33340802788734436, 0.14831146597862244, 0.247636616230011, -0.23990188539028168, 0.35901153087615967, -0.08085325360298157, -0.15838980674743652, 0.17692622542381287, -1.079310417175293, -0.19831809401512146, 0.1191977858543396, -0.6908366084098816, -0.18675795197486877, 0.02420707419514656, -0.12947022914886475, -0.3621951937675476, 0.17493382096290588, 0.23458823561668396, -0.7038427591323853, 0.33408647775650024, -0.27649521827697754, 0.24218159914016724, 0.3469310402870178, 0.07826771587133408, -0.20494167506694794, -0.1851014345884323, 0.040983572602272034, 0.007036485243588686, -0.36907321214675903, 0.33381667733192444, -0.24644732475280762, -0.3103716969490051, 0.18981440365314484, -0.06139294430613518, 0.12836889922618866, -0.08778795599937439, -0.08881596475839615, 0.19238434731960297, 0.841640055179596, 0.19561263918876648, 0.84832364320755, 0.5629638433456421, 0.40120095014572144, 0.10200069844722748, -0.09472615271806717, 0.5000372529029846, -0.20161792635917664, -0.3500194549560547, -0.5728819370269775, -0.07746972143650055, 0.3455543518066406, -0.7560221552848816, 0.046435415744781494, 0.8334603309631348, -0.7775523662567139, 0.10933058708906174, -0.06784763932228088, -0.31533870100975037, -0.7064963579177856, 0.44929343461990356, -0.36328989267349243, -0.2854633033275604, 0.21869628131389618, 0.6292949318885803, -0.1449155956506729, 0.12471833825111389, 0.28945642709732056, -0.43617022037506104, 0.05868439003825188, 0.15177740156650543, 0.24505071341991425, 0.2403239905834198, 0.6032294034957886, -0.5542363524436951, 0.06094830855727196, 0.27949094772338867, 0.39100968837738037, -0.4818359315395355, 0.06887423992156982, 0.04436390846967697, -0.5756517648696899, -0.06975188851356506, 0.31345438957214355, 0.01690652221441269, -0.27281877398490906, 0.4856211841106415, 0.11469235271215439, -0.420297235250473, 0.20763739943504333, 0.04514024034142494, -0.05259348824620247, -0.3363093137741089, -0.1255359649658203, -0.28006598353385925, 0.15599001944065094, 0.08472725749015808, -0.0037570721469819546, 0.06034761667251587, -0.021604912355542183, -0.21142049133777618, 0.4833306670188904, 0.3011821508407593, 0.2001248151063919, -0.11932728439569473, -0.6709797978401184, 0.42298802733421326, -0.29571983218193054, -1.3230266571044922, -0.46926695108413696, 0.1657055914402008, -0.11501437425613403, -0.4158346951007843, -0.0157986618578434, 0.07638433575630188, 0.4311104118824005, -0.23063690960407257, -0.5993596911430359, -0.14712433516979218, -0.017365500330924988, 0.26910024881362915, -0.026468586176633835, -0.1167830154299736, 0.4114270806312561, -0.12043158710002899, 0.007506766356527805, 0.08538512140512466, -0.6164618134498596, -0.23058897256851196, 0.05880040302872658, 0.5890643000602722, 0.4978253245353699, 0.12054567784070969, 0.12425737828016281, -0.34858810901641846, -0.14505808055400848, 0.1417543888092041, 0.20669779181480408, 0.2893613278865814, 0.13761599361896515, 0.034656822681427, -0.3999844789505005, 0.15538790822029114, 0.1302790492773056, -0.025339584797620773, -0.17581525444984436, 0.12687884271144867, 0.4121895432472229, -0.2547423839569092, 0.3048248589038849, 0.6281290054321289, -0.1380573958158493, 0.18016241490840912, -0.18784120678901672, -0.40936851501464844, 0.02286231890320778, -0.5047284960746765, -0.23920999467372894, -0.3713202178478241, 0.40457385778427124, -0.4522712230682373, -0.12247081845998764, 0.2706266939640045, -0.19045081734657288, -0.2911543846130371, 0.23189777135849, 0.47732752561569214, -0.3457803428173065, -0.5373274683952332, 0.022540848702192307, -0.38039228320121765, -0.1185939610004425, 0.6129119396209717, -0.690657913684845, 0.15460607409477234, 0.3773477375507355, -0.6234793663024902, -0.11305084824562073, -0.0406336635351181, 0.2287616729736328, -0.025816496461629868, -0.20644237101078033, 0.05304484814405441, 0.5771737694740295, -0.0072087193839251995, 0.18757151067256927, 0.0374283529818058, 0.9382357597351074, -0.3423251211643219, -0.2949586510658264, -0.023596111685037613, -0.15832634270191193, 0.20269501209259033, -0.7969812750816345, -0.40761059522628784, -0.07500006258487701, 0.22958996891975403, -0.15917153656482697, 0.2948203980922699, 0.20316080749034882, 0.9593193531036377, 0.23404869437217712, -0.4841788113117218, -0.7138985991477966, 0.27820074558258057, 0.43038517236709595, 0.05092155188322067, -0.1502961367368698, 0.012469039298593998, -0.36736857891082764, 0.30788397789001465, 0.3565465211868286, -0.47802478075027466, -0.32584670186042786, 0.18336984515190125, -0.5869326591491699, 0.30359208583831787, -0.0854581668972969, 0.3349204957485199, 0.16104035079479218, 0.06763476878404617, 0.16604092717170715, -0.18883013725280762, -0.4683067202568054, 0.017792928963899612, 0.4094589948654175, -0.09197380393743515, -0.7382797002792358, 0.27533650398254395, -0.1075630635023117, 0.36366981267929077, -0.49300244450569153, -0.06645695120096207, -0.3125438690185547, -0.19294944405555725, -0.3658715784549713, -0.2181464582681656, 0.12362600117921829, -0.6538370251655579, -0.18800656497478485, 0.11640960723161697, -0.06384119391441345, 0.706524133682251, 0.39560848474502563, -0.21100957691669464, -0.09880132973194122, -0.13468660414218903, 0.5287730693817139, 0.3196464776992798, -0.32313787937164307, 0.2887716293334961, 0.23591348528862, -0.029627647250890732, -0.3679400384426117, 0.12516231834888458, -0.0004122308164369315, 0.27067896723747253, -0.21285834908485413, 0.33104756474494934, 0.36699527502059937, -0.4125000536441803, -0.17961494624614716, -0.1083759292960167, -0.09646061807870865, 0.5931390523910522, 0.23126938939094543, 0.08960843086242676, 0.5418028235435486, 0.642218828201294, -0.18638354539871216, -0.08953139930963516, 0.6263708472251892, 0.15184515714645386, 0.2497299313545227, 0.23158389329910278, 0.3918544054031372, 0.5725831985473633, 1.043502926826477, -0.20446404814720154, 0.5061492919921875, 0.39953526854515076, 0.4296312630176544, -0.08080363273620605, -0.23283341526985168, -0.39226847887039185, -0.04444346949458122, 0.8369714617729187, -0.058896925300359726, -0.3908930718898773, -0.14119437336921692, -0.09706983715295792, 0.680307149887085, 0.015294434502720833, 0.2096983641386032, -0.05208098888397217, 0.2938728928565979, 0.337085098028183, -0.02908977121114731, -0.100779689848423, 0.09430897235870361, -0.513070821762085, 0.07691100984811783, 0.2588307857513428, -0.6008623838424683, -0.8787016868591309, 0.23377841711044312, 0.06510677188634872, -0.06991280615329742, -0.4468914866447449, 0.20346271991729736, -0.21093830466270447, -0.13199220597743988, 0.522091805934906, 0.05003589019179344, 0.14429618418216705, 0.12060292065143585, -0.2034798562526703, 0.06743201613426208, -0.48926421999931335, 0.2186468094587326, -0.163264200091362, -0.5102707743644714, 0.14926855266094208, 0.15880820155143738, 0.11882026493549347, 0.1668606549501419, -0.29072755575180054, 0.03306439518928528, -0.2523406445980072, -0.44106927514076233, 0.15388816595077515, -0.30364853143692017, -0.09745609760284424, 0.08232609182596207, 0.3447926938533783, 0.44762665033340454, 0.019815461710095406, -0.6121949553489685, -0.14988885819911957, 0.06418461352586746, 0.1271519660949707, 0.09181641787290573, -0.5143890380859375, 0.37176430225372314, 0.44863536953926086, 0.08689692616462708, -0.6532627940177917, -0.16699917614459991, -0.3581085503101349, 0.41815757751464844, -0.22736544907093048, 0.6695016026496887, -0.29650816321372986, -0.2535693645477295, -0.4950563609600067, -0.04865734651684761, 0.6228062510490417, 0.14065256714820862, -0.05617322027683258, 0.16962407529354095, -0.05052124336361885, 0.3150738775730133, 0.5118234753608704, -0.4945116937160492, -0.37260857224464417, -0.3794853687286377, -0.27714601159095764, -0.35781779885292053, 1.0257707834243774, -0.09927497059106827, -0.26509004831314087, -0.258023202419281, 0.23789753019809723, -0.011283786036074162, -0.18003404140472412, 0.6635175943374634, -0.28954756259918213, 0.013643904589116573, -0.6310644745826721, 0.11718377470970154, -0.8743617534637451, 0.14298754930496216, 0.4761733412742615, 0.09705667942762375, 0.06547270715236664, 0.036576032638549805, -0.07526830583810806, -0.6620357632637024, 0.02464727871119976, 0.6411365270614624, -0.12248758226633072, 0.3688594698905945, 0.014545253477990627, -0.408733069896698, -0.6009970903396606, 0.22717534005641937, -0.04671984165906906, -0.17964716255664825, -0.6230866312980652, -0.40942907333374023, -0.5127698183059692, 0.01963132992386818, 0.197969451546669, -0.5035167336463928, -0.060044728219509125, -0.00895930640399456 ]
AIMS Recent evidence suggests that cardiac progenitor cells (CPCs) may improve cardiac function after injury. The underlying mechanisms are indirect, but their mediators remain unidentified. Exosomes and other secreted membrane vesicles, hereafter collectively referred to as extracellular vesicles (EVs), act as paracrine signalling mediators. Here, we report that EVs secreted by human CPCs are crucial cardioprotective agents. METHODS AND RESULTS CPCs were derived from atrial appendage explants from patients who underwent heart valve surgery. CPC-conditioned medium (CM) inhibited apoptosis in mouse HL-1 cardiomyocytic cells, while enhancing tube formation in human umbilical vein endothelial cells. These effects were abrogated by depleting CM of EVs. They were reproduced by EVs secreted by CPCs, but not by those secreted by human dermal fibroblasts. Transmission electron microscopy and nanoparticle tracking analysis showed most EVs to be 30-90 nm in diameter, the size of exosomes, although smaller and larger vesicles were also present. MicroRNAs most highly enriched in EVs secreted by CPCs compared with fibroblasts included miR-210, miR-132, and miR-146a-3p. miR-210 down-regulated its known targets, ephrin A3 and PTP1b, inhibiting apoptosis in cardiomyocytic cells. miR-132 down-regulated its target, RasGAP-p120, enhancing tube formation in endothelial cells. Infarcted hearts injected with EVs from CPCs, but not from fibroblasts, exhibited less cardiomyocyte apoptosis, enhanced angiogenesis, and improved LV ejection fraction (0.8 ± 6.8 vs. -21.3 ± 4.5%; P < 0.05) compared with those injected with control medium. CONCLUSION EVs are the active component of the paracrine secretion by human CPCs. As a cell-free approach, EVs could circumvent many of the limitations of cell transplantation.
[ 0.00728252250701189, 0.009337414056062698, -0.011612603440880775, 0.026126381009817123, -0.018642375245690346, -0.01711646094918251, 0.011968234553933144, -0.018704112619161606, -0.01153767853975296, -0.023228276520967484, 0.001629486447200179, 0.019409291446208954, 0.018913760781288147, 0.021551575511693954, 0.0054817358031868935, 0.009783003479242325, -0.0023764860816299915, 0.00750700244680047, 0.009917551651597023, -0.013674858957529068, 0.0018380498513579369, -0.0005238177836872637, 0.011963492259383202, -0.026873044669628143, 0.026917047798633575, 0.01818184182047844, 0.031818799674510956, -0.0040551479905843735, -0.010116687044501305, -0.010385410860180855, 0.011480987071990967, 0.004587450996041298, 0.0015937760472297668, -0.03270087018609047, 0.005111284088343382, -0.03526828810572624, -0.007974768057465553, 0.036357805132865906, 0.037778835743665695, -0.005314179230481386, 0.007512114942073822, -0.005576745141297579, 0.002535413485020399, -0.006779547780752182, -0.010767300613224506, 0.03269040584564209, 0.000576761260163039, 0.021060608327388763, -0.023038305342197418, 0.006515047047287226, 0.0068578897044062614, 0.004464248660951853, -0.01933271810412407, 0.001995450584217906, -0.007135618478059769, -0.018767662346363068, 0.020883118733763695, -0.01962260901927948, -0.015202096663415432, -0.022937385365366936, 0.004432159475982189, -0.012031525373458862, -0.015095383860170841, -0.04446989297866821, -0.016451239585876465, -0.06656330823898315, -0.010135510936379433, -0.006511431187391281, -0.019098931923508644, 0.007207663729786873, 0.025788171216845512, 0.007356384769082069, -0.0097502451390028, 0.010099519044160843, 0.007077628746628761, -0.02705685794353485, -0.0066193947568535805, 0.010809127241373062, 0.0032160524278879166, 0.0045816292986273766, -0.027822239324450493, -0.023218106478452682, -0.02946298196911812, 0.0044746119529008865, 0.01060726772993803, 0.020454715937376022, -0.021258272230625153, 0.03500301018357277, 0.0005273371934890747, -0.00509549118578434, -0.0034212195314466953, 0.020253943279385567, -0.017295777797698975, -0.008435467258095741, -0.0039960406720638275, 0.017173465341329575, -0.02115315943956375, -0.0032653971575200558, -0.051918674260377884, 0.0033145698253065348, -0.011425045318901539, 0.0038079028017818928, 0.0220568235963583, 0.01361768040806055, -0.024203864857554436, 0.011351026594638824, 0.0025005307979881763, -0.014725333079695702, 0.014575314708054066, 0.01824352890253067, -0.003277999348938465, 0.005497797392308712, 0.011724165640771389, 0.03651365637779236, 0.02634543552994728, -0.0028849169611930847, 0.034559465944767, 0.01890791393816471, 0.0226135216653347, 0.039280857890844345, -0.027344562113285065, 0.02011907286942005, 0.010014403611421585, 0.0175410658121109, 0.008549883030354977, 0.0016035139560699463, 0.0002670153044164181, 0.015275025740265846, 0.0012750031892210245, 0.008583204820752144, -0.012527547776699066, 0.0020402437075972557, 0.010247667320072651, 0.017458219081163406, 0.0357283391058445, -0.003878808580338955, 0.007087335921823978, 0.000010972842574119568, -0.002729808446019888, -0.03088996559381485, 0.012658041901886463, 0.009354155510663986, 0.003004698548465967, 0.022671382874250412, 0.03040378913283348, 0.0015215801540762186, -0.015443293377757072, 0.001756402663886547, -0.016836347058415413, -0.02388863079249859, -0.0008301027119159698, -0.015058466233313084, -0.007929423823952675, -0.02749866619706154, 0.010633779689669609, -0.007148630917072296, -0.008792663924396038, -0.0019526854157447815, 0.00878120493143797, 0.019694924354553223, -0.09145312011241913, -0.025948720052838326, 0.01766446977853775, 0.011856336146593094, -0.02202300727367401, -0.009717399254441261, 0.007915031164884567, 0.002814376726746559, -0.03560387343168259, 0.009695921093225479, -0.0035365421790629625, 0.008297119289636612, 0.0014612262602895498, 0.008113453164696693, 0.023253217339515686, -0.0006720810197293758, 0.019622985273599625, 0.011604887433350086, -0.028867028653621674, 0.06677841395139694, -0.00966862216591835, 0.031337201595306396, 0.0308084599673748, -0.00963936559855938, -0.00885066855698824, -0.03028077632188797, 0.006647014990448952, -0.009638200514018536, 0.014485815539956093, -0.047460295259952545, -0.027950545772910118, 0.02627364732325077, -0.04059481993317604, 0.009130001068115234, -0.010087012313306332, 0.0038624233566224575, -0.007084605284035206, 0.012105618603527546, -0.01745440997183323, -0.02129434235394001, 0.003477672813460231, -0.04087007790803909, 0.0006507020443677902, 0.0021238690242171288, 0.01891232281923294, 0.027207788079977036, -0.01044086366891861, -0.025700422003865242, -0.00448455847799778, 0.022662751376628876, 0.022522522136569023, -0.02225673384964466, 0.0056383321061730385, 0.015331609174609184, 0.014004644937813282, 0.0005598310963250697, 0.0007000325713306665, -0.016901176422834396, 0.007216962985694408, -0.012118740007281303, -0.0112626813352108, 0.005028542131185532, 0.022535402327775955, 0.020916633307933807, 0.02322554588317871, 0.011540799401700497, 0.01236734725534916, 0.012774161994457245, 0.011651542969048023, 0.008789791725575924, -0.018720412626862526, -0.022704413160681725, -0.017386211082339287, 0.006424715742468834, 0.022835351526737213, 0.010289485566318035, 0.01685451529920101, -0.03349188715219498, -0.00018089331570081413, -0.0105698611587286, -0.008284437470138073, -0.0035219776909798384, 0.013817538507282734, -0.02074834331870079, 0.017987536266446114, 0.009530884213745594, 0.034108471125364304, -0.008792189881205559, 0.02872784249484539, -0.02412712760269642, 0.011762382462620735, 0.0091397138312459, 0.0010890820994973183, -0.0133156543597579, 0.015863435342907906, -0.015683291479945183, -0.023816775530576706, -0.0028760689310729504, 0.023684490472078323, 0.0021029324270784855, -0.0004033180885016918, 0.011362703517079353, -0.0007597655057907104, 0.009311780333518982, -0.01667311228811741, 0.009515217505395412, -0.010415548458695412, 0.005384813994169235, 0.0028283442370593548, -0.010945010930299759, 0.015922119840979576, 0.0005202827742323279, -0.0031775152310729027, -0.08052580058574677, -0.014200426638126373, -0.004712924361228943, -0.022038618102669716, 0.007804134860634804, 0.009403967298567295, 0.027825376018881798, 0.010377215221524239, -0.00849694013595581, -0.014461779966950417, -0.03073403239250183, 0.006125550251454115, -0.01906592771410942, 0.03184633329510689, -0.015141693875193596, -0.013284302316606045, 0.013403449207544327, 0.00920297671109438, -0.020481346175074577, -0.019417274743318558, 0.017423324286937714, 0.022857803851366043, -0.0007120640948414803, -0.008329218253493309, -0.01788054034113884, 0.018392512574791908, -0.0023540975525975227, 0.01785050705075264, 0.0028023989871144295, 0.007169215939939022, -0.012590409256517887, -0.004272511228919029, 0.03285916894674301, -0.0176544152200222, -0.006360667757689953, 0.019513137638568878, 0.017012912780046463, 0.017063336446881294, -0.018398582935333252, 0.024660855531692505, -0.007089422084391117, 0.036593250930309296, 0.02611725404858589, 0.011621944606304169, 0.01354079321026802, 0.007235467899590731, 0.032908327877521515, -0.006342584267258644, 0.017923414707183838, 0.014013653621077538, -0.036855537444353104, -0.0021014357917010784, 0.025049690157175064, 0.018744638189673424, -0.02334837056696415, 0.0015558172017335892, -0.03338257223367691, 0.01903599314391613, -0.015980474650859833, -0.008582036942243576, -0.03529088944196701, 0.015264025889337063, 0.011054493486881256, 0.010263403877615929, 0.004806936718523502, 0.026142682880163193, 0.014391236007213593, -0.002493596635758877, -0.004384071100503206, -0.005716546438634396, 0.02959348075091839, -0.012883582152426243, -0.030137425288558006, -0.013201504945755005, -0.012736404314637184, -0.011348707601428032, -0.01208757609128952, -0.011049440130591393, -0.020355166867375374, -0.027867965400218964, -0.041369177401065826, -0.0017973138019442558, 0.0005674937274307013, -0.007360702380537987, -0.03573009371757507, -0.03234706073999405, 0.009626543149352074, 0.0469014048576355, 0.014330574311316013, -0.01589946448802948, -0.008558657020330429, 0.022074639797210693, 0.0005995358806103468, 0.006541348993778229, -0.008881093934178352, -0.03607602417469025, 0.01900261640548706, -0.01273808628320694, 0.03425179049372673, 0.010234628804028034, -0.03463689982891083, 0.013428266160190105, -0.009425388649106026, -0.015487109310925007, -0.021058155223727226, 0.016131600365042686, 0.014968778006732464, 0.0004133055917918682, -0.005957797635346651, -0.0055667925626039505, -0.0438481941819191, -0.022753924131393433, -0.004101283848285675, -0.030382350087165833, 0.014906546100974083, 0.009923780336976051, -0.00013381848111748695, 0.009132340550422668, 0.07164931297302246, -0.003832632675766945, -0.004841003566980362, -0.0017805194947868586, 0.01434694416821003, -0.04399001598358154, -0.027005348354578018, -0.01311528030782938, 0.012345862574875355, 0.012858550064265728, 0.012536941096186638, -0.030903615057468414, 0.012056314386427402, -0.016682539135217667, -0.08489300310611725, -0.021629925817251205, 0.004257303196936846, -0.03955048322677612, -0.02021714672446251, 0.009576630778610706, -0.0037173712626099586, -0.027507251128554344, 0.0132587356492877, -0.0035324012860655785, -0.008140148594975471, -0.0066289277747273445, 0.005760320462286472, -0.013877185061573982, -0.016326487064361572, 0.019035637378692627, -0.0030976843554526567, -0.017688259482383728, -0.010225990787148476, 0.004379682242870331, 0.03715704753994942, -0.02636292204260826, -0.008870071731507778, 0.0023990999907255173, -0.006541606970131397, 0.03252999112010002, -0.015619373880326748, -0.011010309681296349, 0.0003178357146680355, 0.017064401879906654, 0.013823753222823143, -0.027231484651565552, 0.024472367018461227, -0.012774907052516937, 0.001703017856925726, -0.018210265785455704, -0.020393893122673035, 0.013598395511507988, 0.01630779728293419, 0.020783977583050728, -0.01682158187031746, -0.012292957864701748, 0.007977863773703575, 0.001261536730453372, -0.007795857265591621, 0.02883727476000786, -0.008655566722154617, 0.010373450815677643, 0.001538967713713646, -0.0009198999032378197, -0.01065527368336916, -0.0028073247522115707, 0.012559332884848118, 0.004571670666337013, -0.020683052018284798, -0.007148634176701307, -0.03214554116129875, 0.029886681586503983, -0.014141879975795746, 0.014185957610607147, -0.0032962942495942116, -0.0347130186855793, 0.016837388277053833, 0.029793839901685715, 0.01096965093165636, -0.00017083296552300453, 0.004919464234262705, 0.009742466732859612, 0.0013475343585014343, -0.023807832971215248, -0.010636834427714348, -0.0009272834286093712, -0.0008565692696720362, -0.07342922687530518, -0.01770111545920372, -0.009709717705845833, -0.007848910987377167, 0.02314445562660694, 0.0061620865017175674, -0.015666447579860687, 0.014177976176142693, 0.006264576688408852, -0.0057023451663553715, 0.024778399616479874, 0.023938864469528198, 0.009451117366552353, -0.004368821159005165, 0.014603378251194954, 0.013231232762336731, 0.02076324261724949, 0.0028764531016349792, -0.010062845423817635, -0.019563691690564156, -0.002599848434329033, -0.014913407154381275, -0.009605099447071552, -0.012128216214478016, 0.0036938460543751717, -0.08020524680614471, -0.017563100904226303, 0.02342412620782852, -0.010141215287148952, -0.011503560468554497, 0.0025519495829939842, -0.0033364463597536087, 0.0037316707894206047, -0.0008592656813561916, -0.015957383438944817, 0.025270234793424606, 0.019680654630064964, 0.01570121757686138, 0.004592232406139374, 0.0006775096990168095, -0.0082841906696558, 0.02321454882621765, -0.0008041318506002426, -0.009318925440311432, -0.00953085906803608, 0.016196463257074356, 0.0060762083157896996, -0.014727970585227013, -0.006523876916617155, -0.011723777279257774, -0.03985434025526047, 0.0009378772228956223, 0.01968996413052082, 0.023622123524546623, -0.023515649139881134, -0.023803655058145523, 0.01705050654709339, -0.026568420231342316, -0.006938018836081028, 0.0024354804772883654, -0.029331743717193604, -0.003670118749141693, 0.01734636351466179, -0.03420513868331909, -0.019344646483659744, -0.009384451434016228, -0.01647818833589554, -0.016539564356207848, -0.0017556091770529747, -0.0033379807136952877, -0.012045202776789665, 0.007018572650849819, -0.009555202908813953, 0.012877603061497211, -0.03165972977876663, 0.010335271246731281, 0.011754135601222515, 0.0002049152972176671, -0.005439942702651024, 0.024080876260995865, 0.0229788888245821, -0.0009851817740127444, -0.003919300623238087, 0.0007929522544145584, -0.009725645184516907, 0.005596335045993328, 0.012704660184681416, -0.014310742728412151, 0.07153439521789551, 0.022024862468242645, 0.0256818775087595, -0.0053834011778235435, -0.02531316503882408, 0.006122290622442961, 0.009248084388673306, -0.022138256579637527, -0.0007509246934205294, -0.00639631412923336, 0.05227018892765045, 0.00020390457939356565, 0.002268953248858452, 0.019636381417512894, -0.003126580500975251, -0.006809101440012455, 0.005963511299341917, 0.008627261966466904, 0.03009689226746559, 0.047043099999427795, -0.021992862224578857, -0.027138039469718933, -0.008168013766407967, -0.0011102503631263971, 0.030753521248698235, 0.013111231848597527, 0.016512960195541382, 0.02431783452630043, 0.023544451221823692, 0.001520243939012289, 0.014126289635896683, -0.013645648956298828, 0.0021602774504572153, 0.0005871700122952461, 0.019908227026462555, -0.0009726379066705704, -0.017296161502599716, 0.005935439839959145, -0.018244296312332153, 0.04117932170629501, 0.015366807579994202, 0.005029068328440189, 0.0019445447251200676, 0.003462914377450943, -0.003803510218858719, 0.005884700454771519, 0.023662783205509186, -0.03893083333969116, 0.023647913709282875, 0.0047161635011434555, 0.032062359154224396, 0.0008510524057783186, -0.011701417155563831, -0.02347816899418831, 0.008338683284819126, -0.03365938737988472, -0.0014892835170030594, 0.023307038471102715, 0.004680361598730087, 0.011880755424499512, 0.0059182411059737206, -0.0176454558968544, 0.026314347982406616, -0.012732965871691704, 0.01029716432094574, -0.0012256260961294174, 0.005276096984744072, -0.005318797193467617, -0.016842665150761604, 0.023691609501838684, 0.011757159605622292, -0.02160286344587803, 0.016175437718629837, 0.015012387186288834, 0.002250082092359662, 0.020087430253624916, -0.0028656236827373505, 0.016805170103907585, 0.010568952187895775, 0.026378842070698738, -0.026710662990808487, -0.004759536124765873, -0.022757168859243393, 0.027866171672940254, -0.015293989330530167, 0.03690342977643013, -0.008171087130904198, 0.012841848656535149, -0.0062730819918215275, 0.01946403458714485, 0.040528371930122375, -0.006506094243377447, 0.003674929030239582, 0.03749784082174301, 0.011953668668866158, 0.033366888761520386, 0.0004589594900608063, -0.007418379653245211, 0.022893939167261124, 0.008381896652281284, 0.02407148852944374, 0.035907991230487823, -0.03302188217639923, 0.012990581803023815, -0.0005898484960198402, -0.00871581956744194, -0.020487498492002487, 0.007567783817648888, -0.012340654619038105, 0.007541017606854439, 0.0059585534036159515, -0.041880615055561066, -0.0013892198912799358, 0.025689542293548584, 0.03236285597085953, -0.002820036606863141, -0.023695483803749084, 0.06118389219045639, -0.017217488959431648, -0.01477501355111599, 0.0014969989424571395, -0.0051609487272799015, -0.0003604637458920479, 0.013139346614480019, -0.02534685656428337, -0.043941497802734375, -0.01595381833612919, 0.0139924893155694, 0.014994058758020401, 0.0002802833914756775, 0.01793602854013443, 0.022382941097021103, 0.005725733004510403, 0.019395262002944946, -0.005065469536930323, -0.010612335056066513, -0.01077691838145256, 0.017883172258734703, -0.03190638870000839, -0.002467675134539604, 0.011181739158928394, -0.037100911140441895, -0.0020568370819091797, 0.016080893576145172, 0.008192729204893112, -0.029758449643850327, 0.0025998828932642937, 0.007938426919281483, 0.009458305314183235, 0.04019101709127426, 0.00670122355222702, 0.0030454364605247974, -0.007750785909593105, -0.008892935700714588, 0.02266400121152401, 0.02982652187347412, 0.011967288330197334, 0.012156382203102112, -0.011403340846300125, -0.0037634328473359346, 0.001789996400475502, 0.015647608786821365, 0.008536886423826218, 0.0008164162281900644, 0.02209055796265602, -0.002839125692844391, -0.03767719864845276, -0.011927184648811817, -0.008361275307834148, -0.04031450301408768, 0.03245634585618973, 0.025480221956968307, -0.05960862711071968, 0.031005756929516792, -0.05000097304582596, -0.012068483978509903, 0.008652829565107822, 0.01332218199968338, 0.05303765833377838, 0.005412166006863117, 0.006283142603933811, -0.054742857813835144, 0.017929788678884506, -0.005996274761855602, -0.019553665071725845, -0.005100902635604143, -0.017796695232391357, -0.02538934536278248, -0.00441453792154789, 0.03142315149307251, -0.01965317688882351, -0.006240139249712229, -0.00984376110136509, 0.006834110245108604, -0.028952190652489662, -0.014000721275806427, 0.04066390171647072, -0.03739849478006363, 0.010658247396349907, 0.01995771750807762, -0.009718043729662895, -0.006593513768166304 ]
[ 0.34254124760627747, -0.10956817120313644, 0.4469276964664459, 0.21437054872512817, -0.08536884188652039, -0.16969671845436096, -0.12052468955516815, -0.42798420786857605, -0.24986585974693298, -0.23597177863121033, -0.07874903827905655, 0.20211486518383026, -0.1731317639350891, -0.28158506751060486, 0.1227225586771965, 0.18582583963871002, 0.41119635105133057, 0.5396497845649719, -0.4527069330215454, -0.5360546112060547, -0.40804362297058105, -0.1044221967458725, 0.41626158356666565, -0.11714914441108704, 0.10377691686153412, 0.3692948520183563, 0.20510059595108032, -0.5386772155761719, 0.23303869366645813, -0.6433987021446228, 0.18848322331905365, 0.19089275598526, 0.06364616751670837, -0.257736474275589, -0.3091162145137787, 0.21240679919719696, -0.741553783416748, 0.0518316887319088, -0.3996969163417816, -0.6672519445419312, -0.8383998870849609, -0.7601628303527832, -0.05815060809254646, 0.3837539851665497, -0.32847923040390015, -0.4625774621963501, -1.1824671030044556, 0.31166374683380127, -0.34604716300964355, 0.40191593766212463, 0.46930962800979614, 0.1301879584789276, 0.11509552597999573, 0.22184327244758606, 0.37111014127731323, -0.06908758729696274, -0.658656656742096, -0.2428485006093979, 0.0701800212264061, -0.7962990999221802, -0.23611579835414886, -0.03930199518799782, -0.3024500012397766, 0.4714551866054535, 0.0293804369866848, 0.5496315360069275, 0.010406533256173134, -0.22382374107837677, -0.1935727298259735, -0.48499777913093567, 0.1842329204082489, -0.3980605900287628, -0.11062682420015335, 0.27891823649406433, -0.12857529520988464, -0.42969879508018494, -0.10030541568994522, -0.23456230759620667, 0.4619658589363098, 0.6109009385108948, 0.16880850493907928, 0.3182595670223236, 0.1602654606103897, 0.0005807031411677599, 0.4573914110660553, 0.09318441152572632, -0.1991870254278183, 0.3435819447040558, -0.1349441260099411, -0.0021614462602883577, 0.13180969655513763, 0.38134506344795227, 0.6283692121505737, 0.3441801071166992, 0.07001477479934692, 0.46009665727615356, 0.27234894037246704, -0.5206728577613831, 0.0026529040187597275, 0.4965460002422333, -0.26089850068092346, -0.06707099080085754, -0.2603832483291626, -0.7682955265045166, -0.1257549524307251, 0.3449929654598236, -0.4242105782032013, -0.7706912755966187, -0.9431607723236084, 0.17549651861190796, -0.8567657470703125, 0.036643579602241516, -0.072864830493927, -0.1776668131351471, -0.14301256835460663, -0.21577683091163635, 0.37331143021583557, 0.10239814966917038, 0.3401359021663666, 0.2227819263935089, 0.549759566783905, 1.2403950691223145, 0.04984137415885925, 0.06407573074102402, 0.1279085874557495, 0.1493595838546753, 0.38767939805984497, 0.2612802982330322, -0.0432594008743763, 0.717853844165802, -0.045203495770692825, 0.7704769968986511, -0.19709528982639313, -0.18533051013946533, -0.18682800233364105, 0.2218521237373352, 0.5530627965927124, 0.3532746136188507, 0.14699341356754303, 0.3267401456832886, -0.568998396396637, -0.46856850385665894, 0.24500946700572968, 0.09145611524581909, -0.07281026244163513, -0.2885057032108307, -0.4175257980823517, 0.2691704332828522, -0.27796193957328796, -0.125208780169487, 0.031197892501950264, -0.40158379077911377, -0.15092524886131287, -0.001986296847462654, -0.03746511787176132, 0.7935290336608887, 0.2633209228515625, -0.19154435396194458, 0.12885791063308716, 0.05697157606482506, 0.1853819638490677, 0.06887976080179214, -0.5019868612289429, -0.03370627388358116, 0.34685856103897095, 0.26722073554992676, 0.07494933158159256, 0.46941080689430237, 0.3239854872226715, 0.03682699427008629, -0.25491568446159363, -0.5482750535011292, 0.04083126783370972, -0.42938145995140076, -0.1834750771522522, -0.3030296266078949, 0.21182599663734436, 0.20666776597499847, -0.2124251127243042, 0.35109323263168335, -0.8919684290885925, 0.15445704758167267, -0.3564457595348358, -1.0785061120986938, 0.2610006630420685, 0.2014722377061844, 0.40683111548423767, -0.2476228028535843, -0.0032929268199950457, 0.4265527129173279, -0.1444057673215866, 0.05042989179491997, -0.020527983084321022, -0.9614434838294983, 1.5729284286499023, -0.722597062587738, -0.07847080379724503, 1.040014386177063, -0.1060836985707283, -0.07400116324424744, 0.10562680661678314, 0.34560251235961914, 0.5849205851554871, -0.1614077091217041, -0.7469868659973145, 0.07344039529561996, 0.3219940960407257, 0.2654688358306885, -0.24546675384044647, 0.09735431522130966, 0.3956836760044098, -0.27319175004959106, 0.187151238322258, -0.6273661255836487, 0.2844146490097046, -0.46381860971450806, -0.22005094587802887, -0.13401120901107788, -0.3708242177963257, 0.26014673709869385, 0.49106284976005554, -0.6836374402046204, 0.6801373362541199, 1.119463324546814, -0.06953397393226624, 0.5481008291244507, 0.8498263955116272, 0.19065973162651062, 0.610537588596344, -0.37843939661979675, 0.3668347895145416, -0.246523916721344, 0.06760764867067337, -0.46168023347854614, -0.2809092402458191, -0.11347152292728424, 0.2269776165485382, -0.45293521881103516, 0.06736475974321365, 0.04411269351840019, -0.10771786421537399, 0.2743566632270813, -0.3511529266834259, 0.03920259326696396, 0.3101944923400879, -0.2713087499141693, -0.3775447905063629, 0.09711002558469772, -0.6269493103027344, -0.058559224009513855, -0.14843496680259705, 0.5484270453453064, 0.30233868956565857, -0.16904690861701965, 0.6361436247825623, 0.3656783998012543, -0.12200120836496353, -0.07552941143512726, 0.10179311782121658, -0.06771168112754822, -0.29109427332878113, 0.03308025747537613, 0.19050247967243195, 0.25221681594848633, 0.10468688607215881, -0.37228623032569885, -0.053698066622018814, -0.11320210993289948, 0.8332584500312805, 0.9270410537719727, 0.8409804105758667, 0.0045134639367461205, -0.38753169775009155, 0.04058118537068367, -0.21249887347221375, -0.48439157009124756, 0.18284521996974945, 0.6257391571998596, -0.24318167567253113, -0.5272722244262695, -0.10179374366998672, 0.05182193964719772, 0.5017995834350586, -0.13893888890743256, 0.004059791564941406, -0.036399804055690765, -0.35699698328971863, -0.33536529541015625, -0.35726669430732727, -0.4491032063961029, -0.06041745841503143, 0.2585846185684204, 0.007183813955634832, -0.20511923730373383, 0.7670016884803772, 0.2810530364513397, 0.2541087865829468, 0.8217194080352783, 0.564629852771759, -0.02336611971259117, -0.3712892234325409, 0.2246391475200653, -0.2524372637271881, -0.16645152866840363, 0.02929895557463169, -0.14664198458194733, -0.17174488306045532, 0.42255452275276184, -5.877340793609619, -0.2241566926240921, -0.3768816292285919, 0.1987391859292984, -0.14496125280857086, 0.23132053017616272, 0.690997302532196, -0.020930644124746323, -0.1863669455051422, 0.2851274311542511, 0.21612276136875153, 0.7157249450683594, 0.04664015769958496, -0.006852883845567703, -0.14531417191028595, 0.1261749565601349, -0.343396931886673, -0.13142555952072144, 0.4932398498058319, -0.14776469767093658, 0.12952645123004913, -0.20540492236614227, 0.1721716970205307, 0.8460497856140137, 0.1581580638885498, -0.37317052483558655, -0.711561381816864, -0.004382144659757614, 0.02469644322991371, -0.23637206852436066, 0.08546655625104904, -0.31629741191864014, -0.14594274759292603, -0.41575902700424194, 0.3687992990016937, -0.06615250557661057, 0.5099634528160095, -0.3249762952327728, -0.11688274890184402, -0.5201294422149658, 0.2546788454055786, 0.09279050678014755, -0.21173395216464996, 0.2711077928543091, -0.20800139009952545, -0.46916377544403076, 0.11300640553236008, 0.45997023582458496, -0.5283994674682617, 0.7125316262245178, -0.027981098741292953, -0.13267727196216583, 0.16024357080459595, 0.28318068385124207, 0.44165873527526855, -0.027065865695476532, 0.10365729033946991, -0.04837564378976822, -0.6071319580078125, 0.37249770760536194, -0.12053469568490982, 0.13137459754943848, -0.39128756523132324, -0.6885656118392944, 0.1908407360315323, 0.5241194367408752, -0.6371288895606995, -0.8836380243301392, 0.40538567304611206, -0.2014865279197693, -0.46551406383514404, 0.24195444583892822, 0.07637433707714081, -0.8066838979721069, 0.19625848531723022, -0.18573148548603058, 0.4599432647228241, 0.22252917289733887, 0.01488315500319004, 0.5347836017608643, -0.3175629675388336, -0.06807700544595718, 0.07381382584571838, 0.058892883360385895, 0.004196210764348507, 0.12764349579811096, -0.15223273634910583, 0.0003829570487141609, 0.1407567709684372, 0.7308610677719116, 0.2880500853061676, -0.08923958986997604, 0.17592032253742218, 0.6317443251609802, 0.299667626619339, 0.17031827569007874, 0.24473173916339874, 0.20344266295433044, 0.36763522028923035, -0.10521282255649567, 0.1824180781841278, 0.5621387958526611, -0.47046205401420593, -0.9441108703613281, -0.4389471709728241, 0.0359320305287838, -0.9370782971382141, -0.0727318674325943, 0.5962974429130554, -0.878510057926178, 0.3207625150680542, -0.3014456629753113, -0.1830344796180725, -0.1560501903295517, 0.6497663855552673, 0.07679571211338043, 0.23931938409805298, 0.21297621726989746, 0.22724898159503937, -0.19433192908763885, 0.32419899106025696, 0.7430209517478943, -0.5850845575332642, 0.2523847818374634, -0.24665236473083496, -0.1848759651184082, 0.13085466623306274, 0.47288379073143005, -0.6551045179367065, -0.21020756661891937, 0.2812097370624542, 0.1868647336959839, -0.24014168977737427, 0.328428715467453, 0.3336579203605652, -0.27937865257263184, -0.29313188791275024, 0.3169863224029541, 0.21167346835136414, -0.3581737279891968, 0.2912997901439667, -0.20745471119880676, 0.03979846462607384, 0.2854771018028259, 0.742656946182251, -0.2139972597360611, -0.31358855962753296, 0.02809242345392704, 0.022300617769360542, -0.29205456376075745, 0.28690579533576965, -0.3193793296813965, 0.4712114930152893, 0.21257321536540985, -0.35636845231056213, 0.04293278977274895, 0.39039507508277893, -0.18212100863456726, 0.4962872862815857, -0.34514832496643066, 0.363598108291626, 0.4425002932548523, -0.9109587669372559, -0.37136703729629517, 0.2470749020576477, -0.45412036776542664, -0.32065218687057495, -0.43097347021102905, 0.017996903508901596, 0.041105154901742935, -0.036940962076187134, -0.25540053844451904, -0.42613035440444946, -0.24123339354991913, 0.08007724583148956, 0.08299015462398529, -0.3040285110473633, -0.027551235631108284, -0.02052987553179264, -0.2841150164604187, 0.059899888932704926, -0.6867471933364868, -0.1430630385875702, -0.012505849823355675, 0.9177373647689819, -0.05135934054851532, 0.05748853459954262, -0.7388443946838379, -0.13791072368621826, -0.15104563534259796, 0.021343931555747986, 0.4941064119338989, 0.33071237802505493, -0.10347680002450943, -0.04153971001505852, 0.14717407524585724, -0.08591064810752869, 0.39510685205459595, -0.1315767765045166, -0.5816166400909424, 0.22351804375648499, 0.03699522465467453, -0.29465967416763306, 0.26845821738243103, 0.10721314698457718, -0.21795226633548737, -0.20685774087905884, 0.30994582176208496, 0.03376896679401398, 0.15195348858833313, 0.09512022137641907, -0.6958498954772949, 0.2553081512451172, 0.4591502845287323, -0.36288827657699585, 0.19737140834331512, 0.22415393590927124, -0.2986290454864502, -0.6623461246490479, 0.018138639628887177, 0.2597372233867645, 0.1956712007522583, -0.3439059853553772, 0.006977091543376446, -0.6208093762397766, -0.3806301951408386, 0.5059330463409424, -0.8657137751579285, 0.3646329343318939, 0.020693527534604073, -1.058788776397705, 0.0991227850317955, 0.1871180236339569, -0.03816654533147812, -0.22828362882137299, -0.2652236521244049, -0.28505274653434753, 0.27216923236846924, -0.4841736853122711, 0.11090897023677826, -0.2556367516517639, 0.2856462299823761, -0.0575072355568409, -0.43042096495628357, 0.17754842340946198, 0.7888302803039551, 0.5169965028762817, -0.7882616519927979, -0.5544456243515015, 0.08825251460075378, 0.7489805221557617, -0.1588476449251175, -0.12352228909730911, 0.24333786964416504, 0.5085366368293762, -0.17032714188098907, -0.0970962643623352, -0.3696572482585907, -0.31426018476486206, 0.06442393362522125, -0.5561450719833374, -0.41845986247062683, -0.41406458616256714, -0.3687116205692291, -0.2045426219701767, 0.15658338367938995, 0.09499293565750122, -0.8648242354393005, 0.37993910908699036, -0.6393089294433594, 0.3866980969905853, 0.18152569234371185, 0.9474534392356873, 0.5328562259674072, 0.1066587045788765, 0.2235369235277176, -0.05880558490753174, 0.3450421392917633, -0.28380048274993896, -0.010304165072739124, 0.06419359147548676, -0.3773113489151001, 0.32803380489349365, -0.2647339105606079, 0.6084104776382446, -0.7008230090141296, 0.3250054121017456, -0.5842427015304565, -0.025003401562571526, 0.0846882164478302, -0.12461961805820465, 0.36716726422309875, -0.6311168670654297, -0.3604218363761902, -0.3718644976615906, 0.12790872156620026, 0.10564602166414261, 0.014385501854121685, 0.04433925077319145, -0.000324556662235409, -0.4571970999240875, 0.5018424391746521, 0.7901803255081177, -0.5529215931892395, -0.3575705587863922, 0.441123366355896, 0.26301857829093933, -0.6303147077560425, -0.39503753185272217, -0.07232458144426346, -0.12832145392894745, -0.12700676918029785, 0.27351853251457214, 0.15519194304943085, -0.2738999128341675, 0.2519325315952301, 0.10106991976499557, -0.3687489628791809, 0.44935259222984314, 0.46720078587532043, 0.1755325198173523, 0.6872068047523499, 0.47647079825401306, -0.4318711459636688, -0.4331742823123932, 0.005807482637465, 0.06105630472302437, 0.2041221559047699, 0.022971685975790024, 0.603298008441925, 1.0239806175231934, 0.5520408749580383, 0.3653455078601837, 0.45297321677207947, 0.2981117069721222, -0.11487416177988052, -0.053003109991550446, -0.30975133180618286, -0.32496529817581177, -0.008682865649461746, 0.43614596128463745, 0.47401106357574463, 0.20456118881702423, -0.18482346832752228, -0.20571820437908173, 0.7466862797737122, 0.395506888628006, 0.5429431796073914, -0.601253867149353, 0.2566739618778229, 0.37772855162620544, -0.17738129198551178, -0.3908941447734833, 0.07748951762914658, -0.4835338592529297, -0.08950747549533844, 0.23654167354106903, -0.23841939866542816, 0.06739049404859543, 0.45401597023010254, -0.24408067762851715, 0.3006848096847534, 0.2038542777299881, 0.5002694725990295, -0.26664307713508606, 0.20263056457042694, 0.5434690713882446, 0.13653577864170074, 0.25965946912765503, -0.39591994881629944, -0.13730508089065552, 0.2191053032875061, -0.31488221883773804, 0.6396389603614807, -0.16168144345283508, -0.5840849876403809, 0.2548663914203644, -0.37249520421028137, 0.08020035922527313, 0.38474220037460327, -0.051947738975286484, 0.04772774875164032, -0.14989663660526276, -0.5895867347717285, 0.13449828326702118, -0.3890573978424072, -0.5282816886901855, 0.11459994316101074, -0.2730712890625, 0.0016791635425761342, -0.26828843355178833, -0.32784217596054077, 0.7177732586860657, -0.07038519531488419, 0.3127932548522949, 0.3073190748691559, -0.2640203535556793, 0.143183633685112, 0.14938169717788696, 0.4594745635986328, -0.25958573818206787, 0.6755853295326233, -0.08181101828813553, 0.019597768783569336, -0.6299017071723938, 0.7829146385192871, -0.714993953704834, -0.204629048705101, -0.49640190601348877, -0.012507718056440353, 0.5672452449798584, 0.5087602138519287, -0.34806886315345764, 0.11089926213026047, -0.12102922052145004, 0.46399205923080444, 0.3478124141693115, -0.5392723083496094, -0.1493479460477829, -0.295820951461792, -0.587145209312439, -0.44893476366996765, 0.44214242696762085, 0.07356127351522446, -0.3416390120983124, 0.07069678604602814, 0.6266588568687439, 0.05279553309082985, -0.5358371138572693, 0.1316090077161789, -0.40987738966941833, -0.3474666178226471, -0.5422948598861694, 0.7438156604766846, -0.7100796699523926, 0.3851541578769684, -0.6080420017242432, 0.20624953508377075, 0.0015288317808881402, -0.35561996698379517, 0.3256509304046631, 0.053740665316581726, 0.3734772503376007, -0.15241651237010956, 0.2369762361049652, 0.257784366607666, -0.5518004298210144, -0.798254132270813, -0.6534139513969421, 0.2575126886367798, 0.10532393306493759, -0.7333748936653137, -0.03438590466976166, -0.16865324974060059, -0.007853299379348755, -0.02311246655881405, -0.006155451759696007, -0.16841372847557068, -0.24600093066692352, -0.06580629199743271 ]
Adipose tissue hypoxia and inflammation have been causally implicated in obesity-induced insulin resistance. Here, we report that, early in the course of high-fat diet (HFD) feeding and obesity, adipocyte respiration becomes uncoupled, leading to increased oxygen consumption and a state of relative adipocyte hypoxia. These events are sufficient to trigger HIF-1α induction, setting off the chronic adipose tissue inflammatory response characteristic of obesity. At the molecular level, these events involve saturated fatty acid stimulation of the adenine nucleotide translocase 2 (ANT2), an inner mitochondrial membrane protein, which leads to the uncoupled respiratory state. Genetic or pharmacologic inhibition of either ANT2 or HIF-1α can prevent or reverse these pathophysiologic events, restoring a state of insulin sensitivity and glucose tolerance. These results reveal the sequential series of events in obesity-induced inflammation and insulin resistance.
[ -0.033548228442668915, 0.017273303121328354, -0.012148262932896614, 0.03988926485180855, 0.004499516449868679, -0.02587682008743286, 0.010821993462741375, 0.018268294632434845, -0.014100511558353901, -0.010249275714159012, -0.005872002337127924, 0.005850233603268862, -0.028812024742364883, 0.020601220428943634, -0.009926185011863708, 0.010014763101935387, -0.0007004092913120985, 0.012038735672831535, 0.0006382273277267814, 0.00550138670951128, 0.033586978912353516, -0.024795815348625183, 0.01061409991234541, -0.010576448403298855, -0.01305711455643177, -0.005206448491662741, 0.03777235001325607, -0.03883633762598038, -0.017818273976445198, -0.004906587302684784, -0.01255623996257782, -0.011727439239621162, 0.002745098201557994, 0.05021759122610092, 0.00270251976326108, 0.018537670373916626, -0.0026430487632751465, 0.02096136286854744, 0.011806518770754337, -0.004570720251649618, -0.009099211543798447, -0.01166473887860775, 0.001199765014462173, -0.012917635962367058, -0.006022610701620579, -0.0009168973192572594, 0.003596801543608308, 0.00015739724040031433, -0.013227620162069798, 0.00475415401160717, -0.010592805221676826, -0.04180936515331268, -0.011856325902044773, 0.0507323294878006, -0.006124216131865978, 0.0073273638263344765, 0.019196439534425735, -0.002441561780869961, -0.058601152151823044, 0.02315661497414112, -0.016110170632600784, -0.003054040716961026, -0.003680919762700796, 0.017316458746790886, 0.023214293643832207, -0.06650584191083908, 0.0150567926466465, -0.022718995809555054, 0.007082758937031031, -0.004141703713685274, -0.019913744181394577, 0.0006803054711781442, 0.006359510589390993, 0.028226790949702263, -0.005637789145112038, 0.021618947386741638, 0.022495046257972717, -0.00972689874470234, 0.04667239636182785, 0.014012669213116169, 0.006159593351185322, -0.015400166623294353, -0.002498459303751588, 0.024102188646793365, -0.007642283570021391, -0.0018064199248328805, -0.02520141750574112, -0.0061287772841751575, 0.0005329372361302376, 0.010617639869451523, -0.0010451464913785458, -0.016551893204450607, 0.005110721569508314, -0.004157619550824165, -0.01782940700650215, 0.007036224007606506, -0.009269548580050468, 0.0228622667491436, 0.027197888121008873, 0.004512172657996416, -0.010498521849513054, -0.016538022086024284, 0.020580094307661057, -0.02263101562857628, 0.007399819791316986, 0.006922928616404533, -0.003463991219177842, 0.02014900930225849, 0.023858513683080673, 0.01478838361799717, -0.012883147224783897, 0.02138129435479641, 0.01237828191369772, 0.01758001744747162, 0.008244583383202553, 0.03426496312022209, -0.01880491152405739, 0.0059907082468271255, 0.011586359702050686, -0.008555220440030098, 0.009272429160773754, -0.019946904852986336, 0.005573469214141369, 0.018638934940099716, -0.0033199251629412174, -0.00506901228800416, 0.005317994859069586, 0.006022104062139988, -0.038861773908138275, -0.020612427964806557, -0.006417020224034786, -0.006109277717769146, -0.0021646961104124784, 0.011008858680725098, -0.007084345910698175, 0.0035115841310471296, -0.04727984219789505, -0.0048966738395392895, -0.026088204234838486, -0.004291245713829994, 0.002279846929013729, 0.0019783000461757183, -0.004823924042284489, 0.00676526827737689, -0.016659358516335487, 0.006967237219214439, 0.007473884150385857, -0.014574883505702019, 0.04927428811788559, -0.029950741678476334, 0.0025702370330691338, 0.012502435594797134, -0.0023249660152941942, -0.013522366061806679, 0.008920390158891678, 0.010202166624367237, -0.025507953017950058, 0.01819213666021824, -0.0005805674009025097, 0.0008164523169398308, -0.0036814401391893625, -0.02556987851858139, 0.012659335508942604, 0.010179536417126656, 0.000052061863243579865, 0.002703288570046425, 0.012998074293136597, -0.012613551691174507, -0.0005666837096214294, 0.007904436439275742, -0.016001317650079727, 0.0035141357220709324, -0.025439240038394928, 0.008778941817581654, -0.006827891804277897, -0.023966427892446518, -0.01958453841507435, 0.007313852664083242, 0.002861235523596406, 0.06608695536851883, 0.02883101999759674, -0.021666601300239563, -0.018101844936609268, 0.01946398988366127, 0.013888430781662464, -0.011160729452967644, 0.012662984430789948, -0.015114114619791508, 0.005816040560603142, -0.022709358483552933, -0.013292602263391018, 0.016237810254096985, 0.04795233905315399, -0.013235853984951973, 0.00098048010841012, 0.002480188151821494, 0.020951425656676292, 0.008622460067272186, 0.0027866452001035213, 0.0025313878431916237, 0.017279520630836487, -0.022082973271608353, 0.03514617681503296, 0.0020142290741205215, -0.006302061956375837, 0.0015762923285365105, 0.0034258845262229443, -0.030246177688241005, 0.007110749837011099, -0.0000028833746910095215, 0.0137324258685112, 0.008728515356779099, 0.003691022051498294, -0.003323298878967762, 0.008160976693034172, 0.01106330193579197, 0.005317129194736481, 0.0063487873412668705, -0.016376089304685593, -0.01269227359443903, 0.014503168873488903, 0.0068848636001348495, -0.012489364482462406, -0.03228123486042023, -0.010988686233758926, -0.003260958008468151, -0.007876145653426647, 0.011697565205395222, 0.000670762499794364, 0.015655022114515305, 0.00701298750936985, -0.004235450644046068, -0.011549359187483788, -0.026050984859466553, 0.020999876782298088, -0.017442435026168823, 0.015171930193901062, -0.002238620538264513, 0.014955718070268631, -0.015697676688432693, -0.004069606773555279, -0.002720534335821867, 0.040404416620731354, -0.008486692793667316, -0.0036845526192337275, 0.018605681136250496, 0.013507549650967121, 0.007522837724536657, 0.010771923698484898, -0.010973213240504265, 0.009219571948051453, -0.0063385432586073875, -0.02392515540122986, -0.010638737119734287, -0.0358082540333271, -0.06343397498130798, 0.006862554233521223, -0.028232984244823456, 0.025951355695724487, -0.019017726182937622, 0.011845521628856659, 0.00452396459877491, 0.010352259501814842, -0.0006238946225494146, -0.034535475075244904, 0.0318993479013443, -0.006619627587497234, -0.008702950552105904, -0.007516333367675543, 0.014253336004912853, 0.00538887782022357, -0.007842455059289932, -0.022471625357866287, -0.08111771941184998, -0.019261697307229042, -0.006719276309013367, 0.03527388349175453, 0.00922064296901226, -0.01003627572208643, 0.02412295900285244, 0.007874145172536373, -0.022558409720659256, 0.003576146438717842, -0.010408968664705753, -0.003875077934935689, -0.0031360092107206583, 0.013080988079309464, -0.0510181188583374, -0.011610742658376694, 0.0060212984681129456, 0.0031202086247503757, 0.0003352537751197815, -0.0060307951644063, 0.012951144948601723, -0.01729983277618885, 0.011099651455879211, -0.006628518924117088, 0.01948082447052002, -0.020554376766085625, 0.018358886241912842, -0.037363436073064804, -0.008418615907430649, 0.01269217673689127, 0.02752525359392166, 0.006812598556280136, -0.001185725792311132, -0.02496313489973545, -0.018407098948955536, 0.009082564152777195, -0.02937627211213112, -0.01416923850774765, -0.023749135434627533, -0.030025705695152283, -0.008670611307024956, -0.0006890203803777695, 0.017054731026291847, -0.00038465019315481186, 0.019955139607191086, 0.008961341343820095, -0.030383208766579628, -0.01613878831267357, 0.02092158794403076, 0.021330446004867554, -0.01324155181646347, 0.003064270131289959, -0.00017861905507743359, 0.01649688556790352, -0.014256807044148445, -0.014891846105456352, -0.014099390245974064, -0.008531980216503143, -0.009835628792643547, -0.014200852252542973, 0.0135349715128541, -0.02432483434677124, 0.025255559012293816, -0.01262457761913538, -0.04839791730046272, -0.0027914701495319605, 0.0221048966050148, -0.0003426021430641413, -0.008831022307276726, 0.013073582202196121, -0.0026348039973527193, -0.0076958718709647655, 0.003803134895861149, -0.010497724637389183, -0.007398207206279039, -0.00425388989970088, -0.011674468405544758, -0.013419589959084988, 0.02660565823316574, -0.0009434130042791367, -0.03755960613489151, -0.017590047791600227, -0.005575825460255146, 0.011677094735205173, -0.0016382273752242327, 0.022210322320461273, 0.007826447486877441, 0.027997516095638275, 0.031531091779470444, -0.01702280528843403, -0.002660666825249791, 0.011173608712852001, 0.011666681617498398, 0.014172662049531937, 0.023331116884946823, 0.01605025678873062, -0.008128853514790535, -0.03697630763053894, 0.004268556367605925, 0.009118663147091866, -0.0372738242149353, -0.006327573210000992, -0.006267487537115812, -0.004185312893241644, 0.005392048507928848, 0.019993791356682777, 0.01274162344634533, -0.0062188319861888885, -0.040154118090867996, -0.0018593801651149988, -0.01167280413210392, -0.0400119349360466, -0.002159044612199068, -0.0037453295662999153, 0.0195697583258152, -0.010159173980355263, 0.003623806871473789, 0.007029372733086348, 0.07141277194023132, -0.007521010935306549, -0.0008742460631765425, -0.00023392844013869762, 0.0341254398226738, -0.024442387744784355, -0.027878906577825546, 0.020544691011309624, 0.03901280462741852, -0.01509783323854208, 0.01392744667828083, -0.009391137398779392, -0.03199943155050278, 0.047594618052244186, 0.016013983637094498, 0.02792624942958355, -0.02282636985182762, -0.01934014819562435, 0.0007052239961922169, -0.015198989771306515, -0.014703582972288132, 0.03862728923559189, 0.011946666985750198, -0.0071536581963300705, 0.01699250191450119, -0.07696355134248734, -0.02750975824892521, -0.014084815979003906, -0.01974775642156601, 0.006195040885359049, -0.004604017827659845, 0.001679867971688509, -0.0044533368200063705, -0.011707408353686333, -0.0347055122256279, 0.00567846791818738, -0.004972930531948805, -0.020349062979221344, 0.0018172012642025948, -0.016086941584944725, -0.018786385655403137, -0.01728523150086403, -0.0015975360292941332, 0.013687727972865105, -0.007234945427626371, 0.007866716012358665, 0.029615052044391632, -0.0055489069782197475, -0.01792120933532715, 0.02005644515156746, 0.000030212104320526123, -0.0034055619034916162, 0.004102650098502636, 0.02022378146648407, 0.01766798458993435, 0.012292366474866867, -0.0064068324863910675, -0.005151714663952589, -0.00727322930470109, -0.018859881907701492, -0.010975074023008347, -0.02052246406674385, 0.016267254948616028, 0.0019513648003339767, 0.012014283798635006, -0.0019918468315154314, -0.010745042935013771, 0.013078313320875168, 0.010594415478408337, 0.011888217180967331, 0.03537290543317795, 0.014758812263607979, -0.005253114737570286, -0.029171211645007133, -0.021608911454677582, 0.010333006270229816, 0.00954417884349823, -0.01095082052052021, 0.019103877246379852, -0.017319753766059875, -0.03263652324676514, 0.021510854363441467, -0.008554064668715, -0.013590643182396889, 0.020030179992318153, -0.012561250478029251, 0.005098716355860233, -0.07476004958152771, -0.014199303463101387, -0.011539648286998272, -0.014401597902178764, 0.019789285957813263, 0.024592941626906395, -0.008172500878572464, 0.005747995339334011, -0.0500955656170845, 0.006622329354286194, -0.01943378895521164, -0.02195105515420437, -0.0023365409579128027, 0.015269424766302109, 0.01065750140696764, 0.03693452477455139, -0.016351919621229172, 0.00961984135210514, -0.013429076410830021, 0.0025873850099742413, 0.005191088188439608, -0.0050077373161911964, -0.004919141530990601, -0.0006368756294250488, -0.0029847074765712023, -0.08037914335727692, -0.02649901993572712, -0.0021216198801994324, -0.030715860426425934, 0.017707794904708862, -0.03562682867050171, 0.03629050403833389, -0.011319750919938087, 0.03554699569940567, -0.021012816578149796, 0.0017464100383222103, -0.002938114106655121, 0.008073059841990471, -0.019764089956879616, 0.019784919917583466, -0.020480336621403694, 0.011012362316250801, 0.037959400564432144, 0.003427804447710514, 0.018150560557842255, -0.0018166960217058659, 0.016385193914175034, -0.010085719637572765, 0.008696772158145905, -0.006393315736204386, -0.003356805071234703, -0.01405576802790165, 0.008372092619538307, 0.024523884057998657, -0.02293885126709938, -0.01720789261162281, -0.012258020229637623, -0.020593484863638878, 0.03391379863023758, 0.0039497846737504005, -0.023961391299962997, 0.01943669468164444, -0.014995759353041649, 0.014691602438688278, -0.002658091252669692, 0.0003224453830625862, -0.031763508915901184, -0.002736284863203764, -0.01589304208755493, -0.016673054546117783, -0.009062321856617928, 0.00588991167023778, -0.011849207803606987, 0.009853754192590714, 0.003611341118812561, 0.0007231553317978978, -0.0031287679448723793, 0.02487298659980297, -0.01539374515414238, -0.017315344884991646, -0.006505548022687435, -0.008842585608363152, 0.02238438092172146, 0.0073402696289122105, 0.00007060368079692125, -0.011895207688212395, 0.008400275371968746, 0.019641585648059845, 0.07108907401561737, 0.010915395803749561, -0.006998927798122168, 0.00018853205256164074, -0.007674098014831543, 0.007147704716771841, -0.019137423485517502, -0.035758666694164276, -0.02146890014410019, 0.004570719785988331, -0.030760712921619415, -0.03004743531346321, -0.0019370957743376493, 0.010278919711709023, 0.03557934984564781, -0.005985318683087826, 0.04066411405801773, -0.028547078371047974, -0.029252594336867332, 0.03071681782603264, -0.0040756529197096825, 0.0066535575315356255, -0.029235761612653732, 0.024545595049858093, 0.029310688376426697, -0.01305747963488102, -0.0106537826359272, -0.0017610625363886356, -0.004315010271966457, 0.026386357843875885, -0.018851615488529205, -0.029118508100509644, 0.0011330696288496256, -0.02713029831647873, 0.02435366064310074, -0.013888005167245865, 0.006029762793332338, 0.010683808475732803, -0.04592113196849823, 0.018644900992512703, 0.030582983046770096, 0.01687687449157238, -0.004331704694777727, 0.0007005073130130768, 0.02602902427315712, 0.00810410175472498, 0.02094009518623352, -0.023036636412143707, -0.024387376382946968, 0.018437689170241356, -0.03189681097865105, -0.014804386533796787, 0.0009034983813762665, -0.0034399298019707203, 0.02003379724919796, -0.010690396651625633, -0.017386002466082573, 0.009901199489831924, -0.020096929743885994, -0.009457910433411598, -0.01034584641456604, -0.02430996112525463, 0.02613356150686741, -0.030997827649116516, 0.03710537031292915, -0.007087578531354666, 0.0025281107518821955, -0.021807730197906494, -0.013689695857465267, 0.014767375774681568, 0.008833929896354675, 0.0016388753429055214, 0.00703785102814436, -0.018472494557499886, 0.04628710448741913, -0.005237456411123276, 0.021123800426721573, 0.006985359825193882, -0.0016654514474794269, 0.0034760041162371635, -0.005857349373400211, 0.010080439038574696, -0.006989132147282362, -0.0013203504495322704, -0.02053484506905079, -0.031033145263791084, 0.01940864324569702, -0.04643182456493378, -0.009632939472794533, 0.009785262867808342, -0.08229527622461319, -0.00013726786710321903, 0.0029973802156746387, -0.011084282770752907, 0.008087876252830029, 0.03502301126718521, 0.03365078940987587, 0.000964086502790451, -0.022808603942394257, -0.011249907314777374, -0.023493457585573196, 0.011492668651044369, 0.01518192794173956, -0.0010359506122767925, -0.0050008539110422134, -0.007279225625097752, 0.03808961808681488, -0.04278534650802612, 0.015345022082328796, -0.02707761339843273, 0.021510064601898193, -0.017497969791293144, 0.02701612189412117, 0.01927505061030388, 0.02711685746908188, 0.02446310967206955, -0.0016748994821682572, -0.01601412147283554, 0.011744320392608643, -0.014714998193085194, -0.0005168637726455927, -0.00450345641002059, 0.017824482172727585, -0.006132260896265507, 0.013706071302294731, 0.011095801368355751, -0.0036117308773100376, 0.01976616308093071, 0.021790072321891785, 0.015295898541808128, 0.019599484279751778, -0.029569337144494057, -0.006457189098000526, -0.010248560458421707, -0.00031639495864510536, 0.00816991738975048, 0.007611262612044811, 0.037429675459861755, -0.012577643617987633, 0.028806865215301514, -0.01708161272108555, 0.001665750751271844, -0.0016983116511255503, 0.0139604602009058, 0.006741189863532782, 0.00958784855902195, 0.00908900611102581, -0.02532719261944294, 0.016243454068899155, -0.021591268479824066, 0.0080804992467165, 0.009943503886461258, -0.00018731411546468735, -0.002186083234846592, 0.007426705211400986, 0.004220991861075163, 0.0010965755209326744, -0.0021378742530941963, -0.017988253384828568, -0.041340019553899765, 0.013375408947467804, -0.03762078657746315, 0.0018162415362894535, 0.014866277575492859, 0.019304394721984863, 0.028410915285348892, -0.015485423617064953, 0.02117849327623844, -0.008586311712861061, -0.0001439182087779045, 0.019191108644008636, 0.007312727626413107, -0.009782669134438038, 0.00211679027415812, -0.04016768932342529, -0.008485337719321251, -0.023906808346509933, -0.0006128607783466578, 0.007851241156458855, -0.008222896605730057, 0.005459143314510584, -0.024537406861782074, -0.0014281377661973238, -0.009168252348899841, 0.003441024571657181, -0.00005673547275364399, -0.009902259334921837, 0.00546175567433238, 0.00998255331069231, 0.0004720189608633518, -0.010093601420521736, -0.010066190734505653, 0.006516268011182547, 0.0026032470632344484, 0.006525217089802027, -0.027096230536699295, -0.008118817582726479, -0.041056983172893524, -0.007733806502074003, -0.010155733674764633, -0.006494161207228899, -0.006946680601686239 ]
[ -0.22853747010231018, 0.08162672072649002, 0.1884206384420395, -0.1516546756029129, 0.08514490723609924, 0.1801028549671173, 0.3560935854911804, -0.41732317209243774, -0.06273278594017029, -0.5913700461387634, 0.20147916674613953, 0.352347195148468, -0.6563989520072937, 0.030791155993938446, -0.13455700874328613, 0.5048915147781372, 0.6163801550865173, 0.4398420453071594, -0.19818854331970215, -0.4977186918258667, -0.22210481762886047, -0.2588497996330261, 0.6842044591903687, 0.48406100273132324, 0.0534578412771225, -0.30916598439216614, 0.4895378649234772, 0.1418350487947464, 0.3180263340473175, -0.3619665503501892, -0.5946698188781738, 0.6729515194892883, 0.34082067012786865, -0.1134083941578865, -0.18072126805782318, 0.2500925660133362, -0.16097374260425568, -0.2822100520133972, 0.16871662437915802, 0.05877681076526642, -0.4992256760597229, 0.14316819608211517, -0.056314799934625626, 0.526703417301178, -0.04992468282580376, -0.17234088480472565, -1.6227468252182007, 0.5883187651634216, -0.17067648470401764, 0.15185603499412537, 0.17016074061393738, 0.4014488160610199, 0.49403634667396545, 0.0037406443152576685, 0.4242728352546692, 0.29993194341659546, -0.8391175866127014, -0.10076931864023209, 0.37963902950286865, -0.5294950008392334, 0.21714112162590027, -0.13181164860725403, -0.31099817156791687, -0.2638845145702362, -0.3537280261516571, 0.5516852736473083, -0.013478672131896019, -0.12065845727920532, -0.3392879366874695, 0.2878696322441101, 0.07538263499736786, -0.5488771200180054, -0.3950812518596649, 0.33615800738334656, -0.15007701516151428, 0.08460099995136261, -0.3048730790615082, -0.1258217841386795, 0.11126117408275604, 0.1148623451590538, 0.0036892921198159456, 0.1054764837026596, 0.5332044363021851, 0.16107352077960968, 0.1327952742576599, -0.06082469969987869, 0.10352995246648788, 0.982964277267456, -0.2188355177640915, -0.20949840545654297, -0.05100187659263611, 0.09777554869651794, 0.3545399308204651, 0.13782396912574768, -0.03979860618710518, 0.06099621206521988, 0.1557820439338684, -0.10931331664323807, 0.2658866047859192, 0.2690816819667816, 0.017152180895209312, -0.3608717620372772, -0.15255267918109894, -0.1911708563566208, 0.06373198330402374, -0.4710679054260254, -0.28287774324417114, -0.29989585280418396, -0.2825409471988678, -0.09246793389320374, -0.9465646147727966, 0.3828596770763397, -0.600018322467804, -0.7599438428878784, 0.13705214858055115, 0.027763376012444496, -0.14514479041099548, -0.6546911001205444, -0.4758499562740326, -0.40121620893478394, -0.10863341391086578, 0.8922627568244934, -0.18736456334590912, 0.3315587639808655, -0.3159925043582916, -0.3278900384902954, 0.16406133770942688, -0.24209336936473846, 0.17270399630069733, 0.6016610860824585, 0.23901648819446564, 0.4505472481250763, -0.2524816393852234, -0.2434091567993164, 0.13773474097251892, -0.03512369468808174, 0.11080097407102585, 0.2828005254268646, 0.5873258709907532, -0.08772606402635574, -0.3022151291370392, -0.3781602084636688, -0.36339321732521057, -0.09676944464445114, -0.11451829969882965, -0.17739778757095337, -0.343060702085495, -0.028745552524924278, 0.07231680303812027, -0.2966361343860626, 0.5557119846343994, -0.38529083132743835, -0.7189562916755676, 0.14008763432502747, 0.1337713897228241, 0.5750564932823181, 0.04259337857365608, -0.8636874556541443, 0.20742404460906982, 0.3573065400123596, 0.4423084259033203, -0.4440678656101227, -0.3933979570865631, -0.2528422176837921, 0.5043447017669678, 0.05804229527711868, 0.1756599396467209, 0.2833956778049469, 0.32565462589263916, 0.1366323083639145, -0.3965812921524048, -0.494158536195755, -0.16957475244998932, -0.4722900390625, 0.08109737932682037, -0.029546594247221947, 0.3402647376060486, -0.034711871296167374, 0.11298753321170807, 0.118301160633564, -0.9016671776771545, 0.030245916917920113, -0.1648724526166916, -0.5776090025901794, 0.6700952053070068, 0.2939901649951935, 0.6437999606132507, 0.2665244936943054, 0.5391299724578857, -0.011839797720313072, -0.1033678725361824, -0.6286925077438354, 1.005961537361145, -0.42976731061935425, 1.5782259702682495, -0.32869189977645874, -0.36205190420150757, 0.8379508256912231, 0.2507321536540985, -0.33535245060920715, 0.1795605570077896, 0.15337377786636353, 0.57148277759552, -0.4148121178150177, -0.40437257289886475, -0.039513006806373596, -0.31905412673950195, -0.3119814693927765, 0.168267622590065, 0.3519255518913269, 0.3547721207141876, -0.4369906783103943, -0.1816239356994629, -0.4157445728778839, 0.5872324705123901, -0.3679508566856384, 0.0367586575448513, 0.05277078598737717, -0.6359145641326904, -0.2784767150878906, 0.33088651299476624, -0.3602421283721924, 0.4961080253124237, 0.5914791226387024, 0.29408299922943115, 0.6485396027565002, 0.5117645263671875, 0.3177689015865326, 0.9480406045913696, -0.21391227841377258, 0.10752494633197784, -0.31284406781196594, 0.21994923055171967, -0.33075782656669617, 0.29900529980659485, 0.22039803862571716, 0.2857295572757721, -0.1826702356338501, 0.04524782672524452, -0.04504496976733208, -0.09821674972772598, 0.8342826962471008, -0.8847278952598572, -0.20303787291049957, 0.09587880969047546, -0.5391180515289307, -0.4747440218925476, 0.45492660999298096, -1.217955470085144, -0.43740013241767883, 0.21371851861476898, 0.290073961019516, 0.2208709567785263, -0.6136714816093445, -0.041286125779151917, -0.07946467399597168, -0.003605110803619027, -0.17955729365348816, 0.400253027677536, -0.6798548698425293, -0.35455089807510376, 0.045503295958042145, 0.2593213617801666, 0.34235838055610657, 0.12347397953271866, 0.23394183814525604, -0.7391676902770996, -0.6735200881958008, 0.8194347620010376, 0.7038244605064392, 1.1102900505065918, -0.08929304778575897, -0.6993488669395447, -0.0965581163764, 0.00713576003909111, -0.6357067227363586, -0.020337536931037903, 1.060884714126587, -0.5718197226524353, -0.30118903517723083, 0.07189816236495972, 0.5845193266868591, 0.8043761849403381, -0.23008587956428528, -0.6267773509025574, 0.19907677173614502, -0.16982494294643402, -0.13419987261295319, -0.5906970500946045, -0.5244426131248474, -0.22707980871200562, 0.47901973128318787, -0.4498898983001709, -0.07456134259700775, 0.5401601195335388, 0.15542703866958618, -0.11646484583616257, 0.868503212928772, 0.5908188223838806, -0.24685513973236084, 0.22573436796665192, -0.08368275314569473, -0.33392518758773804, -0.016463981941342354, -0.42046114802360535, 0.05659257248044014, -0.262401819229126, 0.08214835822582245, -5.730346202850342, -0.21818605065345764, 0.16523794829845428, -0.11902222037315369, 0.053656481206417084, -0.04645746201276779, 0.9645088315010071, 0.25265395641326904, 0.43363404273986816, 0.549725353717804, 0.27179858088493347, 0.20580843091011047, 0.001864388701505959, -0.45540910959243774, -0.746303379535675, 0.04439929872751236, 0.03559836372733116, -0.32049956917762756, 0.5676712989807129, 0.18875426054000854, 0.5596884489059448, -0.17878617346286774, -0.14866837859153748, 0.7438727617263794, 0.11383212357759476, -0.015155543573200703, -0.690199077129364, 0.2958049178123474, -0.248771071434021, -0.4563380181789398, -0.062349818646907806, -0.6391404867172241, 0.2401912808418274, -0.01681184396147728, 0.4820750653743744, 0.13541710376739502, -0.1312972456216812, -0.031052706763148308, -0.12198720872402191, -0.4296417236328125, -0.02431638352572918, -0.1499994546175003, -0.507064938545227, 0.15992318093776703, 0.22052539885044098, 0.020270856097340584, 0.029995080083608627, -0.08570069074630737, -0.29656267166137695, 0.5055469870567322, 0.23282821476459503, -0.4640505611896515, 0.32652196288108826, 0.7370857000350952, 0.7303183078765869, 0.36968812346458435, -0.3787008821964264, 0.00463628675788641, 0.06202052906155586, 0.09226606041193008, -0.2791157066822052, -0.3651393949985504, -0.5801723599433899, -0.48744991421699524, 0.11889994889497757, 0.6153795123100281, -0.33710405230522156, -0.233724445104599, 0.4701892137527466, -0.2026480883359909, -0.1920337677001953, -0.0007725576288066804, 0.32851162552833557, -0.7106401324272156, 0.7483762502670288, -0.360168993473053, 0.23285961151123047, 0.22489388287067413, -0.12374868988990784, -0.4469601511955261, -0.5073836445808411, 0.1273304522037506, -0.06979428231716156, -0.12494973093271255, 0.7908250093460083, -0.29961714148521423, -0.5511631369590759, -0.33198943734169006, -0.07640141993761063, 0.5189794301986694, 0.3896251618862152, -0.2680639326572418, -0.1307821124792099, 0.6753919124603271, 0.08128167688846588, 0.4897453784942627, 0.20316152274608612, 0.5505134463310242, 0.5948585271835327, 0.07221788913011551, 0.5274444222450256, 0.12028355896472931, -0.27822819352149963, -0.40655025839805603, 0.0659225583076477, 0.284119576215744, -0.5174025893211365, 0.033030055463314056, 0.7386281490325928, -1.0204225778579712, 0.03443056717514992, -0.0015782994451001287, -0.8184717297554016, -0.6368617415428162, 0.4645881652832031, -0.2948693037033081, -0.23005488514900208, 0.19939930737018585, 0.906690239906311, -0.17664355039596558, -0.024170441552996635, 0.328823447227478, -0.6277157068252563, 0.07692008465528488, 0.3908943235874176, 0.19659802317619324, -0.010898873209953308, 0.924622118473053, -0.5575018525123596, -0.11740729212760925, 0.2896747589111328, 0.1924862414598465, -0.11747006326913834, 0.25421255826950073, 0.163161501288414, -0.4179038107395172, -0.10309051722288132, 0.0054146600887179375, 0.3690144717693329, -0.31399005651474, 0.1078585758805275, -0.2962295114994049, -0.4438544511795044, -0.3885394036769867, 0.5594049692153931, 0.2355317771434784, -0.014859057031571865, -0.26982033252716064, -0.4889737367630005, -0.06674100458621979, 0.4560357332229614, 0.14336369931697845, -0.006576169282197952, 0.1055188700556755, -0.888312816619873, 0.29690656065940857, 0.499254047870636, -0.06546379625797272, 0.29537445306777954, -0.4479617476463318, 0.3479931056499481, -0.33513426780700684, -0.7962596416473389, -0.002595225116237998, -0.5252536535263062, -0.10744462162256241, -0.19665095210075378, -0.7068120837211609, -0.016170846298336983, 0.013644642196595669, -0.28054824471473694, -0.19497284293174744, -0.029388336464762688, 0.12657397985458374, 0.12641356885433197, -0.7486749887466431, -0.30614370107650757, 0.2429131269454956, 0.04865163564682007, 0.06380204856395721, 0.10404712706804276, -0.6345522999763489, -0.3913680613040924, 0.15306346118450165, 0.4619847238063812, -0.13525839149951935, 0.05348359793424606, -0.07642518728971481, -0.5508686304092407, -0.5406165719032288, -0.016235200688242912, -0.12307260930538177, 0.5895376801490784, -0.4911389648914337, 0.41658273339271545, 0.15712685883045197, 0.279001921415329, 0.014108809642493725, -0.052863944321870804, -0.16457442939281464, 0.1753242313861847, 0.11282268166542053, -0.3596561551094055, 0.15886373817920685, 0.5293452143669128, 0.27041372656822205, -0.6347641348838806, 0.10731028020381927, -0.08367803692817688, -0.12525634467601776, -0.058182425796985626, -0.6935608386993408, 0.2112414538860321, 0.4860544204711914, -0.11635827273130417, -0.06243479251861572, 0.2940135896205902, -0.3125936985015869, -0.0579451359808445, 0.14663900434970856, 0.712874710559845, 0.18878105282783508, -0.0298604816198349, -0.21862876415252686, -0.41312408447265625, 0.07922626286745071, 0.6175224781036377, -0.8637170791625977, 0.3008232116699219, 0.04239017516374588, -0.20726123452186584, -0.14702282845973969, -0.233148455619812, -0.16262035071849823, -0.26720064878463745, -0.19561196863651276, 0.006017383188009262, 0.37472859025001526, -0.02924206107854843, 0.7419670224189758, 0.22362123429775238, 0.9163901209831238, -0.05800222232937813, -0.02944977395236492, -0.0639684647321701, 0.6570570468902588, 0.05052677541971207, -0.6925893425941467, -0.4892536997795105, 0.37787342071533203, 0.7032822966575623, -0.12806560099124908, -0.08369863778352737, 0.40438520908355713, 0.8869628310203552, -0.23592542111873627, -0.06357647478580475, -0.49999701976776123, -0.35136187076568604, 0.4804189205169678, -0.03506660461425781, -0.05952765792608261, 0.042399995028972626, 0.23732991516590118, 0.27116507291793823, 0.04776228591799736, -0.2618466317653656, -0.5464364886283875, 0.6493923664093018, -0.2456466555595398, 0.06096438318490982, 0.02020672895014286, 0.28930625319480896, 0.03355537727475166, -0.1424102783203125, 0.32788777351379395, -0.6740320920944214, -0.38044247031211853, -0.14755816757678986, 0.08195381611585617, 0.01490298192948103, -0.713844358921051, 0.09683911502361298, -0.15233643352985382, 0.6076640486717224, -0.8565616607666016, -0.07979296147823334, -0.5817392468452454, -0.25165051221847534, -0.16952934861183167, -0.5171268582344055, -0.015486923046410084, -0.49832239747047424, -0.5543913841247559, -0.015187623910605907, 0.37535616755485535, 0.10633833706378937, 0.06290677934885025, -0.1699679046869278, -0.5657391548156738, -0.49616387486457825, 0.7194892168045044, 0.4816550314426422, 0.17897586524486542, -0.25919225811958313, 0.43910467624664307, -0.2542020380496979, -0.31608688831329346, -0.3959120512008667, -0.20125755667686462, 0.371843159198761, -0.26558294892311096, 0.3356233835220337, 0.23910020291805267, -0.09189806878566742, 0.33451762795448303, -0.4077777564525604, 0.2815433442592621, 0.1058424860239029, 0.2133546769618988, 0.24416698515415192, 0.6032108664512634, 0.4493098855018616, -0.044411417096853256, 0.11160992085933685, 0.29540666937828064, 0.5243194699287415, 0.023137541487812996, 0.31020113825798035, 0.8518574833869934, 0.629947304725647, 0.16556265950202942, -0.14849136769771576, 0.6580201387405396, 0.608954131603241, 0.2053253948688507, 0.27087798714637756, -0.805273711681366, -0.6473605632781982, -0.21262603998184204, 0.9018445611000061, 0.2748014032840729, -0.32763391733169556, 0.11253141611814499, 0.1831098049879074, 0.44572776556015015, 0.10259991884231567, 0.2189698964357376, -0.05828072875738144, -0.26827263832092285, 0.1586548537015915, -0.3333621621131897, -0.68387371301651, -0.17903050780296326, -0.8311535120010376, 0.8468154072761536, 0.7456962466239929, -0.6846843361854553, -0.24373725056648254, 0.40925654768943787, -0.16073960065841675, 0.02366960607469082, -0.11249743402004242, 0.610826849937439, 0.31769752502441406, -0.335995614528656, 0.038502972573041916, -0.09647628664970398, 0.4119541347026825, -0.157280832529068, -0.25092196464538574, 0.09423249959945679, -0.25307154655456543, -0.30041393637657166, 0.55419921875, -0.053001973778009415, 0.08188636600971222, -0.1434331089258194, 0.536704957485199, 0.6315099000930786, -0.3269496560096741, 0.08908625692129135, -0.27013713121414185, -0.3554796576499939, -0.1075659692287445, -0.21525755524635315, -0.041750021278858185, -0.0316203311085701, 0.14278000593185425, -0.006768467370420694, -0.25513026118278503, -0.5619408488273621, 0.22387570142745972, 0.171814426779747, 0.3152596056461334, 0.1436455100774765, -0.12842638790607452, 0.3700923025608063, 0.37704968452453613, 0.5083239078521729, -0.038757357746362686, 0.03932449221611023, -0.3003968894481659, 0.41913554072380066, -0.4216201901435852, 0.8672584295272827, -0.17387020587921143, -0.40940672159194946, -0.6567400693893433, 0.14052346348762512, 1.121293306350708, 0.8357338309288025, -0.07405957579612732, 0.25381287932395935, 0.4683462679386139, 0.2360624372959137, -0.01887396350502968, -0.6186618804931641, -0.5201495289802551, -0.8473536372184753, -0.1801213026046753, -0.5560100674629211, 0.5049827694892883, -0.05754057317972183, -0.2832803428173065, -0.016369065269827843, 0.4508722722530365, 0.1329730749130249, -0.5226746201515198, 0.14907662570476532, -0.3737713098526001, 0.32669010758399963, -0.6611756682395935, 0.12259659171104431, -0.5423153638839722, 0.3873058259487152, -0.3041485846042633, 0.02020403929054737, 0.0041161831468343735, 0.09090371429920197, 0.3325640559196472, -0.21241267025470734, -0.04867643862962723, 0.2467368245124817, 0.22390227019786835, -0.1830388456583023, -0.2113945633172989, -0.7027117609977722, -0.6153233051300049, 0.2754104435443878, 0.14724379777908325, -0.5521467328071594, -0.2869649827480316, 0.04143805056810379, -0.19367794692516327, -0.1250198632478714, 0.13137254118919373, -0.32054126262664795, -0.44524437189102173, -0.46592530608177185 ]
The role of specific phospholipids (PLs) in lipid transport has been difficult to assess due to an inability to selectively manipulate membrane composition in vivo. Here we show that the phospholipid remodeling enzyme lysophosphatidylcholine acyltransferase 3 (Lpcat3) is a critical determinant of triglyceride (TG) secretion due to its unique ability to catalyze the incorporation of arachidonate into membranes. Mice lacking Lpcat3 in the intestine fail to thrive during weaning and exhibit enterocyte lipid accumulation and reduced plasma TGs. Mice lacking Lpcat3 in the liver show reduced plasma TGs, hepatosteatosis, and secrete lipid-poor very low-density lipoprotein (VLDL) lacking arachidonoyl PLs. Mechanistic studies indicate that Lpcat3 activity impacts membrane lipid mobility in living cells, suggesting a biophysical basis for the requirement of arachidonoyl PLs in lipidating lipoprotein particles. These data identify Lpcat3 as a key factor in lipoprotein production and illustrate how manipulation of membrane composition can be used as a regulatory mechanism to control metabolic pathways.
[ -0.004265518859028816, 0.008444877341389656, -0.010257745161652565, 0.008512390777468681, 0.018028559163212776, -0.00008044159039855003, 0.008880704641342163, -0.011898418888449669, -0.008203599601984024, -0.024690095335245132, -0.015786556527018547, -0.0030127703212201595, -0.011792782694101334, 0.013891907408833504, 0.005056193098425865, -0.0006867013871669769, -0.010405225679278374, -0.0003162543289363384, 0.010982461273670197, 0.006640339270234108, -0.01911017671227455, -0.004455961287021637, 0.008903861045837402, -0.007141427136957645, 0.01265148539096117, -0.018879232928156853, 0.03314078599214554, -0.006342803593724966, 0.008450044319033623, -0.004113774746656418, 0.023749608546495438, 0.0005779860075563192, 0.008673164993524551, -0.0038454949390143156, -0.009744824841618538, 0.028240729123353958, 0.0006924361223354936, 0.01855108141899109, 0.029993105679750443, -0.004030601121485233, 0.0005762972868978977, -0.011672234162688255, 0.0052809035405516624, 0.010412998497486115, -0.006748827174305916, 0.0030266158282756805, -0.0015646370593458414, 0.003231727983802557, -0.007691874168813229, 0.007166106253862381, -0.00232832133769989, -0.018438013270497322, -0.0011406269622966647, 0.025220584124326706, -0.005572755355387926, -0.017988188192248344, 0.015450100414454937, -0.013172255828976631, -0.03717610239982605, 0.020279990509152412, -0.020585868507623672, 0.008843116462230682, -0.024873871356248856, 0.0028529081027954817, 0.016264259815216064, -0.06645065546035767, -0.004939793609082699, 0.006844784133136272, -0.012307366356253624, 0.0007970239967107773, 0.0034241806715726852, 0.007952487096190453, 0.0021018199622631073, -0.006970032583922148, 0.024169161915779114, -0.003032328560948372, -0.0077243950217962265, 0.030566135421395302, 0.03100091964006424, -0.0007352186366915703, -0.010311569087207317, -0.006914163939654827, -0.0066582392901182175, 0.016511116176843643, -0.021350717172026634, -0.010425446555018425, -0.008096085861325264, -0.01511256955564022, -0.00004147202707827091, -0.01345912367105484, 0.02114182710647583, 0.00693096499890089, -0.0036707832477986813, -0.0265323705971241, -0.040140725672245026, -0.007042146287858486, -0.016948744654655457, -0.0011539037805050611, -0.02081679180264473, 0.003932259976863861, -0.01855134405195713, -0.007298371754586697, 0.013436852023005486, -0.0072675952687859535, -0.0011489177122712135, 0.004797762259840965, 0.00035242224112153053, 0.008612578734755516, -0.001552831381559372, 0.0089444350451231, -0.0056354631669819355, 0.034170445054769516, 0.004552658647298813, 0.009747833013534546, 0.018276935443282127, 0.01985734887421131, -0.008608801290392876, 0.00529408548027277, 0.016830753535032272, 0.01805662177503109, 0.026134103536605835, 0.012055004946887493, -0.011099097318947315, 0.006896039936691523, 0.009560779668390751, -0.012349046766757965, -0.0033016186207532883, 0.003681400790810585, -0.0017600086284801364, 0.014877253212034702, -0.005596162751317024, 0.02211609110236168, -0.01409352757036686, 0.014604054391384125, 0.005212022922933102, 0.006407410837709904, -0.012635493651032448, -0.005226082168519497, -0.00387558713555336, -0.012913478538393974, -0.0003075231797993183, 0.0017866241978481412, 0.003733664285391569, 0.008133512921631336, 0.031173529103398323, 0.002759404480457306, -0.021567344665527344, 0.0009420209098607302, -0.012686312198638916, -0.04462462291121483, -0.00018350128084421158, 0.005041925236582756, 0.0020841825753450394, -0.01241047028452158, 0.0058081140741705894, -0.009051097556948662, 0.000338695477694273, 0.012130111455917358, 0.003094105049967766, 0.009969397448003292, -0.03761475905776024, -0.006779310759156942, 0.007830595597624779, 0.009460462257266045, -0.021592825651168823, -0.010485293343663216, -0.017550181597471237, -0.010456951335072517, -0.00968581810593605, 0.003331185318529606, -0.014984812587499619, 0.01711861789226532, 0.012799438089132309, 0.003147302195429802, -0.020587405189871788, 0.0007858141325414181, 0.0029745956417173147, 0.006579581182450056, -0.020787041634321213, 0.06584876775741577, 0.004631713032722473, 0.03255808353424072, 0.020755691453814507, -0.013109755702316761, 0.02159723825752735, -0.006129011511802673, 0.017488732933998108, -0.002766645746305585, 0.017153244465589523, 0.009269986301660538, -0.001677013235166669, 0.008388783782720566, -0.0037721418775618076, 0.026960331946611404, -0.021241433918476105, 0.0016007613157853484, -0.0104231471195817, 0.0005662005860358477, 0.015833593904972076, -0.014484768733382225, 0.01911303400993347, -0.030931714922189713, -0.002414373680949211, -0.03007972612977028, -0.01389913260936737, -0.007493837736546993, 0.017218563705682755, -0.010207144543528557, -0.03528372943401337, -0.010491671971976757, 0.02867564931511879, -0.015964362770318985, 0.0026675048284232616, 0.0028816259000450373, -0.03784368187189102, 0.01327535230666399, -0.01961129531264305, 0.0032879384234547615, 0.0022882206831127405, -0.009030485525727272, -0.0016467070672661066, 0.0031293900683522224, 0.023180905729532242, 0.000963050639256835, 0.005529983900487423, -0.03991350531578064, -0.0017759082838892937, 0.01165233924984932, 0.0013737458502873778, -0.0006972146220505238, 0.010354489088058472, -0.027030693367123604, -0.012108630500733852, 0.04613281041383743, 0.011445138603448868, -0.003704366274178028, 0.011780764907598495, 0.001919817179441452, 0.00939207710325718, -0.005702541209757328, -0.00682317977771163, -0.000218135304749012, 0.005678728222846985, -0.029337003827095032, 0.0012433502124622464, 0.011324213817715645, 0.0006113853305578232, 0.01291809231042862, -0.023638682439923286, -0.03195846080780029, 0.005378019995987415, -0.006941943429410458, -0.02649824693799019, -0.02980775013566017, 0.0007207328453660011, 0.00691830413416028, 0.02052864246070385, -0.020193498581647873, 0.02298274263739586, -0.006913310382515192, 0.009328532963991165, 0.006914766971021891, 0.002179437316954136, -0.021700266748666763, -0.02817985974252224, -0.012045638635754585, 0.008909651078283787, 0.016190173104405403, -0.023522377014160156, 0.00858517736196518, 0.009871997870504856, 0.004052439704537392, 0.003643583506345749, -0.08107923716306686, -0.019190454855561256, -0.0248132161796093, 0.005853472743183374, 0.005900446325540543, 0.016418220475316048, 0.0013821080792695284, -0.018823059275746346, -0.012739555910229683, -0.014515106566250324, 0.01702885329723358, 0.004750428721308708, -0.010158805176615715, -0.015699362382292747, 0.0009854566305875778, -0.009330157190561295, 0.006479538511484861, 0.0031466763466596603, 0.015073563903570175, -0.03826318681240082, -0.00048340996727347374, -0.017741326242685318, 0.002052078954875469, 0.00422495324164629, -0.02907918021082878, 0.019538963213562965, 0.022873084992170334, -0.0012690233998000622, -0.005863063968718052, 0.008936524391174316, -0.0322437584400177, 0.021885454654693604, 0.0024401750415563583, -0.005356787703931332, 0.004169396124780178, -0.00042365374974906445, 0.005323565099388361, 0.012500349432229996, -0.020224660634994507, 0.04953008145093918, -0.013263436034321785, 0.01530935987830162, -0.014735594391822815, 0.0029363511130213737, 0.0012517895083874464, 0.010773656889796257, 0.005385252647101879, -0.016582835465669632, 0.016480596736073494, -0.007339831441640854, 0.0037839612923562527, 0.016277097165584564, -0.007323475554585457, 0.02074028179049492, -0.0040375906974077225, -0.01584094762802124, 0.019331973046064377, 0.0060518523678183556, -0.014342159032821655, -0.017436053603887558, -0.001854702364653349, -0.019292764365673065, -0.014127351343631744, 0.03421133756637573, 0.002739234361797571, 0.00045738520566374063, 0.017725130543112755, -0.01979333907365799, -0.00625194888561964, 0.004004225134849548, 0.020812757313251495, -0.015179254114627838, -0.0037005669437348843, -0.00922513846307993, -0.024073075503110886, -0.01087885070592165, -0.00994635559618473, 0.00838697049766779, -0.004232012201100588, -0.015507052652537823, -0.0027806260623037815, 0.006660517305135727, 0.0018039721762761474, 0.0038054713513702154, 0.0032437904737889767, -0.017030615359544754, 0.00800681859254837, 0.024222547188401222, 0.014621726237237453, -0.009928639978170395, -0.011157755739986897, 0.019097216427326202, 0.020539898425340652, 0.010555514134466648, -0.002501618815585971, -0.035901717841625214, -0.0009991438128054142, -0.02804967574775219, 0.027724266052246094, 0.005757809150964022, -0.00673229293897748, 0.0022092112340033054, -0.022832145914435387, -0.004597505088895559, -0.018696552142500877, 0.014740717597305775, -0.0111920814961195, 0.02645968273282051, -0.013445282354950905, 0.0015400236006826162, -0.01615743525326252, 0.02987661585211754, -0.0021227181423455477, 0.019386854022741318, 0.003956453874707222, 0.015318713150918484, -0.010829182341694832, 0.015551228076219559, 0.072411447763443, 0.02244698256254196, -0.009890918619930744, -0.015543201938271523, 0.0024090944789350033, -0.02688748762011528, -0.014732198789715767, 0.00027532517560757697, 0.006253311410546303, -0.0018821079283952713, 0.010793867520987988, -0.020313521847128868, 0.02070813812315464, -0.00016910582780838013, -0.008624987676739693, -0.012202119454741478, -0.02105095610022545, 0.01565738581120968, 0.010325809009373188, -0.01027296856045723, 0.007121638860553503, -0.03950516879558563, 0.014982063323259354, -0.012879747897386551, -0.003896256908774376, -0.01105720829218626, 0.006329062394797802, -0.008234570734202862, -0.04258560761809349, 0.011734000407159328, 0.00026052212342619896, 0.011667560786008835, -0.00805604737251997, 0.01266079768538475, -0.0029419544152915478, 0.017160378396511078, 0.013073058798909187, -0.025913970544934273, 0.0010855337604880333, -0.0012188635300844908, 0.022906439378857613, -0.013716164976358414, 0.0019752117805182934, -0.0017149336636066437, 0.006470975466072559, 0.002455622423440218, 0.002344791777431965, -0.0068397908471524715, -0.014581330120563507, -0.02150868810713291, -0.0022694997023791075, -0.011257968842983246, 0.01327432319521904, 0.01891483925282955, 0.012745268642902374, -0.0176829993724823, 0.008535090833902359, -0.013514041900634766, -0.008636352606117725, -0.006753960624337196, 0.0012706052511930466, 0.016394544392824173, 0.016840990632772446, -0.017235808074474335, -0.007294770330190659, -0.021720679476857185, -0.014116963371634483, -0.007948535494506359, -0.00638012308627367, -0.0012913078535348177, 0.01696692407131195, 0.005320513620972633, -0.010269006714224815, 0.015393590554594994, -0.03061629645526409, -0.012153083458542824, -0.000058209989219903946, 0.024722890928387642, 0.01740095391869545, -0.028617599979043007, 0.00016172463074326515, 0.009803809225559235, -0.03468400985002518, -0.01633688621222973, 0.0036426291335374117, 0.00475548580288887, 0.00477189663797617, -0.07437402009963989, -0.01457462552934885, -0.039952389895915985, -0.0032218084670603275, -0.020471040159463882, -0.009190275333821774, -0.007869679480791092, -0.03041503205895424, 0.02169695496559143, -0.01105433888733387, 0.01999937742948532, 0.0025268199387937784, -0.006443244405090809, 0.007334358058869839, 0.0076913898810744286, -0.009033124893903732, -0.01166475098580122, 0.00762547180056572, -0.027478499338030815, -0.006315371487289667, 0.007860034704208374, -0.015539736486971378, -0.04333408176898956, -0.005165521055459976, 0.00081985181896016, -0.08118538558483124, -0.0109783336520195, 0.006286279298365116, 0.0033409830648452044, 0.014126981608569622, -0.018526481464505196, -0.002893442288041115, -0.0025699003599584103, -0.01148633286356926, -0.013794760219752789, -0.003055389504879713, 0.007009958848357201, -0.018336428329348564, -0.02238425612449646, -0.019274692982435226, -0.007102726958692074, -0.0011258113663643599, -0.0004696892574429512, 0.021174617111682892, -0.006578254513442516, -0.0019866228103637695, 0.009794073179364204, -0.0107953529804945, -0.0036786766722798347, -0.005975249223411083, -0.0011045881547033787, -0.0037359176203608513, 0.012707495130598545, -0.010515740141272545, -0.012859624810516834, -0.026312297210097313, -0.0027117885183542967, -0.003914266359061003, -0.009352443739771843, -0.012197351083159447, -0.022164829075336456, 0.01425109151750803, 0.008799513801932335, 0.009180529974400997, -0.018555469810962677, -0.0034799270797520876, -0.01105247437953949, -0.04579496383666992, -0.020970642566680908, -0.008869484066963196, -0.02207326889038086, 0.0024932115338742733, -0.013056948781013489, 0.003627476282417774, -0.007018491625785828, 0.003066888079047203, -0.014065757393836975, -0.005035271868109703, 0.010208064690232277, -0.01096847653388977, -0.005294546484947205, -0.007720586843788624, 0.019743379205465317, -0.002067945897579193, -0.005257931537926197, -0.003209898015484214, 0.013389981351792812, 0.015042603015899658, 0.07102037966251373, -0.006374982185661793, -0.004133623093366623, -0.02485724911093712, -0.017487140372395515, 0.004318751394748688, -0.0073304851539433, -0.014342905953526497, 0.00929809920489788, -0.00860624946653843, -0.0018101464956998825, -0.017650246620178223, 0.007850784808397293, 0.010454744100570679, 0.0046658287756145, 0.0060986848548054695, 0.02090424671769142, 0.000821966677904129, -0.007581692188978195, 0.01896068826317787, -0.016642428934574127, 0.005372008308768272, 0.005566874984651804, 0.018358811736106873, -0.011824128217995167, 0.003384937532246113, -0.017832614481449127, -0.0032421955838799477, -0.01033322699368, -0.005166236776858568, 0.008630160242319107, -0.0017914681229740381, -0.00014807371189817786, -0.014799722470343113, 0.019011810421943665, 0.009680627845227718, -0.004114457871764898, 0.009093668311834335, -0.03612561896443367, -0.0029512003529816866, 0.009777819737792015, 0.007939032278954983, -0.0027994359843432903, -0.016944583505392075, 0.02641085535287857, 0.020912259817123413, 0.020420657470822334, -0.01053947489708662, -0.013489297591149807, -0.012493925169110298, 0.033873870968818665, 0.0005350493593141437, 0.016360105946660042, -0.019303761422634125, 0.000981849036179483, -0.0016137659549713135, -0.015736963599920273, 0.01060089934617281, -0.018651487305760384, -0.012880677357316017, -0.00017270678654313087, -0.013151758350431919, 0.023827355355024338, -0.014134909957647324, 0.013484198600053787, -0.0012944689951837063, 0.023619957268238068, -0.0250801183283329, -0.008101297542452812, 0.016696134582161903, 0.02675963006913662, 0.011229943484067917, 0.003635440021753311, 0.010593223385512829, 0.018353624269366264, 0.030023878440260887, 0.006865597330033779, -0.03538215160369873, 0.04045508801937103, -0.004583627916872501, -0.019678395241498947, 0.014446967281401157, 0.013020622543990612, 0.008102072402834892, -0.003461392829194665, -0.01302272267639637, 0.017143985256552696, -0.0024160915054380894, 0.0049353111535310745, 0.010661772452294827, -0.005869738757610321, -0.0028281686827540398, 0.0066623627208173275, 0.0007443795911967754, 0.00680826511234045, 0.03265199437737465, 0.002508696634322405, -0.0007444993825629354, -0.004855550359934568, 0.016068890690803528, 0.0002673818962648511, -0.00762984249740839, 0.0032727508805692196, -0.015685658901929855, -0.006190828047692776, 0.0043655564077198505, -0.024914154782891273, -0.014445526525378227, -0.0036477427929639816, 0.03558913618326187, -0.015069310553371906, 0.0006260131485760212, -0.015571532770991325, 0.021990424022078514, 0.0035204067826271057, 0.013642556965351105, -0.010412640869617462, 0.013462183997035027, -0.022658247500658035, -0.00965563952922821, -0.006651062518358231, -0.005198884755373001, -0.007746209390461445, 0.021403299644589424, 0.0024305833503603935, -0.03254245966672897, -0.00820784829556942, 0.031428012996912, 0.006823467556387186, -0.010302666574716568, 0.02198960818350315, 0.020492296665906906, -0.0044345371425151825, 0.004389528185129166, -0.01151270605623722, -0.006999010685831308, -0.028950542211532593, -0.021497419103980064, 0.005542801693081856, 0.012078674510121346, 0.008097851648926735, -0.009690655395388603, -0.005729610100388527, 0.043077677488327026, 0.00753388786688447, 0.015130477026104927, 0.01866072788834572, 0.02206556126475334, 0.0053712790831923485, -0.0158391036093235, 0.0011527242604643106, -0.0006441285368055105, 0.01799279823899269, -0.007592898327857256, -0.050034575164318085, 0.01688241958618164, 0.02234416827559471, -0.0017702290788292885, -0.028981614857912064, -0.03523489087820053, -0.021183786913752556, 0.018415266647934914, -0.025194521993398666, -0.0032484731636941433, 0.020788734778761864, -0.019954295828938484, -0.002139320131391287, -0.0015642516082152724, 0.005763787776231766, 0.008020544424653053, -0.0022318093106150627, 0.01633283868432045, -0.028670113533735275, 0.008728169836103916, 0.004795760847628117, 0.010515035130083561, -0.010929206386208534, 0.006247268058359623, 0.03386581689119339, 0.013402662239968777, 0.01821218989789486, -0.00409342534840107, -0.007291203364729881, -0.004952337127178907, -0.0004971195012331009, -0.021123547106981277, -0.0049908519722521305, -0.01555153913795948, 0.013338977470993996, 0.00985042005777359, -0.012467475607991219, 0.00775144575163722, 0.003192734671756625, 0.009800739586353302, -0.005191618576645851, -0.014662506058812141, 0.019537221640348434, -0.010349929332733154, 0.0014141552383080125, 0.0028624460101127625, 0.0023823422379791737, 0.012156831100583076 ]
[ 0.1767939180135727, 0.0037538621108978987, 0.37707528471946716, 0.14963485300540924, -0.15276654064655304, -0.07464798539876938, -0.34729328751564026, -0.13848116993904114, -0.41767066717147827, -0.40384718775749207, -0.03268887847661972, 0.25337085127830505, -0.7106331586837769, 0.15583215653896332, 0.3499048948287964, 0.7649120092391968, 0.5382413268089294, 0.5739002823829651, 0.07297658175230026, -0.6932032108306885, -0.16610056161880493, -0.27084580063819885, 0.461542546749115, -0.10443960130214691, 0.5260187983512878, -0.1294989138841629, 0.1296532154083252, 0.5256063938140869, 0.5025782585144043, -0.16053591668605804, -0.038122184574604034, 0.2726052403450012, 0.20685233175754547, 0.10921492427587509, 0.05223333090543747, 0.09385447949171066, -0.3988710939884186, -0.26585638523101807, -0.1103706806898117, -0.06588700413703918, -0.6362906098365784, 0.07457562536001205, -0.10577132552862167, 0.2536112070083618, -0.20707501471042633, 0.15861372649669647, -1.1284250020980835, 0.6377600431442261, -0.43804073333740234, 0.20132432878017426, -0.24288035929203033, 0.35934457182884216, 0.07714235782623291, -0.06074891239404678, 0.5216608643531799, -0.05597814545035362, -0.9486857652664185, -0.06792902946472168, 0.06426700949668884, -0.5508809089660645, -0.2717036306858063, -0.055865395814180374, -0.034833136945962906, 0.10569373518228531, 0.21148961782455444, 0.6099289655685425, -0.37556007504463196, -0.5038771033287048, -0.8657521605491638, 0.22864852845668793, 0.21084064245224, -0.4600673317909241, -0.5526046752929688, 0.478232741355896, -0.2021753191947937, -0.048989761620759964, -0.7393312454223633, -0.07595685124397278, 0.0558624193072319, 0.6339548826217651, -0.06641172617673874, 0.5079188942909241, 0.39749255776405334, 0.40817755460739136, 0.5761253833770752, 0.4005852937698364, -0.2780521512031555, 1.3023706674575806, -0.3759826719760895, -0.0015193757135421038, 0.10025881230831146, 0.12021762877702713, 0.32229864597320557, -0.15129756927490234, -0.07133109867572784, -0.025566063821315765, -0.09875205904245377, -0.4004831314086914, -0.0009162039496004581, 0.24335099756717682, -0.3016265630722046, -0.08133271336555481, -0.16782936453819275, -0.45780256390571594, -0.4867822229862213, -0.028162507340312004, -0.5244836807250977, -0.39252227544784546, -0.5560534000396729, 0.3205834925174713, -0.5994588732719421, -0.0027598384767770767, -0.2732665538787842, -0.36003321409225464, 0.3183225393295288, 0.08869553357362747, -0.018728751689195633, -0.0374763086438179, 0.040354061871767044, 0.1412849724292755, -0.27803313732147217, 0.95821613073349, 0.029082801192998886, 0.38199806213378906, 0.13002528250217438, -0.4045484662055969, 0.1362658590078354, -0.08303964883089066, -0.09204880148172379, 0.6841428875923157, 0.4532000720500946, 0.5841414332389832, -0.006951292511075735, 0.15497444570064545, -0.3618086278438568, -0.1920151710510254, 0.19390715658664703, 0.3195382058620453, 0.5935190916061401, -0.026015257462859154, -0.7042779922485352, -0.12063142657279968, -0.36336979269981384, -0.052563074976205826, 0.015832901000976562, -0.4362034201622009, -0.3035160005092621, 0.21265354752540588, -0.24438144266605377, -0.14113441109657288, 0.09005696326494217, -0.27554401755332947, -0.17244994640350342, -0.06437531113624573, -0.053182441741228104, 0.30428463220596313, 0.1366414874792099, -0.24796976149082184, 0.015361286699771881, -0.33478644490242004, 0.09220392256975174, -0.20747478306293488, -0.09360503405332565, 0.06976335495710373, 0.2767247259616852, 0.000042771873268065974, -0.00925141479820013, 0.3772203028202057, 0.29019278287887573, -0.05905713886022568, 0.07802523672580719, -0.5247194170951843, -0.16599847376346588, -0.5784112215042114, 0.18732596933841705, -0.3121420741081238, 0.10872546583414078, -0.19455018639564514, 0.06483207643032074, -0.058625977486371994, -0.7915951013565063, 0.15979883074760437, -0.42706480622291565, -0.565621018409729, 0.1502889096736908, 0.201778382062912, 0.9597508311271667, -0.3630838096141815, -0.2228407859802246, -0.11056898534297943, -0.30564144253730774, 0.04332807660102844, 0.6975064277648926, -0.24103964865207672, 1.5753144025802612, -0.3423422574996948, -0.22976575791835785, 0.7121541500091553, 0.27131161093711853, -0.11778882145881653, -0.5926449298858643, 0.057505473494529724, 0.3378989100456238, -0.5629000067710876, -0.9687397480010986, 0.122954361140728, -0.08982527256011963, -0.1391090303659439, 0.21888965368270874, 0.12292113900184631, 0.3925172984600067, -0.37238165736198425, -0.008964715525507927, -0.33947059512138367, 0.5101704597473145, -0.9509066343307495, 0.07080107927322388, 0.08537079393863678, -0.09025783836841583, 0.3050589859485626, 0.2156132310628891, -0.4686056077480316, 0.3209499716758728, 1.0806646347045898, -0.5156325101852417, 0.6232351064682007, 0.5146479606628418, 0.2297067493200302, 0.7032010555267334, -0.13072428107261658, 0.2942437529563904, -0.6029828190803528, 0.08733098953962326, -0.38887786865234375, -0.07793078571557999, -0.25381505489349365, 0.25253450870513916, -0.10314537584781647, -0.39597225189208984, -0.31094858050346375, -0.018097292631864548, 0.19477806985378265, -0.6509160995483398, -0.16703034937381744, 0.14996880292892456, -0.545740008354187, 0.012683131732046604, 0.28480374813079834, -0.6741493344306946, -0.05908288061618805, -0.012793025933206081, 0.5912097096443176, 0.1367458701133728, -0.31670939922332764, -0.1027662605047226, -0.06946846097707748, -0.2939819395542145, -0.25152504444122314, 0.27753791213035583, -0.3271113932132721, -0.16156955063343048, 0.22395431995391846, 0.05708358436822891, 0.4046468138694763, -0.1288960576057434, -0.12387996166944504, -0.3994898796081543, -0.21333838999271393, 1.1585148572921753, 0.6667304635047913, 1.2745108604431152, -0.7059962153434753, -0.8065453767776489, -0.33570411801338196, -0.21876206994056702, -0.7595930099487305, 0.17023083567619324, 0.44690167903900146, -0.24986034631729126, -0.7858871817588806, -0.1022391989827156, 0.05379263311624527, 0.8572349548339844, 0.07182253897190094, -0.4729563891887665, 0.11662294715642929, -0.42987531423568726, -0.2777797281742096, 0.15224941074848175, -0.7340008020401001, 0.1300140619277954, -0.011584208346903324, -0.40207257866859436, -0.2746019661426544, 0.04230153188109398, 0.14799001812934875, 0.030077746137976646, 0.633596658706665, 0.9074484705924988, 0.007220781408250332, -0.03672996535897255, -0.041437793523073196, -0.4349479675292969, 0.13426503539085388, 0.10283198952674866, -0.10166311264038086, 0.020868908613920212, 0.05122078210115433, -5.768717288970947, 0.2036404311656952, 0.24765293300151825, -0.22980329394340515, 0.6379150748252869, -0.12445221841335297, 1.2143855094909668, -0.1746118813753128, 0.3421631455421448, 0.17499320209026337, -0.15984217822551727, 0.2365303784608841, -0.1374354064464569, -0.2086206078529358, -0.018045658245682716, 0.044314343482255936, 0.01898070052266121, -0.0797668844461441, 0.8528326153755188, 0.14733904600143433, -0.009056380949914455, -0.18737755715847015, 0.08329468220472336, 0.4293726682662964, -0.13168717920780182, -0.2368534952402115, -0.9776172041893005, 0.023327460512518883, -0.3033437728881836, -0.11552321165800095, -0.39604300260543823, -0.5523632168769836, -0.2313973754644394, -0.42593008279800415, 0.3574278652667999, -0.49520841240882874, 0.06345117092132568, -0.1565646082162857, -0.22987814247608185, -0.32318538427352905, 0.5564911365509033, 0.5805869698524475, -0.0814397931098938, 0.11747949570417404, 0.5845087170600891, -0.17493924498558044, -0.2986729145050049, -0.5215857625007629, -0.3092496693134308, 0.8053598403930664, 0.051659248769283295, -0.3259437680244446, 0.2406863123178482, 0.3416312038898468, 0.7046859264373779, 0.42694559693336487, 0.11333680152893066, 0.2277655154466629, -0.5070194602012634, 0.30923062562942505, 0.07055612653493881, -0.1416294276714325, -0.399131178855896, -0.7295312881469727, -0.1328781694173813, 0.5106580257415771, -0.8501830101013184, -0.34765252470970154, 0.30684614181518555, -0.3575238883495331, -0.39842653274536133, 0.1547906994819641, 0.1485576033592224, -0.6740840673446655, 0.7722784876823425, -0.4811161756515503, 0.07406431436538696, -0.011095141060650349, 0.20134443044662476, 0.07528150826692581, -0.5144234895706177, 0.049169424921274185, 0.03981234133243561, -0.027022482827305794, -0.04392458125948906, -0.4479348957538605, -0.42316874861717224, -0.18426595628261566, -0.3396773040294647, 0.14028900861740112, 0.39200305938720703, 0.02915230393409729, 0.08783251792192459, 0.694961428642273, -0.31546834111213684, 0.05310570448637009, 0.13377569615840912, 0.658351480960846, 0.3794456422328949, 0.24490833282470703, 0.888861358165741, 0.29362380504608154, -0.8444888591766357, -0.30408045649528503, -0.17861109972000122, 0.03618929907679558, -0.37411293387413025, 0.30546557903289795, 0.54198157787323, -0.7038609981536865, -0.06751880049705505, 0.4034402668476105, -0.4296110272407532, -0.5375295877456665, 0.8106544017791748, 0.06240944564342499, -0.44374531507492065, 0.26166999340057373, 0.5741181373596191, -0.5928595066070557, 0.2284374237060547, 0.5203049778938293, -0.6376562714576721, 0.47530558705329895, -0.03241491690278053, -0.06813768297433853, 0.3651426136493683, 0.6313073039054871, -0.5766400694847107, -0.3729479908943176, 0.34866249561309814, -0.03585970401763916, 0.008371494710445404, -0.41173794865608215, 0.03336745500564575, -0.6488651037216187, -0.4854104518890381, 0.4253193140029907, 0.4567311704158783, -0.20079703629016876, -0.05010135471820831, -0.08041121065616608, -0.12528181076049805, -0.04085057973861694, 0.7472696900367737, 0.05874093249440193, 0.03129838779568672, 0.6507521271705627, -0.3244488537311554, -0.11931809782981873, 0.2566210627555847, -0.37501758337020874, 0.29175490140914917, 0.395230233669281, 0.1599719226360321, -0.23400530219078064, 0.5480668544769287, 0.5319567322731018, 0.5005743503570557, -0.7442465424537659, 0.2258279025554657, 0.3514886200428009, -1.1173107624053955, 0.17028437554836273, -0.125043585896492, -0.5063076615333557, 0.11943602561950684, -0.24733394384384155, -0.2800781726837158, -0.05177424103021622, -0.3692474663257599, -0.29418429732322693, 0.1401117444038391, 0.15797503292560577, -0.17288120090961456, -0.32218146324157715, -0.2502097189426422, 0.1111973449587822, -0.1437932252883911, 0.09907421469688416, 0.0038189166225492954, -0.6589735746383667, 0.05865238979458809, -0.020436231046915054, 0.14151762425899506, 0.07100492715835571, -0.032163381576538086, -0.11185991019010544, 0.11101144552230835, -0.39796778559684753, 0.024144580587744713, 0.33818209171295166, 0.16620098054409027, -0.17355316877365112, 0.04808416962623596, 0.4177643954753876, 0.3288266658782959, 0.3177087604999542, -0.1797960251569748, -0.31051015853881836, 0.055787619203329086, 0.30406537652015686, -0.25742363929748535, 0.15179266035556793, 0.3582579791545868, 0.2869885563850403, 0.14162322878837585, 0.32846999168395996, -0.14673437178134918, -0.3823065459728241, 0.1863500475883484, -0.37393707036972046, 0.3200075924396515, 0.002513701794669032, -0.21744821965694427, 0.052907709032297134, 0.3264593780040741, -0.230970099568367, -0.12817099690437317, 0.3278862237930298, 0.5440847873687744, -0.011374140158295631, -0.030501266941428185, -0.1186690703034401, -0.5356451869010925, 0.5267648100852966, 0.3110813498497009, -0.7840790152549744, 0.6364715695381165, -0.09801635146141052, -0.5126393437385559, -0.3688124418258667, -0.0829702615737915, 0.5893183350563049, -0.5263010859489441, 0.006989345885813236, -0.3869346082210541, 0.14522092044353485, -0.002986039500683546, 0.37877246737480164, 0.21797697246074677, 0.6401000618934631, -0.27763572335243225, -0.17807939648628235, -0.07696538418531418, 0.5307649970054626, 0.41914916038513184, -0.6857335567474365, -0.36586806178092957, -0.2504212260246277, 0.6549977660179138, -0.19481836259365082, 0.22930510342121124, 0.3068099915981293, 0.8839331269264221, 0.26833683252334595, -0.3192847669124603, -0.13066422939300537, -0.4063144624233246, 0.44388362765312195, -0.5954045057296753, 0.371817946434021, -0.5065358281135559, 0.04434683173894882, 0.3169853389263153, -0.18492935597896576, -0.4411337077617645, -0.45434442162513733, 0.47055956721305847, -0.11903020739555359, -0.6244184374809265, 0.02008874900639057, 0.7171101570129395, -0.013914860785007477, 0.002394109033048153, 0.11816877126693726, 0.049887701869010925, -0.4995650351047516, 0.5333205461502075, 0.19662703573703766, -0.5416133999824524, -0.6649094820022583, 0.5338479280471802, -0.26539167761802673, 0.7692609429359436, -0.69117271900177, -0.29391545057296753, -0.5855669975280762, -0.23742009699344635, -0.08933427929878235, -0.15610811114311218, 0.18902648985385895, -0.9045369029045105, -0.6878178119659424, -0.14391326904296875, 0.17798101902008057, 0.18643949925899506, 0.1773621141910553, 0.09487194567918777, 0.41912561655044556, -0.3809327185153961, 0.45932719111442566, 0.7203139662742615, -0.31124159693717957, 0.1273702085018158, -0.02588682435452938, -0.09173939377069473, -0.32537490129470825, -0.2235049158334732, -0.09215561300516129, -0.10607077926397324, -0.051655363291502, -0.02961997501552105, -0.07364385575056076, -0.30243292450904846, 0.19253818690776825, 0.37962448596954346, -0.044601816684007645, 0.377525269985199, 0.5167434811592102, 0.14383891224861145, 0.3975085914134979, 0.07536674290895462, 0.19412189722061157, -0.24616387486457825, 0.19418713450431824, 0.3073022961616516, 0.13232414424419403, 0.40000373125076294, 0.4857964515686035, 0.5066462755203247, 0.46367383003234863, 0.22191418707370758, 0.47690460085868835, 0.3771965205669403, 0.24796262383460999, -0.33218005299568176, -0.508124053478241, -0.16884911060333252, 0.0912720113992691, 0.8036640286445618, 0.4688025116920471, -0.4420204758644104, -0.11493996530771255, 0.23718836903572083, 0.49035778641700745, 0.15265074372291565, -0.06250998377799988, -0.34435731172561646, 0.6843109726905823, 0.31757238507270813, -0.04605649784207344, -0.3476509749889374, 0.3021467924118042, -0.9323248863220215, 0.6874551773071289, 0.6339396834373474, -0.22886231541633606, -0.6253767609596252, 0.22758927941322327, -0.6295774579048157, 0.6270849108695984, -0.01554112508893013, 0.8407898545265198, -0.23200315237045288, 0.08216162025928497, 0.06921842694282532, -0.2871801555156708, 0.6726198792457581, -0.07697601616382599, -0.18055462837219238, 0.35295823216438293, -0.5765498280525208, 0.1469818353652954, 0.12564417719841003, -0.24801307916641235, 0.05874812975525856, -0.09321057051420212, 0.19035179913043976, 0.5747087597846985, -0.42470812797546387, 0.18921256065368652, -0.3184753954410553, -0.27355626225471497, -0.3544619381427765, 0.03280434012413025, -0.4779168963432312, -0.1557655930519104, -0.1982169896364212, 0.2672120928764343, -0.31673094630241394, -0.4766085147857666, 0.6199787855148315, 0.09606216102838516, 0.05115783214569092, 0.24221768975257874, 0.25390586256980896, 0.20228324830532074, 0.2707405984401703, 0.24472802877426147, -0.2770209014415741, 0.3586151897907257, -0.12282954901456833, 0.27945423126220703, -0.11570414155721664, 0.517688512802124, -0.6423683166503906, 0.12146618962287903, -0.5897863507270813, -0.19060522317886353, 1.1235089302062988, 0.7861952781677246, -0.3185037076473236, 0.09996854513883591, 0.529338538646698, 0.37055736780166626, 0.3864907920360565, -0.4875485599040985, -0.22336627542972565, -0.7387288212776184, -0.3339501619338989, -0.42558708786964417, 0.21696487069129944, 0.24145370721817017, -0.12112602591514587, -0.017981871962547302, 0.4362733066082001, 0.21692082285881042, -0.7872520089149475, 0.37549832463264465, 0.01672757789492607, -0.02081489935517311, -0.8450024724006653, -0.05101269856095314, -0.003984266426414251, 0.6382126212120056, -0.7704076766967773, 0.2785798907279968, 0.323652058839798, -0.009744767099618912, 0.4438380002975464, -0.008788076229393482, 0.01153748482465744, -0.3717571496963501, 0.16599041223526, -0.39402374625205994, -0.24327990412712097, -0.9178141951560974, -0.9325138330459595, 0.20740626752376556, 0.36132657527923584, -0.706787645816803, -0.3612390458583832, -0.11918210983276367, -0.016708480194211006, -0.16931185126304626, 0.2435375601053238, 0.30017006397247314, -0.035942722111940384, 0.46344757080078125 ]
Single-stranded DNA-binding protein (SSB) plays an important role in DNA metabolism, such as in DNA replication, repair, and recombination, and is essential for cell survival. We characterized the single-stranded DNA (ssDNA)-binding properties of Pseudomonas aeruginosa PAO1 SSB (PaSSB) by using fluorescence quenching measurements and electrophoretic mobility shift analysis (EMSA). Analysis of purified PaSSB by gel filtration chromatography revealed a stable tetramer in solution. In fluorescence titrations, PaSSB bound 22-32 nucleotides (nt) per tetramer depending on salt concentration. Using EMSA, we characterized the stoichiometry of PaSSB complexed with a series of ssDNA homopolymers, and the size of the binding site was determined to be 29 ± 1 nt. Furthermore, EMSA results indicated that the dissociation constants of PaSSB for the first tetramer were less than those for the second tetramer. On the basis of these biophysical analyses, the ssDNA binding mode of PaSSB is expected to be noncooperative.
[ 0.0017922427505254745, 0.01616324856877327, -0.005699175409972668, 0.02044530212879181, 0.011797495186328888, -0.0066864644177258015, 0.010756458155810833, 0.0008043944835662842, -0.012200930155813694, -0.007504854816943407, -0.004825678654015064, 0.008741391822695732, -0.03092246875166893, -0.0035821818746626377, -0.006382554769515991, -0.029210902750492096, -0.010656433179974556, -0.00302742887288332, 0.007234039716422558, 0.014716756530106068, -0.004098658449947834, -0.008230376988649368, 0.009456740692257881, 0.01107302401214838, 0.025471579283475876, 0.00025250273756682873, 0.028741538524627686, -0.003050881437957287, -0.032551176846027374, 0.007091345731168985, -0.005574776325374842, -0.023374058306217194, 0.021900292485952377, 0.008057689294219017, 0.003756638616323471, 0.01315220445394516, -0.004039453342556953, 0.02723115310072899, 0.02255913056433201, -0.0044439383782446384, -0.01753144897520542, -0.01179596409201622, 0.0018532176036387682, 0.02176298201084137, -0.007596959359943867, -0.005535290576517582, 0.0038896806072443724, 0.01392692793160677, 0.008082126267254353, 0.005869884509593248, -0.007726943586021662, -0.003750411793589592, -0.006176342256367207, 0.0197756290435791, -0.005929197650402784, -0.03997790068387985, 0.01717306673526764, -0.018509477376937866, -0.019096720963716507, -0.007823971100151539, 0.034319549798965454, 0.013953985646367073, 0.02605958841741085, 0.0018060160800814629, -0.009328499436378479, -0.06700783967971802, 0.01864967867732048, -0.028258636593818665, -0.010238985531032085, -0.011945737525820732, 0.004678717814385891, 0.0068861618638038635, -0.0018936963751912117, 0.004901271313428879, 0.008505327627062798, -0.028268873691558838, -0.00761719373986125, 0.0020095640793442726, -0.0034172250889241695, 0.022251758724451065, -0.0033855056390166283, -0.0074933720752596855, 0.01646759733557701, 0.011733844876289368, 0.02318638190627098, 0.004965304397046566, -0.028013702481985092, -0.019099228084087372, 0.0025242725387215614, 0.008005768060684204, 0.023646235466003418, 0.017874501645565033, 0.02593354508280754, 0.0016570384614169598, 0.016185525804758072, 0.025203192606568336, -0.018156765028834343, -0.02866842783987522, 0.022146420553326607, -0.020729752257466316, -0.020879847928881645, 0.009801727719604969, 0.013749177567660809, -0.011090654879808426, 0.021911494433879852, 0.00674919318407774, 0.009018169716000557, 0.0339793786406517, -0.010340406559407711, 0.005091001279652119, 0.026498964056372643, 0.00781567394733429, -0.026298774406313896, 0.0011734135914593935, -0.0035698628053069115, 0.010302356444299221, -0.016256287693977356, -0.001596581656485796, 0.013433564454317093, -0.012204233556985855, -0.011557519435882568, -0.004437568131834269, 0.00005240878090262413, 0.011644210666418076, 0.007918908260762691, 0.018465613946318626, -0.01986175775527954, 0.006275889929383993, -0.003168544266372919, 0.01327577419579029, -0.007624782621860504, 0.007216864265501499, -0.040909286588430405, -0.0008049635216593742, -0.010302905924618244, -0.008559729903936386, -0.008177587762475014, 0.006706366315484047, 0.00788152776658535, -0.011966452933847904, 0.0026550355833023787, 0.01006290502846241, 0.0034277040977030993, 0.010610871016979218, 0.002800095360726118, 0.004428333602845669, 0.0012138423044234514, -0.007901634089648724, 0.010360310785472393, 0.018613150343298912, 0.03282160311937332, 0.0005705542862415314, -0.01697622984647751, -0.010751044377684593, 0.011838633567094803, -0.0009147112723439932, -0.01299683190882206, -0.004289115313440561, 0.007317282725125551, 0.015513300895690918, -0.01459768321365118, -0.00642329640686512, 0.0017310618422925472, 0.008721212856471539, 0.0004778887378051877, -0.013868826441466808, 0.013336362317204475, -0.017262069508433342, -0.019462624564766884, 0.009502094238996506, -0.003792158095166087, 0.02377476915717125, 0.0008661334868520498, 0.00621044309809804, -0.01660029962658882, 0.0057727075181901455, -0.00498835276812315, 0.008719531819224358, -0.02470792457461357, 0.06668687611818314, -0.024906044825911522, 0.022587895393371582, -0.01270375307649374, -0.000453396700322628, 0.013888713903725147, -0.018214594572782516, 0.018631286919116974, -0.012988721020519733, -0.012211238965392113, -0.0027656173333525658, 0.0006964514032006264, 0.015493519604206085, -0.032465867698192596, 0.00936177559196949, 0.012314935214817524, 0.002318750135600567, 0.020554522052407265, 0.002732981462031603, 0.012237152084708214, 0.0032301652245223522, 0.03490195423364639, -0.028484921902418137, 0.04263880103826523, -0.007352722343057394, 0.01069718413054943, 0.01692616567015648, 0.012835648842155933, 0.006529994308948517, -0.015572555363178253, 0.012457264587283134, 0.020524434745311737, -0.013912433758378029, -0.00957615114748478, -0.004742749035358429, -0.020570043474435806, 0.008603895083069801, -0.03249584138393402, 0.011977550573647022, -0.008426545187830925, -0.012106524780392647, 0.0022131935693323612, -0.023770293220877647, -0.010504516772925854, -0.030171871185302734, 0.003970311488956213, 0.007443261332809925, -0.012895332649350166, 0.014167144894599915, -0.030280644074082375, 0.01140088215470314, 0.005258005578070879, -0.02172667533159256, -0.012164218351244926, -0.007820183411240578, 0.0019121014047414064, -0.004954489879310131, 0.00996689684689045, 0.02041858807206154, 0.005119145382195711, -0.009447192773222923, -0.0065011195838451385, 0.007855270057916641, -0.00830987561494112, 0.005417877342551947, 0.03702874854207039, 0.012686199508607388, -0.03400185704231262, 0.013944815844297409, 0.04035358875989914, 0.006068531423807144, 0.007071792613714933, 0.02137393318116665, -0.012395470403134823, -0.013966601341962814, 0.0003775814548134804, -0.008566551841795444, 0.03959248960018158, 0.005459615029394627, 0.023908939212560654, -0.01054164208471775, -0.003955670166760683, 0.0038467738777399063, -0.030544579029083252, 0.0292303878813982, 0.007288741413503885, 0.03235211968421936, 0.006172657944262028, 0.031139757484197617, -0.02370874211192131, -0.021794475615024567, 0.005623719189316034, -0.010917683131992817, 0.008428000845015049, -0.08174210786819458, -0.004902450833469629, 0.0007819156162440777, -0.019839409738779068, 0.011682757176458836, 0.017617061734199524, -0.005898135714232922, -0.03115229494869709, -0.013472553342580795, -0.01352021936327219, 0.007260477636009455, -0.005141011439263821, -0.010573334991931915, -0.019448786973953247, 0.020560750737786293, -0.010417673736810684, 0.013307470828294754, -0.034790970385074615, 0.023501556366682053, -0.02105635777115822, -0.007367830723524094, -0.005192993208765984, -0.011876236647367477, -0.000655733747407794, -0.026217512786388397, -0.026586266234517097, 0.023098351433873177, -0.021653737872838974, 0.02098884806036949, 0.01495455764234066, 0.0032759932801127434, -0.0076418002136051655, -0.015366282314062119, -0.032078616321086884, 0.002534412080422044, 0.023531220853328705, -0.015082480385899544, -0.016551323235034943, -0.032274119555950165, 0.005173604004085064, -0.0106705566868186, 0.005848017521202564, -0.022886810824275017, 0.008465909399092197, 0.0004381244070827961, 0.019648507237434387, -0.0321681872010231, 0.017673728987574577, 0.006509821861982346, 0.0038117310032248497, -0.03325756639242172, -0.005071214400231838, 0.01068781316280365, 0.015485347248613834, -0.010548710823059082, -0.006791259162127972, -0.0068250903859734535, 0.004176345653831959, -0.013226240873336792, -0.016734592616558075, -0.029731454327702522, -0.009178821928799152, 0.005063032731413841, -0.0053742919117212296, -0.010713860392570496, 0.001137969666160643, 0.014917855150997639, -0.007299368269741535, -0.010277779772877693, 0.002663656137883663, 0.01552555337548256, -0.02878168225288391, -0.008819148875772953, -0.004866484552621841, 0.0105656823143363, -0.009594114497303963, -0.009471182711422443, -0.014285233803093433, 0.009920965880155563, -0.010127462446689606, 0.018443388864398003, -0.000252548954449594, -0.014688581228256226, 0.011257965117692947, -0.019164936617016792, -0.01987318880856037, 0.008163761347532272, 0.036302149295806885, 0.002015769947320223, -0.01668676920235157, 0.004591427743434906, -0.005729524418711662, 0.014535263180732727, 0.010130634531378746, -0.014967115595936775, -0.008163896389305592, -0.022907085716724396, -0.007438148371875286, 0.0016804984770715237, 0.007414320018142462, -0.024537909775972366, 0.00933060236275196, 0.015731874853372574, -0.012567347846925259, -0.02136227861046791, 0.013951960019767284, -0.00829397514462471, -0.013953695073723793, 0.03017684444785118, -0.004698255565017462, -0.02313511073589325, -0.006694892421364784, -0.004371414892375469, 0.03022155538201332, 0.01429582666605711, -0.011244232766330242, -0.028181269764900208, 0.016142353415489197, 0.07230263948440552, 0.01705509051680565, -0.004289031494408846, -0.012000104412436485, 0.01803600788116455, -0.015251025557518005, -0.0026800234336405993, 0.0022428352385759354, 0.0057323891669511795, -0.020931895822286606, 0.012263856828212738, 0.040363699197769165, 0.0131222577765584, 0.004536491818726063, -0.019287753850221634, 0.04478445276618004, -0.03816299885511398, -0.012698688544332981, -0.02267855405807495, 0.002584518864750862, -0.022296175360679626, -0.0518125519156456, -0.025867674499750137, 0.03268645703792572, -0.010993524454534054, -0.014262489043176174, 0.03311567008495331, -0.013917915523052216, -0.004352062940597534, 0.0077403225004673, 0.021449655294418335, -0.012610107660293579, -0.00482122041285038, 0.01755308359861374, 0.00946543924510479, -0.019717158749699593, 0.010664524510502815, 0.024183649569749832, -0.021749189123511314, -0.008903183043003082, 0.0005017183721065521, -0.017969198524951935, -0.023489588871598244, 0.010120099410414696, 0.005890358239412308, 0.025432191789150238, 0.012892482802271843, -0.007400624454021454, -0.00749953743070364, -0.012086102738976479, 0.006941673345863819, -0.0012714867480099201, 0.009875346906483173, 0.00882281269878149, 0.03231791406869888, -0.010097352787852287, 0.033770933747291565, -0.00680309534072876, 0.009491011500358582, 0.0058973403647542, -0.020827049389481544, 0.03031260147690773, 0.025863084942102432, -0.02228463627398014, 0.0019527736585587263, -0.014460394158959389, -0.000291615491732955, -0.005256604868918657, -0.02866608463227749, 0.00519079715013504, 0.04128339886665344, 0.011057691648602486, -0.0013858499005436897, -0.009984798729419708, -0.017519012093544006, -0.010287412442266941, 0.012417346239089966, -0.007759375032037497, -0.0036028907634317875, -0.015389760956168175, -0.005702110007405281, 0.01371625903993845, 0.0007246732711791992, 0.0048692235723137856, -0.002568512223660946, -0.011187943629920483, 0.000984648708254099, -0.07476174086332321, 0.015219775959849358, -0.011765047907829285, -0.009258302859961987, -0.002444302197545767, 0.007172752637416124, -0.0025555570609867573, 0.009634965099394321, -0.0002039215760305524, 0.010908019728958607, 0.0025339885614812374, -0.017217548564076424, 0.026293504983186722, -0.02882912941277027, 0.009289956651628017, 0.01776220090687275, 0.02584989182651043, -0.007867341861128807, -0.017869586125016212, 0.0025799896102398634, -0.018218109384179115, 0.0050033931620419025, -0.009691223502159119, 0.010703845880925655, -0.009480736218392849, -0.0813150703907013, -0.01663850247859955, -0.01923206076025963, 0.0004991646856069565, -0.016935694962739944, -0.008572526276111603, -0.013505851849913597, -0.010504735633730888, -0.02621549181640148, -0.01776963286101818, 0.03908214718103409, 0.03347816690802574, 0.0036675601731985807, -0.027682676911354065, 0.01359079871326685, -0.010601013898849487, 0.003931356593966484, 0.005483175627887249, 0.018576618283987045, -0.006891862489283085, 0.028377637267112732, -0.007695309817790985, -0.011956069618463516, -0.007637648843228817, -0.013386035338044167, -0.02837906964123249, 0.007684092968702316, 0.00848554726690054, 0.02394128404557705, 0.004272909834980965, -0.010747227817773819, -0.009277821518480778, -0.0016071705613285303, 0.01754153147339821, 0.0022602244280278683, -0.014981988817453384, 0.0010880478657782078, -0.006787504535168409, 0.016477497294545174, -0.025524362921714783, -0.008207958191633224, 0.02026640996336937, -0.01283613033592701, 0.02748468890786171, 0.014684825204312801, -0.027263877913355827, 0.002841099863871932, -0.003232221584767103, 0.009784186258912086, -0.02119075506925583, 0.01193704642355442, -0.011753115803003311, 0.008612176403403282, -0.0076628392562270164, -0.009572247043251991, -0.017677826806902885, 0.0028464493807405233, 0.007823808118700981, -0.002985538449138403, -0.0024664776865392923, -0.0016200257232412696, 0.004837609361857176, 0.007924928329885006, 0.0716378465294838, -0.008588426746428013, 0.013536278158426285, -0.007647084072232246, -0.012704726308584213, 0.00268282787874341, -0.005111213773488998, -0.0025698011741042137, 0.002296019345521927, -0.012554452754557133, -0.015450546517968178, -0.0044613005593419075, -0.010617056861519814, 0.014699850231409073, 0.012708432972431183, -0.007479303516447544, -0.01931498944759369, -0.01744958572089672, -0.03572959080338478, 0.028532445430755615, -0.004332208074629307, 0.02614356204867363, 0.02073446474969387, 0.05102992802858353, 0.013376936316490173, -0.01381663791835308, -0.021407339721918106, 0.013771247118711472, 0.02227533608675003, -0.006171835120767355, 0.01843842677772045, -0.017452096566557884, 0.00357244024053216, 0.03140338510274887, 0.008715121075510979, 0.014198198914527893, 0.007324135862290859, -0.0013122673844918609, -0.024777298793196678, 0.01971687749028206, -0.004703726153820753, -0.013554577715694904, -0.004443119280040264, -0.006219015456736088, 0.015143252909183502, -0.03314964473247528, 0.022794783115386963, 0.006910095922648907, -0.009575488045811653, 0.0034869792871177197, 0.043640632182359695, -0.0014472058974206448, 0.015004712156951427, 0.012003481388092041, -0.008791844360530376, -0.0036672758869826794, -0.007835116237401962, 0.004550255835056305, -0.019513964653015137, 0.012475015595555305, 0.005757523700594902, -0.0166263896971941, -0.01132461242377758, -0.014675751328468323, 0.027505218982696533, -0.018297642469406128, -0.035873278975486755, -0.007965783588588238, 0.05824156478047371, 0.013063830323517323, 0.013125153258442879, -0.026903577148914337, 0.006673998665064573, -0.016820918768644333, 0.006388145498931408, -0.006722033955156803, 0.0018202648498117924, -0.026319896802306175, 0.01794515922665596, -0.018647441640496254, -0.006931241601705551, 0.016289612278342247, -0.012242864817380905, -0.023290174081921577, -0.02084861882030964, 0.014657288789749146, 0.022412599995732307, 0.003339951392263174, -0.011033807881176472, 0.013911910355091095, 0.017242634668946266, 0.012427512556314468, 0.0030500092543661594, 0.02046859636902809, 0.004997380077838898, 0.03413362428545952, 0.025442790240049362, 0.010120357386767864, 0.007160638924688101, 0.0041538383811712265, 0.03157755360007286, -0.030722644180059433, -0.03133362531661987, -0.020112447440624237, -0.025670506060123444, -0.007935838773846626, 0.04963195323944092, -0.024438153952360153, 0.02165263518691063, 0.014510022476315498, -0.019066210836172104, -0.003663701703771949, 0.013137934729456902, 0.0002696770243346691, 0.005878679919987917, 0.03734993562102318, -0.031019827350974083, 0.0065011437982320786, -0.003556168871000409, -0.004202672280371189, 0.005356281995773315, -0.01276632770895958, -0.004777291789650917, 0.013502697460353374, -0.019448665902018547, -0.009931443259119987, -0.007825640961527824, 0.012382482178509235, 0.0037143509835004807, 0.022482361644506454, 0.017314765602350235, -0.019925734028220177, 0.005118361208587885, -0.01794024184346199, 0.008436450734734535, 0.02244933322072029, 0.013453273102641106, -0.013950737193226814, -0.009430775418877602, -0.011221126653254032, 0.03071305900812149, -0.01583542488515377, -0.0058761416003108025, -0.000060536316595971584, 0.008098455145955086, -0.010490091517567635, 0.006808923557400703, 0.01357015036046505, 0.0038753305561840534, -0.012553930282592773, 0.007331491447985172, 0.01750086061656475, -0.024147527292370796, -0.008927666582167149, -0.03477741777896881, 0.0037176557816565037, 0.011727450415492058, -0.01545229647308588, -0.011892206966876984, 0.0016349523793905973, -0.007755766622722149, 0.03413080796599388, 0.001160954125225544, 0.011203430593013763, 0.018427859991788864, -0.01174582913517952, 0.0004951423034071922, 0.012530580163002014, -0.025062404572963715, 0.010618280619382858, 0.01762227900326252, 0.025116026401519775, 0.001405511051416397, -0.01320011168718338, -0.008960256353020668, -0.010033488273620605, -0.01319504901766777, -0.016528140753507614, 0.015452858060598373, 0.0051933638751506805, 0.016400756314396858, 0.03376711159944534, -0.014645526185631752, -0.009702766314148903, -0.004424103535711765, -0.018380172550678253, -0.013811214827001095, -0.005435870494693518, 0.00045189959928393364, 0.00619935616850853, 0.021696787327528, 0.019945818930864334, -0.0030007422901690006, -0.004664131440222263, 0.01913774386048317, -0.0011089021572843194, 0.0025875817518681288, 0.022230640053749084, 0.009211753495037556, 0.002421388868242502, 0.024386374279856682, -0.0059191458858549595 ]
[ -0.04325903579592705, -0.23008127510547638, 0.07674732804298401, 0.1584915816783905, -0.594478964805603, -0.12261707335710526, 0.14254623651504517, -0.10249490290880203, 0.07105336338281631, -0.7188277244567871, -0.02971058525145054, -0.8009707927703857, -0.5564202070236206, 0.3363625705242157, 0.10993624478578568, 0.7385178208351135, 0.31572645902633667, 0.4558056592941284, -0.07892908900976181, -0.6395251750946045, -0.19124677777290344, -0.1566346138715744, 0.6056514978408813, -0.279123991727829, 0.26807665824890137, 0.3455309271812439, 0.11988481879234314, -0.10515812784433365, 0.6036670804023743, -0.2715553641319275, -0.024307282641530037, 0.06290822476148605, -0.06124257296323776, -0.20173561573028564, -0.2408841997385025, 0.1632433980703354, -0.5419906377792358, 0.16770750284194946, 0.1838379055261612, -0.18839402496814728, -0.2839778959751129, -0.9359014630317688, 0.18022611737251282, 0.2731061577796936, -0.006307859439402819, -0.5442345142364502, -0.597104549407959, 0.9651317596435547, -0.8953836560249329, -0.04826488345861435, -0.03784956783056259, 0.2886601984500885, 0.3082534968852997, 0.22273631393909454, 0.06643983721733093, -0.20531360805034637, -0.4445808231830597, 0.14994993805885315, 0.3930884003639221, -0.8863134980201721, -0.19684238731861115, 0.33188626170158386, -0.15859362483024597, 0.12997747957706451, 0.20148353278636932, 0.6292659044265747, 0.10300593823194504, -0.07901827991008759, -0.253269761800766, -0.2605491578578949, 0.3226476013660431, -0.42070135474205017, -0.050738248974084854, 0.5422706604003906, 0.15575167536735535, -0.30434995889663696, -0.3109111785888672, 0.012838124297559261, -0.408592164516449, 0.2835645377635956, -0.26298731565475464, 0.4557563066482544, -0.13900816440582275, 0.30834850668907166, 0.48596620559692383, 0.3676088750362396, -0.3819606602191925, 0.4468330144882202, -0.8934789896011353, 0.3084961473941803, -0.05282701179385185, 0.04216558486223221, 0.4673241376876831, 0.12923531234264374, 0.28648462891578674, 0.25393372774124146, -0.41224008798599243, -0.1023879423737526, 0.4675949513912201, -0.005155363120138645, -0.5635969042778015, -0.12290079891681671, 0.28955671191215515, -0.6212706565856934, 0.29094672203063965, 0.036153219640254974, -0.2654425799846649, -0.5226717591285706, -0.6606028079986572, -0.263113409280777, -0.03346351534128189, 0.012558508664369583, -0.29418686032295227, 0.22792337834835052, 0.1193123608827591, 0.5245164036750793, 0.34058231115341187, -0.9544394612312317, 0.2853994071483612, 0.012550910003483295, -0.5039472579956055, 1.5028882026672363, -0.28005847334861755, 0.13111349940299988, -0.09255845844745636, -0.40694501996040344, 0.6684691905975342, 0.1324886679649353, -0.25895529985427856, 1.2262821197509766, 0.2868625521659851, 0.833736002445221, -0.21355457603931427, 0.20144341886043549, 0.020293360576033592, -0.281002014875412, -0.30094724893569946, 0.3657529354095459, -0.17275679111480713, -0.03190796822309494, -0.7777296304702759, 0.06659531593322754, 0.06205255165696144, -0.08899432420730591, 0.2514428496360779, 0.09706427901983261, -0.2547065317630768, 0.03961445763707161, -0.5184741616249084, -0.3696010112762451, -0.05989080294966698, -0.5970731973648071, -0.1827242374420166, 0.0980018898844719, -0.10401670634746552, 0.1535293459892273, 0.41744494438171387, 0.21498611569404602, -0.18993884325027466, 0.5416483283042908, 0.4822525680065155, -0.2925238311290741, -0.3165406584739685, 0.06429534405469894, 0.29250356554985046, 0.21357989311218262, 0.19037260115146637, 0.6094492673873901, 0.2781185805797577, 0.0017240450251847506, 0.5114139318466187, -0.8603443503379822, -0.33433160185813904, -0.9870663285255432, -0.3599107563495636, -0.2806403636932373, -0.07040197402238846, -0.24773864448070526, 0.26779791712760925, 0.11036128550767899, -0.7495286464691162, -0.15290330350399017, -0.19110345840454102, 0.055317170917987823, 0.07329311966896057, 0.30811572074890137, 0.926705002784729, 0.3139411509037018, -0.3465960919857025, 0.27148234844207764, -0.5313388705253601, 0.0279677826911211, 0.21519173681735992, -0.452026903629303, 1.384889841079712, 0.22180822491645813, -0.5269894003868103, 1.6275988817214966, 0.5471574664115906, -0.029840568080544472, -0.6206780672073364, 0.4018694758415222, 0.6718541383743286, -0.8935865163803101, -0.5385341048240662, 0.484404057264328, 0.5045274496078491, 0.18347960710525513, -0.12545371055603027, -0.6104917526245117, 0.10261547565460205, -0.6209304332733154, 0.014981565997004509, 0.17543086409568787, 0.024871159344911575, -0.48074251413345337, 0.10681243240833282, -0.5544794201850891, 0.42650166153907776, -0.07688149809837341, 0.5365166664123535, -0.8042899370193481, 1.0007027387619019, 0.42316925525665283, -0.5366374254226685, 0.7419235110282898, 0.6074562668800354, 0.22807219624519348, 0.6680182218551636, 0.3420061767101288, 0.6364876627922058, -0.7189716100692749, 0.48287802934646606, -0.4308132827281952, -0.0860225036740303, -0.14895182847976685, 0.024537349119782448, -0.24809634685516357, 0.20626020431518555, 0.3070615530014038, 0.09270437061786652, 0.9942193031311035, -0.44426655769348145, -0.45103922486305237, -0.06751588732004166, -0.638014018535614, -0.10108722001314163, 0.056992657482624054, -0.2673283815383911, -0.011191539466381073, -0.022737059742212296, 0.33152660727500916, -0.07429873198270798, -0.631070077419281, 0.42485952377319336, 0.4549756348133087, -0.36958467960357666, -0.031138727441430092, 0.12157555669546127, -0.6710323691368103, -0.7935707569122314, -0.1576048880815506, 0.06330718845129013, 0.37591156363487244, 0.18089216947555542, -0.7099015116691589, -0.5791944265365601, -0.18490026891231537, 1.0970149040222168, 0.7174832820892334, 0.9328316450119019, -0.11730245500802994, -0.4270086884498596, -0.20396578311920166, 0.11788498610258102, -0.5672338604927063, 0.22647948563098907, 0.5659478902816772, -0.3821294903755188, -0.8698790669441223, 0.24078361690044403, 0.44132199883461, 0.6760473847389221, -0.3966814875602722, -0.21356435120105743, -0.5162484645843506, 0.13044525682926178, 0.2726292908191681, -0.7985391616821289, -0.6437032222747803, 0.22549492120742798, 0.6036290526390076, -0.33799830079078674, 0.3750113546848297, 0.29599887132644653, 0.35178661346435547, 0.307468980550766, 0.2869051396846771, 0.8451478481292725, -0.12977473437786102, -0.5167295932769775, -0.2025279700756073, -0.4966038465499878, -0.14718645811080933, 0.36734434962272644, 0.24144963920116425, -0.11114431917667389, -0.22085882723331451, -5.470766544342041, -0.019471392035484314, -0.09792409837245941, 0.01391731109470129, 0.26454243063926697, -0.1552201509475708, 1.0096920728683472, -0.33703500032424927, 0.33247801661491394, 0.33055147528648376, 0.27433744072914124, 0.46349573135375977, 0.1251349002122879, -0.15961186587810516, 0.05391151085495949, 0.5756455659866333, 0.13530023396015167, -0.31059396266937256, 0.7020359635353088, -0.0818621814250946, -0.21736808121204376, -0.22249898314476013, -0.04702593758702278, 0.15886586904525757, -0.020355399698019028, -0.05845949426293373, -0.9105160236358643, 0.2785463035106659, -0.02647996135056019, -0.39633744955062866, 0.9098868370056152, -0.8696290850639343, -0.07989222556352615, -0.412493497133255, -0.31185096502304077, -0.45750439167022705, 0.445533812046051, -0.15778738260269165, -0.40816742181777954, -0.16092754900455475, 0.7298025488853455, 0.18163402378559113, 0.22812756896018982, -0.3048474192619324, 0.15365464985370636, 0.05754798650741577, -0.21009449660778046, -0.003184816800057888, 0.33961138129234314, 0.5581372380256653, 0.1541227400302887, -0.14101770520210266, 0.20755058526992798, 0.1457895189523697, 0.27466556429862976, -0.06900091469287872, 0.0015075962292030454, 0.2487318515777588, -0.8038723468780518, -0.09655661135911942, -0.10730231553316116, -0.12313151359558105, -0.36914560198783875, -0.889221727848053, 0.0750630721449852, 0.6206099390983582, -0.8378178477287292, 0.3200996220111847, 0.16959300637245178, -0.06779343634843826, 0.05132446065545082, 0.20613735914230347, -0.08245652914047241, -0.4683630168437958, 0.6377207636833191, -0.676528811454773, 0.5767837166786194, -0.1551809012889862, -0.5155206322669983, 0.11401486396789551, -0.45301297307014465, -0.41413193941116333, -0.23706191778182983, -0.30914556980133057, 1.0895216464996338, 0.008929295465350151, -0.08124867081642151, -0.09226786345243454, -0.4358644187450409, 0.19481177628040314, 0.28407397866249084, -0.05192932114005089, 0.26794925332069397, 0.9144576191902161, 0.18205790221691132, 0.418696790933609, 0.04947897046804428, 0.888168215751648, 0.49185243248939514, 0.0762115940451622, 0.8666200041770935, 0.03848135471343994, -0.36587345600128174, -0.8214864730834961, -0.24108919501304626, 0.3608768880367279, -0.49291884899139404, 0.03560589626431465, 0.44998541474342346, -0.3441900610923767, 0.2809741795063019, -0.014747590757906437, -0.5420883297920227, 0.4348142147064209, 0.9243360161781311, 0.1618439257144928, -0.50578773021698, 0.023472696542739868, 0.3524051308631897, -0.3519875705242157, 0.5086492896080017, 0.2826023995876312, -0.6971324682235718, 0.4478285312652588, -0.6725886464118958, -0.5248345136642456, -0.09452874958515167, 0.939993143081665, -0.4428994655609131, -0.308737576007843, 0.30949580669403076, 0.2602170705795288, -0.645801305770874, -0.24333913624286652, 0.27849188446998596, -0.3170005977153778, -0.5255331993103027, 0.45958027243614197, 0.49174177646636963, -0.052842188626527786, 0.13841360807418823, -0.5055524110794067, 0.03827516734600067, 0.22484396398067474, 0.06432094424962997, 0.1630328893661499, 0.03539435565471649, 0.15436449646949768, -0.5444565415382385, -0.25058093667030334, -0.20296868681907654, -0.3533828556537628, 0.01608189381659031, 0.030537232756614685, -0.011270016431808472, 0.08093579113483429, 0.7899103760719299, 0.1112794280052185, 0.6801283359527588, -0.2740165591239929, -0.030864201486110687, 0.10934043675661087, -0.7903425097465515, 0.35983943939208984, -0.6815587878227234, -0.26120197772979736, 0.16832807660102844, -0.43522965908050537, -0.5550543069839478, 0.01195377018302679, -0.4476103186607361, -0.09746330976486206, 0.742492139339447, -0.14000363647937775, 0.02575930953025818, -0.11756496876478195, -0.08207091689109802, -0.1674281805753708, -0.11114323139190674, -0.0026823158841580153, -0.5329335927963257, 0.011188618838787079, -0.2595403492450714, 0.41127610206604004, 0.11990568041801453, 0.12998518347740173, -0.3379606008529663, 0.18018309772014618, -0.5929862260818481, -0.6007511615753174, 0.21094989776611328, 0.01095002144575119, 0.22159211337566376, -0.13715793192386627, -0.30005884170532227, 0.08547024428844452, 0.15467481315135956, 0.529823899269104, -0.4908285439014435, -0.7938636541366577, 0.018173906952142715, 0.05066784843802452, -0.2721232771873474, 0.34473899006843567, 0.10268693417310715, 0.030853496864438057, -0.39290663599967957, 0.20664948225021362, -0.32185062766075134, -0.6124576926231384, -0.17512246966362, -0.44831323623657227, 0.5506461262702942, 0.3831658959388733, -0.5722313523292542, 0.10153519362211227, 0.27179157733917236, -0.03805457055568695, 0.25843748450279236, 0.06644126772880554, 0.23419751226902008, 0.07017777115106583, 0.5404012799263, -0.4288060665130615, -0.36008235812187195, 0.6622558832168579, 0.5803963541984558, -1.0599169731140137, -0.05428353697061539, -0.19802328944206238, 0.23673240840435028, -1.0085539817810059, 0.13381610810756683, -0.0630488470196724, -0.5586851239204407, -0.37243032455444336, -0.9022783637046814, -0.2410568743944168, -0.11054030060768127, 0.6128252148628235, 0.18838143348693848, -0.06374777108430862, -0.27385157346725464, -0.27774208784103394, -0.5182530283927917, 0.05694834515452385, 0.508445680141449, -0.4847322702407837, -0.18759599328041077, 0.3999538719654083, -0.07186125963926315, -0.2718941271305084, -0.0331561304628849, 0.6550636291503906, 1.5321861505508423, 0.36562880873680115, -0.16616728901863098, -0.7252164483070374, -0.5503015518188477, -0.11373896151781082, -0.18629808723926544, 0.3164576590061188, -0.44731083512306213, 0.48199930787086487, -0.3127498924732208, -0.22773876786231995, 0.2629055380821228, -0.6428363919258118, 0.46155622601509094, 0.22966016829013824, -0.2700219452381134, -0.013022390194237232, 0.04986479505896568, 0.6648534536361694, -0.6175236701965332, 0.039811860769987106, 0.07921186834573746, 0.6951684355735779, 0.12733380496501923, 0.5415888428688049, -0.6172112822532654, -0.6406922936439514, 0.525715172290802, -0.5709966421127319, -0.3371783196926117, -0.535290002822876, 0.39978963136672974, -0.38762518763542175, 0.0515933483839035, 0.2632347047328949, -0.383677214384079, -0.0947847068309784, -0.7786061763763428, -0.6936224102973938, -0.050799354910850525, -0.00897340476512909, -0.04729229211807251, -0.025396021082997322, -0.37388479709625244, 0.1355862021446228, -0.7763245105743408, 0.2721875011920929, 0.3416857123374939, -0.4086342751979828, -0.2926579713821411, 0.01571720279753208, 0.43450769782066345, 0.2613014876842499, -0.4280592203140259, -0.3464611768722534, 0.04843299463391304, 0.09169832617044449, 0.4172954857349396, -0.16368378698825836, -0.7238876819610596, 0.1587998867034912, 0.03498728945851326, 0.35972627997398376, -0.18909801542758942, 0.2854437530040741, 0.2816767990589142, 0.3262350261211395, 0.7755833268165588, 0.143416166305542, -0.5412095189094543, 0.49349474906921387, 0.20216763019561768, -0.3894737958908081, -0.4810532331466675, 0.6668395400047302, 0.5167780518531799, -0.32115858793258667, -0.15621545910835266, 0.42386841773986816, 0.42936694622039795, 0.4113360047340393, -0.5016016960144043, -0.16693483293056488, -0.0803961530327797, -0.17800772190093994, 0.1730092614889145, 0.6084944009780884, -0.2571655213832855, -0.06737489998340607, 0.3594929873943329, -0.12590062618255615, -0.00045257798046804965, -0.15461276471614838, 0.27715301513671875, 0.23544733226299286, 0.5112670660018921, -0.14120744168758392, -0.3118378520011902, 0.3039532005786896, -0.45811501145362854, -0.16627119481563568, 0.5607137680053711, -0.1021905317902565, -0.6959879398345947, 0.19551797211170197, -0.09854945540428162, 0.3683280348777771, 0.1315726488828659, 0.8802192807197571, -0.7406327128410339, -0.7125239968299866, 0.32161960005760193, 0.4889954924583435, 0.0016634841449558735, -0.20852845907211304, 0.24118253588676453, 0.1874222457408905, -0.3074033558368683, 0.8847798705101013, 0.2284860759973526, 0.03026341088116169, 0.08571206778287888, 0.2623975872993469, 0.29755914211273193, -0.11589588969945908, 0.26851099729537964, 0.023626334965229034, -0.26148998737335205, -1.0255279541015625, -0.069115549325943, -0.4912700653076172, 0.0879979133605957, 0.03500679135322571, -0.052108410745859146, 0.16151006519794464, 0.2527848184108734, -0.7296752333641052, -0.006251204293221235, 0.00009006618347484618, -0.07155495136976242, -0.008139953948557377, -0.09662425518035889, 0.5993651151657104, 0.4194581210613251, 0.5211236476898193, 0.2052692025899887, 0.3183727562427521, 0.1519341766834259, 0.5772719979286194, -0.438463419675827, 0.9848352670669556, -0.3722204566001892, 0.129313662648201, -0.385153591632843, -0.07982854545116425, 1.3310710191726685, 0.9158818125724792, -0.2985326945781708, 0.1661548763513565, 0.0025390300434082747, 0.15089212357997894, 0.26011526584625244, -0.4842178523540497, 0.17327003180980682, -0.03704812750220299, -0.08803340047597885, -0.4396359622478485, 0.5531668663024902, 0.22777508199214935, -0.49869200587272644, 0.23861844837665558, 0.09578868746757507, 0.5769286155700684, -0.25939810276031494, 0.593116044998169, 0.09122946113348007, 0.3174709975719452, 0.0032092947512865067, 0.4620939791202545, -0.07784302532672882, 0.3595035672187805, -0.9339370131492615, -0.00563829904422164, -0.2382308840751648, -0.37669962644577026, 0.010450758039951324, -0.11688439548015594, -0.14896437525749207, -0.6886270046234131, 0.047301072627305984, 0.13642826676368713, -0.23242686688899994, -0.7251750826835632, -1.1406984329223633, 0.2390306293964386, 0.07694467902183533, -0.3124638497829437, -0.1205725148320198, 0.07516323029994965, -0.332460880279541, -0.06622727960348129, -0.04540472477674484, 0.012086170725524426, -0.1895045042037964, 0.05296950414776802 ]
Primary cilia are microtubule-based sensory organelles that coordinate signalling pathways in cell-cycle control, migration, differentiation and other cellular processes critical during development and for tissue homeostasis. Accordingly, defects in assembly or function of primary cilia lead to a plethora of developmental disorders and pathological conditions now known as ciliopathies. In this review, we summarize the current status of the role of primary cilia in coordinating receptor tyrosine kinase (RTK) signalling pathways. Further, we present potential mechanisms of signalling crosstalk and networking in the primary cilium and discuss how defects in ciliary RTK signalling are linked to human diseases and disorders.
[ 0.0021930979564785957, 0.001998504623770714, -0.010407685302197933, 0.013331398367881775, 0.004836104344576597, -0.02241450548171997, 0.011469079181551933, 0.007479090243577957, -0.008935319259762764, 0.01594861038029194, -0.021919680759310722, 0.0001788067165762186, -0.011421067640185356, 0.025984395295381546, -0.029336195439100266, -0.022678960114717484, -0.013439514674246311, 0.025004662573337555, 0.008194787427783012, 0.004202215000987053, -0.008405284956097603, -0.017920471727848053, 0.010329004377126694, 0.0074874586425721645, 0.03318857029080391, -0.012810535728931427, -0.021962322294712067, -0.018014337867498398, -0.034257322549819946, 0.018697084859013557, 0.006646482273936272, -0.018671143800020218, 0.019042545929551125, 0.021663006395101547, 0.0003096784930676222, -0.04349299892783165, -0.007567812688648701, 0.022287961095571518, -0.004867074079811573, -0.0033371183089911938, 0.006497167982161045, -0.0025832424871623516, 0.006105523090809584, -0.0008458246011286974, -0.007081742864102125, 0.010584861040115356, 0.003078881651163101, -0.003284469014033675, 0.007075927220284939, 0.004620234481990337, -0.007959920912981033, -0.011616544798016548, 0.005804336629807949, 0.03135870024561882, -0.006001534406095743, -0.00010283396113663912, 0.01778569631278515, -0.033211782574653625, -0.014916975982487202, -0.00006318697705864906, -0.014839719980955124, 0.00663504796102643, 0.005712881218641996, -0.02944011613726616, 0.0035507010761648417, -0.06674520671367645, -0.022144481539726257, -0.005413960199803114, -0.011990129016339779, -0.01009133830666542, -0.014715764671564102, 0.0015904611209407449, -0.02964720129966736, -0.024460498243570328, 0.03042818233370781, -0.033435311168432236, -0.025030728429555893, -0.005261065438389778, -0.01288425363600254, 0.01584106683731079, 0.0037002586759626865, -0.01612454652786255, 0.00533657893538475, 0.008858895860612392, -0.0035251714289188385, 0.007038451265543699, -0.013240847736597061, 0.016784818843007088, -0.016067136079072952, -0.03902537748217583, 0.013119282200932503, -0.010807100683450699, 0.012149735353887081, -0.009896253235638142, 0.008932081051170826, 0.00871017575263977, -0.04305750131607056, 0.03652752935886383, -0.007863739505410194, -0.017369039356708527, -0.027246620506048203, 0.010541422292590141, 0.013276223093271255, 0.007281676400452852, -0.007462138310074806, 0.014827251434326172, -0.01259277481585741, -0.004480014555156231, -0.021253224462270737, 0.014422153122723103, -0.016741005703806877, 0.016509082168340683, 0.002347100991755724, -0.026638735085725784, 0.03392940014600754, -0.020807627588510513, 0.002949333284050226, -0.0049394769594073296, 0.0076279593631625175, 0.015010090544819832, 0.01564343087375164, -0.01867777109146118, 0.0016523906961083412, 0.039999451488256454, 0.01117206271737814, -0.0020163021981716156, 0.018265482038259506, 0.01892365701496601, 0.001033729175105691, 0.00041709840297698975, -0.010652485303580761, 0.016720404848456383, 0.010151575319468975, -0.009703096933662891, -0.006406460888683796, -0.006430638022720814, -0.015735259279608727, -0.026628917083144188, -0.011147990822792053, -0.023263053968548775, 0.002967163920402527, 0.011556824669241905, 0.003003097604960203, 0.004552190192043781, 0.031984928995370865, 0.007524813525378704, -0.010648664087057114, 0.006188856903463602, -0.020343508571386337, -0.007069073151797056, 0.019540369510650635, 0.005511697381734848, -0.008693104609847069, -0.023646261543035507, -0.005809669382870197, -0.009641723707318306, -0.026755735278129578, -0.024869441986083984, 0.015239600092172623, 0.0007157947402447462, 0.012813843786716461, 0.010700657963752747, -0.008105307817459106, 0.01003286987543106, -0.009254466742277145, 0.004783728159964085, 0.002161219948902726, -0.001150284893810749, 0.017269056290388107, 0.00843124557286501, -0.021403498947620392, 0.01886822283267975, -0.03827466070652008, 0.015800105407834053, 0.003985257353633642, 0.006571559235453606, -0.007469055708497763, 0.008899637497961521, -0.008951994590461254, 0.06672637909650803, -0.014341761358082294, -0.006879244931042194, 0.013402508571743965, -0.03225214034318924, 0.0026510769966989756, -0.008261311799287796, 0.0030184080824255943, -0.016217898577451706, 0.006600045599043369, 0.007154990918934345, -0.0009864019230008125, -0.003163142129778862, -0.01265184860676527, 0.01370210014283657, -0.04090883582830429, 0.003252740018069744, 0.008651066571474075, 0.00915142148733139, -0.0028276657685637474, 0.027508597820997238, -0.012758128345012665, -0.015417144633829594, 0.03285931795835495, 0.007760421372950077, 0.016882983967661858, -0.0156620591878891, -0.022459233179688454, -0.02290349267423153, -0.04740942269563675, 0.0003378060646355152, 0.00264865648932755, -0.022208716720342636, -0.031417787075042725, 0.010356685146689415, 0.010082097724080086, -0.00526498444378376, -0.0267019085586071, -0.020367972552776337, -0.039448872208595276, -0.016780588775873184, -0.0013079112395644188, 0.024613790214061737, 0.029935497790575027, 0.012614155188202858, -0.021489763632416725, -0.003893542103469372, -0.0026433926541358232, 0.014172300696372986, 0.004741784185171127, 0.010101474821567535, -0.0032267409842461348, -0.002642026636749506, -0.012075131759047508, 0.00905322190374136, 0.04702891781926155, 0.011874739080667496, 0.013124477118253708, -0.010561700910329819, 0.013152685016393661, -0.003748355433344841, 0.007341722957789898, -0.0031896899454295635, 0.060445114970207214, -0.0010780896991491318, -0.008139768615365028, 0.010615704581141472, -0.005941051058471203, -0.0032582348212599754, 0.02123728208243847, -0.012957068160176277, 0.0029619140550494194, -0.0008207636419683695, -0.02024836651980877, 0.03763642534613609, 0.012820770032703876, 0.021950416266918182, 0.0005216547288000584, 0.0017892734613269567, 0.022675078362226486, -0.024857783690094948, 0.002072928473353386, 0.004474742338061333, 0.012560444884002209, 0.001603820943273604, 0.01686951518058777, -0.02550634928047657, -0.0010847061639651656, 0.021925628185272217, -0.024427222087979317, 0.0011536972597241402, 0.010116826742887497, -0.004206616431474686, 0.00591717753559351, -0.08060705661773682, -0.013529867865145206, -0.006809137761592865, -0.008902360685169697, 0.013579295016825199, -0.0015707933343946934, -0.011545458808541298, -0.00947931595146656, 0.0058309659361839294, 0.026679977774620056, 0.009354546666145325, 0.0008526323363184929, -0.008209229446947575, -0.001899605500511825, 0.02494426816701889, -0.0055685401894152164, 0.012894107028841972, -0.029154116287827492, -0.0032346006482839584, -0.014581851661205292, -0.0016166376881301403, -0.014469939284026623, -0.02092624083161354, 0.01021958701312542, -0.02112351916730404, 0.008574704639613628, 0.0021095573902130127, 0.003828634973615408, 0.021236054599285126, -0.0022486106026917696, -0.014883354306221008, 0.013327933847904205, 0.023262685164809227, -0.0030006251763552427, 0.027149274945259094, 0.015512537211179733, 0.03344173729419708, 0.0015161127084866166, -0.019235683605074883, 0.02359522134065628, -0.0081368712708354, 0.01987147517502308, -0.004844124428927898, 0.0062784356996417046, -0.0010557319037616253, 0.009238718077540398, 0.01142569724470377, -0.0027716043405234814, 0.015321262180805206, -0.013436353765428066, -0.003170078620314598, -0.003300989745184779, 0.015784403309226036, 0.014217881485819817, -0.014598468318581581, 0.001865986967459321, -0.019756902009248734, 0.009038561955094337, -0.01395406574010849, -0.014947794377803802, -0.00766371563076973, -0.021545272320508957, -0.016383595764636993, 0.004567387513816357, -0.0010773329995572567, -0.03132812678813934, 0.023845668882131577, -0.008468535728752613, -0.019159510731697083, 0.018203575164079666, 0.018508804962038994, -0.02285822108387947, -0.014625072479248047, -0.012782890349626541, -0.00786374881863594, -0.009381400421261787, -0.0046866415068507195, -0.002970021218061447, -0.005333291366696358, -0.0432460643351078, -0.002449250780045986, 0.00658137071877718, -0.01877070963382721, -0.0018382101552560925, -0.013104450888931751, -0.014094777405261993, 0.007505337707698345, 0.05782966688275337, -0.0018805782310664654, -0.020091034471988678, 0.018270395696163177, 0.010125495493412018, -0.019674232229590416, 0.008843997493386269, -0.0065742419101297855, 0.002114926464855671, -0.019451308995485306, -0.003544083796441555, -0.004260007292032242, 0.007993293926119804, -0.01043365802615881, 0.006626760121434927, -0.028708672150969505, -0.009933680295944214, -0.006109131500124931, 0.01682189851999283, 0.009000233374536037, -0.026003293693065643, 0.011010350659489632, 0.0024792442563921213, 0.02545040473341942, 0.04117530584335327, -0.013138171285390854, 0.016710640862584114, 0.017732728272676468, -0.001396536361426115, -0.02599531039595604, -0.009934762492775917, 0.07213109731674194, 0.0017181569710373878, -0.01230204664170742, -0.007932284846901894, 0.003118184395134449, -0.008101291954517365, -0.021210063248872757, 0.005667722783982754, -0.006280591711401939, 0.02359304018318653, 0.010716399177908897, -0.01564686745405197, -0.023626837879419327, 0.012425145134329796, -0.01912490278482437, -0.020597118884325027, -0.033012520521879196, -0.002953396877273917, -0.016085674986243248, 0.02488381415605545, 0.028674321249127388, -0.015273974277079105, -0.007695628330111504, -0.004573027603328228, -0.00735221803188324, -0.026394998654723167, 0.0021710293367505074, -0.013261358253657818, -0.015889346599578857, 0.008369951508939266, 0.003377548884600401, 0.018067695200443268, -0.004908457864075899, 0.019770648330450058, -0.015211543999612331, -0.008222171105444431, 0.02480393648147583, -0.038096699863672256, -0.0018829831387847662, -0.004855389706790447, 0.003028496401384473, -0.008522948250174522, 0.030749324709177017, 0.009997810237109661, 0.017177965492010117, -0.02698289230465889, -0.012753690592944622, -0.009573298506438732, -0.010896879248321056, -0.005716408137232065, -0.008700165897607803, 0.004108825698494911, 0.011996809393167496, 0.011311570182442665, 0.0019099335186183453, -0.009662823751568794, 0.02842594124376774, -0.003085205564275384, -0.0045860144309699535, -0.012779216282069683, -0.010232212953269482, 0.009566430002450943, 0.04214567318558693, -0.02085462585091591, -0.0004698685370385647, -0.01741630770266056, 0.021378492936491966, 0.0013838019222021103, -0.011590971611440182, -0.019257156178355217, -0.017738331109285355, -0.008353341370821, 0.0005860012024641037, 0.02282380871474743, -0.008554315194487572, -0.028359392657876015, 0.030148928984999657, -0.030359720811247826, 0.010983113199472427, -0.019823173061013222, -0.014933710917830467, 0.009757927618920803, 0.03506818413734436, 0.012180241756141186, -0.01966332644224167, -0.04233629256486893, -0.014407912269234657, -0.07413531094789505, -0.008120494894683361, 0.015680760145187378, -0.0045823948457837105, 0.022286370396614075, 0.001872367225587368, -0.005599427968263626, -0.003035268746316433, 0.015205048024654388, -0.009056400507688522, -0.010140161961317062, 0.014376090839505196, 0.009548377245664597, 0.001326387282460928, 0.010769094340503216, 0.029495414346456528, -0.004031417891383171, 0.008977926336228848, -0.012382667511701584, -0.014875028282403946, 0.03693950176239014, 0.021133482456207275, -0.02194465696811676, 0.013517854735255241, 0.006398865021765232, -0.08084253966808319, -0.010710509493947029, 0.0127315204590559, 0.01529962383210659, 0.005678641144186258, 0.02515135332942009, -0.018258817493915558, -0.00455939956009388, -0.04913021996617317, -0.01814291626214981, 0.03260311111807823, -0.0016634343191981316, -0.03539508208632469, -0.00912743341177702, -0.021932708099484444, -0.005284582730382681, 0.02944764867424965, -0.021009692922234535, 0.03160471469163895, 0.018355373293161392, -0.0026107877492904663, 0.008016690611839294, -0.014020581729710102, 0.008989576250314713, -0.009080532938241959, -0.022495998069643974, -0.009586463682353497, 0.018488097935914993, -0.00572427362203598, -0.009097266010940075, -0.010798017494380474, 0.000027432601200416684, -0.005626775324344635, 0.011053858324885368, 0.004567934200167656, -0.0206762608140707, 0.030072426423430443, 0.01568063348531723, -0.006464590784162283, -0.014556126669049263, -0.0033039909321814775, -0.0022392927203327417, -0.019063621759414673, 0.014428650960326195, 0.009119447320699692, 0.0018686926923692226, 0.0036620881874114275, 0.0018915706314146519, 0.0022700452245771885, 0.0142446868121624, 0.02133280783891678, 0.016975797712802887, 0.008420536294579506, -0.02246098779141903, 0.019112002104520798, 0.009520760737359524, -0.0075107961893081665, 0.015445830300450325, 0.0010534472530707717, 0.00511603057384491, -0.006356422323733568, 0.006609275937080383, 0.010592884384095669, 0.07188380509614944, -0.00861899834126234, -0.011372005566954613, 0.006728805601596832, 0.008863994851708412, 0.0025466452352702618, -0.00939760822802782, -0.02775227651000023, 0.03070390596985817, -0.040206730365753174, -0.020679207518696785, -0.007322949822992086, -0.0188552588224411, 0.01221437193453312, 0.02509613335132599, -0.0009417624678462744, -0.03773965686559677, -0.001130918855778873, -0.01802033744752407, -0.002162845339626074, -0.027135390788316727, -0.008663555607199669, -0.02501027099788189, 0.009296568110585213, 0.01121039129793644, -0.003289992455393076, 0.00016096746549010277, 0.018358254805207253, -0.007056446745991707, -0.0391061007976532, -0.02481747977435589, -0.04141303151845932, -0.0002915330696851015, 0.014373083598911762, 0.023238297551870346, 0.01627221703529358, 0.014799240045249462, 0.003573950380086899, -0.02210090681910515, -0.02465859428048134, -0.0013047633692622185, -0.0071462104097008705, -0.0005829045549035072, 0.009416744112968445, -0.01385587640106678, -0.012591412290930748, 0.006429607048630714, 0.009079702198505402, 0.022612111642956734, 0.020189695060253143, -0.03844643384218216, -0.006957654375582933, 0.023209717124700546, -0.026267604902386665, -0.0030889054760336876, 0.03408557176589966, -0.015053791925311089, 0.009033963084220886, -0.025111360475420952, -0.009055839851498604, -0.0020011356100440025, -0.004471692256629467, 0.016763828694820404, -0.004568553529679775, 0.0000935832504183054, 0.00812616664916277, 0.00702136754989624, -0.0074308449402451515, -0.0019431652035564184, 0.016422193497419357, -0.004893438890576363, 0.020283598452806473, 0.006888811942189932, 0.016667433083057404, 0.005298316478729248, 0.01958707720041275, -0.006585981696844101, -0.0261826254427433, 0.01972760073840618, 0.001327240839600563, -0.013213531114161015, -0.0007754475809633732, 0.003826491069048643, -0.005672900937497616, -0.03230752795934677, 0.023936357349157333, -0.009710544720292091, 0.039701420813798904, -0.005924167577177286, 0.011908196844160557, -0.01833254098892212, 0.005614406429231167, 0.005271725356578827, 0.005203870125114918, 0.007167664356529713, 0.0325605645775795, 0.0029832355212420225, -0.0006267072167247534, 0.015951449051499367, 0.018037104979157448, 0.01386278122663498, 0.005415647756308317, -0.005668811500072479, -0.010306039825081825, -0.023604273796081543, -0.009455750696361065, 0.006099612917751074, -0.011941279284656048, -0.0025203002151101828, -0.008237955160439014, -0.033757567405700684, 0.024975717067718506, -0.00830270629376173, 0.00834619253873825, 0.010843533091247082, -0.014920847490429878, -0.026545461267232895, -0.012674050405621529, -0.00625544972717762, -0.00695663271471858, 0.013978365808725357, -0.002200604183599353, -0.002869977615773678, 0.012996148318052292, -0.007980585098266602, -0.01971489004790783, -0.008003158494830132, 0.03408977389335632, 0.010371343232691288, -0.05123581737279892, 0.0023348622489720583, -0.02392575889825821, -0.02242075651884079, -0.01762649044394493, -0.007146009244024754, 0.03876481205224991, -0.006340311840176582, -0.005423429887741804, -0.006972180213779211, 0.007840728387236595, -0.010470125824213028, -0.03043532185256481, -0.008265919983386993, 0.02472732961177826, 0.00838022492825985, -0.011327223852276802, 0.007715723942965269, 0.011423910036683083, 0.00996447168290615, -0.007554367650300264, -0.008007093332707882, 0.009738005697727203, -0.03275293856859207, -0.013330242596566677, -0.022732309997081757, 0.01867755502462387, 0.012971115298569202, 0.009334057569503784, -0.028834424912929535, -0.021155137568712234, -0.009217644110321999, 0.014055171050131321, -0.0022083623334765434, -0.009474001824855804, 0.02761884592473507, -0.0037144627422094345, -0.02342064678668976, 0.006048271432518959, 0.01685151644051075, 0.004148322157561779, -0.0007214024662971497, -0.022131744772195816, -0.01150310318917036, 0.021130770444869995, -0.007979422807693481, -0.007134598214179277, 0.00469529815018177, -0.015202166512608528, 0.035600319504737854, -0.015215939842164516, -0.028442708775401115, -0.03197198361158371, 0.013765828683972359, -0.00907318014651537, -0.005314867943525314, -0.02219412475824356, -0.012307221069931984, -0.02041097916662693, 0.0025637978687882423, 0.002400587312877178, -0.005502454936504364, 0.011381748132407665, -0.007025883067399263, 0.016303546726703644, -0.006474300287663937, -0.004459102638065815, 0.025778882205486298, -0.06176268681883812, 0.0006093633710406721, -0.024993354454636574, -0.009693965315818787, -0.01156550832092762 ]
[ 0.39102256298065186, -0.29433807730674744, 0.11617785692214966, 0.3428216576576233, 0.3622526526451111, 0.05829216539859772, -0.03164387866854668, 0.3758247196674347, -0.38808345794677734, -0.5446677207946777, -0.11952469497919083, 0.11005416512489319, -0.6749975085258484, 0.42017242312431335, -0.283060759305954, 0.2669927775859833, 0.3946423828601837, 0.38019636273384094, -0.20734314620494843, -0.11472111940383911, -0.4911400079727173, -0.010141673497855663, 0.3113727569580078, -0.19702227413654327, 0.31215739250183105, -0.1460956484079361, 0.052812423557043076, 0.32785022258758545, 0.3347427248954773, -0.35877853631973267, -0.04687311500310898, 0.25405335426330566, 0.16066288948059082, -0.25827762484550476, 0.09082847088575363, -0.21193169057369232, -0.3730202317237854, -0.4517008364200592, -0.25345852971076965, -0.3116559088230133, -0.25382593274116516, 0.15177038311958313, -0.16212940216064453, 0.0873795747756958, -0.33664509654045105, 0.0737462118268013, -1.1993263959884644, 0.4186576008796692, -0.03715468943119049, 0.30579322576522827, -0.5161086916923523, -0.2523013651371002, 0.268619179725647, -0.04252107813954353, 0.2706209421157837, -0.3064558207988739, -0.4632623791694641, -0.28947752714157104, 0.3109539747238159, -0.7743479013442993, 0.0433729849755764, 0.1317131221294403, -0.23374691605567932, 0.5202817320823669, 0.18627095222473145, 0.28033408522605896, 0.10900355130434036, -0.1828010380268097, -0.5235964059829712, -0.3578057587146759, -0.19048663973808289, 0.012246710248291492, -0.1141151487827301, 0.4004242420196533, -0.33231210708618164, 0.005814068950712681, 0.08937665075063705, -0.35053056478500366, 0.3434043228626251, 0.03165378421545029, -0.35009342432022095, 0.4229458272457123, 0.43225163221359253, -0.06812670081853867, 0.7075748443603516, 0.33007559180259705, -0.537939190864563, 0.4829508662223816, -0.5595588684082031, -0.07207873463630676, 0.13764190673828125, -0.3919626772403717, 0.2206706702709198, 0.3690986931324005, -0.17205168306827545, 0.1159997209906578, 0.5650669932365417, -0.4123527705669403, 0.12065840512514114, 0.07263725250959396, -0.6938814520835876, 0.6482935547828674, 0.23210157454013824, -0.17196346819400787, -0.5008167028427124, -0.15799227356910706, 0.06745458394289017, -0.27617573738098145, -0.5105702877044678, 0.35350096225738525, -0.64417564868927, -0.282419353723526, 0.04032626748085022, 0.0012012767838314176, -0.1879812777042389, -0.13547934591770172, -0.03905534744262695, 0.10218538343906403, -0.3374001681804657, -0.012317326851189137, 0.0008520338451489806, 0.8686035871505737, -0.277373343706131, 0.20717750489711761, -0.2755431532859802, -0.00003491745519568212, 0.03842240571975708, -0.322769433259964, -0.03139825910329819, 0.5437598824501038, 0.333658367395401, 0.8167502880096436, -0.4824238121509552, -0.0411829873919487, 0.08554968982934952, 0.1519468128681183, 0.4374312162399292, 0.4113696217536926, 0.675223171710968, 0.1281288117170334, -0.5267886519432068, -0.5748271346092224, -0.3183368742465973, 0.021738849580287933, -0.3295781910419464, -0.5373727083206177, -0.39745187759399414, 0.36796849966049194, -0.022353462874889374, -0.10915486514568329, -0.025530099868774414, 0.015882743522524834, 0.002693732501938939, -0.34283462166786194, -0.7356528639793396, 0.4672841429710388, 0.44537264108657837, -0.12199859321117401, -0.06958809494972229, -0.07022778689861298, 0.10702691972255707, 0.01044069416821003, -0.5392577648162842, 0.040834639221429825, 0.21900323033332825, 0.19938550889492035, 0.3428500294685364, 0.6413980722427368, 0.3780534565448761, 0.07518570870161057, -0.0807991549372673, -0.5206499099731445, 0.24260136485099792, -0.49858444929122925, -0.48310813307762146, -0.0007868215325288475, 0.12367428839206696, 0.12520426511764526, 0.24071893095970154, -0.4640430212020874, -0.7800107598304749, 0.13029712438583374, -0.19634637236595154, 0.16234426200389862, -0.5796809792518616, -0.20004521310329437, -0.11212705820798874, -0.43423187732696533, -0.809891939163208, -0.6559164524078369, -0.05740653723478317, -0.04950456693768501, 0.7003929018974304, -0.5293505787849426, 1.119591474533081, -0.22694973647594452, -0.32997459173202515, 0.8826594948768616, -0.06192602217197418, -0.4535095989704132, -0.13014982640743256, 0.12085587531328201, 0.1319257915019989, 0.07854263484477997, -0.24594378471374512, 0.2205381989479065, -0.11824219673871994, 0.3069402873516083, 0.400291383266449, -0.15988314151763916, 0.2623244822025299, -0.40936046838760376, 0.13725531101226807, 0.14872922003269196, 0.48284438252449036, -0.6937134861946106, -0.5265792608261108, 0.28099673986434937, 0.006817372981458902, -0.3040129542350769, 0.23893195390701294, -0.7442386150360107, 0.26602160930633545, 0.8447315692901611, -0.23206549882888794, 0.9132711887359619, 0.5302898287773132, 0.23284463584423065, 1.052095651626587, -0.29932987689971924, 0.12341631948947906, -0.4888489842414856, -0.043783996254205704, -0.492232084274292, -0.36370575428009033, -0.07560794800519943, 0.19657497107982635, -0.2215559333562851, -0.09838561713695526, -0.40164557099342346, -0.10200074315071106, -0.05976063013076782, -1.1101324558258057, -0.06513126194477081, 0.15401746332645416, -0.4781484305858612, -0.4978041648864746, 0.5251567959785461, -0.7145976424217224, 0.14819560945034027, -0.11142869293689728, 0.858561098575592, 0.09754584729671478, -0.8511574268341064, 0.2855171263217926, 0.2556416690349579, -0.2790403366088867, -0.08394213765859604, 0.5446003675460815, -0.33401885628700256, -0.1706397384405136, 0.21794092655181885, -0.3013360798358917, 0.22832131385803223, -0.3405056297779083, -0.4701206088066101, 0.10874554514884949, -0.19568410515785217, 0.7173247933387756, 0.5138139724731445, 0.6951258778572083, -0.19023576378822327, -0.7233625054359436, 0.013921776786446571, -0.4141448736190796, -0.47471195459365845, -0.24227893352508545, 0.14401032030582428, 0.09378785640001297, -0.7038301229476929, -0.21694651246070862, -0.04513363540172577, 0.277873694896698, 0.10865148156881332, -0.5046383142471313, 0.25541219115257263, 0.11586148291826248, -0.07925093173980713, 0.20162120461463928, -0.15049505233764648, -0.5744580030441284, 0.38997334241867065, -0.2797727584838867, 0.3162953555583954, 0.040147848427295685, 0.18134805560112, -0.30106252431869507, -0.06818888336420059, 0.33551591634750366, -0.5326241850852966, -0.5340622663497925, 0.5370412468910217, 0.21310022473335266, -0.01697000116109848, 0.12687577307224274, 0.4265720248222351, -0.1146254613995552, 0.32955050468444824, -5.9074554443359375, -0.04093056544661522, -0.09357444941997528, -0.14044782519340515, 0.35306355357170105, -0.006714754272252321, 0.45699799060821533, 0.21426820755004883, 0.3935641348361969, 0.11125309020280838, 0.39602434635162354, 0.17061325907707214, -0.38010069727897644, 0.534378707408905, 0.13384142518043518, -0.19410300254821777, -0.3044886589050293, -0.09471332281827927, 0.4316619336605072, 0.04670482128858566, -0.3036382794380188, 0.006528545171022415, 0.4886454939842224, 0.7199086546897888, -0.5438235998153687, 0.07422037422657013, -0.6156041026115417, -0.15890826284885406, -0.5236972570419312, -0.11996590346097946, -0.39373740553855896, -0.38303306698799133, 0.005263983272016048, -0.18556354939937592, 0.6010673642158508, -0.07288937270641327, -0.31683066487312317, 0.02604621648788452, -0.2893817126750946, -0.08964146673679352, 0.3370193839073181, 0.540584921836853, 0.10865579545497894, -0.04673271253705025, 0.17010213434696198, 0.008705482818186283, -0.3785352110862732, 0.005820638500154018, -0.20470952987670898, 1.0455214977264404, 0.11618683487176895, -0.06102771684527397, 0.5091769695281982, 0.1914188265800476, 0.49852854013442993, -0.04796001315116882, 0.36526384949684143, -0.5270349383354187, -0.770563006401062, -0.1418464332818985, -0.031753893941640854, -0.24327336251735687, -0.4139169156551361, -0.5870469808578491, -0.16084355115890503, 0.1477406620979309, -1.0767886638641357, -0.13287664949893951, 0.8027210831642151, -0.14551861584186554, -0.4247646629810333, -0.2972140908241272, -0.015121979638934135, -0.6024346947669983, 0.40764689445495605, -0.18410558998584747, -0.30731356143951416, 0.20313498377799988, 0.42602744698524475, -0.39908576011657715, -0.22316353023052216, -0.3417796492576599, -0.04726763069629669, -0.37605342268943787, 0.24675136804580688, -0.36842110753059387, -0.2769213318824768, 0.03282347321510315, 0.22066502273082733, 0.543401300907135, 0.9105293154716492, -0.06822054833173752, -0.05672946572303772, 0.47900331020355225, 0.4690190851688385, 0.46547845005989075, 0.011318830773234367, 0.6431707739830017, 0.6368020176887512, 0.045169491320848465, 0.8454306125640869, -0.16497330367565155, -0.6052852272987366, -0.04541908577084541, -0.3937688171863556, 0.40950024127960205, -0.6073439121246338, -0.14475393295288086, 0.28317776322364807, -0.8030734062194824, 0.1316204071044922, -0.02152935415506363, -0.06357096880674362, -0.4237017333507538, 0.34090787172317505, -0.6047614216804504, -0.34290117025375366, 0.9080657362937927, 0.35514724254608154, -0.5367465019226074, 0.25608891248703003, 0.3872987926006317, -0.8374730944633484, 0.467230886220932, -0.10822752118110657, 0.3948964774608612, -0.0010230396874248981, 0.7832319140434265, -0.35274428129196167, -0.19483517110347748, 0.2770618200302124, -0.14770689606666565, 0.07184010744094849, 0.0727996677160263, 0.005256154108792543, -0.4192095696926117, -0.29308077692985535, 0.4051671028137207, -0.04288659989833832, -0.3180224597454071, 0.2427845299243927, -0.1968386471271515, -0.07716850191354752, 0.009609175845980644, 0.2080412656068802, -0.44889193773269653, -0.3850627839565277, -0.03153137490153313, -0.09221982210874557, 0.2120147943496704, 0.4842768907546997, -0.3443659842014313, 0.40312135219573975, 0.39344269037246704, -0.3805958330631256, 0.21198400855064392, 0.37426596879959106, 0.18332211673259735, 0.406130313873291, -0.20507851243019104, 0.12131576985120773, 0.1064474880695343, -0.8358160257339478, -0.12488917261362076, -0.2756035625934601, -0.07795150578022003, 0.010016693733632565, -0.5511099696159363, -0.27676159143447876, -0.12581796944141388, -0.3833451569080353, -0.07670549303293228, 0.07659188657999039, 0.12725281715393066, -0.05230245366692543, -0.3148297369480133, -0.2770817279815674, 0.050051044672727585, -0.04090775176882744, 0.2137453705072403, -0.20795504748821259, -0.5621839165687561, -0.10264673084020615, -0.5019107460975647, -0.024382542818784714, -0.07062840461730957, 0.32795077562332153, -0.4258157014846802, -0.2991352379322052, -0.6309652924537659, 0.35217899084091187, 0.38975033164024353, 0.44891002774238586, -0.32660436630249023, 0.02556956186890602, 0.47608980536460876, -0.036085568368434906, 0.6888495683670044, 0.276025652885437, -0.595365047454834, 0.19139987230300903, -0.002109982306137681, -0.7056530714035034, 0.581926703453064, 0.5716965198516846, -0.23768556118011475, 0.48029083013534546, 0.019753722473978996, 0.003153308294713497, 0.19439756870269775, -0.27588769793510437, -0.3043040633201599, 0.3126365542411804, 0.4698922634124756, -0.3185657560825348, -0.22982168197631836, -0.03626006469130516, -0.4925419092178345, 0.023600077256560326, 0.6758738160133362, 0.22362925112247467, 0.40463870763778687, -0.2148105502128601, -0.3388974666595459, -0.23880763351917267, -0.05597810819745064, 0.43293675780296326, -0.5871537923812866, 0.29390549659729004, -0.23441515862941742, 0.26566436886787415, -0.13713183999061584, 0.2690121531486511, -0.12894712388515472, -0.45727482438087463, -0.501238226890564, 0.05296481400728226, 0.11283770203590393, 0.18666015565395355, 0.6626942753791809, 0.7884339094161987, 0.6212965846061707, -0.3330126106739044, 0.3002593517303467, 0.12681975960731506, 0.8229696750640869, 0.33115434646606445, -0.6539553999900818, -0.4378587007522583, -0.03283470869064331, 0.6539756059646606, -0.3063603341579437, 0.024666154757142067, 0.17400628328323364, 0.683999240398407, -0.3355242609977722, -0.20826300978660583, 0.0497276671230793, 0.16606354713439941, 0.09485109150409698, -0.12317470461130142, -0.38173753023147583, 0.2763504683971405, 0.0070504997856915, 0.20355777442455292, 0.22248661518096924, -0.13991807401180267, -0.31760621070861816, 0.3427827060222626, -0.22893112897872925, 0.43501555919647217, 0.050503116101026535, 0.8903481364250183, -0.332004576921463, 0.09148406982421875, -0.1484508365392685, 0.20393531024456024, 0.25725284218788147, 0.3961728811264038, -0.1375575065612793, -0.010141901671886444, -0.5939685106277466, 0.32341694831848145, -0.1401907503604889, 0.7416897416114807, -0.7437103390693665, 0.13293035328388214, -0.27289241552352905, -0.04843393713235855, -0.15766702592372894, -0.359617680311203, 0.33140063285827637, 0.08163508772850037, -0.5377321839332581, -0.02224872075021267, 0.15979169309139252, 0.08391354978084564, 0.664206326007843, 0.12885457277297974, 0.5083827376365662, -0.6275149583816528, 0.003846239298582077, 0.5146892666816711, -0.8272189497947693, 0.1617729216814041, 0.3336617350578308, -0.04019784927368164, -0.565825879573822, -0.9082111120223999, 0.04729064553976059, -0.24135735630989075, 0.17620162665843964, 0.38531172275543213, -0.4183361232280731, -0.1708400994539261, 0.12084518373012543, 0.20109298825263977, -0.33651742339134216, 0.6871843338012695, 0.32173243165016174, 0.6262822151184082, 0.6935945153236389, 0.11953101307153702, -0.09604544192552567, -0.09981232136487961, -0.07982002198696136, -0.006349504459649324, 0.3890683054924011, 0.21573509275913239, 0.3396160304546356, 0.5427036881446838, -0.2120329588651657, 0.3869437575340271, 0.9895215034484863, 0.25269684195518494, 0.06118754670023918, 0.3752790689468384, -0.9051735997200012, -0.22180712223052979, 0.015027197077870369, 0.6256105303764343, 0.795295238494873, 0.186967670917511, -0.45809727907180786, -0.0029894481413066387, 0.5169220566749573, 0.08341988176107407, 0.23324601352214813, -0.2081533670425415, 0.35201936960220337, 0.5151239633560181, -0.791401743888855, 0.1653968095779419, 0.24840635061264038, -0.36785587668418884, 0.054498590528964996, 0.6349229216575623, -0.18056167662143707, -0.30101630091667175, 0.2548399269580841, -0.877323567867279, 0.11690448969602585, -0.2576541602611542, 0.6339091658592224, -0.06199866905808449, -0.0850873589515686, 0.6891971826553345, 0.09449923783540726, 0.467845618724823, -0.3111513555049896, 0.10090108215808868, 0.11058846116065979, -0.4034506678581238, 0.1013001874089241, -0.18114738166332245, -0.4148311913013458, 0.1731727123260498, 0.24503101408481598, 0.38545119762420654, -0.11523374170064926, -0.3472491204738617, 0.13570721447467804, 0.01735018566250801, -0.3213439881801605, -0.20885886251926422, -0.31315651535987854, -0.11033643782138824, -0.14639724791049957, -0.34185001254081726, 0.45155200362205505, -0.38725385069847107, -0.28729429841041565, 0.5706236362457275, -0.03961847722530365, 0.1337989866733551, 0.528261125087738, -0.1617404669523239, 0.08107176423072815, 0.34708768129348755, 0.010719959624111652, -0.2283511906862259, 0.4819246828556061, -0.3945935070514679, 0.22477811574935913, -0.33689939975738525, 0.35267913341522217, -0.07409282773733139, 0.20532481372356415, -0.4627457559108734, -0.02184569276869297, 0.6279280185699463, 0.637244701385498, -0.32657596468925476, 0.11482029408216476, 0.4683741629123688, 0.510962963104248, 0.3646133542060852, -0.15600182116031647, -0.26961785554885864, -0.3960387110710144, -0.025126738473773003, -0.38090452551841736, 0.7450771331787109, -0.293426513671875, -0.2112996131181717, -0.01113917212933302, 0.46418893337249756, 0.6141924262046814, -0.6698923707008362, 0.49111634492874146, -0.3769390285015106, -0.015375210903584957, -0.7675475478172302, -0.0004148073785472661, -0.3509255051612854, 0.06186338886618614, -0.3470859229564667, -0.06352374702692032, 0.5278884172439575, -0.5794795155525208, 0.4553951621055603, 0.2052377462387085, 0.28337669372558594, -0.2575025260448456, 0.3101091980934143, 0.02262802980840206, 0.045132365077733994, -0.48946285247802734, -0.6457094550132751, 0.15989087522029877, 0.2733578085899353, -0.7552586197853088, -0.11609559506177902, -0.07724130153656006, -0.05528712645173073, -0.11031627655029297, 0.13936229050159454, -0.025454068556427956, -0.4392024874687195, 0.6677283644676208 ]
Tumor recurrence represents a major clinical challenge. Our data show that emergent recurrent tumors acquire a phenotype radically different from that of their originating primary tumors. This phenotype allows them to evade a host-derived innate immune response elicited by the progression from minimal residual disease (MRD) to actively growing recurrence. Screening for this innate response predicted accurately in which mice recurrence would occur. Premature induction of recurrence resensitized MRD to the primary therapy, suggesting a possible paradigm shift for clinical treatment of dormant disease in which the current expectant approach is replaced with active attempts to uncover MRD before evolution of the escape phenotype is complete. By combining screening with second-line treatments targeting innate insensitivity, up to 100% of mice that would have otherwise relapsed were cured. These data may open new avenues for early detection and appropriately timed, highly targeted treatment of tumor recurrence irrespective of tumor type or frontline treatment.
[ 0.0013291139621287584, 0.010965469293296337, -0.009950084611773491, 0.017923783510923386, 0.02286456525325775, 0.0023737349547445774, 0.008639306761324406, 0.009721831418573856, -0.010921074077486992, -0.005354807246476412, 0.008864718489348888, 0.009114719927310944, 0.011041444726288319, 0.005657254718244076, -0.03562358394265175, 0.040916942059993744, -0.02275429666042328, -0.021229945123195648, -0.00014861120143905282, 0.0030837664380669594, 0.007881712168455124, -0.009846910834312439, 0.009351778775453568, 0.0047626132145524025, 0.0038953465409576893, 0.003010907443240285, -0.01280220691114664, -0.015672601759433746, -0.016334909945726395, -0.01338602602481842, -0.016852429136633873, 0.014127561822533607, 0.010473106056451797, 0.037595298141241074, 0.005745940841734409, -0.020263150334358215, -0.00003327330341562629, 0.020410923287272453, 0.008662926033139229, -0.003916544374078512, 0.013957306742668152, -0.008834224194288254, 0.003609240986406803, -0.006637724116444588, -0.007217541337013245, 0.0004571898025460541, 0.0004390710673760623, -0.006407515145838261, -0.011401286348700523, 0.0034699314273893833, 0.00217991741374135, -0.008585645817220211, -0.01644427888095379, 0.013501658104360104, -0.005985475145280361, 0.017825793474912643, 0.01785796880722046, 0.006256554741412401, 0.0028096551541239023, -0.002071849536150694, 0.003990672528743744, -0.029713772237300873, 0.005722580477595329, -0.004751130007207394, -0.02197355218231678, -0.06729063391685486, 0.032928213477134705, 0.011123614385724068, -0.009212654083967209, 0.014310365542769432, -0.0007563079707324505, 0.005660658702254295, -0.01199960894882679, 0.053205978125333786, -0.02981778234243393, -0.009982612915337086, -0.012375921942293644, -0.005407361313700676, 0.007364240474998951, 0.029761523008346558, 0.0005626436322927475, -0.007201634347438812, 0.005277978256344795, 0.005509858950972557, -0.008981287479400635, 0.00928077194839716, -0.02286377362906933, -0.009164780378341675, 0.0011211242526769638, 0.004339667968451977, -0.01989472284913063, -0.015815360471606255, -0.03596595302224159, -0.0024607081431895494, -0.032000087201595306, 0.011002615094184875, -0.004535720683634281, -0.002897897968068719, 0.027263972908258438, -0.006446776911616325, -0.022609492763876915, 0.0051314206793904305, 0.019151899963617325, 0.022334024310112, -0.001102229580283165, 0.007075674366205931, 0.004169953987002373, 0.016456007957458496, 0.03749201446771622, 0.004221726208925247, -0.0023205801844596863, -0.025996103882789612, -0.01833615079522133, 0.006004601251333952, -0.0037698415108025074, -0.004095679614692926, 0.012459201738238335, 0.02451273985207081, 0.010666189715266228, 0.015730716288089752, 0.001303130411542952, -0.00971787516027689, -0.005320042371749878, -0.00368801923468709, 0.0004409194807521999, 0.011188741773366928, -0.016774367541074753, 0.012268888764083385, 0.0010642181150615215, 0.0050494777970016, -0.009234162978827953, -0.0063224071636796, 0.014555969275534153, -0.0251319482922554, 0.0018140611937269568, 0.0018958681030198932, 0.009121541865170002, -0.01067365426570177, 0.0025473148562014103, -0.001311957836151123, 0.002079662401229143, 0.011282451450824738, -0.00577150471508503, 0.007569259963929653, -0.030206480994820595, 0.004331897012889385, -0.003984464332461357, 0.003335308050736785, 0.010404844768345356, -0.03234301880002022, 0.02601083181798458, -0.0025086922105401754, -0.01135233324021101, -0.011474363505840302, 0.002653904724866152, 0.012220863252878189, -0.01626605913043022, -0.01990559697151184, 0.0001231171190738678, 0.019427495077252388, 0.012588974088430405, -0.014597052708268166, 0.000017866957932710648, 0.007115262560546398, 0.009144270792603493, 0.006098661571741104, 0.005905806086957455, -0.0016985717229545116, -0.00048474944196641445, 0.0020487604197114706, 0.006021518260240555, 0.012718409299850464, -0.027220364660024643, 0.009152375161647797, 0.008972658775746822, -0.005042131990194321, -0.01209796592593193, 0.004734891001135111, -0.007893304340541363, 0.06727932393550873, 0.007951495237648487, -0.0018276260234415531, -0.005261369980871677, -0.000832987017929554, 0.0155127989128232, -0.014528672210872173, 0.02666838839650154, -0.008209153078496456, -0.014051936566829681, -0.0013601488899439573, 0.001594283152371645, 0.022833481431007385, -0.007270462810993195, 0.0075373658910393715, -0.0032510943710803986, 0.002549072727560997, 0.02105674147605896, 0.0032326870132237673, 0.004447938408702612, -0.013639850541949272, 0.012840742245316505, 0.007679678034037352, 0.019230805337429047, -0.005040212068706751, 0.0036091762594878674, 0.002944394014775753, 0.015553539618849754, -0.0018997746519744396, -0.014889655634760857, 0.008090164512395859, 0.04204002022743225, -0.012998642399907112, -0.003791821887716651, -0.0065152947790920734, 0.033612243831157684, 0.011175533756613731, 0.019116224721074104, -0.01713097095489502, -0.027302315458655357, -0.013679116033017635, 0.0027598850429058075, 0.012393391691148281, 0.007619705982506275, -0.003920805640518665, 0.013204348273575306, 0.007754969876259565, 0.011941341683268547, 0.008186649531126022, -0.012256331741809845, -0.01598663069307804, -0.008115580305457115, -0.03363558277487755, -0.007815229706466198, 0.004011243581771851, -0.001856176182627678, -0.004466331098228693, 0.008256997913122177, -0.015561316162347794, 0.01777556724846363, -0.009457457810640335, -0.008049550466239452, -0.008120407350361347, 0.026049312204122543, -0.003850910346955061, 0.024865780025720596, 0.013907862827181816, 0.02873443067073822, 0.002559731714427471, 0.005846098996698856, -0.02346956729888916, 0.006134982220828533, -0.02838076651096344, 0.024183239787817, 0.021290641278028488, 0.0030646584928035736, 0.002066396875306964, 0.006915501784533262, 0.00017918564844876528, 0.02360009029507637, -0.01365661434829235, 0.008626071736216545, 0.006002236157655716, 0.0013515898026525974, 0.007595038041472435, -0.024983638897538185, 0.01351195853203535, -0.020298399031162262, -0.00266822031699121, 0.023495614528656006, 0.01735837012529373, 0.005278608296066523, -0.006506369449198246, -0.0019636843353509903, -0.08172982931137085, -0.0014148172922432423, 0.0011482875561341643, 0.0007137286011129618, 0.0073177022859454155, -0.02122575230896473, 0.023229606449604034, 0.017550839111208916, -0.0005635430570691824, 0.009466606192290783, 0.005977368913590908, -0.00035626068711280823, -0.011375164613127708, -0.0025394372642040253, -0.007527557201683521, -0.006514221429824829, 0.00486043281853199, -0.011141777038574219, -0.000390105415135622, -0.02593022957444191, 0.011854315176606178, 0.004861911293119192, 0.013509666547179222, 0.010477100498974323, -0.009609337896108627, 0.03244166821241379, 0.0011130692437291145, 0.02111686021089554, -0.0007747679483145475, -0.001964610069990158, -0.0070925187319517136, -0.02439616248011589, -0.020916614681482315, 0.010524309240281582, 0.0034956480376422405, 0.003131268545985222, -0.026813361793756485, -0.01955377869307995, -0.01896551623940468, 0.005776030942797661, 0.010172608308494091, 0.009900752454996109, 0.0002404616679996252, -0.003650018945336342, 0.010563325136899948, 0.023442545905709267, 0.004063411615788937, 0.004143726080656052, 0.011080531403422356, 0.00322653423063457, 0.011673117987811565, 0.0038398108445107937, 0.0012225445825606585, 0.00942728016525507, 0.00047186820302158594, -0.030660128220915794, -0.0009959847666323185, -0.031806718558073044, -0.012074175290763378, -0.001728474977426231, -0.0021193288266658783, -0.006176061928272247, 0.002543624024838209, 0.01681670919060707, 0.0013360613957047462, -0.021967142820358276, 0.008830212987959385, -0.005410649348050356, -0.009823484346270561, 0.020505066961050034, -0.004517653025686741, -0.0037965900264680386, 0.010963615030050278, -0.012794431298971176, 0.01941670849919319, -0.01139749027788639, -0.01664995402097702, -0.006454451009631157, 0.030224032700061798, -0.0003383968723937869, -0.022517787292599678, -0.007723230868577957, -0.00861956924200058, -0.009383546188473701, -0.022400185465812683, 0.003932379186153412, 0.006021022796630859, 0.031347811222076416, 0.01577356830239296, -0.011478504166007042, 0.031516753137111664, 0.027381625026464462, -0.0011192914098501205, 0.00795666128396988, 0.00823757704347372, 0.004360808990895748, -0.01662329211831093, -0.011342158541083336, 0.010442343540489674, 0.008295027539134026, -0.01789160631597042, -0.00017966667655855417, -0.01842854917049408, -0.004423920065164566, -0.003238049801439047, 0.0096355602145195, 0.01739843748509884, -0.014419161714613438, -0.006381225306540728, -0.00456621078774333, 0.0003741774708032608, -0.005791505333036184, -0.002449717605486512, 0.02951142191886902, 0.011859112419188023, 0.015577208250761032, -0.001585859339684248, -0.022913867607712746, 0.07250458002090454, -0.0032134626526385546, -0.010437387973070145, -0.003789021633565426, -0.0020104290451854467, -0.0307912714779377, -0.01123034954071045, 0.03314261510968208, 0.013048543594777584, 0.005574911832809448, 0.010865546762943268, -0.013734979555010796, -0.0012321015819907188, -0.019935132935643196, -0.01730838045477867, -0.004666095599532127, -0.0012895655818283558, 0.03688919171690941, -0.007409218233078718, -0.010789068415760994, 0.03746763616800308, -0.00046309269964694977, -0.019216617569327354, 0.00111443642526865, 0.010386948473751545, -0.04056680202484131, -0.004325240850448608, -0.016206800937652588, -0.00551691185683012, 0.007056214846670628, 0.005877235904335976, -0.02770834043622017, 0.0007520109647884965, -0.002276471583172679, 0.029628917574882507, 0.005490443203598261, 0.02158498577773571, -0.008320494554936886, -0.0009989739628508687, 0.0012971417745575309, -0.03728629648685455, -0.015353400260210037, 0.008126933127641678, 0.020243804901838303, -0.023586280643939972, 0.0044050803408026695, 0.017315329983830452, -0.006343506276607513, -0.005697084125131369, 0.011187007650732994, -0.015825489535927773, 0.010945488698780537, 0.012340414337813854, 0.004874907433986664, 0.01179465837776661, -0.011838333681225777, 0.02005128562450409, -0.02292460948228836, 0.0072291092947125435, -0.013023744337260723, 0.0005756684113293886, -0.03090708889067173, 0.020192522555589676, -0.016583651304244995, -0.001170160248875618, -0.01876194030046463, -0.002851298078894615, -0.004993894603103399, 0.031272586435079575, -0.030643150210380554, 0.03116225078701973, -0.0033261682838201523, -0.010401048697531223, -0.015007112175226212, -0.016199875622987747, 0.047634780406951904, -0.004901854321360588, -0.024638233706355095, 0.015240443870425224, 0.010956496931612492, -0.010967280715703964, -0.0040959566831588745, 0.023461462929844856, -0.009380489587783813, 0.019505281001329422, -0.015672646462917328, -0.018930241465568542, -0.0750192403793335, -0.01283170934766531, 0.012054508551955223, -0.010464627295732498, 0.02037971094250679, 0.02807013690471649, 0.0038553655613213778, -0.0021796063520014286, 0.008005717769265175, -0.0062063876539468765, 0.0314202755689621, -0.018878204748034477, 0.02191026136279106, -0.00928003154695034, 0.011397048830986023, 0.011318882927298546, -0.0046790302731096745, -0.008463134057819843, -0.008689232170581818, 0.0005706811789423227, 0.018325325101614, -0.013812458142638206, -0.025240400806069374, 0.012917885556817055, 0.002592164557427168, -0.08134427666664124, 0.011402727104723454, -0.01607833057641983, -0.01333102211356163, -0.010041098110377789, -0.01103118434548378, -0.0018444876186549664, -0.011080259457230568, -0.022586269304156303, -0.015264058485627174, 0.010484866797924042, 0.002237152773886919, 0.014188828878104687, 0.003914430737495422, 0.012576248496770859, -0.012428775429725647, 0.013166426680982113, -0.011652856133878231, -0.0300239659845829, -0.031345680356025696, -0.008279703557491302, 0.02627221681177616, -0.0070870970375835896, -0.019165685400366783, -0.009437576867640018, -0.013155054301023483, -0.016143344342708588, 0.008093176409602165, -0.009179503656923771, 0.00757503742352128, 0.008321907371282578, -0.0010647037997841835, -0.010783093050122261, -0.010244307108223438, 0.008286405354738235, -0.015052279457449913, 0.02076876536011696, -0.007289196364581585, 0.050375744700431824, -0.017684679478406906, -0.007080037146806717, 0.02263416349887848, -0.0002801792579703033, 0.015098748728632927, -0.0015290146693587303, 0.001679572043940425, 0.005336155649274588, -0.0018798623932525516, -0.00002121517900377512, 0.02346901223063469, 0.009536271914839745, -0.02113206312060356, -0.0071809496730566025, 0.006075026001781225, -0.02119196206331253, 0.022303089499473572, 0.004560620058327913, -0.007905889302492142, -0.014139862731099129, 0.015186108648777008, -0.006987735163420439, -0.02684151567518711, -0.030747029930353165, 0.07237309217453003, -0.026056915521621704, 0.02440132200717926, -0.03178153932094574, 0.007590878289192915, 0.0019341825973242521, -0.04540817439556122, 0.0030307318083941936, 0.0014373376034200191, -0.02674357034265995, 0.028439383953809738, -0.017648356035351753, 0.006900816690176725, 0.010109543800354004, -0.003488481743261218, -0.00014168419875204563, -0.012608552351593971, -0.018800735473632812, 0.004892115946859121, -0.017879551276564598, -0.010683652944862843, 0.023287110030651093, -0.03316566348075867, -0.01761258766055107, 0.017834965139627457, 0.00391505379229784, -0.003953148145228624, -0.02024177834391594, -0.03329665958881378, 0.008517427369952202, 0.000536761712282896, 0.025257520377635956, -0.0009205177193507552, -0.033046871423721313, 0.019011277705430984, 0.002628045156598091, -0.003327160608023405, 0.004367721267044544, -0.007306775078177452, 0.010158899240195751, -0.0054685091599822044, 0.0017395736649632454, 0.0035214265808463097, -0.0011669928207993507, 0.03272777050733566, -0.006200944073498249, 0.00777887087315321, -0.004591420292854309, 0.0032636697869747877, 0.01935706101357937, -0.022524548694491386, 0.005327105522155762, 0.008061900734901428, -0.014033647254109383, 0.01556623075157404, 0.03085842914879322, -0.0183999203145504, 0.016915742307901382, 0.017470762133598328, 0.008126330561935902, -0.0016685326118022203, -0.00890970230102539, -0.003617786103859544, -0.021387772634625435, 0.014991062693297863, -0.007451571058481932, 0.002517357934266329, -0.016407888382673264, -0.010589035227894783, 0.016116328537464142, -0.01205962523818016, 0.0011626299237832427, 0.006756242364645004, -0.0010836594738066196, 0.030473951250314713, 0.007739693857729435, -0.006802104413509369, 0.04088064283132553, 0.004164531826972961, 0.016098517924547195, -0.013775987550616264, -0.006904015317559242, 0.0013779629953205585, -0.0038729775696992874, -0.010324698872864246, 0.017363401129841805, 0.002918556798249483, -0.02311958372592926, -0.007321393582969904, 0.00606165174394846, 0.03844868391752243, 0.0012693202588707209, -0.00004001334309577942, 0.03184777870774269, 0.005415480583906174, 0.03377756476402283, -0.000386181753128767, 0.0043058013543486595, 0.00004670675843954086, 0.0007408865494653583, -0.003934544511139393, -0.023772042244672775, -0.023131389170885086, -0.015958527103066444, -0.009031361900269985, 0.0028408500365912914, 0.011703936383128166, -0.02352873980998993, -0.003781969426199794, -0.01972736045718193, 0.0006939391605556011, -0.02328701689839363, 0.01425926387310028, 0.007908684201538563, -0.002558141015470028, 0.04471448436379433, 0.002629730151966214, 0.0018927408382296562, 0.02784835360944271, -0.007869235239923, -0.011180896311998367, -0.00027780490927398205, -0.028932373970746994, 0.01602323353290558, 0.014783328399062157, -0.0033745979890227318, -0.008961204439401627, 0.0008421903476119041, -0.011537831276655197, -0.004836300387978554, 0.021783381700515747, 0.007895585149526596, -0.014675596728920937, 0.0215362049639225, -0.008472571149468422, -0.01512206345796585, 0.029121464118361473, -0.03647088631987572, 0.01488119550049305, 0.0064448826014995575, 0.0021761618554592133, -0.0066880276426672935, 0.003610605373978615, -0.026621369644999504, 0.007472120225429535, -0.03466247767210007, 0.042913950979709625, -0.024167601019144058, 0.01167411357164383, 0.00046089175157248974, -0.0017261693719774485, 0.011743694543838501, 0.03005688451230526, -0.00437505915760994, 0.021770650520920753, 0.01569249853491783, 0.016063017770648003, 0.027242090553045273, 0.0012638855259865522, 0.013500400818884373, 0.013157431036233902, -0.026291891932487488, 0.0029668293427675962, -0.009506212547421455, -0.004632981494069099, 0.0005666313227266073, 0.027852077037096024, 0.01859939470887184, 0.003933912143111229, -0.015671629458665848, 0.020083822309970856, -0.0020362981595098972, -0.0013936245813965797, 0.0031631600577384233, -0.02802552655339241, -0.017142226919531822, -0.014848951250314713, -0.004198544658720493, -0.0048683700151741505, -0.014087673276662827, -0.0037828702479600906, -0.007480781525373459, 0.011937761679291725, -0.011581660248339176, -0.012029517441987991, -0.007721048314124346, -0.00586816668510437, 0.021170999854803085, 0.009511109441518784, -0.007659757509827614, -0.017025038599967957, -0.016843164339661598, 0.003116590203717351, 0.011018171906471252, 0.007483330555260181, 0.0030314153991639614, 0.009939824230968952, -0.021077025681734085, -0.0093760434538126, -0.0009237277554348111, 0.003391674254089594, -0.006697126664221287 ]
[ -0.14665788412094116, -0.2578924000263214, 0.5697693824768066, 0.13770245015621185, 0.44861850142478943, 0.24315647780895233, 0.22448311746120453, 0.16058121621608734, -0.35725900530815125, -0.3616600036621094, 0.07767325639724731, 0.5492061972618103, -0.24253498017787933, 0.6293689608573914, -0.22568173706531525, 0.5847256183624268, 0.4486740231513977, -0.06338725984096527, -0.22014766931533813, -0.25831717252731323, -0.48866817355155945, -0.5162851214408875, 0.44284340739250183, -0.0473504476249218, -0.1478547304868698, -0.3534202575683594, 0.40658965706825256, -0.2135605663061142, -0.012725734151899815, 0.04070496931672096, -0.33387327194213867, 0.14334940910339355, -0.04056844860315323, -0.379512220621109, -0.0599718801677227, 0.05704310163855553, -0.18039074540138245, -0.02835782803595066, -0.15263207256793976, -0.2955099642276764, 0.038083963096141815, -0.1469292938709259, -0.37194040417671204, 0.25737637281417847, -0.29348012804985046, -0.5719636082649231, -1.616226077079773, 0.25186559557914734, -0.02872447483241558, -0.34263738989830017, 0.3072074353694916, -0.05554070323705673, -0.04967940226197243, 0.19271482527256012, 0.1936608850955963, 0.08363193273544312, -0.5225042700767517, -0.3850689232349396, 0.24638251960277557, -0.24138125777244568, -0.25855952501296997, -0.4535938501358032, -0.4917907416820526, 0.487246036529541, -0.42041832208633423, 0.7215697765350342, 0.5064302682876587, -0.07219364494085312, -0.495670348405838, -0.5261610150337219, -0.15994524955749512, -0.38539135456085205, 0.3016456067562103, 0.4493832588195801, -0.3612504005432129, 0.4478999674320221, 0.12627628445625305, -0.39813393354415894, 0.01045256294310093, -0.214340478181839, 0.270809143781662, -0.07417502999305725, 0.34908396005630493, -0.00035132875200361013, 0.19734126329421997, -0.12624798715114594, 0.07004895806312561, 0.9178309440612793, -0.15062259137630463, 0.16147054731845856, -0.08995062112808228, 0.16766689717769623, 0.3205275237560272, 0.42882177233695984, 0.25011926889419556, 0.36656853556632996, 0.2229754626750946, -0.028043074533343315, 0.1413412243127823, 0.3301549255847931, -0.06573140621185303, 0.045333266258239746, 0.04352561756968498, -0.4746018648147583, -0.5489650368690491, -0.4338650703430176, -0.16671904921531677, -0.025598550215363503, -0.6805034875869751, 0.03942039608955383, -0.8827131390571594, 0.3869507908821106, -0.2092141956090927, -0.12439391762018204, -0.48120710253715515, 0.5186420679092407, 0.1434585452079773, -0.6286717057228088, -0.1712869554758072, -0.3733079135417938, 0.19033317267894745, 1.2347484827041626, -0.33177632093429565, 0.17924995720386505, -0.13016313314437866, 0.06611509621143341, 0.6070144772529602, 0.2098654806613922, -0.4282255470752716, 0.43297699093818665, 0.1859566569328308, 0.3793771266937256, -0.36388126015663147, -0.2031673640012741, 0.3128489851951599, -0.3409956991672516, 0.08597119897603989, 0.2286500632762909, 0.6038859486579895, -0.07299681752920151, -0.03281912952661514, -0.8804227709770203, -0.2986637353897095, 0.19800743460655212, 0.07759486883878708, -0.23916645348072052, 0.014431892894208431, -0.15874959528446198, -0.16880956292152405, -0.2821786403656006, -0.026672909036278725, 0.10675855726003647, -0.8126416802406311, -0.25908949971199036, -0.22959472239017487, 0.6621623635292053, 0.1226654052734375, -0.5222562551498413, 0.4479021728038788, 0.3147421181201935, -0.013968284241855145, 0.08444821089506149, -0.45053631067276, -0.18527591228485107, 0.35949328541755676, -0.39654919505119324, 0.41079068183898926, 0.19190311431884766, 0.011571413837373257, -0.1195313110947609, -0.9907528758049011, 0.10256209969520569, 0.08616361767053604, -0.7962144017219543, 0.4017711877822876, 0.04971133917570114, 0.518890917301178, 0.2521086633205414, 0.20006389915943146, -0.04117405042052269, -0.810464084148407, 0.08362894505262375, 0.21682995557785034, -0.3952428996562958, 0.18253828585147858, -0.2859852612018585, 0.31754687428474426, 0.06546942889690399, 0.4698587954044342, -0.0262755099684, -0.3462767004966736, 0.351226806640625, 0.7851548194885254, -0.5514814853668213, 1.1451205015182495, 0.1321977972984314, 0.047180045396089554, 1.7543542385101318, -0.29721003770828247, -0.031159089878201485, 0.3869746923446655, 0.07665299624204636, 0.5223022699356079, 0.07688245177268982, -0.6701177954673767, -0.29089057445526123, -0.00044068312854506075, -0.3067649006843567, 0.09532805532217026, 0.19321143627166748, 0.9709472060203552, -0.2764171063899994, -0.27091261744499207, -0.39311811327934265, 0.28254207968711853, 0.03889782726764679, -0.1392470747232437, -0.09557903558015823, -0.5894842743873596, -0.3305341601371765, 0.2839180827140808, -0.8105725646018982, 0.39382684230804443, 0.8653392791748047, 0.339185506105423, 0.829920768737793, 0.260476291179657, -0.2915615737438202, 0.7226818203926086, -0.23541317880153656, 0.14060384035110474, -0.11894695460796356, 0.1511794626712799, -0.3617900609970093, 0.07525207102298737, 0.41460102796554565, 0.024470912292599678, -0.1874825656414032, -0.2527647018432617, -0.015181503258645535, -0.30017250776290894, 0.17240168154239655, -0.5610406994819641, 0.6105517148971558, -0.1423332393169403, -0.3441298007965088, -0.4729066491127014, 0.08113197237253189, -0.7945283651351929, -0.2183111310005188, 0.07922743260860443, 0.3832513093948364, 0.2376207709312439, -0.5489420294761658, 0.4389558732509613, 0.06513363122940063, 0.011648272164165974, -0.15360908210277557, -0.026992280036211014, -0.4552823305130005, -0.13274742662906647, 0.7228766679763794, 0.30632463097572327, 0.33949801325798035, -0.33280304074287415, -0.41913172602653503, -0.3656417727470398, -0.5946321487426758, 0.37766826152801514, 0.5462440848350525, 0.17297117412090302, 0.15790919959545135, -0.8359660506248474, -0.06988556683063507, -0.49753865599632263, -0.5262324810028076, -0.37982040643692017, 0.95916348695755, -0.5372610688209534, 0.10043615102767944, 0.13702505826950073, 0.5951696634292603, 0.7268053293228149, -0.3654714822769165, -0.4829951524734497, 0.2667889893054962, -0.06876003742218018, -0.3237663805484772, -0.6891260147094727, 0.0795968621969223, -0.5761442184448242, 0.16274800896644592, -0.3210230767726898, 0.3169090151786804, -0.0684303492307663, -0.031356021761894226, -0.06467942148447037, -0.02053697034716606, 0.7143192887306213, 0.19580775499343872, -0.47570547461509705, -0.04822252690792084, -0.2201053947210312, -0.1058558002114296, -0.39391836524009705, -0.3138760030269623, -0.4691449701786041, 0.47059518098831177, -5.8696489334106445, -0.3752939999103546, -0.07918773591518402, -0.0033884074073284864, -0.14112231135368347, 0.07331478595733643, 0.4817531108856201, 0.20903219282627106, 0.3728722035884857, -0.09121481329202652, 0.6715033054351807, 0.531065821647644, 0.020360924303531647, 0.260143905878067, -0.2629683315753937, -0.1841711401939392, 0.42514798045158386, 0.47163626551628113, 0.35187777876853943, -0.20870375633239746, 0.5248059034347534, -0.19914796948432922, 0.17476746439933777, 0.45739230513572693, 0.1568146049976349, 0.7483770251274109, -0.856268048286438, 0.3717384934425354, -0.6169440746307373, -0.16069327294826508, 0.14839957654476166, -0.32154935598373413, 0.1637919545173645, 0.04647863656282425, -0.106883704662323, 0.4007973074913025, 0.06438559293746948, 0.08091884851455688, 0.027827465906739235, -0.6832236647605896, 0.21886804699897766, -0.33640429377555847, -0.6397719383239746, 0.10034225136041641, 0.15361309051513672, 0.0677073523402214, 0.43293997645378113, 0.33175578713417053, -0.3009105622768402, 0.6200148463249207, 0.1460442841053009, -0.2301667332649231, 0.47033265233039856, 0.6946523785591125, 0.2401314675807953, -0.02010243944823742, -0.3571840822696686, -0.1010255217552185, -0.44155073165893555, 0.18278983235359192, -0.4310801327228546, -0.08844321966171265, -0.14454667270183563, -0.4756230115890503, -0.21720682084560394, 0.02668147161602974, -0.3881033957004547, -0.5918160080909729, 1.009381890296936, -0.16494475305080414, -0.4712027609348297, 0.7187660932540894, 0.5174821019172668, -0.45005032420158386, 0.5151047110557556, 0.0035898899659514427, 0.125326469540596, 0.04733680188655853, 0.019271522760391235, -0.543846607208252, -0.45911023020744324, -0.09026750177145004, 0.1599566787481308, -0.18876446783542633, 0.24218834936618805, -0.23633375763893127, -0.13873837888240814, 0.29523301124572754, 0.0731562152504921, 0.3976009786128998, 0.3482649028301239, -0.3105705976486206, 0.35301974415779114, 0.08600800484418869, 0.4057775139808655, 0.8016452789306641, 0.4724353551864624, 0.1945420205593109, 0.6505982875823975, 0.06989361345767975, 0.6404876112937927, 0.019414234906435013, -0.22521081566810608, -0.7962129712104797, -0.13857831060886383, -0.23181180655956268, -0.4458322525024414, -0.12133029103279114, 0.415842741727829, -0.7838413715362549, 0.4130091071128845, 0.18129050731658936, -0.1310003101825714, -0.5404131412506104, 0.18190735578536987, -0.41999560594558716, -0.09403671324253082, 0.19266563653945923, 0.6557198166847229, -0.04020122066140175, 0.1872384399175644, 0.25316333770751953, -0.3197823464870453, 0.28037917613983154, 0.540867030620575, -0.1687576025724411, 0.1667352020740509, 0.9932065010070801, -0.617996335029602, 0.00048591531231068075, 0.1449095606803894, 0.37674733996391296, -0.2924755811691284, -0.03441767394542694, 0.23477594554424286, -0.6768269538879395, -0.028759045526385307, 0.0974707156419754, -0.16295550763607025, -0.0022684335708618164, 0.28822463750839233, -0.13394510746002197, -0.17627933621406555, 0.36320021748542786, 0.07213234901428223, -0.31409987807273865, 0.2746574282646179, 0.06461984664201736, 0.1160886138677597, -0.20052814483642578, 0.03922352194786072, -0.01816309429705143, 0.42954087257385254, -0.40988966822624207, -0.07468590885400772, 0.3430010676383972, 0.3869013786315918, -0.09479475021362305, -0.05764678493142128, -0.4313400983810425, 0.10385241359472275, 0.1249462142586708, -0.7429537177085876, -0.2489560842514038, -0.14861871302127838, -0.053236961364746094, -0.5005635023117065, -0.6257028579711914, 0.16032780706882477, 0.5088363885879517, -0.27671390771865845, -0.2492758184671402, -0.8080430030822754, -0.18035702407360077, 0.4652644097805023, -0.3175130784511566, -0.2840278446674347, 0.17981629073619843, 0.16656814515590668, 0.09416893869638443, 0.3173048496246338, -0.6959382891654968, -0.5481802225112915, 0.5912201404571533, 0.9905722737312317, -0.04631205275654793, 0.12962864339351654, -0.4386095702648163, -0.6363834738731384, -0.489699125289917, 0.18046998977661133, 0.09816928207874298, 0.4867471158504486, -0.27321213483810425, 0.3445909917354584, -0.17335808277130127, -0.2844705879688263, 0.7068224549293518, 0.28493422269821167, -0.03699728474020958, 0.16559235751628876, 0.4949099123477936, -0.3239488899707794, 0.38827094435691833, 0.7375248670578003, -0.1708088517189026, -0.027215050533413887, -0.1508844494819641, 0.2939220368862152, -0.07688845694065094, -0.220402330160141, -0.3215487599372864, 0.37334558367729187, 0.6491245627403259, -0.05223501846194267, -0.16985762119293213, -0.3594970703125, -0.5625856518745422, -0.0942656546831131, 0.43018853664398193, 0.5467500686645508, -0.21101489663124084, -0.1270267367362976, 0.22111721336841583, -0.6706850528717041, 0.2958659827709198, 0.4256649613380432, -0.9010211825370789, -0.10174643248319626, -0.01872413046658039, 0.025176482275128365, -0.6877009272575378, -0.01858307607471943, -0.2778364419937134, -0.1198301613330841, -0.211739644408226, 0.5281350016593933, 0.2342112511396408, -0.08414468169212341, 0.2547514736652374, 0.285319060087204, 0.7354910373687744, -0.3428105115890503, -0.3806634545326233, -0.3520932197570801, 0.30060121417045593, 0.4207417368888855, -0.9757518768310547, -0.7536949515342712, 0.5100957751274109, 0.2244608998298645, -0.1929263323545456, 0.11089985072612762, -0.0072209835052490234, 0.5688057541847229, 0.13346907496452332, -0.2111884504556656, -0.5748951435089111, -0.47735878825187683, 0.28922006487846375, -0.017128754407167435, -0.2399861216545105, -0.1786954551935196, -0.41568514704704285, 0.6261224150657654, -0.08927926421165466, -0.0340208001434803, -0.41006311774253845, 0.24895882606506348, -0.6873044371604919, 0.08151856064796448, -0.4291017949581146, 0.5660303831100464, 0.5330009460449219, -0.034987714141607285, 0.5232751965522766, -0.16886499524116516, -0.08727256208658218, -0.38697555661201477, 0.4870814383029938, 0.11323104053735733, -0.5473042130470276, -0.3709506392478943, -0.4455423057079315, 0.3050677180290222, -0.5178806185722351, 0.4530166983604431, -0.2236897349357605, 0.2744722068309784, 0.17990298569202423, -0.5453996658325195, 0.09345149248838425, -0.3756774663925171, -0.32297733426094055, -0.2003496140241623, 0.28316664695739746, 0.3019699156284332, 0.4335269629955292, -0.22159340977668762, -0.30001211166381836, -0.3913913667201996, 0.6812179684638977, 0.24274399876594543, -0.9171958565711975, 0.44837474822998047, 0.26650166511535645, 0.06728620827198029, 0.1881786733865738, -0.33691778779029846, 0.01827947609126568, 0.346805214881897, -0.06098723039031029, 0.32347339391708374, 0.41769731044769287, -0.08532285690307617, -0.0275683905929327, -0.45886868238449097, -0.37101224064826965, 0.32221701741218567, 0.037556588649749756, -0.0133215906098485, 0.9057941436767578, 0.3472875654697418, -0.4776473939418793, -0.33303019404411316, 0.4152231514453888, -0.2668072283267975, -0.02989315614104271, 0.014035994186997414, 0.1699705868959427, 0.5644443035125732, 0.2779490053653717, -0.4758044481277466, 0.5845537185668945, 0.32287517189979553, -0.0054997666738927364, 0.44031375646591187, -0.8018444180488586, -0.425382137298584, -0.03806031495332718, 1.0050402879714966, 0.17293497920036316, 0.05218016728758812, 0.06711029261350632, -0.2813461422920227, 0.4177783727645874, 0.776091456413269, 0.3063025176525116, 0.06024124100804329, -0.09072773903608322, 0.1673194169998169, -0.4717525839805603, -0.6084334254264832, 0.12030638009309769, -0.1339440941810608, -0.2603752017021179, 0.2963812053203583, -0.6146524548530579, -0.05373435467481613, 0.10644371807575226, -0.07777781039476395, -0.1758912205696106, -0.4291040003299713, 0.34794092178344727, 0.11219697445631027, -0.23106735944747925, 0.7394262552261353, 0.2612355351448059, 0.3737584352493286, 0.11128073930740356, 0.0477629192173481, 0.07082290202379227, 0.09487152099609375, 0.0506051704287529, 0.57917720079422, -0.6343543529510498, -0.033868975937366486, 0.2768552005290985, -0.2238381803035736, 0.2765607237815857, -0.14213067293167114, -0.02481662854552269, 0.2888559401035309, -0.0754084512591362, -0.1017259955406189, -0.23335318267345428, -0.25598374009132385, -0.07884371280670166, 0.40731942653656006, 0.16292932629585266, 0.2638625204563141, -0.2898898124694824, 0.12347085028886795, 0.38811346888542175, 0.2794874608516693, -0.04434248059988022, -0.0002480428956914693, 0.058062732219696045, -0.04480055719614029, 0.532414972782135, -0.12172994762659073, 0.4254958927631378, -0.05215437710285187, 0.6163697838783264, -0.9660789966583252, 0.1615913063287735, -0.2977113425731659, -0.3908141553401947, -0.5485749244689941, 0.2514294683933258, 0.50535649061203, 0.5307480096817017, -0.47610294818878174, -0.007898533716797829, -0.6189008951187134, -0.22388850152492523, 0.33608242869377136, -0.391588419675827, -0.18274414539337158, -0.8784859776496887, 0.00646338053047657, -0.2550429105758667, 0.6703201532363892, -0.15397462248802185, -0.4282225966453552, -0.866165041923523, 0.5545084476470947, 0.30195295810699463, -0.07306164503097534, 0.3061749339103699, -0.5834023356437683, 0.09689570963382721, -0.4921213388442993, 0.2602475583553314, -0.7164367437362671, 0.06733037531375885, 0.12474466115236282, -0.02346568927168846, -0.09820117056369781, -0.10996029525995255, 0.091739222407341, -0.5856773257255554, 0.4678706228733063, 0.24368001520633698, 0.4626483619213104, 0.04543785750865936, -0.041085802018642426, -0.3713831305503845, -0.28077033162117004, 0.21306641399860382, 0.025773659348487854, -0.24562981724739075, 0.40918949246406555, 0.22528934478759766, -0.22460027039051056, 0.1315188854932785, -0.12922772765159607, -0.24103805422782898, -0.4628438949584961, -0.07383573055267334 ]
During development, mechanical forces cause changes in size, shape, number, position, and gene expression of cells. They are therefore integral to any morphogenetic processes. Force generation by actin-myosin networks and force transmission through adhesive complexes are two self-organizing phenomena driving tissue morphogenesis. Coordination and integration of forces by long-range force transmission and mechanosensing of cells within tissues produce large-scale tissue shape changes. Extrinsic mechanical forces also control tissue patterning by modulating cell fate specification and differentiation. Thus, the interplay between tissue mechanics and biochemical signaling orchestrates tissue morphogenesis and patterning in development.
[ -0.02966720424592495, 0.021130815148353577, -0.021062403917312622, 0.026441633701324463, 0.008181223645806313, -0.010847518220543861, 0.012912394478917122, -0.0048448387533426285, -0.017156586050987244, -0.013278711587190628, -0.009820234030485153, 0.027944276109337807, -0.01191730611026287, 0.024189583957195282, 0.016759010031819344, 0.004136102274060249, 0.005930880084633827, -0.009184467606246471, 0.0051913694478571415, -0.03950510919094086, -0.027524972334504128, -0.011900078505277634, 0.012920912355184555, -0.011308287270367146, 0.008891159668564796, 0.00041493598837405443, -0.013428522273898125, -0.006388369016349316, 0.010122708976268768, 0.006843469105660915, -0.013344835489988327, -0.009917255491018295, 0.00828238669782877, 0.02404722198843956, 0.0041957879438996315, 0.0022520432248711586, 0.0009780338732525706, 0.03594588488340378, 0.040763430297374725, -0.005460535176098347, 0.04096532613039017, -0.009995078667998314, 0.006555701605975628, -0.010407884605228901, -0.01112436130642891, -0.01724289357662201, 0.003200388513505459, 0.023459376767277718, -0.00974065251648426, 0.00924757495522499, -0.02492203749716282, -0.005771970842033625, 0.00023618806153535843, 0.01398451253771782, -0.00840386375784874, -0.012366141192615032, 0.023134345188736916, -0.03499250113964081, 0.008300933986902237, 0.012470826506614685, -0.004177629482001066, -0.01469738595187664, 0.020617667585611343, 0.0022250288166105747, 0.0013153236359357834, -0.06610710918903351, 0.0013134991750121117, -0.0031523541547358036, -0.0023060236126184464, 0.02140619233250618, 0.006991332862526178, 0.010302973911166191, 0.0025701886042952538, -0.004191597457975149, 0.01823752000927925, -0.018216971307992935, -0.023928692564368248, 0.004528554156422615, 0.007454786449670792, 0.027011141180992126, -0.0004174928180873394, -0.01708897203207016, 0.022964611649513245, 0.021034039556980133, 0.00031417887657880783, 0.03321366012096405, -0.031554222106933594, 0.01987684704363346, -0.004010054282844067, 0.03055085428059101, 0.01754121109843254, 0.017626779153943062, 0.023565776646137238, -0.01643296889960766, -0.03486865758895874, 0.02559659630060196, 0.015226488932967186, -0.038851141929626465, 0.005477492231875658, 0.029722828418016434, -0.030929936096072197, 0.008434951305389404, 0.01857689395546913, 0.014073081314563751, 0.0011531857308000326, 0.013364309445023537, 0.003036574926227331, 0.005536932498216629, 0.022129986435174942, 0.01736592873930931, -0.007544843479990959, 0.016295650973916054, -0.0016940892674028873, 0.03547368943691254, -0.013506072573363781, -0.010229341685771942, -0.007322287652641535, 0.005631946958601475, 0.022549785673618317, -0.037710390985012054, 0.03174937143921852, -0.0013588443398475647, 0.0008643961045891047, 0.026761367917060852, 0.003995172213762999, -0.02185395173728466, -0.023022156208753586, 0.0006519295275211334, 0.01023273915052414, 0.0005722030764445662, -0.015522314235568047, 0.023214975371956825, -0.00002984423190355301, -0.0017045196145772934, 0.0021227088291198015, -0.002294157864525914, -0.04172634333372116, -0.018473301082849503, -0.0001627206802368164, -0.01940966583788395, 0.03263884037733078, 0.008260213769972324, 0.007197810802608728, 0.003855779767036438, 0.006620695814490318, -0.018503036350011826, -0.04584842175245285, 0.01713019795715809, 0.006975584197789431, 0.01345022115856409, 0.023560460656881332, 0.00007970724254846573, -0.01933842897415161, -0.024547679349780083, -0.009921355172991753, 0.010021936148405075, -0.03241666778922081, -0.01632925122976303, -0.0023330282419919968, 0.008746170438826084, -0.01815289817750454, -0.012645070441067219, 0.03582831472158432, 0.011618350632488728, 0.020732464268803596, -0.029226671904325485, -0.003950536251068115, -0.01632566936314106, -0.017092883586883545, 0.010894775390625, -0.0008587053744122386, -0.03448180854320526, 0.002190775005146861, 0.010947169736027718, -0.01701192930340767, 0.0030070310458540916, 0.0002855854108929634, 0.007411191705614328, -0.017474927008152008, 0.06643272191286087, -0.005188061855733395, -0.011907612904906273, -0.02871185541152954, -0.01743796467781067, -0.002214954234659672, -0.014421612024307251, 0.004589155316352844, -0.017753468826413155, 0.025763237848877907, -0.007523820269852877, 0.005287350155413151, -0.009793095290660858, -0.00870768167078495, -0.011771116405725479, -0.028970282524824142, 0.004347058944404125, 0.02193537913262844, -0.005729189142584801, -0.029303867369890213, -0.01163517776876688, -0.03655768185853958, -0.03847809135913849, 0.03926784545183182, -0.0016461779596284032, -0.014533692970871925, 0.005441087298095226, -0.0020268899388611317, -0.034176621586084366, -0.004726981744170189, 0.012531023472547531, -0.0013619414530694485, 0.003963228315114975, -0.008114919997751713, 0.00846210028976202, 0.007861848920583725, 0.005301949568092823, -0.014201108366250992, 0.008391991257667542, 0.002095339819788933, -0.013541962951421738, 0.0042756241746246815, 0.008731191977858543, 0.013143626973032951, 0.008194628171622753, 0.008292021229863167, 0.0006563193164765835, -0.010157322511076927, 0.020869188010692596, 0.0037207903806120157, 0.008782426826655865, -0.016391634941101074, -0.002743188291788101, -0.011652247048914433, 0.03098839893937111, 0.00396969448775053, 0.002586785238236189, 0.019030237570405006, -0.009396690875291824, 0.03193209692835808, -0.006441047415137291, -0.004900236148387194, 0.0043266536667943, 0.03933173045516014, -0.03787790611386299, 0.03791193664073944, 0.002612258307635784, -0.0059961723163723946, 0.007589380256831646, 0.021929975599050522, -0.011656377464532852, 0.010837760753929615, -0.01865965686738491, 0.024952180683612823, 0.026858512312173843, 0.00244903820566833, -0.03339347243309021, 0.021017244085669518, 0.026445530354976654, 0.026995301246643066, -0.008444487117230892, -0.006980909034609795, 0.00870604906231165, 0.015161982737481594, -0.010235628113150597, -0.020311031490564346, -0.007469360716640949, 0.04645037651062012, 0.04004751145839691, 0.041443150490522385, 0.0009840596467256546, 0.0046350713819265366, -0.003603300778195262, -0.003366381861269474, -0.08062656223773956, -0.016251832246780396, -0.00030428916215896606, -0.003509288188070059, 0.006346267648041248, -0.0009158104658126831, 0.03817196935415268, 0.0051795123144984245, -0.01495094783604145, 0.016496457159519196, -0.003408451797440648, -0.023018214851617813, -0.009894778952002525, 0.0005685626529157162, -0.026932600885629654, -0.011640417389571667, 0.017370037734508514, -0.00040522776544094086, 0.037021540105342865, -0.0068331072106957436, 0.006156959105283022, -0.037371665239334106, -0.019146032631397247, 0.008907582610845566, -0.02123267389833927, 0.024313030764460564, 0.009306355379521847, 0.005790072027593851, -0.027995942160487175, 0.020671814680099487, -0.016321077942848206, 0.007541791535913944, 0.02601238340139389, -0.011239264160394669, 0.030319441109895706, 0.010621888563036919, -0.006488341838121414, -0.008333812467753887, -0.02479281648993492, 0.016321808099746704, 0.0002708511892706156, 0.013615742325782776, 0.026629548519849777, 0.021415336057543755, 0.009562868624925613, -0.007989920675754547, 0.015614772215485573, -0.003347158432006836, 0.017007283866405487, 0.015496606938540936, 0.00016545969992876053, 0.0015651488211005926, -0.005502982996404171, 0.02152761071920395, -0.01951618865132332, -0.03824499994516373, -0.010511258617043495, -0.02446058765053749, -0.012034215964376926, -0.0037601615767925978, 0.029621271416544914, 0.024567605927586555, -0.02471115067601204, -0.011107413098216057, -0.006797892041504383, -0.01993381790816784, 0.010708817280828953, -0.003188645001500845, -0.017387209460139275, 0.01494937390089035, 0.047280848026275635, 0.006301977671682835, -0.0008745640516281128, -0.005033259280025959, -0.02523369900882244, -0.006772167980670929, -0.01963038742542267, -0.015444018878042698, 0.011309477500617504, -0.007396267261356115, -0.03649502247571945, -0.006496676709502935, -0.009971976280212402, 0.004289185628294945, -0.03753992170095444, -0.01580718532204628, 0.002721160650253296, 0.014468200504779816, 0.023143190890550613, -0.02158348262310028, -0.0044541265815496445, 0.025383198633790016, -0.025138188153505325, 0.009148458018898964, 0.0077432384714484215, 0.007992696017026901, 0.012741734273731709, -0.03748496621847153, -0.0024761236272752285, 0.012670914642512798, -0.03333527222275734, 0.013925504870712757, -0.0031761471182107925, -0.01145416684448719, -0.02334350347518921, 0.01668051816523075, 0.010181870311498642, -0.030311165377497673, 0.004442495293915272, -0.007967241108417511, -0.033304255455732346, 0.003032019827514887, -0.005898468196392059, -0.00879752915352583, 0.017285918816924095, 0.0031188903376460075, -0.0013484269147738814, -0.030223913490772247, 0.07056000828742981, -0.026949536055326462, -0.006461872719228268, -0.02025287039577961, 0.03773404657840729, -0.027326229959726334, 0.020530274137854576, 0.013807252049446106, -0.0180220827460289, -0.021957701072096825, 0.015888772904872894, -0.009644229896366596, 0.027707060799002647, 0.03559790924191475, -0.028735153377056122, 0.0007724885363131762, -0.005645647644996643, 0.022011205554008484, -0.0008645644411444664, 0.010022561997175217, -0.0058447010815143585, -0.014948827214539051, -0.016817981377243996, -0.0193866528570652, 0.009055152535438538, -0.042803674936294556, -0.04670799523591995, -0.010259316302835941, -0.009625920094549656, 0.01514236256480217, 0.021740809082984924, -0.040769025683403015, -0.0020667759235948324, -0.011141614057123661, 0.03363306075334549, 0.005888753570616245, 0.02514120563864708, -0.007640152703970671, -0.02450643852353096, 0.0018645650707185268, 0.02151966094970703, -0.014704125933349133, 0.02148650400340557, 0.028500717133283615, -0.008952905423939228, -0.01746957190334797, 0.0451769083738327, -0.006429136265069246, -0.01469491608440876, -0.02233266271650791, -0.030992507934570312, 0.010453732684254646, 0.011423114687204361, 0.014439395628869534, 0.023074669763445854, 0.02187035232782364, -0.014468876644968987, -0.0006609844858758152, 0.026194147765636444, -0.006949547678232193, -0.009610332548618317, 0.011052063666284084, 0.037177830934524536, -0.04712587967514992, -0.009635614231228828, -0.012292668223381042, -0.031207237392663956, -0.013881606049835682, -0.018910370767116547, -0.003314466681331396, 0.07106417417526245, 0.01850932091474533, -0.026890773326158524, -0.012804455123841763, -0.0020240899175405502, -0.02151934616267681, -0.01080394722521305, -0.024317480623722076, 0.03431730344891548, 0.029327047988772392, 0.006618712563067675, -0.03937245160341263, -0.0244368277490139, -0.015191974118351936, 0.02416188269853592, -0.01559332013130188, -0.024981848895549774, -0.07356405258178711, 0.026811707764863968, -0.0033931490033864975, -0.008916132152080536, 0.011787643656134605, 0.03605693206191063, -0.03401593118906021, 0.01429194025695324, 0.034264855086803436, -0.0036935005336999893, -0.006666515953838825, -0.022404616698622704, -0.0012696621706709266, -0.0016671201447024941, 0.013923905789852142, 0.013803726993501186, -0.006961293518543243, 0.006889719516038895, -0.04332447797060013, -0.012294953688979149, 0.0028221714310348034, 0.0035177236422896385, -0.009040513075888157, 0.0011478320229798555, 0.005495961755514145, -0.07908883690834045, 0.02811451628804207, -0.0023468497674912214, -0.004867881536483765, 0.0059920381754636765, -0.005216351710259914, -0.0028556252364069223, -0.019739123061299324, 0.013496830128133297, -0.019061289727687836, -0.017946328967809677, 0.001068083569407463, -0.028382161632180214, -0.00026017334312200546, 0.02750663086771965, -0.004176596645265818, -0.0009954599663615227, 0.03084973804652691, -0.01487450860440731, 0.00593116320669651, 0.007159947417676449, -0.0167384073138237, -0.020763512700796127, -0.013325291685760021, -0.010606545023620129, -0.03294011950492859, -0.004210813902318478, 0.006647560745477676, 0.01646428182721138, 0.03173292055726051, -0.028141088783740997, -0.01054910197854042, -0.02071145921945572, -0.019974295049905777, -0.0019744508899748325, -0.02733903005719185, 0.01069845724850893, -0.009979157708585262, 0.006581597961485386, -0.005599423311650753, -0.006284431554377079, -0.0069518121890723705, -0.009613670408725739, 0.019852472469210625, -0.021678967401385307, 0.023937227204442024, 0.00627717562019825, -0.0041870116256177425, 0.03274332359433174, -0.0221487358212471, 0.009722640737891197, -0.027646441012620926, -0.031576983630657196, -0.008252582512795925, -0.012813964858651161, 0.01760675385594368, -0.004321021027863026, 0.026599932461977005, 0.03282877057790756, 0.0099842119961977, -0.0027035893872380257, -0.0004603669513016939, 0.00711674802005291, 0.07113272696733475, -0.023693576455116272, 0.008549414575099945, 0.019502168521285057, 0.008131083101034164, 0.0019363629398867488, -0.03450363874435425, -0.01734546385705471, -0.014324523508548737, -0.006486987695097923, 0.03477437049150467, -0.021997913718223572, -0.023589743301272392, 0.019192446023225784, 0.012006533332169056, 0.015979662537574768, 0.01989429071545601, -0.014022987335920334, -0.009215346537530422, 0.011023925617337227, -0.017429327592253685, -0.030895067378878593, -0.01713992841541767, 0.009131098166108131, -0.020404193550348282, -0.011485446244478226, -0.051082778722047806, -0.01667362079024315, 0.00018869806081056595, 0.0030503608286380768, -0.0033537407871335745, 0.018201734870672226, -0.010300529189407825, -0.04339975118637085, 0.032669439911842346, 0.051622174680233, -0.012020345777273178, 0.0009327949956059456, -0.030766215175390244, 0.04965291544795036, -0.03445688635110855, 0.03754870593547821, 0.004228736739605665, 0.0029439879581332207, -0.007751914672553539, 0.0119291041046381, -0.012349497526884079, -0.009766055271029472, 0.001216559554450214, -0.005507095251232386, 0.030286720022559166, -0.006116868928074837, 0.014238502830266953, 0.01773112267255783, 0.012029480189085007, -0.004355990327894688, 0.019889218732714653, 0.018093619495630264, -0.02624579705297947, -0.02999286539852619, 0.011530701071023941, -0.013441726565361023, -0.0400899313390255, -0.0180092491209507, 0.016175860539078712, 0.02810119278728962, 0.028483320027589798, -0.013329138979315758, -0.005111477337777615, 0.019388601183891296, -0.02463366650044918, 0.028337931260466576, 0.009874843992292881, 0.017650626599788666, 0.03846530616283417, 0.004305962473154068, 0.019044179469347, -0.02398981899023056, 0.012849547900259495, 0.02656107395887375, -0.012533754110336304, 0.023098856210708618, -0.0014035895001143217, 0.018395058810710907, 0.027854902669787407, -0.018053770065307617, -0.01183844730257988, -0.01352428738027811, 0.0003323549753986299, 0.01614738255739212, 0.024525385349988937, -0.022986045107245445, 0.002089981222525239, -0.000796501524746418, 0.01319502480328083, 0.03603440523147583, 0.0408022478222847, 0.0004038024926558137, 0.005572384223341942, 0.012440135702490807, -0.017883367836475372, -0.007967250421643257, 0.01711266115307808, -0.01698259823024273, -0.02459612488746643, 0.004692383110523224, 0.012548494152724743, 0.01996801607310772, -0.016645049676299095, 0.008308963850140572, -0.018586264923214912, 0.01182989776134491, 0.0031694925855845213, 0.010718466714024544, 0.0003381171263754368, -0.01687525399029255, -0.017405807971954346, -0.028612246736884117, -0.014709513634443283, -0.011213673278689384, 0.0005653486587107182, 0.002148821484297514, -0.009770117700099945, 0.0051926514133811, -0.01779092103242874, -0.012506696395576, -0.022337397560477257, 0.04685855656862259, 0.0029521454125642776, -0.004995327442884445, 0.016846423968672752, -0.022657837718725204, -0.021398667246103287, 0.03704756498336792, 0.01801040582358837, 0.02540472149848938, 0.01345224492251873, -0.003675467101857066, -0.031941309571266174, 0.013281312771141529, 0.02172209322452545, 0.003925667144358158, -0.000369225163012743, 0.049087390303611755, 0.006027899216860533, 0.012878594920039177, 0.05643268674612045, 0.019916720688343048, 0.017075829207897186, -0.023828011006116867, 0.002882036380469799, -0.0016075288876891136, 0.01998945139348507, -0.008927468210458755, -0.02064293436706066, 0.029949920251965523, 0.012795398943126202, -0.04680034518241882, -0.0029296204447746277, -0.008736233226954937, 0.00009379838593304157, 0.009793246164917946, -0.0022937417961657047, 0.015598148107528687, 0.021809156984090805, -0.005536092910915613, -0.014459426514804363, 0.01455007866024971, -0.04699581116437912, 0.04374057799577713, -0.01147674210369587, 0.0050847758539021015, -0.0262245275080204, 0.010100835002958775, -0.033877309411764145, -0.0214206762611866, -0.005222665145993233, -0.012055166065692902, 0.02521979622542858, 0.008154665119946003, 0.045935697853565216, -0.004371726419776678, 0.002007614355534315, -0.006162991747260094, 0.015195830725133419, -0.005691035650670528, -0.0022356235422194004, 0.002135570626705885, -0.003042875323444605, 0.02029792219400406, 0.008754681795835495, -0.01320506352931261, -0.004303434398025274, 0.006289864890277386, -0.037674084305763245, -0.03083088994026184, 0.04926133155822754, -0.007942313328385353, 0.008840852417051792, 0.012185685336589813, 0.021434631198644638, -0.01639838144183159 ]
[ 0.17052233219146729, 0.03503333032131195, 0.35195717215538025, -0.18561150133609772, 0.36913907527923584, 0.275961309671402, -0.006100879982113838, -0.1276073157787323, -0.04424804076552391, -0.9319412708282471, -0.038387611508369446, 0.48744651675224304, -0.2237967848777771, 0.5521016120910645, -0.416965514421463, 0.20767739415168762, 0.5124219059944153, 0.2524926960468292, -0.3841427266597748, -0.01783200539648533, -0.42548471689224243, -0.07062846422195435, 0.26080700755119324, 0.27511870861053467, 0.43382295966148376, -0.8073839545249939, 0.337149977684021, 0.05841566249728203, 0.5217555165290833, 0.07476991415023804, -0.26135286688804626, 0.19692888855934143, -0.5231103301048279, -0.1849846988916397, -0.32671743631362915, -0.17950014770030975, -0.33578336238861084, -0.171534463763237, -0.09839305281639099, -0.2942926287651062, -0.26489007472991943, -0.007576072588562965, 0.09602449834346771, 0.25753360986709595, -0.07393661886453629, -0.04397618770599365, -1.5058468580245972, 0.28218433260917664, -0.315628319978714, -0.2699640393257141, -0.020245365798473358, 0.1991761475801468, 0.43508559465408325, -0.020647810772061348, 0.06432951986789703, 0.06520834565162659, -0.134149968624115, 0.08906697481870651, 0.3970223069190979, -0.9140598773956299, 0.4466882050037384, 0.32896289229393005, -0.1571272760629654, 0.3196367621421814, 0.016652638092637062, 0.28695768117904663, 0.27320683002471924, -0.22359897196292877, -0.5438180565834045, -0.35832566022872925, -0.23155944049358368, -0.22580231726169586, -0.13266219198703766, 0.2808729410171509, -0.5472728610038757, 0.08711729198694229, -0.0367274172604084, -0.4475826919078827, 0.06825347244739532, 0.10568590462207794, -0.05843633413314819, 0.5170571804046631, 0.5448338389396667, -0.22942917048931122, 0.6192622780799866, 0.1726199835538864, -0.29563868045806885, 0.657013475894928, -0.552282452583313, 0.012217597104609013, -0.06637419015169144, -0.19051387906074524, 0.3686211109161377, 0.35816770792007446, 0.4706096947193146, 0.025723105296492577, 0.41382935643196106, -0.0760168805718422, -0.33340004086494446, 0.43484607338905334, -0.1663299947977066, -0.03573020547628403, -0.2854791581630707, -0.4133245348930359, 0.04522830620408058, -0.7498425841331482, -0.06925083696842194, -0.624399721622467, -0.33098307251930237, 0.35014861822128296, -0.9783756136894226, -0.524885356426239, -0.20179808139801025, -0.003970508463680744, -0.1156611368060112, -0.3045838177204132, -0.2319135069847107, -0.0006259679794311523, -0.09451160579919815, 0.29717597365379333, -0.0808151438832283, 0.6493867039680481, -0.45019862055778503, 0.25729143619537354, -0.06868142634630203, -0.09369468688964844, 0.2311435043811798, 0.32011526823043823, -0.5218768119812012, -0.06328531354665756, 0.2646627724170685, 1.0517271757125854, -0.20219814777374268, -0.06721705198287964, 0.3846178352832794, -0.02390526980161667, 0.1718384027481079, 0.45659366250038147, -0.0005100247799418867, 0.044584520161151886, -0.42835912108421326, -0.41930922865867615, 0.06205282732844353, 0.010780051350593567, -0.11765123158693314, -0.8937847018241882, 0.13311845064163208, -0.38613539934158325, -0.2941344380378723, -0.2086491882801056, -0.1952153891324997, 0.22111676633358002, -0.8551980257034302, 0.18359701335430145, -0.00034448440419510007, 0.5737365484237671, -0.21330009400844574, -0.14464515447616577, -0.27060678601264954, 0.0384029746055603, -0.33763498067855835, 0.09667084366083145, -0.4087512493133545, -0.2644568085670471, -0.07166656851768494, -0.5358588099479675, 0.9088043570518494, 0.5620347261428833, 0.1202554926276207, -0.1521027386188507, -0.27096226811408997, -0.30515140295028687, 0.2681439220905304, -0.046706151217222214, -0.22675244510173798, 0.08343978971242905, 0.5889111161231995, -0.11587808281183243, 0.12673376500606537, 0.041220974177122116, -0.5968592762947083, 0.14025385677814484, 0.07708030194044113, -0.10421420633792877, 0.5463231205940247, -0.24562016129493713, -0.07598234713077545, -0.18568702042102814, -0.04729229956865311, -0.4679540693759918, 0.346100777387619, 0.0010775647824630141, 0.467862606048584, -0.37757608294487, 0.977540910243988, -0.051122359931468964, -0.729831337928772, 1.2637031078338623, -0.28899073600769043, -0.14950986206531525, 0.28011783957481384, -0.10815627872943878, 0.12647652626037598, -0.25756973028182983, 0.03402263671159744, -0.20399780571460724, 0.38170963525772095, -0.025396492332220078, -0.1608661264181137, -0.31358107924461365, 0.37630903720855713, -0.18351493775844574, 0.08509452641010284, -0.56732177734375, 0.4397904872894287, -0.41303980350494385, -0.5942918062210083, 0.1619895100593567, -0.30392053723335266, -0.24069064855575562, 0.42476677894592285, -0.25009968876838684, -0.14094136655330658, 0.5017674565315247, 0.2076336145401001, 0.16224920749664307, 0.4732860326766968, 0.08480840921401978, 0.6225026249885559, -0.23449258506298065, 0.020045973360538483, -0.23510931432247162, -0.28130415081977844, -0.34352391958236694, -0.2133207619190216, 0.23373158276081085, 0.16754084825515747, 0.03586763143539429, -0.10729837417602539, -0.3033362329006195, 0.05189277231693268, 0.30556100606918335, -0.669677197933197, 0.13979975879192352, 0.0753602534532547, -0.3693464994430542, -0.19572071731090546, 0.05867277830839157, -0.6949732899665833, 0.3373206555843353, -0.5442296266555786, 0.3928025960922241, 0.5226650238037109, -0.20676583051681519, 0.3651876151561737, -0.5715919733047485, -0.31034567952156067, -0.1630369871854782, 0.28398481011390686, -0.017722295597195625, 0.3399876654148102, -0.4288545548915863, -0.346134752035141, 0.0640706717967987, -0.44278720021247864, -0.3342231810092926, -0.4545535147190094, -0.20703639090061188, 0.6541528701782227, 0.9142212271690369, 0.5953323245048523, 0.4663394093513489, -0.15689533948898315, -0.11810445785522461, -0.2639099061489105, -0.5078274011611938, 0.5040593147277832, -0.026867926120758057, -0.3188943564891815, -0.28373247385025024, 0.11271834373474121, 0.6368106007575989, 0.7300060391426086, -0.34972497820854187, 0.20176777243614197, 0.04585853964090347, 0.13480912148952484, -0.1447165161371231, -0.1119685024023056, 0.05112137272953987, -0.7071975469589233, 0.023645490407943726, -0.3941192626953125, 0.017714576795697212, 0.30749961733818054, 0.5851140022277832, -0.05245592072606087, -0.05831164866685867, 0.23422449827194214, -0.46308571100234985, -0.2604483664035797, 0.2835976779460907, -0.24593797326087952, -0.23485957086086273, -0.08136855810880661, 0.042797066271305084, -0.153442844748497, 0.3950779139995575, -6.0615949630737305, -0.26239660382270813, 0.050643060356378555, -0.2054041624069214, -0.11337456107139587, -0.13857051730155945, 0.4724673628807068, 0.37469205260276794, 0.15244369208812714, -0.08212075382471085, -0.24771033227443695, 0.21434371173381805, -0.3416069447994232, 0.4206731617450714, -0.11997408419847488, -0.003220402402803302, -0.044923387467861176, 0.16048592329025269, 0.11811118572950363, 0.3637087643146515, 0.04533257335424423, -0.7328968644142151, -0.09521391242742538, 0.6808432340621948, 0.01673208549618721, -0.38470813632011414, -0.8272731900215149, -0.05411122739315033, -0.4342915713787079, 0.06807080656290054, -0.46611663699150085, -0.49720147252082825, 0.02239563874900341, 0.11056188493967056, 0.7689836621284485, 0.4671798646450043, -0.24120476841926575, 0.024901576340198517, 0.7894118428230286, -0.5018118023872375, 0.2350262850522995, 0.4872048497200012, -0.4649304151535034, -0.12812648713588715, 0.16751985251903534, -0.2462652027606964, -0.08306745439767838, 0.5604686737060547, -0.7021780610084534, 1.0567920207977295, -0.1985328197479248, 0.009312278591096401, 0.614909291267395, -0.21398229897022247, 0.5670025944709778, 0.29636645317077637, 0.025210624560713768, -0.47801607847213745, -0.28099769353866577, -0.21535614132881165, -0.369064062833786, -0.38122087717056274, -0.24116291105747223, -0.4654225707054138, 0.24491459131240845, 0.21821914613246918, -0.8458194732666016, -0.35183778405189514, 0.3544234335422516, 0.1561010479927063, -0.02651507966220379, 0.5042669177055359, 0.24211029708385468, -0.6254299283027649, 0.5492415428161621, -0.33669185638427734, -0.07650647312402725, -0.03192276135087013, 0.41018810868263245, 0.0999920442700386, -0.2804386615753174, -0.15417996048927307, -0.07617030292749405, -0.2590494751930237, -0.12709644436836243, -0.16594797372817993, -0.16137808561325073, -0.4430370330810547, -0.19374410808086395, 0.28499096632003784, 1.0139379501342773, -0.12256374955177307, 0.18564525246620178, -0.05365336686372757, 0.5322696566581726, -0.017015235498547554, 0.07448536157608032, 0.29001906514167786, 0.2621815800666809, -0.320496141910553, 0.5945929288864136, -0.20824839174747467, -0.20185957849025726, -0.11318858712911606, 0.11287681758403778, 0.022884974256157875, -0.3467135429382324, 0.24587701261043549, 0.7768456339836121, -0.39890044927597046, -0.02612978219985962, 0.20801930129528046, -0.6324153542518616, -0.33712437748908997, 0.008992422372102737, -0.11609718203544617, -0.2825784683227539, 0.6859045624732971, 0.4257979691028595, -0.2804160714149475, 0.3570188879966736, 0.1273394525051117, -0.4821534752845764, -0.1647806316614151, 0.4410490095615387, 0.22461047768592834, -0.12894657254219055, 0.8613300323486328, -0.05660875886678696, -0.27824777364730835, 0.5353498458862305, 0.7932255268096924, -0.18029437959194183, 0.32503917813301086, -0.1713000386953354, -0.14105266332626343, -0.2082197666168213, 0.024653811007738113, -0.20558002591133118, -0.5306207537651062, 0.6511784791946411, 0.11699801683425903, 0.21901793777942657, -0.9144003391265869, 0.2768256664276123, 0.028130050748586655, -0.2410115748643875, 0.20356141030788422, -0.017455779016017914, -0.3241459131240845, 0.3902253210544586, -0.31883910298347473, -0.20089606940746307, -0.07885682582855225, -0.5940213203430176, -0.06903787702322006, 0.2637355625629425, -0.011286629363894463, 0.47576388716697693, -0.2608155310153961, 0.15622887015342712, 0.13976304233074188, -0.8379024267196655, -0.1864064335823059, -0.33976662158966064, 0.23402142524719238, -0.4831942617893219, -0.5025101900100708, -0.0728941410779953, 0.2099272906780243, -0.15856149792671204, -0.2620508372783661, -0.938448965549469, -0.49669840931892395, -0.11654666066169739, -0.35779115557670593, -0.0380430705845356, -0.2766374349594116, -0.11363767087459564, -0.14490625262260437, 0.1779627799987793, -0.6872110962867737, -0.343283087015152, -0.08307754248380661, 0.237642303109169, -0.07023800164461136, 0.2254619598388672, 0.07524710148572922, -0.1511048972606659, -0.5222206711769104, 0.08654751628637314, 0.2233482152223587, 0.19596527516841888, -0.42510712146759033, 0.2784149944782257, 0.44792991876602173, 0.04631597176194191, 0.7631300091743469, 0.023849084973335266, -0.7427307367324829, 0.06567712128162384, 0.22772134840488434, -0.7803415656089783, 0.3313088119029999, 0.6631671190261841, 0.046152420341968536, 0.07909681648015976, -0.10888120532035828, 0.49931013584136963, -0.09207253903150558, -0.3555257320404053, -0.3043334186077118, 0.020288512110710144, 0.053452491760253906, -0.3686191439628601, -0.2899932861328125, 0.2988986670970917, -0.3223062753677368, -0.40928536653518677, 0.1575136035680771, 0.20141743123531342, -0.18981698155403137, -0.5805662870407104, 0.15067274868488312, -0.16336439549922943, -0.5608740448951721, 0.16110199689865112, -0.3628934919834137, 0.33293044567108154, 0.22506657242774963, 0.15009304881095886, 0.06798439472913742, -0.08704416453838348, 0.17655830085277557, -0.16978049278259277, -0.5010674595832825, -0.3200012743473053, -0.0562700554728508, -0.492178350687027, 0.23778142035007477, 0.6483484506607056, 0.9281693696975708, -0.3849860727787018, 0.21408633887767792, 0.21082833409309387, 0.4475703239440918, 0.41545766592025757, -0.5035432577133179, -0.36863330006599426, -0.29166796803474426, 0.4576035141944885, -0.007184858433902264, -0.1491602659225464, 0.5895838737487793, 0.28464287519454956, 0.48172760009765625, -0.13820388913154602, -0.3679303824901581, 0.10247089713811874, 0.3856717050075531, -0.11335283517837524, -0.1624811291694641, -0.10934551060199738, -0.2520385980606079, 0.3195379078388214, 0.2755190134048462, -0.42954540252685547, -0.5745577812194824, 0.3295624852180481, -0.4863411784172058, 0.7353715896606445, 0.3476221263408661, 0.8456066846847534, 0.43696129322052, 0.1371820569038391, 0.16156232357025146, -0.13632149994373322, 0.4003249406814575, 0.14543293416500092, -0.16268058121204376, 0.2399623543024063, -0.14992213249206543, 0.10887928307056427, -0.5963962078094482, 0.6685807704925537, -0.4469928741455078, 0.5389821529388428, -0.3896160125732422, 0.1621669977903366, 0.15579265356063843, -0.13305166363716125, -0.002447812119498849, -0.09822288155555725, -0.44184809923171997, -0.0023773880675435066, 0.2987324893474579, 0.0345461443066597, -0.025111811235547066, 0.3566760718822479, 0.1245688796043396, -0.4685993492603302, 0.6057893633842468, 0.2360837608575821, -0.7904646992683411, 0.4600805342197418, 0.25103068351745605, 0.22850340604782104, 0.18043427169322968, -0.8510902523994446, -0.021588364616036415, 0.2196069061756134, -0.16796763241291046, -0.03799596056342125, 0.3921729326248169, -0.17194274067878723, 0.03179119899868965, 0.1435200423002243, -0.3989278972148895, 0.6513891816139221, 0.42821186780929565, -0.14141710102558136, 0.5909560322761536, 0.06301821023225784, -0.8159778714179993, 0.06499414145946503, 0.357658714056015, -0.04945702478289604, 0.12677468359470367, -0.45615214109420776, 0.35981690883636475, 0.6465426683425903, 0.3627450168132782, -0.09875937551259995, 0.554593563079834, 0.43331724405288696, -0.1970410794019699, 0.3618437349796295, -0.35084787011146545, -0.30580103397369385, 0.500451922416687, 0.5333036184310913, 0.5336875319480896, -0.24917927384376526, 0.18954254686832428, 0.25408872961997986, 0.3077881634235382, 0.17040030658245087, 0.8202288746833801, -0.4934792220592499, 0.5815690159797668, 0.2771534323692322, -0.7705633044242859, 0.13118772208690643, 0.1586351841688156, -0.3047257959842682, -0.5910269618034363, 1.1383295059204102, -0.0514843612909317, -0.24363985657691956, 0.19776254892349243, -0.31419819593429565, 0.8213788866996765, 0.3483397364616394, -0.09145017713308334, 0.29171022772789, 0.4101969599723816, 0.5506243109703064, 0.08619817346334457, 0.12022771686315536, -0.08572295308113098, 0.1452629119157791, 0.7362207174301147, -0.29050275683403015, 0.028224702924489975, 0.07224392890930176, -0.45031946897506714, 0.290492445230484, 0.37134453654289246, 0.008172362111508846, 0.13021649420261383, 0.23852290213108063, 0.35777145624160767, -0.028422007337212563, -0.3082740008831024, 0.009124943055212498, -0.31274038553237915, -0.03647405281662941, 0.1563701629638672, 0.15244393050670624, 0.2540197968482971, 0.07775940001010895, -0.7688939571380615, -0.020595408976078033, 0.11059906333684921, 0.19821347296237946, 0.1355021595954895, -0.353998601436615, 0.5817779302597046, 0.22383663058280945, -0.13094781339168549, 0.056180983781814575, 0.41297847032546997, -0.211077019572258, 0.29905185103416443, -0.5006579756736755, 0.04525476694107056, -0.4284423887729645, -0.3471120297908783, -0.33450716733932495, 0.25948357582092285, 0.904726505279541, 0.27851173281669617, -0.3377571403980255, 0.2030636966228485, -0.014554722234606743, 0.5973417162895203, 0.23403413593769073, -0.2142808437347412, 0.17068986594676971, -0.7814172506332397, -0.00014032375474926084, -0.1133454293012619, 0.46616417169570923, 0.11171716451644897, 0.00798856932669878, -0.1168709546327591, 0.4039497971534729, 0.36406058073043823, -0.3315107524394989, 0.3279440402984619, -0.5250294208526611, 0.03753408044576645, -0.2161969691514969, 0.47930383682250977, -0.4115881621837616, -0.060945864766836166, 0.030641108751296997, -0.10893220454454422, 0.10114715993404388, -0.5228973031044006, 0.2168252021074295, -0.04753977060317993, -0.050947703421115875, 0.28373315930366516, 0.1506214141845703, -0.13811708986759186, -0.3612941801548004, -0.05542318895459175, -0.39370718598365784, 0.005926759447902441, 0.31038743257522583, -0.29179778695106506, 0.14707492291927338, -0.09570301324129105, -0.24926595389842987, -0.025637706741690636, -0.20972149074077606, -0.4650048017501831, -0.49485549330711365, 0.026167595759034157 ]
Invariant natural killer T cells (iNKT cells) are involved in the host defense against microbial infection. Although it is known that iNKT cells recognize glycolipids presented by CD1d, how and where they encounter antigen in vivo remains unclear. Here we used multiphoton microscopy to visualize the dynamics and activation of iNKT cells in lymph nodes. After antigen administration, iNKT cells became confined in a CD1d-dependent manner in close proximity to subcapsular sinus CD169(+) macrophages. These macrophages retained, internalized and presented lipid antigen and were required for iNKT cell activation, cytokine production and population expansion. Thus, CD169(+) macrophages can act as true antigen-presenting cells controlling early iNKT cell activation and favoring the fast initiation of immune responses.
[ -0.016915887594223022, -0.005488026887178421, -0.0017618591664358974, 0.01720854826271534, -0.003341974690556526, 0.023539170622825623, 0.011510176584124565, 0.004199839197099209, -0.013429366052150726, -0.007542482577264309, -0.008580625057220459, 0.009710796177387238, -0.01810811646282673, 0.022253207862377167, -0.0399308055639267, 0.029346071183681488, 0.005756518803536892, -0.0020569460466504097, 0.006835420615971088, -0.006908816285431385, -0.012218314222991467, 0.005616114940494299, 0.010789379477500916, -0.016405653208494186, 0.005434297025203705, 0.01518869400024414, -0.02294950559735298, -0.010507568717002869, -0.028271403163671494, -0.005047720391303301, 0.00085874879732728, 0.015730004757642746, 0.027901601046323776, -0.010096604004502296, -0.010039865039288998, -0.010242514312267303, -0.0069864965043962, 0.020720798522233963, 0.015575051307678223, -0.004325174260884523, 0.025080734863877296, -0.00895886030048132, 0.005059128627181053, 0.008345653302967548, -0.007204454857856035, -0.004856337793171406, -0.0014345613308250904, -0.0017447450663894415, -0.005347708240151405, 0.004806553013622761, -0.011614453978836536, 0.00449714157730341, -0.01218375749886036, 0.01642574742436409, -0.006765378173440695, 0.01692105270922184, 0.01830814592540264, -0.025193991139531136, 0.004085216671228409, 0.011349626816809177, 0.01871383935213089, -0.04853113740682602, 0.013825036585330963, -0.024364136159420013, 0.008733006194233894, -0.06671395152807236, 0.010655802674591541, -0.013042990118265152, 0.005496388301253319, 0.0074838073924183846, 0.0023951083421707153, 0.006832582410424948, 0.007781910710036755, -0.018137678503990173, 0.0011849619913846254, -0.004692517686635256, -0.020815560594201088, 0.028331806883215904, 0.016417626291513443, 0.04279835522174835, -0.006096865516155958, -0.005371809471398592, 0.02607165277004242, 0.012884027324616909, 0.010584813542664051, -0.0032181446440517902, -0.00542196212336421, -0.015569260343909264, -0.006146455183625221, -0.024203279986977577, -0.01705828309059143, -0.03160901367664337, -0.0053794230334460735, 0.004644862376153469, 0.003888834733515978, -0.018819479271769524, -0.01320435106754303, -0.0028682881966233253, 0.016811523586511612, 0.012718915939331055, -0.010204982943832874, 0.031161418184638023, 0.0188242606818676, 0.016735751181840897, -0.010996391996741295, 0.0046991016715765, -0.007554125972092152, -0.0028105047531425953, 0.02634643018245697, 0.012998029589653015, -0.006588249001652002, -0.01338530145585537, 0.008711881935596466, 0.025400763377547264, 0.005236045457422733, 0.01875300332903862, -0.011912268586456776, -0.0044225892052054405, 0.013605168089270592, -0.035674408078193665, 0.005272644571959972, -0.008041232824325562, -0.0064703719690442085, -0.006387811619788408, 0.0022031182888895273, -0.00010459823533892632, -0.01010717824101448, 0.012237991206347942, 0.017283108085393906, -0.0014297037851065397, -0.008382363244891167, -0.003220289945602417, 0.0179878082126379, -0.03527094051241875, -0.006876653991639614, 0.005826537497341633, -0.020197197794914246, -0.004582431633025408, 0.0032350991386920214, -0.00907734502106905, -0.009099539369344711, 0.008841177448630333, 0.0007216606172733009, 0.015243765898048878, 0.026225851848721504, 0.017565013840794563, -0.002493668347597122, -0.005072701722383499, -0.008242369629442692, -0.032042719423770905, -0.01531962025910616, -0.00948474369943142, 0.016389042139053345, -0.007521453313529491, 0.011225157417356968, -0.0043760258704423904, -0.021400228142738342, -0.025159498676657677, -0.006876816041767597, 0.006324442569166422, 0.014377915300428867, -0.029115881770849228, 0.013624770566821098, 0.009360715746879578, 0.024822898209095, -0.00018174806609749794, 0.007331347092986107, 0.000795561820268631, 0.00461801839992404, 0.004583313129842281, -0.009754965081810951, -0.026260338723659515, -0.0014678356237709522, 0.004814508371055126, 0.0024046539328992367, -0.0020977393724024296, 0.021267592906951904, 0.0070626260712742805, -0.013833671808242798, 0.06644856929779053, 0.004838458728045225, -0.016371242702007294, 0.008724593557417393, -0.013638410717248917, 0.00954216904938221, 0.007076506037265062, 0.011904092505574226, -0.0029139756225049496, 0.011919519864022732, 0.024164943024516106, -0.009412312880158424, -0.009800730273127556, -0.016366442665457726, -0.0022046691738069057, -0.020522452890872955, 0.0017705914797261357, 0.025734994560480118, 0.0009282563114538789, 0.013842890039086342, -0.015108032152056694, -0.012480052188038826, -0.005391343031078577, 0.0054091946221888065, -0.005252815783023834, -0.03406890481710434, 0.009082642383873463, -0.015542834997177124, -0.0072344448417425156, -0.022425193339586258, -0.03418288379907608, 0.024503856897354126, 0.0014930223114788532, -0.014932009391486645, -0.006085596978664398, -0.0013995093759149313, 0.02580772526562214, 0.006656375713646412, 0.01395808532834053, -0.017261993139982224, -0.013031909242272377, -0.0008389880531467497, 0.017207525670528412, 0.003356450702995062, 0.002897093305364251, 0.012177519500255585, 0.009788833558559418, -0.005258355289697647, 0.011043703183531761, -0.029079947620630264, -0.0018403816502541304, -0.023366324603557587, 0.007659473922103643, -0.012144140899181366, 0.0050575705245137215, -0.001055210828781128, 0.014335197396576405, 0.01295485906302929, -0.024021610617637634, 0.011148376390337944, -0.010337106883525848, 0.011785706505179405, -0.02655889466404915, 0.03721006587147713, -0.006386056542396545, -0.003251890651881695, 0.00886278972029686, 0.0055748578161001205, 0.023741042241454124, -0.009936682879924774, -0.013152221217751503, 0.01098412461578846, -0.03248627483844757, 0.001282528042793274, -0.04182722419500351, 0.004675591364502907, -0.04029727354645729, 0.02501671575009823, -0.007328149396926165, 0.0271400548517704, -0.0024730178993195295, 0.008932681754231453, 0.0034406844060868025, -0.008180719800293446, 0.0019466567318886518, -0.013394102454185486, 0.014364000409841537, 0.02064422145485878, 0.02956162951886654, 0.008915889076888561, -0.002231718273833394, 0.007803233806043863, 0.0007311219233088195, 0.0010643036803230643, -0.0812239721417427, -0.010635294020175934, -0.01777002215385437, -0.0004925596877001226, 0.009427210316061974, -0.0253971666097641, -0.00011385232210159302, 0.013699926435947418, -0.007994325831532478, 0.017917858436703682, -0.009369593113660812, -0.005756311118602753, -0.0055964174680411816, -0.012447098270058632, -0.018183797597885132, -0.006848898716270924, 0.012791271321475506, -0.009613510221242905, -0.01910996064543724, -0.03393353521823883, 0.02057349681854248, -0.03552703559398651, 0.0277243684977293, -0.011360078118741512, -0.0004649979528039694, 0.022609932348132133, 0.028083069249987602, -0.018308579921722412, -0.018266711384058, 0.006276468746364117, -0.02764751948416233, -0.02664610743522644, -0.014993969351053238, 0.022853702306747437, 0.02267882041633129, -0.008250444196164608, 0.00294249365106225, -0.016950570046901703, -0.02104564756155014, 0.02378658577799797, -0.009406994096934795, 0.016868865117430687, 0.002618734259158373, 0.0036191160324960947, 0.01884407363831997, 0.01429819967597723, 0.014723709784448147, 0.035200294107198715, 0.012630660086870193, -0.0008775675669312477, 0.02366597205400467, 0.01938752830028534, -0.015965282917022705, 0.024054400622844696, -0.0026607064064592123, -0.041347723454236984, -0.022003594785928726, 0.027510996907949448, -0.007885901257395744, -0.004007335286587477, 0.0074477847665548325, -0.040825821459293365, 0.01358046941459179, 0.018391013145446777, -0.001742538996040821, 0.024451501667499542, 0.024156738072633743, 0.009645617567002773, -0.01218306366354227, 0.015187731944024563, -0.005256709177047014, 0.014324775896966457, -0.007830834947526455, -0.008596439845860004, -0.021751554682850838, 0.0031345258466899395, -0.013649099506437778, -0.004522518254816532, -0.03098675049841404, -0.007205318659543991, 0.023863742128014565, 0.028418797999620438, -0.018179267644882202, -0.0412609800696373, 0.007178132422268391, -0.0021359301172196865, 0.011588817462325096, 0.05279635637998581, 0.019788004457950592, -0.014845328405499458, 0.0027881902642548084, 0.0073127057403326035, -0.01395777240395546, 0.00937790609896183, 0.008432789705693722, -0.03460868075489998, -0.004904423840343952, -0.0014413371682167053, 0.0031580845825374126, 0.008999405428767204, -0.02569825015962124, -0.006904766894876957, -0.008249688893556595, -0.013460161164402962, 0.012826332822442055, 0.007698806002736092, 0.009847908280789852, -0.00020215101540088654, -0.005721040070056915, 0.0018860128475353122, 0.00641650753095746, 0.00879129208624363, -0.009893267415463924, 0.021218137815594673, 0.00952829234302044, -0.008403664454817772, 0.004536165855824947, -0.0005124220624566078, 0.07141832262277603, -0.012737962417304516, 0.00820913352072239, -0.018392011523246765, 0.02254512533545494, -0.03749387711286545, -0.0054117226973176, 0.024252889677882195, -0.01584218628704548, -0.017667554318904877, 0.014984824694693089, -0.02343529835343361, -0.001415179343894124, 0.005774186924099922, -0.00036210351390764117, 0.0041156974621117115, -0.00345621001906693, -0.015297489240765572, 0.006621025037020445, -0.02398625761270523, -0.015334118157625198, -0.007643920835107565, 0.005615051370114088, -0.01469446998089552, -0.016289733350276947, -0.0485471710562706, 0.0036730945575982332, -0.01465535257011652, -0.016719326376914978, 0.011167655698955059, -0.008561326190829277, -0.0398731529712677, -0.007335158064961433, 0.010873745195567608, 0.03307322785258293, 0.043604567646980286, 0.01705651916563511, -0.013043458573520184, 0.011157832108438015, -0.015143576078116894, -0.018882760778069496, -0.008140604943037033, 0.01354837417602539, 0.008352192118763924, 0.01541854627430439, 0.008964365348219872, 0.009359164163470268, -0.007511946838349104, -0.02425093576312065, -0.004023241810500622, -0.004798641428351402, 0.018086718395352364, 0.00594455748796463, -0.004654483404010534, 0.002665126696228981, -0.02011287212371826, -0.0007578970398753881, -0.0010403566993772984, -0.013425841927528381, -0.012246565893292427, -0.02378125488758087, -0.01100650429725647, -0.007224639877676964, -0.006941082887351513, 0.016127105802297592, -0.008527292869985104, -0.012274892069399357, -0.00039218529127538204, -0.027443669736385345, -0.044432632625103, -0.003538943827152252, -0.011868977919220924, -0.03185715898871422, 0.014635138213634491, -0.019829902797937393, -0.000017817597836256027, -0.009101202711462975, -0.03833921626210213, 0.026764625683426857, 0.0045233964920043945, -0.005604149308055639, 0.024195164442062378, -0.011095263063907623, -0.019849054515361786, 0.009462188929319382, 0.00961284339427948, -0.013029851019382477, -0.07515281438827515, -0.02044818177819252, -0.027448441833257675, -0.003953239880502224, -0.016667552292346954, 0.00009448034688830376, -0.02530498430132866, 0.034277647733688354, 0.001043500378727913, -0.010519768111407757, -0.023751437664031982, 0.0014686635695397854, 0.022464878857135773, 0.0012197736650705338, 0.012786926701664925, 0.026276547461748123, -0.012454683892428875, -0.014838558621704578, -0.009592436254024506, -0.01841639168560505, -0.01278228685259819, 0.004176332615315914, -0.03331401199102402, 0.015195511281490326, 0.012044863775372505, -0.08041736483573914, -0.004522671923041344, -0.006277937907725573, -0.009676245041191578, -0.0012397626414895058, -0.03544916585087776, 0.005711972247809172, -0.007990003563463688, -0.005599490366876125, -0.015240978449583054, 0.023658737540245056, 0.0071306899189949036, -0.01998376101255417, 0.000432628788985312, -0.006075023673474789, -0.007944515906274319, -0.0030760816298425198, 0.005230106879025698, 0.01574266329407692, -0.018069656565785408, -0.03459470719099045, 0.023528071120381355, -0.010653499513864517, -0.0032965573482215405, -0.0010230198968201876, -0.03277747333049774, -0.0034771892242133617, 0.013518321327865124, -0.02218707650899887, -0.030959084630012512, -0.0036400826647877693, -0.025395024567842484, -0.010112857446074486, -0.009400563314557076, -0.02623455971479416, -0.02532968297600746, 0.001029878156259656, -0.005440431647002697, 0.021729685366153717, -0.002071651630103588, -0.0031068632379174232, 0.005197038874030113, 0.02954954281449318, 0.018894147127866745, -0.012474053539335728, -0.0045681484043598175, 0.007758782245218754, -0.009851026348769665, 0.020388463512063026, 0.004902372136712074, -0.0011843628017231822, -0.031187985092401505, 0.007912416011095047, 0.0024563311599195004, -0.0025249067693948746, 0.019730746746063232, 0.0016634603962302208, -0.0015581297921016812, 0.002545692026615143, 0.017628474161028862, -0.002591298893094063, 0.01266270037740469, -0.003507894929498434, 0.07151611149311066, -0.007073013111948967, 0.008090580813586712, -0.03671181946992874, -0.00641609076410532, 0.006522296462208033, -0.021977603435516357, 0.0026430822908878326, -0.017694052308797836, -0.01953265443444252, 0.011899979785084724, -0.023862488567829132, -0.0026114252395927906, 0.00915448646992445, -0.015766460448503494, 0.006077115889638662, 0.0016328254714608192, 0.006315351463854313, -0.015318017452955246, 0.042424701154232025, 0.019043415784835815, -0.02211245708167553, -0.0425383634865284, -0.02558961883187294, 0.020939690992236137, 0.003789458889514208, 0.012045134790241718, -0.0043162088841199875, -0.0010900015477091074, 0.04193858429789543, -0.00019235082436352968, 0.022655118256807327, -0.002668731613084674, -0.026562225073575974, 0.02267061546444893, 0.02700720727443695, -0.02352803573012352, 0.008593954145908356, 0.002847130876034498, 0.005147965624928474, -0.004110496491193771, 0.015423815697431564, 0.00048375799087807536, 0.01606127992272377, -0.015818636864423752, -0.00881272554397583, -0.00296011078171432, -0.0035887081176042557, -0.00822252407670021, 0.011112505570054054, 0.020599322393536568, -0.005424512550234795, 0.02731216885149479, 0.029374556615948677, -0.0013630203902721405, 0.008021082729101181, -0.011760002002120018, 0.01673506200313568, -0.00727613503113389, 0.006624141708016396, 0.007304971106350422, -0.017093680799007416, 0.021801406517624855, -0.013754362240433693, -0.00003536604344844818, 0.01491206232458353, 0.011518087238073349, -0.025209583342075348, -0.01708771474659443, 0.011644340120255947, -0.012220310978591442, 0.006328507326543331, 0.011702091433107853, 0.003486320376396179, 0.02542363479733467, -0.011390184983611107, 0.021816138178110123, -0.011881772428750992, 0.019628852605819702, 0.010820358991622925, -0.0051087671890854836, -0.013005362823605537, 0.023587552830576897, 0.021428551524877548, -0.014394483529031277, 0.0027537797577679157, 0.007721970789134502, 0.0036535034887492657, 0.0021440736018121243, 0.016248192638158798, 0.012997111305594444, -0.01284059602767229, 0.0018547181971371174, -0.017544042319059372, 0.0026568302419036627, 0.03524963557720184, -0.0006783013232052326, 0.0016231418121606112, -0.0014338078908622265, 0.014603440649807453, -0.0016432336997240782, -0.015560593456029892, -0.020241502672433853, -0.004125025123357773, -0.034131892025470734, 0.0059884293004870415, -0.005341986194252968, 0.01508193276822567, 0.00777705293148756, 0.03487077355384827, 0.0062120333313941956, 0.004410102032124996, 0.0026837862096726894, 0.022037692368030548, -0.024253755807876587, 0.014395507052540779, -0.0025415411219000816, 0.02432948350906372, -0.013275917619466782, -0.013174433261156082, -0.0005156949628144503, 0.0065194983035326, -0.006419991608709097, 0.011915436014533043, 0.0016842804616317153, -0.004960527643561363, -0.010597068816423416, -0.007615366950631142, 0.012893158942461014, 0.011059113778173923, 0.03110312484204769, -0.014442342333495617, 0.009817005135118961, 0.020435798913240433, 0.011614814400672913, 0.02189626172184944, 0.021980255842208862, 0.026383765041828156, 0.0011295783333480358, 0.005441697314381599, 0.009348073042929173, -0.0232025645673275, -0.00024748611031100154, -0.007899085059762001, 0.007832441478967667, -0.0015831133350729942, 0.027884885668754578, -0.0011659928131848574, 0.014155581593513489, 0.015393239445984364, 0.013370495289564133, 0.010137961246073246, -0.009832112118601799, -0.006178511306643486, 0.021231960505247116, 0.01410430483520031, 0.02110135369002819, -0.00012707756832242012, -0.01317536924034357, -0.005611664615571499, 0.005309522617608309, -0.03643792122602463, 0.001526994165033102, -0.01043487899005413, 0.006590372882783413, 0.008108862675726414, 0.002038610866293311, 0.015102562494575977, 0.0022246348671615124, 0.0038306049536913633, -0.006218031980097294, -0.014681576751172543, -0.0008238290902227163, 0.03162207081913948, -0.038401562720537186, -0.002423762809485197, 0.0010957387275993824, -0.006284995935857296, 0.010731818154454231, -0.010963928885757923, 0.014729895628988743, -0.022201579064130783, 0.008615236729383469, -0.006200315430760384, 0.0035248654894530773, -0.04195883125066757, -0.007692624349147081, 0.0060598417185246944, -0.0023855206090956926, 0.010993842966854572, 0.0034332526847720146, -0.014448508620262146, -0.018160495907068253, 0.017997298389673233, 0.011973031796514988, -0.007750842720270157, 0.016439566388726234, -0.016731727868318558, 0.013528553768992424, 0.013243677094578743, -0.004399134777486324, 0.004670797381550074 ]
[ -0.1520804762840271, -0.517942488193512, 0.4381592571735382, 0.12844054400920868, -0.3925478160381317, 0.18500305712223053, 0.1693851202726364, -0.36358290910720825, -0.3667786121368408, -0.3318410813808441, 0.284071147441864, 0.12964312732219696, -0.6955350041389465, 0.07816285640001297, 0.14013366401195526, 0.8213191032409668, -0.33082449436187744, 0.5820626616477966, -0.1660122573375702, -0.6336565017700195, 0.179973766207695, -0.0813787654042244, -0.051158517599105835, -0.2721913456916809, 0.5663411021232605, 0.07028285413980484, 0.13876496255397797, -0.22290213406085968, 0.05351002514362335, 0.03865779563784599, -0.43929874897003174, 0.4043949246406555, -0.4303276538848877, 0.32969164848327637, -0.13853870332241058, 0.45570456981658936, -0.5272272229194641, 0.07720515877008438, 0.05051787942647934, -0.5536825656890869, 0.12461403012275696, -0.43913403153419495, -0.3128220736980438, 0.23624540865421295, -0.3393917679786682, -0.22431662678718567, -1.5635651350021362, 0.463107168674469, 0.18877150118350983, -0.3521462678909302, -0.20377103984355927, 0.06681736558675766, 0.7684759497642517, 0.026507128030061722, 0.12660415470600128, 0.04470732808113098, -0.4780173599720001, -0.11229648441076279, 0.27511048316955566, -0.4448159337043762, 0.30942296981811523, 0.3038192093372345, -0.11163018643856049, 0.15778344869613647, -0.31593310832977295, 1.084423303604126, -0.028484655544161797, 0.23095187544822693, -0.45302966237068176, -0.5635911226272583, 0.07696299999952316, -0.03996942564845085, -0.4065234363079071, 0.49073082208633423, -0.1193041130900383, 0.023993436247110367, -0.1302269697189331, -0.4227869510650635, 0.17208287119865417, 0.8339834213256836, -0.0912616103887558, 0.48869380354881287, 0.36226993799209595, -0.274137020111084, 0.72721928358078, 0.3000211715698242, -0.3632393479347229, 0.6249180436134338, -0.6524631381034851, -0.35171622037887573, 0.09736835211515427, -0.4195033609867096, 0.6045498251914978, 0.2658349573612213, -0.160726860165596, 0.4846855401992798, -0.0572727806866169, -0.1521482765674591, 0.16122661530971527, 0.2939293682575226, -0.3434024453163147, -0.3551834523677826, -0.6315221786499023, -0.4446391761302948, -0.5640735626220703, -0.12226642668247223, -0.49015945196151733, -0.5149169564247131, -0.3761155903339386, 0.16693800687789917, -0.7197209000587463, -0.07096059620380402, -0.3481066823005676, -0.469050794839859, 0.21750403940677643, 0.10718938708305359, 0.17501845955848694, -0.17555762827396393, -0.17737211287021637, 0.6309788227081299, 0.14818282425403595, 0.7220976948738098, -0.018497006967663765, 0.1955956518650055, -0.05364640802145004, -0.2759115993976593, 0.10215076804161072, 0.2709651291370392, -0.2236819565296173, 0.4855487644672394, 0.3135209381580353, 0.9505506753921509, -0.538548469543457, 0.23868632316589355, 0.10378332436084747, 0.11642137169837952, -0.08800425380468369, 0.3991609215736389, -0.11839348077774048, -0.19922930002212524, -0.27893608808517456, 0.1522068828344345, -0.7894583940505981, -0.1192573606967926, 0.15433885157108307, -0.5420518517494202, -0.24858450889587402, 0.5295906066894531, 0.1219358965754509, -0.307110458612442, -0.13959206640720367, -0.012095356360077858, -0.1211509108543396, 0.4118081033229828, -0.30476632714271545, 0.04781129211187363, -0.44884157180786133, 0.06527220457792282, 0.4430542290210724, 0.2448618859052658, -0.40717536211013794, 0.20970436930656433, -0.5679764151573181, 0.12300363183021545, 0.4242483079433441, -0.3620789647102356, 0.26329848170280457, 0.4557957947254181, -0.13582080602645874, -0.3626289665699005, -0.2592465281486511, -0.031383197754621506, 0.016331464052200317, 0.11565711349248886, -0.2389458864927292, 0.021073948591947556, -0.028212368488311768, -0.2670401632785797, 0.2672109007835388, -0.23406776785850525, -0.8857211470603943, -0.259370893239975, 0.13300420343875885, -0.3314570188522339, 0.015458658337593079, 0.16697967052459717, 0.039908215403556824, 0.1322002112865448, 0.21602651476860046, 0.2702849805355072, 0.23863980174064636, 0.2250785231590271, 0.5074570775032043, -0.6787309646606445, 0.903587281703949, -0.10157587379217148, -0.6906824111938477, 1.5644350051879883, 0.15075114369392395, 0.2897888720035553, 0.43705421686172485, -0.06550831347703934, 0.4685409963130951, -0.502185046672821, 0.1620800942182541, 0.2057209461927414, -0.1416463553905487, 0.061689041554927826, -0.33330196142196655, 0.37837255001068115, 0.23393194377422333, 0.1981889307498932, 0.2248508334159851, -0.2640170156955719, 0.22147251665592194, -0.5095700621604919, -0.15539200603961945, -0.10905148833990097, 0.16655637323856354, -0.09441874176263809, 0.48963671922683716, -0.5553505420684814, 0.2951650023460388, 0.49448955059051514, -0.12732386589050293, 0.6974288821220398, 0.543688178062439, 0.15853144228458405, 1.406760334968567, -0.5148012638092041, -0.018154175952076912, -0.825400710105896, -0.04620882123708725, -0.4414810240268707, -0.3851545751094818, 0.2655305862426758, 0.5601637959480286, -0.4960053861141205, 0.5185276865959167, 0.1029544398188591, 0.09592295438051224, 0.43869638442993164, -0.47157856822013855, 0.09482884407043457, 0.3954601585865021, -0.05931879207491875, -0.14938955008983612, 0.5102582573890686, -1.095231056213379, -0.026161689311265945, -0.3760114312171936, 0.47324544191360474, -0.1376948207616806, -0.4514639675617218, 0.32556354999542236, 0.1954837292432785, -0.5375432968139648, -0.2817326784133911, 0.33539485931396484, -0.06565362960100174, 0.23286780714988708, -0.010153112933039665, -0.2914508581161499, 0.1198892667889595, -0.22463227808475494, -0.6506330966949463, -0.8829169273376465, -0.03964497521519661, 0.8058803677558899, 0.36701518297195435, 0.6998539566993713, 0.17393724620342255, -0.3280787765979767, 0.14548377692699432, -0.34956324100494385, -0.3986435532569885, 0.2673424780368805, 0.8425198793411255, -0.7056078314781189, -0.5434573292732239, 0.0028004529885947704, -0.09584016352891922, 0.9007723331451416, 0.06950733810663223, -0.23077960312366486, -0.4896962642669678, -0.17989668250083923, -0.54642653465271, -0.798833966255188, -0.6281318664550781, -0.2162168174982071, 0.5096287727355957, -0.3099634647369385, -0.22642678022384644, -0.017202237620949745, 0.17662005126476288, -0.3010050058364868, 0.224568709731102, 0.6307787299156189, 0.11089237779378891, -0.34240004420280457, 0.46197453141212463, 0.08435693383216858, -0.5309333205223083, 0.008334345184266567, 0.07449522614479065, -0.21740014851093292, 0.20819644629955292, -5.733391284942627, 0.5235456824302673, -0.10795033723115921, 0.21611006557941437, -0.3089306950569153, -0.14172089099884033, 0.8836112022399902, 0.4141029119491577, 0.12701217830181122, 0.37128734588623047, 0.1872849464416504, 0.34654098749160767, -0.1959105283021927, -0.06537996977567673, -0.3042133152484894, 0.37389108538627625, 0.5751320123672485, 0.22750389575958252, -0.012490976601839066, 0.31476178765296936, -0.5353096127510071, 0.1822441816329956, -0.016643084585666656, 0.7551887035369873, 0.23404476046562195, -0.20771996676921844, -0.79099041223526, 0.318390429019928, -0.11535529047250748, -0.39971527457237244, -0.11206013709306717, -0.35961538553237915, 0.047055650502443314, -0.13830773532390594, 0.36647146940231323, 0.21593211591243744, 0.42941614985466003, 0.015810571610927582, -0.43600863218307495, -0.8253574371337891, 0.029496658593416214, 0.28919968008995056, -0.40603503584861755, -0.39105790853500366, 0.2626110017299652, -0.16931945085525513, -0.452001690864563, 0.02609349600970745, -0.6485961675643921, 0.36049726605415344, -0.152574822306633, -0.5732075572013855, -0.17068776488304138, 0.4227863848209381, 0.6475250124931335, 0.2873982787132263, -0.0013431513216346502, 0.13280119001865387, -0.6780248284339905, 0.4274054169654846, 0.10758697241544724, -0.15002603828907013, -0.3827369213104248, -0.5728481411933899, -0.06351397931575775, 0.07277035713195801, -0.6827261447906494, -0.24307824671268463, 0.5024287700653076, 0.09866645187139511, -0.3442915380001068, 0.005328772123903036, 0.193020299077034, -0.5357314348220825, 0.35508543252944946, -0.5895513892173767, 0.49656927585601807, -0.12533536553382874, -0.03662930801510811, 0.0516400970518589, -0.2150454819202423, -0.08479401469230652, -0.26194652915000916, 0.537257969379425, -0.3604375422000885, 0.08579854667186737, 0.6851473450660706, 0.07503284513950348, -0.24034562706947327, 0.5146535038948059, 0.43389418721199036, 0.3958539664745331, -0.26161590218544006, 0.3740791380405426, -0.27383068203926086, -0.23283331096172333, 0.2982664704322815, 0.08975278586149216, 0.027665726840496063, -0.24541577696800232, 1.0906175374984741, -0.34055107831954956, -0.1262131929397583, -0.6782605051994324, 0.5712642669677734, 0.7217177748680115, -0.4258511960506439, -0.02010718174278736, 1.20548677444458, -0.32945528626441956, -0.10344360768795013, 0.20886893570423126, 0.13176746666431427, -0.022969050332903862, 0.5502182245254517, -0.18821896612644196, 0.2988319396972656, -0.058720432221889496, 0.677700936794281, -0.564563512802124, 0.18809394538402557, 0.5154929161071777, -0.4757716953754425, 0.06147770583629608, -0.41815441846847534, -0.15225519239902496, 0.315037339925766, 0.5305034518241882, -0.5421562790870667, -0.1338321417570114, 0.39826756715774536, 0.37705349922180176, -0.4501291811466217, 0.050405390560626984, -0.05787673965096474, -0.3347102999687195, -0.02429833821952343, -0.29554158449172974, 0.7216785550117493, -0.36090049147605896, 0.4286213517189026, -0.22743216156959534, -0.13056308031082153, -0.22959381341934204, 0.26950642466545105, 0.10841108113527298, 0.35185325145721436, -0.07705508917570114, -0.7773586511611938, -0.06332746148109436, 0.8624756336212158, -0.3276544213294983, -0.019747164100408554, -0.11507736891508102, -0.14759939908981323, 0.45057204365730286, 0.6623835563659668, -0.22708755731582642, 0.9202716946601868, -0.2797044813632965, 0.32247644662857056, 0.5880311727523804, -0.4637383222579956, -0.27638065814971924, 0.09602133929729462, -0.6019518375396729, -0.2101990431547165, -0.5069461464881897, 0.014699622057378292, -0.00851344969123602, -0.07610108703374863, -0.3306189477443695, -0.307178258895874, -0.0984940379858017, -0.054942961782217026, -0.20613878965377808, -0.6150184273719788, 0.10078940540552139, -0.5657660365104675, 0.364939421415329, 0.18754704296588898, -0.23265570402145386, -0.20124264061450958, -0.10687185823917389, 0.4878622889518738, 0.0319131501019001, 0.32360169291496277, -0.1700621396303177, -0.45687136054039, -0.024654000997543335, 0.5477045774459839, 0.5223274827003479, 0.2908352017402649, -0.05513238534331322, 0.2035033106803894, 0.1624230146408081, 0.1207839697599411, 0.8254554867744446, -0.2170916497707367, -0.28760385513305664, -0.051659658551216125, 0.6155679225921631, -0.6883003115653992, 0.567406177520752, -0.31074249744415283, 0.12612144649028778, -0.1029106080532074, -0.16124668717384338, 0.09997031092643738, -0.5313888788223267, -0.23286721110343933, -0.7556781768798828, -0.08503321558237076, 0.20382189750671387, -0.0452766977250576, 0.16407574713230133, -0.1462637186050415, -0.7527763843536377, -0.40843430161476135, 0.5603131651878357, -0.2716407775878906, -0.08482266962528229, 0.36675313115119934, 0.18529333174228668, 0.3746774196624756, -0.21847419440746307, 0.38128381967544556, -0.6544422507286072, 0.15541593730449677, 0.451242059469223, 0.3270445466041565, -0.10899238288402557, -0.11656813323497772, 0.33248454332351685, -0.7970380187034607, -0.3065597116947174, -0.41947513818740845, -0.0880952849984169, 0.08793173730373383, 0.21527116000652313, 0.31759658455848694, 0.6852482557296753, -0.7407144904136658, -0.5154935717582703, 0.4756900370121002, 0.2939542233943939, 0.06560669094324112, -0.2122492790222168, -0.3367050886154175, 0.3435613512992859, -0.016150375828146935, -0.04544183984398842, 0.3269418478012085, -0.10707034915685654, 1.0647969245910645, -0.13932828605175018, 0.34732726216316223, -0.17556537687778473, 0.1858636736869812, -0.004071865696460009, 0.07593411952257156, 0.04910799860954285, -0.3009035885334015, -0.20916779339313507, -0.6990997195243835, 0.21504057943820953, -0.3802765905857086, -0.62917560338974, 0.45197850465774536, -0.61274254322052, -0.13775576651096344, 0.24404415488243103, 0.8403875827789307, 0.2883644104003906, 0.052793920040130615, -0.1942845582962036, -0.0885758325457573, 0.33327215909957886, -0.0014898738591000438, 0.170780211687088, -0.27263519167900085, -0.5608174800872803, 0.019468318670988083, -0.6282683610916138, 0.2650032639503479, -0.74810391664505, 0.2546212077140808, -0.11982923001050949, -0.3621622920036316, -0.435249000787735, -0.10768744349479675, 0.2204899936914444, -0.1894516497850418, -0.3323863744735718, -0.11261412501335144, 0.4213864803314209, -0.037868931889534, 0.01233943272382021, 0.04814257472753525, -0.19470587372779846, -1.168293833732605, 0.38405951857566833, 0.191324844956398, -0.027522999793291092, -0.23687028884887695, -0.13258853554725647, 0.5068972110748291, 0.15498244762420654, -0.4136165976524353, 0.031547661870718, 0.047442417591810226, -0.028149619698524475, 0.687447726726532, -0.048383258283138275, -0.5322591662406921, 0.09451068937778473, 0.13489799201488495, -0.03184834122657776, 0.24341006577014923, 0.2848975658416748, 0.20543314516544342, 0.3085085153579712, 0.03716067224740982, 0.1191612184047699, -0.2946896255016327, 0.3373149335384369, 0.06344236433506012, 0.6535183787345886, -0.24754531681537628, 0.48082324862480164, 0.4235270917415619, 0.36645838618278503, -0.2544177770614624, 0.2828175723552704, 0.6036167740821838, 0.6965122222900391, 0.3943765163421631, -0.36549097299575806, -0.41717565059661865, 0.3000156879425049, 0.7450370788574219, 0.70302414894104, -0.1854185163974762, -0.5759077668190002, -0.28943362832069397, -0.15951962769031525, -0.31700682640075684, 0.2420630156993866, 0.0195492971688509, 0.19400061666965485, 0.5071659684181213, -0.13552764058113098, -0.36410218477249146, -0.09785415977239609, -0.5800179243087769, 0.0035465003456920385, 0.47278162837028503, -0.972055196762085, -1.2366595268249512, -0.039099354296922684, -0.49133390188217163, 0.23526357114315033, 0.45289865136146545, 0.34619036316871643, -0.6170106530189514, -0.0035200940910726786, 0.6194635629653931, -0.21070866286754608, 0.13186736404895782, -0.052597664296627045, 0.2305014431476593, 0.049001775681972504, -0.01290060393512249, 0.5496030449867249, 0.10250918567180634, -0.4703596532344818, 0.46014052629470825, 0.19859552383422852, -0.12564337253570557, 0.29602423310279846, 0.17529158294200897, 0.5403850078582764, -0.015925012528896332, -1.2267016172409058, -0.13274869322776794, -0.277452290058136, -0.11544736474752426, -0.3745933473110199, 0.3215228021144867, 0.25761935114860535, 0.03800642490386963, -0.4623415768146515, 0.14677202701568604, 0.29500624537467957, -0.07925721257925034, 0.27188393473625183, -0.52545565366745, 0.7139554023742676, 0.39635583758354187, 0.29942014813423157, -0.2301798015832901, 0.4193543791770935, -0.35946935415267944, 0.06395603716373444, -0.3071182370185852, 0.4498245418071747, -0.6978661417961121, 0.04027421027421951, -0.40238744020462036, -0.25522202253341675, 1.0220918655395508, 0.45438820123672485, -0.24886582791805267, 0.09602917730808258, 0.11967965215444565, -0.04221193119883537, 0.9418922066688538, -0.2158581018447876, -0.2584797143936157, -0.38447338342666626, -0.47040027379989624, -0.5207214951515198, 0.459669291973114, -0.0313977487385273, -0.24974046647548676, -0.2594166100025177, 0.22251884639263153, 0.5519393682479858, -0.35268667340278625, 0.32262665033340454, -0.7243329882621765, -0.34865453839302063, -0.7926498055458069, 0.552993893623352, -0.6929407715797424, 0.47684404253959656, -0.776779055595398, 0.5217896103858948, 0.43700215220451355, 0.01078034844249487, 0.4750988483428955, 0.11006119847297668, 0.3452938199043274, 0.0538792721927166, 0.4575592279434204, 0.6511860489845276, -0.13091188669204712, -0.13461950421333313, -0.2879776358604431, 0.08957843482494354, -0.2907961905002594, -0.35712698101997375, 0.061867695301771164, -0.20050370693206787, -0.29593074321746826, 0.36362090706825256, -0.08966143429279327, -0.5865434408187866, -0.5901408791542053, 0.2676510512828827 ]
Cells deficient in a major DNA double-strand break repair pathway (nonhomologous DNA end joining [NHEJ]) have increased spontaneous chromosome breaks; however, the source of these chromosome breaks has remained undefined. Here, we show that the observed spontaneous chromosome breaks are partially suppressed by reducing the cellular oxygen tension. Conversely, elevating the level of reactive oxygen species by overexpressing the antioxidant enzyme superoxide dismutase 1 (SOD1), in a transgenic mouse, increases chromosome breakage. The effect of SOD1 can also be modulated by cellular oxygen tension. The elevated chromosome breakage correlates histologically with a significant increase in the amount of neuronal cell death in Ku86(-/-) SOD1 transgenic embryos over that seen in Ku86(-/-) embryos. Therefore, oxygen metabolism is a major source of the genomic instability observed in NHEJ-deficient cells and, presumably, in all cells.
[ 0.002452574437484145, 0.005595228634774685, -0.012082470580935478, 0.013839367777109146, 0.006513041909784079, -0.02893044799566269, 0.008790574036538601, -0.0007186946459114552, -0.011164264753460884, -0.019430674612522125, -0.002050379291176796, 0.01144905760884285, -0.013602880761027336, 0.0049272626638412476, 0.010130494832992554, 0.036395616829395294, -0.017876580357551575, -0.0010791504755616188, 0.0061881523579359055, 0.008783860132098198, -0.016377704218029976, -0.011761698871850967, 0.009891023859381676, -0.02736843191087246, 0.014958915300667286, 0.00047879701014608145, 0.023311328142881393, 0.008876334875822067, -0.0012608077377080917, -0.0031693805940449238, -0.010155851021409035, 0.01152932457625866, 0.00836476031690836, -0.006720906123518944, 0.01234961487352848, 0.007426276803016663, 0.0007509173010475934, 0.02152809500694275, 0.0350201390683651, -0.003920599352568388, -0.012424945831298828, -0.014552092179656029, 0.00946691632270813, -0.028408672660589218, -0.010265459306538105, -0.0037688929587602615, -0.003259032964706421, 0.0008159875869750977, 0.02191765233874321, 0.00576681736856699, -0.006257186643779278, 0.001583519158884883, -0.015522846952080727, 0.0261587705463171, -0.0054727839305996895, -0.00955567229539156, 0.017693746834993362, 0.024745121598243713, -0.019920770078897476, -0.024445846676826477, 0.01330431830137968, 0.007618752308189869, -0.01586894318461418, 0.005783453118056059, 0.004177124705165625, -0.0672391802072525, 0.012241233140230179, -0.006684270687401295, 0.007502355612814426, -0.0007974333129823208, -0.001395111670717597, 0.007610200438648462, -0.003237568773329258, 0.0030679136980324984, -0.008556350134313107, -0.015069874003529549, -0.01830320991575718, 0.007204982452094555, -0.017579343169927597, 0.013639426790177822, -0.017841143533587456, -0.025789279490709305, 0.005544060841202736, 0.013935551047325134, -0.01360372919589281, -0.0036783688701689243, -0.01930384710431099, 0.0066719092428684235, -0.002951717469841242, -0.008695839904248714, 0.006472220178693533, -0.015177051536738873, -0.0012666245456784964, 0.022726738825440407, 0.006404493004083633, -0.014928877353668213, -0.010343005880713463, -0.03843957185745239, 0.01254622358828783, -0.008844532072544098, -0.020611517131328583, 0.020534630864858627, 0.011026567779481411, -0.0045433659106493, -0.005590193904936314, 0.004391505382955074, 0.031178785488009453, -0.005378710106015205, 0.013697957620024681, 0.004247103817760944, 0.004459752235561609, 0.019276075065135956, 0.012117795646190643, 0.020709026604890823, 0.03189947083592415, 0.012938660569489002, -0.03322230279445648, 0.015906885266304016, 0.007496544159948826, 0.011464308947324753, 0.021654950454831123, -0.013919624499976635, -0.005999199580401182, 0.007553645875304937, 0.0023481864482164383, 0.02169499546289444, 0.004053737968206406, -0.009848913177847862, 0.004721415229141712, -0.001341034658253193, -0.0066958339884877205, 0.005787480156868696, -0.027783900499343872, 0.0019006328657269478, -0.007946787402033806, -0.0017636767588555813, -0.024160224944353104, -0.02338244765996933, -0.001264274469576776, -0.007029267959296703, 0.008613879792392254, 0.009747999720275402, -0.007932931184768677, 0.013149568811058998, 0.020137472078204155, -0.00252451840788126, 0.009576907381415367, -0.005822390783578157, 0.00761673878878355, -0.005851764231920242, -0.005747213028371334, -0.017575165256857872, -0.011905993334949017, -0.012912958860397339, 0.008445505052804947, 0.008573420345783234, -0.032222677022218704, -0.0008143717423081398, -0.00002252508420497179, 0.028187545016407967, -0.04111489653587341, 0.001990085933357477, 0.002579190069809556, 0.009170157834887505, 0.015482574701309204, 0.010560363531112671, -0.008531775325536728, -0.006494786590337753, 0.012142542749643326, 0.004981556907296181, -0.005950577557086945, 0.0012148960959166288, -0.023720338940620422, 0.009848862886428833, 0.011695802211761475, 0.004028787836432457, 0.014375945553183556, 0.00567353330552578, -0.001366844167932868, 0.06730834394693375, -0.01724102720618248, 0.035301268100738525, -0.00547573110088706, -0.006060048937797546, 0.01362745463848114, 0.000048942165449261665, 0.021460648626089096, -0.005907166283577681, -0.008769147098064423, 0.023191872984170914, 0.011179852299392223, 0.010864867828786373, 0.0009976993314921856, 0.000015560071915388107, -0.028759442269802094, 0.0026219114661216736, 0.017558882012963295, -0.0014822710072621703, -0.00507954228669405, 0.017005864530801773, 0.02364509180188179, 0.006297705695033073, 0.009673690423369408, -0.018754437565803528, 0.016872834414243698, 0.008478622883558273, -0.009368294849991798, 0.007292602676898241, -0.011603271588683128, -0.002499994356185198, 0.008306012488901615, 0.0006510280072689056, 0.004015797283500433, -0.009530526585876942, -0.012713352218270302, -0.011481105349957943, -0.0018645671661943197, 0.036064065992832184, -0.034892916679382324, -0.013143328949809074, 0.00850001722574234, -0.0025125506799668074, -0.0004976773634552956, -0.017287176102399826, 0.01957133412361145, -0.016787230968475342, -0.008291134610772133, 0.008360277861356735, -0.026687655597925186, 0.012474769726395607, -0.007876098155975342, -0.01543037686496973, -0.009696228429675102, 0.02223842218518257, 0.0026972028426826, -0.008064361289143562, 0.013589451089501381, -0.007482845336198807, 0.013802962377667427, -0.008686086162924767, 0.006579434033483267, 0.00870443694293499, 0.03467097505927086, -0.004963146522641182, 0.01401347853243351, 0.0021990840323269367, 0.018369704484939575, 0.021173851564526558, 0.05390950292348862, -0.007377131842076778, 0.005425523035228252, -0.020391542464494705, -0.009765837341547012, -0.014397906139492989, 0.012441901490092278, -0.020090730860829353, 0.0015236509498208761, 0.013026914559304714, 0.023272186517715454, -0.0035589169710874557, -0.000034132273867726326, 0.006312128156423569, 0.026769977062940598, -0.01829967275261879, -0.012414837256073952, 0.005919212009757757, 0.016995318233966827, -0.002489123959094286, 0.030279237776994705, -0.007401762064546347, 0.006451777182519436, -0.0027688718400895596, -0.0033166902139782906, -0.08167237043380737, -0.014352640137076378, -0.020225854590535164, -0.018870806321501732, 0.009052610024809837, 0.013795861974358559, -0.008074801415205002, 0.0020644529722630978, -0.007411595433950424, 0.015424472279846668, 0.025763098150491714, -0.0027432951610535383, -0.0044930120930075645, -0.017678946256637573, -0.015468640252947807, -0.012459074147045612, 0.0069447290152311325, -0.013066209852695465, -0.017061827704310417, -0.025569992139935493, -0.0040090037509799, -0.022935811430215836, -0.011457942426204681, 0.017044248059391975, -0.0055159917101264, -0.020507099106907845, 0.008730013854801655, 0.002844664268195629, -0.015604167245328426, 0.0005467873997986317, -0.01862117275595665, -0.008382583037018776, 0.007773356046527624, -0.009851169772446156, -0.013274461030960083, 0.03600156307220459, -0.021529020741581917, 0.013274658471345901, -0.02163069322705269, 0.02050124853849411, 0.017934348434209824, 0.0006129192188382149, 0.012851659208536148, 0.018463462591171265, -0.00634362967684865, -0.007673813030123711, 0.01702488213777542, 0.028183046728372574, 0.012219238094985485, 0.011196393519639969, -0.004006028175354004, 0.001795588992536068, 0.014217006042599678, 0.007358723320066929, -0.005502862855792046, -0.014236733317375183, -0.025961097329854965, -0.0002487329766154289, -0.009824082255363464, -0.008267891593277454, -0.010702276602387428, 0.0034401516895741224, 0.004915071185678244, 0.0208425410091877, 0.012277945876121521, 0.0039795562624931335, 0.016470830887556076, 0.007502415683120489, -0.01286831684410572, 0.02159673161804676, -0.01097127702087164, -0.010422119870781898, -0.014189593493938446, -0.00840995367616415, -0.0010761446319520473, -0.012016823515295982, -0.01229503471404314, -0.0068768830969929695, 0.011595087125897408, -0.008019058965146542, -0.04219086095690727, -0.0037379234563559294, -0.01824977621436119, -0.005323572084307671, -0.0317264162003994, -0.024094488471746445, 0.004759960807859898, 0.029995378106832504, 0.01738627441227436, -0.014414969831705093, 0.008503172546625137, 0.027353189885616302, 0.03925976902246475, 0.01307552121579647, -0.0019187391735613346, -0.0003137656021863222, -0.00773975346237421, -0.017506714910268784, 0.004779432900249958, 0.008268563076853752, -0.039667703211307526, 0.0007104362011887133, 0.02260141260921955, -0.004126355983316898, 0.012188943102955818, 0.012074990198016167, -0.0014479474630206823, -0.007590310648083687, 0.014207444153726101, 0.0014516172232106328, -0.021538518369197845, 0.004778904374688864, -0.005510113667696714, 0.008263413794338703, 0.0006970149697735906, -0.004151417873799801, -0.009505474008619785, 0.019919265061616898, 0.07301116734743118, -0.01995992287993431, 0.013406707905232906, -0.002399467397481203, -0.008588702417910099, -0.0027938950806856155, -0.006591391749680042, 0.0027724842075258493, 0.007958825677633286, -0.024123214185237885, 0.011020531877875328, 0.005495726130902767, -0.020469771698117256, -0.015383133664727211, -0.023515179753303528, 0.009017029777169228, -0.027425870299339294, -0.00018295831978321075, -0.005493496544659138, -0.00855276733636856, -0.029431724920868874, -0.01802358590066433, 0.0009529723320156336, 0.0005495750810950994, -0.003715978469699621, -0.017802322283387184, 0.00038872030563652515, -0.013526663184165955, -0.004809423815459013, 0.010453196242451668, 0.019259851425886154, 0.00479706609621644, -0.0033121835440397263, 0.006629403680562973, 0.0029254169203341007, 0.008133923634886742, 0.0096675930544734, -0.003561644349247217, -0.008921823464334011, 0.0009981675539165735, 0.004583617672324181, -0.01298150047659874, 0.017132021486759186, 0.012304520234465599, 0.02820848673582077, 0.007476375438272953, 0.04962805286049843, -0.0060934629291296005, 0.013971105217933655, 0.010681582614779472, 0.004386460408568382, 0.002250330988317728, 0.005131745245307684, 0.015046038664877415, -0.00040207430720329285, -0.023887397721409798, 0.007268616929650307, -0.006228473037481308, 0.012760890647768974, 0.005752553232014179, 0.0005824191030114889, 0.0011252521071583033, 0.028572630137205124, -0.015495290979743004, -0.008556898683309555, -0.006153996102511883, -0.008317259140312672, -0.006626075133681297, -0.008944298140704632, -0.0230461023747921, -0.002485598437488079, 0.01561657339334488, -0.004375657998025417, 0.002249411540105939, -0.021605471149086952, 0.013573506847023964, 0.013447705656290054, 0.02966833859682083, 0.017926441505551338, -0.040529780089855194, -0.02014457806944847, 0.008241062052547932, 0.000588730676099658, 0.027435198426246643, 0.021481972187757492, -0.028073571622371674, -0.03624625876545906, -0.075279600918293, -0.007957440800964832, -0.007153022103011608, -0.004892752971500158, -0.0011540339328348637, -0.011530342511832714, -0.0001296041300520301, 0.017244385555386543, -0.0003291359171271324, -0.004435661248862743, 0.0049820877611637115, -0.02037130668759346, 0.007109048776328564, -0.035346031188964844, 0.010751569643616676, 0.0007528867572546005, 0.012455799616873264, 0.013833370059728622, -0.012795699760317802, 0.017895247787237167, 0.0024830373004078865, 0.00323868403211236, 0.026326647028326988, 0.004272547550499439, -0.006669885013252497, -0.08179443329572678, -0.02680480107665062, 0.011465433984994888, -0.004829558543860912, -0.01569262519478798, 0.007808587979525328, -0.006150732282549143, 0.007072389125823975, -0.0037689730525016785, -0.009299935773015022, 0.015889374539256096, 0.008842546492815018, 0.011416698805987835, 0.00040606025140732527, 0.006066850386559963, -0.004187733866274357, 0.005636213347315788, 0.006349352188408375, -0.0052346158772706985, 0.046686843037605286, 0.007316084578633308, 0.012315691448748112, -0.009066459722816944, 0.00004264956805855036, -0.009443271905183792, -0.0034426948986947536, -0.011325228959321976, 0.004941902123391628, 0.015511837787926197, -0.0001071481965482235, 0.00988586712628603, -0.010196237824857235, -0.008785862475633621, -0.028991935774683952, 0.022850101813673973, -0.011249657720327377, -0.013058116659522057, -0.008494095876812935, -0.031245537102222443, 0.00724809942767024, -0.004440715070813894, -0.001878197188489139, 0.008675782009959221, 0.009564445354044437, -0.012496951967477798, -0.02055473066866398, 0.00465667899698019, -0.011012330651283264, 0.004778777714818716, 0.005105259828269482, 0.007874018512666225, 0.00338192330673337, -0.0017179208807647228, 0.0009476263076066971, -0.025053048506379128, -0.019710440188646317, -0.005128414370119572, 0.019695205613970757, 0.018413079902529716, -0.010043122805655003, 0.0003516065771691501, 0.005682650487869978, -0.002749337814748287, 0.0719885379076004, -0.018152788281440735, 0.011987974867224693, -0.019249143078923225, 0.01654309220612049, 0.0017600073479115963, 0.0030253827571868896, 0.001560842152684927, -0.005347241181880236, -0.015216988511383533, 0.010330147109925747, -0.006385453976690769, -0.003531795460730791, 0.010938332416117191, 0.03230790048837662, -0.013484959490597248, 0.025888750329613686, 0.017718806862831116, -0.015450363978743553, 0.0059683904983103275, -0.007766433991491795, 0.02855410799384117, -0.009161621332168579, 0.01790018379688263, 0.001083996845409274, -0.007111817132681608, -0.012756550684571266, -0.00831974484026432, 0.0015753284096717834, 0.030219994485378265, 0.0026298891752958298, -0.03335630148649216, -0.0005584543105214834, -0.018198378384113312, 0.013041513040661812, 0.013260935433208942, 0.028323311358690262, 0.0035446914844214916, -0.03553379327058792, 0.013639918528497219, -0.02604205347597599, 0.013054417446255684, -0.001268650172278285, -0.007870091125369072, 0.010255787521600723, -0.002834281185641885, -0.010574504733085632, 0.016803530976176262, 0.014704772271215916, 0.009001614525914192, 0.01915334165096283, 0.0073807756416499615, 0.00656208535656333, -0.018484752625226974, 0.01832353137433529, -0.002048294525593519, -0.02047736756503582, 0.015585244633257389, -0.01742038130760193, 0.0056501999497413635, -0.00798969529569149, -0.016080038622021675, -0.0069440798833966255, -0.015733040869235992, 0.013717216439545155, -0.03431112319231033, -0.004011988639831543, -0.007237007841467857, 0.012813749723136425, 0.010998742654919624, 0.005733751691877842, -0.009640997275710106, 0.004434575792402029, -0.007924942299723625, 0.011108191683888435, 0.006800789386034012, 0.0153804961591959, 0.015877312049269676, 0.02274923026561737, 0.015562978573143482, -0.011852780357003212, 0.038124457001686096, -0.016765324398875237, -0.005600695498287678, 0.007404854521155357, -0.025819111615419388, -0.002444732468575239, -0.006173406261950731, -0.00011220556916669011, 0.008845691569149494, 0.010249359533190727, 0.0003920473391190171, 0.0019285152666270733, 0.02655734494328499, 0.003913695923984051, 0.033579565584659576, 0.020677659660577774, 0.0012626085663214326, -0.007798016536980867, 0.012675633653998375, 0.02151256613433361, 0.004287221468985081, -0.009974493645131588, -0.01728401519358158, 0.006712984759360552, 0.004707427229732275, 0.01585870049893856, 0.020918671041727066, 0.005928623490035534, -0.009530252777040005, -0.0030360189266502857, -0.004136272240430117, 0.01719849742949009, -0.008596505038440228, 0.0033408179879188538, 0.0032332539558410645, -0.015768814831972122, 0.025121811777353287, 0.01171666756272316, -0.007775204721838236, 0.0007966842968016863, 0.006228598766028881, -0.01709795743227005, -0.006680625956505537, 0.0013804268091917038, -0.016558120027184486, -0.009598445147275925, -0.013708416372537613, 0.005376230925321579, -0.020109768956899643, 0.004880226217210293, -0.023765550926327705, -0.011477830819785595, -0.004990117624402046, -0.003203399246558547, -0.00016591278836131096, 0.008084561675786972, 0.0070657916367053986, -0.008720260113477707, 0.015792742371559143, 0.004641605541110039, -0.0005620094016194344, -0.00010536960326135159, 0.007151322439312935, 0.007043365854769945, -0.028897445648908615, 0.014420758001506329, -0.005762324668467045, 0.010350212454795837, 0.0010852157138288021, -0.0018199605401605368, 0.012543254531919956, 0.001214759424328804, -0.0054450384341180325, 0.02183518372476101, 0.0124851418659091, 0.00998556986451149, -0.025777265429496765, -0.00003127031959593296, 0.0034521224442869425, 0.018494881689548492, 0.04273281991481781, -0.016023410484194756, -0.0015557660954073071, 0.00125113595277071, -0.003301100106909871, 0.01712731644511223, 0.01920402981340885, -0.019886843860149384, 0.00973140262067318, 0.021934863179922104, -0.006144009064882994, -0.014651224948465824, -0.003392321290448308, -0.014486407861113548, -0.005864020437002182, 0.005408875644207001, -0.015427526086568832, 0.01995040662586689, 0.011859112419188023, 0.00853551272302866, 0.009729074314236641, -0.0013415394350886345, -0.0013893498107790947, -0.01566288247704506, -0.016473140567541122, 0.003545379498973489, -0.0010670027695596218, 0.005495867691934109, -0.0012849739287048578, 0.0017403396777808666, -0.0018040479626506567, -0.003365719225257635, -0.0159749798476696, -0.004323978908360004, -0.0324038527905941, -0.0026771933771669865, -0.019947387278079987, 0.015039991587400436, 0.003880126401782036, 0.022433102130889893, -0.00694388709962368 ]
[ 0.21808864176273346, -0.054221756756305695, -0.3923451602458954, 0.09516260772943497, 0.008333839476108551, -0.3050735592842102, 0.42648741602897644, 0.04300294071435928, -0.09761547297239304, -0.4417789578437805, 0.03079371340572834, 0.016038892790675163, -0.5686688423156738, -0.11664401739835739, -0.1983136236667633, 0.5372156500816345, 1.1047114133834839, 0.45831963419914246, -0.4575040638446808, -0.5388323068618774, -0.21116423606872559, -0.32825374603271484, 0.4939146935939789, 0.08815181255340576, -0.014562527649104595, -0.5882445573806763, 0.4819776713848114, -0.07816951721906662, 0.350909948348999, -0.12097182124853134, -0.2883482575416565, 0.5677549839019775, 0.42907026410102844, -0.04234384372830391, -0.22427913546562195, 0.20556879043579102, -0.3849669098854065, -0.3476667106151581, 0.12741589546203613, 0.16935165226459503, -0.2275468409061432, -0.4720853567123413, 0.1951718032360077, 0.5443055629730225, -0.1958707720041275, 0.04115952178835869, -1.3021752834320068, 0.9427607655525208, 0.40787243843078613, 0.15733285248279572, -0.0002611282397992909, 0.3567233383655548, 0.1550041139125824, 0.39666107296943665, 0.5259208679199219, -0.1367790699005127, -0.7447896003723145, 0.08814547955989838, 0.5333627462387085, -0.5015314221382141, -0.04661431536078453, -0.023159034550189972, -0.6904320120811462, 0.10067017376422882, -0.22676467895507812, 0.6385030746459961, 0.08108103275299072, -0.3144487142562866, -0.6890615224838257, -0.40827685594558716, 0.30115219950675964, -0.3771289587020874, -0.03853290155529976, 0.1489924192428589, 0.1361861526966095, -0.15800192952156067, -0.46353939175605774, -0.5488690733909607, 0.20034416019916534, -0.056688226759433746, 0.18064220249652863, 0.3612983524799347, 0.3074796199798584, 0.054224785417318344, 0.5165764093399048, 0.1557336300611496, 0.15096546709537506, 0.8333594799041748, -0.43461573123931885, -0.330584317445755, 0.1393538862466812, 0.3117472231388092, 0.6007033586502075, 0.24083112180233002, 0.02740745060145855, 0.6942040920257568, 0.42599114775657654, -0.2860109806060791, 0.056835245341062546, 0.33001595735549927, -0.09962956607341766, -0.03851631283760071, 0.3044583797454834, -0.2594102621078491, -0.5108309984207153, -0.5440465807914734, 0.26510098576545715, -0.26075825095176697, -0.303417444229126, 0.23398131132125854, -0.7357431650161743, 0.11881113052368164, -0.4783424437046051, -0.2751298248767853, -0.10024190694093704, 0.14922860264778137, -0.07383900135755539, -0.006386331282556057, -0.17293521761894226, 0.013627100735902786, -0.3141895830631256, 1.3381904363632202, -0.18023686110973358, 0.6062708497047424, -0.18709847331047058, -0.12917830049991608, 0.35991400480270386, 0.2142612636089325, 0.1032913327217102, 0.5159928798675537, 0.10486697405576706, 0.9989874958992004, -0.35054683685302734, -0.07749053835868835, 0.3393842279911041, 0.025567438453435898, 0.5282135605812073, 0.31904342770576477, 0.17607681453227997, -0.018665475770831108, -0.7143306136131287, -0.4871751368045807, 0.2976177930831909, 0.1838996708393097, 0.05928501486778259, -0.33136823773384094, -0.18053582310676575, -0.03082043118774891, 0.14364969730377197, -0.3302457630634308, 0.27772632241249084, -0.24130959808826447, -0.9255090355873108, 0.06618887931108475, 0.13183991611003876, 0.37556904554367065, -0.3633100688457489, -0.41617551445961, -0.32268816232681274, 0.25775885581970215, -0.004953319672495127, -0.26284581422805786, -0.1014518216252327, -0.17867833375930786, 0.3778904974460602, 0.05413235351443291, 0.4627876877784729, 0.7902072072029114, -0.26170268654823303, 0.059145208448171616, -0.23732417821884155, -0.17682012915611267, 0.025853356346488, -0.7877839803695679, 0.2316739708185196, 0.25548720359802246, 0.05996572971343994, 0.00766042061150074, -0.018285928294062614, 0.289052277803421, -0.9715350270271301, 0.2087816745042801, 0.41698187589645386, -0.07315609604120255, 0.2926020324230194, 0.11215950548648834, 0.4773154854774475, -0.027409886941313744, -0.12889744341373444, 0.009875667281448841, -0.0461321622133255, -0.26613831520080566, 0.8099369406700134, -0.5500571131706238, 1.6170421838760376, -0.14716306328773499, -0.2885896861553192, 0.6854342222213745, 0.12107884883880615, -0.0399225577712059, -0.22010941803455353, 0.022188475355505943, 0.7017695903778076, -0.25706949830055237, -0.45927175879478455, 0.24451304972171783, -0.031694769859313965, -0.20857299864292145, 0.057658806443214417, 0.011965688318014145, 0.34072238206863403, -0.5446028113365173, 0.2919008731842041, 0.20388107001781464, -0.002660113386809826, -0.33315375447273254, -0.4133889973163605, -0.5429122447967529, -0.4763689339160919, -0.30756181478500366, 0.014078156091272831, -0.13681660592556, 0.445574015378952, 1.0476981401443481, 0.10144640505313873, 0.7793506979942322, 0.8131083250045776, 0.2853963077068329, 0.8584083318710327, -0.09363405406475067, 0.09229373186826706, -0.38659200072288513, -0.07258664816617966, -0.20631282031536102, -0.07571939378976822, 0.420437216758728, 0.6352004408836365, 0.11095388978719711, 0.3398045599460602, -0.15054310858249664, -0.08104311674833298, 0.4163702726364136, -0.7102867364883423, -0.20998981595039368, -0.015299314633011818, -0.021050825715065002, 0.0401342436671257, 0.3978591561317444, -1.3159204721450806, -0.2838927209377289, 0.08122675865888596, 0.14320683479309082, 0.13870106637477875, -0.6177138090133667, -0.11980447173118591, -0.06952198594808578, 0.06302227079868317, -0.2699183225631714, 0.07314988970756531, -0.6455679535865784, -0.3865327835083008, -0.20596998929977417, 0.21046769618988037, 0.18894341588020325, -0.09595991671085358, -0.1945694088935852, -0.8786497116088867, -0.3249797224998474, 1.1795991659164429, 0.4353560507297516, 0.5469915866851807, -0.009269626811146736, -0.7246605753898621, 0.07971026003360748, -0.40886372327804565, -0.26979219913482666, -0.21838156878948212, 0.6743999719619751, -0.40531259775161743, 0.030568040907382965, -0.09177280962467194, 0.5569635629653931, 0.8177891969680786, -0.3618675172328949, -0.4176981449127197, 0.14459864795207977, -0.02963586337864399, -0.6553386449813843, -0.24649247527122498, -0.6657664179801941, -0.12907516956329346, 0.3961612284183502, -0.05213215947151184, 0.03167514130473137, 0.5873511433601379, -0.0005632051615975797, 0.11904463171958923, 0.23641455173492432, 0.5819306373596191, 0.27133020758628845, 0.05766235664486885, -0.03166140243411064, 0.008947433903813362, -0.258556067943573, -0.5535566806793213, 0.4851219952106476, -0.38393840193748474, 0.21904481947422028, -5.769704341888428, 0.30131056904792786, -0.010472689755260944, 0.15916240215301514, -0.22865597903728485, -0.2966550588607788, 0.8411081433296204, 0.23287194967269897, 0.08759668469429016, 0.08991236239671707, 0.10888161510229111, 0.30011433362960815, -0.27206942439079285, -0.14190709590911865, -0.6216970682144165, -0.46497413516044617, 0.19891297817230225, -0.6690971851348877, 0.6560845971107483, 0.24933883547782898, 0.06943190842866898, 0.03928491473197937, 0.2582971453666687, 0.2984367609024048, 0.06742139160633087, 0.06435690820217133, -0.5502079129219055, -0.1886240541934967, -0.29286670684814453, -0.7081113457679749, -0.19785110652446747, -0.5257394909858704, 0.1571761965751648, -0.30316781997680664, 0.437239408493042, 0.38687771558761597, 0.0712943896651268, -0.04708818346261978, -0.3976960778236389, -0.17217640578746796, 0.2413494884967804, -0.08079466968774796, -0.3300415575504303, -0.1385616511106491, 0.31365564465522766, 0.17112043499946594, 0.15247842669487, -0.061009641736745834, -0.22074075043201447, 0.9003387093544006, -0.14017020165920258, -0.23289448022842407, 0.4930746555328369, 0.34943774342536926, 0.2816533148288727, 0.41269510984420776, -0.12320774048566818, 0.028949446976184845, -0.1254483461380005, -0.18556813895702362, -0.4995993971824646, -0.042877212166786194, -0.3722802400588989, -0.34903040528297424, 0.3068055212497711, 0.32100966572761536, -0.24331746995449066, -0.22138604521751404, 0.5052987337112427, -0.16776318848133087, 0.028429873287677765, 0.31939709186553955, 0.9288202524185181, -0.8837211728096008, 0.6690542697906494, -0.6085386872291565, -0.06670675426721573, -0.026187365874648094, 0.040316205471754074, 0.17451003193855286, -0.40418896079063416, -0.30795836448669434, -0.10767432302236557, -0.2772531509399414, 0.20041579008102417, -0.6471894979476929, -0.0402374193072319, 0.25182124972343445, -0.1926487535238266, 0.3735515773296356, 0.6884371042251587, -0.05548565462231636, 0.08151784539222717, 0.33997002243995667, 0.34933435916900635, 0.38984787464141846, 0.37003442645072937, 0.7655505537986755, 0.2786230742931366, 0.10161478817462921, 0.4557898938655853, 0.15291979908943176, -0.4827995002269745, -0.8582881093025208, -0.4596690237522125, 0.2785133123397827, -0.8847776055335999, 0.37038710713386536, 0.3485100567340851, -0.9200024008750916, 0.1675662398338318, -0.19366930425167084, -0.8395987749099731, -0.25544384121894836, 0.9861268401145935, -0.03962627425789833, 0.21146801114082336, 0.11477183550596237, 0.9649983644485474, -0.1757667064666748, 0.4297330379486084, 0.3991456627845764, -0.6395620703697205, -0.17803512513637543, 0.020911507308483124, 0.011314591392874718, -0.14150460064411163, 0.7593210935592651, -0.506393551826477, -0.28110212087631226, 0.30770644545555115, 0.6519894599914551, -0.48321518301963806, 0.1575256586074829, 0.11218659579753876, -0.4922102689743042, -0.40415820479393005, 0.5998921990394592, -0.05074366554617882, -0.24970266222953796, 0.390688955783844, -0.42779356241226196, -0.05071285367012024, -0.17228926718235016, 0.20487911999225616, 0.07101324945688248, -0.17473377287387848, -0.3344379663467407, -0.1786319762468338, -0.14664116501808167, 0.17198039591312408, -0.3524806499481201, 0.013697151094675064, 0.0774630755186081, -0.25007057189941406, 0.3045607805252075, 0.3265380859375, -0.004625196568667889, 0.18244898319244385, -0.5577178597450256, 0.19590795040130615, 0.11966805905103683, -0.6269218921661377, -0.26777392625808716, -0.35756295919418335, -0.38849958777427673, -0.09734024107456207, -0.701255738735199, -0.4090627133846283, -0.01620454341173172, -0.5972238183021545, -0.2663514018058777, -0.1970672309398651, 0.16082948446273804, 0.3687950372695923, -0.5080894231796265, -0.260731965303421, -0.10603129118680954, 0.3981550633907318, -0.1578843742609024, 0.08513104170560837, -0.4113714098930359, -0.032333794981241226, 0.06518208235502243, 0.8251848220825195, 0.09643473476171494, 0.0955083966255188, -0.03378736600279808, -0.17946621775627136, -0.2129785269498825, 0.3514508306980133, 0.017489857971668243, 0.06336068361997604, -0.09078986942768097, 0.08010529726743698, 0.1237657442688942, 0.09482522308826447, 0.7071661353111267, 0.09448865056037903, -0.3497442305088043, 0.2511007785797119, -0.03428952023386955, -0.5670183897018433, 0.007976256310939789, 0.5238752961158752, 0.10735242813825607, -0.35749924182891846, 0.34679701924324036, -0.4057040214538574, -0.551624059677124, -0.2136380672454834, -0.9614224433898926, -0.37068548798561096, -0.22273115813732147, -0.13257461786270142, -0.10963863134384155, 0.1431056708097458, -0.3061853349208832, -0.48695793747901917, 0.23692812025547028, 0.15049231052398682, -0.142347052693367, 0.03904514014720917, -0.1815178245306015, -0.4070453345775604, -0.5975732207298279, 0.398351788520813, -0.6564558148384094, 0.3545723259449005, -0.0638568252325058, 0.038036759942770004, -0.17370082437992096, 0.197992205619812, -0.059739850461483, -0.2043033391237259, -0.34634310007095337, -0.2492949515581131, 0.19258686900138855, -0.7137614488601685, 0.41070544719696045, 0.5379090309143066, 0.47682690620422363, -0.5073015689849854, 0.02795911207795143, -0.2962927520275116, 0.28368696570396423, 0.05980478599667549, -0.6540798544883728, -0.2157900035381317, -0.021237723529338837, 0.4673609435558319, -0.08383196592330933, 0.24465329945087433, 0.5912198424339294, 0.8502762317657471, 0.04156345874071121, 0.271826833486557, -0.8273793458938599, -0.02416398748755455, 0.12586769461631775, -0.35487180948257446, 0.11230861395597458, 0.34465986490249634, 0.4430406391620636, 0.0757722482085228, -0.08749600499868393, -0.20390242338180542, -0.729781985282898, 0.7106294631958008, -0.06921572238206863, -0.00492378743365407, -0.17528170347213745, 0.6359339952468872, 0.33100026845932007, -0.22364002466201782, 0.3159325420856476, -0.477209210395813, 0.10605321079492569, -0.32503780722618103, 0.32268211245536804, -0.03049953654408455, -0.6415489912033081, 0.5681006908416748, -0.4787341356277466, 0.281307578086853, -0.5985130071640015, 0.4584071934223175, -0.8961306214332581, -0.031661346554756165, -0.1386188566684723, -0.29839903116226196, -0.06701253354549408, -0.5996221303939819, -0.5014382004737854, 0.38648882508277893, 0.07312661409378052, -0.09611935168504715, -0.05992293357849121, 0.06389397382736206, -0.27340754866600037, -0.4829528033733368, 0.4296979606151581, 0.2336384803056717, -0.26378709077835083, -0.17443051934242249, 0.46487510204315186, 0.22367170453071594, -0.08768752962350845, -0.7188169956207275, -0.12848928570747375, 0.19124451279640198, -0.11558881402015686, 0.06864184141159058, 0.03363751247525215, -0.269454687833786, 0.25713232159614563, -0.07985639572143555, -0.05833450332283974, -0.12990225851535797, 0.2823241651058197, 0.6138032674789429, 0.32054510712623596, 0.1098744347691536, -0.15109661221504211, -0.2990330457687378, 0.24294796586036682, 0.37325793504714966, -0.22353295981884003, 0.47144052386283875, 0.967904806137085, 0.40492895245552063, 0.5752774477005005, -0.17206662893295288, 0.837818443775177, 0.6892600655555725, -0.07618051767349243, 0.166452556848526, -0.1601133644580841, -0.23817139863967896, -0.042852386832237244, 0.5018227100372314, 0.10549727827310562, -0.2706545293331146, 0.10905076563358307, 0.5466911792755127, 0.25808092951774597, -0.1565178632736206, -0.07262640446424484, -0.2497888207435608, 0.12310758978128433, 0.44728919863700867, -0.6745225787162781, -0.5517160296440125, 0.5224177837371826, -0.7129836082458496, 0.023152131587266922, 0.37847113609313965, -0.6821789741516113, -0.3803054988384247, 0.1411394625902176, -0.3795003592967987, -0.029088662937283516, -0.36286231875419617, 0.5801497101783752, 0.26139211654663086, 0.1142883151769638, 0.43766024708747864, 0.39052748680114746, 0.2019304782152176, -0.5400112867355347, 0.1814778596162796, -0.3351001441478729, 0.16682244837284088, -0.09829646348953247, 0.2957870066165924, -0.24051783978939056, 0.46060895919799805, -0.020640525966882706, -0.023132095113396645, 0.3934580683708191, -0.7322666049003601, 0.21713155508041382, -0.37879690527915955, -0.5698465704917908, -0.10463592410087585, -0.18265093863010406, -0.1996690034866333, -0.23721562325954437, -0.2316998541355133, 0.264617919921875, 0.32954567670822144, -0.8113930821418762, -0.029254088178277016, 0.1876966506242752, -0.0069587090983986855, -0.08405113965272903, 0.03333505988121033, 0.1962611824274063, 0.31655871868133545, 0.26548269391059875, 0.25699859857559204, 0.0596638023853302, -0.12883563339710236, 0.45991113781929016, -1.2155267000198364, 0.7495473027229309, -0.7652533054351807, -0.41147691011428833, -0.5865213871002197, -0.10473299771547318, 1.2097283601760864, 0.9531022906303406, -0.17227527499198914, 0.3702290952205658, 0.297471821308136, 0.5638977885246277, 0.2594701647758484, -0.5716364979743958, -0.2941022515296936, -0.6882072687149048, 0.18018530309200287, -0.45091429352760315, 0.8134046792984009, -0.327615886926651, -0.20283329486846924, 0.024446288123726845, 0.42378494143486023, 0.1943541169166565, -0.15516898036003113, 0.45303210616111755, -0.6678807139396667, 0.3613126873970032, -0.2923835217952728, 0.4087226688861847, -0.6272556185722351, 0.4936368465423584, -0.1808602511882782, -0.2181074619293213, -0.3590066432952881, -0.3954394459724426, 0.15029220283031464, -0.12322808057069778, -0.3139156699180603, 0.13093329966068268, 0.18112564086914062, -0.23254673182964325, -0.17851397395133972, -0.7718954086303711, -0.07077649235725403, 0.14547301828861237, 0.246888667345047, -0.103016696870327, 0.054007358849048615, -0.07308773696422577, 0.21710877120494843, -0.0700201466679573, 0.08304224163293839, -0.20349439978599548, 0.06680155545473099, -0.003228246932849288 ]
PURPOSE OF REVIEW Recent preclinical and clinical studies revealed that the semirandom insertion of transgenes into chromosomal DNA of hematopoietic cells may induce clonal competition, which potentially may even trigger leukemia or sarcoma. Insertional mutagenesis caused by gene vectors has thus led to major uncertainty among those developing advanced hematopoietic cell therapies. This review summarizes novel studies of underlying mechanisms; these studies have demonstrated the possibility of improved gene vector biosafety and generated new insights into stem cell biology. RECENT FINDINGS The characteristic insertion pattern of various retroviral gene vector systems may be explained by properties of the viral integrase and associated cellular cofactors. Cell culture assays and animal models, including disease-specific and cancer-prone mouse models, are emerging that reveal the contributions of vector features and systemic factors to induction of clonal imbalance. Databases summarizing vector insertion sites in dominant hematopoietic clones are evolving as new tools to identify genes that regulate clonal homeostasis. SUMMARY Mechanistic studies of insertional mutagenesis by random gene vector insertion will lead to improved tools for advanced hematopoietic cell therapy. Simultaneously, fascinating insights into gene networks that regulate cell fitness will be generated, with important consequences for the fields of hematology, oncology and regenerative medicine.
[ -0.006053261924535036, 0.009611405432224274, 0.0037023606710135937, 0.03427446633577347, 0.028171101585030556, -0.004060053266584873, 0.009127561002969742, 0.014052070677280426, -0.014895781874656677, 0.0022447961382567883, -0.007665998302400112, 0.008826296776533127, -0.005469505675137043, 0.011093934997916222, -0.019567061215639114, -0.012611732818186283, -0.023740002885460854, -0.011733375489711761, 0.007522709667682648, -0.011558601632714272, -0.007925309240818024, -0.008801184594631195, 0.009954890236258507, -0.010967118665575981, -0.019728315994143486, 0.011901980265974998, -0.027899274602532387, -0.007250267546623945, -0.01690460927784443, -0.04188879579305649, -0.011885850690305233, -0.002182521391659975, 0.014196998439729214, 0.0023635798133909702, 0.0014554187655448914, 0.01982676424086094, 0.0021781332325190306, 0.015546530485153198, 0.03330736607313156, -0.005171980243176222, 0.009106230922043324, -0.009438744746148586, 0.0008130981586873531, -0.018148837611079216, -0.009929278865456581, -0.01024601049721241, -0.0024816980585455894, 0.012146396562457085, 0.011833644472062588, 0.0069226487539708614, -0.010976442135870457, -0.006137038581073284, -0.004871760029345751, 0.019824054092168808, -0.006076267920434475, -0.019237810745835304, 0.01883769780397415, -0.00130115554202348, 0.02021830715239048, 0.022077903151512146, -0.006164519116282463, -0.0227788295596838, 0.0010971208103001118, 0.017011113464832306, 0.008326099254190922, -0.06695210188627243, 0.017779327929019928, 0.01881079375743866, 0.011426374316215515, 0.03374374285340309, 0.0019628298468887806, 0.004729247651994228, 0.012100303545594215, -0.0012659309431910515, 0.017416423186659813, -0.01291461382061243, -0.01109757088124752, -0.00027639325708150864, 0.040049776434898376, 0.01855524256825447, -0.00010592490434646606, -0.015012156218290329, 0.010960081592202187, 0.0035948988515883684, 0.02027004398405552, 0.0016378627624362707, -0.020717928186058998, -0.004541338421404362, 0.022273899987339973, -0.03483354300260544, 0.008675934746861458, 0.02012547105550766, -0.022661713883280754, 0.00011361530050635338, -0.02870573103427887, -0.010627557523548603, -0.01270635612308979, -0.06303934752941132, 0.014417867176234722, -0.01689290627837181, -0.007462734822183847, 0.006024233065545559, 0.01706884056329727, -0.01221876498311758, -0.0001872633583843708, 0.010263572447001934, 0.007383463904261589, 0.020520443096756935, 0.011245899833738804, 0.010403638705611229, -0.0023575276136398315, 0.016804160550236702, 0.015177158638834953, 0.01564866676926613, 0.009475165978074074, 0.00033092033118009567, 0.012595807202160358, 0.00004507182165980339, 0.015605037100613117, -0.0067044878378510475, 0.011352865025401115, -0.011229567229747772, -0.002532368525862694, 0.034300848841667175, 0.004334199242293835, 0.003349343314766884, -0.021573320031166077, -0.00929432176053524, 0.02652515098452568, 0.011300938203930855, -0.00848395749926567, 0.0011371336877346039, 0.0026940922252833843, -0.013874052092432976, -0.004810376092791557, -0.0009864338207989931, -0.025289585813879967, 0.011523623019456863, 0.0012165200896561146, -0.00883619487285614, 0.0076880669221282005, 0.005768149625509977, -0.006618180312216282, 0.011716451495885849, -0.0035858647897839546, -0.001766354776918888, 0.020946990698575974, -0.002726567443460226, 0.007569248788058758, 0.00303907273337245, 0.007039139047265053, 0.01785893365740776, -0.026034165173768997, -0.018322555348277092, -0.005625903140753508, 0.0199546180665493, -0.020342011004686356, -0.02326432801783085, -0.008099738508462906, 0.030514970421791077, -0.010273491963744164, -0.02451641857624054, 0.007017538882791996, 0.009307559579610825, -0.0072743091732263565, 0.006858887616544962, -0.0184924378991127, -0.0022936537861824036, -0.001825207844376564, 0.0032910052686929703, -0.0024446258321404457, 0.009969482198357582, 0.01141892559826374, 0.012208322063088417, -0.002135584596544504, 0.0009819758124649525, 0.03903520479798317, 0.005326098762452602, -0.016060370951890945, 0.06617090851068497, 0.0069750226102769375, 0.013489313423633575, -0.020022636279463768, -0.007994537241756916, 0.014003334566950798, -0.007284794468432665, -0.009047574363648891, -0.002771798986941576, -0.02983100712299347, -0.010231357999145985, -0.0011928942985832691, 0.003263357561081648, -0.01909952238202095, 0.012811578810214996, -0.015573237091302872, 0.002403212245553732, 0.01538836769759655, -0.0012724201660603285, -0.008539367467164993, 0.02900604158639908, -0.00530408276244998, -0.0012883527670055628, 0.02167639508843422, -0.023727502673864365, -0.021151786670088768, 0.005272223614156246, 0.008820747956633568, -0.021623263135552406, 0.009439784102141857, -0.003291062079370022, 0.023571709170937538, 0.024530727416276932, -0.014400436542928219, 0.0010762291494756937, -0.010819660499691963, 0.009868497028946877, 0.004319998435676098, 0.024394754320383072, -0.007280983962118626, -0.010252358391880989, 0.0027828807942569256, 0.015346483327448368, 0.024615010246634483, -0.016700245440006256, 0.024420231580734253, 0.007873043417930603, 0.009448954835534096, 0.011699540540575981, 0.0025410205125808716, -0.009502336382865906, -0.013148477301001549, -0.024562528356909752, -0.011010031215846539, 0.03236177936196327, 0.0016320906579494476, 0.007411058992147446, 0.012702642939984798, -0.022734850645065308, 0.014290137216448784, -0.013854535296559334, -0.0036534303799271584, 0.0022546101827174425, 0.05937163531780243, -0.02033766731619835, 0.004261179361492395, 0.003712940728291869, 0.010889885947108269, 0.029257796704769135, 0.012200701981782913, -0.02980414777994156, 0.007921514101326466, -0.01606610231101513, 0.020573025569319725, -0.021280454471707344, -0.017865296453237534, 0.01442992314696312, 0.0040581184439361095, 0.010812126100063324, 0.025297880172729492, -0.015367337502539158, 0.01123112067580223, 0.0059456732124090195, 0.021279681473970413, -0.018447425216436386, -0.020350532606244087, -0.02176516130566597, 0.02433600276708603, 0.015801962465047836, 0.030742397531867027, 0.005334159359335899, 0.006819983944296837, 0.003298373194411397, -0.0016349677462130785, -0.08145751059055328, -0.010755542665719986, 0.007685115560889244, 0.00928700901567936, 0.010515347123146057, 0.023857273161411285, 0.007212725467979908, 0.004760141484439373, -0.006852832622826099, -0.0015367392916232347, -0.0023239203728735447, 0.021906500682234764, -0.003316344926133752, 0.018056504428386688, -0.021232783794403076, -0.009319331496953964, 0.008915286511182785, -0.013691553846001625, -0.011011213064193726, -0.009237338788807392, -0.001129276119172573, -0.032045211642980576, -0.0068482812494039536, 0.019787367433309555, -0.021585406735539436, 0.026847926899790764, -0.0009850207716226578, 0.014067674055695534, -0.0068076676689088345, 0.004007802810519934, -0.005085784941911697, -0.01377333328127861, 0.007479818072170019, -0.009537679143249989, -0.01634391024708748, 0.0234580896794796, -0.006148485466837883, 0.0061209481209516525, -0.013287696987390518, 0.030432090163230896, -0.02285967394709587, 0.003919645212590694, 0.029295723885297775, 0.0021754184272140265, 0.007531740237027407, 0.00018512574024498463, 0.005820450838655233, 0.00592984352260828, 0.015311464667320251, 0.00904680322855711, 0.02220991998910904, 0.011498432606458664, -0.012840768322348595, 0.01203417032957077, -0.016960661858320236, -0.018933188170194626, -0.018327202647924423, 0.005095703061670065, -0.009447617456316948, -0.010423042811453342, 0.0022973516024649143, -0.0006948551163077354, 0.004472332075238228, -0.011381050571799278, 0.020164785906672478, 0.0035455217584967613, 0.014878680929541588, 0.002388032153248787, -0.00979998055845499, 0.011319434270262718, 0.016934026032686234, -0.011604984290897846, 0.02137957699596882, -0.0008808046113699675, -0.022216394543647766, -0.0028135620523244143, -0.01526064332574606, -0.006993108429014683, 0.017347164452075958, 0.00983921904116869, -0.009595740586519241, 0.005185045301914215, -0.03521706536412239, -0.009068348444998264, -0.013199012726545334, 0.0066370889544487, 0.003863323014229536, 0.041516222059726715, 0.014143707230687141, -0.014948533847928047, 0.011578516103327274, 0.020774368196725845, 0.01936957985162735, 0.007770616095513105, 0.0006809914484620094, -0.007094535510987043, 0.004197201691567898, 0.008157126605510712, 0.02168712019920349, 0.008044236339628696, -0.016621481627225876, 0.008403263986110687, 0.018577110022306442, -0.0061234780587255955, -0.018443753942847252, 0.01416761800646782, 0.005491083487868309, -0.009023420512676239, -0.00206941831856966, -0.0035641135182231665, -0.014082072302699089, -0.022384852170944214, -0.001639293972402811, -0.004699338227510452, 0.009973175823688507, 0.0020029395818710327, 0.0010881689377129078, -0.009417681023478508, 0.07256723195314407, -0.0008802558295428753, -0.007199685089290142, -0.018067361786961555, -0.016950426623225212, -0.009231760166585445, -0.0003140685148537159, -0.009261338040232658, -0.02584080770611763, -0.015004176646471024, 0.012593388557434082, -0.0227486751973629, -0.0022482993081212044, -0.0007377676665782928, -0.018480785191059113, -0.002543736482039094, -0.00945773534476757, 0.011152117513120174, 0.0008449703454971313, -0.017260178923606873, -0.011251688003540039, -0.011913962662220001, -0.015180585905909538, 0.010225126519799232, -0.00003292923793196678, -0.0109011922031641, -0.023814495652914047, -0.010191410779953003, -0.02559191733598709, 0.006060935091227293, 0.038288429379463196, 0.0026780839543789625, -0.003502632724121213, -0.003360942006111145, -0.008014160208404064, 0.005859473720192909, 0.02337181195616722, 0.021048303693532944, -0.016252614557743073, 0.011368575505912304, -0.015045437961816788, -0.009836564771831036, -0.0009748013690114021, 0.015264187939465046, 0.012003812938928604, 0.00221999641507864, 0.0341196246445179, -0.005769226234406233, -0.0027595460414886475, -0.014300255104899406, -0.01661342941224575, -0.013054436072707176, 0.015910129994153976, 0.010202345438301563, -0.0014571538195014, -0.011986316181719303, 0.004408212378621101, -0.0019973989110440016, 0.02778518944978714, -0.0017068255692720413, -0.018357062712311745, -0.031080156564712524, 0.022568967193365097, -0.020897410809993744, 0.013747996650636196, -0.008601639419794083, -0.024127377197146416, -0.0024321735836565495, -0.012168386951088905, -0.012685952708125114, 0.012009283527731895, 0.0006102873012423515, -0.015413958579301834, -0.019745681434869766, -0.014950277283787727, 0.00728940311819315, -0.004738659597933292, -0.0022725453600287437, 0.0068580335937440395, -0.002260399516671896, 0.007292505353689194, 0.003978645894676447, -0.019772524014115334, 0.009850001893937588, 0.015900302678346634, 0.0013214820064604282, -0.023876041173934937, -0.07556343823671341, -0.010531413368880749, -0.008846349082887173, -0.007654289249330759, 0.006254933774471283, -0.0021473451051861048, -0.018541913479566574, 0.021080952137708664, 0.016183027997612953, -0.00764799490571022, 0.011714291758835316, -0.02759464830160141, 0.001070612110197544, -0.007650434505194426, 0.00941989291459322, 0.029411882162094116, -0.005158750806003809, -0.011089682579040527, -0.04907115548849106, -0.02000076323747635, 0.005171943921595812, 0.006853488273918629, -0.005980534479022026, 0.009919770993292332, -0.002011076547205448, -0.08124888688325882, 0.0020407051779329777, -0.025067634880542755, -0.00725078210234642, -0.010466218926012516, -0.016934840008616447, -0.007244064472615719, -0.0060768723487854, -0.0027347151190042496, -0.014544193632900715, -0.01829143986105919, 0.0049500903114676476, 0.0009698264766484499, -0.006148150190711021, -0.0031204712577164173, -0.005773419048637152, 0.00016138365026563406, -0.003020722419023514, -0.006922710686922073, 0.009418975561857224, -0.002871270291507244, -0.016362305730581284, -0.005797784775495529, -0.015640178695321083, -0.013190291821956635, -0.04722778499126434, -0.006107610650360584, 0.010465017519891262, -0.008877006359398365, 0.023102834820747375, 0.005170096643269062, -0.027501672506332397, -0.013332998380064964, -0.018909860402345657, 0.001971258083358407, -0.01564165949821472, 0.00446850573644042, 0.0004017651081085205, 0.0029464182443916798, 0.008883940055966377, -0.007045288570225239, 0.007845185697078705, 0.009780270978808403, 0.00815261248499155, -0.008243952877819538, 0.001900872215628624, 0.006793429143726826, -0.0069070723839104176, 0.007530820555984974, 0.0007355194538831711, 0.011837203055620193, -0.0014275377616286278, -0.03148356080055237, 0.0042127203196287155, -0.02166726253926754, 0.0020661363378167152, -0.004152270965278149, 0.006688759662210941, 0.001090057659894228, 0.0035683908499777317, -0.00292633892968297, 0.002558656968176365, -0.020497066900134087, 0.07106813788414001, -0.0169996190816164, -0.005937871057540178, -0.02046280913054943, -0.014701562002301216, 0.0044547454454004765, -0.03481239825487137, -0.007187787909060717, -0.019221993163228035, -0.008045590482652187, 0.026842180639505386, -0.0056602004915475845, 0.004266693256795406, 0.010578146204352379, 0.012697497382760048, -0.00596484262496233, -0.005725042428821325, 0.01414894126355648, -0.012527578510344028, 0.0042453040368855, 0.007756731938570738, 0.0016791196539998055, -0.026511508971452713, 0.006243478506803513, -0.0054657235741615295, -0.001849926309660077, -0.05167156830430031, -0.0060494402423501015, -0.018160894513130188, 0.005248725414276123, -0.0007568886503577232, 0.0036637037992477417, -0.0008294769213534892, 0.014819948934018612, 0.0034825713373720646, 0.01397827360779047, -0.014271938242018223, -0.001688856747932732, -0.015889089554548264, -0.02484486624598503, -0.021562593057751656, 0.011172846890985966, 0.0006911195814609528, 0.015517208725214005, 0.0008279094472527504, 0.0062393080443143845, -0.003822515718638897, 0.016930900514125824, -0.00017043529078364372, 0.013187527656555176, 0.032094139605760574, 0.006142559926956892, 0.008521612733602524, -0.0032239342108368874, 0.02747807651758194, 0.001687563955783844, 0.014896133914589882, 0.021923329681158066, -0.011243121698498726, -0.0006508959922939539, 0.027744000777602196, -0.008278541266918182, -0.03321400284767151, -0.026561304926872253, 0.019392628222703934, -0.028947845101356506, 0.01662064716219902, -0.022821299731731415, -0.0037485011853277683, 0.012528080493211746, 0.01728435978293419, 0.011128894984722137, 0.0070036472752690315, -0.01120160985738039, 0.025572311133146286, 0.02114824578166008, 0.012945488095283508, 0.013263043016195297, 0.010100191459059715, 0.021116061136126518, -0.007261511869728565, -0.00485983956605196, 0.011275429278612137, 0.01630491018295288, -0.023730408400297165, -0.012027179822325706, 0.013667079620063305, 0.01484702154994011, 0.00037281596451066434, 0.010914552956819534, 0.028821414336562157, -0.0045660994946956635, -0.004935223609209061, 0.028356675058603287, 0.006299015134572983, 0.034991487860679626, 0.005378111265599728, 0.0007047662511467934, -0.01456354558467865, 0.016235429793596268, 0.010183770209550858, -0.008882695809006691, -0.017460353672504425, -0.03050806187093258, -0.03559857979416847, -0.0026971313636749983, 0.013063376769423485, 0.012139227241277695, -0.001234468538314104, 0.0009588026441633701, -0.0022325431928038597, 0.012652336619794369, 0.030423887073993683, -0.015000008046627045, 0.0036315058823674917, 0.004777972120791674, -0.01425552275031805, -0.0021304814144968987, -0.0034970156848430634, -0.01490017306059599, -0.0320885144174099, -0.00026760553009808064, -0.030066434293985367, 0.029165228828787804, 0.004398200660943985, -0.010719030164182186, -0.010638205334544182, 0.019222764298319817, -0.03298790380358696, 0.0008188240462914109, 0.007984369993209839, -0.03176041319966316, -0.019716188311576843, 0.008987139910459518, 0.005731090437620878, -0.007138286717236042, -0.0003103609196841717, -0.010021022520959377, -0.016470855101943016, 0.04700088873505592, 0.027509555220603943, 0.008663089945912361, -0.0018300202209502459, 0.012499353848397732, 0.010001052170991898, 0.0007858993485569954, 0.01513688638806343, -0.002329005626961589, 0.009662417694926262, -0.008118300698697567, -0.0027639782056212425, 0.007815120741724968, 0.024124301970005035, -0.01028093695640564, 0.017039624974131584, 0.022042222321033478, 0.0067556072026491165, -0.004775638692080975, 0.0026946982834488153, 0.0014223671751096845, 0.015793321654200554, -0.0018385965377092361, 0.003369206329807639, 0.008553043007850647, 0.0007582688704133034, 0.03143450617790222, 0.027591228485107422, 0.017955657094717026, -0.0012551327235996723, -0.007151036988943815, 0.052342575043439865, 0.014018675312399864, 0.010412590578198433, -0.0005811755545437336, -0.028277933597564697, -0.009543707594275475, -0.030283067375421524, -0.009833131916821003, -0.009600847028195858, -0.0002491478808224201, 0.0018981188768520951, 0.0015529724769294262, -0.009986153803765774, -0.005406198091804981, -0.01776823401451111, -0.0023402785882353783, -0.00431911600753665, -0.009343322366476059, -0.001815133960917592, 0.003400259418413043, -0.008663741871714592, 0.010498473420739174, 0.0012973410775884986, -0.003705443814396858, -0.004211712628602982, -0.01716594584286213, 0.016745613887906075, -0.006731288507580757, -0.006558835506439209, -0.005324671044945717, 0.01788977161049843, -0.020557530224323273 ]
[ 0.44697508215904236, 0.16117389500141144, -0.08238636702299118, 0.07057715952396393, 0.1747475117444992, 0.2088230699300766, 0.36723124980926514, -0.5952421426773071, -0.07175781577825546, -0.515554666519165, 0.3233373165130615, 0.39186713099479675, -0.35745149850845337, 0.4400164484977722, -0.4262036383152008, 0.859830379486084, 0.14428816735744476, 0.2149469256401062, 0.1201959103345871, -0.6680464148521423, -0.37234222888946533, -0.06587956845760345, 0.29122039675712585, -0.45198163390159607, 0.21489672362804413, -0.05452387034893036, 0.4533211290836334, -0.0010983822867274284, -0.4200397729873657, -0.18824438750743866, -0.1252213418483734, 0.18837833404541016, -0.01977480947971344, -0.17211157083511353, -0.6516364812850952, -0.05759403109550476, -0.23113027215003967, -0.28506579995155334, 0.05135002359747887, -0.2332160472869873, -0.017234666272997856, -0.181350976228714, 0.07226572185754776, 0.5692055821418762, -0.5716373324394226, -0.36382851004600525, -1.7562329769134521, 0.015012944117188454, -0.3914472460746765, 0.06962838023900986, 0.3134775757789612, 0.5730636715888977, 0.03414226323366165, 0.4601632058620453, 0.04051414877176285, 0.22810038924217224, -0.19917544722557068, -0.39244696497917175, 0.013415122404694557, -0.6871281862258911, -0.05401147902011871, 0.10399478673934937, -0.10951202362775803, 0.3903734087944031, 0.2508634328842163, 0.29325658082962036, 0.10613946616649628, -0.22859595715999603, -0.6667079329490662, -0.44173985719680786, -0.09080496430397034, -0.17295002937316895, -0.2147708535194397, 0.22708654403686523, -0.11934048682451248, 0.03202030435204506, 0.06182049959897995, 0.30105462670326233, 0.31146010756492615, -0.15355871617794037, 0.059942133724689484, 0.00822131335735321, -0.07506914436817169, -0.5246342420578003, 0.5073366165161133, -0.05352454632520676, -0.37297651171684265, 0.660051167011261, -0.16546860337257385, -0.14126767218112946, 0.24080075323581696, -0.36951151490211487, 0.1612396091222763, 0.46520140767097473, 0.45336470007896423, -0.09253954142332077, 0.05341717228293419, -0.272554486989975, 0.15709176659584045, 0.4077306091785431, -0.07990468293428421, -0.17414173483848572, 0.1859159916639328, -0.2664968967437744, -0.21644000709056854, -0.6138395071029663, -0.017363155260682106, -0.7890922427177429, -0.7491994500160217, 0.6858425140380859, -0.589773416519165, 0.4494902789592743, 0.2607538104057312, 0.013239321298897266, -0.35602396726608276, 0.354011207818985, -0.00863646250218153, -0.3141121566295624, -0.287747323513031, 0.532900333404541, 0.47133755683898926, 1.3998981714248657, -0.02413264289498329, 0.09789112210273743, 0.5027949810028076, -0.06828577071428299, 0.5402941107749939, 0.5458264350891113, -0.5966756343841553, 0.418825626373291, 0.4167655110359192, 0.8588864207267761, -0.29302480816841125, -0.13659368455410004, -0.33949390053749084, -0.23702770471572876, 0.04500792920589447, -0.03961050510406494, 0.7153157591819763, -0.23290935158729553, -0.5285379886627197, -1.0971341133117676, 0.07403988391160965, -0.46018272638320923, 0.17283880710601807, -0.10879890620708466, 0.024186622351408005, 0.265017569065094, -0.17661431431770325, 0.03175844997167587, 0.161778062582016, -0.1104591116309166, -0.6717877388000488, 0.05243707075715065, -0.04614437371492386, 0.3522106409072876, -0.18403887748718262, -0.39802923798561096, -0.14041148126125336, 0.5218276381492615, 0.26068606972694397, 0.15605033934116364, -0.6520739197731018, -0.12889443337917328, 0.2845236659049988, -0.2748498320579529, 0.349030464887619, 0.5141332745552063, 0.2869890034198761, -0.5858790278434753, -0.4770376980304718, -0.42306047677993774, 0.026493998244404793, -0.7907782196998596, 0.5823217034339905, 0.2072681188583374, 0.2888506352901459, -0.36912617087364197, 0.2762922942638397, 0.2527041733264923, -0.6364924907684326, -0.14570626616477966, -0.4052039682865143, -0.8179828524589539, 0.19971144199371338, -0.08947846293449402, 0.4150647819042206, 0.01232837699353695, 0.07936519384384155, 0.025338636711239815, -0.5179799795150757, -0.15091341733932495, 0.23022842407226562, -0.7394806742668152, 1.753546953201294, -0.4432782530784607, -0.2949499785900116, 1.6516013145446777, -0.1811184585094452, 0.3212537169456482, 0.12121319770812988, 0.4460546672344208, 0.6243201494216919, 0.17048612236976624, -0.6868253946304321, -0.06843583285808563, 0.547328770160675, -0.3733223080635071, -0.6231364607810974, 0.5798786282539368, 0.38334551453590393, -0.12413037568330765, -0.08603601902723312, -0.49711787700653076, 0.13010570406913757, -0.0981784239411354, -0.09392953664064407, 0.20587390661239624, -0.8196016550064087, 0.27387890219688416, 0.6415795087814331, -0.42210710048675537, 0.4507375955581665, 0.823674201965332, -0.31281140446662903, 0.45375722646713257, 0.1013830304145813, 0.09460106492042542, 0.7471815347671509, -0.6424861550331116, -0.15189896523952484, 0.044979196041822433, 0.5301929116249084, -0.6347352862358093, -0.19849467277526855, 0.08520229905843735, -0.11372963339090347, 0.08507049828767776, 0.04004174843430519, 0.33300575613975525, -0.3429768979549408, 0.5297784805297852, -0.8603087067604065, 0.2437400370836258, -0.36874866485595703, -0.4620290994644165, -0.657883882522583, 0.26722806692123413, -0.616666853427887, -0.06748028099536896, 0.08103398978710175, 0.45478421449661255, 0.48780855536460876, -0.47605636715888977, 0.23352357745170593, 0.2503928244113922, -0.31263047456741333, -0.35413220524787903, 0.40408027172088623, -0.21271392703056335, -0.48862895369529724, 0.29292958974838257, -0.0560099259018898, -0.32249265909194946, -0.13357524573802948, 0.17396776378154755, -0.3202536702156067, -0.43052512407302856, 0.6265754103660583, 1.078322172164917, 0.5289982557296753, 0.30733034014701843, -0.7711243629455566, 0.23099413514137268, -0.5454869270324707, -0.2836715281009674, 0.38180819153785706, 0.6230287551879883, -0.623590886592865, -0.5784481167793274, -0.13600334525108337, 0.08380075544118881, 0.5881487131118774, -0.11947574466466904, -0.08968360722064972, 0.014363541267812252, 0.14675204455852509, -0.07108360528945923, -0.5042899250984192, -0.035317469388246536, -0.3867901563644409, 0.36199232935905457, -0.09551357477903366, -0.1733304113149643, 0.674616813659668, 0.05735567584633827, 0.007872626185417175, 0.31959372758865356, 0.4980233311653137, -0.09912904351949692, -0.10186097770929337, 0.3109965920448303, -0.039456889033317566, -0.12579390406608582, 0.25706058740615845, -0.35064050555229187, -0.4084821939468384, 0.5143815279006958, -5.924967288970947, -0.5470965504646301, -0.42277437448501587, 0.19969214498996735, -0.028283588588237762, 0.0658520832657814, 0.8277721405029297, -0.10785976052284241, 0.3897774815559387, -0.03665344789624214, 0.44895046949386597, 0.5413759350776672, 0.3277273178100586, 0.03372732549905777, -0.010408514179289341, 0.33692464232444763, 0.1178983673453331, -0.11008813977241516, 0.4109896719455719, 0.3063270151615143, 0.2408367395401001, 0.18940304219722748, 0.09849243611097336, 0.794441282749176, 0.22128541767597198, 0.22353708744049072, -1.1671876907348633, 0.5631725788116455, -0.06567484140396118, -0.2749361991882324, 0.39185041189193726, -0.1486452966928482, -0.02534708008170128, -0.44575831294059753, 0.5068799257278442, 0.31748005747795105, 0.11668719351291656, -0.18457821011543274, 0.27048271894454956, 0.15274591743946075, 0.4820525348186493, 0.029843635857105255, -0.06055016815662384, 0.029133964329957962, -0.2309381514787674, -0.21179786324501038, -0.0875910148024559, 0.3426155745983124, -0.11163590848445892, 0.9338951110839844, -0.15326954424381256, 0.008470636792480946, 0.7267597913742065, 0.5643194317817688, 0.20720313489437103, -0.11187808960676193, 0.2283415049314499, 0.017149439081549644, -0.6655092239379883, 0.08871186524629593, 0.14071336388587952, -0.7321421504020691, -0.22405222058296204, -0.7382087111473083, -0.3738936483860016, 0.12637987732887268, -0.506895899772644, -0.5519636869430542, 0.40875643491744995, 0.035568878054618835, -0.6685476899147034, 0.40330150723457336, 0.6760741472244263, -0.48350486159324646, 0.4905082583427429, -0.2623104751110077, -0.29145509004592896, 0.1325833797454834, -0.05463699623942375, -0.11304882168769836, -0.3724879324436188, 0.00559186190366745, -0.06216421723365784, 0.19896306097507477, 0.37816405296325684, -0.38007852435112, -0.14894284307956696, -0.297798216342926, -0.37643858790397644, 0.681746244430542, 0.32743415236473083, -0.24741129577159882, 0.31375399231910706, 0.3979411721229553, 0.4097897708415985, 0.7297250628471375, 0.4831959903240204, 0.30414238572120667, 0.6273787021636963, 0.38133808970451355, 1.046586275100708, 0.15094946324825287, -0.048319216817617416, -0.9807534217834473, -0.13435113430023193, -0.33832791447639465, -0.6826240420341492, -0.024151312187314034, 0.27887484431266785, -0.7584385871887207, -0.024211686104536057, -0.168118417263031, -0.5993488430976868, 0.05644100531935692, -0.11022273451089859, 0.23682953417301178, -0.08558541536331177, 0.440175861120224, 0.2290334552526474, -0.0723678469657898, 0.29136669635772705, 0.028760971501469612, -0.42264461517333984, 0.32798463106155396, -0.016757942736148834, -0.524819552898407, -0.019398657605051994, 0.6703258156776428, -0.4734911620616913, 0.2016761600971222, 0.6835194826126099, 0.4731341600418091, -0.5991986393928528, -0.16833963990211487, 0.39198893308639526, -0.34484854340553284, -0.3187040686607361, 0.2578544318675995, -0.04973236471414566, -0.12024205923080444, 0.14348573982715607, -0.5199092626571655, -0.2276986539363861, -0.168201744556427, -0.08657606691122055, -0.09798165410757065, -0.22626158595085144, -0.1466311812400818, 0.13407397270202637, 0.1913013905286789, -0.27888578176498413, -0.32872748374938965, 0.38173800706863403, -0.4178626537322998, -0.04059091955423355, -0.04450041428208351, 0.5725711584091187, 0.03833863139152527, 0.22866107523441315, -0.6791000962257385, -0.1630622148513794, -0.025523696094751358, -0.6298287510871887, -0.2224223017692566, -0.07939187437295914, 0.12347259372472763, -0.18533502519130707, -0.46317562460899353, -0.08810458332300186, 0.3952261507511139, -0.2743716537952423, -0.190166175365448, -0.3083307147026062, -0.17821034789085388, -0.030092304572463036, -0.05609796568751335, 0.20518136024475098, 0.13632410764694214, -0.004900066182017326, -0.0690087303519249, 0.3786192238330841, -0.7960821390151978, 0.039342835545539856, 0.4901444613933563, 0.8389676213264465, -0.22604554891586304, 0.45401400327682495, -0.12923577427864075, -0.3169105350971222, -0.47054755687713623, -0.5847277641296387, -0.0026431975420564413, 0.6052868366241455, -0.25182896852493286, -0.19227442145347595, 0.02689884975552559, 0.22933843731880188, 0.09778260439634323, -0.1636407971382141, -0.08804550766944885, 0.3243153691291809, 0.3507942855358124, -0.2293141484260559, 0.15784123539924622, 0.6101565361022949, -0.08698800951242447, -0.3141525387763977, -0.4379380941390991, -0.23122023046016693, 0.39154455065727234, -0.049237210303545, -0.49712440371513367, 0.10337480157613754, -0.006625663489103317, -0.10447055846452713, -0.216453418135643, 0.10982604324817657, -0.031163914129137993, -0.5693303346633911, 0.4596116840839386, 0.4143960475921631, -0.2740350067615509, -0.14087900519371033, 0.1415424942970276, -0.17134860157966614, -0.476040780544281, 0.7261212468147278, -0.9010136723518372, -0.02712649293243885, 0.1602327823638916, -0.38637420535087585, -0.4071285128593445, 0.30366629362106323, 0.24189364910125732, -0.6679054498672485, -0.5699175000190735, -0.21909146010875702, 0.5413520336151123, -0.030873563140630722, 0.10510684549808502, 0.09030415862798691, 0.36582690477371216, -0.28366443514823914, -0.6128562688827515, -0.12239670753479004, 0.5603702664375305, 0.20370420813560486, -0.5526664853096008, -0.6413129568099976, 0.2721269130706787, 0.19824594259262085, -0.1751835197210312, -0.08355584740638733, 0.015631265938282013, 0.6047855019569397, 0.2921832203865051, -0.12969452142715454, -0.19218969345092773, -0.30383139848709106, 0.5777224898338318, 0.09316915273666382, -0.05135050788521767, -0.2506411075592041, -0.525458812713623, 0.3009912371635437, -0.080849789083004, 0.030275246128439903, -0.5006541013717651, 0.31159308552742004, -0.07178222388029099, 0.005620903801172972, 0.06839965283870697, 0.5649334788322449, 0.7304218411445618, -0.06940702348947525, 0.00007995718624442816, -0.5554145574569702, -0.10659492015838623, 0.31935301423072815, 0.19390258193016052, -0.019688870757818222, -0.5735311508178711, 0.1349368691444397, -0.07099451124668121, 0.676780104637146, -0.46016746759414673, 0.3831530809402466, 0.1765264868736267, 0.36997467279434204, -0.45134037733078003, -0.18171225488185883, 0.03822935372591019, -0.5601513385772705, -0.18780972063541412, -0.09525714814662933, 0.19594347476959229, -0.13834145665168762, -0.0216734129935503, 0.2174302190542221, -0.40064916014671326, -0.3086400032043457, 0.20947611331939697, 0.7688164710998535, -0.6353047490119934, 0.19174133241176605, 0.7250151038169861, 0.016542324796319008, 0.019932348281145096, 0.002203637035563588, -0.07677119225263596, 0.38767653703689575, 0.003695448162034154, 0.3955364525318146, 0.32429006695747375, 0.1077885702252388, 0.1073700487613678, -0.0759553387761116, -0.19219470024108887, 0.2912442088127136, 0.1326548457145691, 0.012515399605035782, 0.4201205372810364, 0.6536877155303955, -0.1578621119260788, -0.3219325542449951, 0.13626068830490112, -0.14303766191005707, 0.30238479375839233, -0.23312479257583618, 0.04570027440786362, 0.46266037225723267, 0.5859867334365845, 0.24195370078086853, 0.4249766767024994, 0.08050734549760818, -0.04745662957429886, 0.19014231860637665, -0.7202715873718262, -0.24360595643520355, 0.08821360021829605, 0.6967894434928894, 0.33103641867637634, -0.12528909742832184, -0.1419675052165985, 0.0898924395442009, 0.6324587464332581, 0.23604731261730194, 0.3454967141151428, -0.29351672530174255, 0.33844414353370667, -0.015266003087162971, 0.10691891610622406, -0.2862672805786133, -0.025461465120315552, -0.36709725856781006, -0.2245464026927948, 0.6548336148262024, -0.2463868409395218, -0.43112248182296753, -0.0241959560662508, 0.1043514758348465, 0.395786851644516, -0.9446057677268982, 0.13224932551383972, -0.24302178621292114, -0.1452319622039795, 0.7519081830978394, 0.4064510464668274, 0.3664739429950714, -0.4917963743209839, -0.04397112876176834, 0.22272108495235443, -0.4002927541732788, -0.0005649373633787036, -0.07267823070287704, -0.5070145726203918, 0.43718111515045166, -0.08829044550657272, -0.35135525465011597, 0.10586466640233994, 0.2643184959888458, -0.05400094389915466, -0.013118710368871689, -0.27622929215431213, -0.1915922462940216, -0.3804597556591034, -0.2255929708480835, -0.16758055984973907, -0.035907916724681854, -0.2887504994869232, -0.1538914442062378, -0.873744785785675, -0.2082946002483368, 0.2534368932247162, -0.1981603503227234, -0.251830518245697, 0.01194772869348526, 0.5349416732788086, 0.08923152834177017, -0.06462626904249191, -0.4057835340499878, -0.1004946306347847, 0.08053135871887207, 0.34439998865127563, -0.4053325951099396, 0.07339997589588165, -0.3006548285484314, -0.216178759932518, -0.8364707231521606, 0.041444648057222366, 0.7085694670677185, 0.20668993890285492, -0.29553255438804626, 0.41309449076652527, 0.24855802953243256, 0.018505390733480453, 0.39000824093818665, -0.3030262887477875, 0.29412710666656494, -0.11199522018432617, 0.023330381140112877, -0.24603323638439178, 0.12670449912548065, 0.2232014536857605, -0.44033026695251465, -0.3703034222126007, 0.05418413132429123, 0.612157940864563, -0.010057530365884304, 0.2272433638572693, -0.23928572237491608, -0.42662426829338074, -0.035928502678871155, 0.37787795066833496, -0.11171416938304901, 0.0975872129201889, 0.10723866522312164, 0.03948630020022392, 0.5210233330726624, -0.4929712414741516, -0.5865589380264282, -0.09392393380403519, 0.14061161875724792, 0.1062750518321991, -0.29163822531700134, 0.5125026702880859, -0.10353309661149979, -0.46927058696746826, -0.19598504900932312, 0.7167459726333618, 0.032404519617557526, -0.19456690549850464, -0.0987032875418663, -0.24398033320903778, -0.14582045376300812, -0.15021272003650665, -0.26867765188217163, -0.3834911584854126, -0.5062188506126404, -0.06744644045829773 ]
BACKGROUND Tanzania has a well-developed network of commercial ITN retailers. In 2004, the government introduced a voucher subsidy for pregnant women and, in mid 2005, helped distribute free nets to under-fives in small number of districts, including Rufiji on the southern coast, during a child health campaign. Contributions of these multiple insecticide-treated net delivery strategies existing at the same time and place to coverage in a poor rural community were assessed. METHODS Cross-sectional household survey in 6,331 members of randomly selected 1,752 households of 31 rural villages of Demographic Surveillance System in Rufiji district, Southern Tanzania was conducted in 2006. A questionnaire was administered to every consenting respondent about net use, treatment status and delivery mechanism. FINDINGS Net use was 62.7% overall, 87.2% amongst infants (0 to 1 year), 81.8% amongst young children (>1 to 5 years), 54.5% amongst older children (6 to 15 years) and 59.6% amongst adults (>15 years). 30.2% of all nets had been treated six months prior to interview. The biggest source of nets used by infants was purchase from the private sector with a voucher subsidy (41.8%). Half of nets used by young children (50.0%) and over a third of those used by older children (37.2%) were obtained free of charge through the vaccination campaign. The largest source of nets amongst the population overall was commercial purchase (45.1% use) and was the primary means for protecting adults (60.2% use). All delivery mechanisms, especially sale of nets at full market price, under-served the poorest but no difference in equity was observed between voucher-subsidized and freely distributed nets. CONCLUSION All three delivery strategies enabled a poor rural community to achieve net coverage high enough to yield both personal and community level protection for the entire population. Each of them reached their relevant target group and free nets only temporarily suppressed the net market, illustrating that in this setting that these are complementary rather than mutually exclusive approaches.
[ -0.0006807401077821851, 0.0020291591063141823, 0.0008618607535026968, 0.01726473867893219, 0.007381575647741556, 0.00822299625724554, 0.007162281312048435, 0.016654720529913902, -0.013350244611501694, -0.02225358970463276, -0.010701892897486687, 0.00673366105183959, -0.016855154186487198, -0.007588727865368128, -0.026238061487674713, 0.0079729575663805, -0.0019275805680081248, 0.021338865160942078, 0.012825297191739082, 0.008372845128178596, -0.01559008751064539, 0.011150732636451721, 0.0085402000695467, 0.023617636412382126, 0.0024324068799614906, 0.0011728594545274973, -0.013807469978928566, -0.027773408219218254, -0.018162190914154053, -0.006021683104336262, 0.009905410930514336, 0.01742464303970337, 0.029662583023309708, 0.005046991165727377, -0.0034778642002493143, 0.006482220254838467, -0.0008379399660043418, 0.015134717337787151, 0.005037090741097927, -0.004157068207859993, 0.01778792031109333, -0.004872300662100315, 0.002644280204549432, 0.013013012707233429, -0.005897894501686096, 0.01045917347073555, -0.007371822372078896, 0.006490752566605806, -0.017637625336647034, 0.007597932126373053, -0.0049808756448328495, -0.010908836498856544, 0.0016211748588830233, 0.022531479597091675, -0.004853393882513046, -0.0004298822022974491, 0.013785140588879585, 0.012784642167389393, 0.003571554785594344, -0.0023704692721366882, -0.002175029134377837, 0.0037341462448239326, -0.003688629250973463, 0.0008421859238296747, 0.002667112508788705, -0.0678756982088089, 0.016326341778039932, -0.004787706770002842, -0.00009619694901630282, 0.00023456302005797625, 0.0185876302421093, 0.009543010964989662, -0.0006704265251755714, -0.010694694705307484, 0.00037830742076039314, -0.0076293861493468285, 0.003570808796212077, 0.009366816841065884, 0.0017793115694075823, 0.008131351321935654, 0.0014397096820175648, -0.013885010965168476, 0.0003415001556277275, 0.012553416192531586, -0.0031677805818617344, -0.0026575177907943726, -0.005567566491663456, -0.007076099514961243, 0.0055531663820147514, 0.007453483063727617, -0.008591191843152046, -0.02391045168042183, 0.0015375595539808273, 0.0056715430691838264, -0.001610342413187027, -0.0009259440703317523, 0.007435946259647608, 0.0019534952007234097, 0.0006430232897400856, 0.005716016516089439, 0.0010603787377476692, -0.008770857937633991, 0.010692535899579525, 0.02424362301826477, 0.01018594205379486, 0.004501970484852791, -0.014686034992337227, 0.002919458784162998, 0.000721239484846592, 0.0023162392899394035, 0.017214369028806686, -0.0027272154111415148, -0.0034124564845114946, 0.008658180944621563, 0.0020226917695254087, -0.004489457234740257, 0.008092396892607212, -0.012124842964112759, 0.005891917273402214, -0.0001876410678960383, 0.009109217673540115, -0.006829067133367062, -0.003527635708451271, -0.0001427407842129469, 0.007053558249026537, -0.008433847688138485, -0.015048021450638771, 0.003903193399310112, -0.0021004495210945606, -0.006317532155662775, -0.00567290373146534, 0.00467288214713335, -0.0014992578653618693, 0.004413268994539976, 0.00774260051548481, 0.0008410518057644367, 0.003687891410663724, 0.0013177139917388558, 0.001959354616701603, -0.014853335916996002, 0.014317920431494713, 0.006811481434851885, -0.0038422662764787674, 0.004570430144667625, 0.002017066814005375, 0.0031517171300947666, -0.00034453324042260647, 0.005291495006531477, 0.02240081876516342, -0.007570873945951462, -0.007112760096788406, -0.002239965135231614, -0.003348201047629118, -0.013665156438946724, 0.0058745453134179115, 0.0027690711431205273, -0.02342156320810318, -0.008070554584264755, -0.003484240500256419, 0.008935757912695408, -0.008987823501229286, 0.010007506236433983, 0.009257028810679913, 0.008013131096959114, 0.016888439655303955, -0.01452645380049944, -0.004340053535997868, 0.0033906723838299513, 0.008180832490324974, 0.003652064362540841, -0.013243598863482475, 0.010989688336849213, -0.001980964560061693, 0.0016645535361021757, -0.0002112160436809063, -0.005036602262407541, -0.014370202086865902, 0.006324409041553736, 0.0009077693684957922, 0.06730366498231888, -0.0028582452796399593, -0.02296452224254608, -0.004194443114101887, -0.025414463132619858, 0.006370380520820618, -0.005361057817935944, 0.01902150548994541, -0.0002362466766498983, 0.0027956394478678703, 0.014177714474499226, -0.00049965875223279, 0.014749184250831604, -0.009870795533061028, 0.014197798445820808, -0.008549289777874947, 0.0018367234151810408, 0.015709811821579933, 0.0000035606790333986282, 0.002266854513436556, 0.007191089913249016, -0.012988567352294922, 0.012167402543127537, 0.012916073203086853, -0.009202786721289158, -0.0076841372065246105, 0.00385467940941453, 0.01848040521144867, -0.01087668351829052, -0.0004998007789254189, -0.011152687482535839, 0.005166834685951471, -0.00031466945074498653, 0.002682441147044301, -0.003937581554055214, 0.005744396708905697, -0.0063554951921105385, 0.005679710768163204, 0.004861847497522831, 0.00948981661349535, -0.01236568484455347, -0.010700777173042297, 0.011215130798518658, 0.014064585790038109, -0.0074382065795362, 0.018597187474370003, 0.01191152073442936, 0.005532965529710054, 0.010224523954093456, -0.0006182780489325523, 0.005107092671096325, -0.0022979748900979757, -0.014936711639165878, -0.006553469691425562, 0.029905080795288086, 0.005563005805015564, -0.010466285049915314, 0.01350472029298544, -0.0025268427561968565, 0.005267289467155933, -0.014878684654831886, 0.008962461724877357, -0.02455449104309082, 0.02111600711941719, 0.0038138527888804674, -0.02116258069872856, -0.01725209876894951, 0.022456839680671692, -0.0004452183493413031, -0.04852849990129471, -0.010662442073225975, 0.003008888103067875, -0.002377016469836235, -0.006715406663715839, -0.00008142704609781504, 0.002596404170617461, 0.010041743516921997, 0.014907632023096085, -0.0055738165974617004, 0.02114994078874588, -0.019735757261514664, 0.01225295476615429, 0.0042353966273367405, -0.010043713264167309, -0.005511383526027203, 0.004322458989918232, -0.00030568335205316544, 0.003276214934885502, 0.005607703700661659, -0.01105133630335331, 0.011212145909667015, 0.003914426080882549, -0.009491084143519402, 0.0030879860278218985, -0.08194632828235626, -0.00969320721924305, 0.018431570380926132, -0.03201703354716301, 0.0037493500858545303, -0.020621752366423607, 0.0011039944365620613, 0.010788653045892715, -0.0029024770483374596, -0.008414153009653091, 0.007175145670771599, 0.02408788539469242, -0.006803479045629501, -0.01120336726307869, 0.013289682567119598, -0.0028469283133745193, 0.004331335891038179, 0.003929321188479662, -0.004849054850637913, 0.006716439966112375, -0.007210706826299429, -0.016488298773765564, 0.00004493631422519684, -0.02065807580947876, -0.011943371966481209, 0.025827445089817047, 0.004510491155087948, -0.011154679581522942, -0.024233084172010422, 0.0029172960203140974, -0.003572427202016115, -0.019880764186382294, 0.011357150971889496, -0.002915736986324191, 0.012706758454442024, 0.012386757880449295, 0.0029415334574878216, -0.0038804386276751757, 0.00970129482448101, 0.0003130864351987839, 0.018128832802176476, 0.002437918446958065, -0.0022971127182245255, -0.0010007678065449, 0.00704190181568265, 0.021656662225723267, -0.006492696702480316, 0.018870986998081207, 0.012397749349474907, 0.00023494637571275234, 0.003641863353550434, 0.0040666828863322735, 0.001862148055806756, 0.010734962299466133, -0.006845822557806969, -0.010621653869748116, 0.003585571888834238, 0.0035241739824414253, -0.00973261147737503, -0.007327020168304443, 0.00022432024707086384, -0.026815447956323624, -0.002986420877277851, -0.0040152836591005325, -0.013566771522164345, -0.0019167710561305285, -0.000835977669339627, 0.002870040014386177, -0.009068840183317661, 0.0017843351233750582, -0.010601735673844814, 0.006434423848986626, -0.0073504941537976265, -0.006285805255174637, -0.009465234354138374, -0.00430673873052001, -0.014168087393045425, -0.0007810111856088042, 0.014918413013219833, 0.0022007240913808346, 0.015996692702174187, 0.016771452501416206, -0.008350883610546589, -0.0018764566630125046, 0.00620664469897747, 0.0047984360717237, 0.015360643155872822, 0.013204541988670826, 0.0026458713691681623, -0.010302321054041386, 0.020625922828912735, -0.020407844334840775, -0.01679263822734356, 0.00354538531973958, -0.0015609071124345064, -0.002486917655915022, -0.01402534544467926, -0.005614507012069225, -0.0026430506259202957, 0.006485543213784695, 0.00015668990090489388, -0.008592926897108555, 0.007439406123012304, -0.011319220066070557, -0.009698443114757538, 0.005318037234246731, 0.011721450835466385, -0.003530042478814721, 0.0029903403483331203, -0.0035470062866806984, 0.01002313382923603, 0.0017652856186032295, -0.005802587140351534, 0.010465562343597412, 0.006744870450347662, -0.005160365253686905, 0.005113514140248299, -0.001895905821584165, 0.07411644607782364, -0.014730571769177914, 0.009432975202798843, -0.008659595623612404, 0.0021684844978153706, -0.0009364588186144829, 0.008071523159742355, -0.0018091441597789526, 0.0011515123769640923, -0.008964356034994125, 0.009096097201108932, -0.020028678700327873, -0.007932836189866066, -0.0030408327002078295, 0.007304445840418339, -0.017344674095511436, 0.0001533105969429016, 0.01138400100171566, 0.013619109988212585, 0.00044869142584502697, 0.0050338264554739, -0.01146618090569973, 0.004786647856235504, 0.0001550847664475441, 0.006781826727092266, -0.0036449595354497433, 0.006924498360604048, -0.00892503373324871, -0.0043218424543738365, 0.0037865014746785164, -0.0131788719445467, -0.016541622579097748, -0.0067879995331168175, -0.017580334097146988, -0.010272412560880184, -0.007901573553681374, -0.004496753215789795, -0.010335274040699005, 0.0031071866396814585, -0.002583735855296254, -0.007893020287156105, -0.010831676423549652, 0.028656531125307083, -0.001062366645783186, 0.005032417830079794, 0.003489045426249504, 0.018106753006577492, -0.005030124913901091, -0.00696419645100832, 0.006736463867127895, 0.007393464911729097, 0.017754575237631798, 0.006587113719433546, 0.002703422214835882, -0.02312503010034561, -0.018090885132551193, -0.006561582908034325, 0.002744220895692706, 0.010843459516763687, -0.013376891613006592, -0.012436875142157078, -0.025459356606006622, 0.022127337753772736, -0.0072920355014503, -0.0012564100325107574, -0.011680248193442822, -0.007092955522239208, -0.004408952314406633, -0.010386638343334198, -0.0022202900145202875, -0.010379417799413204, 0.000696336617693305, -0.0001350254169665277, 0.0064222803339362144, -0.024191277101635933, 0.012317431159317493, -0.014722366817295551, -0.008798026479780674, 0.00979339238256216, -0.018534831702709198, -0.029114557430148125, 0.0019080631900578737, -0.0030913990922272205, -0.013324398547410965, -0.004943822510540485, 0.020466718822717667, 0.011397868394851685, -0.07603834569454193, -0.008076971396803856, -0.00904388539493084, -0.0039020723197609186, -0.00988103449344635, 0.006832398008555174, -0.02066016010940075, 0.03444643318653107, -0.016072232276201248, -0.008582668378949165, 0.014627852477133274, 0.000947734690271318, 0.007992608472704887, -0.009904381819069386, 0.012448208406567574, -0.012776699848473072, -0.026423756033182144, 0.004002307076007128, -0.00846951361745596, -0.015783751383423805, 0.005667779594659805, -0.017056863754987717, -0.021361354738473892, 0.001805138774216175, 0.01686113327741623, -0.08284521847963333, 0.0009555695578455925, 0.010005230084061623, 0.00704060448333621, 0.00491875596344471, -0.003135879058390856, -0.009536856785416603, -0.015904981642961502, 0.025291701778769493, -0.010092384181916714, -0.007499219849705696, -0.0018273270688951015, -0.01079738512635231, -0.020350225269794464, -0.00043658004142344, -0.005868410691618919, 0.005980524234473705, 0.0026613431982696056, 0.018904851749539375, -0.014941927045583725, -0.011458407156169415, -0.012577167712152004, -0.004747905768454075, -0.006557525135576725, 0.001978933112695813, 0.01252227183431387, 0.0027757007628679276, 0.011390525847673416, -0.0132762361317873, -0.0019383779726922512, 0.014859682880342007, -0.0014829481951892376, 0.001401953981257975, -0.01817011833190918, 0.011847060173749924, -0.00256245955824852, 0.023327738046646118, -0.002189617371186614, 0.014375572092831135, 0.002486327663064003, -0.003477315651252866, -0.0004860981716774404, -0.0024586927611380816, 0.02516237273812294, 0.008593184873461723, 0.014044944196939468, 0.007344033569097519, -0.009268681518733501, 0.01409805566072464, -0.010669698938727379, 0.010369086638092995, -0.020964697003364563, -0.009131541475653648, -0.006194882094860077, -0.008190963417291641, -0.004369089845567942, -0.0010328995995223522, 0.012835614383220673, 0.0027185985818505287, 0.010426785796880722, 0.0028786195907741785, 0.014400079846382141, -0.017777815461158752, 0.07277639210224152, 0.002274156082421541, 0.008549540303647518, 0.0011574546806514263, 0.007464253343641758, 0.002428963780403137, -0.001436586957424879, -0.011813430115580559, 0.00826220028102398, -0.008924350142478943, -0.0046876282431185246, -0.005776039324700832, -0.015395794063806534, 0.009150804951786995, 0.014800017699599266, -0.000045993481762707233, -0.012095298618078232, -0.0006478824652731419, -0.018194761127233505, 0.003238471457734704, -0.010917037725448608, -0.005955467000603676, -0.01008124090731144, -0.001377772307023406, 0.010950872674584389, -0.004216190427541733, 0.019337642937898636, 0.0023531648330390453, -0.020810581743717194, 0.0011449971934780478, 0.00370603334158659, 0.010642480105161667, 0.007686476223170757, -0.001630272134207189, 0.012382633984088898, 0.007782092317938805, 0.009355498477816582, 0.0055168988183140755, 0.015166794881224632, 0.00937434658408165, 0.003013771492987871, -0.010824455879628658, 0.008108971640467644, -0.007190394215285778, -0.0031833858229219913, 0.0016716372920200229, -0.006844115909188986, -0.014700425788760185, 0.0042135757394135, -0.011366471648216248, -0.008477477356791496, 0.00017134600784629583, -0.0069144414737820625, 0.01558920368552208, -0.010036991909146309, -0.0052581774070858955, 0.002175498055294156, 0.01662069745361805, 0.016664907336235046, -0.018546435981988907, -0.017697112634778023, 0.002303294138982892, 0.006847001612186432, -0.0043173981830477715, 0.018561219796538353, 0.0003625093959271908, -0.01824078895151615, -0.014756598509848118, -0.004567969590425491, 0.009420722723007202, -0.0055306521244347095, 0.004845248535275459, 0.0031928070820868015, -0.001324149314314127, 0.0160469152033329, 0.0052231838926672935, 0.016602035611867905, -0.006792622618377209, -0.0018227413529530168, 0.0023842663504183292, -0.010184732265770435, -0.00455827359110117, 0.006118112709373236, -0.019512739032506943, -0.011678970418870449, -0.018130291253328323, 0.018872302025556564, 0.007214426528662443, -0.00047442561481148005, 0.011516236700117588, -0.015950489789247513, 0.0012496192939579487, 0.004138884134590626, -0.003989287652075291, 0.004240371286869049, 0.03228602185845375, -0.008251906372606754, 0.003997537773102522, 0.011977375485002995, 0.007093070540577173, -0.0064623658545315266, -0.0023099039681255817, -0.00481437286362052, 0.00253419391810894, -0.021729975938796997, 0.005145343020558357, -0.0015176169108599424, 0.018144844099879265, -0.008482147008180618, -0.0019718336407095194, 0.009850459173321724, -0.002389571163803339, 0.00338569818995893, 0.0008363992092199624, -0.007358929608017206, -0.005274125374853611, -0.002968735760077834, -0.011968331411480904, -0.0018504601903259754, -0.010430490598082542, 0.003214373718947172, -0.0027903993614017963, -0.0023156101815402508, 0.027799712494015694, -0.024165138602256775, 0.00926932692527771, -0.006358399987220764, 0.022481529042124748, 0.03177367150783539, 0.002553015947341919, 0.010744364932179451, -0.001307011814787984, 0.005152208264917135, -0.0021189101971685886, -0.00395994633436203, 0.01714041270315647, 0.008385521359741688, -0.009966391138732433, 0.0012517657596617937, 0.013296634890139103, 0.00781912449747324, 0.003210980910807848, 0.0037524905055761337, -0.014207148924469948, 0.007948357611894608, 0.006178856827318668, 0.0230662003159523, 0.016516633331775665, 0.01724047213792801, -0.005462575703859329, -0.007387164048850536, 0.0010013802675530314, -0.0009144237847067416, -0.0032276930287480354, -0.0043677338398993015, 0.004213464446365833, 0.018473252654075623, -0.00609596585854888, -0.009446095675230026, -0.0034264065325260162, -0.014489607885479927, -0.001869049621745944, 0.003321683267131448, -0.010244082659482956, -0.006687667220830917, -0.00353272445499897, 0.00547571387141943, 0.0038447389379143715, 0.001433204161003232, 0.0039000152610242367, -0.0008411823073402047, -0.030624888837337494, -0.011724868789315224, 0.00027670536655932665, -0.005224121734499931, 0.003450519172474742, 0.0006314916536211967, 0.013581156730651855, -0.021496865898370743, 0.019984450191259384, -0.011047418229281902, 0.01649772748351097, 0.0003893596585839987, -0.011018266901373863, -0.0028365645557641983, -0.01559356041252613, 0.004484950564801693, 0.005648365709930658, 0.006447305902838707, 0.014333243481814861, -0.0075488220900297165, -0.016551675274968147, -0.017299380153417587, 0.005351961124688387, 0.0186928641051054, -0.015491390600800514, -0.00997985154390335, -0.007794104050844908, 0.006905941292643547, 0.005074139218777418, -0.0026549960020929575, 0.007083142176270485 ]
[ 0.4945317506790161, -0.5347662568092346, -0.00876784697175026, -0.17754952609539032, -0.1262742131948471, 0.8086056709289551, 0.14327462017536163, 0.1755942553281784, -0.6185945868492126, -0.45682111382484436, 0.09561793506145477, 0.061728768050670624, 0.11986494809389114, 0.040752142667770386, -0.4423227608203888, 0.6431661248207092, 0.5265867114067078, 0.527951717376709, -0.19178076088428497, -0.021953145042061806, -0.5137866139411926, -0.2324681580066681, -0.12422064691781998, 0.3197149932384491, 0.15714621543884277, 0.18955887854099274, 0.9437929391860962, 0.04218103736639023, 0.13292324542999268, -0.1350652426481247, 0.28954198956489563, 0.6230942606925964, 0.49632012844085693, 0.22487181425094604, 0.36581140756607056, -0.5904056429862976, 0.1985989212989807, 0.10580969601869583, -0.04228917509317398, -0.40529876947402954, -0.34941038489341736, -0.25460487604141235, 0.24807970225811005, 0.4587459862232208, -0.011336342431604862, -0.7212249636650085, -0.9079774618148804, 0.6842427849769592, -0.10194402188062668, 0.2755131125450134, -0.31255000829696655, 0.2485561966896057, 0.5012241005897522, 0.07293183356523514, 0.340617835521698, 0.04081784561276436, -0.2909235656261444, 0.20716966688632965, 0.5008311867713928, -0.44283851981163025, 0.09951156377792358, -0.08231852203607559, 0.407372385263443, -0.1021217331290245, -0.4263637065887451, 0.3750408887863159, 0.18269792199134827, 0.26697075366973877, 0.2250448316335678, -0.669760525226593, 0.10849525779485703, -0.49298733472824097, -0.528913140296936, -0.04780898988246918, -0.22099465131759644, 0.20025862753391266, 0.14017581939697266, -0.15372620522975922, 0.479710191488266, -0.06184777617454529, -0.06581518054008484, -0.24222201108932495, 0.27921897172927856, -0.12980112433433533, 0.6489064693450928, 0.30131104588508606, 0.21346694231033325, 0.3908441960811615, 0.17852433025836945, 0.021527182310819626, -0.2879093885421753, -0.29714035987854004, 0.42307788133621216, 0.49974316358566284, -0.4301443099975586, 0.371269166469574, 0.15594817698001862, -0.17201897501945496, 0.6607261300086975, -0.10753784328699112, -0.17249320447444916, 0.05600143224000931, -0.2036101222038269, 0.2808195948600769, -0.9774824380874634, 0.03386979177594185, -0.06850741803646088, -0.08335529267787933, -0.6440272927284241, -0.14106881618499756, -0.3314448595046997, 0.012134682387113571, -0.4323236644268036, -0.15547576546669006, -0.2599160075187683, 0.2689649164676666, 0.17483913898468018, -0.3827453553676605, -0.540087103843689, 0.10587968677282333, -0.39386245608329773, 0.6547510623931885, 0.021705390885472298, 0.9967060685157776, 0.1840263456106186, 0.3631455600261688, 0.6724960803985596, 0.4970453679561615, -0.3396223485469818, 0.6926085352897644, 0.6303426027297974, 0.3005774915218353, -0.33179473876953125, 0.13584460318088531, -0.09414541721343994, -0.5183368921279907, 0.4804372787475586, 0.1691061407327652, 0.48320046067237854, -0.1497064083814621, -0.3960150480270386, 0.08284185081720352, -0.3578278124332428, 0.00139949272852391, 0.04363125190138817, -0.7375900745391846, 0.07913351058959961, -0.10072252154350281, -0.08509300649166107, -0.5182856321334839, 0.2630176544189453, -0.3867143392562866, 0.22108110785484314, -0.6291188597679138, -0.05959351733326912, 0.3197539746761322, -0.09521009027957916, -0.2736598253250122, -0.09150069206953049, 0.21118487417697906, 0.4965600371360779, 0.5820484757423401, -0.3753373622894287, -0.10233134031295776, 0.2170475423336029, -0.008751352317631245, -0.5908476710319519, -0.0295547042042017, 0.21800018846988678, 0.6053836941719055, -0.25420111417770386, 0.2872655391693115, -0.44897177815437317, -0.49441349506378174, -0.44872045516967773, 0.38053998351097107, -0.09502223134040833, 0.018737727776169777, 0.01086183451116085, -0.12130922824144363, -0.6913800835609436, 0.21646732091903687, 0.595331609249115, -0.23944661021232605, -0.29203641414642334, 0.3227091431617737, -0.1920638382434845, 0.05477328225970268, -0.02049197070300579, -0.10991322994232178, -0.575256884098053, -0.4706385135650635, 0.5601665377616882, -0.5930603742599487, 1.0837000608444214, 0.20441067218780518, -0.1356300562620163, 1.2286748886108398, 0.2979983687400818, 0.055758483707904816, 0.02654494345188141, 0.14224939048290253, 0.6018857955932617, -0.04285744950175285, -1.1846309900283813, -0.0032667398918420076, -0.348758339881897, 0.04611869156360626, -0.10806145519018173, -0.29401570558547974, 0.2256067991256714, -0.0600336417555809, -0.615563690662384, 0.03243767470121384, 0.031215552240610123, 0.6668369174003601, -0.29981306195259094, 0.20424368977546692, 0.4254527688026428, -0.3069559931755066, -0.2211500108242035, -0.662571132183075, 0.059947069734334946, 0.3052959740161896, 0.32240551710128784, 0.3654754161834717, 0.6315348148345947, -0.149314746260643, 0.5665379762649536, -0.3236196041107178, -0.13602395355701447, -0.07686855643987656, 0.054299745708703995, -0.7424382567405701, -0.36595189571380615, 0.03408332169055939, -0.09705265611410141, -0.13693681359291077, 0.18586842715740204, 0.107272207736969, 0.11539326608181, 0.16489750146865845, -0.5179359316825867, -0.29766473174095154, 0.0036426919978111982, -0.0077786217443645, -0.5787017941474915, -0.22393698990345, -0.3132266104221344, 0.22381456196308136, 0.04599335044622421, 0.21272584795951843, 0.04412388429045677, -0.18172059953212738, 0.009722335264086723, 0.24252288043498993, 0.24502648413181305, -0.7020308971405029, 0.4744012951850891, -0.40944740176200867, 0.22118288278579712, 0.35646647214889526, 0.052146099507808685, 0.7248989939689636, 0.307849258184433, -0.7204442620277405, -0.04699951782822609, -0.3506220579147339, 0.5889731645584106, 0.41707533597946167, 0.4160385727882385, 0.13045275211334229, -0.36928170919418335, -0.06724231690168381, -0.13031072914600372, -0.9393972754478455, 0.34865251183509827, 0.8744199872016907, -0.7077766060829163, -1.0132884979248047, -0.25314202904701233, 0.0964791476726532, 0.42617934942245483, -0.505152702331543, 0.23073340952396393, -0.18703849613666534, -0.03058152087032795, 0.09629930555820465, -0.594514012336731, 0.23821136355400085, 0.14715933799743652, 0.3725884258747101, -0.09705221652984619, -0.2359069138765335, 0.19121582806110382, 0.6144207715988159, -0.33133402466773987, 0.42118945717811584, 0.647338330745697, -0.3782953917980194, 0.30950605869293213, 0.28159892559051514, -0.1813690960407257, 0.027138197794556618, -0.311436265707016, -0.0910034030675888, -0.25759848952293396, -0.5835325717926025, -5.824954032897949, 0.7778012156486511, -0.07879780232906342, -0.2461720108985901, -0.4271792769432068, 0.11693011969327927, 1.008190631866455, -0.12047044932842255, 0.34957411885261536, -0.24759475886821747, -0.03368634730577469, 0.444473534822464, 0.05284300073981285, 0.14660002291202545, -0.05266957730054855, 0.5387058854103088, 0.5767807960510254, -0.024316364899277687, 0.6624487638473511, 0.4770674407482147, -0.14623913168907166, -0.29969972372055054, -0.113910011947155, 0.35396742820739746, 0.4377961754798889, 0.2603960633277893, -1.0474568605422974, -0.26208174228668213, -0.38603243231773376, -0.44115468859672546, 0.04374063387513161, -0.5537562370300293, 0.3795163333415985, 0.24456530809402466, -0.17733825743198395, -0.054155584424734116, 0.3722548484802246, 0.16271387040615082, -0.15704882144927979, -0.6170687079429626, 0.14402559399604797, 0.6250905990600586, 0.07155770808458328, -0.2591913342475891, 0.4223799705505371, 0.09287141263484955, -0.061869457364082336, -0.384859174489975, -0.13508817553520203, 0.7929387092590332, 0.05558819696307182, -0.39116623997688293, -0.3164709210395813, 0.5805835127830505, -0.2057117521762848, 0.01600249856710434, -0.1182994470000267, 0.22730161249637604, -0.3326053023338318, 0.3379492163658142, 0.1346665471792221, -0.04197896644473076, 0.28832411766052246, -0.6489735841751099, -0.22835390269756317, 0.30668187141418457, -1.011646032333374, -0.4862586557865143, -0.14328902959823608, -0.06132170557975769, -0.21129828691482544, -0.11643146723508835, 0.2169111669063568, -0.612992525100708, -0.1108219176530838, -0.8629316687583923, -0.33688706159591675, -0.19799110293388367, 0.11477545648813248, -0.07849785685539246, 0.200050950050354, -0.3036152422428131, 0.44086727499961853, -0.10572117567062378, -0.4190747141838074, -0.04612983390688896, 0.0765458196401596, -0.30635786056518555, 0.23420299589633942, -0.09874305129051208, 0.7971815466880798, -0.2638849914073944, -0.07585932314395905, 0.1640663743019104, 0.7375348806381226, 0.6310425996780396, 0.41788986325263977, -0.05562007799744606, 0.011855077929794788, -0.5731308460235596, 0.5484440922737122, -0.17541581392288208, -0.5009115934371948, -0.7076441645622253, 0.2866126000881195, 0.17406615614891052, -0.6709703207015991, -0.17596125602722168, 0.8835538625717163, -0.7049762606620789, 0.1863352507352829, -0.4129185080528259, -0.8326613903045654, 0.22013503313064575, 0.2876608371734619, -0.3978368639945984, 0.18805204331874847, -0.32093602418899536, 0.6009740233421326, -0.17221584916114807, 0.5243642330169678, 0.0073180911131203175, -0.17244471609592438, 0.36936306953430176, 0.41335469484329224, -0.5298551321029663, 0.3109227418899536, 0.09038540720939636, -0.6626323461532593, 0.10719803720712662, 0.35812148451805115, 0.20208153128623962, -0.062236249446868896, -0.17010590434074402, 0.12845389544963837, -0.17901891469955444, -0.4571399986743927, -0.4680967330932617, 0.3607209622859955, 0.3356754183769226, -0.36802932620048523, 0.06885824352502823, 0.027523616328835487, 0.4788258671760559, 0.9165888428688049, 0.14706575870513916, -0.030361197888851166, -0.15537726879119873, -0.611811101436615, 0.190641388297081, 0.2643490135669708, 0.01179263275116682, 0.7086931467056274, -0.15002521872520447, -0.29881274700164795, -0.13916514813899994, 0.5344607830047607, 0.1112806648015976, -0.31411653757095337, -0.5182150602340698, 0.7039818167686462, 0.022798093035817146, -1.1979998350143433, 0.5228338241577148, 0.11074863374233246, -0.6744552254676819, -0.19045881927013397, -0.5649704933166504, 0.2694380581378937, 0.1434587985277176, 0.29345011711120605, -0.3344744145870209, 0.21969722211360931, 0.14847396314144135, 0.03269645571708679, -0.16329321265220642, -0.48328688740730286, 0.6485490798950195, -0.4774182438850403, 0.20970818400382996, 0.0075567057356238365, 0.0024103960022330284, -0.3894251883029938, 0.039442818611860275, 0.8565914034843445, 0.37731030583381653, -0.035624220967292786, -0.19634763896465302, -0.15701942145824432, -0.17620423436164856, 0.5811351537704468, -0.018338099122047424, 0.4271412193775177, 0.1520577073097229, -0.29911282658576965, -0.5822508931159973, -0.10883236676454544, 0.6826208233833313, -0.5229642391204834, 0.06405186653137207, -0.5296076536178589, 0.6196364760398865, -0.4826827943325043, 0.43168240785598755, 0.15826179087162018, 0.008723168633878231, 0.23951168358325958, -0.1831287443637848, -0.22055953741073608, -0.4060490131378174, -0.5063510537147522, -0.22681716084480286, -0.14128409326076508, 0.44805848598480225, -0.48913440108299255, 0.37486645579338074, -0.5552880764007568, -0.3889864981174469, 0.028210200369358063, 0.1745666116476059, -0.09098055958747864, -0.2821202278137207, -0.5386385917663574, 0.12399426102638245, -0.2460576742887497, 0.3363310694694519, 0.9366390109062195, -0.890511691570282, -0.5335068702697754, 0.17747491598129272, -0.47401943802833557, -0.11688742786645889, 0.5985011458396912, 0.3302463889122009, -0.9010033011436462, 0.28785544633865356, 0.07686223089694977, -0.19103766977787018, 0.7267707586288452, 0.6968777775764465, 0.07002290338277817, 0.6591905951499939, -0.35451769828796387, -0.8964821696281433, 0.165186807513237, 0.22547689080238342, 0.051097214221954346, -0.22484023869037628, -0.42537280917167664, 0.7107622027397156, -0.08937706053256989, -0.24391651153564453, 0.1778818666934967, -0.4740035831928253, 0.29401659965515137, -0.20632797479629517, -0.45927026867866516, 0.11758348345756531, 0.21975453197956085, 0.0364641398191452, -0.12008220702409744, -0.2872738242149353, -0.14757075905799866, -0.19344912469387054, 0.20438814163208008, -0.21158459782600403, -0.19589360058307648, -0.29992738366127014, -0.10985641926527023, -0.5078321695327759, -0.2520657777786255, -0.20450501143932343, 0.5668866038322449, 0.1999301016330719, 0.33772915601730347, -0.1877594292163849, -0.5656936168670654, 0.12357483059167862, -0.18377594649791718, -0.17898018658161163, -0.684394896030426, -0.41684186458587646, 0.1629801243543625, -0.05403013154864311, 0.054385583847761154, -0.5521971583366394, 0.2509651482105255, 0.054889801889657974, -0.45611265301704407, -0.6470997929573059, 0.017607854679226875, 0.07847416400909424, -0.18656031787395477, -0.09935656189918518, -0.016516121104359627, -0.18019598722457886, 0.3255758583545685, 0.1750672310590744, -0.21930041909217834, -0.33559519052505493, -0.044307395815849304, 0.669083297252655, 0.0326417051255703, -0.37199148535728455, 0.45919403433799744, -0.09443295001983643, 0.32732853293418884, -0.03774816915392876, 0.18797282874584198, 0.2273263782262802, 0.13316252827644348, -0.17684927582740784, 0.5116969347000122, 0.0321810245513916, -0.5417889356613159, 0.014616783708333969, -0.14692381024360657, -0.5659806728363037, 0.8179065585136414, -0.1342286616563797, 0.37993738055229187, 0.8544214367866516, 0.5082714557647705, 0.6639312505722046, 0.011474882252514362, 0.6203340888023376, -0.17228752374649048, 0.41901516914367676, 0.42778223752975464, -0.03193700313568115, -0.23770593106746674, 0.6317871809005737, -0.4804813861846924, -0.12029099464416504, 0.19334664940834045, 0.41603562235832214, 0.2551546096801758, -0.1146058514714241, -0.005939855240285397, 0.44527557492256165, 0.8342512845993042, 0.21080631017684937, 0.3738609850406647, -0.19849079847335815, -0.08070578426122665, 0.16859279572963715, 0.24873614311218262, 0.16507159173488617, 0.5887919068336487, 0.1370764523744583, 0.10762649774551392, -0.3508909046649933, -0.3230207562446594, 0.2674267292022705, -0.031171102076768875, 0.2687283158302307, -0.06666012108325958, -0.29065990447998047, -0.7735109925270081, 0.07935923337936401, 0.1772943139076233, 0.02574196271598339, -0.24180267751216888, 0.1657312661409378, -0.1362517774105072, 0.021729644387960434, 0.5460279583930969, 0.058773089200258255, -0.09242047369480133, -0.09919413179159164, 0.308619886636734, -0.33657851815223694, -0.21117570996284485, 0.21159295737743378, -0.09339601546525955, -0.3255600035190582, -0.27779340744018555, 0.11503524333238602, 0.17416097223758698, 0.45937296748161316, -0.04028870165348053, -0.1020730584859848, 0.24486075341701508, -0.18764309585094452, 0.4367614984512329, -0.2866000533103943, -0.4279571771621704, 0.2060706913471222, -0.38812264800071716, 0.11647234857082367, -0.19202984869480133, -0.5859585404396057, -0.08688024431467056, 0.5743817687034607, -0.5738646984100342, 0.42759227752685547, 0.0016090348362922668, 0.9170873165130615, 0.4601541757583618, 0.06106354668736458, -0.502173900604248, -0.05611305683851242, -0.06539230048656464, 0.44985270500183105, -0.0025789777282625437, 0.31227707862854004, -0.8542383313179016, -0.5504093766212463, -0.786768913269043, 0.4208226799964905, 0.6506291031837463, 0.5145749449729919, -0.13382084667682648, -0.11233147978782654, 0.049375712871551514, 0.5333345532417297, 0.48055416345596313, -0.16205134987831116, -0.5977509617805481, -0.33347979187965393, -0.21249496936798096, -0.780165433883667, 0.2765595018863678, -0.03536679595708847, 0.013975376263260841, -0.07747410982847214, 0.2949310839176178, 0.7509698271751404, -0.39949747920036316, 0.7117071747779846, -0.4500976800918579, -0.154704749584198, -0.582791268825531, 0.43720975518226624, -0.4532371461391449, 0.4366385042667389, 0.36818668246269226, 0.35037505626678467, 0.3961968421936035, -0.3113122880458832, 0.12203847616910934, -0.6331324577331543, 0.3277837932109833, -0.2815260589122772, 0.014206633903086185, 0.4055368900299072, 0.15299485623836517, 0.17360706627368927, -1.1317256689071655, 0.03167504444718361, -0.4781864881515503, -1.030263900756836, 0.06365524232387543, -0.06919699907302856, -0.23209376633167267, -0.2589668035507202, -0.12490583956241608, -0.2428164929151535, -0.5545644164085388, -0.5281971096992493 ]
A total of 527 blood samples was obtained from an unselected population of women between 36 and 40 weeks gestation. Serum human chorionic gonadotropin (hCG) levels were measured using a specific radioimmunoassay for the beta 1-subunit of hCG. Serum hCG levels were higher in primigravidae and in women carrying female fetuses. They were also related to the birthweight of the child and to the occurrence of fetal distress.
[ -0.008786879479885101, -0.0016886761877685785, -0.011796592734754086, 0.02680950239300728, 0.04201662912964821, 0.0095155518501997, 0.012058412656188011, -0.022616438567638397, -0.014985834248363972, -0.036567892879247665, 0.00649286899715662, 0.005745357368141413, -0.007378803100436926, -0.0039342246018350124, -0.036325905472040176, -0.027114495635032654, -0.023936863988637924, 0.01207166351377964, 0.0023636547848582268, 0.0177705530077219, 0.03228800743818283, -0.029371479526162148, 0.010738895274698734, 0.007476408034563065, 0.029751423746347427, 0.0096804304048419, -0.008271236903965473, -0.022242549806833267, 0.005053303670138121, -0.003443510038778186, -0.019750205799937248, 0.021647123619914055, -0.012928485870361328, -0.01821325346827507, 0.016899432986974716, -0.005455546081066132, -0.004808369558304548, 0.017643865197896957, -0.012480385601520538, -0.0036597298458218575, 0.004249861463904381, -0.02181215211749077, 0.004702271427959204, 0.02567390538752079, -0.008892408572137356, -0.02254808321595192, -0.011605361476540565, -0.013227337040007114, 0.014294927939772606, 0.008410903625190258, -0.0069586774334311485, -0.005338984541594982, -0.012610523961484432, 0.0066603138111531734, -0.007193113677203655, -0.00770217040553689, 0.01884380169212818, 0.03061656281352043, -0.04552169516682625, -0.00219179829582572, -0.0025714379735291004, 0.007717657368630171, 0.0036703390069305897, -0.026829689741134644, -0.010258342139422894, -0.06663921475410461, 0.004075356759130955, -0.033932898193597794, -0.004742038436233997, 0.01621432416141033, -0.01141023263335228, 0.011767088435590267, 0.024813739582896233, -0.019985320046544075, -0.031837787479162216, 0.0008139843121170998, -0.0054587810300290585, -0.022018402814865112, -0.028366558253765106, 0.0032612490467727184, 0.023351019248366356, -0.011894740164279938, 0.02062053792178631, 0.009369544684886932, 0.02174077369272709, 0.0021954523399472237, -0.016472917050123215, 0.00443390803411603, 0.006734742317348719, -0.009790236130356789, 0.009421804919838905, 0.022245662286877632, 0.006392580922693014, -0.008191252127289772, 0.0033683031797409058, 0.024732178077101707, 0.005945276934653521, -0.021312791854143143, 0.013718872331082821, 0.008193944580852985, -0.012164413928985596, 0.02272878959774971, 0.013713119551539421, -0.03510928526520729, -0.028551185503602028, 0.006911499425768852, 0.02945609763264656, 0.017765743657946587, -0.03031829372048378, 0.0027206053491681814, -0.027585724368691444, 0.024835368618369102, 0.019236989319324493, -0.006283769384026527, 0.030268942937254906, 0.0050440640188753605, 0.00710779894143343, 0.024027928709983826, 0.0063206846825778484, 0.03158731758594513, 0.009460748173296452, -0.0015513156540691853, 0.004824562929570675, -0.01508278213441372, -0.0013265376910567284, 0.0057181003503501415, 0.01896638236939907, -0.007505437824875116, -0.02158403769135475, -0.004101848695427179, -0.005040742922574282, 0.003293654415756464, 0.004066558089107275, -0.026744438335299492, -0.012999771162867546, 0.004082235973328352, 0.005362930707633495, 0.005441324785351753, 0.004877251572906971, -0.010390411131083965, -0.002572855446487665, 0.010509160347282887, -0.004860034212470055, 0.010552385821938515, -0.003023310797289014, -0.004388822242617607, -0.0043450575321912766, -0.005564388819038868, 0.0035344441421329975, -0.042771998792886734, 0.018846938386559486, -0.03800663352012634, -0.02976171113550663, -0.01316948514431715, -0.01317217480391264, -0.010242330841720104, -0.0283316932618618, 0.008262509480118752, 0.021989606320858, 0.0010213862406089902, -0.005496562458574772, -0.012628552503883839, -0.0012037382693961263, 0.010509354062378407, -0.015320601873099804, 0.007069253828376532, -0.031922295689582825, 0.007216436322778463, -0.004231024067848921, 0.003733446355909109, -0.004660275764763355, 0.0021104468032717705, 0.04434473067522049, 0.016086896881461143, -0.013399036601185799, -0.004111001268029213, 0.010086373426020145, 0.005623908247798681, -0.010766462422907352, 0.06609240174293518, -0.001255993265658617, -0.0004099440120626241, -0.03866640850901604, 0.00658379215747118, 0.02258874662220478, -0.002302673878148198, 0.0024749364238232374, -0.0035828843247145414, -0.0052949776872992516, 0.032381754368543625, 0.014990810304880142, -0.018708383664488792, 0.024591416120529175, 0.0076921246945858, 0.01845434308052063, 0.004706669133156538, 0.02520900033414364, 0.012730966322124004, -0.013972125947475433, -0.031692273914813995, 0.01865771785378456, 0.00020846071129199117, -0.004613360855728388, 0.03876801207661629, -0.008913817815482616, 0.014086045324802399, 0.01444526482373476, -0.030890800058841705, 0.004981229081749916, 0.021382657811045647, 0.010587196797132492, 0.007977309636771679, 0.0078556127846241, 0.004178429022431374, 0.00001680667992332019, 0.0034470639657229185, -0.008023238740861416, 0.02229754626750946, -0.0386565625667572, -0.01714180037379265, 0.012674529105424881, -0.004728109110146761, 0.035774197429418564, -0.009371251799166203, -0.002567739924415946, -0.045031022280454636, 0.012195388786494732, 0.006882994901388884, -0.015169798396527767, 0.018463769927620888, -0.011627106927335262, -0.018239473924040794, -0.01394793950021267, 0.051602236926555634, -0.015202333219349384, 0.008695477619767189, 0.015306472778320312, -0.007658558897674084, 0.012103925459086895, -0.013140559196472168, -0.023707453161478043, -0.0019007646478712559, 0.030950311571359634, -0.035010240972042084, -0.011974779888987541, 0.010215767659246922, 0.001095317187719047, 0.021089497953653336, -0.016907289624214172, 0.006933217402547598, 0.010842014104127884, -0.011067694053053856, -0.014476225711405277, -0.0043775602243840694, -0.0013951564906165004, -0.012437519617378712, -0.012341279536485672, 0.03179965913295746, 0.027627455070614815, -0.009343937039375305, 0.020300569012761116, 0.003931593149900436, 0.01585773192346096, 0.010402792133390903, -0.004589088261127472, -0.0018535386770963669, 0.0016438793390989304, -0.006564191542565823, 0.02122470922768116, 0.012757369317114353, 0.004375549964606762, -0.013738326728343964, -0.006118654273450375, -0.08145732432603836, -0.018573103472590446, 0.010304415598511696, -0.012501378543674946, 0.005406755954027176, 0.052387647330760956, 0.015497676096856594, 0.0034842262975871563, 0.012061056680977345, -0.018132591620087624, 0.010057284496724606, 0.02308124490082264, -0.00726429745554924, 0.0030466746538877487, -0.019501810893416405, 0.0023690215311944485, 0.002823431510478258, -0.026820674538612366, -0.030639301985502243, 0.02814580500125885, -0.0004520259390119463, 0.000520693080034107, 0.015571831725537777, 0.0037062529008835554, 0.024899959564208984, 0.02363711968064308, 0.007207849062979221, -0.02750607766211033, -0.02225624956190586, -0.002004696521908045, 0.0013815122656524181, -0.00017841708904597908, 0.030638137832283974, 0.02225496806204319, 0.024321606382727623, -0.02321964129805565, -0.0132424496114254, 0.017246315255761147, -0.011194715276360512, -0.019386637955904007, -0.028403669595718384, 0.00020632213272619992, 0.024701181799173355, -0.007504833396524191, -0.008690196089446545, -0.00026061711832880974, 0.01701141893863678, 0.03754299879074097, 0.019986102357506752, 0.012661660090088844, -0.018773501738905907, 0.011144154705107212, 0.02916531451046467, 0.011108634993433952, -0.026484858244657516, 0.009738821536302567, -0.013021040707826614, -0.0016109085408970714, -0.00812476221472025, -0.0075579057447612286, 0.023613685742020607, 0.01289786584675312, -0.0392901748418808, 0.010983153246343136, 0.013614298775792122, 0.012431398034095764, 0.0006243152311071754, -0.01561915222555399, -0.00932651199400425, 0.010988408699631691, 0.02652943693101406, -0.010612860321998596, -0.019438229501247406, -0.012133244425058365, 0.008460675366222858, -0.0022786520421504974, -0.015132000669836998, -0.014906364493072033, 0.014210469089448452, -0.005024761892855167, -0.03313111513853073, -0.007631492801010609, 0.002500084461644292, -0.009944388642907143, -0.013491952791810036, 0.03073176182806492, 0.015099801123142242, 0.00759428646415472, 0.018033890053629875, -0.019149519503116608, 0.033609189093112946, 0.028352288529276848, 0.02978786639869213, 0.015620430000126362, 0.006807668134570122, -0.0042554535903036594, -0.0015514492988586426, 0.0028145520482212305, 0.021566243842244148, 0.008981924504041672, -0.018115157261490822, -0.01108063105493784, 0.01866787299513817, -0.009577037766575813, 0.015716485679149628, 0.011449512094259262, 0.00384004064835608, 0.022129427641630173, 0.011055003851652145, -0.0036498408298939466, 0.006584161426872015, -0.011911526322364807, -0.010211179032921791, 0.0043508317321538925, 0.004410834051668644, 0.010550053790211678, 0.010790852829813957, 0.038871880620718, 0.0713421031832695, -0.00023413958842866123, 0.00569238280877471, -0.019624575972557068, 0.004896111786365509, -0.019140221178531647, 0.003527440596371889, 0.01695822738111019, -0.022386906668543816, -0.0009310951572842896, 0.015615316107869148, 0.0005814203177578747, 0.025509990751743317, 0.015154561027884483, -0.012947090901434422, 0.008359111845493317, -0.009860514663159847, -0.017396220937371254, 0.021070562303066254, -0.007918216288089752, -0.02383616752922535, 0.01584087684750557, -0.006314229220151901, -0.002640336286276579, 0.004166103899478912, 0.0015362710691988468, -0.009435965679585934, -0.016564099118113518, -0.040692806243896484, 0.008438359946012497, 0.0032918478827923536, 0.009966203942894936, -0.007235472556203604, -0.004024127032607794, 0.007663823198527098, 0.0007813259144313633, 0.028453096747398376, 0.012288681231439114, -0.002918775426223874, 0.0031878482550382614, 0.016408992931246758, -0.011741222813725471, 0.008912064135074615, 0.007979849353432655, 0.019627708941698074, 0.0043478249572217464, 0.0009824110893532634, -0.011935464106500149, 0.0013234646758064628, -0.0039988975040614605, -0.005192959681153297, -0.010736910626292229, 0.015660615637898445, -0.0061205788515508175, -0.007696138229221106, 0.003983509261161089, -0.017776096239686012, 0.008330467157065868, 0.005312198307365179, -0.020193492993712425, 0.006228415761142969, -0.0103684663772583, -0.0061045363545417786, -0.02110036462545395, 0.0007612046902067959, 0.005281463731080294, 0.011380252428352833, -0.0028650660533457994, -0.0032151059713214636, -0.0014826023252680898, -0.005037324968725443, 0.0018823054851964116, -0.008309667930006981, -0.01414421945810318, 0.00399140827357769, -0.0055625224485993385, -0.02013157494366169, 0.0042798276990652084, -0.02504151314496994, -0.018415814265608788, -0.007612209767103195, -0.005661980714648962, -0.0034615439362823963, -0.013171697966754436, 0.03811005502939224, 0.005407226271927357, -0.0051656016148626804, -0.07443373650312424, 0.0020728064700961113, -0.001473624142818153, -0.007928776554763317, -0.01886371336877346, 0.008142891339957714, -0.011255375109612942, 0.021233122795820236, -0.028408469632267952, -0.01267150230705738, 0.023048751056194305, -0.01960057206451893, 0.04393559694290161, -0.011537238024175167, 0.015938928350806236, 0.00008962068386608735, 0.0028556694742292166, 0.008049026131629944, -0.018903303891420364, 0.0033472864888608456, -0.00863328855484724, -0.0012600604677572846, -0.023801418021321297, -0.024266045540571213, -0.002947711618617177, -0.08024349808692932, 0.01924385502934456, -0.0034599811770021915, -0.005239531863480806, -0.01805736869573593, -0.014272033236920834, -0.00810257624834776, -0.003251864807680249, -0.014818869531154633, -0.01549606490880251, 0.01841338537633419, -0.010043094865977764, 0.022744648158550262, -0.0028950509149581194, 0.022168295457959175, -0.006659448146820068, 0.01971130259335041, -0.0054428596049547195, -0.03588008135557175, 0.022008582949638367, -0.010549904778599739, -0.008719156496226788, -0.0074356854893267155, -0.0120474174618721, -0.01011061854660511, 0.012852131389081478, -0.029779735952615738, 0.014917250722646713, -0.012548806145787239, -0.006402027327567339, -0.010767349041998386, -0.006405682768672705, -0.003093251958489418, -0.00883546844124794, -0.03581070527434349, -0.012088858522474766, -0.011503511108458042, -0.0554339736700058, 0.0003194934397470206, 0.005385002586990595, -0.009708489291369915, -0.007169957738369703, -0.004445224534720182, 0.0066063543781638145, 0.032954324036836624, 0.011717158369719982, 0.009024799801409245, -0.015455618500709534, 0.00408314960077405, -0.018931543454527855, 0.015656225383281708, 0.01197108905762434, -0.003791408147662878, 0.012736224569380283, -0.026002896949648857, 0.005174145568162203, -0.0007661653216928244, 0.031135501340031624, -0.01472912635654211, 0.0060346731916069984, -0.011339844204485416, 0.011832930147647858, 0.003599325194954872, 0.07112865149974823, -0.02030997909605503, -0.011712013743817806, 0.019583430141210556, -0.010392808355391026, 0.0011584347812458873, 0.008797536604106426, -0.03799960017204285, 0.002624903805553913, 0.012895312160253525, -0.03056466579437256, 0.005653679370880127, -0.030567003414034843, 0.013792886398732662, 0.0234186090528965, 0.019513435661792755, -0.04084785655140877, 0.023732759058475494, -0.00015371253539342433, -0.0029334239661693573, 0.0006257714121602476, 0.018123885616660118, -0.019722510129213333, -0.006514639127999544, 0.025565553456544876, -0.0024896899703890085, 0.010456569492816925, 0.03189723566174507, -0.007312726695090532, 0.01872038096189499, -0.02405392751097679, -0.029110636562108994, 0.008864974603056908, 0.0012280225055292249, 0.011180304922163486, 0.023832831531763077, 0.0034923723433166742, 0.007950849831104279, -0.022421875968575478, -0.024399109184741974, -0.006373189855366945, -0.00864177756011486, 0.00003969858880736865, -0.02799590490758419, 0.012495636940002441, -0.02800329402089119, 0.00034527454408816993, 0.007616337854415178, -0.003410601057112217, 0.006067459937185049, 0.03036865033209324, 0.014503732323646545, -0.0025444256607443094, -0.017187021672725677, 0.013041931204497814, 0.007714700419455767, 0.004324490670114756, 0.031060490757226944, -0.010540097020566463, 0.006715310271829367, 0.009736694395542145, -0.01133944932371378, 0.007309793494641781, -0.020108148455619812, 0.007562628015875816, -0.014157303608953953, 0.013200041837990284, -0.01551392488181591, 0.0229784082621336, 0.01115389633923769, -0.008265232667326927, 0.02961801178753376, 0.006927140988409519, 0.0023772334679961205, 0.005500126630067825, -0.00005564825551118702, 0.019814111292362213, 0.020390303805470467, 0.016492249444127083, 0.028055263683199883, -0.007373983971774578, 0.010563717223703861, -0.016640910878777504, 0.011508309282362461, -0.010755856521427631, -0.009274482727050781, 0.013534869067370892, 0.019499005749821663, 0.0006215949542820454, 0.006598727777600288, 0.024440929293632507, 0.009780009277164936, -0.002126948442310095, 0.011348282918334007, 0.0060623339377343655, 0.03627937659621239, 0.010897352360188961, 0.00812508910894394, 0.012890847399830818, 0.0015595672884956002, 0.011756498366594315, 0.015369877219200134, -0.01658804714679718, 0.0026037280913442373, -0.009840539656579494, -0.0115490248426795, -0.007445124909281731, 0.013291497714817524, 0.03252556174993515, -0.012456799857318401, -0.0014068481978029013, 0.01055088359862566, 0.02973921224474907, -0.02132718823850155, 0.008115937002003193, 0.03715284541249275, -0.028281718492507935, 0.005016636569052935, 0.00039575391565449536, -0.008954636752605438, 0.017618615180253983, -0.011717836372554302, -0.010526143945753574, 0.01800762303173542, 0.03492380306124687, -0.017036620527505875, -0.007892156019806862, 0.0013710581697523594, -0.009102113544940948, 0.009410364553332329, 0.01779765635728836, 0.00030063901795074344, 0.010057213716208935, 0.02202454023063183, -0.027271810919046402, -0.057225875556468964, -0.0027835112996399403, 0.011082328855991364, 0.00018405051378067583, 0.01437818631529808, 0.010225530713796616, -0.0016079184133559465, 0.007971293292939663, -0.015008090063929558, 0.010637753643095493, -0.028286967426538467, -0.025789955630898476, 0.022739790380001068, 0.009751447476446629, -0.002338310005143285, 0.030817275866866112, 0.025030650198459625, 0.0075409915298223495, -0.009210264310240746, -0.0403669998049736, 0.005380446556955576, -0.002873149933293462, -0.032658107578754425, 0.011682499200105667, 0.005588378757238388, 0.001480917097069323, 0.011693953536450863, -0.011826436035335064, -0.014338018372654915, 0.02080465853214264, 0.041313815861940384, -0.019067401066422462, -0.018855225294828415, 0.007407937198877335, -0.05802883207798004, -0.005191761068999767, -0.014410462230443954, -0.001841757562942803, 0.029966911301016808, -0.03758591040968895, -0.0006876754923723638, -0.0007110601291060448, 0.0011924641439691186, -0.014326285570859909, 0.010622303001582623, 0.0020161487627774477, 0.02637733891606331, 0.016244573518633842, -0.00826520100235939, 0.0080615459010005, 0.006615090649574995, -0.00429318193346262, -0.005998530425131321, 0.00006911498348927125, 0.03965238854289055, -0.023233547806739807, -0.028287289664149284, -0.025921206921339035, 0.011249651201069355, 0.003126598661765456, 0.009655087254941463, -0.009520534425973892, 0.009464136324822903, 0.012261764146387577, 0.0006126225343905389, -0.0043426095508039, -0.01546290423721075 ]
[ 0.00561721995472908, -0.0613592304289341, -0.1971539855003357, -0.09655614197254181, 0.15319320559501648, 0.47515565156936646, 0.13129054009914398, -0.5003688931465149, 0.041016727685928345, -0.1033506765961647, 0.12996859848499298, -0.12656961381435394, -0.15704651176929474, 0.25737252831459045, -0.060312941670417786, 0.44999369978904724, 0.4354037642478943, 0.5513886213302612, 0.06973318010568619, -0.9362151026725769, -0.22419652342796326, -0.8711777925491333, 0.4255951941013336, 0.37515926361083984, -0.13178379833698273, 0.11548572033643723, 0.625485897064209, 0.029092079028487206, 0.05972135066986084, -0.1984981745481491, 0.011000177823007107, 0.551811158657074, 0.41080495715141296, -0.37601399421691895, -0.017479069530963898, 0.1305461823940277, -0.1394483596086502, -0.1301916539669037, -0.024821029976010323, -0.5388171672821045, -0.3452296853065491, -0.24178990721702576, -0.10801312327384949, 0.5190691947937012, -0.37548914551734924, -0.18085341155529022, -0.5765578150749207, 1.1085792779922485, -0.11371830105781555, 0.2889018952846527, -0.03291425108909607, -0.04831310361623764, 0.37905967235565186, 0.20168034732341766, -0.13989457488059998, 0.32979097962379456, -0.7853026986122131, 0.14050012826919556, -0.062221918255090714, -0.07449620217084885, 0.5309962630271912, -0.4548570513725281, 0.4187820255756378, 0.24617816507816315, 0.07801806181669235, 0.36488842964172363, 0.25194889307022095, -0.04835737124085426, 0.2844035029411316, -0.16578100621700287, 0.008789179846644402, 0.11349383741617203, -0.47079408168792725, 0.2507692873477936, -0.18994052708148956, 0.21431566774845123, -0.5575101971626282, -0.3382255434989929, 0.43100133538246155, -0.24406616389751434, 0.11112852394580841, -0.17966783046722412, -0.010401944629848003, -0.056771472096443176, 0.13625164330005646, 0.45563891530036926, 0.22303113341331482, 0.11364226788282394, -0.33761152625083923, 0.5223779082298279, -0.3223191797733307, 0.1951068490743637, 0.5722231864929199, 0.5009135007858276, -0.03943856433033943, 0.2995698153972626, -0.11085572093725204, -0.08546749502420425, 0.19607675075531006, -0.22451944649219513, -0.26601213216781616, 0.32553887367248535, 0.05514112859964371, -0.4666436016559601, -0.4023944139480591, -0.27528315782546997, -0.13927394151687622, -0.7700415849685669, -0.23118934035301208, -0.04829026758670807, -0.30500784516334534, -0.3180239796638489, -0.00723030511289835, -0.058685991913080215, 0.05809192731976509, 0.3471356928348541, 0.17035633325576782, -0.1602335423231125, 0.18349313735961914, -0.0014128750190138817, -0.7089510560035706, 0.5484707951545715, -0.39012110233306885, -0.05433919280767441, -0.07789570838212967, -0.19031381607055664, 0.6013067960739136, -0.11372704803943634, 0.14877760410308838, 0.6931959986686707, -0.24011480808258057, 0.6644541621208191, 0.10076729953289032, 0.20008403062820435, -0.4220585227012634, -0.16116301715373993, -0.20492708683013916, 0.3516519367694855, 0.05649705231189728, 0.37544435262680054, -0.17566609382629395, -0.7448481321334839, -0.22681477665901184, -0.21812497079372406, 0.269807904958725, -0.3568893074989319, 0.24562367796897888, 0.04405668005347252, -0.38866737484931946, 0.06811415404081345, -0.010984610766172409, 0.04802069440484047, 0.10391831398010254, -0.4935057461261749, 0.6584739089012146, 0.1800214648246765, -0.469683438539505, 0.012530400417745113, 0.2656462788581848, -0.0671842023730278, 0.5111303925514221, 0.491627037525177, -0.20592299103736877, 0.16293475031852722, -0.08939522504806519, 0.08351469039916992, 0.6624504327774048, 0.6646128296852112, -0.5200555920600891, 0.0247043389827013, -0.4244399964809418, -0.4055308997631073, -0.0020660567097365856, 0.002379963407292962, -0.4706243872642517, -0.0031362718436867, 0.3370994031429291, 0.05749201402068138, 0.1851452738046646, -0.1624452769756317, -0.3393069803714752, 0.23696552217006683, -0.21370670199394226, 0.06396470963954926, 0.7529908418655396, 0.10764671862125397, 0.2022908627986908, 0.02244153432548046, -0.3013233244419098, 0.05444101244211197, 0.31231075525283813, -0.4027569591999054, 0.6888064742088318, -0.14813534915447235, 1.0628960132598877, -0.4999017119407654, 0.1729622483253479, 1.0436382293701172, 0.2341095209121704, -0.267759770154953, -0.6371539235115051, 0.5006242990493774, 0.5947278141975403, -0.332854688167572, -0.3671848475933075, -0.14566196501255035, -0.3131536841392517, -0.42635947465896606, 0.12202142924070358, 0.27418291568756104, -0.28082945942878723, -0.12710405886173248, 0.12989819049835205, 0.219651997089386, 0.0564829483628273, 0.06667768955230713, 0.22029274702072144, 0.3107061982154846, 0.1629762202501297, -0.05994164198637009, 0.5756720304489136, -0.3415502905845642, 0.5676164031028748, 0.45463258028030396, -0.23872511088848114, 0.16271141171455383, 0.6204497814178467, 0.35957425832748413, 0.3260401785373688, -0.3355489671230316, 0.19787812232971191, -0.2955302298069, 0.6441951990127563, 0.21387596428394318, -0.3509422242641449, -0.0500880628824234, -0.09260443598031998, -0.29938599467277527, -0.24750694632530212, 0.15049684047698975, 0.08578231185674667, 0.5766752362251282, -0.31285691261291504, -0.006789083126932383, 0.023326175287365913, -0.3675554692745209, -0.11096307635307312, 0.3972429633140564, -0.9705110788345337, -0.17674361169338226, 0.08987569808959961, 0.4963846206665039, 0.12208418548107147, 0.10065464675426483, 0.17078861594200134, -0.3062922954559326, 0.017677193507552147, -0.5982263684272766, 0.17327402532100677, -0.48855704069137573, 0.22186483442783356, -0.16301429271697998, 0.4090115427970886, -0.0012764111161231995, 0.23503737151622772, -0.6140810251235962, -1.1762977838516235, -0.7451131939888, 0.7183894515037537, 0.44056710600852966, 0.9914378523826599, 0.5343268513679504, -0.7684851884841919, 0.15797710418701172, 0.6702765822410583, -0.5107845067977905, -0.28590136766433716, -0.11747540533542633, -0.3261883556842804, -0.09448433667421341, -0.17790487408638, 0.2807443141937256, 0.5177285671234131, -0.2148122638463974, 0.027952471747994423, -0.09705622494220734, -0.07519176602363586, -0.7482971549034119, -0.00403545843437314, -0.40807411074638367, 0.1611981987953186, 0.29649877548217773, -0.2120770364999771, -0.5194759368896484, 0.11568576842546463, 0.01702982187271118, -0.13938911259174347, 0.8476697206497192, 0.54006427526474, 0.2467852085828781, -0.13005821406841278, 0.1638004332780838, 0.08386445045471191, 0.1392209678888321, 0.059026215225458145, 0.03485079109668732, 0.03833473101258278, -0.022573858499526978, -6.059593200683594, 0.5451354384422302, -0.42622053623199463, -0.45647963881492615, 0.19474120438098907, 0.2673422396183014, 0.6497287750244141, -0.32521089911460876, -0.01994190737605095, 0.24703560769557953, 0.3880116641521454, 0.2535059154033661, 0.1620551198720932, -0.39154401421546936, 0.1770295649766922, -0.13425582647323608, -0.18175335228443146, -0.43368226289749146, 0.3489864766597748, -0.027321627363562584, 0.25957491993904114, -0.4652308523654938, -0.4307999908924103, 0.3262098729610443, 0.1489822119474411, 0.14278292655944824, -0.5442564487457275, -0.38262322545051575, -0.3896513283252716, -0.26852723956108093, -0.317833811044693, -0.7761532664299011, -0.5908570289611816, 0.1900879293680191, 0.5304526090621948, 0.18931125104427338, 0.3297949731349945, 0.004966889042407274, 0.12643788754940033, -0.39079323410987854, 0.2715523838996887, 0.024058230221271515, -0.18363459408283234, -0.30535000562667847, 0.05045229569077492, 0.24427750706672668, -0.14769504964351654, 0.29528725147247314, -0.023962803184986115, 0.29733145236968994, -0.11968709528446198, -0.17696493864059448, -0.057781882584095, 0.5906417965888977, 0.03992531821131706, 0.2823128402233124, -0.12343574315309525, 0.13858208060264587, -0.5247687101364136, 0.06426175683736801, -0.20435963571071625, -0.1004210114479065, 0.06577397137880325, -0.4617157578468323, 0.16059182584285736, 0.08107626438140869, -0.8036211133003235, -0.13595175743103027, 0.03034139797091484, 0.47930964827537537, -0.1363738775253296, 0.12177878618240356, 0.10046222805976868, -0.8860386610031128, 0.4651872217655182, -1.017540693283081, 0.38431495428085327, 0.11637735366821289, -0.30771884322166443, -0.08723790943622589, -0.0754341408610344, -0.4124235212802887, 0.18517397344112396, 0.0028165639378130436, 0.24200235307216644, -0.3121427297592163, -0.2502114176750183, -0.21947546303272247, -0.1538953185081482, -0.2256084680557251, 0.28817319869995117, -0.36934173107147217, 0.03501884639263153, 0.7071297764778137, 0.17921681702136993, 0.19546113908290863, 0.14843584597110748, 0.5316318869590759, 0.4956527352333069, 0.22464369237422943, 1.0037858486175537, 0.19155780971050262, -0.45841142535209656, -0.9324932098388672, -0.5991431474685669, 0.12954966723918915, -0.6378487944602966, 0.18195530772209167, 0.491129994392395, -0.8020613193511963, 0.03148423507809639, -0.2714003324508667, 0.31534886360168457, -0.3112473487854004, 0.7562751770019531, 0.04325852543115616, 0.13267798721790314, 0.33804839849472046, 0.9027661085128784, 0.24832725524902344, 0.5305407047271729, -0.0944359302520752, -1.0290215015411377, 0.44719675183296204, 0.4309300482273102, -0.3798861801624298, 0.22310827672481537, 0.3741319179534912, -0.999363124370575, -0.2679109275341034, 0.19836345314979553, 0.11105936765670776, -0.15429575741291046, -0.16748085618019104, 0.044267747551202774, -0.14750908315181732, -0.8951550722122192, 0.15804216265678406, 0.16213129460811615, 0.22437109053134918, -0.11767596006393433, 0.33834218978881836, -0.07305111736059189, -0.029106933623552322, -0.5790602564811707, -0.29889947175979614, 0.07999705523252487, -0.07852230221033096, -0.5435010194778442, -0.18563106656074524, 0.34837856888771057, -0.41939130425453186, 0.24163374304771423, 0.40042421221733093, -0.5694456696510315, -0.026188666000962257, 0.8159402012825012, 0.7187381982803345, 0.005107746925204992, -0.5457942485809326, -0.24296025931835175, 0.08009390532970428, -0.9705450534820557, 0.011211751960217953, -0.28424444794654846, -0.4250965416431427, 0.26087960600852966, -0.19935233891010284, -0.005879250820726156, 0.3534456491470337, -0.0609041191637516, -0.5089961290359497, 0.3680587410926819, -0.013361838646233082, 0.026919318363070488, 0.26464033126831055, -0.3720370829105377, -0.4228934049606323, -0.013788044452667236, 0.3907831311225891, -0.04743858426809311, -0.24151961505413055, -0.11924389004707336, 0.15396961569786072, 0.4911286234855652, 1.0581848621368408, -0.06671901047229767, -0.4558923840522766, 0.005000617820769548, 0.21935594081878662, 0.09339070320129395, -0.11507699638605118, 0.3123263716697693, -0.4615342319011688, -0.35445958375930786, 0.45222532749176025, 0.2095794975757599, 0.515174388885498, -0.19938048720359802, 0.10195375978946686, 0.09036915004253387, 0.5645629167556763, -0.19077132642269135, 0.08306490629911423, 0.5517674684524536, -0.16893479228019714, -0.1920822113752365, 0.021062657237052917, -0.6215048432350159, -0.20343002676963806, -0.200855553150177, -0.12913504242897034, -0.2825287878513336, 0.31423354148864746, -0.3265034556388855, 0.5812636613845825, -0.13192631304264069, -0.6606597304344177, -0.13397656381130219, 0.3555521070957184, -0.12622606754302979, 0.02374410070478916, -0.26721087098121643, -0.3100474178791046, -0.2201719880104065, -0.2641868591308594, 0.12036985903978348, -0.8214472532272339, 0.3246207535266876, 0.14968809485435486, -0.09542502462863922, -0.14548133313655853, -0.03279583528637886, 0.13735172152519226, -0.34988969564437866, -0.1880066841840744, -0.022240564227104187, -0.01810983009636402, -0.26681211590766907, 0.053360216319561005, 0.3590262830257416, 0.49909451603889465, 0.26969289779663086, 0.3464787006378174, 0.0043032001703977585, -0.22209349274635315, -0.05279994755983353, -0.4599456191062927, 0.11816159635782242, 0.1551661193370819, 0.1839638352394104, -0.3155713379383087, 0.2768053710460663, 0.23353318870067596, 0.7685659527778625, 0.4069491922855377, 0.4048934578895569, -0.7958557605743408, 0.09354158490896225, 0.17026503384113312, -0.2269509881734848, 0.21074311435222626, -0.1645340770483017, 0.25117596983909607, 0.032122425734996796, 0.3826885223388672, -0.33190375566482544, -0.4730062186717987, 0.4572325646877289, 0.21981213986873627, 0.3187667727470398, -0.12342991679906845, 0.04586035758256912, 0.13462260365486145, -0.18542829155921936, 0.5800799131393433, -0.1666174829006195, 0.20060096681118011, 0.09704439342021942, 0.27474573254585266, -0.3961142301559448, -0.2392006367444992, 0.5576430559158325, -0.08902114629745483, -0.037388209253549576, -0.41954705119132996, -0.5927246809005737, -0.2774299085140228, -0.10551613569259644, -0.10503742098808289, 0.16332943737506866, 0.14047302305698395, -0.6194716095924377, -0.2207210659980774, 0.25315427780151367, 0.44800737500190735, 0.4316238760948181, 0.6990766525268555, -0.1565633863210678, -0.24704228341579437, -0.6944549083709717, 0.7329608798027039, 0.5932605266571045, -0.0779256597161293, -0.16654956340789795, 0.2300700545310974, 0.2434699833393097, 0.2672469913959503, -0.528090238571167, -0.047812171280384064, 0.39717304706573486, -0.0569356307387352, 0.280935138463974, 0.06366943567991257, -0.8623649477958679, -0.21021293103694916, -0.2532038986682892, 0.14976079761981964, 0.03405369818210602, 0.0879242941737175, 0.36394694447517395, 0.5439848303794861, 0.40266790986061096, 0.06503220647573471, -0.19793172180652618, 0.40902015566825867, 0.3882805109024048, 0.30573537945747375, 0.3043063282966614, 0.49093857407569885, 0.3645837604999542, 0.11723994463682175, -0.22137847542762756, 0.24041521549224854, 0.2697544991970062, 0.18717427551746368, -0.2765117883682251, -0.28211984038352966, -0.13602185249328613, 0.49415716528892517, 0.7992303371429443, -0.18286673724651337, -0.14519788324832916, 0.054577577859163284, -0.04589467868208885, 0.25968137383461, -0.3396351933479309, -0.33823999762535095, -0.04379453510046005, -0.10639401525259018, 0.38861191272735596, -0.47968557476997375, -0.2929566204547882, 0.47016069293022156, -0.4215525984764099, 0.062135666608810425, 0.2791668176651001, -0.5320897102355957, -0.8743304014205933, -0.01617230847477913, -0.5846939086914062, 0.06650767475366592, -0.06707692891359329, 0.5290375351905823, 0.44089439511299133, -0.09105006605386734, 0.09435998648405075, 0.47599080204963684, 0.03988830745220184, -0.35375717282295227, -0.19135667383670807, -0.2144717276096344, -0.8373071551322937, -0.05203583464026451, 0.43514832854270935, -0.20406562089920044, -0.18264204263687134, -0.40805160999298096, -0.3391145169734955, 0.10164301097393036, -0.8789574503898621, -0.12308157980442047, -0.1274879276752472, -0.7727975249290466, -0.41286608576774597, 0.08931459486484528, -0.008015647530555725, -0.08905701339244843, 0.10580547153949738, 0.028612229973077774, 0.9039328098297119, -0.4344594478607178, 0.21181589365005493, 0.10785867273807526, -0.16487106680870056, -0.24955815076828003, 0.012169760651886463, -0.10708637535572052, 0.3515000343322754, 0.3034358620643616, -0.04660705476999283, -0.06880214065313339, -0.4959396421909332, 0.03180645406246185, -0.012575527653098106, 0.4432414174079895, -0.6988874077796936, 0.14585557579994202, -0.20161809027194977, -0.03757297992706299, 0.3749445974826813, 0.009198888204991817, -0.39467108249664307, 0.5216873288154602, 0.25200793147087097, 0.38896119594573975, 0.702435314655304, -0.726611316204071, -0.3622823655605316, -0.2000073343515396, -0.6844542622566223, -0.32478275895118713, 0.40702322125434875, 0.33373427391052246, -0.10100025683641434, 0.5684221982955933, 0.3612378239631653, 0.2086399644613266, -0.49255022406578064, 0.5564658641815186, -0.6198340654373169, 0.33932897448539734, -0.4373141825199127, -0.0519913025200367, -0.46250632405281067, -0.11241061240434647, 0.005148652009665966, -0.14341247081756592, 0.15823721885681152, 0.03320298716425896, 0.2067352682352066, -0.749207079410553, -0.06322058290243149, -0.031759269535541534, 0.11078330129384995, 0.0858408734202385, -0.004940446000546217, -0.5526946187019348, -0.552288830280304, 0.11025606095790863, -0.23866119980812073, 0.3006688058376312, -0.2013958990573883, 0.04878536984324455, -0.009898760356009007, -0.016204072162508965, -0.2129671573638916, -0.631074845790863, 0.2644466757774353, -0.025147289037704468 ]
Mutations or duplications in MECP2 cause Rett and Rett-like syndromes, neurodevelopmental disorders characterized by mental retardation, motor dysfunction, and autistic behaviors. MeCP2 is expressed in many mammalian tissues and functions as a global repressor of transcription; however, the molecular mechanisms by which MeCP2 dysfunction leads to the neural-specific phenotypes of RTT remain poorly understood. Here, we show that neuronal activity and subsequent calcium influx trigger the de novo phosphorylation of MeCP2 at serine 421 (S421) by a CaMKII-dependent mechanism. MeCP2 S421 phosphorylation is induced selectively in the brain in response to physiological stimuli. Significantly, we find that S421 phosphorylation controls the ability of MeCP2 to regulate dendritic patterning, spine morphogenesis, and the activity-dependent induction of Bdnf transcription. These findings suggest that, by triggering MeCP2 phosphorylation, neuronal activity regulates a program of gene expression that mediates nervous system maturation and that disruption of this process in individuals with mutations in MeCP2 may underlie the neural-specific pathology of RTT.
[ -0.014451595023274422, -0.0006975470460020006, -0.018167942762374878, 0.013281306251883507, -0.0032787644304335117, -0.027050042524933815, 0.011334666982293129, 0.006261688657104969, -0.012474940158426762, 0.009241792373359203, -0.02147705852985382, 0.008146701380610466, 0.01255019847303629, 0.01444597914814949, -0.010862629860639572, 0.02099825069308281, -0.01919584721326828, 0.03553345054388046, 0.0053779613226652145, 0.03073778934776783, -0.013434326276183128, 0.005314329639077187, 0.011281885206699371, 0.02520073764026165, 0.00635062251240015, -0.000684699509292841, 0.013643416576087475, 0.004979920107871294, -0.010767662897706032, 0.0019664857536554337, -0.01606321707367897, 0.014032797887921333, 0.016687799245119095, 0.026477240025997162, -0.0015663409139961004, 0.007978654466569424, -0.006517517380416393, 0.021518699824810028, 0.040060192346572876, -0.0052554733119904995, -0.013209022581577301, -0.008384664542973042, 0.0025799418799579144, -0.030620072036981583, -0.00507869990542531, -0.008055154234170914, 0.004619601182639599, 0.006822269409894943, -0.022458471357822418, 0.0037629478611052036, -0.01646425575017929, 0.028026100248098373, -0.00982855074107647, 0.030883992090821266, -0.006630197167396545, 0.0022087786346673965, 0.018718259409070015, 0.02132519707083702, 0.03224729746580124, 0.0018053068779408932, 0.03390437737107277, 0.017581094056367874, -0.017876744270324707, -0.012858299538493156, 0.014844262972474098, -0.06662680953741074, -0.00507175549864769, 0.007884024642407894, 0.003580664284527302, 0.020791329443454742, -0.023828741163015366, 0.007623939774930477, -0.01270898338407278, 0.01679059863090515, 0.01590821146965027, -0.015552395954728127, -0.010864179581403732, 0.004387473687529564, 0.010616505518555641, 0.025049984455108643, 0.00809067115187645, -0.035464461892843246, 0.039700355380773544, 0.01835208386182785, 0.0051940130069851875, -0.007529504597187042, -0.01603451743721962, -0.016660571098327637, -0.0016957949846982956, 0.006726971827447414, 0.0102503951638937, -0.0029221195727586746, 0.012228401377797127, -0.006318077445030212, -0.04139479249715805, -0.021332047879695892, 0.013948244974017143, 0.005048798862844706, 0.002399388700723648, -0.001005820231512189, -0.014044702053070068, 0.001740654930472374, 0.023953523486852646, 0.005688061937689781, 0.002317246049642563, 0.012493852525949478, -0.004592474550008774, -0.004193306900560856, 0.011159119196236134, 0.020947139710187912, -0.0016186102293431759, 0.008693528361618519, -0.0022032614797353745, 0.02082563005387783, 0.003132178448140621, -0.0050324946641922, 0.016034739091992378, -0.006226171273738146, 0.024156946688890457, -0.019951244816184044, -0.0045213280245661736, 0.0036814238410443068, 0.00044401828199625015, 0.010600714944303036, 0.007605096325278282, 0.014333859086036682, 0.010915800929069519, 0.027102967724204063, -0.005787484347820282, 0.014692152850329876, -0.009092873893678188, 0.009526578709483147, -0.004741049837321043, 0.025047577917575836, 0.004877923056483269, -0.009090863168239594, -0.0010811155661940575, -0.01883758418262005, 0.007318622432649136, -0.014651463367044926, 0.02052321657538414, 0.007983705028891563, 0.007674134336411953, 0.012275529094040394, 0.004255637060850859, 0.006541271228343248, 0.023007474839687347, 0.015482921153306961, 0.004816744942218065, -0.023234091699123383, 0.019208384677767754, -0.006366768851876259, -0.030902348458766937, -0.016555482521653175, 0.017395783215761185, 0.04801703244447708, -0.018528394401073456, 0.007555000949651003, 0.0011431323364377022, 0.062359705567359924, -0.014373518526554108, -0.016562707722187042, 0.038643550127744675, 0.010479798540472984, -0.0015997003065422177, 0.009947524406015873, -0.020483473315835, -0.019544532522559166, -0.014375641942024231, 0.0033081420697271824, 0.004775518551468849, -0.028027087450027466, 0.004795685410499573, 0.0025890711694955826, -0.013506323099136353, -0.007269468158483505, -0.0011743884533643723, 0.007375242188572884, -0.021025771275162697, 0.06674180924892426, 0.02452121488749981, -0.015569930896162987, 0.0054143210873007774, 0.024502333253622055, -0.005513748619705439, -0.019284488633275032, 0.03900628164410591, -0.0023567865137010813, -0.019578076899051666, -0.01740570366382599, 0.02513301558792591, 0.012677864171564579, -0.025354918092489243, 0.021370714530348778, 0.016181737184524536, 0.0037404207978397608, 0.006957351695746183, 0.0091922078281641, 0.023539215326309204, -0.012546844780445099, -0.002216463442891836, 0.011609559878706932, -0.0045941062271595, -0.011608152650296688, 0.009504524990916252, 0.014843171462416649, 0.03821009024977684, 0.005896279588341713, 0.005246367305517197, -0.00653473474085331, 0.012017099186778069, -0.0071692089550197124, -0.012602371163666248, 0.0013926003593951464, 0.008882236666977406, 0.009631366468966007, 0.009301276877522469, 0.021287836134433746, -0.003946245647966862, -0.01289684884250164, -0.007776608690619469, -0.002339184284210205, 0.014389903284609318, -0.024780020117759705, 0.016690373420715332, 0.012564754113554955, -0.011899618431925774, 0.009824559092521667, 0.008458338677883148, 0.016942903399467468, -0.008865131065249443, -0.034854769706726074, -0.010765956714749336, 0.01727624237537384, 0.007837124168872833, -0.026197213679552078, 0.01662878692150116, 0.007866746746003628, 0.03194392845034599, -0.014614541083574295, -0.025447465479373932, -0.021130140870809555, 0.028177758678793907, -0.025761853903532028, 0.012386036105453968, -0.008137491531670094, 0.02188916504383087, 0.00453172018751502, -0.006762589793652296, -0.0062386654317379, 0.009400752373039722, -0.02062615007162094, 0.04528535529971123, -0.013587947003543377, -0.006765573285520077, -0.02222757413983345, -0.009935835376381874, 0.01126902550458908, 0.025097813457250595, 0.009378609247505665, 0.002386323641985655, 0.00954502634704113, -0.01597442664206028, 0.03606387972831726, -0.018014680594205856, -0.013477512635290623, 0.020581254735589027, 0.002816796535626054, 0.009910861030220985, 0.023748274892568588, 0.0067603434436023235, -0.010272588580846786, -0.008836181834340096, -0.08126772940158844, -0.012281467206776142, 0.004524581599980593, 0.004009664990007877, 0.005933452397584915, -0.027539867907762527, -0.013227501884102821, -0.007795420940965414, -0.01171645987778902, 0.004329683259129524, 0.009383920580148697, -0.010097471997141838, -0.008474050089716911, 0.005760298576205969, -0.00790729746222496, -0.012356472201645374, 0.02370140329003334, 0.02706966921687126, -0.011211610399186611, 0.006333936005830765, 0.034350186586380005, -0.0073072584345936775, 0.0175351370126009, 0.007725741248577833, -0.040230393409729004, -0.003745818277820945, 0.023615503683686256, 0.014798995107412338, -0.026226839050650597, 0.008394693024456501, -0.0021577123552560806, 0.005431428551673889, 0.0035184198059141636, -0.0024916105903685093, -0.01815640553832054, 0.0031719300895929337, -0.024306997656822205, 0.005819701123982668, 0.0013524189125746489, 0.016621824353933334, -0.027414537966251373, 0.002866368507966399, 0.013304976746439934, 0.0035439468920230865, 0.004091356880962849, 0.02608027309179306, 0.03523466736078262, -0.023862699046730995, 0.017791053280234337, 0.010466440580785275, -0.003571357112377882, 0.00908361654728651, -0.01967044547200203, 0.010736986063420773, -0.010665882378816605, -0.0012314817868173122, -0.012283828109502792, -0.019971203058958054, -0.005698264576494694, 0.0028490680269896984, 0.013731031678617, -0.008207126520574093, 0.028910700231790543, 0.011862147599458694, 0.010187177918851376, -0.008713886141777039, 0.010911209508776665, -0.032774847000837326, -0.013336188159883022, -0.0022322642616927624, -0.0030135028064250946, 0.021260106936097145, -0.005108576267957687, 0.0012492660898715258, -0.010999253019690514, -0.011707162484526634, -0.010108006186783314, 0.00007401581387966871, 0.03100397065281868, -0.039461344480514526, -0.045560937374830246, -0.005655547603964806, -0.002398480661213398, -0.003963872790336609, -0.0182049497961998, -0.0033227140083909035, 0.0062612509354949, 0.03763313591480255, 0.022123955190181732, -0.014600396156311035, 0.011797146871685982, 0.022635942324995995, -0.011893991380929947, 0.013401107862591743, -0.022570554167032242, -0.011637622490525246, 0.015501787886023521, -0.0061323512345552444, 0.03132491931319237, 0.008633813820779324, -0.0034089861437678337, 0.001956869615241885, 0.0025800103321671486, -0.005601901561021805, 0.0057633183896541595, 0.010161332786083221, -0.0105406129732728, -0.010740170255303383, -0.01627717912197113, -0.0034668019507080317, -0.0117978285998106, -0.03267059847712517, -0.0018668313277885318, 0.006361895706504583, 0.011931240558624268, 0.03475138545036316, 0.0034314484801143408, -0.01775805652141571, 0.07142564654350281, -0.017144937068223953, 0.002107728272676468, -0.02017180807888508, 0.0131960678845644, -0.049917660653591156, 0.003228855086490512, 0.01453719288110733, -0.0017856091726571321, 0.020237179473042488, 0.01373220793902874, 0.021992074325680733, 0.03449830412864685, -0.006098623387515545, -0.04283253103494644, 0.008012626320123672, 0.005404552444815636, 0.00858159177005291, 0.05049784481525421, 0.010490220040082932, 0.04242641478776932, -0.03465452045202255, 0.0017454596236348152, 0.0007416633889079094, -0.007550458423793316, 0.004347204230725765, 0.005003549158573151, -0.015826426446437836, -0.0070875948294997215, 0.012040290981531143, 0.035117439925670624, 0.001510711619630456, -0.011014318093657494, 0.003843250684440136, 0.01834145374596119, -0.0053848219104111195, 0.021593570709228516, -0.011718071065843105, 0.00041196309030056, 0.002892338205128908, -0.0018691858276724815, -0.014022298157215118, 0.030441701412200928, 0.01276834961026907, 0.004740292206406593, -0.020858274772763252, 0.07553297281265259, -0.010956428945064545, -0.00357650825753808, -0.000357702374458313, -0.008921884000301361, -0.003083022078499198, 0.01263365987688303, -0.007830293849110603, 0.01711532659828663, -0.023397449404001236, 0.02726500667631626, -0.0057009304873645306, 0.010992931202054024, -0.029604004696011543, -0.005587170831859112, -0.014285240322351456, -0.027193956077098846, -0.021632781252264977, 0.014638768509030342, -0.02369033172726631, -0.013475950807332993, 0.014992829412221909, 0.012583195231854916, -0.0008060296531766653, -0.009220227599143982, -0.026776151731610298, -0.010973848402500153, -0.002701441291719675, -0.029603032395243645, 0.03543843328952789, -0.00010990002192556858, 0.035115912556648254, 0.03802930936217308, -0.036660149693489075, -0.013560610823333263, -0.012445934116840363, -0.008796180598437786, -0.00922265462577343, 0.04483667016029358, 0.017564022913575172, -0.020162977278232574, -0.07392510771751404, -0.012386763468384743, -0.02421395853161812, -0.002801358699798584, 0.0145459258928895, 0.005411896388977766, -0.013538322411477566, -0.019208604469895363, 0.026020027697086334, 0.004580285865813494, -0.012435738928616047, -0.023934710770845413, -0.03288774564862251, -0.01412298996001482, 0.009536519646644592, -0.006637277081608772, 0.02152879536151886, 0.012640116736292839, -0.003060115734115243, -0.006226888857781887, 0.009504511952400208, -0.009568112902343273, 0.001078454777598381, 0.007501203566789627, -0.005956926383078098, -0.08027979731559753, -0.01298127043992281, 0.003868676722049713, 0.011897450312972069, -0.028498578816652298, -0.003482617437839508, 0.02576826699078083, -0.01203542947769165, -0.025578703731298447, -0.017082955688238144, -0.026057738810777664, 0.017920203506946564, 0.0035771618131548166, -0.003221237799152732, 0.05110786855220795, -0.011492096818983555, -0.0018423842266201973, 0.006423889193683863, -0.019589394330978394, -0.0173106137663126, -0.02624399960041046, -0.007878610864281654, -0.009583059698343277, -0.013802986592054367, -0.011429594829678535, -0.01021958515048027, -0.03955704718828201, 0.016990801319479942, 0.000999685376882553, 0.006895206868648529, -0.01735842600464821, -0.01427672989666462, -0.01920684427022934, -0.0245622880756855, 0.008893141523003578, -0.02126205340027809, 0.008349424228072166, -0.003831031732261181, 0.0001901993528008461, -0.015709981322288513, -0.0040548983961343765, 0.013280189596116543, 0.0024471627548336983, 0.0007318591233342886, -0.01566508784890175, -0.014232700690627098, 0.0065905204974114895, -0.009702600538730621, 0.016307856887578964, 0.012542018666863441, 0.006649017333984375, -0.00670117512345314, -0.022826116532087326, 0.032166484743356705, 0.015571022406220436, -0.00747489370405674, -0.006653726100921631, 0.011075392365455627, 0.04065915569663048, 0.005075714085251093, 0.010417474433779716, 0.01656924933195114, -0.0012393828947097063, 0.07167107611894608, -0.029168151319026947, 0.03713569417595863, -0.0421314537525177, 0.015844864770770073, 0.004896974191069603, -0.02031688764691353, -0.0009323544800281525, -0.005312437191605568, -0.010143398307263851, 0.0203023049980402, -0.023964017629623413, 0.022632643580436707, 0.011302728205919266, -0.001212114468216896, -0.012274650856852531, -0.004653526935726404, -0.010893342085182667, 0.007495914585888386, 0.007766423746943474, 0.02804652601480484, 0.005665863398462534, -0.015180036425590515, 0.010562777519226074, 0.03135863319039345, 0.007534499280154705, -0.0025440589524805546, 0.008682305924594402, -0.01449877955019474, 0.02153034880757332, -0.0021944167092442513, 0.011069441214203835, 0.000049344904255121946, 0.004374067764729261, 0.010577073320746422, 0.035039931535720825, 0.0008072433993220329, 0.015486041083931923, -0.0314989909529686, 0.00005739089101552963, -0.015357441268861294, 0.009896604344248772, 0.007485677022486925, 0.002067898865789175, 0.002965180668979883, 0.003588356077671051, 0.025505932047963142, -0.03178883343935013, 0.030996084213256836, -0.0009034706745296717, -0.004619038663804531, 0.0013123955577611923, 0.0036882124841213226, 0.005676587577909231, 0.027878854423761368, -0.012273701839148998, -0.03389483690261841, 0.01196540892124176, -0.014724443666636944, -0.005946036893874407, -0.004478259012103081, 0.0018002568976953626, -0.014591464772820473, -0.021410472691059113, 0.028231695294380188, 0.023274708539247513, -0.013055703602731228, -0.02287033386528492, 0.022148754447698593, 0.0167403481900692, -0.025866732001304626, -0.019154304638504982, 0.009945504367351532, 0.01155963446944952, 0.041686076670885086, 0.03133820742368698, -0.013982793316245079, -0.023358654230833054, 0.029378365725278854, 0.018942561000585556, -0.012219292111694813, 0.033128172159194946, -0.014627774246037006, 0.013746429234743118, -0.003473312593996525, 0.0027607609517872334, 0.013031021691858768, -0.0033740096259862185, 0.004497256129980087, 0.012207121588289738, 0.025326170027256012, -0.00739974994212389, 0.004906522575765848, 0.019188232719898224, 0.014084842056035995, 0.03431812301278114, 0.01544528640806675, 0.011793944984674454, -0.008248801343142986, 0.01357715018093586, 0.03811122477054596, 0.0081182811409235, -0.004121551755815744, 0.0153281819075346, -0.013147668913006783, 0.00003408436896279454, -0.00882810354232788, 0.010262456722557545, 0.004701082594692707, 0.00946514867246151, 0.01263069175183773, 0.005348093342036009, 0.0036441078409552574, 0.03237038850784302, 0.0007394012063741684, -0.002523324452340603, 0.007031297776848078, 0.010058396495878696, 0.014365311712026596, -0.014349183067679405, -0.003929840866476297, 0.01430821605026722, -0.006201114505529404, 0.017888909205794334, 0.009388381615281105, -0.013840960338711739, -0.019839823246002197, 0.022092262282967567, 0.013627465814352036, 0.0114123011007905, 0.010777091607451439, 0.000615190714597702, 0.006218870636075735, 0.00350133515894413, 0.015258152037858963, 0.011033421382308006, 0.021375451236963272, -0.001814013347029686, -0.009804739616811275, 0.01979086734354496, 0.024982139468193054, -0.012264619581401348, -0.004346180707216263, 0.00782984122633934, 0.006790401414036751, -0.03141782432794571, -0.006861471571028233, 0.021349575370550156, 0.003573175286874175, 0.00029811286367475986, 0.017587335780262947, 0.008722249418497086, -0.003667279612272978, -0.011182872578501701, 0.019273748621344566, 0.03188265860080719, 0.0170096717774868, -0.03018879145383835, -0.009476622566580772, 0.0006313207559287548, -0.0006428253836929798, -0.00022803526371717453, 0.01334437821060419, 0.01239512488245964, -0.005970345810055733, 0.0015395982190966606, -0.03697476536035538, 0.03161729872226715, -0.020533116534352303, -0.03895461931824684, 0.022459208965301514, 0.002333275740966201, -0.018444418907165527, 0.024557217955589294, -0.004671808332204819, -0.018579762428998947, 0.00800545234233141, 0.01843339204788208, 0.01970542035996914, 0.020406587049365044, 0.017669694498181343, -0.01898178644478321, -0.004753401968628168, -0.009848156943917274, -0.005883501842617989, 0.011570161208510399, -0.0030602707993239164, -0.02040606364607811, -0.01711559295654297, -0.020762208849191666, -0.006420815363526344, -0.012571873143315315, -0.02618475630879402, 0.008302229456603527, -0.010653333738446236, -0.011494932696223259, 0.002702872036024928, -0.024610795080661774, 0.026223979890346527, -0.012272671796381474, 0.014336595311760902, -0.025376874953508377 ]
[ -0.26319578289985657, -0.21693862974643707, 0.2711709141731262, -0.1634756624698639, 0.07006009668111801, -0.2695159614086151, 0.44973304867744446, -0.1434035301208496, -0.17963244020938873, -0.5462295413017273, 0.05604187026619911, 0.2354109138250351, -0.4368782937526703, 0.24380561709403992, -0.14490140974521637, 0.7547968626022339, 0.5601820349693298, 0.48638615012168884, -0.5999051332473755, -0.8072454333305359, 0.11492367833852768, -0.009837032295763493, 0.3730844557285309, 0.26962950825691223, -0.12042318284511566, -0.16074711084365845, 0.2537499964237213, -0.2756648659706116, 0.6071577072143555, -0.2180844396352768, -0.40951985120773315, 0.26290807127952576, 0.33869868516921997, 0.13654471933841705, -0.3316376507282257, -0.11956412345170975, -0.7849643230438232, -0.10310309380292892, 0.17506755888462067, 0.44793933629989624, -0.2599678337574005, -0.4157244861125946, -0.4950064718723297, 0.46341758966445923, 0.23785535991191864, 0.17555145919322968, -1.638210654258728, 0.6246763467788696, -0.24379432201385498, 0.10493942350149155, -0.047189850360155106, 0.49939700961112976, 0.4399474263191223, 0.25011441111564636, 0.6769239902496338, 0.08462682366371155, -1.1339654922485352, -0.1158229187130928, 0.3434557616710663, -0.6391209363937378, -0.29465630650520325, -0.08899850398302078, -0.42033061385154724, 0.3703865706920624, -0.10390699654817581, 0.9591082334518433, -0.024587038904428482, -0.1554584503173828, -0.5226206183433533, -0.39073774218559265, 0.041070930659770966, -0.20481596887111664, -0.07977789640426636, 0.255463570356369, 0.0690067708492279, -0.40741604566574097, -0.6950754523277283, -0.3704674243927002, 0.3447003960609436, 0.27507585287094116, -0.17149440944194794, 0.2830946445465088, 0.40347400307655334, 0.0044578989036381245, 0.5112313032150269, 0.08073797821998596, 0.1084335520863533, 0.7769322395324707, -0.24086420238018036, -0.06970743089914322, 0.1694299578666687, -0.07514531165361404, 0.2308356612920761, 0.24841944873332977, 0.09838411211967468, 0.3374878764152527, -0.07055338472127914, 0.0023169275373220444, -0.3371694087982178, 0.34483107924461365, -0.00033811081084422767, 0.11251503974199295, 0.026770081371068954, -0.5895549058914185, -0.5165083408355713, -0.38949620723724365, -0.22412759065628052, -0.8362451195716858, -0.42999935150146484, 0.1651347130537033, -1.0480908155441284, -0.23698042333126068, -0.6017009615898132, -0.3947172164916992, 0.09484028816223145, 0.08238045871257782, 0.25800397992134094, -0.797649621963501, 0.48738038539886475, -0.35937798023223877, -0.18240056931972504, 0.9049192070960999, 0.04229292273521423, 0.7236863970756531, -0.00666011031717062, -0.0612131804227829, -0.03422091156244278, -0.23683303594589233, -0.014216816984117031, 0.5214653015136719, 0.5064894556999207, 0.7398561835289001, -0.21988418698310852, -0.31696152687072754, 0.4425787031650543, 0.22796019911766052, 0.13292650878429413, 0.22079342603683472, -0.01775866001844406, 0.10299509018659592, -0.37826353311538696, -0.014558607712388039, -0.34985485672950745, -0.020024262368679047, 0.2295973002910614, 0.17724943161010742, -0.6578882336616516, 0.1831914484500885, 0.10695032775402069, -0.5726817846298218, 0.07632438838481903, -0.5401376485824585, -0.4991394281387329, -0.06375356763601303, -0.2828971743583679, 0.30954182147979736, 0.2330213487148285, -0.29575836658477783, 0.2072521299123764, 0.09063126146793365, 0.06083551049232483, -0.4328203797340393, -0.3225678503513336, 0.01590060628950596, 0.1862105131149292, -0.06489671766757965, 0.545958399772644, 0.6355137228965759, 0.1195254996418953, -0.08115194737911224, -0.6245064735412598, -0.5939202308654785, 0.2693837583065033, -0.5702990889549255, -0.12043793499469757, -0.18346969783306122, 0.2827393412590027, -0.02558762952685356, -0.0013392227701842785, -0.03240339830517769, -0.9933453798294067, -0.39809513092041016, -0.2796074450016022, -0.7076218724250793, 0.5191382765769958, -0.15391774475574493, 0.7121787071228027, 0.06503479927778244, 0.13081538677215576, 0.44941774010658264, -0.31646254658699036, -0.14634017646312714, 0.8620923161506653, -0.40694597363471985, 1.3280384540557861, -0.1320689171552658, -0.06361108273267746, 1.0955873727798462, 0.5411935448646545, 0.006955383345484734, -0.4488929510116577, -0.24587461352348328, 0.5640254616737366, -0.2667745053768158, -0.5833919644355774, -0.21502220630645752, -0.1948544830083847, 0.21980366110801697, -0.10866862535476685, 0.06866384297609329, 0.08580332249403, -0.5093799829483032, 0.0539696142077446, 0.0503801591694355, -0.07624510675668716, -0.6538441181182861, 0.20636612176895142, -0.6336807012557983, -0.45802736282348633, 0.06843043118715286, 0.2522648274898529, -0.39966240525245667, 0.797752320766449, 1.0710736513137817, -0.2099865972995758, 0.9554187059402466, 0.5306392312049866, 0.51469486951828, 0.9728811383247375, 0.12309368699789047, 0.0991155356168747, -0.29056212306022644, 0.1855403184890747, 0.015724241733551025, 0.29242250323295593, 0.23169532418251038, 0.059574682265520096, -0.26228317618370056, -0.3183537721633911, -0.23707397282123566, 0.049675364047288895, 0.7770636081695557, -0.5117242336273193, -0.31462669372558594, 0.16234280169010162, -0.15584330260753632, -0.4107842445373535, 0.33209994435310364, -0.8399578332901001, 0.09567282348871231, 0.34294480085372925, 0.2392592430114746, 0.032728128135204315, -0.5507125854492188, 0.06847870349884033, 0.006427104119211435, -0.15974314510822296, -0.09899061918258667, 0.08387517184019089, -0.32467177510261536, -0.20616604387760162, -0.44775182008743286, -0.1508663147687912, 0.42614781856536865, 0.22823110222816467, -0.43058374524116516, -0.6044718027114868, -0.09203337877988815, 1.2224605083465576, 0.6360105276107788, 0.8636432886123657, -0.29985496401786804, -0.8836632370948792, -0.33647313714027405, -0.09157445281744003, -0.4057100713253021, -0.4926552176475525, 0.5745567679405212, -0.12684094905853271, -0.12473902851343155, 0.12781764566898346, -0.0545649453997612, 0.7398189902305603, -0.3389599621295929, -0.21653880178928375, 0.3316711485385895, -0.31488853693008423, -0.13430681824684143, -0.47949114441871643, -0.5306367874145508, -0.3064137399196625, 0.0838509202003479, -0.1416810005903244, -0.014204133301973343, 0.43050187826156616, -0.03112083673477173, -0.2739352583885193, 0.28997281193733215, 0.5333864092826843, -0.17518585920333862, 0.037090010941028595, 0.05602375790476799, -0.31385549902915955, -0.2836167514324188, -0.22665949165821075, 0.3061148226261139, -0.16289812326431274, -0.13228747248649597, -5.662166595458984, 0.024359606206417084, 0.2059035450220108, -0.42348697781562805, 0.18654245138168335, -0.2790898084640503, 0.964605450630188, 0.15202748775482178, 0.31172603368759155, 0.3797333538532257, 0.36035555601119995, 0.16961070895195007, 0.06502120196819305, -0.1520805060863495, -0.6157063841819763, -0.03466174378991127, -0.24613890051841736, 0.20256368815898895, 0.7557287216186523, -0.07065866887569427, 0.4035193622112274, -0.33329257369041443, -0.017743974924087524, 0.15174782276153564, -0.140341654419899, -0.21239450573921204, -0.959534227848053, -0.03523000702261925, -0.237420916557312, -0.42216846346855164, 0.02245069295167923, -0.43267622590065, 0.034826651215553284, -0.010551625862717628, 0.2042868733406067, -0.16747616231441498, 0.08438227325677872, -0.03980186954140663, -0.2757779359817505, -0.18933147192001343, 0.3296961486339569, -0.03914349153637886, -0.053948283195495605, -0.11078521609306335, 0.4376004934310913, -0.10608070343732834, -0.07148294895887375, 0.20312313735485077, -0.2907020151615143, 0.415772020816803, -0.24253515899181366, -0.40299269556999207, 0.4336269497871399, 0.344860702753067, 0.9067006707191467, 0.011375311762094498, -0.3946833908557892, -0.008902347646653652, -0.5412378311157227, 0.05066600441932678, -0.5346832275390625, -0.28062596917152405, -0.4325059950351715, -0.5899709463119507, 0.13975167274475098, 0.42764848470687866, -0.44631463289260864, -0.4501098394393921, 0.6515909433364868, -0.3713858127593994, -0.2838568389415741, 0.16806022822856903, 0.4236714243888855, -0.9221694469451904, 0.5645232200622559, -0.20413674414157867, 0.03628057241439819, 0.11712158471345901, -0.320732980966568, -0.26108720898628235, -0.5575022101402283, 0.0011084075085818768, -0.2296258509159088, -0.17332586646080017, 0.5430488586425781, -0.3806549608707428, -0.2568598985671997, 0.03013858199119568, 0.23126864433288574, 0.7731329798698425, 0.11587205529212952, -0.19675013422966003, 0.2303544282913208, 0.500162661075592, -0.07551775872707367, 0.3067961633205414, 0.15638615190982819, 0.6090901494026184, 0.3227664828300476, 0.15786057710647583, 0.3792495131492615, -0.31103184819221497, -0.29451239109039307, -0.5826540589332581, -0.11581093072891235, 0.34662219882011414, -0.6060482859611511, 0.24232961237430573, 0.5431525707244873, -0.6477254033088684, 0.13211773335933685, -0.04001617059111595, -0.5239855647087097, -0.2526468336582184, 0.6014993786811829, -0.34941452741622925, -0.3165735900402069, 0.10998605936765671, 0.5044930577278137, -0.612551748752594, 0.3714100420475006, 0.7745410799980164, -0.9961376190185547, 0.1381557434797287, 0.04975706338882446, -0.019157649949193, 0.06997250765562057, 0.22884026169776917, -0.32421064376831055, -0.12336236983537674, -0.19941042363643646, 0.3422906696796417, -0.06147317588329315, 0.18206000328063965, 0.3162195086479187, -0.6234287619590759, -0.4552405774593353, 0.5746036171913147, 0.08901461213827133, -0.01072657946497202, 0.22324584424495697, -0.15100477635860443, 0.20249544084072113, 0.017415115609765053, 0.39019080996513367, 0.09641668945550919, 0.0695277750492096, 0.2707795798778534, -0.5292152166366577, -0.2669472396373749, 0.47618305683135986, -0.6314660310745239, 0.05879431590437889, 0.10022503137588501, -0.38221821188926697, 0.36899006366729736, -0.06788992136716843, 0.4063800573348999, 0.6149982810020447, -0.36533111333847046, 0.22977036237716675, 0.042064934968948364, -0.5522473454475403, 0.011711201630532742, -0.2211001217365265, -0.391384482383728, 0.3227906823158264, -0.5262196063995361, -0.20481738448143005, 0.10934418439865112, -0.40159672498703003, -0.05486918240785599, 0.17748817801475525, -0.06736624240875244, 0.2339649349451065, -0.23388871550559998, -0.3498297333717346, 0.10508547723293304, 0.018616341054439545, 0.2780534327030182, 0.06755826622247696, -0.445381224155426, -0.06848426163196564, 0.4887191951274872, 0.29988357424736023, -0.02569517493247986, 0.28055617213249207, -0.45202144980430603, 0.18946941196918488, -0.7019953727722168, 0.20920825004577637, 0.14610852301120758, 0.14523932337760925, -0.086488738656044, 0.24214544892311096, 0.2537369430065155, 0.5039929747581482, 0.2748558521270752, 0.26266786456108093, -0.7608155608177185, -0.06067613139748573, 0.5874437093734741, 0.00563548831269145, 0.19212204217910767, 0.7071099281311035, -0.0028866096399724483, -0.47147244215011597, 0.004476945847272873, -0.2986440658569336, -0.2788310647010803, -0.04723365232348442, -0.3796321153640747, 0.2623763978481293, 0.17169435322284698, 0.17049221694469452, -0.47996050119400024, 0.6019452214241028, -0.49459266662597656, -0.1910816729068756, 0.1656874269247055, 0.2856786847114563, 0.4246298670768738, 0.15155671536922455, -0.053944751620292664, -0.5255751013755798, 0.13151830434799194, 0.3400132954120636, -0.644749641418457, 0.7269591689109802, -0.14319409430027008, -0.038172293454408646, -0.2290641814470291, -0.09725585579872131, -0.098054438829422, -0.20293448865413666, -0.951723575592041, 0.04438824951648712, 0.4750787317752838, 0.23815256357192993, 0.5347180366516113, 0.17724324762821198, 0.5489941239356995, -0.06046947464346886, -0.31235042214393616, -0.3047269582748413, 0.312791645526886, 0.4383317828178406, -0.7693538665771484, -0.07949471473693848, 0.36175376176834106, 0.16671453416347504, 0.1638176292181015, 0.13119308650493622, 0.6753169298171997, 1.2194911241531372, -0.1969660073518753, -0.21347366273403168, -0.5644333958625793, -0.29874759912490845, 0.09879060834646225, -0.41999176144599915, 0.06944996863603592, -0.10671855509281158, 0.142348513007164, 0.29581502079963684, 0.04340164735913277, -0.23497195541858673, -0.87873774766922, 0.28585004806518555, -0.11440099775791168, -0.34261566400527954, -0.1392001360654831, 0.2840692698955536, -0.16663961112499237, -0.28887397050857544, 0.46272918581962585, -0.08230628818273544, 0.1589599996805191, -0.09019633382558823, 0.06991097331047058, 0.3061087131500244, -0.6059635877609253, 0.7284404635429382, -0.6229655146598816, 0.28938496112823486, -0.5889848470687866, 0.026245681568980217, -0.886430025100708, 0.09509538114070892, -0.07980260252952576, -0.6210695505142212, 0.08951070159673691, -0.6674789190292358, -0.6767607927322388, 0.1486150324344635, 0.22850070893764496, 0.033745575696229935, 0.1453368216753006, -0.29991409182548523, 0.19316771626472473, -0.4082522988319397, 0.48359018564224243, 0.8341259956359863, -0.26142752170562744, -0.2790403664112091, 0.27289652824401855, -0.1430971771478653, 0.06624922901391983, -0.5092626214027405, 0.08204939216375351, -0.17578177154064178, 0.13572117686271667, 0.6923796534538269, -0.39938563108444214, -0.3984910547733307, 0.26359811425209045, -0.28372684121131897, 0.06543190777301788, -0.10085740685462952, 0.06108551472425461, 0.4035671651363373, 0.5985628962516785, 0.7605461478233337, -0.26675668358802795, -0.14920417964458466, 0.7098731398582458, 0.24346789717674255, -0.07774198800325394, 0.10070062428712845, 0.7103334069252014, 0.6153723001480103, -0.11684892326593399, 0.1793726235628128, 1.0576902627944946, 0.6578342914581299, 0.16611945629119873, -0.19401060044765472, -0.13264288008213043, -0.3564494252204895, -0.09779268503189087, 0.5464112758636475, 0.7334279417991638, -0.3264889419078827, -0.14547954499721527, 0.61040860414505, 0.252686083316803, 0.21474575996398926, -0.24278399348258972, 0.19151277840137482, 0.2553795874118805, 0.6161594986915588, -0.5106716752052307, -0.654146671295166, 0.447727769613266, -0.740638792514801, 0.08306041359901428, 0.426643043756485, -0.3465227484703064, -0.3176479935646057, 0.25755736231803894, -0.29219403862953186, -0.10388819128274918, 0.01218621339648962, 1.1255251169204712, 0.12978336215019226, -0.13710953295230865, 0.5843590497970581, 0.1297954022884369, 0.3884546756744385, -0.11762223392724991, 0.09683914482593536, 0.3866073787212372, 0.06808300316333771, 0.19323624670505524, 0.3272271454334259, -0.486245721578598, 0.20843958854675293, -0.3565298616886139, 0.09729032963514328, 0.5014154314994812, -0.34334596991539, 0.023850422352552414, -0.41841012239456177, -0.3801390826702118, -0.15364235639572144, -0.7014516592025757, -0.28904974460601807, -0.21449492871761322, -0.3237341642379761, 0.24269628524780273, 0.22125542163848877, -0.5898867249488831, 0.16700372099876404, -0.029436690732836723, 0.2550885081291199, 0.07102616876363754, 0.11901601403951645, 0.013131707906723022, 0.18512097001075745, 0.8402231335639954, 0.08052656054496765, 0.24609020352363586, 0.09693683683872223, 0.6297767758369446, -0.8964238166809082, 0.48803797364234924, -0.2595924735069275, -0.22630049288272858, -0.4854677617549896, -0.36262086033821106, 1.4550104141235352, 1.3120840787887573, -0.1346554160118103, 0.15537557005882263, 0.12407395988702774, 0.1785086840391159, 0.5040841102600098, -0.33462008833885193, -0.09065987914800644, -0.7008220553398132, 0.090601347386837, -0.9682490229606628, 0.8967116475105286, 0.217107892036438, -0.5562425851821899, -0.40312910079956055, 0.8633507490158081, -0.09493450075387955, -0.4403431713581085, 0.2576780319213867, -0.19494493305683136, 0.15329356491565704, -0.3074031174182892, 0.3741670846939087, -0.5773735046386719, 0.10137220472097397, -0.613278865814209, 0.018088385462760925, -0.24630990624427795, -0.0965171679854393, 0.17513799667358398, -0.16217435896396637, -0.4367600977420807, 0.23794227838516235, 0.19993983209133148, -0.029339158907532692, -0.21182481944561005, -0.8760582804679871, -0.5673721432685852, -0.057038191705942154, 0.554259717464447, 0.050632186233997345, -0.35167670249938965, -0.35469311475753784, 0.32785847783088684, -0.23144543170928955, 0.19459663331508636, -0.17941778898239136, 0.2346358597278595, 0.013640865683555603 ]
Correction for: Kurreeman FAS, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, et al. (2007) A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis. PLoS Med 4(9): e278. doi:10.1371/journal.pmed.0040278 In Table 1, the allele ratio in column eight (Allele Ratiosb: Cases, Controls) refers to allele A: allele B and not allele1:allele2 as described in footnote b, with Allele A being the Susceptibility Allele as denoted in column seven. The footnote should read: bNumber of alleles were compared in cases versus controls: allele A: allele B cases, allele A: allele B controls. Allele A refers to the susceptibility alleles as given in column seven.
[ -0.013228127732872963, 0.015942666679620743, -0.0015680582728236914, 0.014895045198500156, 0.013365030288696289, -0.005466085858643055, 0.006637800484895706, -0.0074495128355920315, -0.010882680304348469, 0.016482368111610413, -0.0023857345804572105, 0.009422671049833298, -0.01651904545724392, 0.02375100925564766, -0.025947630405426025, 0.015967102721333504, -0.02131422609090805, 0.004867433570325375, 0.015640387311577797, 0.010057949461042881, 0.020548339933156967, -0.024167079478502274, 0.008284501731395721, 0.0007345685735344887, -0.020778410136699677, -0.0184737928211689, -0.006294965744018555, -0.001798431621864438, -0.011703677475452423, 0.002312296535819769, 0.01681145653128624, 0.017199156805872917, 0.01874794438481331, 0.008707284927368164, 0.0023046869318932295, 0.006094519514590502, -0.007784335874021053, 0.009624000638723373, 0.032177940011024475, -0.004538988694548607, 0.0003958602901548147, -0.010573753155767918, 0.007402502931654453, -0.003472639247775078, -0.011565696448087692, 0.0027701263315975666, -0.0055946777574718, 0.008116221986711025, 0.007284549064934254, 0.005960454698652029, -0.0014135942328721285, 0.00010784738697111607, -0.017293324694037437, 0.005840955302119255, -0.004054491873830557, -0.013841976411640644, 0.01627650298178196, -0.013964461162686348, 0.010608358308672905, 0.044364314526319504, 0.0074386210180819035, 0.0005527427420020103, -0.000999972689896822, -0.003065073397010565, -0.0003720903769135475, -0.06708090007305145, -0.002361495979130268, 0.017090527340769768, -0.009218360297381878, -0.013316826894879341, -0.019642865285277367, 0.009636977687478065, -0.001325054094195366, -0.022779537364840508, -0.014716429635882378, -0.008693898096680641, -0.0020662506576627493, 0.02448374778032303, 0.018888333812355995, 0.022573042660951614, -0.0059493472799658775, -0.008591707795858383, 0.0038708364591002464, 0.015561665408313274, 0.004600650165230036, 0.023271990939974785, -0.007127811666578054, -0.012823418714106083, -0.018316447734832764, -0.018853357061743736, 0.010087373666465282, -0.0063837189227342606, -0.02313886396586895, -0.011691705323755741, -0.04446611553430557, 0.006281503476202488, -0.01531224325299263, -0.02282242849469185, 0.008909102529287338, -0.005290053319185972, -0.011883191764354706, 0.0034774094820022583, 0.012685210444033146, -0.005919562187045813, 0.007305050268769264, 0.006010564509779215, 0.0001580384559929371, 0.004614992067217827, 0.02115573361515999, 0.010937045328319073, -0.0022524085361510515, 0.022068753838539124, -0.013361126184463501, 0.00021916627883911133, 0.016232771798968315, 0.03763742744922638, -0.016899997368454933, 0.01894722878932953, 0.012863828800618649, -0.039514295756816864, 0.0015206134412437677, -0.018202725797891617, -0.004709085449576378, -0.0014341031201183796, 0.0019716243259608746, -0.011649200692772865, 0.010908589698374271, 0.008456213399767876, 0.01083627250045538, 0.006612532772123814, -0.006615655496716499, -0.006790250539779663, -0.005879879463464022, -0.014324058778584003, -0.014842242933809757, 0.002327599097043276, 0.002727916929870844, 0.005799881182610989, -0.023787211626768112, 0.009251387789845467, -0.006868096999824047, 0.006400042213499546, -0.004984126426279545, 0.002717431169003248, 0.0011711600236594677, 0.005966859869658947, -0.01504200417548418, 0.002763210330158472, -0.010394229553639889, -0.010513955727219582, 0.018998119980096817, 0.001966658979654312, -0.007290609646588564, -0.014832872897386551, -0.013011567294597626, 0.020149361342191696, -0.012659447267651558, -0.007219688966870308, -0.00872641522437334, 0.00669859629124403, 0.0027365409769117832, -0.001879185438156128, 0.015972139313817024, 0.008840312249958515, 0.007403750903904438, 0.0021459453273564577, -0.03535911440849304, -0.006730774417519569, 0.0008198783616535366, 0.003913035616278648, -0.0018447836628183722, -0.0026014959439635277, 0.010512959212064743, 0.004433986730873585, -0.022010166198015213, -0.01798398792743683, 0.0035763627383857965, 0.0054809171706438065, -0.016155457124114037, 0.06623870134353638, -0.001581280492246151, 0.005889219231903553, 0.009058916009962559, -0.012049955315887928, 0.019745036959648132, -0.009096763096749783, 0.00218794122338295, 0.0023715728893876076, -0.009467093273997307, -0.009774456731975079, 0.019746534526348114, -0.005644213408231735, -0.0195547454059124, 0.004363542888313532, -0.01260269433259964, 0.0014379607746377587, 0.012446428649127483, 0.005021810065954924, 0.02046985551714897, 0.0004837671294808388, 0.016971785575151443, -0.011420912109315395, 0.02250804379582405, -0.005080687813460827, 0.029308440163731575, 0.0001278968993574381, -0.0012276570778340101, 0.01667974516749382, -0.01482374221086502, -0.02252834290266037, 0.006425864528864622, -0.007320174016058445, 0.011697887443006039, -0.006660820916295052, 0.0014397110790014267, -0.00039143546018749475, -0.010555509477853775, 0.019392739981412888, -0.010141527280211449, -0.009931176900863647, -0.00897271279245615, -0.0010162086691707373, 0.001935709035024047, -0.021781526505947113, 0.025257684290409088, 0.011086152866482735, 0.004646487534046173, 0.011343256570398808, 0.00367438024841249, -0.013239249587059021, 0.005718103144317865, -0.01699463091790676, -0.015142275020480156, 0.015208697877824306, 0.033216528594493866, 0.02237580716609955, 0.012057401239871979, -0.00864557083696127, 0.006986196152865887, -0.0101255401968956, -0.0076788244768977165, -0.004349411465227604, 0.005772381089627743, -0.013277634978294373, 0.001750808209180832, 0.00717188511043787, 0.030031131580471992, -0.00006960798054933548, 0.004603323992341757, -0.01602792739868164, 0.0032741522882133722, -0.021431300789117813, -0.00511852977797389, 0.022602856159210205, 0.011983291245996952, 0.016974208876490593, 0.00792932603508234, -0.0029084603302180767, 0.0203105378895998, 0.012215560302138329, 0.002188863465562463, 0.006008792202919722, 0.00952192023396492, -0.025697272270917892, -0.013200649991631508, 0.012031583115458488, 0.005513271316885948, 0.014256658963859081, 0.03156629204750061, -0.0070965709164738655, 0.010680804029107094, -0.006342587061226368, 0.00030907412292435765, -0.08117125928401947, -0.007440246641635895, -0.01031023170799017, -0.051107361912727356, 0.004880782216787338, 0.03804606944322586, -0.033595599234104156, -0.013073746114969254, -0.008588532917201519, -0.01238370593637228, 0.006952356547117233, 0.02028103545308113, -0.012448808178305626, 0.01088071707636118, -0.01493661105632782, -0.008291160687804222, 0.006369662471115589, -0.003778891172260046, -0.01919126883149147, -0.03096073865890503, 0.00009369733743369579, 0.005729347933083773, 0.026025356724858284, -0.002615506062284112, -0.005936081521213055, 0.014741307124495506, -0.013684269972145557, 0.005364854820072651, 0.019656622782349586, 0.0061979349702596664, 0.003804055042564869, -0.003537033684551716, -0.011464087292551994, 0.010947490110993385, 0.02900567837059498, -0.008861714042723179, 0.0028615633491426706, -0.027126885950565338, -0.005252670031040907, -0.010662173852324486, 0.0007562665268778801, 0.021557435393333435, 0.0002910313196480274, 0.002313802717253566, 0.003963380120694637, 0.015706684440374374, -0.011888114735484123, 0.0018928861245512962, 0.018822574988007545, 0.0016229336615651846, -0.02423739992082119, 0.00027276453329250216, -0.014663618057966232, 0.015260616317391396, -0.0063112881034612656, -0.015628743916749954, 0.004523877054452896, -0.021960411220788956, -0.006784985773265362, -0.0177137590944767, 0.007943764328956604, -0.0043632593005895615, 0.022328879684209824, -0.0033533992245793343, -0.0033311930019408464, -0.003631934290751815, -0.0005994640523567796, -0.0019996280316263437, -0.02540564350783825, 0.017997929826378822, -0.013500619679689407, 0.005538895260542631, 0.006892340257763863, -0.002204196760430932, -0.001959165558218956, -0.00944450218230486, -0.018690824508666992, -0.010329063050448895, 0.01990603096783161, 0.02224341779947281, -0.010087789967656136, -0.009417975321412086, 0.011238126084208488, 0.017747709527611732, -0.02093101665377617, 0.007793126627802849, 0.011112898588180542, 0.02633531577885151, 0.009070556610822678, -0.009283737279474735, -0.02566405013203621, -0.007309022359549999, -0.0028207835275679827, 0.007017496973276138, 0.01581556536257267, -0.01107791531831026, -0.004304174333810806, -0.010826729238033295, -0.0033850246109068394, 0.004900025669485331, -0.003574259113520384, -0.011313047260046005, -0.0034634429030120373, -0.006443387363106012, 0.002038491889834404, 0.015741515904664993, -0.008131654001772404, -0.006391729228198528, -0.025861818343400955, -0.005313585512340069, 0.003036116948351264, -0.0006094742566347122, 0.00031578168272972107, -0.003420385532081127, 0.008471690118312836, -0.007118281442672014, -0.021181194111704826, 0.00856285635381937, 0.0732860416173935, -0.003897004993632436, 0.002346063032746315, 0.000321914441883564, -0.004476509056985378, 0.0055995783768594265, 0.02333744987845421, 0.00610884465277195, 0.02655745856463909, 0.0018709846772253513, 0.008184962905943394, -0.02535756304860115, 0.0037451274693012238, -0.010152271948754787, -0.030624685809016228, -0.010345231741666794, 0.021733377128839493, -0.02254580520093441, 0.00653440784662962, -0.007383173331618309, -0.01860426925122738, -0.0374622568488121, -0.011124297976493835, 0.00900658592581749, 0.020731288939714432, -0.02285427786409855, 0.013638293370604515, -0.013572843745350838, -0.0156130101531744, 0.00821266695857048, 0.014078443869948387, -0.01701362058520317, -0.011081413365900517, 0.005727438721805811, 0.02591737173497677, -0.000788407982327044, -0.014482114464044571, 0.01846351847052574, -0.0014460693346336484, -0.011291210539638996, 0.0011924561113119125, -0.01103876531124115, 0.00908210314810276, -0.007321770302951336, 0.008828351274132729, -0.013335423544049263, -0.01901409402489662, -0.010110639035701752, -0.011103929951786995, 0.014304901473224163, -0.012045510113239288, 0.00334485387429595, 0.010796594433486462, 0.01590300165116787, 0.00046749040484428406, -0.03117356076836586, 0.009962760843336582, -0.013440297916531563, 0.017281167209148407, -0.00024413783103227615, 0.003800735343247652, 0.01240526419132948, 0.007188125513494015, -0.018090518191456795, 0.01424398273229599, -0.006018046289682388, 0.008993098512291908, -0.01674620993435383, -0.024466726928949356, 0.01417635940015316, 0.019633086398243904, -0.004377587232738733, -0.0325220450758934, -0.006311115808784962, -0.006833462510257959, 0.002108687534928322, -0.006637320853769779, 0.005065069533884525, 0.02429177612066269, -0.009162737056612968, -0.02554319053888321, 0.0026600616984069347, -0.0027078050188720226, 0.017897091805934906, 0.006370107177644968, 0.0038424418307840824, -0.02744179591536522, -0.0746934562921524, -0.0014270143583416939, 0.011991588398814201, -0.005854291841387749, -0.0097196064889431, 0.006434485781937838, -0.019179921597242355, -0.021173622459173203, -0.002144026570022106, -0.007183359004557133, 0.0030796253122389317, 0.0006842466536909342, 0.0022847079671919346, -0.01215298566967249, 0.012030011974275112, 0.00008442066609859467, 0.013399677351117134, -0.007537205703556538, -0.016453757882118225, 0.026590310037136078, -0.005647482816129923, 0.0022197645157575607, -0.029844459146261215, -0.001726133981719613, 0.00008513056673109531, -0.08195929229259491, -0.02637762948870659, 0.015962008386850357, 0.005553896073251963, -0.00679633766412735, -0.012007534503936768, 0.006192450877279043, -0.01239945087581873, 0.02745620347559452, -0.011212708428502083, -0.028118938207626343, -0.033248525112867355, -0.01685342565178871, -0.007124375086277723, -0.0023681987076997757, 0.000035310309613123536, 0.019781501963734627, 0.014158375561237335, 0.0038643386214971542, -0.0011020726524293423, 0.006421830505132675, -0.015408972278237343, -0.005046145059168339, -0.006621349602937698, -0.007830644957721233, -0.02265320159494877, -0.013664722442626953, 0.011967106722295284, -0.006046743132174015, 0.0033223414793610573, -0.007158803753554821, -0.008096110075712204, -0.014159062877297401, -0.0017920612590387464, -0.01637660712003708, -0.018358930945396423, -0.008798213675618172, -0.020835209637880325, 0.005981410387903452, 0.011230737902224064, 0.00039539020508527756, -0.018572015687823296, 0.019174866378307343, -0.0024335826747119427, -0.0217828880995512, -0.011437777429819107, 0.008672038093209267, -0.01084049604833126, 0.013483698479831219, 0.0024996381253004074, 0.009431187994778156, -0.01624053157866001, -0.03769983723759651, 0.0004264451563358307, 0.015073993243277073, 0.002595923375338316, -0.0008376427576877177, -0.026732422411441803, 0.005500156432390213, -0.0056662894785404205, -0.0035510179586708546, 0.007202696055173874, 0.0049560824409127235, 0.07163246721029282, -0.005947973113507032, -0.012290419079363346, -0.015570361167192459, -0.0009581032209098339, 0.003859184682369232, -0.04023953899741173, -0.011064675636589527, -0.01797768473625183, -0.01952422596514225, -0.006790065672248602, -0.012978320941329002, 0.02919730544090271, 0.00885765440762043, 0.004956689663231373, -0.008914554491639137, -0.01477549783885479, 0.030829738825559616, 0.005535715259611607, -0.02077995240688324, 0.002832871861755848, -0.006019403226673603, -0.04340748488903046, -0.026253368705511093, 0.006202808581292629, -0.016175687313079834, -0.013473521918058395, -0.01695243827998638, 0.012253726832568645, 0.02006394788622856, -0.0024893051013350487, -0.011255950666964054, 0.006738103460520506, 0.0031638178043067455, -0.007619221694767475, -0.012982060201466084, 0.008076728321611881, 0.015779059380292892, 0.01044017355889082, -0.034795649349689484, -0.003829414024949074, -0.010766628198325634, -0.0011541011044755578, 0.00003450736403465271, -0.0048433709889650345, -0.006538676097989082, -0.004933977499604225, 0.015506410971283913, -0.0048393430188298225, 0.0006527119548991323, 0.026199011132121086, 0.010181155987083912, 0.018615292385220528, 0.0035002813674509525, -0.00010948744602501392, 0.035982660949230194, 0.017468499019742012, 0.012402290478348732, 0.013712998479604721, 0.024376263841986656, -0.0021690207067877054, -0.013042273931205273, 0.004829130135476589, -0.012585506774485111, -0.010345043614506721, -0.025577042251825333, 0.007093619089573622, -0.028338879346847534, -0.013687986880540848, 0.011867525056004524, -0.0015058766584843397, 0.009349284693598747, 0.005634577479213476, 0.0014556413516402245, 0.021557195112109184, 0.010737016797065735, 0.006057234480977058, 0.0030775696504861116, 0.016290469095110893, 0.0077989487908780575, 0.001241006888449192, -0.008379774168133736, -0.003642610041424632, -0.008168281987309456, -0.003172258846461773, -0.026952490210533142, -0.009097807109355927, 0.020386692136526108, 0.0010776713024824858, 0.009759144857525826, 0.003581923432648182, 0.0059060147032141685, 0.0011756783351302147, 0.018344145268201828, 0.00011070538312196732, 0.031302325427532196, 0.004939512349665165, 0.010378148406744003, -0.012710743583738804, 0.007859185338020325, 0.0012492737732827663, -0.011327914893627167, 0.01088679675012827, -0.008651102893054485, -0.0050994623452425, -0.0038431892171502113, -0.006421727128326893, -0.005370131693780422, -0.014130831696093082, 0.0012832535430788994, -0.0018792906776070595, 0.012639341875910759, 0.018876463174819946, -0.015603695064783096, 0.014295214787125587, 0.0307469479739666, -0.013624561950564384, -0.0044615063816308975, 0.005033177323639393, -0.015665020793676376, -0.01088070496916771, -0.022801952436566353, 0.0007944686803966761, 0.03620586171746254, 0.01042154897004366, -0.024498799815773964, -0.010280931368470192, -0.0040350789204239845, -0.005056790076196194, 0.007042786106467247, 0.014171691611409187, 0.02084132470190525, -0.016003020107746124, -0.01641545630991459, 0.01705365628004074, -0.019287236034870148, -0.022427016869187355, 0.007579304277896881, 0.009556462056934834, -0.004966365173459053, -0.0033014279324561357, -0.008979104459285736, 0.005478460341691971, 0.023397885262966156, 0.008113699033856392, 0.004784262739121914, 0.027658769860863686, 0.014251118525862694, 0.001677874242886901, 0.00768980011343956, 0.014892186038196087, 0.005799264647066593, -0.01813950017094612, -0.005523297004401684, -0.020085031166672707, 0.012261345982551575, 0.0050798822194337845, 0.0008481210097670555, -0.012559646740555763, -0.018810946494340897, 0.01737409085035324, 0.008001557551324368, -0.010189217515289783, 0.0127765703946352, 0.02909184619784355, 0.004584910348057747, -0.015371613204479218, -0.01464090496301651, 0.0066105956211686134, 0.0017852832097560167, 0.002490371000021696, -0.0018567494116723537, 0.0026442937087267637, 0.004228087607771158, -0.014262229204177856, 0.0022519160993397236, -0.00316671933978796, 0.004060490522533655, -0.030339408665895462, -0.016867727041244507, -0.0028437101282179356, -0.007042025215923786, 0.0075197829864919186, -0.010435528121888638, 0.023281043395400047, -0.005801906809210777, 0.0012940805172547698, 0.008596387691795826, -0.002054873388260603, 0.03323007747530937, -0.004764496348798275, -0.03547561168670654, 0.0009007632615976036, 0.005047867074608803, 0.012835659086704254, 0.001295279711484909, 0.013997411355376244, -0.018835822120308876, -0.007707800716161728, -0.006825536955147982, 0.01691402494907379, -0.00022277235984802246 ]
[ -0.3999998867511749, -0.12073127180337906, -0.006403595674782991, -0.19258004426956177, 0.1336359977722168, 0.7294979691505432, 0.40205439925193787, -0.5514122843742371, -0.4275028705596924, -0.28892484307289124, -0.14681683480739594, 0.4984014928340912, -0.36658549308776855, 0.23591825366020203, -0.33635184168815613, 0.8947004675865173, 0.6555806994438171, 0.0026259387377649546, -0.34409475326538086, -0.3816189765930176, 0.10784466564655304, -0.44973307847976685, 0.4225870966911316, 0.04452695697546005, -0.47841835021972656, -0.1485084891319275, 0.16262809932231903, -0.2245723009109497, -0.26564058661460876, 0.4078103005886078, -0.26070964336395264, 0.8866260647773743, -0.1167847216129303, -0.09175946563482285, -0.3954946994781494, 0.18406420946121216, 0.0110915033146739, 0.05906112119555473, 0.4748688340187073, -0.053493838757276535, 0.15430690348148346, -0.3978276550769806, -0.44346094131469727, 0.4402036666870117, -0.26908305287361145, 0.009831174276769161, -1.834966778755188, 0.21150118112564087, -0.1119656190276146, -0.4069029986858368, -0.04746689647436142, 0.06705260276794434, 0.5194598436355591, 0.13087990880012512, -0.06307809054851532, -0.025440804660320282, -1.0726450681686401, -0.31575316190719604, 0.07562890648841858, -0.1568097323179245, -0.07840877026319504, 0.12120222300291061, -0.10993438214063644, 0.4295015037059784, -0.3701803982257843, 0.530519962310791, 0.11521552503108978, 0.468563437461853, -0.38582679629325867, -0.12649716436862946, 0.16236604750156403, -0.2308328002691269, -0.15526682138442993, -0.1071903184056282, 0.22554974257946014, 0.35412198305130005, -0.29580530524253845, -0.3419080078601837, 0.3050261437892914, -0.4368521273136139, 0.4356011748313904, -0.3820329010486603, 0.264066219329834, -0.5848989486694336, 0.4014691412448883, -0.10378431528806686, 0.1394120305776596, 0.2239234447479248, -0.4018942713737488, -0.21436233818531036, 0.03985906019806862, -0.03530704975128174, 0.621371865272522, 0.8261964917182922, 0.03168647736310959, 0.06332015246152878, -0.05181730538606644, -0.0688634067773819, 0.5364458560943604, -0.2688174545764923, 0.04834400489926338, -0.1016809344291687, 0.06165746599435806, -0.41559842228889465, -0.4486684799194336, -0.49065080285072327, 0.13448458909988403, -0.45428481698036194, -0.6041911840438843, 0.2034359574317932, -0.7788997888565063, 0.40578800439834595, -0.2995449900627136, -0.06768203526735306, -0.7161617875099182, 0.3203541934490204, 0.1966983526945114, -0.20833224058151245, 0.22404570877552032, 0.277771919965744, -0.1386147141456604, 0.8541181087493896, 0.06014109030365944, 0.6425989270210266, 0.1280309110879898, 0.03693613409996033, 0.22895188629627228, 0.41438883543014526, -0.1705288589000702, 0.2964436411857605, 0.10997866839170456, 0.5842674970626831, -0.3342166543006897, 0.12866215407848358, 0.32716497778892517, -0.4210722744464874, 0.09652958065271378, 0.007524863816797733, 0.09940898418426514, 0.06964952498674393, -0.06458982825279236, 0.010439198464155197, -0.49356362223625183, -0.08578193932771683, 0.03953077644109726, -0.33449113368988037, 0.09045727550983429, 0.4913988709449768, 0.07994762063026428, 0.03290516883134842, 0.3342875838279724, -0.2845684289932251, -0.4562826454639435, -0.21467231214046478, -0.1815797984600067, 0.03612637147307396, -0.8323507905006409, -0.31401824951171875, -0.47204485535621643, 0.25694021582603455, 0.8026154637336731, 0.1956167072057724, -0.223162442445755, -0.08814333379268646, 0.982467770576477, -0.616814136505127, 0.1721336543560028, 0.15275268256664276, 0.20543351769447327, 0.33444035053253174, -0.5355772972106934, -0.17056697607040405, 0.23896411061286926, -0.5294508934020996, 0.06241514906287193, 0.5833604335784912, 0.029362939298152924, -0.007545161992311478, 0.035047393292188644, 0.18448980152606964, -0.6322479844093323, -0.266792356967926, 0.24959300458431244, -0.41131964325904846, 0.5249404907226562, -0.1170177012681961, 0.5072146654129028, 0.03207937255501747, 0.6022870540618896, 0.28918492794036865, -0.2670367360115051, 0.05104335770010948, 0.6810809969902039, -0.19837278127670288, 1.186346411705017, 0.06355412304401398, -0.09573185443878174, 1.415470838546753, 0.29850825667381287, 0.2248263955116272, -0.09169909358024597, -0.2621607780456543, 0.7146041393280029, 0.31370556354522705, -0.32152870297431946, 0.4574233293533325, -0.0438927486538887, -0.1933380365371704, -0.4827972948551178, 0.3542124032974243, 0.31152719259262085, -0.2569456100463867, -0.13357247412204742, -0.0245437603443861, 0.3860795497894287, -0.42168110609054565, 0.02632017619907856, -0.5524297952651978, -0.33941471576690674, -0.39185190200805664, 0.2329406440258026, -0.08644169569015503, 0.5377603769302368, 0.681681752204895, -0.11322612315416336, 0.9059932231903076, 0.6130548119544983, 0.22509260475635529, 1.0009838342666626, -0.11914657801389694, 0.2183486670255661, -0.04461536929011345, 0.23297347128391266, 0.10966579616069794, 0.2231554090976715, 0.3595818877220154, 0.3614157736301422, 0.05695171654224396, 0.1357317417860031, -0.26878172159194946, 0.0353301540017128, 0.42577606439590454, -0.423218309879303, 0.10949425399303436, -0.16706256568431854, -0.09392677992582321, -0.04086443781852722, 0.597210168838501, -0.8802763223648071, -0.0686100572347641, 0.44052910804748535, 0.03976975381374359, 0.21197915077209473, -0.4833056926727295, -0.33741918206214905, -0.0010260808048769832, -0.016356544569134712, -0.09495452046394348, -0.2578047215938568, -0.15277445316314697, -0.39184945821762085, 0.20017988979816437, 0.09038645774126053, -0.3178892135620117, -0.12907078862190247, -0.662216305732727, -0.9032210111618042, -0.33676624298095703, 0.871550440788269, -0.24632404744625092, 0.28244465589523315, 0.19818662106990814, -0.946783185005188, 0.09855341166257858, -0.49494779109954834, -0.6629015207290649, -0.527945339679718, 0.920303225517273, -1.0388643741607666, -0.3879395127296448, -0.2385680377483368, 0.5643935799598694, 0.9541445970535278, -0.43745526671409607, -0.1743125468492508, 0.10932627320289612, -0.08296489715576172, -0.2758679986000061, -0.36168646812438965, -0.41360899806022644, -0.33606207370758057, 0.7718437314033508, -0.2504339814186096, -0.0057455869391560555, 0.3630006015300751, 0.3776262700557709, -0.003447138238698244, 0.26627206802368164, 0.6636678576469421, 0.23706020414829254, 0.14205379784107208, 0.2566090524196625, -0.012466411106288433, -0.26711055636405945, -0.47851383686065674, -0.05373518913984299, -0.47470274567604065, 0.10147900134325027, -5.935083389282227, 0.03708140552043915, -0.3055483102798462, -0.25744232535362244, -0.0881742388010025, -0.27011799812316895, 1.4055131673812866, 0.34471583366394043, 0.23480156064033508, 0.06842723488807678, 0.2091352641582489, 0.20508138835430145, 0.054604921489953995, 0.2875104248523712, -0.32827091217041016, -0.048752255737781525, 0.27258360385894775, -0.3108871281147003, 0.04611857980489731, 0.4409460723400116, 0.28095462918281555, -0.12078477442264557, -0.18141163885593414, -0.11846132576465607, -0.29661649465560913, 0.598880410194397, -0.8660552501678467, 0.5114822387695312, -0.882544219493866, -0.7967751622200012, 0.13587549328804016, -0.3032190799713135, -0.27639225125312805, 0.018662896007299423, 0.06202584505081177, 0.33614733815193176, -0.1391044706106186, -0.01385364681482315, -0.2501482367515564, -0.3723084330558777, 0.06778061389923096, 0.30436161160469055, 0.2986487150192261, -0.24496644735336304, 0.014876188710331917, 0.27662473917007446, 0.09929318726062775, -0.01911499910056591, -0.17182178795337677, 0.6300036311149597, 0.18192186951637268, -0.374384343624115, 0.24878422915935516, 0.952514111995697, 0.35236120223999023, -0.3217813968658447, 0.01782264932990074, 0.31279680132865906, -0.3914843797683716, 0.15497423708438873, -0.012767236679792404, -0.1277298629283905, -0.04490705579519272, -0.8796025514602661, 0.11787248402833939, -0.21287962794303894, -0.672274649143219, -0.1787331998348236, 0.5646188855171204, -0.12806499004364014, -0.30703529715538025, 0.07610691338777542, 0.39126670360565186, -0.5571835041046143, 0.35236212611198425, -0.33010566234588623, 0.17261019349098206, -0.5548571348190308, -0.3406294286251068, -0.36039096117019653, 0.02975272759795189, -0.6295644044876099, -0.0828646793961525, 0.30838432908058167, 0.3547725975513458, -0.19882045686244965, -0.019407955929636955, -0.03363737091422081, -0.3371409475803375, 0.39482301473617554, 0.3012489676475525, -0.06679648160934448, 0.1222994402050972, 0.18816183507442474, -0.06698866188526154, 0.7426031827926636, 0.30263271927833557, 0.3732784390449524, 0.4350564479827881, 0.27403390407562256, 0.45035892724990845, -0.7570289373397827, 0.09871073067188263, -0.45849937200546265, 0.005387079436331987, 0.40492409467697144, -0.2691229581832886, -0.12070135027170181, 0.48673972487449646, -0.8135023713111877, 0.07177962362766266, 0.00762877706438303, -0.3648650348186493, -0.17981301248073578, 0.575201690196991, 0.0929504856467247, -0.049916189163923264, -0.41210871934890747, 0.6927894353866577, -0.240263894200325, 0.12245409190654755, 0.08227427303791046, -0.7602238655090332, 0.32977667450904846, -0.31767377257347107, -0.4698004424571991, -0.1864536851644516, 0.16150444746017456, -0.06961482763290405, 0.4531481862068176, 0.07985076308250427, 0.2569662034511566, -0.1118825152516365, -0.11030597984790802, 0.5238309502601624, -0.4784647524356842, 0.02539641037583351, 0.8149548172950745, -0.432205468416214, 0.10586243122816086, 0.329159677028656, -0.3239496350288391, 0.010312874801456928, 0.10592713207006454, 0.0741952434182167, -0.15321911871433258, 0.13567297160625458, -0.18846258521080017, -0.31843507289886475, 0.5719838738441467, 0.6068106889724731, -0.20081977546215057, 0.13865427672863007, 0.17122188210487366, -0.0094517907127738, 0.5176501870155334, 0.4616140127182007, 0.3170166611671448, 0.17616531252861023, -0.4593907296657562, -0.010656950995326042, 0.09621275216341019, -0.792972207069397, -0.3530115783214569, 0.2900148332118988, -0.18787881731987, 0.20206966996192932, -0.8662912249565125, -0.03868725150823593, 0.3570649027824402, -0.514245331287384, -0.25712040066719055, -0.40918225049972534, -0.1387919783592224, 0.3097397983074188, -0.025827903300523758, 0.009040470235049725, -0.47009360790252686, -0.47854071855545044, 0.3474549651145935, 0.1441633105278015, 0.048207856714725494, -0.04483349621295929, 0.735593318939209, 0.5719791650772095, -0.0068608494475483894, -0.25197914242744446, -0.2804940342903137, -0.07263119518756866, -0.4914678633213043, 0.49953246116638184, -0.20150399208068848, -0.006691971328109503, -0.06430535018444061, -0.1636584848165512, 0.1315886229276657, 0.21974670886993408, 0.5797116756439209, -0.047037266194820404, 0.07493073493242264, -0.07508927583694458, 0.6922237277030945, 0.28467506170272827, 0.5276042222976685, 0.8446176052093506, -0.26653894782066345, 0.03598663583397865, -0.13734900951385498, -0.7328336834907532, -0.2875954210758209, 0.19065441191196442, -0.7764004468917847, -0.19052743911743164, 0.013556797057390213, 0.12025143951177597, -0.20766569674015045, 0.14592477679252625, -0.4949032962322235, -0.3802407383918762, 0.3327217102050781, 0.12929977476596832, -0.3026755750179291, 0.21820467710494995, -0.24797633290290833, -0.2276647686958313, -0.43751969933509827, 0.17422574758529663, -0.5509971380233765, 0.3895116150379181, 0.1772615611553192, 0.061032526195049286, -0.04878569021821022, 0.2125212550163269, 0.41296136379241943, -0.4015299677848816, -0.4113658666610718, -0.7222165465354919, 0.3485301733016968, 0.3043692708015442, 0.035307951271533966, 0.10229548066854477, 0.465032696723938, -0.24595054984092712, 0.014488856308162212, -0.17537009716033936, -0.02312622219324112, 0.2584170401096344, -0.3668002486228943, -0.19322216510772705, 0.950168251991272, -0.0008990202331915498, 0.2362310290336609, 0.11811938136816025, 0.008670846931636333, 0.7212845087051392, 0.08875981718301773, 0.1851647049188614, -0.6739832162857056, 0.016717281192541122, 0.6671289801597595, -0.25029104948043823, 0.43630722165107727, 0.052771586924791336, -0.11070600897073746, -0.2286817580461502, 0.1399911791086197, -0.35237663984298706, -0.7530563473701477, 0.4601826071739197, -0.35681962966918945, -0.4786861836910248, -0.3697577118873596, 0.1814504861831665, 0.4870607554912567, -0.11845681816339493, 0.20692016184329987, 0.052085649222135544, 0.09976019710302353, 0.06713304668664932, 0.12028048187494278, -0.02809189446270466, -0.5242859721183777, 0.18413279950618744, -0.11772174388170242, 0.0053816731087863445, -0.3080917000770569, 0.05491921678185463, -0.08035506308078766, -0.3696027398109436, -0.24239042401313782, -0.510295569896698, 0.3131985068321228, -0.9069076776504517, -0.254085898399353, 0.23764599859714508, 0.3861016631126404, -0.036734312772750854, 0.7985963225364685, 0.024869436398148537, -0.3543523848056793, -0.6551526784896851, 0.10357064753770828, 0.45983627438545227, 0.12074554711580276, -0.397864431142807, 0.24933773279190063, 0.20829302072525024, 0.3831804394721985, -0.24335706233978271, 0.295471727848053, 0.363796204328537, 0.049646396189928055, 0.657117486000061, 0.4993865191936493, -0.05650707706809044, 0.0006317350780591369, -0.18899089097976685, 0.04173428192734718, 0.23002323508262634, -0.0336277037858963, 0.1260387897491455, 0.5566802620887756, 0.5670894980430603, -0.1543482542037964, -0.41029924154281616, 0.5629744529724121, 0.3068350851535797, 0.39788591861724854, -0.14313377439975739, 0.6649685502052307, 0.42578354477882385, 0.5930395722389221, 0.08298511058092117, 0.37582090497016907, 0.25556156039237976, -0.03361881524324417, 0.5014467835426331, -0.29418325424194336, 0.1784113049507141, -0.44554778933525085, 0.7245619893074036, 0.34531643986701965, 0.2101811021566391, -0.20105668902397156, 0.185531347990036, 0.2554345428943634, -0.11666920781135559, -0.07439202815294266, 0.12271840125322342, -0.13275562226772308, 0.037304800003767014, -0.4816291034221649, -0.48113587498664856, -0.127626433968544, -0.33127516508102417, 0.15132372081279755, 0.4331560730934143, -0.6667141914367676, -0.4391472041606903, 0.10189525783061981, -0.3312491476535797, -0.3352262079715729, -0.541259229183197, 0.3749840557575226, -0.4143734872341156, -0.14726243913173676, 0.4745381474494934, 0.23091833293437958, 0.23158150911331177, -0.3382101058959961, -0.1882774531841278, -0.23823586106300354, 0.19391712546348572, 0.022161314263939857, 0.3692541718482971, -0.5800414085388184, 0.37072521448135376, -0.024600766599178314, -0.03733045980334282, 0.692824125289917, 0.04499487206339836, -0.21028824150562286, -0.5767975449562073, -0.4410759508609772, -0.460906982421875, -0.5292119383811951, -0.2659245431423187, -0.1058984026312828, 0.1404249221086502, 0.15638606250286102, 0.316697359085083, -0.723054826259613, -0.3830629885196686, -0.18196500837802887, -0.13641522824764252, 0.11113866418600082, -0.0862477719783783, -0.025331512093544006, 0.18900565803050995, 0.24342119693756104, -0.0826004147529602, 0.3263613283634186, 0.16210955381393433, 0.543977677822113, -0.23401480913162231, 0.22530189156532288, 0.045089200139045715, 0.27692270278930664, -0.5571396350860596, -0.5543549060821533, 0.5806975364685059, 0.3896716833114624, -0.2511266767978668, 0.278456449508667, 0.1391492336988449, -0.888535737991333, 0.3832082450389862, -0.365492045879364, -0.4541407525539398, -0.44032496213912964, -0.3223067820072174, -0.25410884618759155, 0.6122774481773376, -0.40606018900871277, -0.5473443865776062, -0.2571319043636322, 0.3609251081943512, 0.44671425223350525, -0.07581532001495361, 0.5200446844100952, -0.6479918360710144, -0.22060619294643402, -0.4661117494106293, 0.10405964404344559, -0.4748585522174835, 0.011291642673313618, 0.016683429479599, 0.23788774013519287, 0.08232613652944565, 0.06613269448280334, -0.3123105466365814, -0.5201080441474915, -0.1546996533870697, 0.30481210350990295, 0.20189563930034637, 0.5080823302268982, -0.401504248380661, -0.2414156049489975, -0.33409473299980164, 0.04988600313663483, -0.29572686553001404, 0.12197253108024597, -0.5337713360786438, -0.27506494522094727, -0.1759112924337387, -0.686994194984436, -0.4370454251766205, -0.06132502108812332, 0.034715790301561356, 0.10662250965833664 ]
Although significant progress has occurred in the past 20 years regarding our understanding of Alzheimer disease pathogenesis, we have yet to identify disease-modifying therapeutics capable of substantially altering the clinical course of this prevalent neurodegenerative disease. In this short review, we discuss 2 approaches that are currently being tested clinically (γ-secretase inhibition and γ-secretase modulation) and emphasize the significant differences between these 2 therapeutic approaches. We also discuss certain genetic- and biomarker-based translational and clinical trial paradigms that may assist in developing a useful therapeutic agent.
[ 0.006193123292177916, 0.003922273404896259, -0.01032469142228365, 0.005858527030795813, 0.028407089412212372, 0.007823445834219456, 0.009312925860285759, -0.007257438264787197, -0.012833807617425919, 0.0022635275963693857, -0.005973762832581997, 0.005040609277784824, -0.005631371401250362, 0.011792373843491077, -0.01723410002887249, -0.007829483598470688, -0.014902526512742043, 0.015629233792424202, 0.00829427968710661, 0.01182609423995018, 0.0117529621347785, 0.005624893121421337, 0.010299420915544033, 0.0022915792651474476, 0.01606978476047516, 0.019487567245960236, -0.001291005639359355, -0.008937771432101727, -0.01256082858890295, -0.030851034447550774, 0.006360186729580164, -0.005053261294960976, 0.018607953563332558, 0.0077622439712285995, -0.011007564142346382, 0.008217615075409412, 0.0012583744246512651, 0.015466167591512203, 0.032046783715486526, -0.0048512802459299564, -0.007577178999781609, -0.00852266140282154, 0.0017274661222472787, -0.0027297474443912506, -0.005999641492962837, -0.0013481000205501914, -0.0009552351548336446, 0.009832886978983879, 0.004620297811925411, 0.009460927918553352, -0.000059215275541646406, -0.017011361196637154, -0.006591791287064552, 0.012230808846652508, -0.005768551025539637, -0.015279870480298996, 0.01806415058672428, -0.005624854471534491, 0.008648118004202843, 0.001393629820086062, -0.004463553428649902, -0.014057578518986702, 0.0005142501904629171, -0.013740133494138718, -0.018520552664995193, -0.06709280610084534, 0.009765742346644402, 0.02110823430120945, 0.0029138540849089622, -0.005449204705655575, -0.01335961278527975, 0.014000127092003822, 0.006695176009088755, 0.016053885221481323, -0.009166140109300613, -0.002188019221648574, 0.011219790205359459, 0.015462357550859451, 0.0002301603090018034, 0.016227010637521744, -0.03605244308710098, 0.0002902067790273577, 0.0019238315289840102, 0.013544948771595955, -0.022508705034852028, 0.008753818459808826, -0.009042446501553059, -0.0031005984637886286, 0.009035463444888592, -0.01898272894322872, 0.011483936570584774, -0.006790326442569494, -0.02068222500383854, -0.013543431647121906, -0.03159051388502121, 0.0056702070869505405, -0.00767437182366848, 0.0065944138914346695, 0.002041323808953166, 0.003869839943945408, -0.013275410048663616, 0.014719349332153797, 0.018485330045223236, 0.003445135895162821, -0.011605720035731792, 0.010237744078040123, 0.003205722663551569, 0.010298289358615875, 0.00485308188945055, 0.008047251962125301, -0.02119271643459797, 0.007878289557993412, -0.005620721261948347, 0.03557999059557915, 0.011035207659006119, 0.006318791303783655, 0.015195746906101704, 0.0025405350606888533, 0.013070622459053993, -0.013762187212705612, -0.008433232083916664, -0.000643301522359252, 0.013937022536993027, -0.02373569831252098, 0.007224495988339186, -0.0007229355396702886, 0.00026851746952161193, 0.0014311472186818719, 0.011868966743350029, 0.011624176986515522, -0.0071264030411839485, 0.0027395272627472878, 0.004373528994619846, -0.011887555941939354, 0.0003737531660590321, -0.004466896876692772, -0.009609722532331944, 0.016136808320879936, 0.0018873584922403097, -0.01046911533921957, 0.012849983759224415, 0.0063646272756159306, -0.003280088771134615, 0.0039823902770876884, 0.03240824118256569, -0.00028038074378855526, -0.006845114752650261, 0.0004819919413421303, -0.007285504136234522, -0.0011085758451372385, 0.03011888824403286, 0.014422687701880932, -0.0000731121253920719, -0.008198646828532219, -0.02342730015516281, 0.010755025781691074, -0.007728754077106714, -0.008099188096821308, -0.01716344803571701, -0.004451716784387827, -0.013458848930895329, -0.02636445127427578, 0.0034433589316904545, 0.008425270207226276, 0.008034905418753624, -0.009877970442175865, 0.0020315065048635006, -0.006807880941778421, -0.024024222046136856, 0.002518619876354933, -0.011687343008816242, 0.007031413726508617, 0.012994073331356049, 0.007835820317268372, -0.018044941127300262, 0.0012835238594561815, 0.026687879115343094, 0.0078088752925395966, -0.014141910709440708, 0.06710309535264969, -0.0077530317939817905, -0.011824541725218296, 0.017824416980147362, 0.003205812070518732, 0.01980867050588131, -0.004132898524403572, 0.00883761141449213, 0.00394801190122962, -0.013136330991983414, 0.014531341381371021, 0.004355016630142927, 0.018015949055552483, -0.004110245034098625, 0.003948756959289312, -0.01037165243178606, 0.0023747498635202646, -0.017122650519013405, 0.004438781179487705, 0.0074135796166956425, 0.003778902580961585, -0.00489391852170229, 0.011394988745450974, 0.02017497643828392, -0.020677445456385612, 0.03209952265024185, -0.00222404976375401, 0.03505953401327133, -0.0008701178012415767, -0.003389825811609626, -0.018108569085597992, 0.027524016797542572, -0.019340474158525467, 0.00475636450573802, -0.005109084770083427, -0.019382011145353317, -0.008479136973619461, -0.005383611191064119, 0.016233211383223534, 0.0188535675406456, -0.0117697948589921, 0.0017050380120053887, -0.008128968067467213, 0.02603165991604328, 0.0021548678632825613, 0.04610219597816467, 0.01631985232234001, -0.010685465298593044, 0.013345612213015556, 0.011665037833154202, -0.002469903789460659, -0.016772208735346794, -0.017115598544478416, -0.012300565838813782, 0.024957742542028427, 0.011707330122590065, 0.005876185372471809, 0.01331784576177597, -0.007465257775038481, 0.01668425463140011, -0.007626209408044815, -0.009424647316336632, -0.003397392574697733, 0.013313374482095242, 0.008458751253783703, 0.018306922167539597, 0.0025651378091424704, 0.0033354745246469975, 0.014719677157700062, -0.0077774981036782265, -0.014918595552444458, 0.0046424660831689835, -0.025565413758158684, 0.012486657127737999, -0.006724173203110695, 0.017718056216835976, -0.00900211837142706, 0.0012396520469337702, 0.0024441147688776255, 0.023138519376516342, -0.02669442631304264, -0.0008494633948430419, 0.005472313612699509, -0.008158143609762192, -0.006036185659468174, -0.006741533521562815, 0.008893375284969807, 0.01522842887789011, 0.011491364799439907, 0.027242818847298622, -0.0012506161583587527, 0.007373079191893339, -0.003562147729098797, 0.0008284196374006569, -0.08160707354545593, -0.013876102864742279, 0.003231855807825923, -0.004059117753058672, 0.009963996708393097, 0.011917907744646072, 0.008388333022594452, 0.0006425241590477526, -0.011671093292534351, -0.006143048405647278, 0.02776223048567772, 0.0017204034375026822, -0.004639447201043367, 0.0010644199792295694, 0.0005162702291272581, -0.003864387981593609, 0.0061545055359601974, -0.006581498309969902, -0.010430248454213142, -0.039121661335229874, 0.012905016541481018, 0.0015150175895541906, -0.004668155685067177, 0.0122861098498106, -0.01867772825062275, -0.004986324813216925, -0.02482363022863865, 0.003819161793217063, -0.008334474638104439, 0.010114203207194805, -0.0051906476728618145, -0.017204223200678825, 0.013550875708460808, -0.00776126142591238, -0.023832909762859344, -0.0010626165894791484, 0.008796450681984425, -0.008364629000425339, -0.010479345917701721, 0.0380723737180233, -0.0038563599810004234, 0.010760321281850338, 0.021604135632514954, -0.00474518770352006, 0.007081947755068541, 0.007332413457334042, 0.014732339419424534, 0.00809174869209528, 0.013813217170536518, -0.010654324665665627, 0.01945301704108715, 0.005342755001038313, -0.0020367854740470648, 0.016829947009682655, -0.016568155959248543, -0.010008067823946476, -0.008365396410226822, 0.0031262210104614496, -0.008570918813347816, -0.004305162932723761, 0.003501344472169876, -0.005912366323173046, 0.017104782164096832, -0.0045263576321303844, -0.00004131353125558235, 0.022241991013288498, 0.014888092875480652, -0.017396707087755203, -0.007287950254976749, 0.006182563956826925, -0.005141914822161198, -0.013094034045934677, -0.007341891061514616, 0.0021809875033795834, 0.011244882829487324, -0.013971857726573944, -0.010924052447080612, -0.003909380175173283, -0.0013537051854655147, -0.005399863235652447, -0.017251620069146156, 0.002467024140059948, -0.006247066427022219, 0.003210421185940504, -0.022638162598013878, -0.019371002912521362, 0.0053495015017688274, 0.019430523738265038, -0.0020260317251086235, -0.008578038774430752, -0.02539357915520668, 0.013120957650244236, 0.010451871901750565, 0.005424113944172859, 0.012030052952468395, -0.024523479864001274, -0.027815470471978188, 0.0036435748916119337, 0.01404225081205368, 0.009710779413580894, -0.0208329688757658, 0.0031927484087646008, -0.009866415522992611, -0.00969795510172844, -0.02094469964504242, 0.012168362736701965, 0.0016272675711661577, 0.011255333200097084, -0.0056734150275588036, -0.007939513772726059, -0.025754878297448158, 0.006027312949299812, -0.00667358236387372, 0.017941119149327278, 0.008089383132755756, 0.00002255163599329535, 0.003975007217377424, 0.008639270439743996, 0.07265292853116989, 0.025784337893128395, 0.007077476941049099, -0.015734486281871796, -0.0058710346929728985, -0.025009244680404663, -0.0060350061394274235, 0.0005565418978221714, -0.014306074008345604, -0.006557069253176451, 0.011261719278991222, -0.005903692916035652, 0.02553575299680233, -0.002913953270763159, -0.025633880868554115, -0.024230871349573135, 0.010580743663012981, 0.004038241691887379, 0.029823144897818565, 0.0005875646602362394, -0.005404600407928228, -0.04054008424282074, -0.01107019279152155, 0.009871737100183964, 0.013042575679719448, 0.00876808725297451, 0.018561774864792824, -0.010781008750200272, 0.006487034261226654, 0.004651925526559353, 0.009482638910412788, 0.007142628077417612, -0.00749310664832592, 0.014482693746685982, 0.028370380401611328, -0.004248012322932482, 0.017776543274521828, 0.011941814795136452, -0.009675513952970505, 0.0015342837432399392, 0.002657686360180378, -0.011195612139999866, 0.019736362621188164, 0.00925256498157978, -0.008729370310902596, 0.010428334586322308, 0.02300560101866722, -0.003488511312752962, -0.005560950376093388, 0.005282718688249588, -0.020788203924894333, 0.007105222437530756, 0.011568036861717701, 0.021247075870633125, 0.013267158530652523, -0.02713274024426937, 0.02156013250350952, -0.003253644099459052, -0.006902163382619619, -0.028377683833241463, -0.017302991822361946, 0.0021863323636353016, 0.020810483023524284, -0.016771230846643448, 0.017409754917025566, -0.010936933569610119, -0.0003056739515159279, -0.008303549140691757, 0.010562867857515812, -0.0127562852576375, 0.004791393410414457, 0.029475143179297447, -0.008582809939980507, 0.012742080725729465, -0.03922641649842262, -0.03988603875041008, 0.005638770759105682, -0.01310184970498085, 0.019328493624925613, -0.026720870286226273, 0.005646605975925922, 0.0028907868545502424, 0.007436508312821388, 0.0031200703233480453, -0.020301345735788345, 0.01054671872407198, -0.011653943918645382, -0.07487346976995468, -0.00015895292744971812, 0.008542494848370552, -0.006273611448705196, -0.014777866192162037, -0.010497194714844227, -0.02522728219628334, 0.012516793794929981, 0.021181540563702583, -0.0006388290203176439, 0.0022405569907277822, 0.007029482629150152, 0.011745152063667774, -0.006849879398941994, 0.011347471736371517, 0.03445548936724663, -0.01607823371887207, -0.00025655017816461623, -0.021502142772078514, 0.015232382342219353, 0.0022084577940404415, -0.009301500394940376, -0.020254502072930336, -0.0005491419578902423, 0.003948124125599861, -0.0813434049487114, 0.002805053722113371, -0.02361404523253441, -0.008574610576033592, -0.025824232026934624, 0.0038776404689997435, 0.0070894560776650906, -0.004302404820919037, -0.00011463765986263752, -0.016402317211031914, 0.01723012700676918, 0.01398339495062828, -0.012516229413449764, -0.010807041078805923, 0.0017952071502804756, -0.002745657926425338, 0.0013805743074044585, -0.0015974481357261539, 0.0022046498488634825, 0.006078914739191532, 0.0027085624169558287, 0.009478378109633923, -0.005856024567037821, 0.006465083919465542, -0.009592577815055847, -0.025010304525494576, -0.015378246083855629, 0.01302711945027113, -0.008958909660577774, -0.007778985891491175, 0.002794681116938591, 0.007374853827059269, -0.014787476509809494, -0.02695767767727375, -0.001179673825390637, -0.009629792533814907, -0.014057924970984459, 0.007058548275381327, -0.009882568381726742, -0.0059433565475046635, 0.001942391274496913, 0.0014427219284698367, -0.018792295828461647, 0.010098603554069996, -0.012353748083114624, 0.002163784811273217, 0.005253882613033056, -0.003945235628634691, 0.0009655964095145464, 0.012164612300693989, 0.009324525482952595, 0.00018272070155944675, 0.002263427712023258, 0.010950135998427868, 0.009371941909193993, -0.0020034683402627707, -0.00710870698094368, 0.00992975477129221, 0.01649155654013157, 0.0014245877973735332, -0.007561190985143185, -0.0008783841039985418, 0.01116325706243515, 0.07212980091571808, 0.018224790692329407, 0.007263933774083853, -0.004339136648923159, 0.00016543851234018803, -0.00023916563077364117, -0.020902270451188087, 0.001611946034245193, 0.010747743770480156, -0.02009366638958454, 0.013112734071910381, 0.005129082128405571, 0.0005654040724039078, 0.010344162583351135, -0.0004782477917615324, -0.01587071642279625, -0.012887285090982914, -0.005991152487695217, 0.0009098519221879542, 0.02866477333009243, -0.001438858569599688, 0.006167675368487835, -0.021037990227341652, -0.01877838931977749, 0.0034721943084150553, -0.003913430031388998, -0.013975223526358604, -0.02491244673728943, -0.002797067631036043, 0.018808647990226746, 0.0013837905135005713, -0.00006277289503486827, -0.005512862931936979, 0.0005113676306791604, 0.011529557406902313, 0.017409345135092735, -0.01330611016601324, 0.0027114497497677803, -0.0029317925218492746, -0.030931472778320312, -0.012703566811978817, -0.005951909814029932, -0.0017730972031131387, 0.0037163321394473314, 0.021169492974877357, -0.017587486654520035, 0.0006383090512827039, -0.013053622096776962, 0.0039194924756884575, 0.007925462909042835, 0.03405090048909187, -0.002509448677301407, 0.023395996540784836, 0.008668399415910244, 0.013851760886609554, 0.00733534200116992, -0.030482687056064606, 0.019910402595996857, -0.01566476561129093, -0.03833635523915291, 0.03016686998307705, -0.026006439700722694, -0.015027071349322796, -0.0153266042470932, -0.0034448455553501844, -0.011765608564019203, -0.0016909678233787417, -0.01718415692448616, 0.022631783038377762, 0.01609749160706997, -0.003186345100402832, 0.011123847216367722, 0.003330007428303361, 0.011950691230595112, 0.029594819992780685, 0.014789383858442307, 0.009618268348276615, 0.0032110384199768305, 0.008390744216740131, 0.007135794963687658, -0.011977901682257652, 0.01559822540730238, -0.0016588938888162374, 0.03236156702041626, -0.013261958956718445, 0.000726905302144587, -0.008248431608080864, 0.006985352374613285, 0.003507076995447278, 0.009255855344235897, 0.01952461153268814, 0.009450961835682392, -0.005622276104986668, 0.018057797104120255, 0.002793910214677453, 0.03310012444853783, 0.007545696571469307, 0.0022743616718798876, -0.0153431985527277, 0.010114200413227081, -0.016375556588172913, -0.0025273533537983894, -0.003004462691023946, 0.007070538587868214, 0.00046269388985820115, 0.003961590584367514, 0.04197654500603676, 0.002179516712203622, -0.005474617704749107, -0.007461609784513712, -0.012031818740069866, -0.010667980648577213, 0.026708194985985756, -0.005986487027257681, 0.006025255657732487, -0.020076045766472816, -0.0010835084831342101, -0.0020663535688072443, -0.003484445158392191, -0.011477133259177208, -0.014956405386328697, -0.022957129403948784, -0.010349364951252937, 0.01780138723552227, 0.014276699163019657, -0.005468022543936968, -0.011098138988018036, 0.016797862946987152, -0.008650753647089005, -0.018315525725483894, 0.01640678197145462, -0.0001697627449175343, -0.005046657752245665, -0.0043742540292441845, 0.01957589015364647, -0.016269810497760773, -0.006391787435859442, 0.03351163864135742, 0.002509450539946556, 0.0059099942445755005, 0.02328091859817505, 0.0040487973019480705, -0.006428818218410015, 0.02016996592283249, 0.00817742757499218, -0.005976187530905008, 0.02195863053202629, 0.037600453943014145, 0.011071864515542984, 0.0034851585514843464, -0.00035570308682508767, 0.011947978287935257, 0.010486525483429432, -0.0021557973232120275, -0.008010228164494038, 0.015390914864838123, -0.0016650734469294548, 0.009752289392054081, -0.019566794857382774, 0.0005525230662897229, 0.004526849836111069, 0.011211791075766087, 0.0197038222104311, -0.0015691084554418921, 0.008198609575629234, 0.02262144908308983, -0.008045721799135208, 0.016390360891819, 0.00560375489294529, -0.017809171229600906, 0.02763175033032894, -0.01113416999578476, -0.008810180239379406, -0.004158031195402145, -0.00820554792881012, -0.006416581571102142, -0.016649676486849785, 0.011325107887387276, -0.003486081724986434, 0.0075804064981639385, 0.021569861099123955, -0.024129999801516533, 0.012536987662315369, -0.006141544319689274, -0.017812935635447502, -0.003660119604319334, -0.0009912053355947137, 0.013759705238044262, 0.005519635044038296, -0.02190771885216236, -0.01350922230631113, -0.010285524651408195, 0.010247942060232162, 0.0013183437986299396, 0.0013049764093011618, -0.029526857659220695, 0.02177252247929573, 0.012456709519028664, -0.004863092675805092, 0.010974066331982613, 0.027569709345698357, -0.0032761069014668465 ]
[ -0.08263381570577621, 0.04518616944551468, 0.08271534740924835, -0.0020906056743115187, 0.23805959522724152, -0.04973004758358002, 0.30429360270500183, -0.38784071803092957, -0.10223604738712311, -0.7199772000312805, 0.29189616441726685, 0.3686266541481018, -0.18558025360107422, 0.4959157705307007, 0.40008261799812317, 0.7828385829925537, 0.40629151463508606, 0.10457464307546616, -0.06261754035949707, -0.3950059711933136, -0.5228025317192078, 0.1328989565372467, 0.7674090266227722, -0.2957344353199005, -0.3088459372520447, -0.18290743231773376, 0.44232505559921265, 0.01286520715802908, -0.15398330986499786, -0.04270824044942856, -0.2093934267759323, 0.6451132893562317, -0.4930361807346344, -0.4484310746192932, -0.08630228042602539, 0.4900270402431488, -0.043884508311748505, 0.09806621074676514, -0.12144514918327332, -0.31015485525131226, -0.36708712577819824, 0.08142656087875366, -0.42688897252082825, 0.5046167969703674, -0.18326514959335327, -0.6091287732124329, -1.6871401071548462, 0.17813804745674133, 0.013192945159971714, -0.3750479221343994, -0.039280641824007034, 0.14430132508277893, 0.26026758551597595, 0.2238195240497589, 0.339910089969635, 0.16281765699386597, -0.6479097008705139, -0.4622693657875061, 0.09892616420984268, -0.13871753215789795, 0.09709308296442032, 0.0050870501436293125, -0.3223000168800354, -0.37454888224601746, -0.28200629353523254, 0.24833738803863525, 0.34687820076942444, -0.27719688415527344, -0.5539191961288452, -0.17013438045978546, 0.29080265760421753, -0.40022486448287964, -0.40958884358406067, 0.20421680808067322, 0.1875474750995636, -0.4540921747684479, 0.2471470981836319, -0.4925348460674286, 0.18723136186599731, -0.09829330444335938, 0.2705455422401428, -0.004872808698564768, 0.17727358639240265, -0.10004217177629471, 0.46461039781570435, 0.18318472802639008, -0.024346468970179558, 0.4783947467803955, -0.7684666514396667, -0.42694443464279175, -0.29839643836021423, -0.20172765851020813, 0.25888189673423767, 0.42671701312065125, 0.5289434790611267, 0.3199940025806427, 0.2097591757774353, 0.16566163301467896, -0.11185331642627716, 0.5749030113220215, 0.20483723282814026, -0.10275329649448395, -0.12385190278291702, -0.2736968994140625, -0.0730847492814064, -0.7402113676071167, -0.23287631571292877, -0.8165048360824585, -0.6530824303627014, 0.2875475585460663, -0.7508512735366821, 0.4837634861469269, 0.13377097249031067, -0.23668159544467926, -0.4438355267047882, 0.18728570640087128, -0.03168155997991562, -0.31624090671539307, -0.3347928822040558, 0.5485758781433105, 0.2802572250366211, 1.7835081815719604, -0.2972199320793152, 0.2598401606082916, -0.0903383269906044, -0.06922442466020584, 0.3740118145942688, 0.19679801166057587, -0.34242159128189087, 0.20780780911445618, 0.08974289894104004, 0.27675604820251465, -0.6209420561790466, -0.059565238654613495, 0.02306395210325718, -0.36329635977745056, -0.017061203718185425, 0.08422104269266129, -0.008814196102321148, -0.11626043170690536, -0.35513806343078613, -0.7652375102043152, -0.320523738861084, 0.020620999857783318, 0.15305493772029877, 0.12897604703903198, 0.08773509413003922, 0.2765396535396576, -0.2726137340068817, 0.08871421962976456, -0.21423164010047913, 0.17377640306949615, -0.6988136768341064, 0.5670343637466431, -0.17850621044635773, 0.9181123971939087, -0.37025976181030273, -0.29925721883773804, -0.008433341048657894, 0.19624610245227814, 0.4509795904159546, -0.7786765694618225, -0.18835489451885223, 0.09888987988233566, 0.47386378049850464, -0.12891708314418793, 0.17158851027488708, 0.6315370202064514, 0.17386102676391602, -0.32681596279144287, -0.333085298538208, -0.03552345186471939, -0.026257310062646866, -1.1119714975357056, 0.28674817085266113, -0.026331370696425438, 0.5263766646385193, 0.272156298160553, 0.10377023369073868, 0.18496322631835938, -0.7902989387512207, -0.443063884973526, -0.20871984958648682, -0.6205214858055115, 0.4019198715686798, 0.16757643222808838, 0.6130724549293518, 0.17678633332252502, 0.5543002486228943, 0.06655847281217575, -0.22457729279994965, -0.1472904533147812, 0.7295991778373718, -0.6857550144195557, 1.3210753202438354, 0.03952571004629135, -0.1420457810163498, 1.3590450286865234, -0.04674362391233444, 0.1730031818151474, 0.0741366595029831, -0.20278175175189972, -0.16052410006523132, 0.12625356018543243, -0.5451974868774414, -0.2849016785621643, 0.20609772205352783, -0.15636293590068817, -0.24729257822036743, 0.31681331992149353, 0.8738763332366943, -0.6446241140365601, -0.06672057509422302, -0.22569172084331512, 0.19800670444965363, -0.20650099217891693, 0.16436731815338135, 0.38444021344184875, -0.7884410619735718, 0.039665259420871735, 0.580169677734375, -0.665890097618103, 0.41137608885765076, 1.0718835592269897, 0.28920117020606995, 1.103393793106079, 0.43061721324920654, -0.010855024680495262, 0.7159284949302673, -0.13671959936618805, 0.48762956261634827, -0.41080841422080994, 0.37522926926612854, -0.48632386326789856, -0.27255526185035706, 0.26539015769958496, -0.05975903570652008, -0.2614069879055023, -0.16615761816501617, -0.04234522953629494, -0.008300377987325191, 0.3925906717777252, -0.4150813817977905, 0.4027508795261383, 0.155411034822464, -0.36863139271736145, -0.32246437668800354, 0.3313078284263611, -0.6078037619590759, -0.3728807866573334, 0.29971301555633545, 0.3098045289516449, 0.6610665321350098, -0.7012866735458374, 0.2684819996356964, 0.4090312421321869, -0.44495412707328796, -0.40863117575645447, 0.10995852202177048, -0.3483333885669708, -0.044349540024995804, 0.28207868337631226, 0.14514821767807007, 0.07638867944478989, -0.03421889618039131, -0.5347176194190979, -0.31469812989234924, -0.5400500297546387, 0.20817074179649353, 0.4200766384601593, 0.7391722798347473, -0.1967356950044632, -0.7185444235801697, 0.14240732789039612, -0.12962721288204193, -0.4567626714706421, -0.07233142852783203, 0.7681958079338074, -0.9673386216163635, -0.19457298517227173, 0.030646411702036858, 0.7939441204071045, 0.7267417907714844, -0.1194630116224289, -0.9882503747940063, -0.011413474567234516, 0.06259113550186157, -0.48786529898643494, -0.5139719843864441, 0.290937215089798, -0.17570064961910248, 0.0010306192561984062, -0.5373317003250122, -0.13260941207408905, 0.015325569547712803, 0.33245009183883667, -0.37805190682411194, 0.1359592080116272, 0.49593356251716614, 0.06985031068325043, -0.3077625036239624, -0.009387783706188202, -0.27762874960899353, 0.09242488443851471, -0.11017381399869919, -0.27949872612953186, -0.7411405444145203, 0.5656033754348755, -5.668100833892822, -0.32550787925720215, -0.5757733583450317, 0.18190714716911316, -0.17077234387397766, -0.1646045297384262, 0.7334833741188049, -0.32361316680908203, 0.5228029489517212, -0.15532585978507996, 0.41785818338394165, 0.7011924982070923, 0.18984876573085785, 0.19859205186367035, -0.20803742110729218, 0.20219476521015167, 0.2471000850200653, -0.4085264503955841, 0.38321563601493835, 0.06339799612760544, 0.7643226385116577, -0.09214851260185242, -0.195232555270195, 0.7798056602478027, 0.060182735323905945, 0.10293639451265335, -1.0160365104675293, 0.4922510087490082, -0.07548358291387558, -0.33231624960899353, 0.2925824820995331, -0.24124544858932495, -0.2901339828968048, -0.2048889696598053, 0.4418744146823883, 0.7580804228782654, 0.10709545761346817, 0.1988660842180252, 0.019230211153626442, -0.5247193574905396, 0.6939365863800049, 0.09331654012203217, -0.5722952485084534, -0.06382853537797928, 0.08421510457992554, -0.13736149668693542, -0.06369560956954956, 0.6897330284118652, -0.13310816884040833, 0.7365109920501709, 0.23166480660438538, -0.03414274752140045, 0.7902591824531555, 0.7375897765159607, 0.3111760914325714, -0.45659199357032776, -0.06408479809761047, -0.1236717700958252, 0.024768486618995667, 0.397098183631897, -0.12441723793745041, -0.2124597132205963, -0.11505406349897385, -0.577536940574646, -0.04510436952114105, 0.1245436817407608, -0.49433204531669617, -0.8137702345848083, 0.15279583632946014, -0.19025984406471252, -0.6632471680641174, 0.32302913069725037, 0.5112419128417969, -0.5080133080482483, 0.617259681224823, -0.14624948799610138, 0.18696901202201843, -0.055282119661569595, -0.5258815884590149, -0.03844624385237694, -0.45545652508735657, -0.33982694149017334, -0.10595870018005371, -0.09533742070198059, 0.5972685217857361, -0.2767268717288971, -0.14186251163482666, 0.1455017477273941, -0.5266755819320679, -0.030910080298781395, 0.22372610867023468, -0.3201332688331604, 0.4087126553058624, 0.4771878123283386, 0.34873175621032715, 0.6567758321762085, 0.21814730763435364, 0.3814457952976227, 0.32222694158554077, -0.1269395798444748, 0.5666123032569885, 0.1577400118112564, -0.19847843050956726, -1.0003225803375244, 0.10307738184928894, 0.06905360519886017, -0.13504154980182648, -0.3173888921737671, 0.6027488112449646, -0.8192234635353088, -0.09376365691423416, 0.014714259654283524, -0.20357483625411987, -0.05146666243672371, 0.5552749037742615, -0.36869075894355774, -0.21452869474887848, 0.21998849511146545, 0.35537686944007874, -0.1309029906988144, 0.2684949040412903, 0.3509604334831238, -0.16960713267326355, 0.36267974972724915, 0.04966617375612259, -0.204545795917511, -0.03718425706028938, 0.7234944701194763, -0.5021806955337524, 0.1301880031824112, 0.669948399066925, 0.5383145809173584, -0.9160529971122742, 0.18647326529026031, 0.1988292783498764, -0.2772243916988373, -0.2622831463813782, 0.2689015865325928, 0.012567293830215931, -0.5540969967842102, 0.4768495261669159, -0.5225735306739807, -0.2520846724510193, -0.18770134449005127, -0.334617018699646, -0.30435314774513245, 0.17943857610225677, -0.04486579820513725, -0.545227587223053, 0.1405840516090393, 0.03420429676771164, -0.0554208979010582, -0.3776918053627014, -0.2674800455570221, -0.2366923689842224, 0.47194358706474304, 0.7362049221992493, -0.08459366112947464, 0.43589913845062256, -0.45152270793914795, 0.33459585905075073, 0.013883252628147602, -0.8235676288604736, 0.15432456135749817, -0.20003651082515717, 0.1561620980501175, -0.2639281451702118, -0.06645001471042633, 0.1449737846851349, 0.3971892297267914, -0.22109994292259216, -0.26446008682250977, -0.6316665410995483, -0.538348913192749, 0.4549247920513153, 0.002482092473655939, -0.20041711628437042, 0.031228920444846153, -0.35240525007247925, -0.3466314673423767, 0.4244491755962372, -1.2897495031356812, -0.4820233881473541, 0.08447584509849548, 0.5943270921707153, -0.15879058837890625, -0.0035958641674369574, -0.5079523921012878, -0.3506114184856415, -0.6616544723510742, 0.11555732041597366, 0.5244699120521545, 0.2252875417470932, -0.10127457976341248, 0.2201981097459793, -0.7869138717651367, 0.10709396004676819, 0.40337949991226196, 0.13695470988750458, -0.4497200548648834, 0.09446527808904648, 0.7793930172920227, -0.31797605752944946, 0.5276438593864441, 0.6742547154426575, -0.3143514394760132, -0.20996171236038208, -0.1887061446905136, 0.1984780728816986, 0.33175626397132874, -0.33901792764663696, -0.6871473789215088, 0.28805750608444214, 0.37172067165374756, -0.13018810749053955, 0.15511098504066467, 0.11077845096588135, -0.2096315622329712, -0.4722992181777954, 0.8054183721542358, 0.41116076707839966, -0.6778609156608582, -0.209416002035141, -0.06309153884649277, -0.6939184069633484, 0.04578189551830292, 0.5399854183197021, -0.6557696461677551, -0.5953658819198608, 0.09609311819076538, -0.25366973876953125, -0.04162312671542168, -0.10717356950044632, 0.2269829511642456, 0.04614876210689545, -0.5030990839004517, -0.26752400398254395, 0.5208490490913391, -0.40493839979171753, 0.4173639714717865, 0.15704184770584106, 0.5193787813186646, -0.45791053771972656, -0.4707369804382324, -0.5761936902999878, 0.23987771570682526, 0.17976884543895721, -0.5858621597290039, -0.5359326601028442, 0.18287627398967743, -0.02974984608590603, 0.0017141052521765232, -0.011953167617321014, 0.3444351851940155, 1.3076097965240479, -0.15781739354133606, -0.0171540305018425, -0.2509399950504303, -0.11193989217281342, 0.3615611791610718, -0.15854443609714508, 0.05144093930721283, -0.36812713742256165, -0.2827637791633606, 0.1676347702741623, -0.11235858500003815, -0.05740492418408394, -1.104853630065918, 0.48539960384368896, -0.20660214126110077, -0.3534592092037201, -0.21393746137619019, 0.7076480388641357, 0.7059330344200134, -0.17419002950191498, 0.25512561202049255, 0.0438443198800087, 0.021956080570816994, -0.5297154784202576, 0.20381079614162445, -0.010022052563726902, -0.3593301773071289, 0.0694633424282074, -0.4382045269012451, 0.2724507749080658, -0.8354620933532715, 0.22500072419643402, -0.4488525390625, 0.4081234037876129, -0.6796541213989258, -0.17701846361160278, 0.038483764976263046, -0.9480544328689575, -0.02601396106183529, -0.45534950494766235, 0.5446657538414001, 0.2495071142911911, 0.3121529519557953, -0.23507888615131378, -0.39265817403793335, 0.07121825218200684, 0.48688769340515137, 0.4870223104953766, -0.04278019443154335, 0.026876062154769897, 0.5891917943954468, 0.433815062046051, 0.15491938591003418, -0.1645803302526474, 0.2678907513618469, 0.3325316905975342, -0.11212704330682755, 0.6464464664459229, 0.8380262851715088, -0.14636042714118958, 0.49186861515045166, -0.11651302129030228, 0.13553965091705322, 0.2513008415699005, 0.22332270443439484, 0.47019660472869873, 0.23644819855690002, 0.48211124539375305, -0.47720593214035034, -0.40769222378730774, 0.6487206816673279, -0.06946825236082077, -0.015007982961833477, -0.05523988604545593, 0.2915661633014679, 0.5387443900108337, 0.6070389747619629, -0.012420055456459522, 0.6952157616615295, 0.4305993616580963, 0.44869464635849, 0.23895081877708435, -0.3420810401439667, -0.5525625944137573, -0.30319175124168396, 0.6115068197250366, 0.08884875476360321, -0.4569717049598694, -0.19924981892108917, 0.466098427772522, 0.4588105380535126, -0.0006207952974364161, 0.1965940147638321, -0.5391219854354858, -0.16799424588680267, 0.3987077474594116, 0.18421883881092072, -0.34147512912750244, 0.2548775374889374, -0.013855448924005032, -0.11813900619745255, 0.7340105772018433, -0.7210674285888672, -0.05811277776956558, 0.5287339687347412, 0.5569099187850952, 0.030038338154554367, -0.06961759924888611, 0.3610839545726776, -0.2235938459634781, -0.31308096647262573, 0.3677535951137543, 0.07038060575723648, -0.005337824579328299, 0.08001213520765305, -0.16363130509853363, -0.1348068118095398, -0.051930710673332214, 0.33368486166000366, 0.08722849935293198, -0.13362593948841095, 0.06506682932376862, -0.6152334809303284, 0.14391382038593292, 0.4473024606704712, -0.14619654417037964, 0.24455972015857697, -0.28168216347694397, -0.5809860825538635, -0.3135659396648407, -0.4162549078464508, -0.51563960313797, 0.21277855336666107, 0.26637017726898193, -0.31112217903137207, 0.06661535799503326, -0.4934985637664795, -0.42873629927635193, 0.1764143705368042, 0.4669780433177948, -0.25721409916877747, -0.032801706343889236, 0.5905116200447083, -0.20616517961025238, 0.34832847118377686, 0.22013075649738312, 0.3624809980392456, -0.08477455377578735, 0.8780066967010498, -0.34434565901756287, 0.2865046262741089, -0.529975414276123, -0.003888471517711878, -0.3689981698989868, 0.048599522560834885, 0.5311660766601562, 0.00016318644338753074, -0.3375672399997711, -0.29582470655441284, 0.233986496925354, 0.2863343060016632, 0.03825662285089493, -0.28567224740982056, -0.023459946736693382, -0.37792307138442993, 0.4815947711467743, -0.15457692742347717, 0.6545760631561279, -0.36568403244018555, -0.39156121015548706, -0.14688420295715332, 0.378805011510849, 0.17156149446964264, -0.00037573903682641685, 0.24177086353302002, 0.10881876200437546, -0.21776852011680603, -0.6183022856712341, 0.6098517775535583, -1.0043483972549438, -0.3538691997528076, 0.04754101485013962, 0.1332249790430069, 0.2773008644580841, -0.007896734401583672, -0.19576671719551086, -0.08634142577648163, 0.7478543519973755, 0.3859591484069824, 0.022153504192829132, -0.04671395942568779, -0.13226191699504852, -0.5333095788955688, -0.2906694710254669, 0.4874604344367981, -0.359977662563324, -0.044898487627506256, -0.2935071587562561, 0.31353652477264404, 0.1373932808637619, 0.34761717915534973, -0.3770679831504822, -0.8433085680007935, -0.024567270651459694, -0.3713800311088562 ]
Viruses that replicate in the cytoplasm cannot access the host nuclear capping machinery. These viruses have evolved viral methyltransferase(s) to methylate N-7 and 2'-O cap of their RNA; alternatively, they "snatch" host mRNA cap to form the 5' end of viral RNA. The function of 2'-O methylation of viral RNA cap is to mimic cellular mRNA and to evade host innate immune restriction. A cytoplasmic virus defective in 2'-O methylation is replicative, but its viral RNA lacks 2'-O methylation and is recognized and eliminated by the host immune response. Such a mutant virus could be rationally designed as a live attenuated vaccine. Here, we use Japanese encephalitis virus (JEV), an important mosquito-borne flavivirus, to prove this novel vaccine concept. We show that JEV methyltransferase is responsible for both N-7 and 2'-O cap methylations as well as evasion of host innate immune response. Recombinant virus completely defective in 2'-O methylation was stable in cell culture after being passaged for >30 days. The mutant virus was attenuated in mice, elicited robust humoral and cellular immune responses, and retained the engineered mutation in vivo. A single dose of immunization induced full protection against lethal challenge with JEV strains in mice. Mechanistically, the attenuation phenotype was attributed to the enhanced sensitivity of the mutant virus to the antiviral effects of interferon and IFIT proteins. Collectively, the results demonstrate the feasibility of using 2'-O methylation-defective virus as a vaccine approach; this vaccine approach should be applicable to other flaviviruses and nonflaviviruses that encode their own viral 2'-O methyltransferases.
[ 0.0007998223882168531, 0.020994290709495544, -0.0028226030990481377, 0.004273216240108013, -0.007995127700269222, -0.007480476051568985, 0.01171363890171051, 0.005464660003781319, -0.0171308983117342, -0.011384271085262299, -0.02286199852824211, 0.015657318755984306, -0.010519996285438538, 0.02407732978463173, -0.05257294699549675, 0.007295933552086353, -0.022250832989811897, -0.003885440994054079, 0.00816500186920166, 0.015653053298592567, -0.04631038382649422, -0.008608363568782806, 0.010887857526540756, 0.004778645001351833, 0.010099578648805618, 0.004437406547367573, -0.003957879729568958, -0.004079324658960104, -0.017233312129974365, 0.0015834737569093704, 0.008197382092475891, -0.004545013420283794, 0.014164958149194717, 0.009462843649089336, -0.00372763117775321, 0.02992349863052368, -0.007870045490562916, 0.03825192525982857, 0.05625512823462486, -0.005267299711704254, 0.009411297738552094, -0.012529954314231873, 0.006352866999804974, -0.01901383325457573, -0.010047206655144691, 0.019844243302941322, -0.0007722947630099952, 0.0304989293217659, -0.026475079357624054, -0.004028866067528725, -0.01567772589623928, -0.009785404428839684, -0.017657313495874405, 0.043253835290670395, -0.007409180514514446, 0.010124661028385162, 0.02044432796537876, 0.00685542356222868, -0.006642749533057213, -0.0055298819206655025, 0.02040461264550686, -0.020474649965763092, -0.005403127521276474, -0.002997925505042076, 0.0013670725747942924, -0.06613396853208542, 0.007656743284314871, -0.011850908398628235, 0.0029738913290202618, 0.040201641619205475, -0.01686130277812481, 0.004163490142673254, -0.0443229153752327, 0.030061865225434303, -0.011505579575896263, 0.007145088631659746, -0.026523243635892868, -0.015109035186469555, 0.0003671275917440653, 0.042841095477342606, 0.004786101169884205, -0.012686070054769516, -0.0005382564850151539, 0.009264275431632996, 0.017704807221889496, 0.004313542507588863, -0.018492441624403, 0.004022482316941023, 0.008404489606618881, -0.004480122122913599, 0.014939343556761742, -0.0019077679608017206, -0.04627806693315506, 0.012844589538872242, -0.03131426125764847, -0.020062945783138275, 0.023373454809188843, 0.007617016322910786, -0.025661010295152664, -0.016827430576086044, -0.0067951492965221405, 0.028526494279503822, 0.01788087747991085, 0.013977594673633575, -0.019942069426178932, 0.01012655533850193, 0.005442814901471138, -0.014753451570868492, 0.037888798862695694, 0.01653394103050232, -0.005583263002336025, -0.01715724542737007, -0.017299551516771317, 0.021906696259975433, 0.010839163325726986, -0.008036990649998188, -0.008797133341431618, -0.02565959468483925, 0.010475147515535355, -0.02148190140724182, -0.023688074201345444, -0.014050601981580257, 0.005884651094675064, -0.00983486883342266, 0.00840082298964262, 0.0132446913048625, 0.008116613142192364, 0.01267272513359785, 0.026243990287184715, 0.006929108873009682, -0.009430274367332458, 0.011491642333567142, -0.008429387584328651, -0.029539601877331734, -0.008028583601117134, 0.012464528903365135, 0.010008764453232288, -0.02746104821562767, -0.008123173378407955, -0.009576447308063507, -0.00972431804984808, 0.007236688397824764, 0.012699270620942116, 0.018951911479234695, 0.029160600155591965, 0.011462606489658356, -0.005926431622356176, 0.0050240131095051765, 0.020354725420475006, -0.012856378220021725, 0.029000651091337204, -0.009545720182359219, -0.011371806263923645, -0.005141535773873329, 0.004484697710722685, 0.010336566716432571, -0.001036025583744049, -0.021608754992485046, -0.011519890278577805, 0.011831503361463547, -0.0009066348429769278, -0.014663574285805225, -0.005170490127056837, 0.010921375826001167, 0.02158832550048828, -0.02611500397324562, 0.005949271842837334, -0.016549089923501015, 0.0069954898208379745, 0.010487305000424385, -0.0004279108252376318, 0.023695778101682663, 0.015269381925463676, 0.003810722380876541, -0.0054846154525876045, 0.00047571142204105854, 0.0024011675268411636, 0.00848337821662426, -0.011250413954257965, 0.06678813695907593, -0.008903075009584427, 0.041484422981739044, 0.031133301556110382, 0.02314085140824318, 0.024014923721551895, -0.015240445733070374, 0.02852334827184677, -0.00736728822812438, -0.01495231594890356, -0.006020876578986645, 0.0029712405521422625, -0.02150845341384411, -0.05565909668803215, 0.026334024965763092, -0.02642131969332695, 0.0032087089493870735, 0.015531984157860279, 0.015600115060806274, 0.032871127128601074, -0.0041690669022500515, -0.04550168290734291, -0.003625847166404128, 0.034032270312309265, -0.03360666707158089, -0.02392660826444626, -0.0048810141161084175, 0.011894941329956055, 0.035275187343358994, -0.007929098792374134, -0.010084210895001888, 0.053014855831861496, -0.0349225252866745, -0.001692532910965383, -0.017888646572828293, 0.0280015729367733, 0.02104979008436203, 0.04296288639307022, 0.03688059374690056, 0.004704639781266451, -0.013240903615951538, 0.0015405704034492373, -0.020858876407146454, 0.009975820779800415, 0.01559049729257822, 0.04104403033852577, -0.0037849179934710264, 0.01399136334657669, 0.014602608047425747, -0.029981110244989395, 0.02975299581885338, 0.004333318676799536, -0.041939277201890945, -0.013770941644906998, 0.02320616878569126, 0.01000371016561985, -0.051579639315605164, 0.013623022474348545, -0.0199754498898983, 0.004730903543531895, -0.01659863069653511, -0.005197126418352127, 0.010332930833101273, 0.0313517190515995, -0.029498089104890823, -0.00611319812014699, 0.027950335294008255, 0.002921588020399213, 0.015252562239766121, 0.03349264711141586, -0.0350843146443367, 0.01426745019853115, 0.012780915945768356, 0.020331289619207382, -0.0422130785882473, 0.004080161917954683, -0.00948850717395544, 0.0623282752931118, 0.0206378772854805, 0.02616719901561737, 0.004104942549020052, 0.010524903424084187, 0.009330684319138527, 0.011115329340100288, -0.015840299427509308, 0.026528451591730118, 0.022161275148391724, 0.010564591735601425, -0.011079950258135796, -0.02064482495188713, 0.023192377761006355, 0.00978083536028862, -0.0049856314435601234, -0.00830024667084217, -0.08114064484834671, -0.006092968862503767, 0.012415190227329731, 0.006515610031783581, 0.009694799780845642, -0.0248788483440876, -0.026970259845256805, -0.003907319623976946, -0.009159978479146957, 0.009790189564228058, 0.0010255728848278522, 0.041227687150239944, -0.011898508295416832, -0.03046579658985138, 0.021779729053378105, -0.0182925034314394, 0.011090321466326714, 0.0034997351467609406, -0.016003629192709923, -0.029777061194181442, 0.020096443593502045, 0.008238793350756168, 0.010506091639399529, 0.012504011392593384, -0.009678209200501442, 0.01879248209297657, 0.031167780980467796, -0.004447584971785545, -0.028632745146751404, 0.005255776457488537, -0.0418599471449852, 0.007431391626596451, 0.04073696210980415, 0.02139730006456375, 0.059486567974090576, 0.02641749568283558, -0.007673474028706551, -0.001822205726057291, -0.025061355903744698, 0.0163436196744442, -0.005387253127992153, 0.0014086789451539516, 0.01922718621790409, 0.025395866483449936, 0.012310581281781197, -0.004225046839565039, 0.008090252988040447, -0.005323247518390417, 0.01674024760723114, -0.015994222834706306, 0.019141510128974915, -0.003804891835898161, 0.01194135844707489, 0.023395957425236702, -0.0038012932054698467, 0.006606816314160824, -0.010135481134057045, -0.008378995582461357, -0.00946068949997425, -0.017584335058927536, 0.02313550002872944, -0.0277419351041317, 0.011870010755956173, 0.024603553116321564, -0.012951713055372238, 0.024156425148248672, 0.028151987120509148, 0.007179515436291695, -0.025704920291900635, 0.012187122367322445, -0.00718153640627861, 0.00685028824955225, 0.03428257256746292, -0.006270471960306168, 0.0011297473683953285, -0.00962802954018116, -0.0036025824956595898, -0.00023813341977074742, 0.0018555894494056702, -0.0370035283267498, -0.04447050765156746, -0.016943350434303284, -0.02185359224677086, -0.022165395319461823, -0.029308311641216278, -0.018089698627591133, 0.0039416104555130005, 0.02415742725133896, 0.013855190016329288, -0.019733183085918427, 0.01844336837530136, -0.006416564807295799, -0.0177219919860363, 0.01588352583348751, -0.03220956772565842, -0.03531800955533981, -0.005613999906927347, -0.018468275666236877, 0.03217142075300217, 0.009655769914388657, -0.014509711414575577, 0.0025477351155132055, 0.015544366091489792, -0.0038390732370316982, 0.007352902088314295, 0.014827355742454529, 0.0029987082816660404, -0.007400668226182461, -0.0001660357229411602, -0.00805841013789177, -0.007013825699687004, 0.010464167222380638, -0.010275529697537422, 0.004905120003968477, 0.005763294640928507, -0.005997134372591972, 0.0031905558425933123, -0.008798292838037014, 0.0708281472325325, -0.0182412751019001, 0.009772741235792637, -0.01178934145718813, 0.037131328135728836, -0.03743889927864075, 0.018596496433019638, 0.026105105876922607, -0.0378197580575943, 0.007585209794342518, 0.0141111696138978, 0.009900642558932304, 0.004219175782054663, -0.05311492085456848, -0.0019435806898400187, -0.000823277048766613, -0.020532118156552315, -0.007611230947077274, 0.05452311411499977, 0.04219500347971916, 0.014911007136106491, -0.00836773682385683, 0.001999570056796074, -0.030181940644979477, 0.010898357257246971, 0.026692571118474007, 0.05207710713148117, -0.016566960141062737, -0.01862359419465065, 0.010989747941493988, -0.008686183951795101, -0.0028593819588422775, -0.004258941393345594, 0.02112264186143875, 0.038739267736673355, 0.006314310245215893, -0.016225676983594894, 0.033924706280231476, -0.006586206145584583, -0.004515610169619322, -0.018516428768634796, -0.018959295004606247, -0.006173206493258476, 0.022827450186014175, 0.002719399519264698, -0.004276423715054989, 0.038219764828681946, -0.006569276098161936, 0.008585295639932156, 0.007149084936827421, -0.0015805498696863651, -0.012958351522684097, 0.01353625301271677, 0.03331582993268967, -0.002490982413291931, -0.014763705432415009, 0.03099413774907589, -0.01210370659828186, -0.006529852282255888, 0.013473795726895332, -0.0008205189369618893, 0.005886334925889969, 0.02038506045937538, -0.015591257251799107, 0.029351919889450073, -0.0181574746966362, -0.03593273460865021, 0.03321819752454758, -0.023734457790851593, -0.027673928067088127, 0.012943096458911896, -0.034955237060785294, 0.0008450690656900406, -0.060445576906204224, -0.046700239181518555, -0.004972423426806927, -0.02606278657913208, 0.01614387333393097, 0.015983087942004204, -0.0021596276201307774, 0.018802478909492493, -0.016358666121959686, -0.0293404683470726, 0.006343011744320393, 0.007647235877811909, -0.004002857953310013, -0.003997368738055229, -0.07363942265510559, -0.010016091167926788, -0.03666982799768448, -0.010249895974993706, 0.014675658196210861, -0.025228817015886307, -0.030613381415605545, -0.02091982215642929, -0.018799547106027603, -0.006662983447313309, -0.025622908025979996, 0.012469755485653877, 0.02717527374625206, -0.015939177945256233, 0.013677834533154964, -0.02603803016245365, -0.024410828948020935, 0.009107766672968864, -0.049237921833992004, 0.014654770493507385, -0.0088557293638587, 0.006598007865250111, 0.003047619480639696, 0.008004389703273773, -0.0010906246025115252, -0.07975222170352936, -0.008578473702073097, -0.0019154500914737582, 0.002522903960198164, -0.022834381088614464, -0.006638902705162764, -0.0048516495153307915, -0.0294857956469059, -0.005657413508743048, -0.01695244386792183, -0.0034695363137871027, 0.02174834907054901, 0.012205176055431366, 0.0032776189036667347, 0.0299336276948452, -0.011579304002225399, -0.014128029346466064, -0.000937887467443943, -0.018137913197278976, 0.03802212327718735, -0.008326487615704536, 0.026350941509008408, -0.018348222598433495, 0.0072989980690181255, -0.01567460596561432, -0.0019906493835151196, -0.02473459020256996, 0.008310070261359215, 0.013911222107708454, -0.00475776381790638, -0.022409694269299507, -0.0032975643407553434, -0.022926989942789078, -0.04968700557947159, 0.0034584011882543564, -0.0309920534491539, 0.005984037183225155, -0.02290475182235241, 0.015728170052170753, -0.023854520171880722, -0.01238990854471922, -0.012916176579892635, 0.027920980006456375, 0.005540474317967892, 0.021565306931734085, -0.004198205657303333, 0.009351691231131554, -0.011826719157397747, 0.02729930728673935, -0.0017142395954579115, 0.008669396862387657, -0.05107714235782623, 0.013660028576850891, -0.0001986650750041008, 0.0009817015379667282, 0.018288452178239822, -0.004094380885362625, 0.01856437511742115, 0.012023263610899448, 0.00043906504288315773, -0.020305147394537926, 0.00004643225111067295, 0.02242870256304741, 0.07145754992961884, -0.007940459065139294, 0.0256329532712698, -0.028413059189915657, 0.0025984258390963078, 0.010745150968432426, 0.014756287448108196, 0.00936914049088955, 0.016523003578186035, -0.034720517694950104, 0.017435207962989807, -0.01901249773800373, 0.0005908708553761244, 0.011205874383449554, 0.0005234973505139351, 0.02918696030974388, -0.04754827544093132, -0.00416532251983881, 0.0005858372896909714, 0.013144358992576599, 0.009771415963768959, -0.016969289630651474, -0.01048782654106617, 0.008207236416637897, 0.0396919772028923, 0.014776812866330147, -0.032084107398986816, 0.03181816264986992, -0.019294830039143562, 0.02458207681775093, 0.016201522201299667, 0.021481402218341827, 0.0056257592514157295, 0.014728810638189316, 0.01917121186852455, 0.02488519437611103, -0.00556515296921134, 0.016152989119291306, -0.020006587728857994, -0.004201018251478672, -0.012655816972255707, -0.016771618276834488, -0.008958046324551105, 0.008717494085431099, 0.010582544840872288, -0.013426882214844227, 0.03558594360947609, -0.007277019787579775, -0.0031544528901576996, 0.018471520394086838, 0.0335155688226223, -0.0010673212818801403, 0.017414426431059837, 0.007240349426865578, 0.025125499814748764, -0.007289774715900421, -0.02707139030098915, 0.010601416230201721, 0.006327812094241381, 0.02233903855085373, -0.006802964489907026, -0.013048481196165085, -0.011151107028126717, -0.017660360783338547, 0.02189664915204048, -0.022746223956346512, 0.006974334828555584, -0.019459346309304237, 0.018166517838835716, 0.018779587000608444, -0.0004616549704223871, -0.021360188722610474, 0.011217156425118446, -0.01646643690764904, 0.024985389783978462, 0.02525094337761402, 0.011051894165575504, -0.0070838164538145065, 0.022797076031565666, 0.014124032109975815, -0.007473981939256191, 0.015352101065218449, 0.009368125349283218, 0.025233807042241096, 0.021900413557887077, 0.02391964942216873, 0.008280275389552116, -0.003161960979923606, -0.0066855307668447495, 0.013636469841003418, 0.038889557123184204, 0.004246681462973356, 0.011379847303032875, -0.007560407742857933, 0.007790778297930956, 0.03552017733454704, 0.028989505022764206, 0.01283032912760973, 0.008340812288224697, 0.013380724936723709, 0.006594217382371426, -0.010364716872572899, -0.011043908074498177, 0.0031423065811395645, 0.006291672121733427, -0.012320354580879211, 0.010103928856551647, 0.016599109396338463, 0.011503152549266815, 0.023884370923042297, 0.007463198155164719, -0.008357331156730652, 0.007496445439755917, -0.0004718122072517872, -0.018996788188815117, 0.03323648124933243, -0.012896351516246796, 0.04359520226716995, 0.02108990028500557, -0.008739858865737915, -0.00601266510784626, 0.016075879335403442, -0.038422610610723495, 0.018762312829494476, -0.0039689005352556705, -0.005312351975589991, -0.011791424825787544, -0.0005679333116859198, -0.00465345848351717, -0.02074967697262764, 0.011711910367012024, -0.002968525979667902, 0.0017377552576363087, 0.019055187702178955, 0.016421811655163765, -0.00398076418787241, 0.026290643960237503, 0.0092786168679595, -0.023001328110694885, 0.007077153772115707, -0.014739210717380047, -0.014793433248996735, 0.005767329595983028, -0.005644234362989664, 0.008969826623797417, -0.000048145418986678123, -0.002285375725477934, 0.0006100572645664215, 0.0042637791484594345, -0.0019034342840313911, 0.02311304770410061, 0.010618843138217926, -0.04063120111823082, -0.010655401274561882, 0.0296794380992651, 0.007636836729943752, 0.005593258421868086, -0.0026891916058957577, 0.007835396565496922, -0.0028316511306911707, 0.002985552651807666, -0.00036421604454517365, 0.004484393168240786, 0.005454575642943382, -0.001112853642553091, 0.018877707421779633, -0.020708121359348297, 0.021379239857196808, -0.01263103075325489, -0.0015130636747926474, -0.0049835750833153725, -0.005528074223548174, -0.006272956728935242, -0.009516972117125988, -0.0074905650690197945, -0.01916956901550293, -0.019252313300967216, -0.0017335613956674933, -0.002474481239914894, -0.010898217558860779, 0.03007834404706955, -0.008236851543188095, -0.006136852316558361, -0.009041482582688332, -0.013065233826637268, 0.023377368226647377, -0.004390783607959747, 0.030977752059698105, 0.020398933440446854, -0.018486864864826202, -0.032040536403656006, 0.01831120252609253, 0.005117399618029594, 0.013234551064670086, 0.013176048174500465, -0.002412094734609127, 0.002115278271958232, -0.04123557358980179, 0.014596146531403065, 0.011049383319914341, 0.023947009816765785, 0.0006286951247602701 ]
[ 0.1931374967098236, 0.39040690660476685, 0.04837348312139511, 0.018817175179719925, 0.25724247097969055, -0.40468937158584595, 0.47813117504119873, 0.49154844880104065, -0.35366272926330566, -0.585708737373352, 0.4177647531032562, -0.14212149381637573, -0.7373648285865784, 0.627497136592865, -0.13555242121219635, 0.6774967908859253, 0.4068043529987335, 0.2941271960735321, -0.5817917585372925, -0.44846442341804504, -0.47955524921417236, 0.005176279693841934, 0.19249846041202545, -0.04462035745382309, -0.33432814478874207, -0.5049524903297424, 0.5048902630805969, -0.16469305753707886, 0.40834376215934753, -0.5618531107902527, -0.25992071628570557, 0.33419057726860046, 0.1236860454082489, 0.10859018564224243, -0.21122686564922333, -0.11519398540258408, -0.6427355408668518, 0.4991353154182434, 0.43525081872940063, -0.2236778438091278, -0.19283023476600647, -1.0669015645980835, -0.36579629778862, 0.05785244703292847, -0.12451136112213135, -0.9733499884605408, -0.9965307712554932, 0.9900782704353333, -0.35605305433273315, 0.1543133407831192, 0.22285404801368713, 0.35276180505752563, 0.034741900861263275, 0.01636485941708088, 0.47823432087898254, 0.31982284784317017, -0.5928733348846436, -0.13334017992019653, 0.6212039589881897, -0.5339394807815552, 0.3789847195148468, -0.15529343485832214, -0.35962173342704773, 0.20732372999191284, -0.01358918659389019, 0.8232078552246094, 0.27190881967544556, -0.31340429186820984, -0.828180193901062, -0.9694037437438965, -0.1877894252538681, -0.6881270408630371, -0.07422687113285065, 0.047400280833244324, 0.07486292719841003, -0.4587037265300751, -0.2159481942653656, -0.4263406991958618, 0.3409220278263092, -0.18990524113178253, -0.09075874835252762, 0.5145459175109863, -0.012026799842715263, 0.022437864914536476, 0.22981786727905273, 0.02476632036268711, -0.25744715332984924, 0.8272343277931213, -0.524420976638794, -0.2771977186203003, 0.01872309483587742, 0.43224984407424927, 0.3682774007320404, 0.3629329800605774, 0.0935545265674591, 0.2594103217124939, -0.41740989685058594, 0.4844551682472229, 0.47425052523612976, 0.5211447477340698, -0.40909871459007263, -0.18021240830421448, -0.09076385945081711, -0.45454517006874084, -0.26917633414268494, 0.1167786493897438, -0.007282953709363937, -0.6900040507316589, -0.6391709446907043, -0.12407423555850983, -0.4180191159248352, -0.30354827642440796, -0.6058602929115295, -0.07211259752511978, -0.40363869071006775, -0.026687638834118843, 0.3509591519832611, -0.7374825477600098, -0.39752262830734253, -0.3204497694969177, -0.5357427000999451, 1.4336626529693604, -0.1266200840473175, 0.41738077998161316, 0.021804306656122208, -0.27599474787712097, -0.08450111001729965, 0.1685512661933899, -0.37289518117904663, 0.24097885191440582, 0.389618843793869, 1.3103609085083008, -0.523619532585144, 0.6074187755584717, 0.4960981011390686, -0.25203120708465576, -0.20685620605945587, 0.6710001826286316, 0.16520990431308746, -0.6823422908782959, -0.7896791696548462, -0.28002262115478516, 0.009165158495306969, 0.47037002444267273, -0.13079863786697388, -0.3018554747104645, -0.38814985752105713, -0.22588767111301422, -0.3134787380695343, -0.3152337074279785, 0.1309572011232376, -0.45055922865867615, -0.7480930089950562, -0.018238665536046028, 0.28826916217803955, 0.21642650663852692, 0.14900536835193634, 0.3922301232814789, -0.10848396271467209, 0.41996675729751587, 0.28904926776885986, -0.13306142389774323, -0.6126068234443665, -0.5250609517097473, 0.4219506084918976, -0.09280943125486374, 0.47289347648620605, 0.3439772427082062, 0.34192320704460144, -0.07817517220973969, -0.2937973141670227, -0.1751592606306076, 0.22408023476600647, -0.3648848533630371, -0.023865655064582825, -0.5059961080551147, 0.13373784720897675, -0.25065091252326965, 0.329569935798645, 0.029994089156389236, -0.7120414972305298, 0.12718573212623596, -0.3574703633785248, -0.3816978335380554, 0.16931292414665222, 0.18196764588356018, -0.053768325597047806, 0.11367662996053696, -0.29337313771247864, -0.12605497241020203, -0.17948907613754272, 0.2165295034646988, 0.057700805366039276, -0.6420431733131409, 0.9648036360740662, -0.019553707912564278, -0.5065857172012329, 1.6523656845092773, 0.21796859800815582, -0.24095016717910767, -0.4860973656177521, 0.2813289165496826, 0.24132107198238373, -0.6440697312355042, -0.3278641700744629, 0.34653857350349426, 0.4874884784221649, -0.39558306336402893, 0.28189218044281006, 0.07993456721305847, 0.5118854641914368, -0.3621757924556732, -0.008860647678375244, -0.24375537037849426, 0.2876342535018921, 0.0018848298350349069, -0.5350005030632019, -0.20831555128097534, -0.5556332468986511, 0.1403810679912567, 0.4064028263092041, -1.0869206190109253, 0.4190145432949066, 1.0024962425231934, -0.10864914208650589, 1.1046459674835205, 0.28265848755836487, -0.005459035746753216, 0.8100406527519226, -0.2161940336227417, 0.7133806943893433, -0.6826685070991516, 0.566857635974884, -0.34536728262901306, -0.3830634355545044, 0.27782323956489563, 0.35874199867248535, 0.49372991919517517, 0.2779839038848877, 0.21877722442150116, 0.491871178150177, 0.7400974035263062, -1.009118676185608, -0.24951694905757904, -0.10627613961696625, -0.19190430641174316, -0.3592912554740906, -0.14757120609283447, -0.8871238231658936, 0.1339842975139618, 0.20490166544914246, 0.42324650287628174, 0.4016125500202179, -0.7507031559944153, 0.4601784348487854, 0.2628227472305298, -0.555587887763977, -0.09742152690887451, 0.31532490253448486, -0.0654870867729187, -0.5320183634757996, 0.10611265897750854, -0.28523027896881104, 0.5530610084533691, -0.18184590339660645, 0.11167903244495392, -0.34503600001335144, -0.15415319800376892, 0.7169219255447388, 0.9201853275299072, 0.7473533153533936, 0.09222913533449173, -1.0267210006713867, -0.1227390468120575, 0.28571903705596924, -0.36369994282722473, -0.047392964363098145, 0.49187707901000977, -0.2706927955150604, -0.3075896203517914, -0.29268938302993774, -0.05019170418381691, 0.8100191354751587, -0.5178373456001282, -0.03534546494483948, -0.21603956818580627, 0.03568645939230919, -0.056367240846157074, -0.8414673805236816, -0.7010173201560974, -0.5926816463470459, 0.6265187859535217, -0.3740220069885254, 0.502859354019165, 0.3234739601612091, 0.5344926118850708, -0.056486837565898895, 0.08301996439695358, 0.7433265447616577, -0.4078311324119568, 0.036749083548784256, -0.293760746717453, -0.25084733963012695, -0.2601564824581146, -0.09402871876955032, 0.13517959415912628, -0.002613734221085906, 0.03684628754854202, -5.556535720825195, -0.1259007751941681, -0.2522449195384979, 0.0728209987282753, -0.01768423616886139, -0.23670651018619537, 1.0193966627120972, 0.2123033106327057, 0.5204349756240845, -0.2664744555950165, 0.522218644618988, 0.2276374250650406, -0.008569291792809963, -0.16390353441238403, -0.08568022400140762, 0.06492183357477188, 0.4668298065662384, -0.29383835196495056, 0.43621474504470825, -0.2289440780878067, 0.2783350646495819, 0.40771278738975525, -0.2908814251422882, 0.10365103930234909, -0.46678751707077026, -0.005081663373857737, -0.6798913478851318, 0.1288890391588211, 0.014411802403628826, 0.1372876614332199, -0.20037412643432617, -0.7662515640258789, -0.13355480134487152, -0.4324173927307129, -0.1623893529176712, 0.22811968624591827, 0.01173034030944109, -0.43930932879447937, -0.41304636001586914, -0.043991029262542725, 0.36175432801246643, 0.22270721197128296, -0.06688494980335236, -0.20265403389930725, 0.31150758266448975, -0.48714908957481384, -0.033157993108034134, -0.022741273045539856, -0.2781519591808319, 1.0528115034103394, -0.19464123249053955, -0.4640350043773651, 0.6502191424369812, 0.8714877367019653, 0.5235261917114258, 0.02239581197500229, 0.09468282759189606, 0.17404277622699738, -0.2552461624145508, -0.3192552626132965, -0.26446881890296936, -0.23741300404071808, -0.17737969756126404, -0.42255979776382446, 0.3016602694988251, 0.059785544872283936, -0.6267164349555969, -0.3954857289791107, 1.186618447303772, -0.05330232158303261, -0.3524593710899353, -0.2564409673213959, 0.2721075713634491, -0.6283630132675171, 0.5549154877662659, -0.5750443935394287, -0.23465560376644135, -0.3598180413246155, -0.09838531166315079, -0.0321824736893177, -0.44789063930511475, -0.1501951664686203, -0.7351993918418884, -0.4648117423057556, 0.285053551197052, -0.6102167963981628, 0.22020910680294037, 0.1840556114912033, -0.48346981406211853, 0.2937522232532501, 0.3462913930416107, -0.008947150781750679, 0.2488497644662857, 0.39662811160087585, 0.33238527178764343, 0.4698196351528168, 0.26270362734794617, 0.6106588244438171, 0.518018901348114, -0.16441750526428223, 0.6787611246109009, -0.8094055652618408, -0.4577542841434479, -0.9902831315994263, -0.04500924423336983, -0.04869629070162773, -0.3024110794067383, 0.3233378529548645, 0.4216756820678711, -0.10783308744430542, 0.14824232459068298, 0.44665226340293884, -0.5776613354682922, -0.2696860134601593, 0.49675458669662476, -0.3404988944530487, 0.232696071267128, 0.8075168132781982, 0.7184171676635742, -0.6449138522148132, 0.42007091641426086, 0.6355963945388794, -0.640282154083252, 0.12834994494915009, -0.40429365634918213, -0.34897294640541077, 0.47696882486343384, 0.33080658316612244, -0.26128652691841125, -0.3642599582672119, 0.056498829275369644, 0.25641950964927673, -0.22028127312660217, -0.16659300029277802, 0.3011281490325928, 0.1631511002779007, -0.1962137669324875, 0.08941271156072617, -0.18810516595840454, -0.4744080901145935, -0.0007652072818018496, -0.3210899233818054, 0.22190818190574646, 0.21605953574180603, -0.2543691098690033, 0.32518813014030457, 0.09889941662549973, 0.4820689857006073, -0.0686483159661293, 0.01431140024214983, -0.05693107098340988, 0.6131760478019714, 0.23601779341697693, 0.2747817635536194, -0.3356837332248688, 0.17019033432006836, 0.6988413333892822, -0.0391484759747982, 0.7472901344299316, -0.5320941209793091, 0.01851755753159523, 0.4161827266216278, -0.4272392988204956, 0.37771904468536377, -0.4385213553905487, -0.017477640882134438, -0.06511048227548599, -0.5689047574996948, 0.10155463218688965, 0.2788774073123932, -0.7095295190811157, -0.010624910704791546, -0.25507524609565735, -0.3237035572528839, 0.21254874765872955, -0.08742047846317291, 0.2439919263124466, -0.09284703433513641, -0.1452222317457199, -0.18359844386577606, 0.08232752233743668, -0.5406957864761353, -0.27826154232025146, 0.6304445862770081, 0.27501416206359863, 0.3466844856739044, -0.008111369796097279, -0.25269871950149536, -0.6223342418670654, -0.38119256496429443, -0.03631342202425003, 0.334961473941803, 0.43240296840667725, -0.37376224994659424, 0.06192486733198166, 0.17954173684120178, -0.673524022102356, 1.184816598892212, -0.2045324444770813, -0.497218519449234, 0.021163547411561012, 0.5691480040550232, -0.27261286973953247, 0.4654892683029175, 0.30127838253974915, 0.34592336416244507, -0.0903264582157135, -0.5079384446144104, 0.2687464654445648, -0.4037931263446808, -0.18546631932258606, -0.3693811595439911, 0.04282010719180107, 0.6739941835403442, -0.11990153044462204, 0.4736699163913727, 0.016051603481173515, -0.0932040736079216, 0.19437600672245026, 0.49249160289764404, 0.37159058451652527, 0.12821607291698456, 0.10318341851234436, -0.1450897455215454, -0.19959038496017456, 0.8557382822036743, 0.05405867099761963, -0.7843807935714722, 0.30731868743896484, 0.3628447651863098, 0.5171887874603271, -0.8783572912216187, 0.14166946709156036, -0.16986873745918274, -0.449850857257843, -0.520579993724823, 0.21113231778144836, -0.09828495979309082, -0.32980960607528687, 0.5463662147521973, 0.9177353382110596, 0.10193029046058655, -0.7969746589660645, 0.006503726355731487, 0.14007674157619476, 0.46055495738983154, 0.7199754118919373, -0.4547232985496521, -0.769143283367157, 0.33504194021224976, 0.2503291070461273, 0.05551929399371147, -0.20998917520046234, 0.5387992858886719, 1.1803818941116333, 0.05995389074087143, -0.20827437937259674, -0.3564065098762512, 0.2123117297887802, -0.06970363110303879, 0.165364071726799, -0.15552639961242676, -0.5941062569618225, 0.06397243589162827, -0.0876152515411377, -0.15801437199115753, -0.1550435721874237, -0.06216125935316086, 0.28958210349082947, 0.5511267781257629, -0.12633492052555084, 0.14003556966781616, 0.6559888124465942, 0.6785269975662231, -0.5038434267044067, 0.5765895843505859, -0.25453612208366394, 0.19716913998126984, -0.12218884378671646, 0.2912372052669525, -0.5207164883613586, -0.48511484265327454, 0.3822864294052124, -0.4704262912273407, 0.00298790424130857, -0.08820109814405441, 0.062372852116823196, -0.5949074029922485, 0.12509439885616302, -0.3866308629512787, -0.4496825933456421, -0.2641300857067108, -0.5095184445381165, -0.36156323552131653, 0.37002167105674744, 0.5335180759429932, -0.10939610004425049, 0.19692865014076233, -0.20558013021945953, 0.0009077175636775792, -0.8024925589561462, 0.6180442571640015, 0.2882218062877655, -0.926851212978363, 0.023549804463982582, 0.07215028256177902, -0.001029772451147437, 0.7197331190109253, -0.5370441675186157, -0.0864269807934761, -0.20915812253952026, -0.29357007145881653, 0.24244697391986847, -0.38884878158569336, -0.34330958127975464, 0.42890870571136475, 0.024033453315496445, -0.588114321231842, 0.00002709656473598443, -0.1730094701051712, 0.32983651757240295, 0.3073985278606415, 0.04616618528962135, -0.33638861775398254, -0.3365163803100586, 0.14829997718334198, -0.05708412081003189, -0.6074272394180298, -0.4806082844734192, 0.29102927446365356, 0.8675262331962585, 0.16160500049591064, -0.3681272566318512, 0.5805491209030151, 0.1138731837272644, 0.3576500415802002, -0.08769438415765762, -0.4754270315170288, 0.019861571490764618, -0.22709695994853973, 0.5312910079956055, 0.3345624804496765, -0.1532566398382187, 0.17077605426311493, -0.023942863568663597, 0.1660546064376831, 0.017323080450296402, -0.09397878497838974, -0.0070847440510988235, 0.09556976705789566, 0.4609556496143341, -0.5658272504806519, -0.2628662884235382, 0.05778125301003456, -0.016019323840737343, -0.3242902159690857, 0.8244324326515198, -0.3353525996208191, -0.5590600371360779, 0.23536618053913116, -0.16713948547840118, 0.3802596926689148, 0.30897822976112366, 0.5108868479728699, -0.049536239355802536, 0.014588791877031326, 0.665737509727478, 0.014683594927191734, 0.1309068500995636, -0.42423465847969055, 0.5678337812423706, -0.19301319122314453, -0.2958921194076538, 0.45904114842414856, 0.1833225041627884, 0.09942374378442764, 0.12107536196708679, 0.14233729243278503, -0.028129274025559425, 0.22144080698490143, -0.45158207416534424, -0.20340660214424133, -0.30431315302848816, -0.45324546098709106, -0.2598402500152588, -0.30316299200057983, -0.1332249641418457, -0.21215374767780304, 0.17059539258480072, -0.011324750259518623, 0.47027286887168884, -1.0539528131484985, -0.08480119705200195, 0.21295468509197235, 0.2543049156665802, -0.09787911921739578, -0.17620664834976196, 0.41801342368125916, 0.10749716311693192, 0.33945655822753906, 0.024182258173823357, 0.14111150801181793, -0.11285118013620377, 0.61305832862854, -0.7102121114730835, 0.46476125717163086, -0.19783160090446472, -0.14106449484825134, -1.070151686668396, 0.20288945734500885, 1.226875901222229, 0.8497967720031738, -0.24049466848373413, 0.04534676671028137, 0.420452356338501, 0.3631618916988373, 0.281962513923645, -0.5322952270507812, 0.09859068691730499, -0.5635983943939209, -0.19063647091388702, -0.3581976294517517, 1.0482617616653442, 0.35706332325935364, -0.10628476738929749, 0.08349786698818207, 0.2963864803314209, 0.30419260263442993, -0.5472314357757568, -0.2049795687198639, -0.12625926733016968, 0.3451860845088959, -0.1913319081068039, 0.5800567865371704, -0.4210349917411804, -0.07552504539489746, -0.16507236659526825, 0.38145431876182556, 0.06073818728327751, 0.04355502501130104, 0.6469919085502625, -0.12735986709594727, 0.09459473192691803, -0.13774654269218445, -0.1605144739151001, -0.5035426616668701, -0.053934141993522644, -0.24394865334033966, -0.4158068597316742, 0.3690601587295532, -0.1241585984826088, 0.006671244744211435, 0.0483044795691967, 0.25689709186553955, -0.08835459500551224, 0.21580418944358826, -0.044566504657268524, -0.016625043004751205, -0.3207959532737732, 0.5458823442459106 ]
OBJECTIVE To determine whether individual fruits are differentially associated with risk of type 2 diabetes. DESIGN Prospective longitudinal cohort study. SETTING Health professionals in the United States. PARTICIPANTS 66,105 women from the Nurses' Health Study (1984-2008), 85,104 women from the Nurses' Health Study II (1991-2009), and 36,173 men from the Health Professionals Follow-up Study (1986-2008) who were free of major chronic diseases at baseline in these studies. MAIN OUTCOME MEASURE Incident cases of type 2 diabetes, identified through self report and confirmed by supplementary questionnaires. RESULTS During 3,464,641 person years of follow-up, 12,198 participants developed type 2 diabetes. After adjustment for personal, lifestyle, and dietary risk factors of diabetes, the pooled hazard ratio of type 2 diabetes for every three servings/week of total whole fruit consumption was 0.98 (95% confidence interval 0.97 [corrected] to 0.99). With mutual adjustment of individual fruits, the pooled hazard ratios of type 2 diabetes for every three servings/week were 0.74 (0.66 to 0.83) for blueberries, 0.88 (0.83 to 0.93) for grapes and raisins, 0.89 (0.79 to 1.01) for prunes, 0.93 (0.90 to 0.96) for apples and pears, 0.95 (0.91 to 0.98) for bananas, 0.95 (0.91 to 0.99) for grapefruit, 0.97 (0.92 to 1.02) for peaches, plums, and apricots, 0.99 (0.95 to 1.03) for oranges, 1.03 (0.96 to 1.10) for strawberries, and 1.10 (1.02 to 1.18) for cantaloupe. The pooled hazard ratio for the same increment in fruit juice consumption was 1.08 (1.05 to 1.11). The associations with risk of type 2 diabetes differed significantly among individual fruits (P<0.001 in all cohorts). CONCLUSION Our findings suggest the presence of heterogeneity in the associations between individual fruit consumption and risk of type 2 diabetes. Greater consumption of specific whole fruits, particularly blueberries, grapes, and apples, is significantly associated with a lower risk of type 2 diabetes, whereas greater consumption of fruit juice is associated with a higher risk.
[ 0.005713437683880329, 0.013493570499122143, -0.017682388424873352, 0.01565610244870186, -0.005297898780554533, -0.004872855730354786, 0.006834110710769892, 0.018004070967435837, -0.01233650278300047, 0.0048354621976614, -0.004656215198338032, 0.008402573876082897, 0.0053364890627563, 0.00936686247587204, 0.004551399499177933, -0.009955402463674545, -0.01709572598338127, -0.011461258865892887, 0.000894901342689991, 0.009723328985273838, 0.0200338251888752, 0.013431809842586517, 0.008024939335882664, 0.026548855006694794, -0.018919408321380615, 0.012842044234275818, 0.023498566821217537, 0.0012939609587192535, -0.004748336039483547, 0.013731300830841064, 0.00799981877207756, -0.0034379255957901478, -0.013204739429056644, 0.006373997777700424, 0.0006303824484348297, 0.012325910851359367, 0.0007754235994070768, 0.006234664469957352, -0.0013216659426689148, -0.003972521983087063, -0.0027803571429103613, -0.009325655177235603, 0.004336852114647627, -0.014964588917791843, -0.006750762462615967, 0.014176059514284134, -0.005182681605219841, -0.01795603334903717, 0.007351967506110668, 0.009381502866744995, -0.0015623087529093027, 0.02514735609292984, -0.016651157289743423, -0.007256187032908201, -0.004494974389672279, 0.013866364024579525, 0.01713421940803528, 0.012229623273015022, -0.0017813942395150661, 0.01776306703686714, -0.010641613975167274, -0.0033746708650141954, 0.0013527418486773968, -0.014493526890873909, -0.01574580743908882, -0.0677068680524826, 0.018172528594732285, 0.005107882432639599, 0.0010322565212845802, -0.003932686522603035, 0.00022447342053055763, 0.0132950060069561, 0.011600179597735405, 0.015101831406354904, -0.014025077223777771, 0.004158240742981434, 0.016283085569739342, 0.004290397744625807, 0.004153403453528881, -0.004505826160311699, -0.01208125427365303, 0.013540230691432953, 0.001987749245017767, 0.01751108653843403, 0.0074439747259020805, 0.00018690619617700577, -0.011136069893836975, -0.004846459254622459, -0.008657759986817837, 0.001888182247057557, 0.017902102321386337, -0.0059423912316560745, -0.007385734934359789, 0.0020390846766531467, 0.016806423664093018, -0.006120063830167055, -0.026614952832460403, 0.009544409811496735, 0.0012680785730481148, -0.002370033413171768, -0.0022451765835285187, 0.0010960485087707639, 0.016810480505228043, 0.017304781824350357, -0.0038844828959554434, 0.008558066561818123, 0.0011379148345440626, 0.006997749209403992, -0.0037985192611813545, 0.0011746441014111042, 0.0030918954871594906, -0.000016800593584775925, 0.03175605833530426, 0.0022010221146047115, 0.008473997935652733, -0.007839038968086243, 0.011141459457576275, -0.0013834359124302864, 0.0023025711998343468, -0.007329567335546017, 0.012817667797207832, -0.0032323768828064203, -0.01154288835823536, 0.01592288725078106, 0.0044358959421515465, -0.010990208014845848, -0.00006589118856936693, 0.01200067438185215, 0.018427954986691475, -0.003762804204598069, -0.0027669407427310944, -0.010988634079694748, -0.01855611987411976, 0.007295229472219944, -0.0026889147702604532, 0.0003137922612950206, 0.0021966523490846157, 0.0045032440684735775, -0.008433555252850056, -0.011565114371478558, -0.015709521248936653, 0.008116110228002071, 0.00232689012773335, 0.0034699419047683477, 0.021386662498116493, 0.01372623536735773, 0.005765833891928196, 0.0024717897176742554, 0.003979150205850601, -0.01326028909534216, -0.007489116862416267, -0.010906188748776913, 0.009803548455238342, -0.01364484615623951, 0.022937430068850517, 0.0023147817701101303, -0.003142108442261815, 0.004269914235919714, 0.0033488136250525713, 0.006635017693042755, -0.021732840687036514, 0.016356412321329117, 0.002748897997662425, 0.007177714258432388, -0.0020454602781683207, 0.014474056661128998, -0.008985741063952446, -0.0017896757926791906, -0.02070458047091961, 0.0012594611616805196, -0.0020523634739220142, 0.0022066610399633646, 0.013975140638649464, 0.005751077551394701, 0.014773271046578884, 0.002146749757230282, -0.013982377015054226, 0.004663135856389999, 0.00256434828042984, 0.06718125194311142, 0.021542755886912346, -0.014245148748159409, -0.0007380452007055283, 0.008497711271047592, -0.013817169703543186, -0.02069254405796528, 0.02084256336092949, -0.012179992161691189, 0.0003443772438913584, -0.00949414074420929, -0.007282701320946217, 0.00876117218285799, 0.003071058541536331, -0.0006613391451537609, -0.0010063746012747288, 0.0029621454887092113, -0.007640080526471138, -0.002617493737488985, 0.009986206889152527, -0.004988289438188076, 0.014744908548891544, 0.004585333168506622, 0.00794762559235096, -0.016876762732863426, -0.015271956101059914, 0.011851700954139233, 0.028003036975860596, -0.02286640554666519, 0.008162559010088444, -0.00776242557913065, -0.01083386316895485, -0.0018534841947257519, 0.006578278727829456, -0.0020863190293312073, -0.00583599042147398, -0.013564903289079666, -0.032943401485681534, 0.011120307259261608, -0.02608669176697731, -0.0164342038333416, 0.001211522496305406, 0.0033462790306657553, -0.00763486884534359, 0.00432433420792222, -0.004087130539119244, -0.01909075677394867, -0.006044337525963783, 0.008620146661996841, 0.00752625847235322, -0.0027882724534720182, 0.002488831989467144, -0.006214231718331575, -0.0040414780378341675, 0.004185115918517113, -0.009896054863929749, -0.006727287545800209, 0.008571282029151917, -0.007391210179775953, 0.003493324387818575, -0.00967194139957428, -0.004715811926871538, -0.030223626643419266, 0.020486798137426376, 0.011729503981769085, 0.02823852002620697, 0.022610515356063843, 0.00528310239315033, 0.018673257902264595, -0.004222734831273556, 0.004673811607062817, 0.0026350347325205803, -0.0014781825011596084, 0.03161855414509773, 0.012483160011470318, 0.026948750019073486, 0.00006878934800624847, 0.007094337604939938, -0.010705162771046162, 0.022650394588708878, -0.006255741696804762, 0.012366862036287785, 0.005043093580752611, 0.0012286126147955656, -0.005995581857860088, -0.008232028223574162, 0.014586612582206726, -0.007889464497566223, 0.023064229637384415, 0.023893941193819046, 0.002895649988204241, 0.0023917248472571373, -0.004411006346344948, -0.00025070353876799345, -0.081826351583004, -0.009529497474431992, 0.0028976285830140114, 0.005207637324929237, 0.0015472987433895469, 0.0019921325147151947, -0.005523995030671358, 0.009311133064329624, 0.001226948224939406, 0.0013676122762262821, 0.012268642894923687, 0.013046461157500744, -0.010206541046500206, 0.02515162155032158, 0.005775317084044218, 0.0067967805080115795, 0.0006064377957955003, 0.014279813505709171, -0.00991792045533657, 0.004288005642592907, -0.01585577242076397, 0.0031013356056064367, 0.00934977363795042, -0.027188584208488464, 0.03338954225182533, -0.014937433414161205, 0.0008753245929256082, -0.00004455028101801872, -0.008773218840360641, 0.0011503832647576928, 0.006649726070463657, -0.016179131343960762, 0.00654846616089344, -0.015468306839466095, -0.012097964063286781, -0.0003188543487340212, -0.0019775936380028725, 0.013577857054769993, -0.01292690634727478, 0.017027800902724266, -0.00876697525382042, 0.006443746853619814, 0.00016401195898652077, -0.007056230213493109, 0.003323434619233012, 0.004571623168885708, -0.006781592965126038, -0.004302570596337318, 0.011203659698367119, -0.00361825549043715, 0.025936082005500793, -0.007765587419271469, 0.02792733907699585, 0.005703932140022516, -0.016174621880054474, 0.018972735852003098, -0.005161279812455177, -0.023758405819535255, -0.009076585993170738, -0.012301243841648102, 0.00421625841408968, -0.011797715909779072, 0.0013724021846428514, -0.007926419377326965, -0.00845087505877018, -0.004280253313481808, -0.0023312922567129135, -0.01296607218682766, -0.005042215343564749, 0.0025994409807026386, -0.014454767107963562, -0.00912969559431076, -0.006690463051199913, -0.0036817332729697227, 0.00524787325412035, -0.007433472201228142, -0.009407367557287216, -0.006806656718254089, 0.017916535958647728, -0.00480977538973093, 0.004720467142760754, -0.0011449549347162247, -0.0020344052463769913, -0.01553301326930523, -0.005912542808800936, 0.0032660409342497587, 0.01338215172290802, 0.009249365888535976, 0.01782067120075226, -0.00502366479486227, -0.005191324278712273, 0.004886350128799677, -0.006077302619814873, 0.009153449907898903, 0.004842914175242186, -0.000894205819349736, 0.021305717527866364, -0.0156784076243639, 0.008141303434967995, 0.005104280076920986, -0.013341160491108894, -0.0067869448103010654, -0.012600060552358627, -0.010722389444708824, -0.0068607330322265625, 0.0070807551965117455, 0.012956226244568825, 0.011097914539277554, -0.017440946772694588, -0.0056282225996255875, 0.0023683984763920307, -0.02002156898379326, -0.004847717471420765, 0.002741248346865177, 0.0039423080161213875, 0.00028793513774871826, -0.0076607149094343185, -0.0008785934187471867, 0.07304617762565613, 0.00042430905159562826, 0.014347141608595848, -0.00643687229603529, 0.00962034147232771, -0.014916965737938881, 0.005185076966881752, 0.004396666772663593, -0.002875901060178876, 0.003710887860506773, 0.01018848828971386, -0.009010778740048409, 0.0004217240493744612, -0.00034180073998868465, -0.017901014536619186, 0.004668001085519791, 0.018260031938552856, 0.018761534243822098, 0.030455470085144043, -0.007426059804856777, 0.023430559784173965, 0.0028575449250638485, -0.0017310075927525759, -0.010999126359820366, 0.030204303562641144, -0.03983570262789726, -0.01072927750647068, -0.015247948467731476, -0.005277250427752733, 0.00374621688388288, 0.01104949600994587, 0.009038036689162254, -0.0067486995831131935, 0.0000817091204226017, 0.0050353710539639, 0.022108493372797966, 0.01725500449538231, 0.00787203386425972, 0.01625468209385872, -0.007204123307019472, -0.018837623298168182, -0.008376427926123142, -0.015750499442219734, 0.003066178411245346, -0.030842632055282593, 0.0009442793671041727, 0.003697260282933712, -0.004141543060541153, -0.013040300458669662, 0.01182702649384737, 0.0060599735006690025, 0.002287828829139471, 0.01205466128885746, 0.01726040616631508, -0.011144923977553844, -0.007487897761166096, 0.009577004238963127, -0.0068032583221793175, -0.003735547186806798, -0.018093662336468697, 0.010405558161437511, -0.0065536946058273315, 0.017624808475375175, -0.0031798286363482475, -0.021446146070957184, -0.0059267873875796795, 0.007664687931537628, -0.005935750901699066, -0.024218754842877388, -0.0036016693338751793, -0.011181550100445747, -0.0034532463178038597, -0.0029099471867084503, 0.007188339717686176, -0.00859756488353014, 0.009505249559879303, -0.02164435014128685, 0.010824549943208694, -0.010647246614098549, -0.019869733601808548, 0.0010490419808775187, -0.024616561830043793, 0.028274044394493103, 0.005453946068882942, 0.02476498670876026, 0.0006260483060032129, -0.01985008642077446, -0.07506953179836273, -0.010470934212207794, 0.009027433581650257, -0.009315041825175285, 0.006483588367700577, 0.01620277389883995, -0.01169496774673462, -0.02715015783905983, -0.016266342252492905, -0.0047284262254834175, -0.008948076516389847, -0.004449600353837013, -0.009137198328971863, -0.0045866407454013824, 0.01173725351691246, -0.0071453675627708435, -0.0010667734313756227, -0.005163406953215599, -0.005864621140062809, 0.007128912955522537, 0.024312105029821396, 0.005124986171722412, -0.006221608258783817, -0.008163942024111748, -0.00830511562526226, -0.08195118606090546, 0.010088772512972355, 0.0033527621999382973, -0.001036125235259533, -0.00022356444969773293, -0.012423688545823097, 0.007481497246772051, -0.005933466367423534, 0.02331717126071453, -0.015072471462190151, -0.003750275122001767, 0.0005457962397485971, -0.01504079531878233, -0.0037739111576229334, -0.008359373547136784, -0.0009506333735771477, 0.004793019033968449, 0.017571639269590378, 0.00723008019849658, -0.0203390009701252, -0.011576171964406967, 0.0005856303032487631, -0.002122442238032818, 0.008977032266557217, -0.0075753796845674515, 0.00906962901353836, -0.024264493957161903, 0.008474873378872871, 0.020654762163758278, -0.006446412764489651, 0.020097684115171432, 0.006852543447166681, -0.007058781571686268, -0.0008147989865392447, 0.0015368860913440585, -0.014617137610912323, 0.003873565001413226, -0.012521374970674515, 0.028569966554641724, -0.007130708545446396, 0.0008447926957160234, -0.006168917752802372, -0.004511761479079723, 0.015947256237268448, 0.007433399558067322, 0.0018803533166646957, 0.0069887819699943066, -0.008628441952168941, -0.0020200656726956367, 0.010126017034053802, 0.007795706391334534, 0.0006563267670571804, -0.0014976179227232933, 0.0025510061532258987, 0.002491365186870098, -0.003506997600197792, -0.004566793330013752, 0.01877182349562645, -0.002658060286194086, 0.004469951614737511, 0.0005336592439562082, -0.008116316050291061, 0.0008807409321889281, 0.07254843413829803, -0.015828020870685577, -0.0007582767866551876, 0.005326873157173395, 0.0014185670297592878, -0.005721075460314751, -0.01048341579735279, -0.007254677824676037, 0.01402638666331768, -0.01087501086294651, -0.010299650020897388, -0.007777588441967964, 0.011264803819358349, 0.006194190122187138, 0.0012916834093630314, -0.025927789509296417, 0.003476256038993597, 0.006952083669602871, -0.02099858969449997, -0.004995446652173996, -0.0032500247471034527, 0.036394376307725906, -0.051367759704589844, 0.011719721369445324, 0.013855928555130959, -0.003837818745523691, 0.011304590851068497, -0.013163638301193714, -0.005764584988355637, -0.008908456191420555, -0.011013610288500786, 0.00754193589091301, 0.007292488589882851, 0.00313752144575119, 0.017158061265945435, 0.01554109901189804, 0.011015893891453743, 0.0038663491141051054, -0.032103512436151505, 0.008315280079841614, 0.01480148732662201, 0.0008042082190513611, 0.004064176231622696, -0.006565802730619907, 0.011005930602550507, -0.017644410952925682, 0.005521206185221672, -0.025911439210176468, -0.005966966971755028, 0.010160226374864578, 0.0059584216214716434, 0.010291255079209805, 0.01371215470135212, 0.010982122272253036, -0.007505303714424372, 0.0008250554092228413, 0.0006263793911784887, 0.023987093940377235, -0.021977700293064117, 0.00037045753560960293, -0.0027075386606156826, -0.012076186947524548, -0.011522636748850346, -0.007263153325766325, 0.0016175624914467335, -0.01791226863861084, 0.010572230443358421, -0.015631988644599915, -0.007315703667700291, 0.006669838912785053, 0.008611678145825863, 0.020058995112776756, -0.002163499128073454, 0.027341272681951523, 0.0042788321152329445, -0.017365509644150734, -0.006192054599523544, -0.011169647797942162, 0.008349249139428139, 0.011470479890704155, -0.004937218502163887, 0.01146550290286541, 0.0008137961849570274, -0.03314366564154625, -0.006939674261957407, 0.007650441490113735, -0.01416981965303421, 0.011906103231012821, -0.005556620191782713, -0.0008855387568473816, -0.003423632588237524, 0.0018116161227226257, 0.004356863908469677, 0.0037461277097463608, 0.002150509040802717, 0.03357972204685211, -0.02048761025071144, 0.007227005902677774, 0.016226034611463547, -0.014181669801473618, -0.003357604146003723, -0.0037961541675031185, -0.006339644081890583, -0.0006767722079530358, 0.004098205827176571, 0.013159018941223621, 0.020528530701994896, -0.018134456127882004, 0.013851574622094631, 0.03119860775768757, -0.015269720926880836, -0.025053847581148148, 0.015744952484965324, 0.009023783728480339, 0.019856974482536316, 0.0035320145543664694, -0.0003224672982469201, -0.019369415938854218, 0.009048890322446823, -0.011359205469489098, -0.01875165104866028, -0.004981915932148695, 0.0036922278814017773, 0.030640795826911926, -0.0036858697421848774, -0.005946795456111431, -0.009415077045559883, -0.010107235983014107, -0.00365209742449224, 0.013072744943201542, 0.002466262551024556, -0.0018159830942749977, 0.01898709125816822, -0.012151991948485374, 0.006450626999139786, -0.019396072253584862, -0.020698552951216698, -0.003120292676612735, -0.007197624538093805, 0.010780731216073036, 0.006518727634102106, 0.0015993553679436445, 0.0008418513461947441, 0.002126893028616905, 0.010664435103535652, 0.012861053459346294, -0.00808965414762497, 0.019399529322981834, 0.00868681538850069, -0.014498469419777393, -0.0017646991182118654, -0.0039616855792701244, -0.006545362062752247, 0.0025229714810848236, -0.02793716825544834, 0.0008295872248709202, 0.01873812824487686, 0.015885991975665092, -0.0039035400841385126, -0.010044759139418602, 0.002430338878184557, -0.005434778518974781, 0.0009085512720048428, 0.007716397754848003, 0.01540728472173214, 0.0026216257829219103, -0.0074769360944628716, 0.00676536513492465, -0.004332952667027712, 0.011791343800723553, -0.010910664685070515, -0.007164709270000458, -0.004454579669982195, 0.03183632344007492, -0.0021264604292809963, 0.0018657140899449587, 0.012929572723805904, -0.0015383949503302574, -0.01347874291241169, 0.04151301458477974, 0.02214920148253441, -0.012601206079125404, -0.005345806013792753, -0.007555270567536354, -0.008678434416651726, -0.017915979027748108, 0.00003953860141336918, -0.019398881122469902, -0.00053432397544384, -0.013792721554636955, -0.007893314585089684, -0.0016791298985481262, -0.018773041665554047, -0.014483976177871227, 0.012182991951704025, -0.012943212874233723, -0.025009825825691223, -0.008251901715993881, 0.016849469393491745, 0.00016731140203773975, -0.003939994610846043, -0.00801495648920536 ]
[ 0.04769528657197952, 0.04729773476719856, 0.01502989511936903, 0.24071961641311646, -0.2018163800239563, 0.8434218764305115, 0.4648469388484955, -0.029743986204266548, -0.3890783190727234, -0.017268303781747818, 0.2730015218257904, 0.687495768070221, 0.017016828060150146, -0.2936604619026184, 0.05536146089434624, 0.597713828086853, 0.6136225461959839, 0.019655991345643997, 0.00423729233443737, -0.55905681848526, -0.19354870915412903, -0.3387225568294525, 0.4128066301345825, 0.06885380297899246, 0.002086543943732977, 0.5033485889434814, 0.46755725145339966, -0.1548386961221695, 0.05586029589176178, 0.04336665943264961, -0.09744121134281158, 0.4131588041782379, 0.4132387340068817, -0.06884454190731049, -0.26765021681785583, 0.39747294783592224, 0.20636245608329773, 0.11952301114797592, 0.3408838212490082, -0.32344910502433777, -0.10218174755573273, -0.2031686007976532, 0.05201144516468048, 0.3663076162338257, -0.3155394196510315, -0.35869425535202026, -1.828795313835144, -0.022136295214295387, -0.2045508772134781, 0.5483261346817017, -0.029331186786293983, 0.7045672535896301, 0.22642645239830017, 0.19555719196796417, 0.02802189067006111, 1.0355079174041748, -0.21687713265419006, -0.013840410858392715, -0.09574861079454422, -0.269601970911026, 0.062081921845674515, -0.3267401456832886, 0.3506923317909241, 0.28210708498954773, -0.3242761194705963, 0.13344739377498627, -0.20741447806358337, 0.18131084740161896, -0.04084610193967819, -0.13470377027988434, -0.29431167244911194, -0.5311145186424255, -0.4525907337665558, 0.1937069594860077, -0.30356037616729736, -0.44095462560653687, -0.409201443195343, 0.05741124972701073, 0.14832904934883118, -0.1974100023508072, 0.6466882824897766, 0.021927248686552048, 0.06882204860448837, -0.6448982357978821, 0.15802085399627686, 0.36651095747947693, 0.15384666621685028, 0.26307758688926697, -0.20398291945457458, 0.3268383741378784, -0.12770500779151917, -0.13968200981616974, 0.5423394441604614, 0.6912417411804199, -0.18194900453090668, 0.13484904170036316, 0.31339433789253235, -0.2786853611469269, 0.5317782759666443, 0.004573282320052385, -0.010180388577282429, -0.03519449383020401, 0.03853238746523857, 0.2950277626514435, -0.7684937715530396, 0.24788804352283478, -0.19417206943035126, -0.897621214389801, -0.7700668573379517, 0.19149070978164673, -0.6677793860435486, 0.6655813455581665, -0.08518967777490616, -0.042292747646570206, -0.4018925726413727, 0.16389837861061096, 0.20371143519878387, -0.47300395369529724, -0.03536274656653404, 0.28732940554618835, 0.0086789196357131, 0.3178573548793793, -0.021344611421227455, 0.18147988617420197, -0.027219004929065704, 0.2427414208650589, 0.3846976161003113, 0.31077873706817627, 0.24616649746894836, 0.48093634843826294, -0.17861637473106384, -0.07862717658281326, -0.2324531525373459, -0.16268354654312134, -0.1509394347667694, -0.44156354665756226, 0.10525565594434738, -0.3201306164264679, 0.11634155362844467, 0.029894046485424042, -0.4303731322288513, -0.7336562275886536, -0.10192017257213593, -0.4922008514404297, 0.276612251996994, -0.18021884560585022, 0.10649068653583527, 0.06792919337749481, -0.3755556643009186, -0.10431817173957825, 0.32607895135879517, 0.061854422092437744, -0.1938599944114685, -0.41848024725914, 0.08715241402387619, 0.48174670338630676, -0.6319513916969299, -0.2886904180049896, -0.2575545608997345, 0.055026691406965256, 0.4437676966190338, 0.4603915810585022, -0.4355928301811218, -0.1004505306482315, 0.33468782901763916, -0.06983204931020737, 0.2536718249320984, 0.021832242608070374, 0.15489712357521057, 0.15565477311611176, -0.23478703200817108, -0.3735719621181488, -0.01228695921599865, -0.0026838229969143867, -0.8502476215362549, -0.08024930953979492, 0.36526617407798767, 0.39882007241249084, 0.21206383407115936, 0.269192099571228, -0.46641600131988525, 0.2046200931072235, 0.38269859552383423, -0.49603912234306335, -0.04618481174111366, -0.07703123986721039, 0.5518302321434021, -0.21501943469047546, 0.3202551305294037, 0.2949301302433014, -0.03746907785534859, -0.21196602284908295, 0.487039178609848, -0.6826411485671997, 1.0594934225082397, -0.6621575355529785, -0.5046958327293396, 0.5789471864700317, -0.19324572384357452, -0.46600988507270813, 0.33296066522598267, 0.15690597891807556, 0.30447354912757874, -0.40827929973602295, -0.8433093428611755, -0.21632234752178192, 0.007397568318992853, -0.18200750648975372, -0.39198794960975647, 0.4585665464401245, -0.017290497198700905, -0.10016375035047531, -0.3645598292350769, -0.10024388879537582, 0.21681083738803864, 0.5270105600357056, -0.15069347620010376, 0.5235536098480225, 0.29402774572372437, -0.32067978382110596, 0.5788851380348206, -0.2863225042819977, 0.31819796562194824, 0.20209982991218567, 0.101957306265831, 0.3033437430858612, 0.9425564408302307, -0.050319332629442215, 0.6124215126037598, -0.7730088233947754, 0.5647217631340027, -0.12322469800710678, 0.659016489982605, -0.3550536334514618, 0.27506422996520996, 0.5161604881286621, -0.14077028632164001, -0.1529834121465683, 0.3305758237838745, 0.10345244407653809, -0.002082581864669919, 0.2657884657382965, -0.29401788115501404, 0.20254606008529663, 0.07235664874315262, -0.2667425870895386, -0.35364821553230286, 0.2071305215358734, -0.91014164686203, -0.3414459526538849, 0.009358402341604233, 0.36871710419654846, -0.003093272913247347, 0.32330015301704407, -0.07048583775758743, 0.006106482818722725, -0.10116206109523773, -0.35850989818573, 0.6414229273796082, -0.057238880544900894, -0.2530975043773651, -0.03247100114822388, 0.3525256812572479, -0.06542988121509552, 0.33745434880256653, -0.37605947256088257, -1.0259264707565308, -0.33247873187065125, 0.2736962139606476, 0.46999460458755493, 0.3958713114261627, 0.04398059844970703, -0.42599254846572876, 0.4588712155818939, 0.18774676322937012, -0.2885178327560425, 0.068524569272995, 0.6952944397926331, -0.9148030281066895, -0.5008348822593689, -0.04912308230996132, -0.3856961727142334, 0.6199809908866882, -0.10555224120616913, 0.3356873691082001, -0.35789409279823303, -0.04622878134250641, -0.6199514269828796, -0.2541447877883911, -0.5629053115844727, -0.20584183931350708, 0.8406926393508911, -0.28371942043304443, -0.7314629554748535, 0.8692600131034851, 0.16508643329143524, -0.4258376657962799, 0.6848279237747192, 0.7746122479438782, -0.17113974690437317, 0.4090597927570343, 0.11734873801469803, 0.05943497270345688, -0.45374757051467896, 0.25200018286705017, 0.09922980517148972, 0.04570109024643898, -0.19301266968250275, -6.1292643547058105, 0.1428268700838089, -0.9147050380706787, -0.13190147280693054, -0.5844280123710632, -0.07142126560211182, 0.8874053955078125, 0.07514119148254395, 0.1335788071155548, -0.22334499657154083, 0.6247971653938293, -0.12000981718301773, 0.2855713665485382, 0.444701611995697, -0.08519966900348663, 0.9427251815795898, 0.5808544158935547, -0.19365131855010986, 0.01240172702819109, 0.5711811184883118, 0.19131849706172943, -0.9480735063552856, -0.11984050273895264, 0.3890157639980316, 0.2952940762042999, 0.25242888927459717, -0.6517038941383362, 0.3149423897266388, 0.43151840567588806, 0.034554265439510345, 0.32930922508239746, -0.4144746661186218, -0.2985605299472809, -0.32959383726119995, 0.3450242877006531, 0.12366088479757309, 0.18019969761371613, 0.19908197224140167, 0.5657317042350769, -0.050754208117723465, 0.1345881223678589, 0.28321635723114014, -0.046640899032354355, -0.32320094108581543, 0.2935914695262909, -0.2392161637544632, 0.2316245287656784, 0.16294655203819275, -0.3407965898513794, 0.14921970665454865, 0.635263979434967, -0.19193822145462036, -0.2567887008190155, 0.3340781033039093, 0.049067988991737366, -0.1623479425907135, -0.09104948490858078, 0.7411840558052063, -0.3300713300704956, 0.5005969405174255, 0.2077394276857376, -0.03758784011006355, -0.10716268420219421, -0.7555012106895447, -0.4968120753765106, 0.012758709490299225, -0.455038458108902, -0.12508033215999603, 0.05712677538394928, -0.02673383615911007, -0.16031451523303986, -0.19078704714775085, 0.002711076522246003, -0.6538333892822266, -0.3291664123535156, -0.3451377749443054, 0.3572983145713806, 0.016072940081357956, -0.3191356360912323, -0.019612926989793777, -0.2237098515033722, -0.369758665561676, 0.4283905029296875, 0.27452343702316284, 0.3154532313346863, 0.23840032517910004, -0.1978936493396759, 0.31230607628822327, -0.691169798374176, -0.21234317123889923, -0.03523768112063408, -0.5239273309707642, 0.14611628651618958, 0.4230158030986786, 0.4115462899208069, 0.1288178265094757, 0.9282346367835999, -0.07558319717645645, 0.1422526240348816, -0.2615673840045929, 0.45407840609550476, -0.009549621492624283, -0.023777587339282036, -0.7259771227836609, -0.07867781817913055, -0.009342238306999207, -0.5589380860328674, -0.013394738547503948, 0.9347702860832214, -0.7664119005203247, -0.015072785317897797, -0.018493041396141052, -0.23689500987529755, -0.41860365867614746, 0.40265437960624695, 0.10953405499458313, -0.11996358633041382, -0.3444153964519501, 0.376149445772171, -0.03507965803146362, -0.01730252243578434, 0.27771177887916565, -0.36276450753211975, -0.20516018569469452, -0.6519148945808411, -0.6871231198310852, 0.17410776019096375, 0.429482102394104, -0.684168815612793, 0.340170681476593, -0.01718742400407791, 0.45522770285606384, -0.32719185948371887, 0.07335520535707474, 0.030414078384637833, -0.2050037682056427, -0.04470318555831909, 0.43551236391067505, 0.191552072763443, -0.11028538644313812, 0.2510927617549896, 0.06334810703992844, -0.027433890849351883, -0.07698488235473633, 0.09271494299173355, 0.0774121806025505, -0.28875672817230225, -0.5513945817947388, -0.3664010167121887, -0.1771993339061737, 0.09468305110931396, 0.0965275764465332, 0.19322223961353302, 0.19899997115135193, -0.32078418135643005, -0.15105707943439484, 0.17626938223838806, -0.1041763573884964, -0.056858599185943604, -0.5680426955223083, 0.8700774312019348, -0.13003139197826385, -0.7326235175132751, -0.38358184695243835, 0.1571885049343109, 0.39651522040367126, 0.31459665298461914, -0.07452627271413803, 0.05853154510259628, 0.3604698181152344, 0.38274240493774414, -0.7823164463043213, 0.03288464993238449, -0.09150034934282303, -0.33441659808158875, 0.033415645360946655, -0.2462889701128006, -0.46801331639289856, -0.15286239981651306, 0.07853954285383224, -0.1640794277191162, -0.7158738374710083, -0.3868871033191681, 0.06171876937150955, 0.40898439288139343, 0.2708824872970581, 0.035937655717134476, -0.09317333251237869, -0.14724388718605042, 0.18550486862659454, 0.005269052926450968, -0.35949280858039856, 0.5877087116241455, 0.21483173966407776, -0.4411908984184265, -0.4189267158508301, 0.044232141226530075, 0.2840125560760498, -0.34703776240348816, 0.01709226332604885, -0.13111044466495514, 0.02339741960167885, -0.1901945024728775, 0.17955540120601654, 0.36067113280296326, -0.34328725934028625, -0.1917918622493744, -0.05161719769239426, -0.3207332193851471, -0.45023736357688904, -0.20477956533432007, -0.2984795570373535, -0.20597489178180695, 0.41409385204315186, -0.006158897187560797, 0.4207835793495178, 0.04314033314585686, 0.015043497085571289, -0.21015912294387817, 0.2121930569410324, 0.7009837627410889, 0.20310497283935547, -0.5345402359962463, -0.10462628304958344, 0.0056332373060286045, 0.2677684426307678, 0.7761242389678955, -0.7453035712242126, 0.06188059225678444, 0.263848215341568, -0.6496042013168335, 0.1266355663537979, 0.024151137098670006, -0.07728799432516098, -0.4222269654273987, 0.15276813507080078, -0.36499595642089844, 0.3410007059574127, 0.1612231731414795, -0.31126463413238525, -0.5235639214515686, 0.7094220519065857, 0.016977369785308838, -0.09009891748428345, 0.16504152119159698, 0.19286522269248962, -0.09957913309335709, -0.2600518465042114, -0.2599223852157593, 0.0970800593495369, -0.2705127000808716, -0.5608974695205688, 0.14940552413463593, -0.1344887614250183, 0.3339405059814453, 0.14455558359622955, -0.3528471291065216, -0.09239813685417175, -0.23313884437084198, 0.18966692686080933, 0.04030480608344078, 0.014211769215762615, -0.3649120032787323, -0.15605105459690094, 0.21490533649921417, 0.285492867231369, -0.030435385182499886, -0.388400673866272, 0.0006492449319921434, -0.345101922750473, 0.5667718052864075, 0.04677833616733551, -0.2450162172317505, 0.5008801817893982, 0.23525279760360718, -0.09593807905912399, -0.08249269425868988, -0.05919315665960312, 0.010121510364115238, 0.005338349379599094, -0.3370473384857178, -0.5504528880119324, 0.2583753764629364, 0.11801940947771072, 0.45213380455970764, -0.5872642397880554, -0.06367941945791245, -0.1677229255437851, -0.7574426531791687, -0.4157688319683075, 0.21284760534763336, 0.07987653464078903, -0.5882750749588013, -0.7459847927093506, -0.4531627595424652, 0.3869078755378723, 0.17477765679359436, 0.2001442015171051, -0.18831166625022888, -0.15542151033878326, -0.1324853003025055, 0.6087895631790161, 0.40614309906959534, -0.2840765118598938, -0.08142956346273422, 0.11916947364807129, -0.006790779065340757, -0.22482645511627197, -0.22547034919261932, -0.008885332383215427, 0.22974002361297607, -0.16374699771404266, 0.5676817297935486, 0.42107459902763367, -0.6508301496505737, 0.19008059799671173, -0.32153645157814026, 0.01787424460053444, 0.6791879534721375, 0.5069947242736816, -0.06675217300653458, 0.36360371112823486, 0.6741546988487244, 0.10688573122024536, 0.07440339773893356, 0.14722122251987457, 0.10810503363609314, 0.5357096791267395, 0.05685308948159218, 0.5328149795532227, 0.5339049696922302, 0.35926324129104614, -0.0001313054235652089, 0.6272846460342407, -0.07639964669942856, 0.3140201270580292, -0.43478095531463623, -0.501714825630188, -0.22497791051864624, 0.05210176110267639, 1.066200852394104, 0.5489391088485718, 0.289056658744812, -0.379639208316803, -0.17048555612564087, 0.15407033264636993, -0.4630868136882782, 0.16160571575164795, -0.2083328813314438, 0.17632542550563812, 0.18615996837615967, -0.15070104598999023, -0.07609933614730835, -0.13808344304561615, -0.469698429107666, -0.08292758464813232, -0.15259529650211334, -0.13294407725334167, -0.697447657585144, -0.03811420872807503, -0.1163860335946083, 0.5020178556442261, -0.0014021998504176736, -0.19749754667282104, -0.6160904765129089, -0.32309597730636597, 0.3666556775569916, 0.13077042996883392, -0.07442030310630798, 0.22861137986183167, -0.16964536905288696, 0.03253403678536415, -0.08533898741006851, 0.046981364488601685, 0.33097827434539795, -0.02467331290245056, -0.09651961177587509, -0.07453253120183945, 0.19464929401874542, 0.38250476121902466, -0.22480182349681854, -0.3183302879333496, 0.006495481822639704, -0.4233227074146271, -0.25309476256370544, 0.1171342059969902, -0.2543691396713257, 0.18762321770191193, 0.2021188884973526, -0.04047049209475517, -0.06610618531703949, -0.14755995571613312, 0.40091484785079956, 0.17702436447143555, 0.06938593089580536, -0.0672200545668602, -0.23250414431095123, 0.18815653026103973, 0.49540579319000244, 0.46551209688186646, -0.2245844155550003, -0.3252074420452118, -0.18980808556079865, 0.020057905465364456, -0.11207021027803421, 0.6666213870048523, -0.1966501623392105, 0.2997313141822815, -0.2816046178340912, -0.02694934792816639, 0.5190662741661072, -0.11199386417865753, -0.2939731180667877, -0.03380540758371353, 0.0935509204864502, 0.06634819507598877, 0.5414350032806396, -0.020750079303979874, -0.23432354629039764, -0.29912376403808594, -0.46076953411102295, -0.4333812892436981, 0.30141595005989075, -0.03255780041217804, -0.2977665960788727, -0.011821512132883072, -0.04048490896821022, 0.1990383118391037, 0.1300750970840454, 0.29797106981277466, -0.15162359178066254, -0.34543782472610474, -0.24253727495670319, 0.04076588898897171, -0.44597363471984863, 0.010139035992324352, 0.2969827353954315, 0.23734799027442932, 0.10315993428230286, -0.17735974490642548, -0.2917385399341583, -0.23993703722953796, 0.40859606862068176, -0.01978784054517746, 0.6107804179191589, 0.44055092334747314, 0.39951756596565247, -0.3957434892654419, -0.3687419593334198, 0.8594823479652405, -0.4470277428627014, -0.17033107578754425, -0.4314512014389038, 0.08407146483659744, -0.11245859414339066, -0.0684911385178566, 0.45402124524116516, -0.455841064453125, -0.0837506651878357, -0.2631426155567169 ]
BACKGROUND MicroRNA-196 (miR-196), which is highly up-regulated in oral cancer cells, has been reported to be aberrantly expressed in several cancers; however, the significance of miR-196 in oral cancer has not yet been addressed. METHODS Cellular functions in response to miR-196 modulation were examined, including cell growth, migration, invasion and radio/chemosensitivity. Algorithm-based studies were used to identify the regulatory target of miR-196. The miR-196 target gene and downstream molecular mechanisms were confirmed by RT-qPCR, western blot, luciferase reporter and confocal microscopy analyses. miR-196 expression was determined in paired cancer and adjacent normal tissues from oral cancer patients. RESULTS Both miR-196a and miR-196b were highly over-expressed in the cancer tissue and correlated with lymph node metastasis (P = 0.001 and P = 0.006, respectively). Functionally, miR-196 actively promoted cell migration and invasion without affecting cell growth. Mechanistically, miR-196 performed it's their function by inhibiting NME4 expression and further activating p-JNK, suppressing TIMP1, and augmenting MMP1/9. CONCLUSION miR-196 contributes to oral cancer by promoting cell migration and invasion. Clinically, miR-196a/b was significantly over-expressed in the cancer tissues and correlated with lymph node metastasis. Thus, our findings provide new knowledge of the underlying mechanism of cancer metastasis. miR-196 may serve as a promising marker for better oral cancer management.
[ -0.0006613410077989101, -0.006680979393422604, -0.027910981327295303, 0.011852084659039974, 0.018333349376916885, -0.0034277369268238544, 0.008258244022727013, -0.0019279742846265435, -0.009689724072813988, -0.044894441962242126, -0.0057957349345088005, 0.003623753320425749, -0.011827278882265091, 0.02116018906235695, -0.01294301263988018, 0.01996518298983574, -0.04278750717639923, -0.008782623335719109, 0.00955989770591259, 0.020766455680131912, 0.033497754484415054, 0.007557107601314783, 0.007840328849852085, 0.015635784715414047, 0.027272921055555344, 0.007198895327746868, -0.002009014133363962, -0.004591710399836302, -0.017618831247091293, -0.014881368726491928, -0.012364691123366356, -0.02150549739599228, 0.028380995616316795, -0.009358825162053108, 0.022607523947954178, -0.030054636299610138, -0.007746745366603136, 0.01207503117620945, 0.025733111426234245, -0.004840871784836054, 0.006802458316087723, -0.015066397376358509, 0.0065749408677220345, 0.0002977694966830313, -0.00845428928732872, -0.027601201087236404, -0.004343343432992697, 0.012081834487617016, 0.02104959636926651, 0.005164711736142635, -0.0010923664085566998, -0.00113245053216815, -0.012111969292163849, 0.06725507974624634, -0.00420759990811348, 0.03959251940250397, 0.014694510027766228, 0.024287473410367966, 0.005134474486112595, 0.013874256983399391, 0.002594912424683571, -0.008906932547688484, -0.0076811364851891994, -0.06247235834598541, -0.0027045104652643204, -0.06698276847600937, 0.002529960125684738, -0.0028544836677610874, 0.000422085402533412, 0.014703173190355301, -0.02194870263338089, 0.01371187623590231, -0.007281797006726265, -0.01870560459792614, 0.009887367486953735, -0.01559790875762701, -0.0054015726782381535, 0.004613983910530806, -0.004047813825309277, 0.01362200453877449, -0.00905488058924675, 0.0005225490313023329, -0.028684740886092186, -0.003617869922891259, 0.023506078869104385, 0.007085955236107111, -0.026739470660686493, -0.01951308362185955, -0.010097894817590714, -0.0018752564210444689, 0.01473232451826334, 0.011710163205862045, -0.02228235825896263, -0.019101738929748535, -0.060008276253938675, -0.001113582868129015, -0.005962652154266834, -0.01706225611269474, 0.017825910821557045, 0.006909766234457493, -0.023343920707702637, 0.016311196610331535, 0.012785689905285835, 0.007391017861664295, -0.020358985289931297, 0.007915868423879147, 0.011614162474870682, 0.009169289842247963, 0.002920728176832199, 0.007318624295294285, -0.010179830715060234, -0.009868111461400986, -0.005037789698690176, 0.016911057755351067, -0.007055885158479214, -0.001100996509194374, 0.007890189066529274, 0.0033264150843024254, 0.012528955936431885, 0.006030251272022724, -0.015868816524744034, -0.007103991229087114, 0.006003651302307844, 0.010768995620310307, 0.00428173691034317, 0.015301322564482689, 0.010271991603076458, -0.0029120533727109432, -0.015561791136860847, 0.0047475118190050125, -0.008236510679125786, 0.0047598653472959995, 0.009089547209441662, -0.044810276478528976, -0.0037263398990035057, -0.0005657139699906111, 0.01402808167040348, -0.009099441580474377, -0.007421948481351137, -0.012249279767274857, 0.013647252693772316, 0.011449852958321571, 0.006370146758854389, 0.010852420702576637, 0.010431076399981976, -0.008571527898311615, 0.003913492895662785, -0.008383918553590775, 0.03882259503006935, -0.022303177043795586, -0.010920518077909946, -0.020361213013529778, 0.009992027655243874, -0.02240445464849472, 0.023232046514749527, -0.007071289699524641, -0.03135717660188675, -0.016050107777118683, -0.003503947053104639, 0.0032445304095745087, -0.006553059909492731, -0.01173689216375351, 0.022882599383592606, 0.007983166724443436, 0.0016456792363896966, 0.021480770781636238, 0.0042315879836678505, -0.008027046918869019, -0.006814735475927591, 0.0046746619045734406, 0.0010888174874708056, -0.0007406111108139157, 0.006237948313355446, 0.012490319088101387, -0.01850917562842369, 0.0014391846489161253, -0.003711806144565344, 0.007469510193914175, 0.007868466898798943, 0.06690861284732819, 0.003963331691920757, 0.0015894384123384953, 0.03487558290362358, -0.02641621045768261, -0.032250188291072845, -0.01418289914727211, -0.018290497362613678, -0.009846827015280724, -0.021739628165960312, -0.0013704104349017143, 0.008797547779977322, 0.028217121958732605, -0.0537356361746788, 0.015035483986139297, -0.02416423335671425, 0.002501237438991666, 0.010716721415519714, 0.012738083489239216, 0.022326365113258362, -0.015502048656344414, -0.0046675787307322025, 0.009850233793258667, 0.02229834347963333, -0.01754041761159897, -0.01846105232834816, -0.014573471620678902, 0.019974883645772934, -0.04637046903371811, 0.018023166805505753, 0.03771040961146355, 0.010070985183119774, -0.01458258368074894, -0.01186501607298851, -0.015220193192362785, 0.0031519224867224693, 0.021343711763620377, 0.0118087287992239, 0.015055438503623009, 0.005787873174995184, -0.010131914168596268, 0.00217830971814692, 0.0024922362063080072, 0.004204799421131611, -0.006143956445157528, 0.02418336644768715, -0.007429514080286026, -0.0014765379019081593, 0.011760123074054718, 0.015053954906761646, 0.002788218203932047, -0.00433453219011426, -0.025584029033780098, -0.012051362544298172, 0.016320647671818733, 0.020979855209589005, -0.005524719133973122, 0.012749921530485153, -0.004841853864490986, 0.006833829917013645, -0.011666707694530487, -0.001831674948334694, 0.02233761176466942, 0.015555941499769688, -0.02565508335828781, 0.0141684515401721, -0.0012252372689545155, -0.0001687612384557724, 0.002332438249140978, 0.03367125242948532, -0.01097924541682005, 0.010423120111227036, -0.013308835215866566, 0.0325750894844532, -0.0056276507675647736, 0.05204444006085396, 0.0254107266664505, -0.00548298517242074, 0.013040991500020027, 0.021507995203137398, -0.014466848224401474, 0.0044607906602323055, 0.00787707231938839, 0.005301564931869507, -0.005380857270210981, 0.02600158378481865, 0.05073150247335434, 0.0025334488600492477, 0.0034885085187852383, -0.009063691832125187, -0.0012968245428055525, 0.008831759914755821, -0.011350352317094803, -0.002334871329367161, -0.08108745515346527, -0.011814307421445847, 0.016623176634311676, 0.018204936757683754, 0.01031879335641861, -0.014333991333842278, 0.0012760721147060394, 0.02464354783296585, -0.0009592319838702679, 0.013586887158453465, -0.003944446332752705, 0.029221657663583755, -0.01130660716444254, -0.02526579238474369, 0.004089075140655041, -0.006202551070600748, 0.014785759150981903, 0.016474878415465355, -0.005311810411512852, 0.008467189036309719, 0.000308220274746418, 0.012007108889520168, -0.0026019196957349777, 0.015683157369494438, -0.016722332686185837, -0.01834026910364628, -0.008799022063612938, 0.003937562461942434, 0.001502246130257845, -0.0034003043547272682, -0.0028188079595565796, -0.010578412562608719, 0.04419179633259773, 0.005087480880320072, 0.003918629139661789, 0.0212207343429327, 0.013529250398278236, -0.001835732371546328, -0.026450442150235176, 0.03649109601974487, -0.006310943979769945, 0.0011326017556712031, 0.025648165494203568, -0.0032924190163612366, 0.007140870206058025, 0.016179891303181648, -0.005972270388156176, 0.04780690744519234, 0.015176095068454742, -0.017567547038197517, -0.0046966844238340855, 0.003440615488216281, -0.023602185770869255, 0.020075390115380287, -0.018430747091770172, 0.019922109320759773, -0.03164680302143097, -0.02527967467904091, -0.0056051225401461124, -0.011715399101376534, 0.001109628938138485, -0.007578336633741856, 0.025388307869434357, 0.03171350806951523, -0.008939357474446297, -0.011293633840978146, 0.002126493491232395, -0.015705792233347893, -0.038448117673397064, 0.0068461839109659195, 0.016549116000533104, 0.007559664081782103, -0.006531372666358948, -0.013912429101765156, 0.017421085387468338, -0.013338927179574966, -0.01509783323854208, 0.004315631929785013, 0.017526952549815178, -0.008129697293043137, 0.0028884713537991047, -0.005581479519605637, -0.02321949414908886, 0.012161001563072205, -0.02168365940451622, -0.017664901912212372, 0.001779712038114667, 0.020117413252592087, 0.013713832013309002, -0.009808123111724854, 0.03820192813873291, -0.0011669511441141367, -0.0030667195096611977, 0.00890067033469677, 0.0160744059830904, -0.008898263797163963, -0.006021738983690739, 0.01964893564581871, 0.01858668029308319, 0.007722572423517704, -0.013795391656458378, -0.0014152808580547571, -0.016031650826334953, -0.010368162766098976, -0.014450663700699806, 0.009096289053559303, -0.01224546879529953, -0.026098402217030525, 0.006976689212024212, -0.0016735013341531157, -0.007030901499092579, -0.012996447272598743, -0.006372549571096897, 0.03354378789663315, 0.00404770253226161, 0.0361037477850914, -0.014259186573326588, 0.0057864016853272915, 0.07267938554286957, 0.004018993116915226, 0.0044600386172533035, -0.015174482949078083, 0.017077822238206863, -0.01457298081368208, -0.020918549969792366, 0.014462639577686787, -0.048941370099782944, 0.00953722558915615, 0.009279677644371986, 0.0030479219276458025, 0.025017619132995605, -0.02983660064637661, 0.019780272617936134, 0.027632616460323334, 0.004059353843331337, 0.0208846814930439, 0.029599115252494812, 0.017422402277588844, -0.036764975637197495, 0.006515503395348787, -0.014355052262544632, -0.0132848359644413, -0.0074581000953912735, 0.015788190066814423, 0.0005608962383121252, -0.012013942003250122, -0.014429397881031036, 0.013402820564806461, 0.00568684795871377, -0.01099468395113945, -0.0074561829678714275, 0.005228599067777395, -0.004469752311706543, 0.002911703661084175, 0.009939171373844147, -0.00991842895746231, 0.0047950767911970615, -0.0034625858534127474, 0.0026044254191219807, -0.012073474004864693, 0.029453005641698837, 0.009068083018064499, -0.025239920243620872, -0.009265542961657047, 0.023411989212036133, -0.00911956001073122, 0.002545862691476941, -0.004547795280814171, -0.00593971461057663, -0.004179215058684349, 0.01180160604417324, 0.007015647366642952, -0.026629861444234848, -0.012156129814684391, 0.016711585223674774, -0.0013878336176276207, -0.004809406120330095, -0.05777866393327713, -0.004367395769804716, 0.016962911933660507, 0.014230703935027122, 0.00013973843306303024, 0.029228240251541138, -0.02150173857808113, -0.022749800235033035, -0.009899664670228958, 0.02048591524362564, -0.011943050660192966, 0.020926492288708687, 0.0016381703317165375, -0.03803103417158127, -0.009886270388960838, -0.017864901572465897, 0.00846422091126442, 0.0198624636977911, 0.02171795442700386, 0.013408373109996319, -0.000476327259093523, 0.029859792441129684, 0.00198310986161232, 0.02292703092098236, -0.015154900960624218, 0.011301035061478615, 0.02246841974556446, -0.03378153592348099, -0.0746731162071228, -0.02354317717254162, 0.0009357021190226078, -0.008863866329193115, 0.008739173412322998, 0.011017685756087303, -0.018585151061415672, -0.02556786872446537, -0.027839623391628265, -0.004278906155377626, 0.008858466520905495, 0.0032354695722460747, 0.00003055867273360491, 0.0006705252453684807, 0.010471167042851448, -0.00448071863502264, -0.018657095730304718, 0.0002956944517791271, -0.0012083849869668484, 0.0432719811797142, 0.007469911128282547, -0.004775588866323233, -0.012033291161060333, 0.000028432346880435944, -0.00731044402346015, -0.0813538059592247, -0.013099568895995617, 0.010352442041039467, 0.003224432934075594, -0.014987904578447342, 0.004682579077780247, 0.04382570832967758, -0.013767661526799202, -0.028359560295939445, -0.014848919585347176, 0.004126060754060745, 0.0015283804386854172, -0.006786556914448738, -0.0224776454269886, -0.0038386802189052105, -0.011777766980230808, 0.009065656922757626, -0.0020854417234659195, -0.0007251137867569923, -0.006628771312534809, 0.012395301833748817, 0.014264125376939774, -0.0052473898977041245, -0.012825806625187397, -0.009224276058375835, -0.007098827976733446, -0.006061511114239693, 0.014412427321076393, -0.014433762058615685, -0.024064449593424797, -0.0016963272355496883, -0.006241532042622566, -0.013273801654577255, -0.03653622418642044, -0.00300843664444983, -0.015160474926233292, -0.00746586499735713, -0.0027097323909401894, -0.034737687557935715, -0.014099040068686008, -0.0076056960970163345, 0.029864218086004257, -0.007973143830895424, 0.007518081460148096, 0.0007959986105561256, -0.02688971906900406, 0.008639415726065636, -0.007995018735527992, 0.01727098785340786, 0.026107700541615486, 0.011501419357955456, -0.019884226843714714, 0.0003575938753783703, -0.0030497759580612183, 0.015534946694970131, 0.009345784783363342, -0.009530395269393921, 0.013171781785786152, -0.00463035237044096, 0.003083729650825262, 0.008507129736244678, 0.02566596306860447, 0.009060031734406948, 0.0722041130065918, 0.005097521934658289, 0.004300274886190891, -0.004789931699633598, -0.017062563449144363, 0.006897631101310253, -0.002079762052744627, -0.02846854366362095, 0.00855613499879837, -0.015002891421318054, -0.0027922785375267267, -0.0006119315512478352, 0.005610622465610504, 0.010323802009224892, -0.015113959088921547, 0.005173150449991226, -0.01509045995771885, 0.006639478728175163, -0.010033685714006424, 0.011155955493450165, -0.0036630025133490562, -0.006989678367972374, 0.004498246591538191, 0.0019526141695678234, -0.0017737401649355888, -0.007226090878248215, -0.013945660553872585, -0.0014391513541340828, -0.0007412121631205082, 0.019032221287488937, 0.0022997213527560234, -0.01453727949410677, 0.003652290441095829, -0.011721868999302387, 0.019198622554540634, 0.033320821821689606, -0.023166684433817863, 0.015580940991640091, -0.010329611599445343, -0.04654311388731003, -0.003635645378381014, -0.018848896026611328, 0.0022519920021295547, -0.0202048197388649, 0.003243406303226948, -0.025539983063936234, -0.005346405319869518, 0.005268942564725876, 0.002272350713610649, 0.006765705533325672, -0.003983292728662491, 0.002660992555320263, 0.00008362578228116035, -0.011899908073246479, 0.008278857916593552, 0.0010509095154702663, -0.041389890015125275, 0.008396081626415253, -0.01819763146340847, -0.008128996938467026, 0.012568583711981773, -0.013608252629637718, 0.017666857689619064, -0.018687622621655464, 0.03093882091343403, -0.02732742391526699, 0.025739677250385284, -0.024133794009685516, -0.0011430818121880293, 0.015125107020139694, -0.009650942869484425, 0.006002551410347223, 0.012921545654535294, 0.0021143280901014805, 0.017829759046435356, 0.011813312768936157, 0.00796782411634922, -0.025273889303207397, 0.01547149010002613, 0.01183951087296009, -0.019523045048117638, -0.002708504907786846, -0.008639000356197357, -0.028518831357359886, -0.016031352803111076, 0.03977445513010025, 0.01290119718760252, 0.01605943590402603, -0.005881045944988728, 0.010808738879859447, 0.024569569155573845, 0.016062624752521515, 0.003332883585244417, 0.007845079526305199, 0.0025268811732530594, 0.032735902816057205, 0.0086474334821105, 0.006258724723011255, -0.023015007376670837, 0.013272138312458992, 0.0349714457988739, 0.005246209446340799, -0.0013211537152528763, 0.04784240201115608, -0.01264548022300005, -0.011999118141829967, -0.006072981283068657, 0.01740080676972866, -0.010537654161453247, -0.013058791868388653, 0.006597804371267557, 0.02298864535987377, -0.009971393272280693, 0.011156473308801651, -0.014121148735284805, 0.025285223498940468, -0.005066311918199062, -0.013511011376976967, 0.027244575321674347, -0.015029145404696465, 0.003360261209309101, 0.01136649027466774, -0.019941244274377823, 0.015307283028960228, 0.00789338257163763, -0.007822147570550442, -0.007134455256164074, 0.04949382320046425, 0.027933599427342415, -0.005980153568089008, 0.011762432754039764, 0.034213896840810776, -0.01114171277731657, -0.0003002244047820568, -0.006069249473512173, 0.039534732699394226, -0.010777784511446953, -0.0027750483714044094, -0.006885891780257225, 0.015430946834385395, -0.02307579293847084, -0.02916155755519867, -0.0014302653726190329, 0.004251324571669102, 0.007825791835784912, 0.011321728117763996, 0.011435132473707199, 0.005783080123364925, -0.001993305515497923, -0.01279732771217823, 0.03237120434641838, 0.01317400112748146, -0.001126948744058609, -0.006765092723071575, -0.0006880620494484901, 0.012597061693668365, -0.010860510170459747, 0.018892500549554825, -0.020088329911231995, 0.008342582732439041, 0.006244550924748182, -0.000015834462828934193, 0.01025403942912817, -0.0178099162876606, 0.007877489551901817, -0.012244133278727531, 0.018277309834957123, 0.006216466426849365, -0.006012267433106899, -0.04056224972009659, 0.02255096286535263, -0.018468491733074188, -0.03134208917617798, 0.022038687020540237, -0.009725691750645638, 0.0006039001746103168, -0.01504550501704216, -0.014385064132511616, -0.007454552222043276, 0.0032152526546269655, -0.009818273596465588, -0.02366759069263935, 0.00696862768381834, -0.007913956418633461, 0.000544968293979764, 0.0016172723844647408, -0.008861245587468147, 0.012253250926733017, 0.010422625578939915, -0.006876848172396421, -0.02096482738852501, -0.01462296862155199, 0.004141677170991898, 0.01462689507752657, -0.03171848505735397, 0.0010216995142400265, 0.014286455698311329, -0.005479874089360237, 0.0054568215273320675, -0.004181141033768654, -0.009021304547786713, -0.017159724608063698 ]
[ 0.16508594155311584, -0.2221185564994812, 0.025421690195798874, -0.01937701553106308, 0.4167478382587433, 0.1450858861207962, 0.1766321361064911, 0.18789713084697723, -0.11826837807893753, -0.482382595539093, -0.10369479656219482, 0.31998956203460693, -0.7789056897163391, 0.07660999149084091, -0.056718118488788605, 0.44470974802970886, 0.5177260041236877, 0.33641335368156433, -0.21767699718475342, -0.7489871978759766, -0.16634276509284973, -0.036800578236579895, 0.8466697931289673, -0.10341577231884003, 0.044536884874105453, -0.03549664467573166, 0.5009113550186157, 0.13834266364574432, 0.3411809206008911, 0.11726443469524384, -0.7222965359687805, 0.7598116397857666, 0.28052955865859985, -0.17094658315181732, 0.3567945957183838, -0.07414917647838593, -0.27785995602607727, 0.17210115492343903, 0.07063734531402588, -0.0351891927421093, -0.28108111023902893, -0.27781152725219727, -0.3069656491279602, 0.7377744913101196, 0.15226775407791138, 0.10313289612531662, -1.1061476469039917, 0.6952934861183167, -0.39091041684150696, -0.5158332586288452, 0.2403893917798996, 0.4030717611312866, 0.37842804193496704, 0.33626875281333923, 0.5547962784767151, -0.07335718721151352, -0.756889283657074, -0.2629942297935486, 0.37691256403923035, -0.249800443649292, -0.026300445199012756, 0.01380104199051857, -0.5450829863548279, 0.23423081636428833, -0.21600352227687836, 0.5833859443664551, 0.04446947202086449, -0.5460717082023621, -0.16753393411636353, -0.6188227534294128, 0.2103552371263504, 0.18130163848400116, -0.2810301184654236, -0.12086271494626999, -0.04912363365292549, 0.4372289180755615, -0.17537496984004974, 0.06752753257751465, 0.12465028464794159, -0.3041573762893677, -0.20426185429096222, 0.015606996603310108, 0.35521256923675537, -0.17112435400485992, 0.5383312702178955, -0.3157995343208313, -0.21182003617286682, 0.6743950843811035, -0.17284661531448364, -0.03147286921739578, -0.1470288634300232, -0.15682564675807953, 0.32144856452941895, 0.8753395080566406, -0.05815523490309715, 0.09219088405370712, -0.2838362157344818, 0.01860547997057438, 0.21720120310783386, 0.13543091714382172, -0.6488169431686401, 0.5371734499931335, -0.04857562109827995, -0.569645345211029, -0.1938028186559677, -0.24497279524803162, 0.009532389231026173, -0.3824526369571686, -0.657771110534668, 0.615426778793335, -0.7111416459083557, 0.0367642417550087, -0.4264580011367798, -0.4951961040496826, 0.07265336811542511, 0.20962704718112946, 0.24152082204818726, -0.8132694363594055, 0.349321186542511, 0.4738606810569763, 0.13783037662506104, 1.5066566467285156, -0.07502223551273346, 0.3849368989467621, 0.10721003264188766, 0.09686195850372314, 0.6050915122032166, -0.5243601202964783, -0.1359892636537552, 0.6720607876777649, 0.6015585064888, 1.1760845184326172, -0.7792201638221741, 0.27477937936782837, 0.08481740206480026, -0.003453056327998638, 0.5431472659111023, 0.057889390736818314, 0.8196081519126892, 0.2503141760826111, -0.4745144844055176, -0.34116750955581665, -0.27619725465774536, 0.10851351916790009, -0.004336385056376457, -0.09992976486682892, 0.21403108537197113, -0.3000422418117523, 0.0010845946380868554, -0.19819019734859467, 0.0417192243039608, -0.3938281238079071, -0.754206120967865, -0.05000446364283562, -0.5341461896896362, 0.055989619344472885, 0.08543752878904343, -0.1493108719587326, -0.3692822754383087, 0.595069944858551, 0.33258891105651855, 0.014058740809559822, -0.4488309323787689, -0.059985920786857605, 0.7871143817901611, -0.1763315498828888, 0.15009628236293793, 0.46772199869155884, 0.11785081028938293, -0.153819739818573, -0.6185222864151001, -0.34404492378234863, 0.16110076010227203, -1.1598565578460693, 0.2330435812473297, 0.10030168294906616, 0.36890581250190735, -0.3914864957332611, 0.004821385256946087, -0.19782617688179016, -0.9275956749916077, -0.27249613404273987, 0.06125080958008766, -0.2673662006855011, 0.5979849696159363, 0.453497052192688, 0.6718629598617554, 0.45515018701553345, 0.12997661530971527, -0.17826049029827118, -0.7068442106246948, -0.29638582468032837, 0.8039067983627319, -0.33773866295814514, 1.0869503021240234, -0.13548044860363007, -0.03804787993431091, 1.4166885614395142, 0.22873902320861816, 0.04092790558934212, -0.23704449832439423, 0.09466095268726349, 0.6012446284294128, -0.3238885700702667, -0.4767891466617584, -0.25239965319633484, -0.18112713098526, -0.1953258067369461, 0.20895834267139435, 0.1555478721857071, 0.5853307843208313, -0.4511006474494934, -0.22461481392383575, 0.14761307835578918, 0.3394896686077118, -0.2970423698425293, -0.1152162104845047, -0.06145143136382103, -0.24428613483905792, 0.22002464532852173, 0.39376652240753174, -0.5032752752304077, 0.6214405298233032, 0.8008734583854675, -0.06574829667806625, 0.8934136629104614, 0.4412848949432373, 0.034215837717056274, 0.5364660620689392, 0.012374557554721832, 0.20620323717594147, -0.5609909892082214, -0.03828445449471474, -0.4320553243160248, -0.10822265595197678, 0.14191105961799622, 0.07627078890800476, 0.06211225315928459, 0.034903064370155334, -0.10666079819202423, -0.4367755055427551, 0.7281023859977722, -0.8039143681526184, -0.023969579488039017, -0.3896312117576599, -0.33669719099998474, -0.3789270520210266, -0.05534859001636505, -1.0246286392211914, 0.17413271963596344, -0.07702277600765228, 0.18207776546478271, -0.10208609700202942, -0.6982980966567993, -0.4181622266769409, 0.5703417062759399, -0.33531972765922546, -0.4122683107852936, 0.08380528539419174, -0.2845165729522705, -0.2202719748020172, 0.20299658179283142, 0.14592793583869934, 0.3462912440299988, -0.2740689516067505, -0.5622636079788208, -0.4185323119163513, -0.34667903184890747, 0.845181941986084, 0.29537004232406616, 0.7634463310241699, -0.19331905245780945, -0.9887905120849609, -0.06919854879379272, 0.06952069699764252, -0.5427013039588928, -0.03463410958647728, 1.267943024635315, -0.3473852276802063, -0.3800536096096039, -0.057559121400117874, 0.7785180807113647, 0.9641822576522827, 0.02458510734140873, -0.7357851266860962, 0.24909545481204987, -0.06765536218881607, 0.13029369711875916, -0.32317543029785156, -0.10800088196992874, -0.5399888753890991, 0.569368839263916, -0.310279905796051, 0.10933959484100342, 0.19152159988880157, 0.1443912833929062, 0.07827664166688919, 0.2504851222038269, 0.5528592467308044, 0.22136469185352325, -0.10673101246356964, 0.26298171281814575, -0.32300856709480286, -0.288885235786438, -0.15164506435394287, 0.03572501614689827, -0.46736741065979004, 0.14384710788726807, -5.549750804901123, 0.5651195049285889, 0.14957617223262787, -0.5636269450187683, 0.20482534170150757, 0.004564989358186722, 0.9986544847488403, 0.17148341238498688, 0.31900331377983093, -0.06473329663276672, 0.27417781949043274, 0.1268582046031952, -0.11965935677289963, 0.2608458399772644, -0.23731406033039093, -0.36552226543426514, 0.05916902795433998, -0.2861359119415283, 0.9746266007423401, 0.08114244043827057, 0.09845126420259476, -0.16309545934200287, 0.2736447751522064, 0.17920614778995514, -0.15673810243606567, 0.08693249523639679, -1.0342988967895508, 0.044817965477705, -0.2320089191198349, -0.8492238521575928, 0.21998363733291626, -0.49121206998825073, -0.05564798787236214, -0.08122240006923676, 0.0904041975736618, -0.3383425176143646, -0.21254080533981323, -0.03348776325583458, 0.1012665331363678, -0.3012508749961853, 0.3259892761707306, 0.17400304973125458, -0.09201846271753311, -0.061782751232385635, 0.22776278853416443, 0.28361010551452637, -0.18066762387752533, 0.19267065823078156, -0.18441753089427948, 0.9951249361038208, 0.17123547196388245, -0.44539690017700195, -0.004513488616794348, 0.47172075510025024, 0.33053913712501526, 0.1078571304678917, -0.18371452391147614, 0.1282985657453537, -0.5464609265327454, 0.18612195551395416, -0.4918992817401886, 0.19799666106700897, 0.17751775681972504, -0.8230297565460205, -0.19908754527568817, 0.5343492031097412, -0.8720288872718811, -0.3948039710521698, 0.8024268746376038, -0.4125518202781677, -0.34867963194847107, 0.11452564597129822, 0.26044291257858276, -0.6080290675163269, 0.4757615327835083, -0.06290709227323532, -0.051088400185108185, -0.2966451942920685, -0.11326834559440613, -0.46586254239082336, 0.01628562994301319, -0.26696157455444336, 0.2110106199979782, -0.22377818822860718, 0.2901923358440399, -0.535792350769043, -0.09919437766075134, -0.03814852982759476, -0.36366814374923706, 0.23295429348945618, 0.5534312129020691, -0.5035780668258667, -0.0992773175239563, 0.10798823833465576, 0.6665962934494019, 0.5573143362998962, 0.2716590464115143, 0.6354476809501648, 0.3992810547351837, 0.4887619614601135, 0.5655786991119385, -0.3144516348838806, -0.29479655623435974, -1.2081432342529297, 0.13492271304130554, 0.19962717592716217, -0.5870040059089661, -0.07418940961360931, 0.4648304879665375, -0.8113057017326355, 0.1455431580543518, -0.12110599875450134, -0.33138954639434814, -0.11227722465991974, 0.5539721250534058, -0.3893555998802185, -0.11111994087696075, -0.6080600619316101, 0.5173347592353821, 0.040143728256225586, 0.13108989596366882, 0.3513037860393524, -0.52608722448349, 0.3563736379146576, 0.28552985191345215, -0.5296720862388611, 0.4217534363269806, 0.8607065677642822, -0.49215155839920044, -0.22452715039253235, 0.5665275454521179, 0.3250200152397156, -0.5059049129486084, -0.8068149089813232, 0.3505094647407532, -0.2000683844089508, -0.8405702114105225, 0.6298440098762512, 0.5491205453872681, 0.37773922085762024, 0.07627589255571365, -0.4586038887500763, -0.14461961388587952, 0.2504037320613861, 0.6553252935409546, 0.1411801427602768, 0.47614309191703796, 0.25408270955085754, -0.24791733920574188, -0.25763821601867676, 0.10578688979148865, -0.1868896633386612, 0.5088890790939331, -0.2185368686914444, -0.17523527145385742, 0.30104559659957886, 0.4111507833003998, -0.06547148525714874, 0.2991117238998413, -0.5326201915740967, 0.12412996590137482, 0.28456494212150574, -0.7363144159317017, 0.5742273926734924, -0.4691183865070343, -0.4561627209186554, 0.2576887607574463, -0.776911735534668, 0.03227594494819641, 0.3389117419719696, -0.5124555826187134, -0.08314386755228043, 0.23896439373493195, -0.0874546691775322, 0.33294597268104553, 0.04975954070687294, -0.11376029253005981, 0.2762053906917572, -0.07975619286298752, 0.07573316246271133, 0.04885280877351761, -0.1841259002685547, -0.3519417941570282, 0.08513232320547104, 0.39398759603500366, 0.28133073449134827, 0.06439319252967834, -0.06890042871236801, -0.21266065537929535, -0.4214616119861603, 0.19850939512252808, 0.33423110842704773, 0.599716305732727, -0.28759515285491943, 0.06724534928798676, 0.042652275413274765, 0.502816915512085, 0.9500790238380432, 0.05652491748332977, -0.7842705249786377, 0.24948135018348694, 0.4709669351577759, -0.2738606631755829, 0.5336233377456665, 0.6351275444030762, -0.16915637254714966, -0.4689425528049469, -0.034574877470731735, 0.13526400923728943, -0.37310177087783813, -0.2513374984264374, -0.41068220138549805, -0.061342209577560425, 0.2104879766702652, -0.3337176740169525, 0.049665242433547974, 0.3227859437465668, -0.11684272438287735, -0.27805569767951965, 0.14658428728580475, -0.056737761944532394, 0.018014708533883095, 0.3005983233451843, 0.1435646265745163, -0.5372098684310913, 0.0031450262758880854, 0.7968738675117493, -0.797073483467102, 0.22658830881118774, -0.06459205597639084, -0.0520203672349453, -0.03702876716852188, 0.3106670081615448, -0.10783267766237259, -0.3925114870071411, -0.6821087002754211, -0.18916277587413788, -0.026585670188069344, -0.03281302750110626, 0.6363028287887573, 0.05356062948703766, 0.6139299273490906, -0.4054456949234009, -0.25629276037216187, -0.5637016296386719, 0.37011295557022095, 0.3074776232242584, -0.4292575716972351, -0.4976101219654083, 0.10299010574817657, 0.7153684496879578, -0.22489050030708313, 0.15574613213539124, 0.2291053980588913, 1.255867600440979, -0.052509259432554245, -0.28054261207580566, -0.2616840898990631, -0.35009947419166565, -0.005487202666699886, -0.34468701481819153, -0.2648349702358246, -0.2680467963218689, -0.14151479303836823, 0.27105093002319336, -0.10327316075563431, 0.3674643635749817, -0.7814022898674011, 0.24765121936798096, -0.3362027108669281, -0.24027785658836365, -0.3601846694946289, 0.7551258206367493, 0.4100556969642639, -0.2785812318325043, 0.2808614671230316, -0.560001790523529, -0.006020653061568737, -0.012107624672353268, 0.15771690011024475, -0.44280996918678284, -0.4055146276950836, 0.4748423993587494, -0.5823550820350647, 0.3341146409511566, -0.8264887928962708, 0.24974171817302704, -0.3934599459171295, -0.04677935317158699, -0.5980162024497986, -0.20399843156337738, 0.006415846291929483, -0.8123952746391296, -0.5606930255889893, -0.3986654579639435, -0.03353242948651314, -0.1593903750181198, 0.2327020913362503, 0.21863225102424622, -0.36854231357574463, -0.7158978581428528, -0.07506113499403, 0.5371886491775513, -0.30682167410850525, -0.01013870071619749, -0.10376238077878952, 0.05087331309914589, 0.15569953620433807, -0.6368765830993652, 0.002656476106494665, -0.15315379202365875, 0.04058336466550827, 0.5314673185348511, -0.06242003291845322, -0.3824229836463928, -0.06262132525444031, -0.6803603172302246, -0.3742113709449768, 0.6040344834327698, 0.08604405075311661, 0.37848803400993347, 0.9417328834533691, 0.521070659160614, 0.26749658584594727, -0.2762925922870636, 0.881399929523468, 0.1548192799091339, 0.3197169601917267, 0.2706446945667267, -0.10371221601963043, -0.09251876920461655, 0.02215554751455784, -0.039553023874759674, 0.66475510597229, 0.3484153151512146, 0.33892661333084106, 0.3669491112232208, -0.4037686884403229, -0.4300978183746338, 0.15146207809448242, 0.7490376234054565, 0.4167042672634125, -0.11809197813272476, -0.23781360685825348, 0.5447591543197632, 0.23283953964710236, 0.1801321655511856, 0.26756179332733154, 0.012865539640188217, 0.1122281402349472, 0.02601148560643196, -0.7813377976417542, -0.6471693515777588, -0.013774318620562553, -0.5717470645904541, 0.04577169194817543, 0.284915030002594, -0.4877376854419708, -0.9521567821502686, -0.13754341006278992, -0.608757495880127, -0.160064697265625, -0.5036129355430603, 0.749031662940979, -0.21952205896377563, -0.29925093054771423, 0.043842412531375885, 0.2476847767829895, 0.4132218360900879, -0.46046802401542664, 0.0985584631562233, -0.25951245427131653, 0.010248086415231228, 0.5525036454200745, 0.23990164697170258, -0.7191917300224304, 0.053627196699380875, -0.21467870473861694, -0.40496203303337097, 0.49143651127815247, -0.1804048866033554, 0.28807005286216736, 0.263958215713501, -0.6142902970314026, -0.3474560081958771, -0.23264597356319427, -0.32460635900497437, -0.24140870571136475, 0.18513566255569458, -0.2890722155570984, 0.49472305178642273, -0.37894466519355774, 0.08467870205640793, 0.45887893438339233, -0.2883615493774414, -0.0777316465973854, 0.017734389752149582, 0.1765390932559967, 0.13942186534404755, 0.7718254327774048, 0.47416454553604126, 0.49011489748954773, 0.18356455862522125, 1.0656968355178833, -0.7193576693534851, 0.25659269094467163, -0.23719003796577454, -0.24023732542991638, -0.8891802430152893, -0.1673176884651184, 0.8923818469047546, 0.9791044592857361, -0.10942095518112183, -0.04052664712071419, 0.6137511134147644, 0.019424278289079666, 0.2163337767124176, -0.360507071018219, -0.20797698199748993, -0.2461078017950058, -0.010464800521731377, -0.8065022826194763, 0.6775251626968384, -0.2657019793987274, -0.5834530591964722, -0.48916420340538025, 0.41047313809394836, 0.3498345911502838, 0.12147785723209381, 0.31505995988845825, -0.4714359641075134, -0.29034170508384705, -0.7059906721115112, 0.6224271059036255, -0.41676846146583557, 0.9104151129722595, -0.4803352952003479, 0.3540703356266022, 0.24418167769908905, -0.25689348578453064, -0.14507588744163513, -0.21856148540973663, 0.3300149738788605, -0.1895074099302292, -0.11626505851745605, 0.23503361642360687, 0.5334752202033997, -0.47020629048347473, -0.8450207114219666, 0.13015733659267426, 0.010653558187186718, -0.7011709213256836, -0.171078160405159, 0.32044506072998047, 0.060402944684028625, -0.20707392692565918, -0.026298662647604942, -0.28157585859298706, -0.32047149538993835, -0.059441156685352325 ]
The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to decipher the oncogenic regulatory circuit controlled by TLX1 and TLX3. This systems biology analysis defined T cell leukemia homeobox 1 (TLX1) and TLX3 as master regulators of an oncogenic transcriptional circuit governing T-ALL. Notably, a network structure analysis of this hierarchical network identified RUNX1 as a key mediator of the T-ALL induced by TLX1 and TLX3 and predicted a tumor-suppressor role for RUNX1 in T cell transformation. Consistent with these results, we identified recurrent somatic loss-of-function mutations in RUNX1 in human T-ALL. Overall, these results place TLX1 and TLX3 at the top of an oncogenic transcriptional network controlling leukemia development, show the power of network analyses to identify key elements in the regulatory circuits governing human cancer and identify RUNX1 as a tumor-suppressor gene in T-ALL.
[ 0.004431299865245819, 0.010799212381243706, -0.02019721269607544, -0.00014239223673939705, 0.007153137121349573, -0.0074345944449305534, 0.012970514595508575, -0.0032854625023901463, -0.015022693201899529, -0.012612883001565933, -0.016980938613414764, 0.0035853551235049963, -0.012035226449370384, 0.015323569998145103, 0.0030920833814889193, 0.014674854464828968, -0.014888877980411053, -0.005923408083617687, 0.022895222529768944, 0.0076211243867874146, -0.00519733689725399, -0.002415028400719166, 0.00985525082796812, 0.030458305031061172, 0.011232266202569008, 0.00014123041182756424, 0.0005327709950506687, 0.035796307027339935, -0.004390827380120754, -0.0029193595983088017, 0.014322063885629177, 0.004219821188598871, 0.02714601904153824, 0.006092272698879242, -0.010075170546770096, -0.014047414064407349, -0.005067250691354275, 0.020084116607904434, 0.03498070687055588, -0.006071747280657291, 0.0034862258471548557, -0.015860293060541153, 0.0012893244856968522, -0.004053766839206219, -0.007691492792218924, 0.007000754587352276, -0.005068432539701462, 0.01172579824924469, 0.002017687074840069, 0.005862081423401833, -0.025023967027664185, -0.015562228858470917, -0.012278208509087563, 0.0378628708422184, -0.006990584544837475, -0.011073125526309013, 0.018642501905560493, -0.011811085045337677, 0.02866215445101261, 0.04699098318815231, -0.0037797652184963226, -0.0026668477803468704, -0.005622172728180885, -0.0036319077480584383, 0.01047767885029316, -0.06652291864156723, 0.012388009577989578, 0.024359654635190964, 0.00017719564493745565, 0.008381295949220657, 0.011979283764958382, 0.006982047110795975, 0.006886664777994156, -0.05283424258232117, -0.020464852452278137, -0.013389850966632366, -0.013234325684607029, 0.0017438111826777458, 0.01830754429101944, 0.028448496013879776, -0.000007191672921180725, 0.017912831157445908, -0.0023518044035881758, 0.009815039113163948, -0.021616065874695778, -0.012937881052494049, 0.008412566967308521, -0.00285642989911139, -0.012448269873857498, -0.0015058442950248718, 0.0032080444507300854, -0.0061124153435230255, 0.0028600096702575684, -0.006524648517370224, -0.05466247722506523, -0.025315023958683014, -0.01718549244105816, -0.023492764681577682, 0.012096814811229706, 0.002051461488008499, -0.005190311931073666, 0.03273157775402069, 0.01906721480190754, 0.0105830617249012, -0.0042606545612216, 0.008176987059414387, 0.00186527194455266, -0.015575787052512169, -0.007933955639600754, 0.009877341799438, -0.014896433800458908, 0.005555956624448299, -0.0048050228506326675, 0.004201828967779875, 0.015044032596051693, 0.01704411953687668, -0.01827697828412056, -0.0017086314037442207, 0.010248640552163124, -0.015336625277996063, -0.005482698790729046, -0.006218869239091873, -0.008167478255927563, -0.004152555949985981, 0.004582680761814117, -0.013218533247709274, -0.010003773495554924, 0.0029691681265830994, 0.017299799248576164, 0.010688873007893562, -0.0094438586384058, -0.0008608370553702116, -0.025278009474277496, -0.031231185421347618, -0.012709175236523151, 0.004593142308294773, -0.029309110715985298, 0.03274057060480118, -0.004869939759373665, -0.007911166176199913, -0.022260790690779686, 0.002504608128219843, 0.009461451321840286, 0.00999781209975481, 0.025368288159370422, -0.001346561941318214, -0.03883690759539604, -0.0007246960885822773, 0.018478315323591232, -0.03613416850566864, 0.005136982072144747, -0.01405472494661808, 0.005877193994820118, -0.018592743203043938, 0.028439443558454514, 0.04004727676510811, -0.02065548300743103, -0.04997805878520012, -0.010987447574734688, 0.006041466258466244, 0.008805140852928162, -0.009953770786523819, 0.03106583282351494, 0.00915911328047514, 0.03452107310295105, -0.002208903431892395, 0.017212629318237305, -0.013417733833193779, -0.0046493662521243095, 0.0058234939351677895, -0.0052858274430036545, -0.0010908008553087711, 0.00004224199801683426, 0.008969424292445183, -0.031261738389730453, -0.0034397365525364876, 0.005507292691618204, 0.007768622133880854, -0.010588780976831913, 0.06681764125823975, -0.0009004026651382446, 0.00935187004506588, 0.010667138732969761, 0.0010151364840567112, 0.011615901254117489, 0.0013878298923373222, 0.014457069337368011, 0.0028436584398150444, -0.014186084270477295, 0.012200572527945042, 0.024554351344704628, -0.001916701439768076, -0.03135104477405548, 0.010297738015651703, -0.03954526409506798, 0.002756543457508087, -0.010114847682416439, 0.002992744091898203, 0.015775403007864952, 0.017580900341272354, 0.008309559896588326, -0.021345149725675583, 0.015786143019795418, -0.027161989361047745, -0.00043455371633172035, 0.004201880656182766, -0.006159660872071981, -0.03802601993083954, 0.013880746439099312, 0.015285812318325043, 0.02419879287481308, 0.0018380149267613888, 0.004148670472204685, -0.010917797684669495, -0.0005759226623922586, 0.008870096877217293, -0.0016959658823907375, 0.020435968413949013, 0.03725362569093704, -0.01440698653459549, 0.00024111231323331594, 0.004968574736267328, 0.009019384160637856, -0.034731537103652954, 0.030876170843839645, -0.01406579278409481, -0.0004557538777589798, 0.012153849937021732, -0.01812063343822956, 0.0012964056804776192, 0.010956346988677979, -0.01377510279417038, -0.013684481382369995, 0.03092389926314354, -0.02395111694931984, -0.008527129888534546, 0.01156037487089634, -0.01993018016219139, 0.012286880984902382, -0.0067709097638726234, -0.014499659650027752, -0.0023249820806086063, 0.027394406497478485, -0.01833578571677208, -0.004332649987190962, -0.000906563363969326, 0.03618599474430084, 0.01946886256337166, 0.0037804909516125917, -0.011934283189475536, 0.0109992865473032, -0.0017853844910860062, -0.006555122323334217, -0.0002160598523914814, 0.0013499544002115726, 0.021166596561670303, -0.018281474709510803, -0.029327360913157463, 0.02710297331213951, -0.011296713724732399, -0.005308164749294519, 0.0026690843515098095, -0.007486238144338131, -0.027160057798027992, 0.007880808785557747, -0.013786090537905693, 0.03322068229317665, 0.023140553385019302, 0.029139380902051926, 0.0012264633551239967, 0.009922889992594719, -0.0025948542170226574, 0.0062993173487484455, -0.08151155710220337, -0.0124724255874753, 0.00805688090622425, 0.01853001117706299, 0.011531095951795578, -0.022944997996091843, -0.0052362182177603245, 0.015179738402366638, -0.004698906093835831, -0.003826832165941596, -0.01105185691267252, 0.005043385084718466, -0.015688249841332436, -0.03891602158546448, -0.001104156719520688, -0.017790522426366806, 0.014649483375251293, -0.015294955112040043, -0.0014687955845147371, -0.021993834525346756, 0.0016240151599049568, -0.014957237988710403, 0.02199881710112095, -0.002543307840824127, -0.021811384707689285, 0.0123214740306139, -0.0022411514073610306, -0.014252332039177418, -0.017939096316695213, 0.006024094298481941, -0.043806590139865875, -0.0001607104204595089, 0.007960120216012001, 0.01414458081126213, -0.005366046912968159, -0.006027194205671549, 0.007561069447547197, -0.004784373566508293, -0.01420014537870884, 0.04495129734277725, -0.01407494954764843, 0.020831499248743057, -0.01991960033774376, 0.006324398331344128, 0.00937594659626484, 0.008933904580771923, -0.02796606905758381, 0.016376378014683723, 0.02342047169804573, 0.025236617773771286, -0.014189943671226501, 0.008394191041588783, 0.007178885862231255, 0.01002310961484909, -0.016047347337007523, -0.020157013088464737, -0.011414320208132267, 0.007314586546272039, -0.007511523086577654, -0.013509823009371758, 0.03932008519768715, -0.0003742314875125885, 0.01778670772910118, -0.002785125747323036, 0.02779172733426094, 0.013739206828176975, 0.019725576043128967, -0.018994124606251717, -0.019818704575300217, 0.017606869339942932, -0.0037263482809066772, -0.0199982188642025, -0.03289305046200752, -0.00973724015057087, -0.011168429628014565, -0.011860508471727371, -0.012465495616197586, -0.003782175714150071, 0.009023230522871017, -0.009620650671422482, -0.016997605562210083, -0.014045074582099915, -0.014648769982159138, -0.010477546602487564, -0.010139822028577328, -0.0445607453584671, 0.011655552312731743, 0.034260090440511703, 0.012570718303322792, -0.018682444468140602, 0.011264474131166935, 0.02848724089562893, -0.024419214576482773, 0.013679086230695248, 0.011129695922136307, -0.015668556094169617, -0.01077860314399004, -0.008286131545901299, 0.02159930393099785, 0.01029975339770317, -0.03302520513534546, 0.003053433494642377, 0.006363931577652693, -0.006589531898498535, 0.0018636209424585104, 0.011454715393483639, 0.0021500808652490377, -0.0064659095369279385, -0.027722787111997604, 0.0013594543561339378, 0.005094640888273716, 0.02349686808884144, -0.009013624861836433, 0.03022545389831066, 0.007983751595020294, 0.019248701632022858, -0.003191937692463398, -0.006181388162076473, 0.07151470333337784, -0.011920453049242496, 0.0034506286028772593, -0.021477045491337776, -0.011347523890435696, -0.014939472079277039, -0.0012199818156659603, -0.022458266466856003, -0.018603887408971786, -0.01396040990948677, 0.014840679243206978, -0.007660274859517813, -0.0020021020900458097, 0.005129246041178703, 0.009825595654547215, 0.001908344915136695, -0.020724469795823097, 0.010486718267202377, 0.045507192611694336, -0.0031146295368671417, 0.005578966811299324, -0.02193545550107956, -0.003958904650062323, 0.0051805865950882435, 0.003945220727473497, -0.01841113343834877, -0.01168486475944519, -0.014805834740400314, -0.014670692384243011, 0.011565477587282658, 0.03112223371863365, -0.045835044234991074, -0.008266342803835869, -0.015058699995279312, 0.009602093137800694, -0.015108350664377213, 0.02262287028133869, -0.0070200106129050255, 0.017953503876924515, -0.004075073637068272, -0.029193587601184845, -0.01735597476363182, -0.00882924534380436, 0.00945696234703064, 0.0032712239772081375, 0.004523613024502993, -0.0002566734328866005, -0.003840422723442316, -0.01046726107597351, 0.0025099599733948708, -0.010291047394275665, 0.0008711616974323988, 0.013604437001049519, 0.03138727322220802, -0.012229599058628082, -0.003001113887876272, 0.000857232604175806, -0.011153176426887512, -0.00467875087633729, -0.019860979169607162, 0.01679052785038948, 0.005634436849504709, 0.021717283874750137, -0.008200193755328655, 0.02177148126065731, -0.027635160833597183, -0.0041646151803433895, 0.0016180477105081081, -0.02446717582643032, -0.043562524020671844, 0.02168683335185051, 0.00344840413890779, -0.021469950675964355, -0.011100937612354755, -0.028814654797315598, 0.020036324858665466, -0.006751527078449726, -0.015793785452842712, 0.007427502423524857, 0.004149227403104305, -0.014671040698885918, 0.016981804743409157, 0.030761592090129852, 0.007829149253666401, 0.01018882542848587, 0.008039971813559532, -0.0020720399916172028, -0.07480143010616302, -0.006227672100067139, 0.01425038743764162, -0.007133438717573881, 0.016763053834438324, -0.01833764836192131, -0.006941251922398806, 0.010025590658187866, 0.01346831489354372, -0.008677241392433643, -0.041992634534835815, 0.012064187787473202, 0.007018182426691055, 0.024827852845191956, 0.011662391945719719, 0.008732447400689125, -0.011674409732222557, 0.004658794496208429, -0.006308475974947214, 0.027818262577056885, 0.011552521958947182, -0.0008075553923845291, -0.021679457277059555, 0.0033867524471133947, 0.013909624889492989, -0.0801667720079422, -0.010097594931721687, -0.01970204897224903, -0.014006111770868301, 0.011976117268204689, -0.03444082289934158, 0.004916459321975708, -0.018196670338511467, -0.007085166405886412, -0.015335777774453163, -0.030400805175304413, 0.009649492800235748, -0.01841706410050392, -0.0246314387768507, 0.008418041281402111, -0.004508029203861952, 0.014316503889858723, -0.008512691594660282, 0.0010518825147300959, 0.006675927899777889, 0.004323108121752739, -0.011150282807648182, -0.013379262760281563, -0.003456298727542162, -0.009257514029741287, -0.012388202361762524, -0.012443721294403076, 0.018279820680618286, 0.007209892384707928, 0.0005711927078664303, 0.0165419764816761, -0.02552037686109543, -0.005671130493283272, -0.013980384916067123, -0.007571847178041935, -0.01720517687499523, 0.0018142659682780504, -0.0061535960994660854, -0.02854197472333908, 0.014501648023724556, -0.004023961257189512, -0.001714310608804226, -0.010265687480568886, 0.012907507829368114, -0.015830261632800102, -0.019334452226758003, 0.00753625575453043, -0.0034285234287381172, 0.007224338594824076, 0.008291749283671379, 0.008207871578633785, 0.002509984653443098, -0.011201592162251472, 0.01621284708380699, -0.007000486832112074, 0.013288602232933044, -0.0001374254352413118, -0.010931648313999176, 0.008060612715780735, 0.014739256352186203, -0.012449667789041996, 0.016097061336040497, -0.009241733700037003, 0.07173416018486023, -0.013857029378414154, 0.011925999075174332, -0.04558749124407768, -0.0003717920044437051, 0.0017329888651147485, 0.011307571083307266, -0.0005650501698255539, -0.040702931582927704, -0.020881831645965576, 0.004192214459180832, -0.01570291258394718, 0.01487988606095314, 0.014077765867114067, 0.020928099751472473, 0.005825834348797798, 0.03435864672064781, 0.011084641329944134, -0.0037646214477717876, 0.008481936529278755, -0.004266155883669853, -0.00504434434697032, -0.006959623657166958, -0.019707120954990387, -0.0030419728718698025, 0.0041919611394405365, -0.04614732414484024, -0.008024301379919052, -0.03676699846982956, 0.0107773058116436, -0.01810324564576149, 0.001389998011291027, -0.004255139268934727, -0.015164576470851898, 0.030259907245635986, -0.016256242990493774, -0.02578740566968918, 0.019101068377494812, -0.010399655438959599, 0.00399533286690712, 0.0008346517570316792, 0.013325425796210766, -0.010319925844669342, -0.0028911707922816277, -0.010637244209647179, -0.03156259283423424, -0.009750708937644958, -0.01746845245361328, 0.0008397530764341354, 0.007730809971690178, 0.04950091987848282, 0.0003352910280227661, 0.006043830420821905, -0.016754280775785446, 0.009139101020991802, 0.022318527102470398, -0.009057664312422276, 0.01787574589252472, -0.03984888270497322, -0.004781403578817844, 0.0036033191718161106, -0.01822015643119812, 0.009397122077643871, -0.008486445993185043, -0.0019921958446502686, -0.02872164361178875, -0.0016035772860050201, -0.029208261519670486, 0.007568018510937691, 0.016733650118112564, 0.035479817539453506, 0.005487149581313133, 0.01006078626960516, 0.011462686583399773, 0.04525318741798401, 0.023225411772727966, -0.012946676462888718, -0.0037286323495209217, 0.01996440440416336, 0.012131703086197376, -0.004322567954659462, 0.040496766567230225, -0.006536764092743397, 0.00624499749392271, -0.010103888809680939, -0.007305542938411236, -0.003103062277659774, -0.011682762764394283, 0.001288009574636817, 0.01319983322173357, 0.03594508022069931, 0.003160198451951146, 0.009184226393699646, -0.01217009499669075, 0.004091177135705948, 0.03581668436527252, 0.017038777470588684, 0.009563702158629894, -0.0005171420052647591, 0.0012659835629165173, -0.01703738234937191, 0.02664707414805889, 0.011911587789654732, 0.0027241529896855354, -0.021472489461302757, -0.004578704014420509, -0.04047264903783798, -0.029952358454465866, -0.007834112271666527, 0.025826362892985344, -0.0066826315596699715, -0.03277372568845749, 0.021573854610323906, -0.03990333899855614, 0.008492588996887207, 0.006801028735935688, 0.010852107778191566, 0.0027361102402210236, -0.015245584771037102, -0.012885930016636848, -0.0004511140286922455, 0.008983500301837921, -0.01067951787263155, 0.043919727206230164, -0.0013382346369326115, -0.0028929966501891613, -0.01365891844034195, 0.010634975507855415, -0.018811069428920746, -0.0246425848454237, 0.020418936386704445, -0.0012537501752376556, -0.004287092015147209, -0.003987658303231001, 0.014044361189007759, 0.017975524067878723, -0.0073110926896333694, 0.019206028431653976, -0.0073132747784256935, 0.022325623780488968, -0.002223819959908724, -0.015038257464766502, -0.0049071768298745155, 0.004261749796569347, 0.008680317550897598, -0.016745243221521378, 0.007343984209001064, 0.016590287908911705, -0.00001777650322765112, -0.008027061820030212, 0.0180068202316761, 0.013574952259659767, 0.007035634480416775, -0.009502004832029343, 0.02187502011656761, 0.019948553293943405, 0.012578076682984829, -0.007134947460144758, -0.018619058653712273, -0.03286164253950119, -0.0024954904802143574, 0.005186588037759066, -0.032560598105192184, 0.003151265438646078, 0.023922501131892204, -0.013983886688947678, -0.00627982709556818, 0.02365989051759243, -0.0006639750208705664, -0.005890901666134596, -0.0005571015644818544, -0.017682749778032303, 0.015006301924586296, 0.014641709625720978, -0.020286813378334045, -0.003614393062889576, -0.01327626034617424, -0.01114297192543745, 0.007107530254870653, -0.009290697984397411, 0.016596084460616112, -0.019825899973511696, -0.01898615062236786, -0.005350614432245493, -0.01404827181249857, -0.0038212963845580816, 0.007986553013324738, -0.015817683190107346, -0.00901499018073082, -0.013222279958426952, -0.019551562145352364, -0.010978342965245247, -0.0005737489555031061, 0.029259460046887398, -0.00924551859498024, -0.0036606313660740852, 0.030012160539627075, 0.006291919853538275, 0.010200617834925652, -0.0065496196039021015, 0.006363553460687399, -0.01658784970641136 ]
[ 0.2751491367816925, -0.23583917319774628, -0.17656630277633667, 0.12639206647872925, -0.09437796473503113, -0.16360679268836975, 0.1558983474969864, 0.02106194756925106, -0.25730380415916443, -0.41885578632354736, 0.10506556183099747, 0.2452647089958191, -0.598281741142273, 0.2959457337856293, 0.004382809158414602, 0.5481340885162354, 0.06528337299823761, 0.4127698242664337, -0.1109505295753479, -0.6508312225341797, -0.07482217997312546, -0.6654027104377747, 0.469708114862442, -0.23688703775405884, 0.12040327489376068, 0.14386704564094543, 0.34943312406539917, -0.10199247300624847, 0.5701679587364197, 0.007587880827486515, 0.2853491008281708, 0.41683799028396606, 0.16074015200138092, -0.032833706587553024, -0.5835330486297607, -0.08721960335969925, -0.23569095134735107, 0.07061420381069183, 0.13055358827114105, -0.19769597053527832, 0.019741270691156387, -0.4552326202392578, -0.470323771238327, 0.4219628870487213, -0.13491187989711761, -0.05078308284282684, -1.4636566638946533, 0.594598114490509, -0.4026959240436554, -0.015807118266820908, -0.19338972866535187, 0.17996610701084137, -0.0682343915104866, 0.26692521572113037, 0.41440436244010925, 0.3075673580169678, -0.6852419972419739, 0.009796557016670704, 0.21460407972335815, -0.4395750164985657, -0.041021090000867844, -0.15618140995502472, -0.14200229942798615, 0.2334863394498825, 0.09033862501382828, 0.7559596300125122, -0.019363241270184517, -0.39247751235961914, -0.8866691589355469, -0.35611146688461304, 0.26846638321876526, -0.4254615008831024, -0.024085061624646187, 0.42516422271728516, 0.3557271659374237, 0.016970088705420494, -0.6577171683311462, -0.5787813067436218, 0.41144219040870667, 0.12580859661102295, -0.22746488451957703, 0.08619789034128189, 0.503002405166626, 0.11692081391811371, 0.30351483821868896, 0.5062799453735352, 0.28765636682510376, 0.43345561623573303, -0.7228888869285583, 0.049066562205553055, -0.26019445061683655, -0.037141088396310806, 0.44603481888771057, 0.20981121063232422, 0.32331517338752747, 0.5186801552772522, -0.011380894109606743, 0.35465413331985474, -0.15436816215515137, 0.021409565582871437, -0.10128746926784515, 0.022578738629817963, -0.15888962149620056, -0.6924107074737549, -0.8830606341362, -0.5812228322029114, -0.012995635159313679, -0.6416182518005371, -0.46013644337654114, -0.14195844531059265, -0.5840858221054077, 0.11552054435014725, -0.3423645496368408, -0.189104363322258, -0.019430620595812798, 0.4395633339881897, 0.1841598004102707, -0.6733468174934387, 0.5702099204063416, 0.23655195534229279, -0.1646636575460434, 1.0911811590194702, -0.30867505073547363, 0.5917592644691467, 0.16039922833442688, 0.0255380067974329, -0.1442856341600418, -0.08234316855669022, 0.18571992218494415, 0.22005580365657806, 0.17159859836101532, 1.0665700435638428, -0.3297102451324463, -0.04379744827747345, 0.15319296717643738, -0.21009944379329681, 0.32925981283187866, -0.000887047266587615, 0.16015984117984772, 0.055678460747003555, -0.7725010514259338, -0.3645411729812622, -0.28900331258773804, -0.36220940947532654, -0.07895880937576294, -0.44851863384246826, -0.5728003978729248, 0.1861860156059265, 0.20222674310207367, -0.32788896560668945, -0.10973583906888962, -0.7184662222862244, -0.37464919686317444, 0.04470837116241455, -0.10329049080610275, 0.5007393956184387, 0.3599983751773834, -0.10921665281057358, 0.27913036942481995, 0.3706953823566437, -0.04559292271733284, -0.21310696005821228, -0.32408037781715393, 0.0347149483859539, 0.5195386409759521, -0.08127904683351517, 0.21624384820461273, 0.17183655500411987, -0.4051072597503662, -0.43206271529197693, -0.5423476099967957, -0.5577039122581482, -0.08587837964296341, -0.45229095220565796, -0.2333708107471466, -0.4326038658618927, -0.0637475848197937, -0.06333102285861969, 0.14200487732887268, -0.07508830726146698, -0.9467702507972717, -0.05350871756672859, -0.05035755783319473, -0.4514131546020508, 0.6154788136482239, 0.38631194829940796, 0.5789536237716675, -0.07228279113769531, -0.23741218447685242, 0.2651278078556061, -0.041409045457839966, -0.061054542660713196, 0.6883010268211365, -0.6279144883155823, 1.2596200704574585, -0.3449705243110657, -0.500935435295105, 1.2636724710464478, 0.13914723694324493, 0.29751092195510864, -0.2086995542049408, -0.4281756579875946, 0.5770468711853027, -0.48913636803627014, -0.37245482206344604, 0.07769495993852615, -0.19222649931907654, -0.2564890682697296, -0.05699799209833145, -0.06752289831638336, 0.3692827522754669, -0.37228795886039734, -0.22104357182979584, 0.1259855180978775, 0.28127655386924744, -0.5751209855079651, 0.17554312944412231, -0.2603188455104828, -0.4672638475894928, -0.14083059132099152, 0.5298972725868225, -0.9521066546440125, 0.348001092672348, 1.0422911643981934, -0.2470007687807083, 0.5849258899688721, 0.32431885600090027, 0.18900704383850098, 0.8851059079170227, -0.03227107599377632, 0.3622412085533142, -0.3864695131778717, 0.3085521161556244, -0.2969115674495697, -0.023186108097434044, 0.33488842844963074, -0.06146229803562164, -0.012160045094788074, 0.016792476177215576, -0.01974375918507576, 0.082413449883461, 0.9254775643348694, -0.6734362244606018, -0.17872373759746552, -0.007579556666314602, -0.5784962773323059, -0.27022722363471985, 0.27372631430625916, -0.997568666934967, -0.24794763326644897, 0.1761537492275238, 0.11177466064691544, 0.24741852283477783, -0.5019021034240723, 0.05426571145653725, 0.44271594285964966, -0.19525477290153503, -0.0176897794008255, -0.15695109963417053, -0.33161959052085876, -0.18421880900859833, -0.22577925026416779, -0.17555248737335205, 0.18126362562179565, -0.004832220729440451, -0.6195191144943237, -0.7719976305961609, 0.05691464617848396, 0.9867698550224304, 0.7887964248657227, 1.110491156578064, -0.3080742657184601, -0.5758004784584045, -0.30915960669517517, 0.23779486119747162, -0.7889614105224609, -0.10584762692451477, 0.5099884867668152, -0.448480486869812, -0.2868010699748993, 0.029958298429846764, 0.11536037921905518, 1.1241750717163086, -0.23004058003425598, -0.6444904804229736, -0.009987534023821354, 0.14820295572280884, -0.1911335438489914, -0.3969568610191345, -0.4155110716819763, 0.15940038859844208, 0.27146485447883606, -0.3216218054294586, -0.2001335173845291, 0.22890467941761017, 0.04356700927019119, -0.11743005365133286, 0.420785516500473, 0.4791325032711029, 0.21560513973236084, -0.4337635636329651, 0.618549108505249, -0.46188196539878845, -0.5905964374542236, 0.23221679031848907, 0.09808796644210815, -0.43539586663246155, 0.316421777009964, -5.91370153427124, -0.14422130584716797, 0.007729608565568924, -0.3648880124092102, -0.08345551788806915, -0.4056152403354645, 0.9573916792869568, -0.008903700858354568, 0.08863469958305359, 0.2648051381111145, 0.44168367981910706, 0.20990224182605743, 0.055851247161626816, -0.3353123366832733, 0.031374912708997726, 0.008652289398014545, -0.21406269073486328, -0.14837267994880676, 0.7719863653182983, 0.12553541362285614, 0.30932047963142395, -0.2428925484418869, -0.07637596130371094, 0.18612676858901978, 0.06383702903985977, 0.40290820598602295, -1.1293714046478271, -0.060819413512945175, -0.11506692320108414, -0.4038655459880829, 0.0006483322358690202, -0.010396751575171947, -0.19397905468940735, -0.18292193114757538, 0.3062470853328705, -0.47328490018844604, 0.22258689999580383, 0.14745226502418518, 0.030115526169538498, -0.38591256737709045, 0.5998868346214294, 0.3019016683101654, -0.023901168256998062, -0.4449400305747986, -0.18696686625480652, -0.21127955615520477, -0.2811318039894104, 0.1806749403476715, -0.45739415287971497, 0.5968562364578247, -0.0904887467622757, -0.33791783452033997, 0.12819665670394897, 0.5381352305412292, 0.4756775200366974, 0.06227242201566696, -0.3280768096446991, 0.09115201979875565, -0.4703860878944397, 0.256708025932312, -0.2612713873386383, -0.3818715512752533, 0.06080399453639984, -1.0409820079803467, 0.21197177469730377, 0.18416927754878998, -0.4792160987854004, -0.24044974148273468, 0.3982129991054535, -0.14006376266479492, -0.007284457329660654, 0.1632041186094284, 0.27726027369499207, -0.8288112878799438, 0.5928283333778381, -0.3845732510089874, -0.0621681809425354, 0.12225817143917084, 0.030063843354582787, -0.36726823449134827, -0.2930607795715332, -0.2394191175699234, -0.07311004400253296, -0.07655636221170425, 0.41078120470046997, -0.41780170798301697, -0.24890440702438354, 0.0897076204419136, -0.09242256730794907, 0.6333644390106201, 0.11333535611629486, -0.284209668636322, 0.26556169986724854, 0.5014968514442444, -0.01815512403845787, 0.3047698438167572, 0.44159942865371704, 0.5963535308837891, 0.2958795726299286, -0.044290825724601746, 0.5697484016418457, -0.3239343464374542, -0.34383630752563477, -0.4424617290496826, 0.06251824647188187, 0.33757156133651733, 0.0767928808927536, 0.3780951201915741, 0.6699703335762024, -0.5980657935142517, 0.2206740826368332, -0.181741863489151, -0.41684696078300476, -0.2892392575740814, 0.3989028036594391, -0.45144858956336975, -0.332387238740921, 0.15695849061012268, 0.6799928545951843, -0.29822880029678345, 0.06437505036592484, 0.5806978344917297, -0.5897817611694336, 0.37713930010795593, 0.13911309838294983, -0.019835185259580612, -0.12206818908452988, 0.5951257944107056, -0.552660346031189, -0.057905226945877075, -0.04186629503965378, -0.012965720146894455, -0.15239612758159637, -0.24703188240528107, 0.00467041926458478, -0.3050602674484253, -0.6893219947814941, 0.31427618861198425, 0.29583942890167236, -0.06722721457481384, 0.16691963374614716, 0.0606188103556633, 0.014278038404881954, 0.07950952649116516, 0.26775723695755005, 0.22807195782661438, 0.011434435844421387, -0.06725739687681198, -0.3858446180820465, -0.5985585451126099, 0.3722507357597351, -0.684076189994812, 0.2945595979690552, -0.11447416245937347, 0.013638216070830822, 0.3179749846458435, 0.6172022819519043, 0.5259673595428467, 0.20546585321426392, -0.700678288936615, 0.25229305028915405, 0.24240483343601227, -0.9303545355796814, 0.4903925657272339, 0.16492795944213867, -0.14714236557483673, 0.2443651705980301, -0.38122522830963135, -0.3443315923213959, 0.23059651255607605, -0.41080307960510254, -0.39487916231155396, 0.1564035564661026, 0.11457090079784393, -0.11761822551488876, -0.31304433941841125, -0.14024578034877777, -0.11955317109823227, 0.3081376254558563, 0.4220118820667267, 0.08637914061546326, -0.2030741274356842, 0.019844086840748787, 0.47849902510643005, 0.295671284198761, 0.37645187973976135, -0.08673332631587982, -0.04191067814826965, -0.21972523629665375, -0.09730911999940872, 0.36284708976745605, 0.21974560618400574, 0.40815600752830505, 0.055649664252996445, 0.035374004393815994, -0.12116915732622147, -0.10943781584501266, 0.20241600275039673, 0.5256436467170715, -0.9829567670822144, 0.13267028331756592, 0.7606839537620544, 0.026875289157032967, 0.23427903652191162, 0.485537588596344, 0.07084771245718002, -0.13742658495903015, 0.11877793818712234, 0.027496175840497017, 0.07605814188718796, -0.04349644109606743, -0.690159261226654, 0.5811879634857178, 0.2510417401790619, 0.10050328075885773, -0.4607444107532501, 0.603252112865448, -0.34626948833465576, -0.25036993622779846, 0.45368582010269165, 0.386119544506073, 0.06144716218113899, -0.12758423388004303, -0.06731612980365753, -0.5488947629928589, 0.38099995255470276, 0.4565693438053131, -0.5249342918395996, 0.5553768277168274, 0.3024663031101227, 0.21915513277053833, -0.06425899267196655, 0.20558586716651917, -0.0008509763283655047, -0.3351948857307434, -0.6807488799095154, -0.1324763298034668, 0.29464951157569885, 0.2925877869129181, -0.16360515356063843, 0.45879530906677246, 0.34211859107017517, -0.46879908442497253, -0.311599999666214, 0.15926027297973633, 0.1448064148426056, 0.34952276945114136, -0.6124104857444763, -0.0853959172964096, -0.06997093558311462, 0.27402496337890625, -0.21274985373020172, 0.2439873367547989, 0.3841126561164856, 1.2788995504379272, 0.47614139318466187, -0.25457271933555603, -0.1606363207101822, -0.33882054686546326, 0.18934158980846405, -0.3137860596179962, 0.4479024112224579, -0.2277172952890396, 0.08417659997940063, 0.13620583713054657, 0.3499966263771057, -0.16028256714344025, -0.5898882746696472, 0.42980650067329407, 0.27551496028900146, -0.238334059715271, -0.13070791959762573, 0.6009081602096558, 0.347652405500412, -0.02479913830757141, 0.2651159465312958, 0.04723183438181877, 0.241533562541008, -0.07453111559152603, 0.24651479721069336, -0.16693975031375885, -0.7869003415107727, 0.7268329858779907, -0.5070936679840088, 0.31206652522087097, -0.6277700662612915, -0.07387670129537582, -0.3804318904876709, 0.269090861082077, -0.31363964080810547, -0.5666562914848328, -0.12773992121219635, -0.5510527491569519, -0.6938747763633728, -0.04035986587405205, 0.1340654343366623, -0.04804288223385811, 0.08472294360399246, 0.05612723156809807, 0.12952883541584015, -0.7861288189888, 0.25600114464759827, 0.26086580753326416, -0.04250433295965195, -0.1842883676290512, 0.310926228761673, 0.5252756476402283, 0.5129202008247375, -0.5132563710212708, -0.0189946498721838, 0.21582555770874023, -0.13977600634098053, 0.5911043286323547, -0.042551055550575256, -0.36569514870643616, 0.08246561884880066, 0.00012141767365392298, -0.05023644492030144, 0.17184258997440338, 0.3654119670391083, 0.6679849028587341, 0.580732524394989, 0.4945015609264374, -0.1067931056022644, -0.2641654312610626, 0.607391357421875, 0.2852960228919983, -0.09858020395040512, 0.3400944471359253, 0.6862369775772095, 0.2822655439376831, 0.09811174124479294, -0.23421813547611237, 0.6534088850021362, 0.4153430163860321, 0.0407286137342453, -0.26122286915779114, -0.27525293827056885, 0.07098771631717682, -0.07778409123420715, 0.6948884129524231, 0.4309130311012268, -0.2537911534309387, -0.4032084047794342, -0.0863099917769432, 0.11198095232248306, -0.3144700229167938, -0.011352993547916412, 0.2696215808391571, 0.25635233521461487, 0.3403891324996948, -0.2747405469417572, -0.6076089143753052, 0.30866605043411255, -0.7509356737136841, -0.04010375961661339, 0.38134390115737915, -0.22763581573963165, -0.14234627783298492, 0.2336563766002655, -0.293658047914505, 0.09504518657922745, -0.1175321638584137, 0.657975971698761, -0.02891700342297554, 0.2143029421567917, 0.6105310916900635, 0.21723535656929016, 0.19251267611980438, -0.029423773288726807, -0.11610763520002365, -0.11972898244857788, 0.32437506318092346, 0.3697779178619385, -0.008561954833567142, -0.45077282190322876, 0.48002368211746216, -0.04829278215765953, -0.3217727243900299, 0.23528540134429932, -0.30116328597068787, 0.290747731924057, -0.2660445272922516, -0.4537609815597534, -0.5620670318603516, -0.44306597113609314, -0.44014158844947815, -0.33276116847991943, 0.21890568733215332, 0.26971471309661865, 0.25415533781051636, -0.7536891102790833, 0.032919321209192276, -0.03798526152968407, 0.35101959109306335, -0.14564447104930878, -0.3952983319759369, 0.3510541319847107, 0.09241770952939987, 0.653167724609375, -0.050998151302337646, 0.2624534070491791, 0.14041534066200256, 0.2978692650794983, -0.6502806544303894, 0.16510488092899323, -0.5075348615646362, -0.10877203196287155, -0.2959628403186798, -0.18379506468772888, 1.2248536348342896, 0.5251911282539368, -0.29798322916030884, 0.3080618381500244, -0.2789131700992584, 0.10086677223443985, 0.46785035729408264, -0.5842850804328918, -0.26129642128944397, -0.3626864552497864, -0.21246087551116943, -0.41777437925338745, 0.5669761896133423, -0.12262069433927536, -0.29542770981788635, -0.21402941644191742, 0.11884605139493942, 0.3985143005847931, -0.28592613339424133, 0.9479437470436096, -0.17088288068771362, 0.09649025648832321, 0.0015669717686250806, -0.25563156604766846, -0.5678939819335938, -0.0816350057721138, -0.5106008648872375, 0.0013811842072755098, 0.018895022571086884, -0.06574541330337524, 0.30806711316108704, -0.050813332200050354, -0.18815356492996216, 0.03387456759810448, 0.16311949491500854, -0.368001788854599, -0.2217739224433899, -0.7866793870925903, -0.5412993431091309, 0.32840991020202637, 0.25668516755104065, -0.007915970869362354, -0.21035698056221008, 0.3237733542919159, 0.07074376195669174, 0.23973841965198517, 0.281276673078537, -0.560072124004364, 0.16669265925884247, 0.09461049735546112 ]
BACKGROUND Since November 2009, WHO recommends that adults infected with HIV should initiate antiretroviral therapy (ART) at CD4+ cell counts of ≤350 cells/µl rather than ≤200 cells/µl. South Africa decided to adopt this strategy for pregnant and TB co-infected patients only. We estimated the impact of fully adopting the new WHO guidelines on HIV epidemic dynamics and associated costs. METHODS AND FINDING We used an established model of the transmission and control of HIV in specified sexual networks and healthcare settings. We quantified the model to represent Hlabisa subdistrict, KwaZulu-Natal, South Africa. We predicted the HIV epidemic dynamics, number on ART and program costs under the new guidelines relative to treating patients at ≤200 cells/µl for the next 30 years. During the first five years, the new WHO treatment guidelines require about 7% extra annual investments, whereas 28% more patients receive treatment. Furthermore, there will be a more profound impact on HIV incidence, leading to relatively less annual costs after seven years. The resulting cumulative net costs reach a break-even point after on average 16 years. CONCLUSIONS Our study strengthens the WHO recommendation of starting ART at ≤350 cells/µl for all HIV-infected patients. Apart from the benefits associated with many life-years saved, a modest frontloading appears to lead to net savings within a limited time-horizon. This finding is robust to alternative assumptions and foreseeable changes in ART prices and effectiveness. Therefore, South Africa should aim at rapidly expanding its healthcare infrastructure to fully embrace the new WHO guidelines.
[ -0.005169282201677561, 0.0027498614508658648, -0.01983971893787384, 0.014166057109832764, -0.0022279818076640368, 0.013888543471693993, 0.009967782534658909, 0.0014047694858163595, -0.013988075777888298, -0.027631890028715134, 0.0028035291470587254, 0.005498269572854042, -0.003932640887796879, 0.01756463758647442, -0.0010886546224355698, -0.03712941333651543, -0.03250773996114731, 0.018467485904693604, 0.009582603350281715, 0.004728508647531271, -0.02279098704457283, -0.003972042351961136, 0.010600670240819454, -0.025128649547696114, 0.012326131574809551, 0.021966438740491867, 0.0018898993730545044, -0.01802266389131546, -0.00010840222239494324, -0.00245087593793869, 0.015551451593637466, 0.023950137197971344, 0.027117520570755005, -0.017248019576072693, 0.015073351562023163, -0.015057138167321682, -0.000980928773060441, 0.018793854862451553, 0.004888949450105429, -0.0051032304763793945, 0.0013122246600687504, -0.017116501927375793, -0.0014232936082407832, 0.014935007318854332, -0.007921839132905006, 0.011149684898555279, -0.011381959542632103, -0.019205205142498016, -0.012808602303266525, 0.015224810689687729, -0.001392192905768752, -0.016648292541503906, -0.010578442364931107, -0.025400791317224503, -0.00633970694616437, 0.0019383302424103022, 0.018700040876865387, 0.022730005905032158, -0.02069716341793537, 0.025608930736780167, -0.006602347828447819, -0.0033076563850045204, 0.015788111835718155, -0.0014062975533306599, 0.009313616901636124, -0.0668911561369896, -0.012708162888884544, 0.020917288959026337, -0.010233854874968529, -0.010885270312428474, -0.00893065519630909, 0.008061187341809273, 0.03606603667140007, -0.0039824689738452435, -0.044089242815971375, -0.006976807489991188, -0.005281529854983091, 0.026492081582546234, -0.004595015663653612, 0.019839748740196228, -0.0008295888546854258, 0.004063411150127649, 0.009699213318526745, 0.008237659931182861, -0.017524663358926773, 0.006300556473433971, -0.0172627791762352, -0.0055872006341814995, 0.03870759904384613, -0.01838635839521885, -0.005267222411930561, -0.04868047684431076, -0.029667342081665993, -0.019610200077295303, -0.01639881357550621, -0.022705934941768646, -0.03142084181308746, -0.02592194452881813, -0.009329646825790405, -0.014018132351338863, -0.003195920493453741, -0.004113274626433849, 0.011898383498191833, -0.00314039783552289, -0.0014545675367116928, 0.010842276737093925, -0.016310252249240875, 0.0018691860605031252, 0.02359955571591854, 0.0035322606563568115, 0.018539000302553177, -0.0007677627727389336, 0.012246816419064999, -0.010921487584710121, 0.007594534195959568, 0.009461751207709312, 0.010259093716740608, -0.001910992432385683, 0.013875835575163364, 0.029752783477306366, -0.007836628705263138, -0.024058926850557327, 0.003659590380266309, -0.008326699957251549, -0.004235147964209318, 0.0007980330847203732, 0.007827923633158207, 0.007446254603564739, -0.007860058918595314, 0.007609151303768158, -0.010033044964075089, 0.0011810113210231066, 0.009491465985774994, -0.03351011499762535, -0.014115524478256702, 0.008247992023825645, -0.009174082428216934, 0.03028782643377781, 0.007386406417936087, -0.008300116285681725, -0.007333914749324322, 0.006635251455008984, -0.003846127074211836, 0.008549939841032028, -0.0042864857241511345, 0.003222945611923933, -0.05705451965332031, 0.0031098551116883755, 0.019072817638516426, -0.004594042431563139, -0.005161547102034092, -0.022470954805612564, 0.026473529636859894, -0.019215809181332588, -0.006737228482961655, -0.00616930378600955, -0.03151153400540352, -0.030192993581295013, -0.008108423091471195, 0.02816266193985939, -0.015007487498223782, 0.012928798794746399, -0.008642436936497688, 0.010330012068152428, 0.037387341260910034, -0.004128105007112026, -0.015901099890470505, 0.004507643170654774, 0.008679507300257683, 0.006475563161075115, -0.009664971381425858, 0.007996410131454468, -0.004464243073016405, 0.008213206194341183, -0.01234414055943489, -0.008801362477242947, 0.0071495273150503635, 0.009277286008000374, -0.006664070766419172, 0.06638994812965393, 0.02114247903227806, 0.02175034023821354, -0.0037399325519800186, 0.004146340768784285, 0.007879124023020267, 0.010856738314032555, 0.0009766316507011652, -0.005542033817619085, -0.00641498900949955, 0.01989951729774475, -0.0006285968702286482, 0.007537582889199257, -0.017334740608930588, -0.005421864800155163, -0.027475986629724503, 0.004032786935567856, 0.01462934073060751, 0.00975493062287569, -0.01895594783127308, 0.0037859566509723663, -0.012462135404348373, -0.009685209020972252, 0.045076243579387665, 0.0030178094748407602, -0.042761169373989105, 0.002369740279391408, -0.02030583843588829, -0.013085445389151573, -0.015358000993728638, -0.02184627577662468, 0.03684417903423309, -0.011275462806224823, 0.0050089010037481785, -0.005355348810553551, -0.018722357228398323, 0.00030133919790387154, 0.016923321411013603, 0.0052781179547309875, 0.002336643636226654, -0.014998439699411392, -0.0012753269402310252, 0.024461740627884865, 0.0031325556337833405, 0.03215979412198067, 0.023592209443449974, 0.007132343947887421, -0.00832063052803278, 0.009476609528064728, -0.007268620189279318, 0.00021403562277555466, -0.007098735310137272, 0.001957815373316407, -0.011601429432630539, 0.014384051784873009, 0.02203591912984848, -0.0018300453666597605, 0.014085439033806324, -0.015407036058604717, 0.024783248081803322, -0.018175572156906128, -0.006168686784803867, -0.0335208997130394, 0.004818995948880911, -0.004799393936991692, 0.003068915568292141, 0.005291839130222797, 0.022215979173779488, -0.01335984282195568, -0.027232423424720764, 0.003408248769119382, 0.007059711962938309, -0.011951633729040623, 0.01515934243798256, 0.004183368757367134, 0.028414394706487656, -0.02151467092335224, 0.018598897382616997, -0.013146137818694115, 0.023193933069705963, 0.0022208448499441147, 0.01144876703619957, 0.00556130800396204, 0.0005471911281347275, -0.03108055517077446, 0.0009177085012197495, -0.012402966618537903, -0.0005886792205274105, 0.006970272399485111, 0.00828168448060751, 0.0022746361792087555, 0.006901395041495562, -0.00491809006780386, 0.0014754467410966754, -0.08119367063045502, -0.018298767507076263, -0.006598309148102999, 0.0006381943821907043, 0.009044256061315536, 0.004919816739857197, -0.0006156758172437549, 0.017065197229385376, -0.009863501414656639, 0.033404119312763214, -0.00192312803119421, 0.037791136652231216, -0.010784686543047428, -0.010067056864500046, -0.009764835238456726, -0.0033016831148415804, 0.005361177492886782, 0.02025558426976204, -0.015937423333525658, -0.004654926713556051, -0.01039606798440218, 0.019196216017007828, 0.030986927449703217, -0.006349025294184685, 0.002757851965725422, -0.0019044061191380024, 0.009257444180548191, -0.0082170981913805, -0.03351501747965813, 0.0034537140745669603, 0.012119531631469727, -0.019713010638952255, 0.027202308177947998, -0.0039375536143779755, -0.018249597400426865, -0.014107927680015564, -0.010176600888371468, -0.013082632794976234, -0.020381616428494453, -0.007183179724961519, -0.0029732384718954563, 0.005846252664923668, 0.011698833666741848, 0.008371209725737572, 0.0227486714720726, 0.006313204299658537, -0.008601602166891098, 0.0031478512100875378, 0.01896587200462818, 0.006020276807248592, -0.003638345282524824, 0.00485324626788497, -0.012562054209411144, 0.01163853146135807, -0.014507506042718887, -0.01357215829193592, -0.055722691118717194, 0.0251461248844862, -0.012579083442687988, -0.016993088647723198, 0.01706846058368683, -0.008433574810624123, 0.005424109753221273, 0.014084399677813053, -0.0083311153575778, 0.017806915566325188, 0.009741457179188728, 0.00040228571742773056, -0.009983777068555355, 0.014659516513347626, -0.009077940136194229, 0.0047936951741576195, -0.004001031629741192, -0.017455685883760452, -0.002494365442544222, -0.00360512756742537, -0.021833771839737892, -0.0035312706604599953, 0.017758775502443314, 0.00163185503333807, 0.014195894822478294, 0.014749160967767239, -0.018827158957719803, -0.007954252883791924, 0.0029891598969697952, -0.013083775527775288, 0.010880962945520878, 0.005131946876645088, 0.012960804626345634, -0.02014244720339775, 0.013493898324668407, 0.01613364927470684, -0.006257608067244291, 0.012352916412055492, 0.002570818644016981, -0.021587882190942764, 0.001462552580051124, 0.017834529280662537, -0.008460462093353271, 0.009059324860572815, -0.022499796003103256, -0.012176260352134705, 0.002303429413586855, -0.013897309079766273, -0.019964035600423813, 0.014132993295788765, 0.020219620317220688, 0.0005307937972247601, 0.0059142764657735825, -0.0027650403790175915, 0.021421710029244423, 0.006928609684109688, -0.006918270140886307, 0.00337388226762414, 0.009659064933657646, 0.031025473028421402, 0.012302111834287643, 0.021507468074560165, 0.07233317941427231, -0.021936357021331787, -0.009355273097753525, -0.022089842706918716, -0.009198919869959354, -0.012197321280837059, -0.009264467284083366, -0.012401888146996498, -0.007952042855322361, -0.018317611888051033, 0.011414805427193642, -0.021987905725836754, 0.0022582903038710356, -0.01886286772787571, -0.0033914886880666018, -0.0014673920813947916, 0.010755868628621101, -0.006537481676787138, 0.012840528972446918, -0.026642534881830215, -0.022474117577075958, 0.02724364772439003, -0.014948870986700058, -0.016640812158584595, 0.010119341313838959, -0.0020624154713004827, 0.0059047783724963665, -0.01217136811465025, -0.012754502706229687, 0.006246897391974926, -0.0008143179584294558, 0.03769119828939438, -0.0036278790794312954, -0.0050672139041125774, 0.01598205789923668, 0.01835610903799534, -0.02266113832592964, 0.04425637423992157, 0.02695799060165882, -0.012425200082361698, 0.009992167353630066, -0.018822800368070602, -0.0012395735830068588, 0.009302964434027672, -0.0037842518649995327, 0.0030110161751508713, -0.0013752193190157413, -0.007941036485135555, -0.026256898418068886, 0.013544566929340363, -0.0011296321172267199, -0.0030705719254910946, 0.013768264092504978, 0.00276901014149189, -0.006950743962079287, -0.02968369796872139, -0.0010501407086849213, -0.010661822743713856, -0.0014690312091261148, -0.02474479377269745, -0.018442746251821518, -0.000944649102166295, 0.008997485041618347, 0.012875743210315704, -0.003698535030707717, -0.011130053550004959, 0.008932014927268028, 0.003997609950602055, -0.02164418250322342, 0.005805250257253647, 0.0017810510471463203, -0.01826387457549572, -0.019729312509298325, 0.006246690172702074, -0.06820210814476013, 0.01737269014120102, -0.02864590846002102, 0.0011503137648105621, 0.02204247936606407, -0.00895315408706665, 0.0118458466604352, -0.0038273485843092203, 0.004776169545948505, -0.025382552295923233, 0.0037444615736603737, -0.022836793214082718, -0.00794256292283535, -0.07439995557069778, -0.036160990595817566, 0.0042453971691429615, -0.013225161470472813, 0.006317404564470053, -0.0068384092301130295, -0.017775192856788635, 0.012974319979548454, -0.006237621884793043, -0.008427392691373825, -0.01606292463839054, 0.0031453189440071583, 0.021674713119864464, 0.005942319519817829, 0.015279537066817284, -0.003573233727365732, -0.02030414156615734, -0.013302262872457504, -0.02113262563943863, 0.005771698895841837, 0.013040607795119286, -0.010141967795789242, -0.023980144411325455, -0.013021882623434067, 0.003920428920537233, -0.08090917021036148, 0.018955836072564125, -0.0243059191852808, -0.03451763838529587, 0.010724139399826527, -0.011643563397228718, 0.009714426472783089, -0.008078115060925484, 0.006981757469475269, -0.015205619856715202, -0.0018255712930113077, -0.010165750980377197, 0.0019944144878536463, -0.024687226861715317, 0.034888796508312225, -0.0011763032525777817, 0.014974908903241158, 0.013703272677958012, -0.0021389005705714226, 0.016788581386208534, -0.025362148880958557, 0.030398070812225342, -0.005663769785314798, 0.017119992524385452, -0.003942904993891716, 0.0036843502894043922, -0.014979969710111618, 0.011784345842897892, -0.002364146988838911, 0.006949735805392265, 0.0047691138461232185, 0.03950983285903931, -0.00505877984687686, -0.01281951367855072, -0.005731923505663872, -0.015070009045302868, 0.0006267502903938293, -0.02394723705947399, 0.03315088152885437, -0.000035279663279652596, -0.003469653893262148, -0.006700765807181597, 0.0010180054232478142, 0.00878953468054533, 0.021027464419603348, 0.006909750401973724, 0.011126134544610977, -0.0032207590993493795, 0.017620235681533813, -0.014572706073522568, 0.008507218211889267, 0.0002442598342895508, -0.008960330858826637, -0.022126350551843643, 0.005452968180179596, -0.002096232958137989, -0.008554331958293915, -0.0043767839670181274, -0.0037067553494125605, -0.000031593022868037224, -0.01876470074057579, 0.007695394102483988, 0.0040433816611766815, 0.07158861309289932, -0.003483141539618373, 0.00879061408340931, -0.0039509367197752, 0.004637251608073711, -0.0012201691279187799, -0.019911637529730797, 0.009908122010529041, -0.03467777371406555, -0.005856116767972708, -0.013389227911829948, -0.0043789539486169815, -0.030580922961235046, 0.009312605485320091, 0.005825006403028965, 0.019176829606294632, 0.008023042231798172, 0.02431522309780121, 0.012860892340540886, -0.004071417264640331, 0.011510331183671951, 0.01748497039079666, -0.030718844383955002, -0.01866552233695984, 0.03198522701859474, 0.004834766965359449, -0.004453687462955713, 0.011185343377292156, -0.029827596619725227, 0.003846811829134822, -0.010341418907046318, -0.005293074995279312, 0.010710416361689568, -0.006021562032401562, 0.010148940607905388, 0.008111566305160522, -0.004305179696530104, 0.00969122163951397, 0.0029112889897078276, -0.009906196035444736, 0.000034119002521038055, -0.02301102504134178, 0.005645500496029854, -0.024209287017583847, 0.017016641795635223, -0.03404721990227699, -0.016980506479740143, 0.0015244276728481054, -0.020471319556236267, 0.00691062631085515, -0.006052241660654545, 0.004266100469976664, -0.008331796154379845, -0.0021690204739570618, -0.0172208771109581, -0.010131682269275188, -0.009267287328839302, 0.017808102071285248, -0.006520937662571669, -0.0026605618186295033, 0.00797554012387991, -0.02003663033246994, 0.007781376130878925, -0.010548545978963375, 0.002915480872616172, -0.0046388087794184685, 0.006423516198992729, -0.013365041464567184, 0.005343707278370857, 0.01220487616956234, 0.0027100536972284317, 0.013395968824625015, 0.008770216256380081, 0.00568764191120863, 0.012259570881724358, 0.005419970490038395, 0.03164270892739296, -0.01815726049244404, 0.007545582018792629, 0.01350394170731306, -0.01303071342408657, 0.021264459937810898, 0.03274834156036377, -0.011964535340666771, -0.0256173275411129, -0.01830173470079899, 0.010757713578641415, -0.002880099229514599, -0.0063763754442334175, 0.0032283198088407516, 0.018596837297081947, 0.00924772396683693, 0.0038487627170979977, -0.005802462808787823, 0.008933309465646744, 0.03358558565378189, -0.020493250340223312, -0.001492651179432869, 0.012610247358679771, -0.026061732321977615, 0.009828762151300907, -0.005121666006743908, -0.0038400269113481045, 0.031291261315345764, -0.009198751300573349, 0.0010321933077648282, 0.006148004904389381, 0.005518266465514898, 0.00872335396707058, 0.01437282469123602, -0.003981037996709347, -0.0008036368526518345, 0.03551732376217842, -0.017416149377822876, -0.019477777183055878, -0.0018811891786754131, 0.003108480479568243, 0.0005936683155596256, -0.007680210284888744, -0.014604893513023853, -0.017219599336385727, -0.009854788891971111, 0.018678631633520126, 0.04680246859788895, -0.00324883870780468, 0.0012616051826626062, -0.004214195068925619, -0.010465452447533607, 0.020254740491509438, 0.002619393402710557, 0.01786508411169052, 0.00274724792689085, -0.006928677670657635, 0.014791064895689487, -0.004068257752805948, 0.002862472552806139, 0.011631232686340809, 0.019261769950389862, -0.00108237168751657, 0.005362393334507942, 0.04149444028735161, -0.005489526316523552, 0.00887439213693142, 0.003641945542767644, 0.008675528690218925, -0.00890478678047657, 0.011899391189217567, 0.008898245170712471, 0.013319287449121475, 0.0017610499635338783, 0.004769755527377129, 0.010449342429637909, 0.0034820977598428726, -0.0030252402648329735, 0.0022911031264811754, 0.008150754496455193, 0.014540325850248337, -0.021843090653419495, -0.014209190383553505, -0.019349556416273117, -0.017380911856889725, -0.008721347898244858, -0.01040390133857727, 0.005902004893869162, -0.017390795052051544, 0.037075646221637726, 0.005247884429991245, -0.0017747953534126282, 0.0015809439355507493, 0.0025548445992171764, 0.01787787675857544, -0.005850677378475666, 0.015698960050940514, 0.027243034914135933, -0.02487892657518387, 0.0036787730641663074, 0.011837722733616829, 0.006432321388274431, 0.003185393288731575, 0.025178972631692886, -0.005967010743916035, -0.009774155914783478, 0.012441224418580532, -0.010215232148766518, 0.0029449891299009323, -0.022090235725045204, -0.0019005865324288607, 0.022088635712862015, 0.00416464963927865, -0.0018551244866102934, -0.004785272292792797, -0.005264542065560818, -0.011832534335553646, 0.007764176465570927, 0.028866607695817947, 0.021018553525209427, -0.00048011261969804764, -0.02162790298461914, 0.0034204742405563593, -0.01304089929908514, -0.009744135662913322, 0.004204354248940945 ]
[ 0.597126841545105, 0.06931174546480179, 0.068680040538311, -0.14652931690216064, 0.03456617146730423, 0.533846378326416, 0.49220171570777893, -0.367166131734848, -0.22009235620498657, -0.5162790417671204, 0.3568100929260254, 0.12931445240974426, -0.22882486879825592, -0.12224318832159042, -0.4191172122955322, 0.7583067417144775, 0.8055012226104736, 0.37845367193222046, -0.3631945252418518, -0.379655122756958, -0.2340996414422989, -0.8470600247383118, 0.4416791498661041, 0.18348221480846405, 0.20269811153411865, -0.11249306797981262, 0.7907171249389648, -0.07576936483383179, 0.15647168457508087, -0.14625848829746246, -0.16687451303005219, 0.4933236837387085, 0.1455402821302414, 0.048693928867578506, 0.3137420117855072, -0.33130884170532227, 0.16146130859851837, 0.23949381709098816, 0.2541336417198181, -0.43611544370651245, -0.4019962549209595, -0.007826966233551502, -0.2545801103115082, 0.3461495637893677, 0.14182977378368378, -0.5707059502601624, -0.8187140822410583, 0.6727347373962402, -0.3599607050418854, 0.5754952430725098, 0.09834600985050201, 0.22151795029640198, -0.02174125425517559, 0.25414884090423584, 0.0917273685336113, 0.04049297422170639, -0.4089510142803192, 0.01507973950356245, 0.6735991835594177, -0.3824203610420227, 0.032744504511356354, 0.06628678739070892, -0.12433993071317673, 0.2759024500846863, -0.26971468329429626, 0.6291641592979431, 0.4046795666217804, -0.0219119843095541, 0.42989596724510193, -0.5387579202651978, 0.1571708619594574, -0.5040491223335266, -0.4656999409198761, -0.07857468724250793, -0.18339243531227112, 0.12964379787445068, -0.21549361944198608, -0.29427462816238403, 0.12396145612001419, -0.024172937497496605, -0.07263366878032684, -0.6395168900489807, -0.17169655859470367, -0.7176503539085388, 0.7443079352378845, 0.3177030384540558, -0.1733393669128418, 0.03235149011015892, -0.1324954628944397, -0.19730350375175476, -0.05614183843135834, -0.2011180967092514, 0.103476881980896, 0.9112706184387207, 0.1326843798160553, 0.33806174993515015, -0.07955358177423477, -0.19001179933547974, 0.37301430106163025, 0.18030105531215668, -0.11578354984521866, 0.19236861169338226, -0.017814483493566513, 0.1060463935136795, -0.39651232957839966, -0.1979387253522873, 0.07779408991336823, -0.27131152153015137, -0.5346463918685913, 0.04068621248006821, -0.4010842740535736, 0.07871656119823456, -0.06600884348154068, -0.381401002407074, 0.09871653467416763, 0.1853853464126587, 0.26848259568214417, -0.4247947633266449, -0.1421213001012802, 0.17565512657165527, -0.2928912937641144, 0.6819213628768921, -0.03292016685009003, 0.9211260676383972, 0.11928441375494003, 0.06351647526025772, 0.5426360368728638, 0.5547118782997131, -0.06151597574353218, 0.8143076300621033, 0.05162391439080238, 0.3093005418777466, -0.035284362733364105, 0.0784544125199318, 0.16189028322696686, -0.044840339571237564, 0.31804701685905457, 0.2962006628513336, 0.2385738492012024, -0.04666486382484436, -0.41303056478500366, -0.22828781604766846, -0.11098794639110565, 0.18512393534183502, 0.35259440541267395, -0.8413569927215576, 0.13180270791053772, -0.5335381627082825, 0.00415199575945735, -0.22793418169021606, 0.20947672426700592, 0.1314268857240677, -0.4114764928817749, -0.32227379083633423, -0.20333869755268097, 0.518772542476654, -0.32972460985183716, -0.28958550095558167, -0.2924174964427948, 0.10378405451774597, 0.6895383596420288, 0.44970545172691345, -0.02077973261475563, 0.05887215584516525, 0.5592113733291626, -0.06198570877313614, 0.15014371275901794, -0.14387784898281097, 0.02191992662847042, 0.2549336850643158, -0.5174979567527771, -0.2339925318956375, -0.3666188418865204, -0.3524901866912842, -0.28468337655067444, 0.2372029572725296, 0.24862392246723175, -0.011454956606030464, 0.0032126244623214006, 0.233933225274086, -0.4830113649368286, -0.02604522556066513, 0.20942428708076477, -0.4926398694515228, 0.26843956112861633, -0.026539644226431847, 0.47563469409942627, 0.3079701364040375, 0.3346027433872223, 0.6136988997459412, -0.039524100720882416, -0.2996755838394165, 0.9412915706634521, -0.588918924331665, 1.3383724689483643, -0.16864155232906342, -0.27616584300994873, 1.2120376825332642, 0.201614648103714, 0.15382690727710724, 0.0385548435151577, 0.24105694890022278, 0.7568359971046448, -0.08162012696266174, -0.8789727091789246, -0.33847954869270325, -0.11440852284431458, -0.38004806637763977, -0.15167419612407684, -0.06861546635627747, 0.5572792291641235, -0.32411500811576843, -0.5620367527008057, -0.705815851688385, 0.3602820634841919, 0.22245042026042938, 0.18110376596450806, 0.06158502772450447, -0.03994714468717575, -0.378924697637558, 0.1339300274848938, -0.8059559464454651, 0.3141286373138428, 0.08501141518354416, 0.03944948688149452, 0.5583161115646362, 0.5636551380157471, 0.26949599385261536, 0.8157653212547302, -0.7830561399459839, -0.062260497361421585, 0.3554304838180542, 0.6357290148735046, -0.3975977599620819, -0.24905791878700256, 0.12324277311563492, 0.21284697949886322, -0.04130737483501434, 0.07616707682609558, 0.1604134440422058, -0.025865012779831886, 0.5829261541366577, -0.4573167562484741, -0.11661838740110397, 0.15030962228775024, 0.04725761339068413, -0.04903550446033478, 0.3554157018661499, -0.5437113046646118, 0.23610344529151917, -0.030102595686912537, -0.04534091427922249, 0.028701845556497574, -0.3611915409564972, 0.07041724026203156, 0.22497470676898956, -0.07858021557331085, -0.5697385668754578, 0.10586342960596085, -0.5730454325675964, -0.19314712285995483, -0.03304531052708626, 0.03364364057779312, 0.4696543514728546, 0.26841506361961365, -0.3396168351173401, -0.5633060932159424, -0.6578108072280884, 0.9674890637397766, 0.4239603281021118, 0.5123075842857361, 0.37538596987724304, -0.4958770275115967, 0.12929482758045197, 0.3463405966758728, -0.4501397907733917, 0.35847365856170654, 0.8567721247673035, -0.15138305723667145, -0.4863818287849426, -0.15005865693092346, 0.4810182452201843, 1.0546666383743286, -0.27315792441368103, 0.15014256536960602, -0.351036936044693, 0.035514410585165024, -0.22126449644565582, -0.8709580898284912, -0.07153552770614624, -0.06730444729328156, 0.4808346629142761, -0.24181470274925232, -0.041042931377887726, 0.06992187350988388, 0.36521562933921814, -0.42056214809417725, 0.3508746922016144, 0.6584680676460266, -0.3141903579235077, 0.3485695719718933, 0.09728497266769409, -0.6838496923446655, -0.0012041430454701185, -0.12065093964338303, -0.029256882146000862, -0.43920108675956726, -0.15648894011974335, -5.919848442077637, 0.41528505086898804, -0.3544114828109741, -0.0714603140950203, -0.5276962518692017, 0.0479404479265213, 1.0176942348480225, -0.1172962337732315, 0.3812505006790161, -0.29871079325675964, 0.050418633967638016, 0.23948530852794647, 0.42937415838241577, 0.10290531814098358, 0.23151735961437225, 0.6098869442939758, 0.28955259919166565, -0.40835297107696533, 0.570372462272644, 0.10041838884353638, 0.2098073661327362, -0.3638140559196472, 0.05055343359708786, 0.0820932537317276, 0.5537406802177429, 0.373693585395813, -1.197214126586914, 0.24194246530532837, 0.018280349671840668, -0.4724057912826538, 0.3745460510253906, -0.7784306406974792, -0.27274078130722046, 0.01862090267241001, 0.16726571321487427, 0.2902364730834961, 0.31792697310447693, -0.2254607230424881, -0.22554852068424225, -0.5337018370628357, 0.08396075665950775, 0.5872858166694641, -0.2182203084230423, 0.07040706276893616, -0.04207095131278038, -0.27059677243232727, 0.0505133718252182, 0.1605932116508484, -0.1477019041776657, 0.659070611000061, 0.11466057598590851, 0.10099911689758301, -0.2370547652244568, 0.6693364977836609, -0.0646507740020752, -0.0005799891659989953, -0.257964164018631, 0.539668619632721, 0.1169777661561966, 0.14430183172225952, 0.021911725401878357, -0.29790619015693665, 0.20575177669525146, -0.5517067909240723, 0.2953352630138397, 0.10059183835983276, -0.7304983735084534, -0.37946587800979614, -0.17530310153961182, -0.18179422616958618, -0.2415606677532196, -0.10992009937763214, -0.05774981528520584, -0.7959507703781128, -0.004343767650425434, -0.5169535875320435, 0.15702073276042938, -0.0700751319527626, -0.029735883697867393, -0.34612134099006653, 0.07792354375123978, -0.24708238244056702, 0.33329182863235474, -0.08086493611335754, -0.1693267822265625, -0.2082434445619583, -0.25158095359802246, -0.19188763201236725, -0.18001224100589752, -0.07706894725561142, 0.6573315858840942, -0.25610384345054626, 0.08704414963722229, 0.18340986967086792, 0.15217314660549164, 0.5841591358184814, 0.6159378886222839, -0.18600091338157654, 0.16491590440273285, -0.26228153705596924, 0.6871293783187866, -0.04424826800823212, -0.5365436673164368, -1.2037279605865479, 0.05682968348264694, 0.1389741450548172, -0.49095797538757324, -0.11906015872955322, 0.6258408427238464, -0.7837702035903931, -0.07781403511762619, 0.1724538952112198, -0.6548680067062378, -0.027518397197127342, 0.814210057258606, -0.5409737229347229, 0.06387359648942947, -0.4127081334590912, 0.3833369016647339, -0.2295914888381958, 0.33342745900154114, 0.1927206665277481, -0.03447265550494194, 0.6544817686080933, 0.2618088126182556, -0.633340060710907, 0.2359873652458191, 0.4505373537540436, -0.624232828617096, -0.012909246608614922, 0.0007285769679583609, 0.412579745054245, -0.32180240750312805, -0.6056990027427673, 0.23213015496730804, -0.25540533661842346, -0.5196511149406433, -0.23553210496902466, 0.5710110664367676, 0.4592580795288086, -0.11724153906106949, 0.07433172315359116, -0.27563244104385376, 0.5733848214149475, 0.5479548573493958, -0.030843056738376617, 0.023411886766552925, -0.4234940707683563, -0.4257865846157074, -0.3824826180934906, 0.2691553235054016, 0.19811901450157166, 0.25738540291786194, -0.05485745891928673, -0.36547449231147766, -0.2594679594039917, -0.0001015647139865905, -0.05273042246699333, -0.046293485909700394, -0.10213042050600052, 0.4756874740123749, 0.27828100323677063, -1.139357089996338, 0.10721539705991745, 0.1739308387041092, -0.5122076869010925, 0.20348703861236572, -0.49124768376350403, 0.19817465543746948, 0.1811441034078598, 0.17503023147583008, -0.7747795581817627, 0.11921770125627518, -0.38051337003707886, -0.009488045237958431, -0.30292317271232605, -0.26387977600097656, 0.35387060046195984, -0.2215961068868637, 0.22531332075595856, 0.33640846610069275, -0.03911861032247543, -0.5113727450370789, 0.5111486911773682, 1.0228317975997925, 0.29458194971084595, -0.003792467759922147, -0.32570570707321167, -0.009219356812536716, -0.509589672088623, 0.2049788534641266, -0.066922128200531, 0.3450017273426056, 0.36686527729034424, 0.008167341351509094, -0.6542738080024719, 0.16190962493419647, 0.18940460681915283, -0.17413613200187683, -0.09079593420028687, -0.3260214626789093, 0.51323401927948, -0.36072471737861633, 0.5435207486152649, 0.22511602938175201, 0.011967678554356098, 0.10532575845718384, 0.08695472031831741, 0.018063435330986977, -0.45961135625839233, -0.1682087779045105, -0.2580338418483734, -0.4532186985015869, 0.667317807674408, -0.5743592381477356, 0.26975733041763306, -0.020887669175863266, -0.1706138551235199, -0.49487197399139404, 0.20004314184188843, 0.14197027683258057, -0.2785895764827728, -0.29031839966773987, -0.05384359508752823, -0.18383532762527466, 0.4032141864299774, 0.8546282649040222, -0.9296169877052307, -0.2866329252719879, 0.5152748823165894, -0.3245948255062103, 0.29544851183891296, 0.17391911149024963, 0.27437764406204224, -0.9397156834602356, 0.03025980293750763, -0.15362226963043213, -0.14647357165813446, 0.21291731297969818, 0.5697001218795776, 0.014899792149662971, 0.2018778771162033, -0.18138428032398224, -0.41269204020500183, 0.1134401485323906, 0.17363682389259338, -0.12287742644548416, -0.35720473527908325, -0.6541034579277039, 0.27695268392562866, -0.06176816672086716, -0.5088099241256714, 0.21597662568092346, -0.4445618987083435, 0.5251020193099976, 0.07045771926641464, -0.6249400973320007, -0.10356723517179489, 0.026913374662399292, 0.4958111643791199, -0.22518227994441986, -0.7284899353981018, 0.053400252014398575, -0.23436161875724792, -0.10536127537488937, -0.4528414309024811, -0.12956830859184265, -0.6393651962280273, -0.22552688419818878, -0.6125559210777283, -0.2938714921474457, -0.214163139462471, 0.7936525344848633, 0.39454570412635803, 0.23526354134082794, -0.25663653016090393, -0.42489510774612427, 0.013209277763962746, -0.3726826608181, 0.14230841398239136, -0.6231683492660522, -0.4451325535774231, 0.25335589051246643, -0.28921031951904297, -0.0015663276426494122, -0.20872637629508972, 0.27200955152511597, -0.0033598013687878847, -0.3797309398651123, -0.47178998589515686, 0.1283697485923767, -0.4227844476699829, -0.4707523286342621, -0.3837200403213501, -0.014474683441221714, 0.178877592086792, 0.4893823266029358, 0.1371718794107437, 0.5353140234947205, -0.7694410085678101, -0.3444118797779083, 0.9080226421356201, 0.41681745648384094, -0.655098557472229, 0.16382916271686554, 0.10517867654561996, 0.38106560707092285, 0.06155867874622345, 0.07621297985315323, 0.1365641951560974, 0.3067445158958435, 0.05535924807190895, 0.34558698534965515, 0.5181336402893066, -0.6564489603042603, 0.336556613445282, 0.0022533743176609278, -0.5341886878013611, 0.38656532764434814, 0.14608576893806458, -0.08204717934131622, 0.7242264151573181, 0.37165069580078125, 0.2368471771478653, -0.13479803502559662, 0.626223623752594, -0.08833853900432587, 0.4436403214931488, -0.016680512577295303, 0.07878963649272919, 0.3589399456977844, 0.5576252341270447, -0.5650582313537598, 0.19329598546028137, 0.14399389922618866, 0.6593588590621948, 0.38261932134628296, -0.22506816685199738, -0.21555005013942719, 0.08173636347055435, 0.6355741620063782, 0.31972286105155945, -0.07832221686840057, -0.23614349961280823, -0.19658449292182922, 0.04084012284874916, 0.09075535088777542, -0.019917519763112068, 0.12365814298391342, 0.44886651635169983, 0.07782678306102753, -0.3733775317668915, -0.559460461139679, 0.29439473152160645, -0.6194524168968201, 0.4316684901714325, 0.22426995635032654, -0.33176282048225403, -1.0684224367141724, 0.25805002450942993, 0.35873931646347046, 0.11956488341093063, -0.4785793721675873, 0.3241914212703705, -0.6189760565757751, 0.03875582292675972, 0.366278737783432, -0.03798248618841171, -0.1670694798231125, -0.3123106062412262, 0.04700484126806259, -0.24516768753528595, -0.14435650408267975, -0.008330699987709522, 0.020892437547445297, -0.32315194606781006, 0.047273389995098114, -0.1573534458875656, -0.0744672641158104, 0.36259889602661133, -0.20285414159297943, -0.005766014568507671, -0.30246320366859436, -0.20829983055591583, 0.370268315076828, -0.4398849606513977, -0.08484351634979248, 0.20073643326759338, -0.15419289469718933, -0.2461562305688858, -0.2199878841638565, -0.5413739681243896, 0.35797837376594543, 0.2979557514190674, -0.49978089332580566, 0.3526058495044708, -0.2739390432834625, 0.5919100642204285, 0.26270511746406555, 0.5584405660629272, -0.3315521776676178, -0.2072325199842453, -0.18238691985607147, 0.6154312491416931, -0.12983445823192596, 0.5466968417167664, -0.4994489550590515, -0.43202489614486694, -0.43780142068862915, 0.026734916493296623, 0.8888909220695496, 0.051780905574560165, -0.2314632385969162, -0.43528884649276733, -0.12329591810703278, 0.6403834819793701, 0.19328969717025757, -0.21521084010601044, -0.12311425060033798, -0.01954871229827404, -0.4218801259994507, -0.777511477470398, 0.22977107763290405, 0.1583363115787506, -0.099807508289814, -0.3125596344470978, 0.6838446855545044, 0.49366670846939087, -0.13005484640598297, 0.6278567910194397, -0.02602623775601387, -0.16163277626037598, -0.6630088686943054, 0.6759728789329529, -0.7503398656845093, 0.392549067735672, 0.1895568072795868, 0.48673567175865173, 0.2578941583633423, -0.19896632432937622, 0.15579454600811005, -0.6027895212173462, -0.04023737832903862, 0.03906826674938202, -0.06298678368330002, 0.6122049689292908, -0.08979694545269012, -0.04142659530043602, -0.6587798595428467, 0.3710300028324127, -0.17215105891227722, -0.49158239364624023, -0.1232728511095047, -0.14818918704986572, -0.3237057328224182, -0.13104207813739777, 0.03281376138329506, -0.5582274794578552, 0.19068636000156403, -0.34101125597953796 ]
Mitochondrial division is important for mitochondrial distribution and function. Recent data have demonstrated that ER-mitochondria contacts mark mitochondrial division sites, but the molecular basis and functions of these contacts are not understood. Here we show that in yeast, the ER-mitochondria tethering complex, ERMES, and the highly conserved Miro GTPase, Gem1, are spatially and functionally linked to ER-associated mitochondrial division. Gem1 acts as a negative regulator of ER-mitochondria contacts, an activity required for the spatial resolution and distribution of newly generated mitochondrial tips following division. Previous data have demonstrated that ERMES localizes with a subset of actively replicating mitochondrial nucleoids. We show that mitochondrial division is spatially linked to nucleoids and that a majority of these nucleoids segregate prior to division, resulting in their distribution into newly generated tips in the mitochondrial network. Thus, we postulate that ER-associated division serves to link the distribution of mitochondria and mitochondrial nucleoids in cells. DOI:http://dx.doi.org/10.7554/eLife.00422.001.
[ -0.0059527261182665825, 0.008167698979377747, -0.01077834889292717, 0.017162740230560303, -0.02408818155527115, -0.0012392780045047402, 0.009846510365605354, -0.0026869848370552063, -0.008495086804032326, -0.006347795017063618, -0.015011955052614212, 0.016062118113040924, -0.005070812068879604, 0.018520774319767952, -0.016062483191490173, -0.005706497468054295, -0.01679649017751217, 0.006850725971162319, 0.005650664679706097, 0.016953591257333755, -0.0010636800434440374, 0.01464427262544632, 0.010451799258589745, -0.002847581170499325, -0.007196569815278053, 0.017035935074090958, 0.0033456142991781235, -0.019910749047994614, 0.0006411517970263958, 0.016396168619394302, -0.004777662921696901, -0.014856277965009212, 0.008424920961260796, -0.002531834412366152, 0.0014458820223808289, -0.01604817435145378, -0.006325055845081806, 0.03760017454624176, 0.0061137480661273, -0.0038116062059998512, 0.011717118322849274, -0.004694841802120209, 0.005250146612524986, 0.0054437569342553616, -0.007699918933212757, 0.010078631341457367, 0.006713812239468098, 0.006309176795184612, -0.008702388033270836, 0.0048504360020160675, 0.0010008441749960184, 0.0035689249634742737, -0.006452822592109442, 0.004941939376294613, -0.005849548615515232, -0.010309979319572449, 0.018865937367081642, -0.00964327435940504, -0.00020322157070040703, 0.018669120967388153, -0.004862496629357338, -0.013643835671246052, -0.00686468044295907, -0.02530009299516678, 0.0030479049310088158, -0.06693805754184723, -0.0005050808540545404, 0.010914510115981102, 0.00826310459524393, -0.01109671127051115, -0.006561795249581337, 0.0036896895617246628, -0.04000963270664215, -0.0037781342398375273, 0.01634513959288597, -0.006277736276388168, -0.0214048121124506, 0.02368263714015484, 0.04098164290189743, 0.008248969912528992, 0.013835910707712173, -0.0067734261974692345, -0.019842658191919327, 0.016380388289690018, 0.005598386283963919, -0.0071120779030025005, -0.018370388075709343, -0.0022453931160271168, 0.021045450121164322, -0.005658040288835764, -0.002465181052684784, 0.018283788114786148, -0.013259485363960266, -0.012933950871229172, 0.005646000616252422, -0.0004709041677415371, -0.006111671216785908, 0.022549238055944443, -0.01642797328531742, 0.01696932502090931, -0.009346307255327702, 0.04191429913043976, 0.02148420736193657, 0.0034138699993491173, -0.013057510368525982, 0.007750575430691242, 0.006958526559174061, 0.0016600759699940681, 0.008582251146435738, 0.01418033055961132, 0.012739389203488827, -0.0317378044128418, -0.003578182775527239, 0.014133225195109844, -0.00021122535690665245, 0.011377964168787003, 0.0028174533508718014, 0.0062574646435678005, 0.009931037202477455, -0.004355111625045538, 0.022647107020020485, -0.0017455087509006262, 0.002104195300489664, 0.014918481931090355, 0.0029335287399590015, -0.0026214951649308205, -0.013338202610611916, -0.008046972565352917, 0.010843535885214806, 0.009102021344006062, -0.00810147263109684, -0.002037706784904003, 0.016848249360919, -0.019819458946585655, -0.008483752608299255, 0.004821044858545065, -0.012346424162387848, -0.006979228928685188, -0.01733000949025154, -0.024654652923345566, 0.024966565892100334, 0.012026187032461166, 0.0044923946261405945, 0.013937398791313171, 0.018577400594949722, 0.0062602488324046135, -0.01046084240078926, -0.018610257655382156, -0.0006187711842358112, -0.008686327375471592, -0.004153046756982803, -0.010358797386288643, -0.009458405897021294, -0.00197944906540215, -0.034377433359622955, -0.01752174273133278, -0.024846181273460388, 0.0024335933849215508, -0.0013776093255728483, 0.027286021038889885, -0.02249850519001484, -0.013492826372385025, 0.00961577333509922, 0.009110743179917336, -0.004289478063583374, 0.005490167066454887, 0.003699813736602664, -0.01996396854519844, -0.01627681776881218, 0.003582043806090951, -0.00911317951977253, -0.035746775567531586, 0.005799856968224049, 0.0025701443664729595, 0.01020692940801382, 0.010236145928502083, 0.0021262215450406075, 0.007494228892028332, -0.007472297642379999, 0.06637462228536606, -0.02039451152086258, 0.015324500389397144, -0.004192314110696316, -0.012216760776937008, -0.009579690173268318, -0.009593656286597252, -0.01161649264395237, -0.006488643120974302, -0.00248192111030221, -0.012015949934720993, -0.00805620662868023, -0.02121397852897644, -0.01884273998439312, -0.0014951382763683796, -0.03998826816678047, 0.002374052070081234, 0.01681719906628132, 0.0023042913526296616, 0.009250245988368988, -0.0026838318444788456, 0.020636070519685745, -0.017159804701805115, 0.008333354257047176, 0.015088438056409359, 0.04035239666700363, 0.010372449643909931, 0.0234408937394619, -0.03154988959431648, 0.012051867321133614, 0.01676122471690178, 0.01630989834666252, 0.023949505761265755, 0.0003419974818825722, 0.002027023583650589, 0.000798987690359354, -0.004139128606766462, -0.021316727623343468, -0.010987259447574615, -0.0018181554041802883, -0.015210529789328575, -0.004362808540463448, 0.0095139741897583, 0.01946357637643814, -0.01146719604730606, 0.015036940574645996, -0.005244462285190821, -0.0053866864182055, 0.01389162428677082, 0.019391143694519997, 0.011998116970062256, -0.0007137299980968237, -0.00987993087619543, -0.009758350439369678, 0.03464833274483681, 0.0020158695988357067, -0.0013771476224064827, 0.011915316805243492, -0.010036297142505646, 0.006146337371319532, -0.005215832497924566, 0.005358876660466194, -0.012990081682801247, -0.005724758841097355, -0.0007034414447844028, 0.02101687528192997, 0.025729529559612274, -0.021852079778909683, 0.013234570622444153, 0.037355195730924606, 0.0008437954820692539, 0.005886327475309372, 0.011595245450735092, -0.0030732275918126106, -0.010301169939339161, -0.020889051258563995, -0.01269040908664465, 0.009415905922651291, 0.008719099685549736, 0.024587538093328476, 0.020208748057484627, -0.0025577854830771685, 0.005287874955683947, -0.01827828213572502, 0.03403142839670181, 0.012209910899400711, 0.027031540870666504, -0.011706162244081497, 0.01184016652405262, -0.010901141911745071, -0.009326942265033722, 0.004354238975793123, -0.003177088685333729, 0.002343039959669113, -0.0812930166721344, -0.011863515712320805, 0.02182452380657196, -0.027261434122920036, 0.006754247471690178, -0.008574232459068298, -0.0059724235907197, 0.018479419872164726, -0.011904872953891754, -0.0005506458692252636, 0.031234854832291603, 0.01955782063305378, -0.008020004257559776, -0.023787330836057663, 0.006829830817878246, -0.007803519256412983, 0.012722067534923553, 0.021951135247945786, 0.012156056240200996, -0.019771050661802292, 0.00997124332934618, -0.01519736833870411, -0.029263736680150032, 0.01660025678575039, 0.009582484140992165, -0.014358991757035255, 0.02076677419245243, 0.008188995532691479, -0.015492464415729046, 0.006763639859855175, -0.0007441933266818523, -0.016219671815633774, 0.028800681233406067, 0.00012363959103822708, 0.0037142171058803797, 0.01236896775662899, 0.011394985020160675, 0.017885247245430946, -0.011839590035378933, 0.033938247710466385, 0.005811840761452913, 0.023011498153209686, 0.00855228304862976, 0.0037031560204923153, 0.022418465465307236, 0.0008902373956516385, 0.030760958790779114, -0.004026318434625864, 0.010974422097206116, 0.002427868777886033, 0.02332824282348156, -0.002586844377219677, 0.007523384876549244, 0.023215577006340027, -0.016349313780665398, 0.003601344535127282, -0.007529241964221001, -0.01333324983716011, -0.010547645390033722, -0.012132980860769749, -0.0025462221819907427, -0.010974874719977379, -0.008858942426741123, 0.00009431596845388412, -0.01952211931347847, 0.003245115280151367, 0.007397886831313372, 0.00716430926695466, -0.01073835976421833, -0.008438536897301674, 0.018006350845098495, 0.009725167416036129, -0.0039980411529541016, -0.0006861003348603845, -0.03435760736465454, -0.007972333580255508, -0.01399887353181839, -0.0021175346337258816, 0.007031082175672054, 0.004794454202055931, -0.025927135720849037, -0.011101802811026573, -0.027756385505199432, -0.020160432904958725, -0.028437789529561996, -0.03825266659259796, 0.002714131958782673, 0.020040152594447136, 0.013658405281603336, -0.014370119199156761, 0.0037231305614113808, -0.007878879085183144, -0.0046995654702186584, 0.008958949707448483, -0.007448190823197365, 0.002179806586354971, 0.016117338091135025, 0.011094323359429836, 0.029521500691771507, 0.007202628068625927, -0.027413956820964813, -0.003550274996086955, -0.004106489941477776, -0.010449625551700592, 0.006032904610037804, 0.012873472645878792, -0.0038426308892667294, -0.008143286220729351, -0.011156483553349972, -0.003574019530788064, -0.011845551431179047, 0.0007873661816120148, -0.002914842450991273, 0.0485810860991478, 0.014123992994427681, 0.0048499396070837975, -0.007195126265287399, -0.0296983290463686, 0.07263118773698807, -0.012214366346597672, -0.0053518000058829784, 0.0013966981787234545, 0.008957110345363617, 0.002948440844193101, 0.005131338723003864, 0.023764975368976593, -0.007415917702019215, 0.012808228842914104, 0.011994073167443275, 0.0024568692315369844, 0.018043089658021927, 0.01862926036119461, -0.016559414565563202, -0.0059420387260615826, 0.012489695101976395, 0.006020418368279934, 0.00281042349524796, 0.036739371716976166, -0.005709836725145578, -0.021379966288805008, -0.021314304322004318, 0.013828756287693977, -0.020130354911088943, -0.004094848874956369, 0.032452840358018875, -0.018039245158433914, -0.007298626936972141, 0.0007116440683603287, -0.0005925833247601986, -0.0032896697521209717, -0.008659740909934044, 0.0064783766865730286, 0.031479038298130035, -0.00845278985798359, -0.01386521477252245, -0.003678229171782732, -0.0018843018915504217, -0.010225632227957249, 0.004785524681210518, -0.010460002347826958, 0.012925617396831512, 0.014929800294339657, 0.01794484257698059, 0.013059252873063087, 0.03902969881892204, -0.008463090285658836, 0.0103205107152462, -0.021765466779470444, -0.012995407916605473, 0.010542578063905239, 0.013946034014225006, 0.00045941665302962065, -0.015100973658263683, -0.001734007615596056, 0.01332133263349533, -0.0067665609531104565, -0.013923813588917255, 0.0066708833910524845, -0.023333005607128143, 0.0021910732612013817, -0.022752108052372932, 0.0033066135365515947, 0.010437225922942162, -0.021827606484293938, -0.010776055976748466, -0.006116163916885853, 0.005684210918843746, 0.018121980130672455, 0.013407845050096512, -0.02567129209637642, -0.0009817618411034346, 0.0075711822137236595, 0.0021806061267852783, 0.0013025165535509586, 0.004098063800483942, -0.005499336868524551, 0.007583185099065304, 0.01709624007344246, -0.013140839524567127, 0.0013234447687864304, 0.016874292865395546, 0.02103252336382866, 0.02844838984310627, 0.010132077150046825, -0.0253570806235075, -0.0748591274023056, -0.019803166389465332, 0.0064699966460466385, -0.004367121495306492, -0.013029920868575573, -0.014577045105397701, -0.023190200328826904, -0.020254315808415413, -0.017667246982455254, 0.003325125202536583, 0.01303480751812458, -0.002107890322804451, -0.00809846818447113, 0.011854558251798153, 0.0108727365732193, -0.015050780028104782, 0.0005818002391606569, -0.008444404229521751, 0.00010286131873726845, -0.008958582766354084, -0.00024199672043323517, 0.022482749074697495, -0.004258457571268082, 0.009262376464903355, -0.002855657832697034, -0.08117248862981796, -0.021134138107299805, 0.0051834192126989365, 0.005786072928458452, -0.0024598012678325176, 0.020503919571638107, -0.01800358295440674, 0.006463509518653154, 0.01612744852900505, -0.015801480039954185, 0.02289763279259205, 0.023657463490962982, 0.0043965610675513744, -0.012933877296745777, -0.016315506771206856, -0.009707510471343994, 0.003834731411188841, -0.01692187413573265, -0.023287270218133926, 0.003037621732801199, 0.012334130704402924, -0.004826854914426804, -0.011987096630036831, -0.005335723981261253, -0.012732957489788532, 0.024375872686505318, -0.0014580369461327791, 0.018497563898563385, 0.00416474137455225, 0.023348869755864143, -0.006448138505220413, 0.01346819568425417, 0.010757040232419968, -0.017336923629045486, 0.013444113545119762, -0.007889751344919205, 0.016821788623929024, 0.008132844232022762, -0.009310162626206875, -0.013870051130652428, -0.0029771216213703156, 0.03277670592069626, -0.02791101112961769, -0.0005196718266233802, -0.025840166956186295, 0.04076787456870079, 0.005575838498771191, -0.0076171294786036015, 0.0026348517276346684, -0.025059601292014122, 0.005952498875558376, -0.050233714282512665, 0.008470026776194572, -0.00926670990884304, 0.01572832092642784, -0.009272860363125801, -0.0033307913690805435, 0.022379036992788315, 0.030975325033068657, -0.009340034797787666, -0.007359475828707218, 0.025191262364387512, 0.0018451292999088764, 0.07145263254642487, -0.0008539697155356407, 0.021397802978754044, 0.008094160817563534, -0.008419474586844444, 0.003342114854604006, -0.015400412492454052, -0.031272705644369125, -0.0017240007873624563, -0.00495815509930253, 0.005388134159147739, -0.009558753110468388, 0.005616642534732819, 0.010230150073766708, -0.019082697108387947, 0.00013941433280706406, -0.004492756444960833, 0.003245882224291563, 0.0029402081854641438, 0.01409971248358488, 0.00222301809117198, 0.009901579469442368, 0.00676561426371336, -0.0007983539253473282, 0.019901098683476448, 0.0036782692186534405, -0.005048530641943216, 0.00946803018450737, -0.016032448038458824, -0.013709132559597492, 0.0042723724618554115, 0.007221666164696217, -0.0009594740113243461, 0.007930023595690727, 0.013882995583117008, 0.012437690049409866, -0.006002499256283045, 0.00204165349714458, -0.010080746375024319, -0.0075305150821805, 0.01480061374604702, -0.01487253699451685, -0.002046844456344843, 0.008053974248468876, -0.030575459823012352, -0.007792910560965538, 0.003650425001978874, -0.006063127890229225, -0.0007505696266889572, 0.001711393939331174, 0.009883646853268147, 0.0017818976193666458, 0.018062632530927658, -0.023438557982444763, 0.018360191956162453, 0.0015261631924659014, -0.01961759850382805, 0.022280124947428703, -0.00695628859102726, -0.016314389184117317, -0.016828645020723343, -0.022614261135458946, -0.018919602036476135, -0.017703279852867126, 0.009593497030436993, 0.0014044595882296562, 0.02181960828602314, -0.007092424668371677, 0.013407138176262379, 0.016840308904647827, 0.0013958100462332368, -0.01676863804459572, 0.006312391255050898, 0.0013881644699722528, 0.018264802172780037, 0.00038908515125513077, -0.00947078038007021, -0.02206495963037014, 0.023120885714888573, 0.0012841300340369344, -0.0231091920286417, 0.0136563116684556, 0.0321422778069973, -0.021101325750350952, 0.007713534403592348, 0.021891936659812927, -0.010088306851685047, -0.00954138208180666, -0.0057889549061656, 0.015624303370714188, -0.0031152917072176933, -0.009673476219177246, -0.0023942207917571068, 0.013344448059797287, 0.006683272309601307, 0.03367965295910835, -0.015815697610378265, 0.011653891764581203, 0.00800330936908722, -0.0006313775666058064, 0.04535550996661186, -0.009835154749453068, -0.006732346955686808, -0.016264809295535088, -0.0022538069169968367, -0.012633560225367546, 0.004670645575970411, -0.008069898933172226, 0.009292049333453178, 0.039464548230171204, 0.0011448133736848831, 0.008424418047070503, -0.0014095590449869633, -0.010866666212677956, 0.003927226178348064, 0.0349474772810936, -0.011114352382719517, 0.004235274624079466, -0.015583966858685017, -0.009595521725714207, 0.01428296696394682, -0.018478181213140488, -0.005180906504392624, 0.004694806411862373, 0.007135097403079271, -0.01859365962445736, -0.013326638378202915, 0.007549104746431112, -0.006762600038200617, -0.01805153675377369, 0.012163056060671806, -0.014128897339105606, -0.016061939299106598, -0.00662366533651948, 0.0028772649820894003, -0.01659698784351349, 0.0016128860879689455, -0.006879705935716629, -0.003854675218462944, 0.005992473568767309, 0.02562076970934868, -0.010643969289958477, -0.0025283931754529476, 0.008394776843488216, 0.009914970025420189, 0.006629333831369877, -0.013111328706145287, 0.0043698567897081375, 0.0064947279170155525, 0.021701203659176826, 0.02586028166115284, 0.012690383940935135, -0.004742135759443045, -0.005219854414463043, -0.028293170034885406, 0.02077776938676834, 0.015222707763314247, -0.025541391223669052, -0.018348202109336853, -0.0124648567289114, -0.011070058681070805, 0.0013554098550230265, 0.016830135136842728, 0.006161170545965433, 0.0021031752694398165, -0.02831367217004299, 0.014016333036124706, 0.0039109219796955585, -0.0073399473913013935, -0.009002666920423508, -0.014195329509675503, -0.021727487444877625, -0.004342593718320131, 0.013385705649852753, -0.0009541439358144999, -0.004158016759902239, 0.004225393291562796, 0.001933000748977065, 0.02924821339547634, 0.010842222720384598, -0.007783716544508934, 0.006357044912874699, -0.005205120425671339, -0.003071273909881711, 0.0074154287576675415, 0.013103732839226723, -0.008885199204087257, 0.007785782217979431, 0.011691209860146046, -0.004077249672263861, -0.0033963259775191545, -0.0047337934374809265, -0.015931682661175728, 0.002978572389110923, -0.019854681566357613, -0.00845035444945097, 0.007687190547585487, -0.03849846497178078, 0.020760346204042435, 0.011929372325539589, 0.0053559341467916965, -0.0013380442978814244 ]
[ -0.21781747043132782, 0.16573014855384827, 0.005864804610610008, -0.19317080080509186, 0.33059585094451904, 0.13303117454051971, 0.08645439893007278, 0.022493550553917885, -0.24643170833587646, -0.6863479018211365, -0.05960335582494736, -0.06818842887878418, -0.1715383380651474, 0.15038888156414032, -0.3994647264480591, 0.4835728108882904, -0.1293463259935379, 0.3374834656715393, -0.6703851819038391, -0.8433506488800049, 0.21958424150943756, -0.030915990471839905, 0.45977771282196045, 0.45700111985206604, 0.28811246156692505, -0.004321997985243797, 0.2535286545753479, -0.2031366229057312, 0.22586095333099365, -0.34762299060821533, -0.38519909977912903, 0.3254169523715973, 0.018273256719112396, 0.20427632331848145, -0.2985982596874237, -0.23707923293113708, -0.5053419470787048, -0.5068959593772888, 0.036414701491594315, 0.18024645745754242, -0.019100680947303772, -0.23027180135250092, -0.16618041694164276, 0.5258999466896057, -0.04661459103226662, 0.04534228518605232, -1.5006831884384155, 0.9811996817588806, -0.13286027312278748, 0.19535580277442932, -0.3415312170982361, 0.19318214058876038, 0.39936771988868713, 0.3878686726093292, 0.37409234046936035, -0.03694481402635574, -0.5451128482818604, 0.124909907579422, 0.4801221787929535, -0.5468336343765259, -0.2832176387310028, 0.1832466870546341, -0.4027700424194336, 0.34895870089530945, 0.5859484076499939, 0.47972771525382996, 0.22259195148944855, -0.549145519733429, -0.7019584774971008, -0.2888989746570587, -0.06771252304315567, -0.5838389992713928, -0.08085913956165314, 0.4463091790676117, -0.1072770208120346, -0.21228136122226715, -0.541864812374115, -0.4297142028808594, 0.06891476362943649, 0.03859112411737442, -0.484543114900589, 0.0671439915895462, 0.2025999277830124, -0.0639500543475151, 0.5448613166809082, -0.37835702300071716, -0.7045909762382507, 0.3956311047077179, -0.4078202247619629, 0.10900259017944336, -0.14551739394664764, -0.31143614649772644, 0.5258020162582397, 0.33755970001220703, 0.0646040216088295, 0.7368788123130798, 0.29546990990638733, 0.23684197664260864, 0.11377298086881638, 0.08286642283201218, 0.05555490031838417, 0.16045214235782623, 0.3843490481376648, -0.3732105493545532, -0.40760061144828796, -0.7863783836364746, 0.05118405073881149, -0.5682980418205261, -0.10947729647159576, -0.17648792266845703, -0.5272451639175415, -0.1875881403684616, -0.2434675544500351, -0.15294085443019867, 0.2980572283267975, -0.011919745244085789, -0.15475894510746002, -0.7485438585281372, 0.2042325884103775, 0.07573364675045013, -0.07713937014341354, 0.9598807096481323, -0.09992867708206177, 0.6402732729911804, -0.0018346270080655813, -0.14406950771808624, 0.21603241562843323, -0.09988678246736526, -0.5080201029777527, 0.3527766764163971, 0.1279338002204895, 1.0729115009307861, -0.07690319418907166, 0.096070297062397, -0.06726159900426865, 0.05749490484595299, 0.2229069322347641, 0.2878899872303009, 0.5883968472480774, -0.17403912544250488, -0.6571614742279053, -0.4691770672798157, -0.16238637268543243, 0.03186299279332161, -0.091281957924366, -0.4997003972530365, 0.012867221608757973, -0.40745869278907776, 0.32451558113098145, -0.4597753882408142, 0.23746371269226074, -0.321197509765625, -0.9040353298187256, -0.5838884711265564, -0.004998671822249889, 0.2743595242500305, 0.1773245930671692, -0.00036833577905781567, -0.0009411081555299461, 0.2258969098329544, -0.12338776141405106, -0.338528037071228, -0.2686156630516052, -0.04963631182909012, 0.19946710765361786, 0.04794270545244217, 0.9022905826568604, 0.2953975200653076, -0.012648881413042545, -0.25148648023605347, -0.3690510094165802, -0.31027477979660034, 0.37194889783859253, -0.44858065247535706, -0.412176251411438, -0.06663637608289719, 0.15324440598487854, 0.0003720694803632796, 0.06781795620918274, -0.06067618727684021, -0.442863404750824, -0.12932957708835602, -0.09012418240308762, 0.05274539440870285, 0.6422318816184998, -0.0017567136092111468, 0.2974250316619873, -0.17853115499019623, -0.683124840259552, 0.026579994708299637, 0.21610404551029205, -0.23570595681667328, 0.7226086258888245, -0.48677346110343933, 0.9291507601737976, -0.18966032564640045, -0.350612610578537, 0.7696908116340637, 0.19535787403583527, -0.3757724463939667, -0.7259254455566406, 0.30570292472839355, 0.7061935067176819, -0.34546875953674316, -0.1659017950296402, 0.47507983446121216, 0.06167687848210335, -0.16600535809993744, 0.19963867962360382, 0.3094526529312134, -0.1859874278306961, -0.48089540004730225, 0.12730087339878082, -0.15126164257526398, 0.3424408435821533, -0.05769343674182892, -0.1688607782125473, -0.33513376116752625, -0.5619432330131531, 0.14451074600219727, 0.13308842480182648, -0.5073010921478271, 0.7244489192962646, 0.7583143711090088, -0.19215898215770721, 0.30256691575050354, 0.6287403106689453, 0.7920289635658264, 0.6852776408195496, 0.11572578549385071, 0.4650484323501587, -0.6653510928153992, 0.2027386575937271, 0.12081123888492584, -0.02115989290177822, 0.2428005188703537, 0.19075480103492737, -0.3443336486816406, -0.3407130241394043, 0.06061134859919548, -0.2816370129585266, 0.5753756761550903, -0.6637943983078003, -0.03971501812338829, -0.06753388792276382, -0.19215644896030426, -0.12208707630634308, -0.19499069452285767, -0.7635496258735657, 0.2920961380004883, 0.3526710271835327, 0.15004132688045502, 0.2096935212612152, -0.6614009141921997, -0.3154682517051697, -0.42299649119377136, 0.20940732955932617, -0.1523819863796234, 0.5592486262321472, -0.6237733364105225, 0.3923457860946655, -0.7318193316459656, 0.2125585675239563, -0.15505678951740265, -0.25803235173225403, -0.31721463799476624, -0.7780675888061523, -0.0601586289703846, 1.2378120422363281, 0.7267071604728699, 0.8737714886665344, 0.1580737978219986, -0.6204143166542053, -0.07581620663404465, 0.13610957562923431, -0.2784086763858795, -0.2853720486164093, 0.1520591527223587, -0.1579950600862503, -0.00643762294203043, -0.21514514088630676, -0.2843559682369232, 0.5437189340591431, 0.05774938687682152, -0.33939042687416077, 0.38333889842033386, 0.1311737447977066, -0.21584883332252502, -0.1356821209192276, -0.5262904167175293, -0.26098954677581787, 0.31768354773521423, -0.0507173016667366, 0.11408598721027374, 0.5933687686920166, 0.3469874858856201, -0.132770374417305, 0.07897691428661346, 0.6040209531784058, -0.3625509738922119, 0.06815588474273682, 0.13633114099502563, -0.2293083667755127, -0.07938264310359955, -0.20566412806510925, 0.21439442038536072, -0.3467421531677246, 0.3079428970813751, -5.874936580657959, -0.02312491647899151, -0.36049047112464905, -0.22832626104354858, -0.10401929914951324, -0.18913212418556213, 0.7019078731536865, 0.2773473262786865, 0.2777494490146637, 0.18821953237056732, 0.12054865807294846, -0.07864822447299957, 0.29110702872276306, -0.08637821674346924, -0.23410393297672272, -0.14108338952064514, -0.013744428753852844, -0.400119811296463, 0.43362337350845337, -0.014845529571175575, 0.09920097142457962, -0.4665703773498535, 0.04703943431377411, 0.15789911150932312, -0.34013283252716064, -0.21846038103103638, -0.3076600134372711, -0.26130953431129456, -0.03396329656243324, -0.7469034790992737, -0.3575828969478607, -0.5236436128616333, -0.26384127140045166, -0.16290020942687988, 0.6662920713424683, -0.10821995884180069, 0.2654080092906952, -0.05738118663430214, 0.47254061698913574, -0.16628867387771606, 0.7747423052787781, 0.41279059648513794, 0.23181498050689697, -0.1195358857512474, 0.44853800535202026, -0.012844272889196873, -0.18002958595752716, 0.2529655992984772, -0.4369039833545685, 0.8025754690170288, -0.10174690932035446, -0.10125703364610672, 0.2551097571849823, 0.1042105033993721, 0.5981877446174622, 0.05248580500483513, -0.3299228847026825, -0.5537949800491333, -0.6701568365097046, 0.1777610033750534, -0.14591871201992035, -0.38019976019859314, 0.10475892573595047, -0.6807104349136353, 0.01651342399418354, 0.48937731981277466, -1.0562466382980347, -0.5283547639846802, 0.14924556016921997, -0.3135018050670624, 0.1690375953912735, 0.336595356464386, 0.34201693534851074, -0.4355514347553253, 0.4120357036590576, 0.037340305745601654, 0.027222340926527977, 0.5665143728256226, -0.22274819016456604, -0.11187402904033661, -0.3383217453956604, -0.012798485346138477, 0.10987740755081177, -0.19143424928188324, -0.13530577719211578, -0.010959445498883724, -0.31708982586860657, 0.12626434862613678, -0.6328524351119995, 0.4535931944847107, 0.4938267171382904, -0.2572406828403473, -0.08844684064388275, 0.525378942489624, 0.09357859939336777, -0.03820125013589859, -0.07159458845853806, 0.45759639143943787, 0.8289510011672974, 0.07876485586166382, 0.7565836906433105, -0.05886814743280411, -0.2428743839263916, -0.32622936367988586, -0.40860992670059204, 0.4302574694156647, -0.26115208864212036, 0.5390110015869141, 0.5677568316459656, -0.6917273998260498, -0.17691664397716522, -0.101420558989048, -0.47849249839782715, -0.4089158773422241, 0.3116956949234009, -0.3167691230773926, -0.34589582681655884, 0.2249288409948349, 0.8739046454429626, -0.13577893376350403, -0.1778213381767273, 0.03434215113520622, -0.675649106502533, 0.20060807466506958, 0.254669725894928, -0.37051329016685486, -0.007697698660194874, 0.6404820084571838, -0.3975594937801361, 0.12738636136054993, 0.11236697435379028, 0.8497897386550903, 0.10006304085254669, 0.017821917310357094, 0.034323640167713165, -0.0564916618168354, -0.4952475428581238, 0.6211712956428528, 0.11105196177959442, -0.248879075050354, 0.5822629332542419, -0.13759101927280426, 0.2205500304698944, -0.5284003019332886, 0.3737308382987976, 0.29435133934020996, -0.5104121565818787, 0.11266427487134933, -0.4733079671859741, -0.2648846209049225, -0.07895954698324203, -0.5238960981369019, 0.26155927777290344, 0.09291709959506989, -0.10275774449110031, 0.2023923695087433, 0.1261603683233261, 0.4451633393764496, 0.32691434025764465, -0.5662261843681335, -0.11405079811811447, -0.3986002206802368, -0.2926595211029053, 0.30226919054985046, -0.47020432353019714, 0.4134439527988434, -0.0970359668135643, -0.7343508005142212, -0.29946157336235046, 0.5631845593452454, -0.4775468707084656, 0.28304409980773926, -0.294777512550354, -0.3924955725669861, -0.05117199569940567, -0.18976490199565887, -0.26158711314201355, -0.04312478005886078, 0.047308921813964844, -0.2322002500295639, -0.18791820108890533, -0.3389289975166321, -0.053664207458496094, 0.5410655736923218, -0.3427472710609436, 0.2233644276857376, 0.3032550811767578, 0.13958927989006042, -0.30876991152763367, -0.483065128326416, -0.06019650027155876, -0.14565351605415344, 0.008178399875760078, -0.41331174969673157, 0.09815289080142975, 0.3501531481742859, 0.39261364936828613, 0.3498243987560272, -0.45671430230140686, -0.6067655682563782, 0.45700860023498535, 0.2510404586791992, -0.646665632724762, 0.05843426287174225, 0.6166490316390991, -0.027492797002196312, -0.35522910952568054, 0.10424108803272247, -0.20986591279506683, -0.2320985645055771, -0.38595113158226013, -0.42725566029548645, 0.28453031182289124, 0.37535080313682556, 0.2691516578197479, -0.41805213689804077, 0.4576234519481659, 0.045992664992809296, -0.46087175607681274, 0.29246431589126587, 0.3068169057369232, 0.3276734948158264, 0.05949947610497475, 0.04567369818687439, -0.3152880072593689, 0.2913176119327545, 0.43366360664367676, -0.3955132067203522, 0.04924574866890907, 0.548880398273468, -0.06719304621219635, -0.12952187657356262, -0.18304261565208435, 0.0019458277383819222, 0.17740967869758606, -0.759807825088501, -0.07286019623279572, 0.21219933032989502, -0.366643488407135, 0.5841583013534546, 0.7378302812576294, 0.6844899654388428, -0.05165015161037445, 0.054746076464653015, 0.10534452646970749, 0.24954411387443542, 0.3245373070240021, -0.9270280003547668, -0.49577596783638, 0.4636977016925812, 0.712327241897583, -0.2922472655773163, 0.15281467139720917, 0.5462790131568909, 0.7382012009620667, 0.02276770956814289, -0.3997141122817993, -0.09177302569150925, 0.0029248076025396585, 0.48080188035964966, -0.15382851660251617, 0.12990200519561768, 0.15416723489761353, 0.021742861717939377, 0.36866167187690735, 0.10279049724340439, -0.3714025616645813, -0.2602219879627228, 0.37405925989151, -0.12121391296386719, 0.3782307803630829, -0.3952215909957886, 0.6494483947753906, -0.16997621953487396, 0.12132283300161362, 0.45291465520858765, -0.40011170506477356, 0.4100086987018585, 0.26372087001800537, -0.04045486077666283, -0.27675217390060425, -0.4570487141609192, 0.3253498375415802, -0.5365806221961975, 0.5539612174034119, -0.6530227065086365, -0.15033705532550812, -0.28580352663993835, 0.3006911873817444, 0.2659660279750824, -0.2694758474826813, -0.19131581485271454, -0.5186398029327393, 0.011689089238643646, 0.19149664044380188, -0.014297031797468662, 0.1667678952217102, 0.6639514565467834, 0.06240458786487579, 0.2754945158958435, -0.418587863445282, 0.43794772028923035, 0.06523451954126358, -0.6040151715278625, -0.4727942943572998, 0.2356743961572647, -0.009740361012518406, 0.14486980438232422, -0.6942706108093262, -0.11149873584508896, 0.19782957434654236, -0.09284274280071259, 0.13887754082679749, 0.015213648788630962, -0.24376749992370605, 0.3260335922241211, 0.11236675083637238, -0.1217387393116951, 0.0960511639714241, 0.3134019672870636, 0.39296260476112366, 0.8091151714324951, 0.26833173632621765, -0.17400196194648743, -0.02866571769118309, 0.3613368272781372, 0.32267364859580994, 0.3543531894683838, -0.03837777301669121, 0.6942707896232605, 0.49138525128364563, 0.045089613646268845, 0.09939007461071014, 0.5423955321311951, 0.5146211385726929, 0.04512383043766022, -0.08246570080518723, -0.9042615294456482, 0.1992945373058319, 0.2871434688568115, 0.4808761179447174, 0.8944264650344849, -0.5877365469932556, -0.1489589661359787, 0.7482067942619324, 0.08574149757623672, 0.05536925792694092, -0.21774479746818542, -0.041416071355342865, 0.8707232475280762, 0.1479155421257019, -0.9089981317520142, -0.5369897484779358, 0.21467968821525574, -0.9129818677902222, -0.12535706162452698, 0.42186033725738525, -0.00033488182816654444, -0.41756579279899597, 0.26786190271377563, -0.6113302111625671, 0.2900572419166565, -0.09424196928739548, 0.28310680389404297, -0.0034307397436350584, -0.18107831478118896, 0.5322632193565369, -0.14741410315036774, 0.26353204250335693, -0.2013954371213913, 0.09770873188972473, 0.28309839963912964, -0.18061865866184235, -0.30899763107299805, 0.32754290103912354, -0.5272683501243591, 0.3427199721336365, -0.09015628695487976, -0.3007347881793976, 0.6457273960113525, -0.053495798259973526, 0.3626737892627716, 0.011067835614085197, -0.7128873467445374, -0.703682541847229, -0.4712618589401245, 0.01848198100924492, -0.2590404450893402, 0.42958393692970276, 0.15573124587535858, 0.5019536018371582, -0.5730079412460327, -0.05244595184922218, -0.1202886626124382, -0.11262858659029007, -0.06402913480997086, -0.3419206738471985, 0.2597202956676483, 0.7187680602073669, 0.25775444507598877, 0.03616068512201309, 0.1513047069311142, -0.1419314295053482, -0.0649099051952362, -0.32454147934913635, 0.6222816109657288, -0.16544990241527557, -0.6251084208488464, -0.20170748233795166, -0.038766659796237946, 1.4051427841186523, 0.44219616055488586, -0.5411652326583862, 0.40999388694763184, 0.3816986680030823, 0.45331814885139465, 0.4124477505683899, -0.797255277633667, -0.2020954191684723, -0.7803159356117249, 0.14109519124031067, -0.37313181161880493, 0.3327880799770355, 0.21129009127616882, 0.06390350311994553, 0.1326756477355957, 0.7500984072685242, 0.23183968663215637, -0.15560197830200195, 0.5803914666175842, -0.3244081735610962, 0.21562226116657257, -0.5289738774299622, 0.19249525666236877, -0.26778414845466614, 0.29075348377227783, -0.4855225086212158, 0.06712756305932999, 0.3391604423522949, -0.5917239189147949, 0.04948214441537857, -0.04046017304062843, -0.6299951076507568, 0.000595063145738095, -0.11729485541582108, -0.020455187186598778, -0.32939115166664124, -0.770707905292511, -0.5630120038986206, 0.1816868633031845, 0.48229604959487915, -0.2563237249851227, -0.04340386018157005, 0.5847916007041931, 0.1636500507593155, -0.6527028679847717, 0.060671474784612656, -0.6313776969909668, 0.07976382970809937, 0.14306992292404175 ]
BMI-1 is overexpressed in a variety of cancers, which can elicit an immune response leading to the induction of autoantibodies. However, BMI-1 autoantibody as a biomarker has seldom been studied with the exception of nasopharyngeal carcinoma. Whether BMI-1 autoantibodies can be used as a biomarker for cervical carcinoma is unclear. In this study,BMI-1 proteins were isolated by screening of a T7 phage cDNA library from mixed cervical carcinoma tissues. We analyzed BMI-1 autoantibody levels in serum samples from 67 patients with cervical carcinoma and 65 controls using ELISA and immunoblot. BMI-1 mRNA or protein levels were over-expressed in cervical carcinoma cell lines. Immunoblot results exhibited increased BMI-1 autoantibody levels in patient sera compared to normal sera. Additionally, the results for antibody affinity assay showed that there was no difference between cervical polyps and normal sera of BMI-1 autoantibody levels, but it was significantly greater in patient sera than that in normal controls (patient 0.827±0.043 and normal 0.445±0.023; P<0.001). What's more, the levels of BMI-1 autoantibody increased significantly at stage I (0.672±0.019) compared to normal sera (P<0.001), and levels of BMI-1 autoantibodies were increased gradually during the tumor progression (stage I 0.672±0.019; stage II 0.775 ±0.019; stage III 0.890 ±0.027; stage IV 1.043±0.041), which were significantly correlated with disease progression of cervical cancer (P<0.001). Statistical analyses using logistic regression and receiver operating characteristics (ROC) curves indicated that the BMI-1 autoantibody level can be used as a biomarker for cervical carcinoma (sensitivity 0.78 and specificity 0.76; AUC = 0.922). In conclusion, measuring BMI-1 autoantibody levels of patients with cervical cancer could have clinical prognostic value as well as a non-tissue specific biomarker for neoplasms expressing BMI-1.
[ 0.006607450544834137, 0.012745853513479233, -0.009880471974611282, 0.02682408131659031, 0.007097506895661354, -0.0077653322368860245, 0.011494170874357224, -0.011327050626277924, -0.01421687938272953, -0.00700253015384078, -0.022903654724359512, 0.014508538879454136, -0.010112201794981956, 0.009394734166562557, -0.01380221452564001, -0.018084198236465454, -0.03388671576976776, 0.008488783612847328, 0.005049147177487612, 0.05346590653061867, -0.0012197024188935757, 0.005906484089791775, 0.010388670489192009, 0.005268160253763199, 0.04284495487809181, 0.01320748869329691, -0.01932489313185215, -0.027116455137729645, -0.018871279433369637, 0.009054828435182571, -0.0021986966021358967, -0.02319703809916973, 0.01356399618089199, -0.03280218318104744, -0.005125690251588821, -0.007131726481020451, -0.00600020494312048, 0.01835538260638714, -0.03180769085884094, -0.0045059192925691605, -0.00672109704464674, -0.01024777814745903, 0.00014041690155863762, -0.01872212439775467, -0.006876800209283829, -0.011021462269127369, 0.0032242885790765285, 0.019981542602181435, -0.0038926824927330017, 0.007635866291821003, -0.014432186260819435, -0.007330338004976511, -0.009206045418977737, 0.002571149729192257, -0.006610323674976826, 0.032217659056186676, 0.01924699731171131, -0.008183524943888187, -0.05210709571838379, 0.027579868212342262, 0.01834004372358322, -0.026342246681451797, 0.007182166446000338, -0.007862277328968048, -0.028083205223083496, -0.06702897697687149, 0.00993418414145708, -0.02415328472852707, 0.0029008276760578156, -0.004719216376543045, -0.004096599295735359, 0.011245934292674065, -0.0017139352858066559, -0.006872512400150299, 0.01092623732984066, -0.01423115748912096, -0.011201754212379456, -0.017181281000375748, 0.027312032878398895, -0.008182474412024021, -0.00015452271327376366, 0.006465563550591469, -0.01287734042853117, 0.02171040140092373, 0.002595999976620078, 0.011013301089406013, -0.021852537989616394, 0.004037035629153252, 0.02763785608112812, 0.01937134377658367, 0.005964342504739761, 0.008773406967520714, -0.043287068605422974, -0.01596681959927082, 0.009655610658228397, 0.007302875630557537, -0.002053446602076292, 0.003944342490285635, 0.03326860070228577, 0.03345862030982971, -0.02020414173603058, -0.01422831416130066, 0.016264479607343674, -0.020154574885964394, -0.008682849816977978, 0.011776929721236229, -0.01883036643266678, -0.0173442792147398, -0.00439397944137454, 0.01509229838848114, -0.02100955694913864, 0.01143055409193039, 0.007933095097541809, -0.00790519081056118, -0.017566414549946785, -0.0014775716699659824, 0.007920779287815094, -0.03608359396457672, 0.0032521155662834644, 0.026108596473932266, -0.018196625635027885, -0.021096225827932358, 0.006619157735258341, 0.005485705099999905, -0.0007323623867705464, -0.012734007090330124, 0.025108881294727325, -0.00047464563976973295, 0.0005353924352675676, -0.013710031285881996, -0.007364978082478046, 0.0022824176121503115, -0.01632719300687313, 0.007399965077638626, 0.006938597187399864, 0.009378782473504543, -0.01541518047451973, 0.004725417587906122, -0.005471637472510338, -0.03130774572491646, 0.0011900218669325113, 0.008917278610169888, -0.005017352756112814, 0.016257865354418755, 0.014963842928409576, 0.0017164552118629217, -0.05813204124569893, -0.010003408417105675, 0.027030762284994125, -0.014607510529458523, -0.0005900545511394739, -0.004704912193119526, -0.006835024803876877, -0.024469200521707535, 0.021495087072253227, -0.013231849297881126, -0.005584729835391045, 0.02612273022532463, -0.011029522866010666, -0.012640465050935745, 0.004121807403862476, -0.015808822587132454, 0.012868303805589676, 0.009078091010451317, 0.025348497554659843, -0.015117079950869083, 0.029586125165224075, -0.010803301818668842, -0.0023428506683558226, 0.002654461422935128, -0.019727878272533417, -0.007772375829517841, 0.01019225548952818, 0.008650125935673714, -0.009625915437936783, 0.009441092610359192, 0.03027184307575226, 0.009298283606767654, -0.016364391893148422, 0.06691864132881165, 0.015186703763902187, -0.019628137350082397, 0.005657340865582228, 0.001791554968804121, 0.022298647090792656, -0.015129517763853073, 0.05078604817390442, -0.010891913436353207, -0.004018318373709917, -0.02026849053800106, -0.0076891290955245495, 0.021898942068219185, -0.004817374516278505, 0.023510854691267014, -0.0045222071930766106, 0.00392957916483283, 0.004027233459055424, 0.0042185066267848015, 0.025789296254515648, 0.0025210981257259846, -0.010940072126686573, -0.017657024785876274, 0.011283374391496181, 0.02387419529259205, -0.017031513154506683, 0.0027399773243814707, 0.02728389762341976, -0.01644241437315941, -0.03588486090302467, 0.011309800669550896, 0.029267940670251846, -0.010803512297570705, -0.008037319406867027, -0.007637754548341036, -0.0010410305112600327, -0.003818393452093005, 0.013059242628514767, 0.025530420243740082, -0.027034403756260872, -0.020751966163516045, -0.0029113239143043756, 0.01628333516418934, 0.0032797716557979584, -0.005229678004980087, -0.010625148192048073, -0.0035291695967316628, -0.002664727158844471, 0.01126322615891695, 0.01639399118721485, 0.01849851943552494, -0.012154348194599152, 0.01949775591492653, -0.012832991778850555, -0.003258545882999897, -0.013803206384181976, -0.030505523085594177, 0.01224953681230545, -0.03475544601678848, 0.004290516022592783, -0.0218192208558321, -0.004962535575032234, -0.018805304542183876, -0.018129823729395866, 0.009311631321907043, 0.03313164412975311, -0.00313209998421371, -0.008958615362644196, 0.026195993646979332, 0.020626218989491463, -0.009766879491508007, 0.005977780092507601, 0.0037239298690110445, 0.005540423095226288, 0.011858061887323856, -0.013218417763710022, -0.022968562319874763, -0.02925182320177555, 0.0059773861430585384, 0.025568556040525436, -0.03708149865269661, 0.003452165285125375, 0.002783747622743249, 0.02427956648170948, 0.005430130288004875, 0.010690025985240936, 0.030462343245744705, 0.006328660529106855, 0.022823715582489967, -0.018895361572504044, -0.0034568188712000847, 0.00875740684568882, -0.006378158461302519, -0.004683340899646282, -0.08120830357074738, -0.009094792418181896, -0.015006303787231445, -0.016649428755044937, 0.01014507282525301, 0.0014886879362165928, 0.02416810393333435, 0.022374551743268967, -0.008175423368811607, -0.02472791261970997, -0.0036751602310687304, 0.02790430746972561, -0.009336749091744423, 0.00794861651957035, -0.02878693677484989, -0.004776648245751858, 0.01579558104276657, -0.008867376483976841, -0.0044743092730641365, -0.006969161797314882, 0.03139291703701019, -0.012495497241616249, -0.003940749913454056, 0.012589400634169579, 0.025603249669075012, -0.0012537459842860699, -0.006570656783878803, -0.011589033529162407, 0.0007973581086844206, 0.004787715617567301, 0.01846003718674183, -0.0026408820413053036, 0.031594909727573395, -0.03405894339084625, 0.00858774222433567, -0.005944141186773777, -0.005767195485532284, 0.008145032450556755, -0.013113386929035187, 0.01103209424763918, -0.011045971885323524, 0.007979112677276134, 0.002282738219946623, -0.0018428191542625427, 0.020004436373710632, 0.005015153903514147, -0.023871198296546936, 0.049584243446588516, 0.00987942423671484, 0.0011995983077213168, 0.024316832423210144, 0.000792292645201087, 0.00394592946395278, 0.025110460817813873, -0.014609009027481079, -0.0065827034413814545, -0.0008602021262049675, -0.006378498859703541, -0.007371209096163511, -0.00203776266425848, -0.016511302441358566, 0.0017906571738421917, 0.029848521575331688, 0.013196701183915138, -0.014360842294991016, 0.02557441219687462, 0.00041212374344468117, 0.012877140194177628, -0.03324616700410843, 0.024415142834186554, 0.007711139041930437, -0.007070590741932392, 0.0002471674233675003, -0.012094096280634403, -0.01090115774422884, -0.005545113701373339, -0.01262447889894247, -0.02212730050086975, -0.020522043108940125, -0.0002811313606798649, -0.008383811451494694, 0.003906435798853636, -0.009938234463334084, 0.0027856947854161263, -0.013362165540456772, 0.017199436202645302, 0.00815240852534771, 0.03879672661423683, 0.002348541282117367, -0.010581327602267265, -0.015979889780282974, 0.03599219024181366, -0.015582036226987839, 0.01023382693529129, 0.020804330706596375, 0.00363400811329484, -0.013574093580245972, 0.01622125320136547, 0.022205129265785217, 0.008404519408941269, -0.012704802677035332, -0.0047157383523881435, 0.005584202241152525, -0.013262505643069744, -0.025882765650749207, 0.011974403634667397, -0.007017993368208408, 0.004789615049958229, -0.00813111662864685, -0.0061385296285152435, -0.02477516606450081, -0.011614618822932243, -0.013742954470217228, 0.03406795859336853, 0.006077764555811882, 0.04773560166358948, -0.009358495473861694, -0.012978194281458855, 0.07132259756326675, -0.011041756719350815, 0.0017548010218888521, -0.023400090634822845, 0.052598558366298676, -0.020147006958723068, -0.0298762209713459, -0.004418665077537298, -0.012105070054531097, 0.00849179644137621, 0.013653967529535294, 0.02872942015528679, 0.031819362193346024, 0.020686477422714233, 0.008335958234965801, 0.02538725733757019, 0.02016756683588028, -0.017028776928782463, 0.004496672656387091, -0.015693213790655136, -0.029215332120656967, 0.00483505055308342, -0.03588556498289108, -0.007711766287684441, 0.006224850192666054, -0.03441738709807396, 0.0116327665746212, -0.019569236785173416, -0.017886541783809662, 0.002470648381859064, 0.03168811649084091, -0.00473426841199398, -0.00668079499155283, -0.0036063194274902344, -0.0009719328954815865, -0.004941602703183889, -0.0033655045554041862, -0.010334006510674953, 0.020371735095977783, 0.004637905862182379, -0.011903363279998302, -0.012413054704666138, -0.002301737666130066, 0.0064349910244345665, -0.017420688644051552, -0.02144383266568184, 0.004840408451855183, -0.004647307097911835, 0.011489050462841988, -0.007483537308871746, 0.00028548017144203186, -0.0053330049850046635, 0.014054710045456886, -0.009558499790728092, 0.00046168151311576366, 0.011197468265891075, 0.027867505326867104, 0.0020668671932071447, -0.0036894844379276037, -0.04049643874168396, -0.04309673607349396, -0.01696087419986725, 0.03161384537816048, 0.02310103364288807, 0.003469716524705291, -0.016382044181227684, -0.0038522323593497276, 0.006655883975327015, 0.006095873191952705, -0.051741376519203186, 0.017522035166621208, -0.018399927765130997, -0.0033499428536742926, -0.013816923834383488, -0.007202792912721634, 0.005515245255082846, 0.013341650366783142, -0.0023456846829503775, 0.017714116722345352, -0.00337880477309227, -0.052996717393398285, -0.00312710739672184, 0.017971238121390343, -0.011460169218480587, -0.009482422843575478, 0.025604672729969025, -0.0015588556416332722, -0.07414375990629196, -0.02387342043220997, -0.006609492003917694, -0.004926812835037708, 0.010231859982013702, 0.023712238296866417, -0.015782736241817474, 0.005551325157284737, -0.010724756866693497, 0.005396118387579918, -0.010766221210360527, -0.02269257791340351, 0.00030279322527348995, -0.0019456883892416954, 0.012803683988749981, 0.012262873351573944, 0.004276149906218052, -0.01554403081536293, 0.0012928408104926348, -0.007364923134446144, 0.026297958567738533, 0.005081895738840103, 0.0037060328759253025, 0.0024079331196844578, -0.0019782143644988537, -0.0802079439163208, 0.03529730439186096, -0.0209788978099823, -0.043864116072654724, 0.0013956911861896515, -0.019178982824087143, 0.024240903556346893, -0.014249693602323532, -0.019228003919124603, -0.01760706678032875, 0.021509956568479538, 0.013681245036423206, -0.004488050006330013, -0.007548259571194649, 0.009160920046269894, -0.013177480548620224, 0.02309849113225937, -0.002373029477894306, -0.015169529244303703, 0.0216511357575655, 0.015776583924889565, 0.007954210974276066, -0.006859774701297283, 0.02260364033281803, -0.014776148833334446, -0.021423036232590675, -0.008206142112612724, 0.012792635709047318, 0.010091613046824932, -0.006826323457062244, -0.01123768836259842, -0.019414890557527542, -0.029209405183792114, 0.005246458575129509, 0.002587682567536831, -0.0155229102820158, -0.0012105116620659828, -0.0036992086097598076, -0.038064759224653244, -0.0029540928080677986, -0.01041322760283947, 0.017854271456599236, -0.010868245735764503, 0.016214624047279358, 0.01725151762366295, 0.0037547973915934563, 0.006800359580665827, -0.0026251531671732664, -0.0006333247292786837, 0.013365405611693859, 0.001107450807467103, -0.021334748715162277, 0.011339778080582619, -0.009503130801022053, 0.022442568093538284, 0.036479633301496506, -0.004761100746691227, 0.009944241493940353, -0.0036070439964532852, 0.016760753467679024, -0.00979180820286274, 0.021957818418741226, -0.00548666063696146, 0.07177875190973282, -0.01787494868040085, 0.00628115888684988, 0.009476140141487122, -0.014497159980237484, 0.0060191405937075615, 0.00029869331046938896, -0.002604615641757846, 0.0011721090413630009, -0.000664516119286418, -0.0167868509888649, -0.013780318200588226, 0.0012815709924325347, 0.00962788425385952, -0.02336815930902958, 0.00596795417368412, -0.018669188022613525, -0.02372513897716999, 0.033279165625572205, 0.011026877909898758, -0.005344833713024855, -0.03391871601343155, -0.043401461094617844, 0.005760660395026207, 0.01973329856991768, -0.023305770009756088, -0.013098337687551975, -0.004282636102288961, -0.011484804563224316, -0.000363138853572309, -0.004179896786808968, 0.003006111364811659, 0.007341621443629265, 0.005288802087306976, 0.012417477555572987, -0.010611169040203094, -0.0012327939039096236, 0.006469335872679949, -0.00924600288271904, -0.017045345157384872, 0.02962236851453781, -0.008341913111507893, -0.006785362958908081, -0.008235329762101173, -0.005191783886402845, -0.007101644761860371, 0.005122926086187363, 0.010282326489686966, 0.008848793804645538, 0.00035594648215919733, 0.014538065530359745, 0.0004119009245187044, 0.004195768851786852, 0.007268952205777168, -0.007274736650288105, 0.04141361266374588, -0.00965349841862917, 0.013543213717639446, -0.021079031750559807, -0.007236394099891186, 0.015307053923606873, -0.014987707138061523, -0.022211166098713875, -0.011252082884311676, 0.010000481270253658, 0.01255605835467577, 0.0036217595916241407, -0.01599762588739395, -0.026918623596429825, 0.019308485090732574, 0.028063468635082245, 0.010855632834136486, 0.007215208373963833, 0.0021641766652464867, 0.019260812550783157, 0.016739310696721077, 0.02350941300392151, -0.03157448023557663, 0.002333626616746187, 0.014935435727238655, -0.006749357562512159, 0.02639603614807129, 0.030140012502670288, -0.016816258430480957, -0.022620253264904022, 0.0153620894998312, 0.0004242975264787674, -0.025197308510541916, -0.003890943480655551, 0.015500228852033615, -0.02411505952477455, 0.008559701964259148, -0.001716287457384169, -0.00336465728469193, 0.005990053527057171, 0.034707486629486084, -0.016845351085066795, 0.009868732653558254, -0.007686086930334568, 0.002650183392688632, -0.009504260495305061, -0.01080756913870573, -0.024697808548808098, 0.010354970581829548, -0.031059501692652702, -0.013644548133015633, -0.0030848775058984756, -0.0035989258904010057, -0.0005294210277497768, 0.018754515796899796, -0.006936503108590841, -0.003450218588113785, 0.04952796548604965, 0.014594878070056438, -0.004882281646132469, 0.025516044348478317, -0.0025247004814445972, 0.06721963733434677, 0.012532729655504227, -0.014965957030653954, -0.032935697585344315, -0.020128272473812103, 0.00807844940572977, 0.02116946130990982, -0.011768154799938202, -0.008319126442074776, -0.0058096847496926785, 0.0187334306538105, 0.016214651986956596, -0.011710692197084427, 0.032093148678541183, -0.03732368350028992, -0.004052178002893925, 0.007847360335290432, -0.0030249489936977625, -0.029230281710624695, -0.013051786459982395, -0.013219054788351059, -0.03015514835715294, 0.016437876969575882, 0.011440742760896683, -0.0072990115731954575, -0.005969545803964138, -0.015573840588331223, 0.010322902351617813, -0.006030632648617029, -0.009796377271413803, -0.01783173345029354, -0.0019746930338442326, 0.008100500330328941, 0.008570028468966484, 0.0332501195371151, -0.004108949098736048, -0.007410608232021332, -0.02835935913026333, 0.009451333433389664, 0.005033593159168959, 0.016261929646134377, -0.012136785313487053, -0.00449460931122303, -0.021222928538918495, 0.01698923483490944, 0.017649587243795395, 0.021697301417589188, -0.018705258145928383, 0.01682259514927864, -0.0021596045698970556, 0.005284806713461876, 0.015026824548840523, -0.018396100029349327, 0.03308793157339096, -0.0342981293797493, 0.018005218356847763, -0.0006450334331020713, -0.03980761021375656, 0.005372507497668266, -0.007030186243355274, -0.01315358467400074, -0.005069150123745203, 0.004232280422002077, -0.02452155202627182, -0.016317039728164673, 0.006563653703778982, -0.010342076420783997, -0.0003010046202689409, 0.03121042251586914, -0.011197985149919987, 0.0002908380702137947, 0.01940564252436161, 0.006942790001630783, 0.003166106529533863, -0.008575955405831337, -0.0005312417633831501, 0.010070392861962318, -0.001166285015642643, -0.02336389385163784, 0.0021107264328747988, -0.0025527477264404297, -0.012425117194652557, -0.0073963673785328865, -0.014459500089287758, -0.0146831339225173 ]
[ 0.21493272483348846, 0.0761016383767128, -0.40225905179977417, -0.1492558717727661, -0.00022153329337015748, -0.1643136888742447, -0.10660267621278763, -0.033714331686496735, -0.06666793674230576, -0.2577247619628906, 0.23291394114494324, 0.2288852483034134, -0.8669954538345337, 0.2917824387550354, -0.3509652018547058, 1.0406502485275269, 0.16730937361717224, 0.4222249686717987, -0.35181763768196106, -0.4782707989215851, 0.030399907380342484, -0.4333082139492035, 0.371033251285553, -0.1946929544210434, 0.1602640151977539, -0.047028325498104095, 0.71187824010849, 0.09960861504077911, 0.3656027913093567, -0.2047630399465561, -0.3406106233596802, 0.45762500166893005, 0.32862311601638794, -0.2275984138250351, -0.5969952344894409, -0.12097377330064774, -0.47901540994644165, -0.14053718745708466, 0.10706883668899536, 0.1777370721101761, -0.2649092972278595, -0.30851879715919495, -0.5834531188011169, 0.7576829195022583, 0.07408790290355682, -0.04562142491340637, -1.5605710744857788, 0.5405548810958862, -0.19473809003829956, -0.152811661362648, 0.2496175318956375, 0.28607672452926636, 0.22788690030574799, 0.17586646974086761, 0.3004358112812042, 0.2812824845314026, -0.9343804717063904, -0.4198582172393799, 0.488623708486557, -0.20215782523155212, 0.11344046890735626, 0.030178425833582878, 0.007246752269566059, 0.24175520241260529, 0.3575524389743805, 1.0802147388458252, -0.24490734934806824, -0.18155023455619812, -0.5692622661590576, -0.0033104794565588236, 0.07006937265396118, -0.24902822077274323, -0.1469261795282364, 0.36858639121055603, -0.24677002429962158, 0.19634698331356049, -0.30533158779144287, -0.7251718044281006, 0.44644856452941895, 0.05330565199255943, 0.23008152842521667, -0.08101873844861984, 0.17808683216571808, 0.20973166823387146, 0.029679449275135994, 0.3515740633010864, 0.046202436089515686, 0.5669519305229187, -0.6755675673484802, 0.11702236533164978, -0.22603443264961243, -0.20436084270477295, 0.3288514018058777, 0.2608564496040344, 0.01673078164458275, 0.47219711542129517, -0.5891289114952087, 0.30557721853256226, -0.18300966918468475, 0.25631481409072876, -0.18542446196079254, 0.20023146271705627, -0.22096361219882965, -0.11489150673151016, -0.8324602842330933, -0.3128352165222168, -0.02272919751703739, -0.36581358313560486, -0.20309114456176758, 0.08389153331518173, -0.8574460744857788, 0.17003189027309418, -0.6337568163871765, -0.029309848323464394, 0.018900126218795776, 0.45645374059677124, 0.27388033270835876, -0.24897803366184235, 0.29243797063827515, 0.14413724839687347, -0.44392701983451843, 1.3575482368469238, -0.3575623333454132, 0.16919372975826263, 0.1866462677717209, -0.23095397651195526, -0.11062625795602798, 0.42598459124565125, -0.17920613288879395, 0.6686879992485046, 0.2581096291542053, 0.928524374961853, -0.34271714091300964, -0.005441051442176104, 0.37030836939811707, 0.07670801132917404, 0.22240471839904785, -0.019603192806243896, 0.23993289470672607, -0.01513367798179388, -0.36445578932762146, -0.3616879880428314, -0.4625588059425354, -0.24997460842132568, -0.20132094621658325, -0.3739708662033081, -0.4000687003135681, 0.4040232300758362, 0.19881942868232727, 0.04509076476097107, 0.3205503523349762, -0.4783790707588196, -0.520733654499054, -0.11928621679544449, -0.485794335603714, 0.33055347204208374, -0.3209408223628998, -0.20801767706871033, -0.20903334021568298, 0.47613781690597534, -0.19324734807014465, 0.18799005448818207, -0.5470984578132629, 0.12010832875967026, 0.641761064529419, 0.008514930494129658, 0.5715369582176208, 0.2214624583721161, 0.09960220009088516, 0.11665265262126923, -0.5720118284225464, -0.633897602558136, -0.1419503092765808, -0.5204820036888123, -0.024535933509469032, 0.03619067370891571, 0.2905145585536957, -0.17590752243995667, 0.07203275710344315, -0.5216884016990662, -0.9134567379951477, -0.25644880533218384, -0.19607578217983246, -0.1824355572462082, 0.5567474961280823, 0.1572435051202774, 0.5066419839859009, 0.2949737012386322, -0.00553213432431221, 0.4274117350578308, 0.13403485715389252, -0.30411213636398315, 1.024195909500122, -0.4510803520679474, 1.5243176221847534, 0.1658536195755005, -0.36674001812934875, 1.3162801265716553, -0.1361258178949356, 0.0041745007038116455, -0.279902845621109, -0.01950829289853573, 0.36644455790519714, -0.3967200219631195, -0.42915719747543335, 0.072992242872715, -0.37875640392303467, 0.011913799680769444, 0.17061792314052582, -0.004560812376439571, 0.4678693115711212, -0.21019309759140015, 0.31397736072540283, 0.19354982674121857, 0.23527301847934723, -0.4874871075153351, 0.4518572986125946, -0.25336790084838867, -0.42300841212272644, -0.40091070532798767, 0.3036511242389679, -0.8071480989456177, 0.5077739357948303, 0.6299818754196167, -0.05192972719669342, 0.7382256388664246, 0.4599418640136719, 0.2230033427476883, 1.0861228704452515, 0.14806678891181946, 0.28012001514434814, -0.14133505523204803, 0.5237888693809509, -0.509885847568512, -0.06495139747858047, 0.3626631796360016, -0.18677334487438202, -0.05422443151473999, 0.27060434222221375, 0.17500023543834686, -0.20955777168273926, 0.7912236452102661, -0.8271293640136719, -0.49766629934310913, 0.27808940410614014, -0.39188718795776367, -0.27731794118881226, 0.6355047225952148, -1.2093547582626343, -0.0851370170712471, -0.052782073616981506, 0.035892996937036514, 0.4351356029510498, -0.40580230951309204, 0.007395298685878515, 0.38255396485328674, -0.3972090780735016, -0.240645170211792, 0.07846580445766449, -0.2433692067861557, -0.2793198823928833, 0.11728676408529282, 0.16757802665233612, 0.2809879183769226, 0.14458073675632477, -0.31588301062583923, -0.8278622031211853, 0.15825846791267395, 0.8897144794464111, 0.39131686091423035, 0.9033113718032837, 0.1869145780801773, -0.818013072013855, -0.011496716178953648, 0.19638390839099884, -0.15153594315052032, -0.49646854400634766, 0.7919511198997498, -0.5670146346092224, -0.045714084059000015, 0.11147776991128922, 0.3265160024166107, 0.8414273858070374, -0.6804667711257935, -0.550222635269165, 0.36467504501342773, -0.20113980770111084, -0.267861932516098, -0.6467151641845703, -0.30049362778663635, -0.10260698944330215, 0.46850162744522095, -0.46296221017837524, -0.23274007439613342, 0.31204962730407715, 0.12730343639850616, -0.11265971511602402, 0.10763761401176453, 0.5258978605270386, 0.03582985699176788, -0.2361753135919571, 0.5514117479324341, -0.5282742977142334, -0.4789838194847107, -0.21620890498161316, 0.26706796884536743, -0.1359955072402954, 0.11204671859741211, -5.697904109954834, 0.3313561677932739, -0.014176610857248306, -0.18338043987751007, -0.18128672242164612, -0.36979547142982483, 0.8562362194061279, -0.1573110669851303, 0.27144864201545715, 0.2770386338233948, 0.2192402184009552, 0.28197798132896423, 0.058271218091249466, -0.1122976765036583, -0.17354169487953186, -0.1562385857105255, -0.2130945771932602, 0.0962948128581047, 0.7761640548706055, -0.048991959542036057, 0.23097346723079681, -0.24078068137168884, -0.1372954100370407, 0.336203932762146, 0.025492075830698013, 0.0906442180275917, -0.9940789937973022, 0.49183258414268494, -0.03294551745057106, -0.4529394507408142, 0.7508476972579956, -0.22717608511447906, -0.08345048874616623, -0.4412676990032196, 0.4157979488372803, 0.04168175533413887, -0.02740943431854248, 0.053072646260261536, -0.48858001828193665, 0.04448568448424339, 0.09538139402866364, -0.4560035765171051, -0.12796355783939362, -0.4069194197654724, 0.0028802338056266308, -0.1022108867764473, 0.003829320427030325, 0.09186739474534988, -0.17712193727493286, 0.4287765622138977, -0.20871199667453766, -0.5140489339828491, 0.6010322570800781, 0.7893663048744202, 0.68155437707901, 0.1886277049779892, -0.06773637235164642, -0.20634590089321136, -0.6724117398262024, 0.07287677377462387, -0.20138941705226898, 0.004417718853801489, -0.4976583421230316, -1.0921751260757446, 0.1635252684354782, -0.009422661736607552, -0.2644921839237213, -0.17271536588668823, 0.5529394745826721, -0.2857316732406616, -0.15617337822914124, 0.20474720001220703, -0.04774904623627663, -0.7980613708496094, 0.5632238388061523, -0.21765822172164917, -0.0944269523024559, 0.3236689865589142, -0.291277676820755, -0.04444374144077301, -0.3040805160999298, -0.2619433104991913, -0.44997623562812805, 0.036150023341178894, 0.37706658244132996, -0.3000209927558899, -0.2374558299779892, 0.5081222057342529, -0.15304428339004517, 0.3347296118736267, 0.12876814603805542, -0.005081929266452789, 0.0049930717796087265, 0.29249289631843567, -0.16096852719783783, -0.04883567616343498, -0.09221391379833221, 0.48489758372306824, 0.9221059679985046, 0.05844332277774811, 0.7444475889205933, -0.26225167512893677, -0.2697400450706482, -0.7387000322341919, -0.019579540938138962, -0.014389845542609692, -0.5906104445457458, -0.11240394413471222, 0.6170076131820679, -0.9450196623802185, 0.04808700084686279, 0.0035095978528261185, -0.33231234550476074, -0.1576468050479889, 0.8817624449729919, -0.5388922691345215, -0.06169620528817177, 0.0911157876253128, 0.7554923892021179, -0.41334453225135803, 0.4087396264076233, 0.5056091547012329, -0.6800699830055237, 0.09871391206979752, -0.017884453758597374, 0.07809069007635117, 0.17668516933918, 0.9000887274742126, -0.9577354788780212, 0.05898824706673622, 0.3237351179122925, 0.4122336208820343, -0.6493837833404541, -0.13068518042564392, 0.4787563681602478, -0.3723073899745941, -0.5124868154525757, 0.3276333510875702, 0.060347385704517365, 0.001259706332348287, 0.2515709400177002, -0.629237174987793, 0.4417160451412201, 0.4055699110031128, 0.26909610629081726, 0.16830626130104065, 0.2569011151790619, 0.10593535006046295, -0.4510246217250824, -0.4835692346096039, 0.6059329509735107, -0.13521279394626617, 0.2947634160518646, 0.06314998865127563, -0.08604168891906738, 0.7490312457084656, 0.716210126876831, 0.3036309778690338, -0.010070684365928173, -1.042174220085144, 0.47451478242874146, 0.224079430103302, -0.39910557866096497, -0.15732188522815704, -0.008675191551446915, -0.7828592658042908, -0.08325009793043137, -0.30311426520347595, 0.1894344836473465, 0.4191787540912628, -0.22343230247497559, -0.4926283061504364, 0.07690338790416718, -0.2470070868730545, -0.02661348506808281, 0.03529847040772438, -0.35789039731025696, 0.010890801437199116, 0.06317221373319626, 0.2707445025444031, 0.19219708442687988, -0.6067742705345154, 0.08297102898359299, 0.2076268047094345, 0.6306384205818176, 0.5600648522377014, -0.13245058059692383, -0.12441713362932205, -0.7052245140075684, -0.6816311478614807, 0.22741521894931793, -0.03695230931043625, 0.6853602528572083, -0.04929012805223465, 0.17599676549434662, -0.13294608891010284, 0.20068871974945068, 0.3863004446029663, 0.1918845772743225, -0.7219077348709106, 0.18217609822750092, 0.399738073348999, -0.018713099882006645, 0.2826663553714752, 0.4422110915184021, -0.23663142323493958, -0.21068423986434937, 0.13569870591163635, -0.5542030930519104, 0.22984649240970612, -0.21161817014217377, -1.1321548223495483, 0.3024633228778839, 0.1625441312789917, -0.0011130679631605744, -0.0036026022862643003, 0.2148267775774002, -0.202220156788826, 0.14685052633285522, 0.11209846287965775, 0.2578863799571991, 0.17911352217197418, 0.15558944642543793, -0.12749409675598145, -0.49633026123046875, -0.03414959833025932, 0.45631280541419983, -0.5259002447128296, 0.35646921396255493, -0.029501836746931076, 0.42405909299850464, -0.44735726714134216, 0.038740821182727814, -0.2855698764324188, -0.22736360132694244, -0.7150542140007019, -0.03399708494544029, 0.409737229347229, 0.26891380548477173, 0.3620491325855255, 0.222623810172081, 0.14690978825092316, -0.2752765715122223, 0.4166695177555084, 0.07876607030630112, 0.11740925163030624, 0.24026143550872803, -0.4782119393348694, -0.2287289947271347, 0.643593966960907, -0.17163513600826263, -0.19169603288173676, -0.115920290350914, 0.3622145652770996, 1.1755788326263428, -0.09673436731100082, -0.10654265433549881, -0.32996895909309387, -0.42142051458358765, 0.3305387496948242, -0.4293147027492523, 0.44122931361198425, -0.1785346269607544, -0.10319104790687561, 0.02809026464819908, 0.11106210947036743, 0.06449535489082336, -0.4729992747306824, 0.3345716595649719, 0.1695118546485901, -0.3438012897968292, -0.30791017413139343, 0.5870118737220764, 0.509062647819519, -0.425790935754776, 0.27658551931381226, -0.24615126848220825, -0.24535617232322693, -0.2364548295736313, 0.6205460429191589, -0.0763455480337143, -0.4373817443847656, 0.8029497265815735, -0.5710502862930298, -0.054039422422647476, -0.6326133608818054, 0.013033845461905003, -0.20743893086910248, 0.05234992876648903, -0.19719892740249634, -0.33603835105895996, -0.10573913902044296, -0.8186757564544678, -0.758159875869751, -0.0322466678917408, 0.05857805535197258, -0.15294727683067322, 0.3316930830478668, -0.0928628146648407, 0.021375205367803574, -0.7284709811210632, 0.7106565237045288, 0.542812168598175, -0.4759224057197571, -0.17297987639904022, 0.22232381999492645, 0.34722450375556946, 0.5753284096717834, -0.22833675146102905, 0.10382302105426788, -0.46243131160736084, -0.21078526973724365, 0.4923906922340393, 0.021060580387711525, -0.4840366244316101, -0.07467198371887207, -0.17966797947883606, -0.09899762272834778, 0.09669780731201172, 0.07246292382478714, 0.33243903517723083, 0.44783687591552734, 0.47369107604026794, -0.11389703303575516, -0.38773128390312195, 0.3341597616672516, 0.12152501195669174, 0.18115714192390442, -0.0962689071893692, 0.8741439580917358, 0.3812575042247772, 0.04190856218338013, -0.05203421786427498, 0.6064255833625793, 0.5325552821159363, 0.46614184975624084, 0.21502350270748138, -0.060877636075019836, -0.2023184597492218, 0.21592503786087036, 0.4701811373233795, 0.1598995476961136, -0.04985489323735237, -0.18430690467357635, 0.6716135144233704, -0.018298834562301636, -0.011885146610438824, -0.07973624765872955, 0.303615003824234, 0.09623248875141144, 0.11963020265102386, -0.536553144454956, -0.5916475653648376, -0.01131387148052454, -0.7080007791519165, 0.1780647188425064, 0.5326904654502869, -0.6021323800086975, -0.6650557518005371, 0.2538982927799225, -0.46644341945648193, -0.00930018536746502, 0.09548094123601913, 0.8685558438301086, -0.12545806169509888, -0.007951062172651291, 0.6460646390914917, 0.4057907462120056, 0.4729160964488983, 0.171833336353302, 0.1489475965499878, -0.2462759017944336, -0.07680396735668182, 0.1489717662334442, 0.298650860786438, -0.20216785371303558, 0.20410214364528656, -0.20284973084926605, -0.4193580150604248, 0.42500653862953186, -0.45147261023521423, 0.3682689070701599, -0.5793732404708862, -0.954602062702179, -0.32820284366607666, -0.30710169672966003, -0.20827838778495789, -0.20655497908592224, 0.06043362244963646, 0.2854471802711487, 0.09559187293052673, -0.9400516748428345, 0.12177565693855286, 0.07846832275390625, 0.021031208336353302, -0.16214026510715485, -0.08265067636966705, -0.22037912905216217, 0.10868372023105621, 0.2907070815563202, -0.23231251537799835, 0.38729649782180786, -0.41544651985168457, 0.5255680680274963, -0.7836136817932129, 0.588861346244812, -0.21973825991153717, 0.2548339366912842, -0.5727577209472656, -0.46827948093414307, 1.1302145719528198, 1.1685298681259155, -0.20920291543006897, 0.14057765901088715, 0.3753759264945984, 0.19638659060001373, 0.2230733036994934, -0.6850208044052124, -0.7080361843109131, -0.5532248020172119, 0.14762325584888458, -0.6889564394950867, 0.5166659355163574, -0.11273977160453796, -0.41783708333969116, -0.3430022895336151, 0.5210279822349548, 0.25747668743133545, -0.20618058741092682, 0.2579445242881775, -0.3140774667263031, 0.18734677135944366, -0.37259989976882935, 0.14527134597301483, -0.7153961062431335, -0.12406587600708008, -0.1478264480829239, -0.16909298300743103, -0.2723068296909332, 0.3071182370185852, 0.16210751235485077, -0.3386712074279785, -0.02166052907705307, -0.02302182838320732, 0.14470773935317993, -0.05214911326766014, 0.1532970517873764, -0.589491605758667, -0.6289407014846802, -0.10292893648147583, 0.1549546867609024, -0.13512973487377167, 0.055261287838220596, 0.20871096849441528, 0.24018456041812897, -0.21547864377498627, -0.1227613091468811, -0.3410564959049225, 0.04917651787400246, 0.13322216272354126 ]
MicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress gene expression in a sequence-dependent manner. We performed single-cell measurements using quantitative fluorescence microscopy and flow cytometry to monitor a target gene's protein expression in the presence and absence of regulation by miRNA. We find that although the average level of repression is modest, in agreement with previous population-based measurements, the repression among individual cells varies dramatically. In particular, we show that regulation by miRNAs establishes a threshold level of target mRNA below which protein production is highly repressed. Near this threshold, protein expression responds sensitively to target mRNA input, consistent with a mathematical model of molecular titration. These results show that miRNAs can act both as a switch and as a fine-tuner of gene expression.
[ 0.013277722522616386, 0.00913751870393753, -0.00441031763330102, 0.0149769252166152, 0.0031952913850545883, -0.020808953791856766, 0.011209162883460522, -0.0029135504737496376, -0.014590369537472725, 0.0018850765191018581, 0.006487748119980097, 0.005480545572936535, 0.005710368975996971, -0.0030664391815662384, -0.002803171519190073, -0.026999229565262794, -0.03404081240296364, -0.00952198263257742, 0.00668224785476923, 0.011464297771453857, 0.0010894688311964273, -0.0012620326597243547, 0.009938916191458702, -0.011991927400231361, 0.00606530299410224, 0.014521148055791855, -0.01605382189154625, 0.00559849850833416, -0.022445667535066605, -0.024263393133878708, -0.008715018630027771, -0.01353066973388195, 0.03430190682411194, -0.01212252676486969, -0.0018295558402314782, -0.023501846939325333, -0.0017917635850608349, 0.017874836921691895, 0.03532523661851883, -0.004474112298339605, 0.015865914523601532, -0.007826759479939938, -0.0005678475135937333, -0.02227499708533287, -0.006251941435039043, -0.011830569244921207, -0.0023731347173452377, 0.02462087944149971, 0.00628887303173542, 0.007804166525602341, -0.008786486461758614, 0.003280552104115486, -0.007686343975365162, 0.04354811832308769, -0.00672185467556119, 0.002144615165889263, 0.01840798743069172, 0.01888968236744404, 0.004049498122185469, 0.03355345129966736, -0.009052959270775318, 0.003451449330896139, -0.003400651039555669, -0.030107229948043823, -0.0032629603520035744, -0.06712392717599869, 0.00570892496034503, 0.006593997590243816, 0.005361227318644524, 0.0075689987279474735, 0.014258425682783127, 0.018357407301664352, -0.005685355979949236, 0.006166825070977211, -0.012991949915885925, -0.0177090372890234, -0.009071609005331993, -0.004937751218676567, -0.00685304356738925, -0.00003971392288804054, 0.025637082755565643, 0.00012359768152236938, -0.012054427526891232, 0.0038399947807192802, 0.008505805395543575, 0.014027826488018036, -0.03679775446653366, -0.012756407260894775, -0.002761258278042078, 0.009140471927821636, -0.005291008856147528, -0.001058831810951233, -0.03264893591403961, 0.005570416804403067, -0.021908637136220932, 0.017582088708877563, 0.006673922762274742, -0.009124274365603924, -0.0035192579962313175, 0.0035438158083707094, -0.028524378314614296, 0.0016031441045925021, 0.01721232198178768, 0.021681342273950577, -0.0399291031062603, 0.013447638601064682, 0.03534262254834175, 0.009450891986489296, -0.00022299867123365402, 0.007775784004479647, -0.015391528606414795, -0.013342089019715786, -0.015398364514112473, 0.0071447077207267284, 0.009816007688641548, 0.02773893252015114, -0.0051088957116007805, 0.02170805260539055, 0.011011170223355293, -0.019329000264406204, -0.016996333375573158, 0.006239376030862331, 0.009660657495260239, -0.011890027672052383, 0.010289632715284824, -0.004907749593257904, 0.017883503809571266, 0.0034315199591219425, -0.028267133980989456, 0.006729729473590851, -0.007461837492883205, 0.021863173693418503, -0.006171589717268944, -0.03511691465973854, -0.01668180711567402, -0.010248098522424698, 0.02375979721546173, -0.007397382520139217, -0.007238841615617275, -0.017972689121961594, -0.0036505768075585365, 0.008832750841975212, 0.005712209735065699, 0.008907581679522991, 0.007748867850750685, -0.0032314059790223837, -0.011312205344438553, 0.00954621471464634, 0.020748615264892578, -0.011435738764703274, 0.004210060462355614, -0.009984748438000679, -0.004335166420787573, -0.0029599000699818134, 0.030512796714901924, 0.008446605876088142, -0.025153208523988724, -0.015117581002414227, -0.0016335002146661282, 0.01719774305820465, -0.002017386956140399, 0.006252793595194817, 0.0150902746245265, 0.007654951419681311, -0.00006334064528346062, -0.023420538753271103, 0.005095308646559715, -0.008745679631829262, 0.002439862582832575, 0.001772372517734766, -0.002584964968264103, -0.0033110908698290586, 0.0059980228543281555, 0.007365483790636063, -0.001835716888308525, 0.002213315572589636, 0.00389320426620543, 0.005500819534063339, -0.009839258156716824, 0.06697040796279907, 0.019928473979234695, 0.007261906750500202, 0.02780148945748806, 0.006916750688105822, 0.00009386532474309206, -0.00773279182612896, 0.002218393376097083, -0.0126978550106287, -0.017455965280532837, 0.022199027240276337, -0.0016890352126210928, 0.005246931686997414, -0.0033735549077391624, -0.015606704168021679, -0.019848808646202087, 0.003752949181944132, -0.0036055883392691612, 0.012426347471773624, 0.0034160471986979246, -0.02513934299349785, 0.003620701376348734, 0.01002612803131342, 0.03209291398525238, 0.012296110391616821, -0.02280413918197155, -0.0037762634456157684, 0.018094446510076523, -0.014628048986196518, 0.005563829094171524, 0.025516081601381302, 0.039656419306993484, -0.006451028399169445, -0.006711967289447784, -0.02159029245376587, 0.016185928136110306, -0.007808826398104429, -0.013763222843408585, 0.017288468778133392, -0.015245487913489342, -0.015469221398234367, 0.0006581294583156705, -0.004956904333084822, 0.002924886532127857, -0.002654824871569872, -0.006286527030169964, -0.004032198339700699, 0.020070074126124382, 0.008328701369464397, -0.007494302000850439, 0.015077970921993256, 0.00025943154469132423, -0.015764256939291954, -0.010176066309213638, 0.0258877482265234, 0.007248746231198311, -0.01974542811512947, 0.010082933120429516, 0.00437966687604785, 0.02073363959789276, -0.008431576192378998, -0.011074035428464413, -0.001132673816755414, 0.019424308091402054, -0.006237741559743881, 0.012578383088111877, -0.013451467268168926, -0.009758888743817806, 0.011488618329167366, 0.010521613992750645, -0.011631261557340622, 0.006313473917543888, -0.0152320247143507, 0.031739745289087296, -0.0236311387270689, 0.007402787916362286, 0.008889537304639816, 0.005447109695523977, 0.00019099877681583166, 0.026050273329019547, -0.00815723929554224, 0.005453107412904501, 0.006338261067867279, -0.01237909123301506, 0.009891235269606113, -0.0017927066655829549, 0.024829238653182983, -0.004282980691641569, -0.007376409135758877, -0.011077736504375935, -0.019549468532204628, 0.0033991204109042883, -0.01188983116298914, 0.0022411763202399015, -0.08154886960983276, -0.002613639924675226, 0.01051384024322033, -0.04149308800697327, 0.010466746985912323, -0.001975840423256159, -0.00407067034393549, 0.025717534124851227, -0.004419029224663973, -0.015785105526447296, 0.017507417127490044, 0.005047965794801712, -0.011754448525607586, -0.001330529572442174, 0.009405534714460373, 0.002326231449842453, 0.012169431895017624, 0.011221926659345627, -0.01977631263434887, -0.02184232696890831, -0.010058056563138962, 0.006200706120580435, -0.03869695961475372, 0.016836252063512802, -0.030995745211839676, -0.007540150545537472, 0.012873135507106781, 0.005903701763600111, -0.002034695353358984, -0.002525459509342909, -0.008662734180688858, -0.02152586355805397, 0.007037599105387926, -0.0019775060936808586, 0.01523997075855732, 0.00961422547698021, 0.006268498487770557, -0.007923392578959465, -0.01963629201054573, 0.02768426574766636, -0.011802242137491703, 0.008632953278720379, 0.026898737996816635, -0.004537154920399189, 0.01607961766421795, 0.0194994043558836, 0.01617524027824402, 0.0432816781103611, 0.014883670955896378, -0.03057652898132801, 0.03058425709605217, -0.0052205659449100494, -0.025828547775745392, 0.014409748837351799, -0.0096939317882061, 0.047768644988536835, -0.02247968316078186, -0.014407003298401833, -0.019500665366649628, 0.0013064952800050378, 0.014738586731255054, -0.0002416861243546009, -0.006152474787086248, 0.01317757647484541, 0.0009789096657186747, -0.018847310915589333, 0.013296928256750107, -0.0207920353859663, -0.01135147362947464, 0.020204130560159683, 0.009843438863754272, -0.004349063150584698, -0.010104470886290073, -0.014910995028913021, -0.013045689091086388, -0.009631972759962082, -0.01407378725707531, 0.008093354292213917, 0.000257616862654686, 0.0005490053445100784, 0.004201020114123821, 0.0016874434659257531, -0.0066469754092395306, -0.0027734674513339996, -0.03174079209566116, -0.010730910114943981, -0.0023629339411854744, 0.025230005383491516, 0.0036341955419629812, -0.017648838460445404, 0.024992574006319046, 0.03170012682676315, 0.019202420487999916, 0.011134408414363861, -0.010076016187667847, -0.03053591214120388, -0.020848160609602928, 0.0014644487528130412, 0.0153134660795331, 0.009948914870619774, -0.042077772319316864, 0.013019535690546036, 0.00418025441467762, -0.012089982628822327, 0.013505769893527031, 0.016570759937167168, -0.005091279745101929, -0.03654831647872925, -0.0014947988092899323, 0.005022768396884203, -0.0076284464448690414, -0.0027726502157747746, -0.014339704066514969, 0.01408017985522747, 0.007824143394827843, 0.014002698473632336, -0.005503378808498383, 0.007077675312757492, 0.0716748908162117, 0.0030035264790058136, -0.0040436116978526115, -0.021192427724599838, 0.017196517437696457, -0.019621502608060837, 0.01682213321328163, -0.006544356234371662, -0.009025875478982925, -0.007328549399971962, 0.013507663272321224, 0.013135475106537342, 0.017189083620905876, 0.033014267683029175, 0.008831199258565903, 0.003372087376192212, -0.005956961773335934, -0.005284490063786507, 0.02119784988462925, 0.017009247094392776, -0.03333168104290962, 0.012643657624721527, 0.006378415040671825, -0.013494433835148811, -0.01624513417482376, -0.015711557120084763, 0.004318456631153822, -0.016594255343079567, 0.0010261776624247432, 0.009355878457427025, 0.019062675535678864, -0.02295921929180622, -0.006388192065060139, 0.03129911050200462, -0.005098162218928337, 0.002178724156692624, 0.03094274178147316, 0.0024985915515571833, -0.007597645279020071, -0.004973351024091244, 0.006916466634720564, -0.012453850358724594, 0.03976639360189438, 0.016734948381781578, 0.013356480747461319, -0.029187049716711044, 0.029518526047468185, -0.007534359581768513, 0.005191379692405462, 0.014559170231223106, -0.00650567514821887, 0.007021775469183922, 0.00925753079354763, -0.0005433200858533382, -0.015185916796326637, -0.012261709198355675, 0.013326655142009258, -0.003986340016126633, -0.0006019517313688993, 0.006569295655936003, 0.0016536747571080923, -0.019001398235559464, 0.02059066668152809, 0.0018746692221611738, 0.01739458553493023, -0.014102250337600708, -0.016329094767570496, 0.004308256786316633, 0.006600996479392052, -0.02115708775818348, 0.023599617183208466, 0.00039566028863191605, -0.01328666415065527, 0.00896428246051073, -0.02060604840517044, 0.008716371841728687, 0.010841062292456627, 0.0019473324064165354, 0.033953674137592316, 0.023192258551716805, 0.004221639130264521, 0.01706298440694809, 0.019653402268886566, -0.004559956956654787, 0.0024410290643572807, -0.032331086695194244, -0.03020544908940792, -0.07485070824623108, -0.00984845869243145, -0.011615324765443802, -0.006599241867661476, 0.02695067971944809, 0.013308988884091377, -0.0157366581261158, 0.012108618393540382, 0.010138359852135181, -0.009997251443564892, -0.016547057777643204, -0.009533366188406944, 0.023489370942115784, -0.007912904024124146, 0.009463747031986713, 0.008882764726877213, -0.0001713056117296219, 0.004967293702065945, -0.0021706114057451487, 0.031131677329540253, -0.0099389823153615, 0.008632980287075043, -0.04637594521045685, 0.01148210745304823, -0.01476813293993473, -0.08077225089073181, -0.00860201008617878, 0.012746554799377918, -0.014543011784553528, -0.028594063594937325, 0.03150461986660957, 0.023384395986795425, 0.005431951954960823, -0.004057801328599453, -0.01851993054151535, -0.023038318380713463, 0.015786904841661453, -0.015146411024034023, 0.014759613201022148, 0.009474361315369606, -0.008275079540908337, 0.006833489052951336, 0.033940672874450684, -0.013212312012910843, -0.010220049880445004, 0.016100116074085236, 0.012938088737428188, -0.011677537113428116, -0.002388307824730873, -0.007805751636624336, 0.012914661318063736, -0.0021313349716365337, 0.01568887010216713, -0.0033365932758897543, 0.026728181168437004, -0.007830942049622536, 0.010924475267529488, 0.0029798634350299835, -0.01894817315042019, 0.0003170154523104429, -0.021619955077767372, -0.02410329133272171, -0.012108945287764072, -0.0175970196723938, -0.011972429230809212, -0.012911219149827957, -0.007751070894300938, -0.03720895200967789, 0.0026802541688084602, -0.005788219161331654, -0.015971118584275246, 0.00418995413929224, 0.002282681642100215, 0.006949923932552338, -0.010199520736932755, 0.00778141338378191, 0.011064781807363033, 0.013493703678250313, 0.00024395808577537537, 0.014474392868578434, 0.024194445461034775, -0.00769037427380681, 0.015501780435442924, 0.0048879701644182205, 0.016641195863485336, -0.0023115440271794796, 0.009798936545848846, 0.004083696752786636, 0.0719708502292633, 0.006989133544266224, 0.01920747384428978, -0.018087171018123627, 0.005602892953902483, 0.00554780475795269, -0.013851914554834366, -0.02905980497598648, 0.002898188540711999, -0.016206122934818268, -0.008005472831428051, -0.004868675023317337, -0.0013538443017750978, 0.01413821242749691, -0.027462247759103775, 0.025824930518865585, -0.015846678987145424, -0.00037716771475970745, 0.010555223561823368, 0.016446951776742935, -0.005013362504541874, -0.02737133577466011, -0.04627621918916702, -0.01437813974916935, 0.007090205326676369, -0.01304103247821331, -0.03427155688405037, 0.027244657278060913, -0.025347033515572548, 0.02475433051586151, -0.00434383749961853, -0.011979440227150917, 0.000005691195838153362, 0.012987179681658745, 0.02444881945848465, 0.0008697700686752796, -0.01636766828596592, 0.004438769072294235, 0.00599676463752985, -0.005980284884572029, -0.004226613324135542, -0.012288619764149189, 0.004037260077893734, -0.007281421683728695, 0.0136059345677495, 0.01331920176744461, -0.01297248899936676, -0.0010358759900555015, 0.023726673796772957, 0.009804587811231613, -0.007867539301514626, -0.006334594916552305, 0.0006842475850135088, -0.034723587334156036, 0.0005923674907535315, 0.011395296081900597, -0.008616738021373749, 0.013925405219197273, -0.004609938245266676, 0.021592184901237488, -0.02302967756986618, -0.007993130013346672, -0.009842809289693832, -0.019128847867250443, 0.03179216384887695, -0.01897667720913887, 0.0019781922455877066, -0.010850740596652031, 0.020231079310178757, 0.022463358938694, -0.03861483186483383, 0.01899132691323757, 0.007906002923846245, -0.0015829207841306925, 0.04425862431526184, 0.007827027700841427, 0.04268636554479599, -0.010418429039418697, 0.010864834301173687, 0.02435673587024212, -0.014187938533723354, 0.017787951976060867, 0.0005728455726057291, -0.009374603629112244, -0.046921469271183014, -0.01811419427394867, 0.004835827741771936, -0.00693765701726079, -0.0019978699274361134, 0.005813430063426495, 0.02380477823317051, 0.006461953744292259, 0.007049181964248419, -0.0021985480561852455, 0.004138381220400333, 0.035337600857019424, 0.01859600469470024, 0.004548630211502314, -0.02241479977965355, 0.008539438247680664, 0.008266360498964787, 0.0017471113242208958, -0.009909559972584248, 0.020541982725262642, -0.00780266709625721, -0.0030871748458594084, -0.009049972519278526, 0.017457999289035797, 0.008338733576238155, -0.023495638743042946, 0.04377886652946472, -0.010701472871005535, -0.007365348283201456, -0.002595258178189397, 0.01242817472666502, 0.018161112442612648, 0.005522015504539013, 0.009617405943572521, -0.01542125828564167, -0.015601659193634987, 0.008825737051665783, 0.005774715915322304, 0.002090658061206341, -0.0025449495296925306, 0.039321281015872955, -0.018162434920668602, -0.0073576029390096664, 0.06253385543823242, 0.026304669678211212, 0.01024671085178852, 0.013305803760886192, 0.007068185601383448, -0.020405463874340057, -0.006079485174268484, -0.00270525342784822, 0.031399138271808624, 0.012299779802560806, 0.005147266201674938, -0.008097270503640175, -0.019630342721939087, 0.00878993421792984, -0.021890830248594284, 0.004408853594213724, 0.015052346512675285, 0.008448489010334015, 0.028489239513874054, 0.021788910031318665, 0.014808732084929943, 0.006173338741064072, 0.006409035995602608, -0.004619993735104799, 0.012587928213179111, 0.012826696038246155, -0.008341234177350998, 0.004940397571772337, 0.0118115758523345, -0.002837970620021224, -0.030539147555828094, 0.004018031060695648, 0.01371937058866024, 0.02387779951095581, 0.014813927933573723, 0.03366631641983986, -0.011506523936986923, -0.002985184546560049, -0.02628079056739807, 0.012163032777607441, 0.03350716829299927, -0.024530228227376938, -0.0011545363813638687, 0.01770675554871559, -0.02398408204317093, 0.015077922493219376, 0.033929310739040375, -0.006940370891243219, -0.008679406717419624, -0.020110491663217545, 0.00809417013078928, 0.017701145261526108, -0.0010778449941426516, 0.01027711108326912, -0.028443917632102966, 0.013003326952457428, -0.004025829955935478, -0.0015908288769423962, 0.006974708754569292, -0.005240569822490215, 0.03173237293958664, 0.007391607854515314, -0.003095132764428854, -0.0009143571369349957, 0.01206224225461483, -0.01922426000237465, 0.015594800934195518, -0.01813153736293316, -0.01772793009877205, -0.014246346428990364, -0.0030926126055419445, 0.006715062540024519, 0.008099921979010105, 0.000698198564350605, -0.0038177822716534138 ]
[ 0.21672625839710236, -0.07696736603975296, -0.02284058928489685, 0.05251186341047287, 0.21769337356090546, -0.3188030421733856, 0.41398128867149353, -0.054458629339933395, -0.3528713881969452, -0.355731725692749, 0.10211466252803802, -0.13101854920387268, -1.0402345657348633, 0.6768878102302551, -0.3117086589336395, 0.617685079574585, -0.10492203384637833, 0.353104829788208, 0.10204295814037323, -0.5594501495361328, -0.26126718521118164, -0.2377920299768448, 1.0351080894470215, -0.21556909382343292, 0.5336979031562805, -0.05525318533182144, 0.6055065393447876, -0.11840994656085968, 0.48137691617012024, 0.11470077931880951, -0.2263244241476059, 0.5220238566398621, 0.44979968667030334, 0.2684701085090637, 0.0673045739531517, -0.01440958958119154, -0.7060093283653259, 0.4616938531398773, 0.15389090776443481, -0.1239018440246582, -0.17236779630184174, -0.44543570280075073, -0.6295206546783447, 0.49653732776641846, -0.08795557171106339, -0.4877462089061737, -1.0580347776412964, 0.9927660822868347, -0.20410963892936707, 0.07445226609706879, -0.36359044909477234, 0.3302287459373474, 0.8558465242385864, 0.08118322491645813, 0.3357067406177521, 0.07102872431278229, -0.24375751614570618, -0.06587722152471542, 0.4577096402645111, -0.7209611535072327, 0.20429638028144836, 0.12494784593582153, -0.1513700783252716, 0.26313596963882446, -0.16644500195980072, 0.5908098816871643, 0.14566735923290253, -0.6952718496322632, -0.33359500765800476, -0.6792604327201843, -0.031832970678806305, -0.2976323068141937, -0.09479193389415741, 0.3505035638809204, -0.07049863040447235, -0.20363709330558777, -0.19177080690860748, -0.06035160645842552, -0.0728941485285759, -0.06102963536977768, -0.4190693497657776, 0.33332788944244385, 0.19188717007637024, 0.236774742603302, 0.2460721731185913, -0.4051910936832428, -0.7279758453369141, 0.645673394203186, -0.3264429569244385, 0.15619289875030518, 0.008303260430693626, 0.04257332906126976, 0.4730285108089447, 0.48105984926223755, 0.1559707075357437, 0.04780913516879082, -0.09327822178602219, -0.1750250905752182, -0.04260861501097679, 0.6086936593055725, -0.11698344349861145, 0.14828504621982574, 0.10238456726074219, -0.8472209572792053, -0.3763883113861084, -0.4321191608905792, 0.044121041893959045, -0.7605623602867126, -0.1773522049188614, 0.30236753821372986, -0.7854542136192322, 0.16744600236415863, -0.3915942907333374, -0.1714569330215454, -0.0789262130856514, -0.0497329980134964, 0.31815841794013977, -0.7864693999290466, 0.09012797474861145, 0.1821465939283371, 0.08296559751033783, 1.3799880743026733, 0.14822924137115479, 0.20352210104465485, 0.04065593332052231, -0.20834441483020782, 0.14598126709461212, -0.5862157344818115, -0.738629937171936, 0.50982266664505, 0.44055524468421936, 1.6477391719818115, -0.6824353337287903, 0.0920449048280716, -0.14879004657268524, 0.21252571046352386, 0.1206904873251915, 0.10917606204748154, 0.7259088158607483, -0.2814149260520935, -0.570166289806366, -0.418660432100296, -0.31660014390945435, 0.12909190356731415, -0.030979936942458153, -0.5526527166366577, -0.23660078644752502, -0.47926080226898193, -0.25116991996765137, -0.31375622749328613, -0.4156247079372406, -0.3082873523235321, -0.3765428066253662, 0.1467398852109909, -0.1693200170993805, -0.2830468714237213, 0.4312109351158142, -0.03311191499233246, 0.17548400163650513, 0.5023261904716492, -0.11476714164018631, -0.2020922601222992, -0.7619720697402954, -0.32129237055778503, 0.43311411142349243, -0.1376754641532898, 0.3522631824016571, 0.6468407511711121, -0.07390564680099487, -0.08303818851709366, -0.03703306242823601, -0.04327525198459625, 0.5885099172592163, -0.9888767004013062, -0.4065242111682892, -0.5487889051437378, 0.07395849376916885, -0.3972311317920685, 0.08100050687789917, -0.2047938108444214, -0.9102685451507568, -0.49153047800064087, 0.07163480669260025, -0.035076677799224854, 0.3546528220176697, 0.1530410796403885, 0.4890843629837036, 0.3086964786052704, 0.018828148022294044, -0.3050113916397095, -0.4594558775424957, -0.13180509209632874, 0.25286921858787537, -0.5933877825737, 1.2627097368240356, 0.020117921754717827, 0.2072240114212036, 2.0938408374786377, 0.042739976197481155, -0.041448794305324554, -0.34561827778816223, -0.06602167338132858, 0.6851686835289001, -0.8567474484443665, -0.6209596991539001, 0.0038157787639647722, -0.09135890752077103, 0.027923455461859703, 0.07125823199748993, -0.029093356803059578, 0.14752766489982605, -0.4719485938549042, -0.31423449516296387, -0.585940420627594, 0.3223252296447754, -0.4846000671386719, -0.13062292337417603, 0.06790625303983688, -0.5840355753898621, 0.19005514681339264, 0.8573930263519287, -0.8862462639808655, 0.5606095790863037, 0.7779624462127686, -0.17509396374225616, 0.8926332592964172, 0.5079555511474609, 0.19802993535995483, 0.8200528621673584, -0.10236229002475739, 0.6661637425422668, -1.3871756792068481, 0.24105465412139893, -0.07550959289073944, -0.060760121792554855, 0.23790232837200165, 0.12111165374517441, 0.36207541823387146, -0.16991256177425385, -0.8529524207115173, -0.0411631241440773, 0.6279838681221008, -0.8292469382286072, -0.16028094291687012, 0.056245334446430206, -0.6748443245887756, -0.370105117559433, -0.05564538761973381, -0.8893240094184875, 0.21460966765880585, 0.1596572995185852, 0.02156573347747326, 0.49614980816841125, -0.6523292660713196, 0.10540062934160233, 0.4258763790130615, -0.1362612545490265, -0.1845746785402298, 0.3174891173839569, -0.5807450413703918, -0.2967652976512909, -0.11282774060964584, -0.05245888978242874, -0.16312505304813385, -0.5010356307029724, -0.7234684228897095, 0.12161768972873688, -0.3157724440097809, 1.0585283041000366, 1.0018353462219238, 0.6022845506668091, 0.08497251570224762, -0.8377084136009216, -0.17488020658493042, 0.12634344398975372, -0.7249356508255005, 0.7242313027381897, 0.8722455501556396, -0.13624930381774902, -0.3480272591114044, -0.17854487895965576, 0.06826293468475342, 0.935375988483429, -0.5352209210395813, -0.5052598118782043, 0.18085657060146332, -0.049319684505462646, 0.11926645040512085, -0.5908145308494568, 0.054254792630672455, -0.6029717326164246, 0.22795018553733826, -0.9567564129829407, 0.029753632843494415, 0.03848306089639664, 0.23529353737831116, -0.21202439069747925, 0.44554603099823, 0.6733802556991577, -0.23817433416843414, -0.534354567527771, 0.334926575422287, -0.34503570199012756, -0.35011500120162964, -0.2621689736843109, 0.5925076603889465, 0.11457300186157227, 0.56788170337677, -5.167568683624268, 0.2264440655708313, 0.00197934010066092, -0.3102380037307739, -0.0980566069483757, -0.3616397976875305, 0.9819067716598511, 0.08683957904577255, 0.1823205053806305, -0.003755240235477686, 0.3436495363712311, 0.02125144936144352, -0.11400245875120163, 0.022033508867025375, -0.07751437276601791, -0.013724629767239094, 0.20757858455181122, 0.08265551179647446, 0.5926589965820312, -0.08874130994081497, 0.6218878030776978, -0.10997922718524933, -0.03972959518432617, 0.11910926550626755, -0.26760441064834595, -0.3236122727394104, -0.8072220683097839, -0.25556111335754395, -0.449213445186615, -0.6337230205535889, -0.32039791345596313, -0.4636818766593933, -0.01938220113515854, -0.5307705402374268, 0.05584267899394035, -0.08503273129463196, -0.2051660716533661, 0.15135228633880615, 0.14117519557476044, -0.27696409821510315, 0.4949450194835663, 0.47594568133354187, 0.16198623180389404, -0.33537882566452026, 0.43269240856170654, 0.06661252677440643, -0.5508987903594971, 0.20733998715877533, -0.32233667373657227, 0.5292293429374695, -0.05079945549368858, -0.38152483105659485, 0.8061046600341797, 0.5797321200370789, 0.5260400772094727, -0.134723961353302, -0.11444738507270813, -0.07761889696121216, -0.6352362036705017, -0.33236318826675415, -0.16449099779129028, -0.10895033180713654, 0.0324607752263546, -0.7614062428474426, -0.1653348207473755, 0.18092983961105347, -1.0756628513336182, -0.43683382868766785, 0.8333596587181091, 0.10151170194149017, -0.42335349321365356, -0.03844311088323593, 0.01505185104906559, -0.4610123038291931, 0.7293090224266052, 0.0010008072713389993, 0.037722524255514145, 0.05035518854856491, 0.03540666028857231, 0.05703113228082657, -0.5878252983093262, 0.12028319388628006, -0.1941031962633133, -0.26179933547973633, 0.6474610567092896, -1.2064716815948486, -0.22514422237873077, -0.528167188167572, -0.6200093030929565, 0.6806069016456604, 0.3288482427597046, -0.40885210037231445, 0.04218587651848793, 0.3113238215446472, 0.9438974261283875, -0.6848912835121155, 0.32563120126724243, 0.6147011518478394, 0.7785518169403076, 0.40237128734588623, 0.4847373962402344, -0.0010369011433795094, -0.16137655079364777, -1.038567304611206, 0.24801547825336456, 0.5132235288619995, -0.700803279876709, 0.5401396751403809, 0.5839270353317261, -0.5389362573623657, 0.17617347836494446, -0.08854803442955017, -0.2039094865322113, -0.09204749763011932, 0.14574037492275238, -0.590153157711029, 0.09179212152957916, 0.28567978739738464, 0.37759560346603394, -0.2222517430782318, -0.3329564034938812, 0.6196889877319336, -0.603502094745636, 0.5316612720489502, 0.08453730493783951, -0.4435591995716095, 0.4285127818584442, 0.42233017086982727, -0.3848550021648407, -0.32581445574760437, 0.7720808386802673, 0.41975972056388855, -0.2963178753852844, -0.8524648547172546, 0.36173081398010254, -0.11345020681619644, -0.21616633236408234, 0.34190070629119873, 0.41417786478996277, -0.45418673753738403, 0.03717556595802307, -0.33764657378196716, 0.5297058820724487, 0.17330722510814667, 0.38728946447372437, 0.7008177638053894, 0.8202744722366333, 0.36444589495658875, 0.059807512909173965, -0.259364515542984, -0.3519531488418579, 0.11154448986053467, -0.044279564172029495, -0.26176461577415466, -0.14850541949272156, 0.3118787109851837, 0.9214490056037903, -0.16262467205524445, 0.5311485528945923, -0.49846675992012024, -0.27640944719314575, 0.16417622566223145, -0.623192310333252, 0.3841876983642578, -0.7389145493507385, -0.15512123703956604, -0.1434907764196396, 0.053175538778305054, 0.12728933990001678, 0.4208502173423767, -0.6409965753555298, 0.2300414741039276, 0.03997364267706871, -0.18140201270580292, -0.14635597169399261, -0.3756618797779083, -0.03557928279042244, 0.2284448891878128, -0.18077826499938965, 0.620633065700531, 0.08590152859687805, -0.42825791239738464, 0.07057556509971619, 0.31695303320884705, -0.00504855765029788, 0.26984652876853943, -0.07850281149148941, 0.19505204260349274, -0.4386805295944214, -0.6672806143760681, 0.2160077691078186, 0.345292329788208, 0.6875794529914856, -0.6998723745346069, 0.17006716132164001, 0.15060937404632568, 0.28720879554748535, 0.9455565214157104, 0.04034944251179695, -0.5241485238075256, 0.20060592889785767, 0.5896918177604675, -0.8061810731887817, 0.4213866889476776, 0.41801100969314575, 0.32076215744018555, -0.5878716707229614, -0.025730524212121964, 0.13085666298866272, -0.1446579396724701, -1.055246114730835, -0.5734673738479614, 0.26985642313957214, 0.4527105391025543, -0.14756837487220764, 0.015355829149484634, 0.1454797387123108, 0.014141116291284561, -0.054619334638118744, 0.006126482971012592, 0.3370712399482727, 0.086567722260952, 0.27451369166374207, -0.36671286821365356, -0.589191198348999, 0.3654169738292694, 0.3116424083709717, -0.8194228410720825, 0.05262468010187149, 0.0186169371008873, 0.10116969794034958, -0.3089836537837982, 0.15498432517051697, -0.2828145921230316, -0.2282543182373047, -0.9051401019096375, -0.09630344063043594, -0.01574704982340336, 0.2432861030101776, 1.0273514986038208, 0.010718472301959991, 0.5924551486968994, -0.25629907846450806, -0.18613198399543762, -0.2668983042240143, 0.38693365454673767, 0.2690926790237427, -0.3502401113510132, -0.47450533509254456, 0.2923976182937622, 0.2509278953075409, -0.24431836605072021, -0.2853148281574249, 0.5750161409378052, 1.4972642660140991, 0.7280144095420837, -0.36223912239074707, -0.05778142437338829, -0.0028874182607978582, 0.11292693018913269, 0.024923663586378098, -0.03950423374772072, -0.37070900201797485, -0.051996856927871704, 0.42470449209213257, 0.1903565227985382, -0.26318302750587463, -0.6279090046882629, 0.6668242812156677, -0.006846509408205748, 0.09656571596860886, 0.3079773187637329, 0.5095601081848145, 0.620244562625885, -0.16228659451007843, 0.6812068223953247, -0.29098397493362427, 0.24983708560466766, -0.271929532289505, -0.2947212755680084, -0.5912739634513855, -0.19614163041114807, 0.40120941400527954, -0.5853632688522339, 0.5362656712532043, -0.9427872896194458, 0.17193135619163513, -0.12484018504619598, 0.09626806527376175, -0.5769788026809692, -0.33430999517440796, -0.18596364557743073, -0.6422936320304871, 0.04691218584775925, -0.03349506855010986, 0.06443174183368683, 0.028418850153684616, 0.03771967440843582, -0.20433549582958221, 0.18280178308486938, -1.1107853651046753, -0.07029078900814056, 0.5304393172264099, -0.5996720194816589, -0.01320197619497776, -0.07808056473731995, 0.1550082117319107, 0.29696860909461975, -0.666124165058136, -0.11462316662073135, -0.43549495935440063, 0.0888362005352974, 0.7862417101860046, -0.0005921555566601455, -0.9308932423591614, -0.18036024272441864, -0.614160418510437, -0.2372654676437378, 0.5465317964553833, -0.25428372621536255, 0.4980562925338745, 0.49854233860969543, 0.24869124591350555, 0.2742738425731659, -0.5102211833000183, 0.4500305950641632, 0.31954851746559143, -0.0966818779706955, -0.4288221299648285, 0.7996212244033813, 0.4973532557487488, -0.07716140896081924, -0.49171754717826843, 0.6687781810760498, 0.07864199578762054, -0.1338297724723816, -0.10687362402677536, -0.36125195026397705, -0.3693821430206299, 0.1504029780626297, 0.8856606483459473, 0.5509474873542786, -0.41232481598854065, 0.2516568899154663, 0.5924132466316223, 0.17119380831718445, 0.6342519521713257, 0.5084706544876099, 0.03369414433836937, 0.24436205625534058, 0.2574160099029541, -0.37125980854034424, -0.16905923187732697, 0.1887720674276352, -0.3345831632614136, 0.39059820771217346, 0.971168577671051, -0.6079396605491638, -0.3604840338230133, -0.05059119686484337, -0.40607860684394836, 0.01490582525730133, -0.2840420603752136, 0.7387369275093079, 0.1346643567085266, 0.07144484668970108, 0.4211474657058716, -0.3353721499443054, 0.4726342260837555, -0.6584003567695618, 0.43059241771698, 0.22497349977493286, -0.2515731453895569, 0.522903561592102, -0.19853153824806213, -0.41318443417549133, 0.1452697217464447, 0.0531720407307148, -0.2934665083885193, -0.11983703076839447, -0.03207409009337425, 0.32506057620048523, 0.2968704104423523, -1.0865058898925781, -0.49385812878608704, -0.16415661573410034, -0.1321430653333664, -0.32977113127708435, 0.5697134733200073, -0.00224309298209846, 0.7159696817398071, -0.8905414938926697, -0.0488949753344059, -0.024182530120015144, -0.10567282885313034, 0.1698402613401413, -0.3047918975353241, 0.520456850528717, 0.6090102195739746, 0.5735533833503723, 0.18443536758422852, 0.17429108917713165, 0.05984603613615036, 0.8534717559814453, -0.7310201525688171, 0.5229264497756958, -0.07805118709802628, -1.0209451913833618, -0.6797744035720825, 0.13039402663707733, 1.434352159500122, 0.5983110666275024, 0.06178290769457817, 0.4200870096683502, 0.6179775595664978, 0.26819977164268494, 0.20935577154159546, -0.9271154999732971, -0.009168539196252823, -0.6509173512458801, 0.48779261112213135, -0.6193650364875793, 0.5469415187835693, 0.3317718803882599, -0.45284122228622437, -0.09861233830451965, 0.5622673034667969, 0.2548108398914337, -0.1958196759223938, 0.047701139003038406, -0.6349218487739563, 0.12998846173286438, -0.27906090021133423, 0.4724717438220978, -0.4298246502876282, 0.36562177538871765, -0.6140097379684448, 0.36824503540992737, 0.29872509837150574, 0.11448971182107925, -0.22387997806072235, -0.05195649713277817, 0.006483715958893299, -0.08538594841957092, 0.10526693612337112, 0.4564514458179474, 0.20582348108291626, -0.767399787902832, -0.7464239001274109, -0.046727973967790604, 0.1429268717765808, -0.6225510239601135, -0.6116479635238647, 0.6001115441322327, -0.010669318959116936, -0.22772501409053802, 0.1964404582977295, -0.4210219085216522, -0.26438796520233154, 0.21682728826999664 ]
Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression. MDSC regulation is widely variable even among patients harbouring the same type of malignancy, and the mechanisms governing such heterogeneity are largely unknown. Here, integrating human tumour genomics and syngeneic mammary tumour models, we demonstrate that mTOR signalling in cancer cells dictates a mammary tumour's ability to stimulate MDSC accumulation through regulating G-CSF. Inhibiting this pathway or its activators (for example, FGFR) impairs tumour progression, which is partially rescued by restoring MDSCs or G-CSF. Tumour-initiating cells (TICs) exhibit elevated G-CSF. MDSCs reciprocally increase TIC frequency through activating Notch in tumour cells, forming a feedforward loop. Analyses of primary breast cancers and patient-derived xenografts corroborate these mechanisms in patients. These findings establish a non-canonical oncogenic role of mTOR signalling in recruiting pro-tumorigenic MDSCs and show how defined cancer subsets may evolve to promote and depend on a distinct immune microenvironment.
[ -0.008780286647379398, 0.005831362679600716, -0.005377343390136957, 0.019411461427807808, 0.015446603298187256, -0.005672199185937643, 0.011910196393728256, -0.012695088051259518, -0.013859130442142487, -0.014342453330755234, -0.012969527393579483, 0.008513987064361572, 0.0015905839391052723, 0.02154337614774704, -0.035463444888591766, 0.0005279863253235817, -0.03411988541483879, -0.0073193577118217945, 0.008270991034805775, -0.009980334900319576, 0.019921481609344482, -0.00820382870733738, 0.01096176914870739, -0.007278687320649624, 0.03084961324930191, 0.02995048463344574, -0.009195446036756039, 0.005936373025178909, -0.029887836426496506, 0.012147759087383747, -0.025881394743919373, -0.0118325874209404, 0.018706215545535088, -0.007295926101505756, 0.007721886970102787, -0.001440741354599595, -0.00014707830268889666, 0.020745452493429184, 0.051816850900650024, -0.005917839705944061, 0.011420327238738537, -0.013979682698845863, 0.003620509058237076, -0.004065391607582569, -0.009445631876587868, -0.004253482446074486, 0.0020327060483396053, -0.00989286508411169, -0.009168162010610104, 0.007654003798961639, -0.00741670373827219, -0.028247827664017677, -0.008958738297224045, -0.0003348980098962784, -0.00657386239618063, 0.0029180620331317186, 0.018378542736172676, 0.005321305710822344, 0.0033847521990537643, -0.0042046732269227505, 0.01969842240214348, -0.028020983561873436, 0.023776402696967125, -0.007998041808605194, -0.005761033855378628, -0.06659431755542755, 0.027653472498059273, 0.009915396571159363, -0.007475418038666248, 0.008247872814536095, 0.009077215567231178, 0.008727263659238815, -0.018354251980781555, -0.035469017922878265, 0.007077107671648264, 0.02109106071293354, -0.012664789333939552, -0.020297015085816383, -0.02165856957435608, 0.011775588616728783, -0.005829630419611931, -0.009798121638596058, -0.02449338138103485, 0.006657962687313557, 0.009621912613511086, -0.007251649163663387, -0.03197824954986572, 0.0012616743333637714, -0.0024379445239901543, 0.017944935709238052, 0.014579753391444683, 0.007817588746547699, -0.022674772888422012, -0.007430216297507286, -0.02678856998682022, -0.0014503970742225647, -0.005249017849564552, -0.013051412999629974, 0.002884246874600649, 0.002814051229506731, -0.017715588212013245, -0.008899878710508347, 0.013436170294880867, 0.005782037507742643, -0.022469401359558105, 0.006180251948535442, -0.0040231626480817795, -0.0158572718501091, 0.020201675593852997, 0.012924516573548317, -0.004476287867873907, -0.007581104524433613, -0.029094669967889786, -0.0030021483544260263, 0.007694173138588667, -0.005697557702660561, -0.017817053943872452, 0.036346275359392166, 0.014936203137040138, -0.004132439382374287, 0.018593821674585342, -0.003424797672778368, -0.0011531844502314925, 0.015119561925530434, 0.007402968127280474, 0.028795897960662842, -0.03474319726228714, 0.017834438011050224, 0.007033120840787888, 0.0031828023493289948, -0.007804702501744032, -0.01189330406486988, 0.008627611212432384, -0.006381544284522533, 0.009563230909407139, -0.0009090611129067838, -0.008470304310321808, -0.010869474150240421, -0.0029361690394580364, -0.03108035773038864, 0.01224089041352272, 0.011928199790418148, 0.003924672957509756, 0.0039192382246255875, 0.011171657592058182, -0.0018412662902846932, -0.004163156729191542, 0.004842772148549557, -0.014106689020991325, 0.010489476844668388, -0.004517962224781513, -0.001139691099524498, -0.015561690554022789, -0.01868325099349022, 0.008043019101023674, 0.024572275578975677, -0.01756865158677101, -0.02063192054629326, -0.002513714600354433, -0.00888685043901205, -0.012548866681754589, -0.04105602949857712, 0.04226623475551605, 0.009707773104310036, -0.006137717515230179, 0.0025219619274139404, 0.0015540444292128086, 0.0035801941994577646, 0.003965756855905056, 0.0028378134593367577, -0.007078357506543398, -0.009150853380560875, -0.0012868288904428482, 0.008532417006790638, -0.014481080695986748, 0.008686024695634842, 0.014015438966453075, 0.00973061565309763, -0.010042889043688774, 0.06636181473731995, 0.011098669841885567, 0.0315537303686142, 0.005137245170772076, -0.016871802508831024, 0.002963779726997018, -0.031125081703066826, 0.005107446573674679, -0.007635675370693207, -0.04549755901098251, 0.009659430012106895, 0.015873689204454422, 0.0005039810203015804, -0.05003964900970459, 0.022939905524253845, -0.04422188922762871, 0.002929698210209608, 0.0033797514624893665, -0.00044501747470349073, 0.0052650077268481255, 0.01913384348154068, 0.030319688841700554, -0.014061056077480316, 0.05216493830084801, -0.023607205599546432, 0.018855594098567963, 0.022422872483730316, 0.01474524475634098, -0.030225323513150215, 0.014278251677751541, 0.012146412394940853, 0.002054261974990368, -0.01047204714268446, 0.001152949407696724, -0.0038684974424540997, 0.021565476432442665, 0.012652330100536346, -0.009723110124468803, 0.017841629683971405, 0.002831317950040102, -0.012823043391108513, -0.007726805284619331, 0.006835935637354851, 0.04819401726126671, -0.0016461131162941456, 0.0004400573670864105, -0.009611567482352257, 0.011526215821504593, 0.012104811146855354, -0.0039011300541460514, 0.006154637783765793, -0.02366902120411396, -0.017331289127469063, -0.01288200356066227, 0.027676470577716827, 0.019861748442053795, 0.006845767144113779, 0.015658996999263763, 0.007903443649411201, 0.019285090267658234, -0.01614709384739399, 0.002413385082036257, 0.0038815485313534737, 0.04262905567884445, -0.024472389370203018, 0.013625397346913815, 0.013613873161375523, 0.03957761824131012, 0.03011501580476761, 0.030831854790449142, 0.009133316576480865, 0.006650358438491821, 0.004316314123570919, 0.017157219350337982, 0.018610738217830658, -0.0120053980499506, -0.004863017238676548, -0.010161781683564186, 0.03624732792377472, 0.02530619129538536, -0.023768097162246704, -0.0027645276859402657, 0.007401464506983757, 0.003953300882130861, 0.0026135118678212166, 0.000714489258825779, 0.019044088199734688, -0.0037534767761826515, -0.003536211559548974, 0.00948248989880085, 0.002280913759022951, 0.00781188765540719, -0.003271966241300106, -0.0011561779538169503, -0.08113797008991241, -0.008517958223819733, 0.018689217045903206, 0.03615352883934975, 0.013093427754938602, -0.029321854934096336, 0.002252790145576, 0.006394248455762863, -0.018062742426991463, -0.0004389490932226181, 0.0038385228253901005, -0.0021666730754077435, -0.005680465139448643, -0.004804128780961037, 0.01963314414024353, -0.003832283429801464, 0.017189305275678635, 0.005688067991286516, -0.006648095790296793, 0.0023457861971110106, 0.04531261324882507, 0.016495104879140854, 0.006648609880357981, -0.0034267581067979336, -0.02400718443095684, 0.012277289293706417, -0.013285797089338303, -0.00753779849037528, -0.020792197436094284, -0.0032219288405030966, -0.010422119870781898, 0.008115965873003006, 0.03072109818458557, 0.02606649324297905, -0.0008859122171998024, 0.019891275092959404, 0.00994892418384552, -0.003159155370667577, -0.02314699999988079, 0.028382468968629837, -0.0027424092404544353, 0.008737841621041298, 0.02725605107843876, -0.00262302253395319, 0.010089351795613766, 0.010946152731776237, 0.023146050050854683, 0.011624322272837162, 0.019224291667342186, -0.0029449393041431904, 0.014823111705482006, -0.0009258099598810077, -0.010031191632151604, 0.010490041226148605, -0.02032596990466118, -0.021379489451646805, -0.03072717785835266, -0.01604161038994789, -0.01577547937631607, -0.01447827648371458, 0.06099008768796921, -0.01664414070546627, 0.012746613472700119, 0.03718821704387665, 0.011388410814106464, -0.0028117517940700054, 0.0008226631907746196, 0.001916305860504508, -0.008876996114850044, -0.011762887239456177, -0.001140170730650425, -0.004274394363164902, 0.0038189971819519997, -0.0022330209612846375, 0.004092777613550425, -0.015138228423893452, -0.012950072064995766, -0.004983403719961643, 0.012834759429097176, -0.030905138701200485, -0.030434943735599518, -0.004381186794489622, -0.027611419558525085, -0.00899876095354557, -0.02538883499801159, -0.011955308727920055, 0.003579880576580763, 0.016749348491430283, 0.00830158218741417, -0.013937175273895264, 0.01823592558503151, -0.005796842277050018, 0.003863132558763027, 0.008552837185561657, 0.02318163961172104, -0.0005606468766927719, -0.01704970747232437, -0.008718275465071201, 0.005001589190214872, 0.00992159266024828, -0.03666163980960846, 0.00877370685338974, 0.0009372225031256676, -0.015955720096826553, -0.009441085159778595, 0.014631304889917374, 0.012025591917335987, -0.024148473516106606, 0.007893507368862629, 0.0046354979276657104, -0.020171694457530975, -0.0011911748442798853, -0.005894564092159271, 0.0480072982609272, 0.01422853209078312, 0.010469892993569374, -0.012437360361218452, -0.019998587667942047, 0.07171428948640823, -0.0060209669172763824, -0.003103419905528426, -0.010986896231770515, 0.03126420080661774, -0.042191099375486374, -0.005955317988991737, 0.02597321942448616, -0.03836594149470329, 0.00012924033217132092, 0.01322639174759388, 0.043080516159534454, 0.005723232869058847, 0.019843438640236855, -0.01110592857003212, 0.02499510534107685, -0.04027071222662926, 0.012550022453069687, 0.0257393941283226, 0.019236955791711807, -0.01960257813334465, -0.007121213711798191, -0.003459107130765915, 0.023909736424684525, -0.01730354316532612, -0.02174326404929161, -0.014503588899970055, -0.013266690075397491, -0.00224821618758142, 0.008056173101067543, 0.010562224313616753, -0.009128181263804436, -0.006088308058679104, -0.004480243660509586, 0.019686155021190643, 0.02051878720521927, 0.023561816662549973, -0.0031653731130063534, -0.004240242298692465, 0.014460435137152672, -0.023136697709560394, -0.018218789249658585, 0.013711374253034592, 0.018875397741794586, -0.017327509820461273, -0.00895280297845602, 0.012427212670445442, -0.00314693502150476, 0.017749732360243797, 0.006709688808768988, -0.012930553406476974, 0.006226484663784504, 0.017272040247917175, 0.004049359820783138, -0.010021739639341831, -0.0014395210891962051, 0.0112234428524971, 0.009407535195350647, -0.008480671793222427, -0.02831304632127285, -0.0181456096470356, 0.01654212921857834, 0.030128175392746925, 0.01625579036772251, 0.015712745487689972, -0.016850430518388748, -0.016689229756593704, 0.008531035855412483, 0.02966385707259178, 0.002741740085184574, 0.007098969537764788, 0.032722748816013336, -0.026386719197034836, 0.009108701720833778, -0.01838010549545288, 0.03164836764335632, -0.014476070180535316, 0.015472106635570526, 0.023483088240027428, 0.028099300339818, -0.006458267569541931, -0.03338033705949783, 0.00821661576628685, 0.005061984062194824, -0.0061821285635232925, -0.016277866438031197, -0.03209180384874344, -0.07470627129077911, 0.01744774542748928, -0.007805204018950462, -0.006669490598142147, 0.017535265535116196, 0.001638628076761961, -0.022759288549423218, 0.005114171653985977, 0.01107177883386612, -0.009295725263655186, 0.0073852622881531715, -0.0013256226666271687, -0.023453664034605026, 0.007682150229811668, 0.013846111483871937, -0.010951025411486626, -0.00807117484509945, -0.012590637430548668, -0.04043281078338623, -0.002620758954435587, 0.01305662002414465, -0.0026903925463557243, 0.00378244835883379, -0.0035342543851584196, -0.0030805026181042194, -0.08046866953372955, 0.01916629448533058, -0.01565907895565033, -0.01785019412636757, -0.006777440197765827, -0.011453380808234215, 0.005840747617185116, -0.01932740956544876, -0.05315803736448288, -0.018970316275954247, 0.00660549383610487, 0.015943054109811783, 0.003420620458200574, -0.008150869980454445, 0.012507757171988487, -0.010385285131633282, 0.011603603139519691, -0.004644117318093777, -0.014181764796376228, 0.008072175085544586, -0.0013855036813765764, 0.01482929103076458, -0.010043739341199398, -0.03125376254320145, -0.0172206349670887, -0.004299934022128582, -0.004069993272423744, 0.015299580991268158, 0.019393645226955414, 0.010464590042829514, -0.019709788262844086, 0.005823182873427868, -0.01717660389840603, -0.013733668252825737, 0.0039038131944835186, -0.02399461902678013, -0.03390040248632431, -0.011399928480386734, -0.022790418937802315, -0.004483979195356369, -0.004272927530109882, 0.021688217297196388, 0.014984694309532642, 0.013528503477573395, 0.017587006092071533, 0.0026064137928187847, 0.0063612195663154125, -0.006613366771489382, 0.01030660793185234, -0.005014442373067141, -0.00017902356921695173, -0.008826599456369877, -0.014493564143776894, 0.014121952466666698, 0.004641659092158079, 0.02414948120713234, -0.005318616516888142, 0.034242935478687286, 0.019313696771860123, 0.013334955088794231, 0.0026369669940322638, -0.006817447952926159, -0.01819387450814247, 0.07137149572372437, 0.0041528623551130295, 0.02973291091620922, -0.005150690674781799, -0.003493846394121647, 0.005554172210395336, -0.05483514815568924, -0.0036724964156746864, -0.015758173540234566, -0.003204012755304575, 0.015632713213562965, -0.009438722394406796, 0.006279733031988144, 0.014836234971880913, -0.0024992525577545166, -0.011681925505399704, 0.006360429804772139, -0.0014773835428059101, -0.008177871815860271, -0.002466361504048109, -0.0005003297701478004, 0.003548462875187397, 0.010976082645356655, 0.016669385135173798, 0.008819030597805977, -0.020001132041215897, -0.0496690571308136, 0.006288239266723394, -0.01684330403804779, -0.007991773076355457, -0.009739590808749199, 0.016522159799933434, -0.0025482219643890858, 0.01397307775914669, 0.02615886926651001, 0.024895038455724716, -0.013309301808476448, 0.0011296105803921819, -0.021343648433685303, -0.002276157960295677, 0.0016121091321110725, 0.011072689667344093, -0.000727425329387188, -0.018420232459902763, 0.013568167574703693, -0.006960928440093994, -0.01831284537911415, -0.034674402326345444, -0.031562551856040955, 0.011582553386688232, 0.03599075973033905, 0.0002573960227891803, -0.013186590746045113, -0.023198280483484268, 0.024142269045114517, 0.014566014520823956, -0.02182754874229431, 0.015444852411746979, -0.008055257610976696, -0.016360200941562653, 0.018040528520941734, -0.013733080588281155, -0.02116510272026062, -0.015268100425601006, 0.02026437409222126, 0.010965678840875626, 0.005399264395236969, -0.011607872322201729, 0.04691440612077713, 0.02158701792359352, -0.01857868954539299, -0.016555678099393845, 0.009799335151910782, 0.003809811780229211, 0.0035045703407377005, 0.006168819963932037, 0.028758946806192398, 0.00010551372542977333, 0.029813118278980255, 0.008710833266377449, -0.014780733734369278, 0.03672953322529793, -0.0050837937742471695, 0.013150570914149284, -0.004428820218890905, 0.036458272486925125, 0.006766492500901222, -0.0020488882437348366, -0.007251588627696037, 0.01507495529949665, 0.01972394436597824, 0.006175011396408081, 0.0006908383220434189, 0.029219012707471848, 0.009066382423043251, 0.03420465067028999, 0.03623179346323013, 0.009672122076153755, 0.007979856804013252, 0.02114906534552574, 0.030545566231012344, 0.005382305942475796, -0.005387237295508385, -0.0051623377948999405, -0.03973441198468208, -0.0049624573439359665, 0.011803206987679005, -0.008283184841275215, 0.020189154893159866, 0.009005105122923851, 0.00839012861251831, 0.0014964432921260595, -0.005549044348299503, 0.0061532300896942616, -0.01309752743691206, 0.012189824134111404, -0.010329535230994225, 0.020978940650820732, -0.012599523179233074, -0.014121206477284431, -0.017919030040502548, -0.002228768076747656, -0.02061208337545395, 0.012615162879228592, -0.014637976884841919, 0.000004018191248178482, -0.013868670910596848, 0.05150195211172104, -0.012720756232738495, 0.004230309743434191, 0.012561741285026073, -0.009817732498049736, -0.007949217222630978, 0.020648159086704254, 0.0049714394845068455, -0.013458185829222202, -0.0022438419982790947, 0.01556782890111208, -0.004803029354661703, -0.00810952391475439, 0.010881153866648674, -0.007786985486745834, 0.0026021674275398254, -0.0030684852972626686, 0.009669240564107895, 0.00389344384893775, 0.0026499186642467976, 0.007404439151287079, 0.0077041275799274445, -0.02311454340815544, 0.02612757310271263, 0.009727146476507187, 0.009829744696617126, -0.004930189810693264, -0.02239871397614479, 0.021824609488248825, 0.01279274933040142, 0.010740570724010468, -0.00929856114089489, 0.00409228028729558, 0.0029656104743480682, 0.008583428338170052, 0.004077717661857605, 0.00047254515811800957, 0.017393188551068306, 0.023096954450011253, -0.016277596354484558, 0.0036454512737691402, -0.013105755671858788, 0.014834745787084103, 0.00914534367620945, -0.006331197917461395, -0.012960723601281643, 0.032048970460891724, -0.02189505472779274, 0.000844521215185523, -0.018958494067192078, -0.024999327957630157, 0.011667112819850445, -0.0024249600246548653, 0.008758099749684334, -0.02571544051170349, 0.0019421165343374014, -0.00868336483836174, -0.023670874536037445, 0.004335722420364618, -0.012097902595996857, -0.006004959344863892, 0.0005531051428988576, -0.024782691150903702, 0.005965368822216988, -0.008923809044063091, 0.00045631546527147293, -0.011941956356167793, -0.005504361353814602, -0.013492677360773087, 0.03458941727876663, -0.011732557788491249, 0.010290692560374737, 0.0020306743681430817, -0.0005137603729963303, -0.01893153041601181 ]
[ 0.44085267186164856, 0.20573954284191132, 0.12381312251091003, -0.027317320927977562, 0.2725965678691864, -0.12421703338623047, 0.015274208970367908, -0.02752074971795082, -0.31851524114608765, -0.41335567831993103, 0.05384950712323189, 0.518947184085846, -0.45069950819015503, 0.25156164169311523, -0.29615330696105957, 0.35797929763793945, 0.5897954106330872, 0.4595920443534851, -0.20699156820774078, -0.7348214983940125, -0.2084101289510727, -0.1568908840417862, 0.5016053915023804, 0.2299584150314331, -0.0490952804684639, -0.3458236753940582, 0.6202604174613953, 0.031502824276685715, 0.6532588005065918, -0.18811796605587006, -0.09571615606546402, 0.7392951846122742, 0.11816130578517914, 0.03310883790254593, -0.22489143908023834, 0.05941127613186836, -0.2548673152923584, -0.12225665897130966, -0.10576840490102768, -0.16370026767253876, -0.11939113587141037, -0.1788967102766037, -0.3587001860141754, 0.2774287462234497, -0.21739743649959564, -0.28894513845443726, -1.4327046871185303, 0.7015825510025024, -0.11273445188999176, -0.2881547212600708, 0.0819329097867012, 0.4197828769683838, 0.060837287455797195, 0.19197066128253937, 0.4883619546890259, 0.2304740846157074, -0.8107129335403442, -0.044322673231363297, 0.33459270000457764, -0.3120359480381012, 0.21908119320869446, -0.08241201192140579, -0.5197343230247498, -0.11653774231672287, -0.07461417466402054, 0.28576216101646423, 0.12826332449913025, -0.21843840181827545, -0.7115048766136169, -0.3117324113845825, -0.06584183126688004, -0.43521833419799805, 0.10292903333902359, 0.33322370052337646, -0.24631965160369873, 0.20775263011455536, -0.18026316165924072, -0.4020872712135315, 0.4543294608592987, -0.1769499033689499, 0.17596465349197388, 0.14261098206043243, 0.6627069115638733, -0.12785738706588745, 0.12185368686914444, 0.17522579431533813, 0.2462369203567505, 0.9132152795791626, -0.08543837815523148, -0.11483229696750641, -0.5465390086174011, 0.07259727269411087, 0.4349778890609741, 0.05045555904507637, 0.23404516279697418, 0.5935162901878357, 0.231337308883667, 0.09601014852523804, 0.02859378419816494, 0.31815290451049805, -0.2815091013908386, -0.14733284711837769, -0.22477178275585175, -0.39916887879371643, -0.7264664173126221, -0.2851056158542633, -0.0860225111246109, -0.3346864581108093, -0.6465645432472229, 0.06029486656188965, -0.8946869969367981, -0.12244123965501785, -0.8557999730110168, -0.5627073645591736, 0.05137748643755913, -0.035005729645490646, -0.04521859437227249, -0.38535597920417786, -0.12598000466823578, -0.0704508051276207, 0.2724185585975647, 1.2306309938430786, -0.38863062858581543, 0.41953685879707336, 0.0040565491653978825, -0.09879601001739502, 0.29770150780677795, -0.14436987042427063, -0.026318412274122238, 0.40145814418792725, 0.15776994824409485, 0.5856562256813049, -0.5307712554931641, 0.04734222590923309, 0.5061877369880676, -0.22418895363807678, 0.3473253846168518, 0.15465810894966125, 0.37316617369651794, -0.12627370655536652, -0.608363151550293, -0.7231279611587524, -0.3236488401889801, 0.1821022927761078, -0.08546660840511322, -0.28898829221725464, -0.25515758991241455, -0.09170170873403549, 0.07845797389745712, -0.3055928647518158, 0.1732775717973709, -0.25090456008911133, -0.668237566947937, 0.007790291681885719, 0.1887841671705246, 0.5511549711227417, 0.11395630240440369, -0.3283299505710602, 0.12912867963314056, 0.27626991271972656, 0.316388338804245, -0.4085733890533447, -0.1828586459159851, -0.16647286713123322, 0.6242498755455017, -0.08581554144620895, 0.38812345266342163, 0.4768657088279724, -0.45543545484542847, -0.34088364243507385, -0.566116452217102, -0.2906564772129059, -0.14103414118289948, -0.4875040054321289, 0.1489942967891693, 0.14307938516139984, 0.21079006791114807, 0.22600969672203064, 0.13987459242343903, 0.031198611482977867, -0.7399093508720398, -0.1115911677479744, 0.09742098301649094, -0.5644035935401917, 0.8368263244628906, 0.1056477278470993, 0.4411604702472687, -0.0033306211698800325, 0.07888966798782349, -0.3606041967868805, -0.30823972821235657, -0.16142946481704712, 1.0720757246017456, -0.7371051907539368, 1.1187617778778076, -0.17060889303684235, -0.06351464241743088, 0.9461603760719299, 0.32857146859169006, -0.4011392891407013, -0.09188895672559738, -0.027346493676304817, 0.5167157053947449, -0.2982281446456909, -0.5711922645568848, -0.13507141172885895, -0.038885585963726044, -0.19670231640338898, -0.04593253135681152, 0.0485563687980175, 0.5059602856636047, -0.32833752036094666, -0.04543202370405197, 0.02610088139772415, 0.3370496928691864, -0.4517970383167267, -0.34784814715385437, 0.003022455843165517, -0.8471482992172241, -0.16043680906295776, 0.033918753266334534, -0.8302836418151855, 0.23122680187225342, 0.9007822275161743, 0.0750219076871872, 0.8716814517974854, 0.37846896052360535, 0.053538285195827484, 0.9242366552352905, -0.0072735873982310295, -0.07279523462057114, -0.33756983280181885, 0.2680339515209198, -0.21964383125305176, 0.14723694324493408, 0.48888838291168213, -0.03381959721446037, -0.19843654334545135, -0.11100950837135315, -0.0922941118478775, -0.024612877517938614, 0.1475801318883896, -0.7498438954353333, -0.26095104217529297, 0.026570765301585197, -0.1852400302886963, -0.32894763350486755, 0.29408422112464905, -1.4329253435134888, -0.08538488298654556, 0.3433172106742859, 0.2234088033437729, 0.38174867630004883, -0.504104495048523, 0.18212483823299408, 0.08624906092882156, -0.044474631547927856, -0.2995930314064026, 0.027350760996341705, -0.7059272527694702, -0.10581573843955994, -0.23040013015270233, -0.0404629185795784, 0.4135071933269501, -0.13039305806159973, -0.3832438290119171, -0.5214235186576843, -0.19337433576583862, 0.8651829957962036, 0.6931560635566711, 0.8796362280845642, -0.454653799533844, -0.7150371670722961, 0.11592205613851547, 0.08226584643125534, -0.4806162416934967, -0.014733845368027687, 0.6846991777420044, -0.4188246428966522, -0.1271246075630188, 0.2058323621749878, 0.4379661977291107, 0.9824002385139465, -0.06739678978919983, -0.7364805936813354, 0.053652323782444, -0.057964298874139786, -0.1666484773159027, -0.30188366770744324, -0.40762683749198914, -0.31458383798599243, 0.25797754526138306, -0.20395760238170624, -0.1838495433330536, 0.18871523439884186, 0.25115540623664856, -0.311978280544281, 0.6478580236434937, 0.32276421785354614, -0.08715113252401352, -0.07760424166917801, 0.13775178790092468, 0.09456921368837357, -0.19226814806461334, -0.17913001775741577, 0.18606460094451904, -0.5467270612716675, 0.6211110353469849, -5.880071640014648, 0.06797519326210022, 0.02076440118253231, -0.2861087918281555, -0.30755266547203064, -0.3223016858100891, 0.7453055381774902, -0.11615929752588272, 0.2483983039855957, 0.10528837889432907, 0.260606974363327, 0.2840321362018585, -0.1666182577610016, -0.14632733166217804, -0.2881770431995392, -0.011367757804691792, -0.10043066740036011, -0.5513277053833008, 0.5715612769126892, 0.27307161688804626, 0.7756004333496094, -0.15756484866142273, -0.03282436728477478, 0.44354352355003357, -0.1364242434501648, 0.059413302689790726, -0.7558149099349976, -0.08426667749881744, -0.19818060100078583, -0.6050730347633362, -0.09960716217756271, -0.47332963347435, 0.15108489990234375, -0.11399465054273605, 0.4987213909626007, 0.11267956346273422, -0.0001938791829161346, 0.23288290202617645, -0.1868603378534317, -0.5971617698669434, 0.32733651995658875, -0.06609858572483063, -0.47809627652168274, 0.14812639355659485, 0.34488287568092346, 0.22662274539470673, -0.03253045305609703, 0.5138828158378601, -0.61307692527771, 0.9116660356521606, 0.22256164252758026, -0.28643935918807983, 0.13068731129169464, 0.36739084124565125, 0.4589236080646515, 0.38291820883750916, -0.38855215907096863, 0.0442088320851326, -0.5005699992179871, 0.47746962308883667, -0.5039388537406921, -0.13037757575511932, -0.13188394904136658, -0.35056573152542114, 0.07335394620895386, 0.33133354783058167, -0.7083202004432678, -0.43281176686286926, 0.30611878633499146, -0.07862108945846558, 0.05779971554875374, 0.4169738292694092, 0.5967332124710083, -0.6842780709266663, 0.5968909859657288, -0.3527626097202301, 0.35418590903282166, 0.06215689331293106, 0.13265253603458405, 0.0355120450258255, -0.19239096343517303, 0.06811203807592392, -0.13943898677825928, -0.599963366985321, 0.01895379275083542, -0.2880215048789978, -0.16802933812141418, 0.4274294674396515, -0.2250087559223175, 0.3209337592124939, 0.3520383834838867, -0.11537887901067734, 0.26045578718185425, 0.6848615407943726, 0.21744120121002197, 0.3356892764568329, 0.5016502737998962, 0.7270399332046509, 0.7054198384284973, -0.05886847525835037, 0.5415129065513611, -0.21002197265625, -0.23925672471523285, -0.8431099653244019, -0.14534485340118408, 0.2110757827758789, -0.2818681597709656, 0.23246333003044128, 0.7054390907287598, -0.7046629190444946, 0.20917224884033203, 0.12220373749732971, -0.4120015501976013, -0.5006641745567322, 0.7353811860084534, -0.4783792197704315, -0.1840699464082718, 0.2740228474140167, 0.8780162334442139, -0.21693065762519836, 0.12848924100399017, 0.43589797616004944, -0.7393335103988647, 0.27724146842956543, 0.24671395123004913, 0.11292511969804764, 0.2575783133506775, 0.8593723773956299, -0.5785104036331177, -0.21663378179073334, 0.13865447044372559, 0.3527293801307678, -0.26871830224990845, 0.18582893908023834, 0.11725857853889465, -0.44483786821365356, -0.5106920599937439, 0.3653576672077179, 0.24487186968326569, -0.04285798221826553, 0.4659448266029358, -0.08227694034576416, -0.2352125346660614, -0.12809190154075623, 0.11556196212768555, 0.1912921816110611, -0.24201516807079315, 0.3180564343929291, -0.12019447982311249, -0.39019325375556946, 0.29110556840896606, -0.1294572651386261, -0.03974619135260582, -0.1953931599855423, -0.2760997414588928, 0.47438108921051025, 0.5650014281272888, 0.10128786414861679, 0.43898120522499084, -0.984245777130127, 0.427386075258255, 0.10520612448453903, -0.9007396697998047, 0.14786554872989655, -0.5876806974411011, 0.20049193501472473, -0.1923452913761139, -0.4187409579753876, 0.005003997590392828, 0.3293877840042114, -0.38997483253479004, -0.16076110303401947, -0.34284088015556335, 0.025276800617575645, 0.32232651114463806, -0.5568165183067322, -0.21209536492824554, -0.09963788092136383, -0.019502591341733932, 0.0730879083275795, 0.006600060500204563, -0.932386040687561, -0.22055619955062866, 0.06855670362710953, 0.24481715261936188, 0.5446716547012329, 0.16615718603134155, 0.06590698659420013, -0.3036783039569855, -0.23428189754486084, 0.22100341320037842, 0.05929988622665405, 0.01214507408440113, -0.5632022023200989, 0.5047730803489685, -0.0913708284497261, 0.02324087917804718, 0.24125947058200836, 0.32472842931747437, -0.69611656665802, 0.05770619958639145, 0.5478954911231995, -0.1887226402759552, 0.1900101602077484, 0.4954327344894409, 0.11980403959751129, -0.16810274124145508, 0.03859769552946091, -0.25344038009643555, -0.044169530272483826, -0.28832200169563293, -0.3502368927001953, 0.18080854415893555, 0.3812543749809265, -0.005794844124466181, -0.012641413137316704, 0.07468288391828537, -0.3494693636894226, -0.2735464870929718, 0.6321353316307068, 0.6942262649536133, -0.12504751980304718, -0.1407739371061325, -0.01835719682276249, -0.5490590333938599, 0.14109191298484802, 0.2652602791786194, -1.1081063747406006, 0.36679956316947937, 0.22627019882202148, -0.440422385931015, -0.05574316158890724, 0.013713587075471878, -0.02485276199877262, -0.25836795568466187, -0.5814858675003052, 0.10777701437473297, 0.5424383282661438, -0.008136210031807423, 0.4907819628715515, 0.36434072256088257, 0.8248741030693054, -0.6145093441009521, -0.19071060419082642, -0.045042894780635834, 0.612281858921051, 0.43077248334884644, -0.6155329346656799, -0.36497509479522705, 0.012137994170188904, 0.33052438497543335, -0.12408702075481415, 0.14755380153656006, 0.6419232487678528, 0.9420542120933533, -0.092887744307518, -0.09386604279279709, -0.434254914522171, -0.15527938306331635, 0.015473313629627228, -0.25554975867271423, 0.0893767699599266, 0.08406729996204376, -0.016381390392780304, 0.4303267002105713, 0.026643430814146996, 0.035988546907901764, -0.12405900657176971, 0.37026074528694153, 0.038724616169929504, 0.17559336125850677, -0.15703082084655762, 0.6764841675758362, 0.543895959854126, -0.13866537809371948, 0.4540834426879883, -0.35716962814331055, -0.05379576236009598, -0.260202556848526, 0.2558610737323761, -0.18430504202842712, -0.7600440979003906, 0.4877164661884308, -0.39545437693595886, 0.5352334380149841, -0.7618797421455383, 0.12071987986564636, -0.24010221660137177, -0.06563274562358856, -0.2525548040866852, -0.3920387923717499, -0.061097659170627594, -0.6572181582450867, -0.614431619644165, 0.06890646368265152, 0.23722366988658905, 0.18632085621356964, 0.021050551906228065, 0.027554117143154144, 0.11715942621231079, -0.5170599222183228, 0.47547096014022827, 0.1137639507651329, -0.186788409948349, 0.11222857236862183, 0.20466522872447968, 0.07394703477621078, -0.02366829290986061, -0.5974147319793701, 0.07277408987283707, -0.07157698273658752, -0.3979158103466034, 0.44873175024986267, -0.10218901932239532, -0.28314992785453796, 0.09270939230918884, -0.33926936984062195, -0.09406664222478867, 0.3537903428077698, 0.1956750899553299, 0.39053210616111755, 1.0390608310699463, 0.6600409746170044, -0.13353164494037628, -0.09896870702505112, 0.42916974425315857, 0.24545662105083466, -0.06379605829715729, 0.4694714844226837, 0.5289542078971863, 0.4441220164299011, 0.4665869474411011, -0.06886620819568634, 1.0462162494659424, 0.46369895339012146, -0.003990472294390202, 0.24554623663425446, -0.3663563132286072, -0.28740963339805603, -0.2713558077812195, 0.603367030620575, 0.009001866914331913, -0.24365606904029846, -0.01404678076505661, 0.23242507874965668, 0.40598297119140625, -0.19663141667842865, 0.23426158726215363, -0.4149731695652008, -0.10950938612222672, 0.3291577696800232, -0.5056310296058655, -0.5474424362182617, 0.21493177115917206, -0.4748758375644684, 0.3796094059944153, 0.31459569931030273, -0.414840430021286, -0.2883978486061096, 0.31806814670562744, -0.3339464068412781, -0.01041051559150219, -0.2788947522640228, 0.5566462278366089, 0.3432483375072479, -0.019910674542188644, 0.19538450241088867, 0.21935436129570007, 0.19845819473266602, -0.13217198848724365, -0.0758122056722641, 0.0206361785531044, -0.11647166311740875, 0.1746825873851776, 0.1678745448589325, -0.48222801089286804, -0.35346364974975586, 0.04757317155599594, 0.12569177150726318, 0.2946451008319855, -0.43341588973999023, 0.39137354493141174, 0.06232849135994911, -0.6841204762458801, -0.35058683156967163, -0.5800586342811584, -0.2654150128364563, -0.25144949555397034, 0.15920819342136383, -0.20079000294208527, 0.36618077754974365, -0.8123106956481934, -0.051873061805963516, 0.013987204991281033, 0.4248317778110504, -0.10250918567180634, -0.021365761756896973, 0.15288124978542328, 0.24888740479946136, 0.47352907061576843, 0.08829416334629059, 0.16595332324504852, -0.4212803542613983, 0.32546281814575195, -0.5155056715011597, 0.27638354897499084, -0.28812581300735474, -0.3349679708480835, -0.5516394972801208, 0.16905808448791504, 0.8831466436386108, 0.44082412123680115, -0.29959920048713684, 0.44095972180366516, 0.3067532479763031, 0.40113383531570435, 0.4096323847770691, -0.28891703486442566, -0.27751579880714417, -0.7112792730331421, -0.23449815809726715, -0.6147546768188477, 0.8867378830909729, 0.03698600083589554, -0.24350906908512115, -0.004883536137640476, 0.31230729818344116, 0.023250844329595566, -0.2025884985923767, 0.2991872727870941, -0.27276119589805603, 0.11807835102081299, -0.5423880815505981, 0.42090967297554016, -0.843184232711792, -0.022518236190080643, -0.014757787808775902, -0.37556949257850647, 0.040085569024086, -0.14333613216876984, 0.2924995422363281, -0.3561681807041168, 0.08755042403936386, 0.07778677344322205, 0.326020210981369, -0.2820713222026825, 0.03177225962281227, -0.6552519798278809, -0.35463616251945496, 0.13380998373031616, 0.24722367525100708, -0.5095461010932922, -0.16545936465263367, -0.03786754980683327, -0.21532921493053436, 0.21234844624996185, 0.013066704384982586, -0.4316976070404053, -0.15431855618953705, -0.10547150671482086 ]
The management of women who have a genetic predisposition for breast cancer requires careful planning. Women who have BRCA 1 and BRCA 2 mutations are at increased risk for breast cancer and for other cancers as well, particularly ovarian cancer. Screening, prophlyactic surgery, and chemoprevention are commonly utilized strategies in the management of these patients, and women may choose more than one of these strategies. No randomized prospective trials have assessed the impact of these strategies specifically in mutation carriers. All patients should be informed that screening, prophylactic surgery, and chemoprevention have the potential for harm as well as benefit.
[ 0.00761058647185564, 0.01368117518723011, -0.0019661844708025455, 0.012908648699522018, 0.020417779684066772, -0.012333476915955544, 0.010646438226103783, 0.013344813138246536, -0.013325070962309837, 0.005333338864147663, -0.01547305565327406, 0.006448442116379738, -0.003853883594274521, 0.01896153949201107, -0.05769834667444229, -0.006446653977036476, -0.01875942200422287, 0.029322728514671326, 0.008754024282097816, 0.009536472149193287, -0.01751532591879368, -0.017682861536741257, 0.010145469568669796, -0.0012618943583220243, -0.02495177462697029, 0.028310084715485573, -0.04656841605901718, -0.0004460092168301344, -0.010985552333295345, -0.03447501361370087, -0.006745714694261551, -0.003795340657234192, 0.011265029199421406, 0.008201958611607552, -0.002274171682074666, -0.02247135154902935, 0.002906985115259886, 0.013299059122800827, 0.05464635789394379, -0.0057466160506010056, 0.0012506237253546715, -0.017059560865163803, 0.006092998664826155, -0.01690831407904625, -0.006574577651917934, -0.01858058013021946, -0.006309720687568188, 0.019876884296536446, 0.01829598844051361, 0.010828552767634392, -0.010148052126169205, -0.03572991490364075, -0.0165108572691679, 0.00477827712893486, -0.006563642993569374, -0.01551089994609356, 0.01702866703271866, 0.004113295581191778, 0.022647839039564133, -0.020736418664455414, 0.014867221936583519, -0.027712807059288025, 0.005737587809562683, -0.0034047914668917656, 0.008931824006140232, -0.06701990962028503, 0.0599028654396534, 0.0011371821165084839, -0.015428872779011726, 0.002849230542778969, 0.030799325555562973, 0.013267643749713898, 0.004608013667166233, 0.0032702875323593616, -0.03845599666237831, -0.019954510033130646, 0.005515685770660639, -0.00434268219396472, 0.03716196119785309, 0.049718569964170456, -0.03569416701793671, 0.004893519449979067, -0.021453332155942917, 0.009833449497818947, 0.01293856743723154, -0.0004125172272324562, -0.01729055680334568, -0.0065648905001580715, -0.000260933768004179, 0.006365813314914703, 0.009994683787226677, 0.011803038418293, -0.03749693185091019, -0.03534019738435745, -0.05670877918601036, -0.028152018785476685, -0.014692243188619614, 0.0026536975055933, -0.02774188295006752, 0.015490978956222534, -0.011936508119106293, 0.0222576092928648, 0.010404612869024277, -0.02893623523414135, -0.002654572017490864, 0.011801857501268387, -0.006892654113471508, -0.014861688949167728, 0.05077667906880379, 0.01324138417840004, -0.02649690955877304, 0.007682876195758581, 0.01969643495976925, -0.00008153996895998716, 0.0005798083730041981, 0.002347724512219429, 0.01449338998645544, 0.03240159898996353, 0.02260253019630909, 0.017859192565083504, -0.028923042118549347, -0.0032169693149626255, -0.004038957878947258, 0.02160809561610222, -0.0025959343183785677, 0.0014831193257123232, 0.0038970313034951687, 0.010643430054187775, 0.019434837624430656, 0.009340665303170681, -0.010249121114611626, -0.0010619976092129946, -0.013294946402311325, -0.025255657732486725, 0.0035485532134771347, -0.0030285289976745844, -0.01403049100190401, -0.00630390178412199, 0.0034215119667351246, -0.002969229593873024, -0.004076950252056122, 0.008760014548897743, -0.0019395165145397186, 0.010387738235294819, 0.00047358893789350986, 0.0055976081639528275, 0.00022849533706903458, 0.00935882143676281, 0.001213975716382265, -0.013739222660660744, -0.026801034808158875, 0.0022347988560795784, -0.04535263404250145, -0.02260918729007244, 0.030165357515215874, 0.0004815421998500824, -0.01227047573775053, -0.004645222797989845, -0.003319241339340806, -0.010180171579122543, -0.014710268005728722, -0.02480947971343994, 0.0020345402881503105, 0.008419427089393139, 0.024123424664139748, -0.017647013068199158, 0.006086127832531929, 0.0024299295619130135, -0.010194161906838417, 0.008079448714852333, -0.012407999485731125, -0.007930552586913109, -0.012266391888260841, 0.0008773999870754778, 0.009028956294059753, 0.005949582904577255, 0.010432763025164604, 0.009868798777461052, -0.016774211078882217, 0.06628037989139557, -0.024699024856090546, 0.000983523204922676, -0.011143325828015804, 0.0011747786775231361, 0.0015906700864434242, -0.0026911981403827667, 0.009674742817878723, -0.006819895002990961, -0.026697713881731033, 0.009580759331583977, 0.02109421044588089, -0.0017872743774205446, -0.024069001898169518, 0.035670943558216095, -0.033230625092983246, 0.0028702635318040848, -0.01359856128692627, 0.019706256687641144, -0.005953582935035229, 0.015842853114008904, -0.003260232973843813, 0.009125372394919395, 0.00192627077922225, -0.02081400156021118, 0.004885472822934389, 0.0012234533205628395, -0.0022949944250285625, -0.022944163531064987, -0.003609148319810629, -0.009191715158522129, 0.021190933883190155, -0.01357016246765852, -0.0014604583848267794, -0.0035071405582129955, 0.012782631441950798, 0.020641883835196495, -0.005594654940068722, 0.003713771468028426, -0.02791130170226097, -0.009609324857592583, 0.004124633502215147, 0.016168564558029175, 0.020271331071853638, -0.012763649225234985, 0.02129603549838066, 0.0025117192417383194, -0.011070743203163147, 0.01308499276638031, 0.01295968797057867, 0.01484618242830038, -0.006586343515664339, -0.02885916270315647, -0.010832300409674644, 0.016365280374884605, -0.007738866843283176, -0.0037492939736694098, 0.01140035130083561, -0.007281707599759102, 0.011721051298081875, -0.018136823549866676, 0.0001322086900472641, 0.01441198494285345, 0.018667425960302353, 0.028807900846004486, 0.002767435275018215, -0.007109617814421654, 0.048193834722042084, 0.01613708585500717, 0.012217498384416103, -0.017603714019060135, 0.007301499601453543, -0.010097257792949677, 0.028040429577231407, 0.01433156244456768, 0.02218608558177948, 0.014765100553631783, -0.004522338509559631, 0.03141804039478302, 0.023027438670396805, -0.006442355457693338, 0.00947527214884758, 0.010288878343999386, -0.02097655087709427, -0.04135116934776306, -0.01358908973634243, 0.01640116237103939, 0.0072064949199557304, 0.026471860706806183, 0.022140944376587868, 0.02987038716673851, 0.015230504795908928, -0.008883824571967125, -0.0073197269812226295, -0.08098392933607101, -0.016292477026581764, 0.013956406153738499, -0.0034076636657118797, 0.013611191883683205, 0.0037813917733728886, -0.016006294637918472, 0.004379959776997566, -0.014854827895760536, -0.0106773367151618, 0.018586065620183945, 0.012527420185506344, -0.0023319944739341736, 0.01777617074549198, 0.004882450681179762, -0.009511834010481834, 0.003347543301060796, 0.0007417509332299232, -0.01530799176543951, -0.028777524828910828, 0.010357361286878586, 0.024887464940547943, 0.009206071496009827, 0.020458735525608063, -0.02094741351902485, 0.010887439362704754, -0.010203482583165169, -0.005727890878915787, 0.022399408742785454, -0.0032889647409319878, 0.010588525794446468, -0.026013804599642754, 0.00942588597536087, -0.011197341606020927, -0.00670971442013979, -0.0051191519014537334, -0.002118844073265791, -0.012623261660337448, -0.011525669135153294, 0.015298780985176563, -0.0006927032954990864, 0.006779612507671118, 0.014758260920643806, -0.007551412098109722, 0.012214244343340397, 0.028946060687303543, -0.0059402259066700935, 0.03172185644507408, 0.017024539411067963, -0.0003968698438256979, 0.0041673434898257256, 0.0019060535123571754, 0.0038885651156306267, 0.001098714186809957, -0.016707587987184525, -0.001410861499607563, -0.0004225778393447399, -0.013944568112492561, -0.013007931411266327, -0.023143261671066284, 0.036121465265750885, 0.007643812336027622, 0.03785944730043411, 0.028110045939683914, -0.006121870130300522, -0.0011553652584552765, 0.016247062012553215, -0.017557330429553986, -0.01697164587676525, 0.013270895928144455, 0.009981420822441578, -0.007087705656886101, 0.02328803390264511, -0.0021231051068753004, 0.020461782813072205, -0.004567177966237068, -0.015173206105828285, -0.011575683020055294, 0.02118617296218872, 0.008677844889461994, -0.01302573923021555, -0.010607916861772537, -0.018460677936673164, 0.022769685834646225, -0.01911604404449463, -0.0011721996124833822, 0.013687336817383766, 0.0037619026843458414, 0.013282360509037971, -0.018452847376465797, -0.0006628679111599922, 0.02784731797873974, -0.016690511256456375, 0.008986876346170902, 0.031553808599710464, -0.043960124254226685, 0.01279104221612215, 0.010741448029875755, 0.022737104445695877, 0.00846577063202858, -0.029944777488708496, 0.004813452251255512, -0.012424206361174583, -0.008893225342035294, -0.021171409636735916, 0.015962371602654457, 0.016726739704608917, -0.004730014596134424, -0.011735092848539352, -0.007949692197144032, -0.01780732162296772, -0.011086802929639816, -0.003524444531649351, 0.01679355651140213, 0.008925853297114372, 0.025754215195775032, 0.010740166530013084, 0.0009281137026846409, 0.0724816620349884, -0.012917259708046913, 0.009462072513997555, -0.01563912443816662, 0.003436136757954955, -0.007385563105344772, -0.017458628863096237, 0.008058873005211353, -0.024769609794020653, 0.002767416648566723, 0.011501191183924675, 0.0019079279154539108, 0.0099836066365242, -0.014809517189860344, -0.0008495049551129341, 0.009573141112923622, -0.024500297382473946, 0.002240285510197282, -0.0008159689605236053, 0.00401108805090189, -0.02057776227593422, -0.016004478558897972, -0.014214009046554565, -0.037557415664196014, 0.0007002120837569237, 0.012834321707487106, -0.014392068609595299, -0.008279573172330856, -0.014607561752200127, 0.004972092341631651, -0.010043781250715256, 0.003136232029646635, -0.006468857638537884, 0.0131837734952569, 0.004325078800320625, -0.018485182896256447, 0.00886473711580038, 0.01068047620356083, 0.001193355768918991, 0.004261219874024391, -0.01320909895002842, -0.014768354594707489, 0.011038247495889664, 0.009633613750338554, 0.007900489494204521, 0.00629093311727047, 0.010421007871627808, -0.005525930784642696, 0.010110374540090561, 0.0013619635719805956, -0.010501464828848839, -0.00009514996781945229, 0.008570228703320026, 0.003182589076459408, -0.027656134217977524, 0.01459327433258295, 0.03201930969953537, -0.017298873513936996, -0.008328208699822426, -0.013698293827474117, 0.0015146853402256966, -0.027701426297426224, 0.04064846783876419, -0.020203527063131332, 0.01880940981209278, -0.005849524401128292, -0.00018430734053254128, -0.009178418666124344, 0.01117885671555996, -0.01790894754230976, -0.0030579599551856518, 0.024116354063153267, -0.009508935734629631, -0.022189028561115265, -0.019310573115944862, 0.0013327444903552532, 0.006882957648485899, -0.0028313128277659416, 0.006355283781886101, -0.035460758954286575, -0.00849829614162445, -0.008038681000471115, -0.0002056322991847992, 0.017681367695331573, 0.03840309754014015, -0.004859013482928276, 0.02281387522816658, -0.07461101561784744, -0.012407928705215454, -0.019096076488494873, -0.009395542554557323, 0.006796780973672867, 0.002544949296861887, -0.013366641476750374, -0.020922735333442688, 0.024116061627864838, -0.0014177444390952587, -0.014682985842227936, -0.03395450860261917, -0.01928134635090828, -0.018861358985304832, 0.01334376260638237, 0.050268057733774185, -0.001312502659857273, -0.005766463000327349, -0.02512587234377861, 0.021087851375341415, 0.016201356425881386, 0.01320287398993969, 0.019988778978586197, -0.0049936226569116116, 0.003994510509073734, -0.08131130039691925, 0.010970018804073334, -0.005594681482762098, 0.009591475129127502, 0.010437974706292152, -0.013301489874720573, 0.008795245550572872, -0.009785554371774197, -0.013155290856957436, -0.017868075519800186, -0.008818418718874454, -0.003266396466642618, 0.012433230876922607, 0.010698477737605572, 0.020414134487509727, -0.01056266762316227, 0.019346987828612328, -0.008817772381007671, -0.01128926407545805, 0.009846186265349388, 0.023508649319410324, 0.004276626743376255, -0.010169798508286476, -0.008207665756344795, -0.015598045662045479, 0.01651996746659279, 0.005151228979229927, 0.011778315529227257, 0.001619468443095684, -0.022680962458252907, 0.009800167754292488, -0.019891947507858276, -0.010754662565886974, -0.030211322009563446, -0.0018999604508280754, -0.01317407377064228, -0.007489598356187344, 0.004781911615282297, 0.001572326640598476, 0.0025478661991655827, -0.0018195018637925386, 0.01358785293996334, -0.03871903568506241, -0.004966238513588905, 0.002064602915197611, 0.019150856882333755, 0.009345198050141335, -0.0005811325390823185, 0.016873594373464584, 0.02357790246605873, 0.005203962326049805, -0.009235329926013947, 0.007492443546652794, -0.003992007113993168, -0.017794974148273468, 0.005754734389483929, -0.008174977265298367, 0.002953355899080634, -0.008855339139699936, -0.0030563874170184135, -0.007399591617286205, 0.020502997562289238, -0.013123231008648872, 0.0710923969745636, 0.01551733072847128, 0.00489739840850234, -0.01959359087049961, -0.009449883364140987, 0.006790167186409235, -0.027344075962901115, -0.027445390820503235, -0.004222712013870478, 0.0016398056177422404, 0.027526434510946274, -0.002161554526537657, 0.003469723043963313, 0.017897669225931168, -0.006067823618650436, 0.005171408876776695, -0.017189309000968933, -0.012966977432370186, 0.005526898428797722, 0.016703207045793533, 0.017007630318403244, 0.014646700583398342, -0.023256639018654823, 0.013704073615372181, -0.007896495051681995, -0.016415324062108994, -0.03764113411307335, -0.01203840784728527, -0.011388539336621761, -0.0009708297438919544, -0.0005125412717461586, 0.00554914865642786, 0.004646936431527138, 0.019203951582312584, 0.011555351316928864, -0.001234252005815506, -0.0007689972408115864, -0.0030125859193503857, 0.014339542016386986, 0.004290582612156868, -0.03537259250879288, -0.010439201258122921, -0.0043645137920975685, -0.023321107029914856, 0.030998382717370987, 0.01353332120925188, 0.0034315669909119606, -0.0056884391233325005, 0.002880506217479706, 0.022121071815490723, 0.007376070134341717, 0.0010481252102181315, -0.02230733633041382, 0.00043008127249777317, 0.00938902422785759, -0.026569955050945282, -0.01893506571650505, 0.027794796973466873, 0.00003787083551287651, -0.007574182935059071, 0.04290713742375374, -0.014224152080714703, -0.00025047827512025833, -0.015357446856796741, -0.005276430398225784, -0.004421374760568142, 0.0208763238042593, -0.01849300041794777, 0.018779639154672623, 0.01821068674325943, 0.017826389521360397, -0.009364211931824684, 0.010475296527147293, -0.02162596769630909, 0.016002681106328964, 0.009446809068322182, 0.0025621154345571995, 0.0358562096953392, 0.005433396436274052, 0.013257130049169064, -0.017411787062883377, 0.012350820004940033, -0.02694030851125717, -0.006332241930067539, -0.028708096593618393, 0.019008155912160873, 0.020470045506954193, -0.025303084403276443, -0.009331895038485527, 0.009612714871764183, 0.03797265514731407, 0.016957813873887062, -0.0005820152582600713, 0.01031534280627966, 0.007880466990172863, 0.033784475177526474, 0.008989683352410793, 0.0065635754726827145, 0.006306043826043606, 0.010425166226923466, 0.00784957967698574, 0.0163281187415123, -0.042380448430776596, -0.005338193383067846, -0.023022957146167755, -0.007795377634465694, 0.03559383377432823, -0.007811178918927908, 0.023989036679267883, 0.020257242023944855, 0.01861065998673439, -0.002440384356305003, 0.02127753011882305, -0.0056748115457594395, 0.007819965481758118, -0.0008225708734244108, -0.006392338778823614, 0.014236991293728352, 0.023935243487358093, -0.01277821883559227, -0.01957303285598755, 0.004265575669705868, 0.00908931065350771, 0.026356568560004234, -0.013355671428143978, -0.013941237702965736, -0.01558639295399189, 0.01534463930875063, -0.041223328560590744, -0.020029576495289803, 0.004271136596798897, -0.030259601771831512, 0.0006954591372050345, 0.023114755749702454, 0.0006240350194275379, 0.014864934608340263, -0.008461465127766132, -0.000650476198643446, -0.009738701395690441, -0.010539374314248562, -0.01707802526652813, 0.010831153020262718, -0.0012806605082005262, 0.009882189333438873, 0.009839425794780254, -0.0028855260461568832, 0.0016436252044513822, 0.012830276973545551, 0.009091120213270187, -0.009015833958983421, 0.008376449346542358, 0.009764165617525578, 0.02345115877687931, -0.009708955883979797, -0.016437118873000145, 0.02283290959894657, 0.00003580551128834486, 0.02317844331264496, -0.011619886383414268, 0.0016156926285475492, -0.027335558086633682, -0.010416273027658463, -0.007213436532765627, -0.006515475455671549, 0.004232488572597504, 0.02905997261404991, 0.0012524953344836831, 0.0022185398265719414, -0.008399243466556072, 0.0007151137106120586, 0.021522801369428635, -0.018042346462607384, -0.02639400213956833, 0.008276416920125484, -0.03013232722878456, -0.010234193876385689, -0.02511594258248806, -0.03170718997716904, -0.008649204857647419, 0.005854479502886534, 0.012477686628699303, 0.00021110055968165398, 0.0067921048030257225, -0.010179311037063599, -0.01621052250266075, -0.006737581919878721, 0.004847295582294464, 0.009688002988696098, -0.004360316786915064, 0.026622213423252106, -0.00865465123206377, -0.008296828716993332, -0.003272324101999402, -0.001965593546628952, 0.010720085352659225, -0.010730493813753128, 0.03872821107506752, -0.0058011747896671295, -0.006802144460380077, -0.0032146605663001537, 0.00788632407784462, -0.009904833510518074 ]
[ 0.03626333549618721, 0.14598610997200012, -0.6185001730918884, -0.2551063895225525, 0.5099765658378601, 0.6329973340034485, 0.589472770690918, -0.5811880826950073, -0.3929840326309204, -0.5106862783432007, -0.07657473534345627, 0.5668769478797913, -0.05881863459944725, 0.15000911056995392, -0.6936290264129639, 0.8735052347183228, 0.6025766730308533, 0.5650811791419983, -0.018812596797943115, -0.47588643431663513, -0.4123142957687378, -0.548488438129425, 0.345562607049942, -0.26241129636764526, 0.10703486204147339, 0.03897073119878769, 0.41047656536102295, -0.010805645026266575, 0.08517502248287201, 0.1419983059167862, -0.03662010282278061, -0.11365474760532379, 0.15459778904914856, -0.34281620383262634, 0.02100135013461113, 0.09118357300758362, 0.33408159017562866, 0.27906250953674316, -0.3867953419685364, 0.03934449329972267, -0.7657679319381714, 0.036463070660829544, -0.13810040056705475, 0.5248129367828369, -0.11580625176429749, -0.496558278799057, -1.5584758520126343, 0.22657155990600586, 0.06319314241409302, 0.0073256902396678925, -0.10882557928562164, 0.061537522822618484, 0.5302097797393799, 0.20162612199783325, 0.07041645795106888, 0.1724545955657959, -0.33568185567855835, 0.04681834951043129, -0.4669143259525299, -0.16561754047870636, 0.06161085143685341, -0.12963859736919403, -0.08729316294193268, 0.22083167731761932, 0.3589968979358673, 0.22686630487442017, 0.07656700909137726, 0.020219124853610992, -0.45997461676597595, -0.40906989574432373, -0.3777810335159302, -0.25325703620910645, -0.01815630868077278, -0.14067336916923523, -0.5966762900352478, 0.26115646958351135, -0.12389282137155533, -0.8331623077392578, 0.3968120217323303, 0.14497970044612885, 0.12920069694519043, -0.13483169674873352, -0.14114175736904144, -0.1577613651752472, 0.7344744801521301, 0.1121559739112854, 0.23231105506420135, 1.1465380191802979, -0.2839300334453583, 0.289635568857193, 0.39733466506004333, -0.22162875533103943, 0.5816766619682312, 0.03975141793489456, 0.3091058135032654, 0.562164306640625, 0.7447725534439087, -0.002518054796382785, 0.24032677710056305, -0.3609684407711029, -0.28484487533569336, -0.11778184026479721, 0.2287740409374237, -0.38801321387290955, -0.6056402921676636, -0.48182034492492676, -0.04559389129281044, -0.460552453994751, -0.6139985918998718, 0.16398313641548157, -0.5364612340927124, 0.6172899007797241, -0.05660117790102959, -0.09825219213962555, -0.5902000665664673, 0.5376826524734497, 0.3062880039215088, 0.22292038798332214, 0.2656658887863159, 0.17342950403690338, 0.16763076186180115, 0.5646596550941467, -0.2152203470468521, 0.22598472237586975, 0.10066120326519012, 0.10948847979307175, 0.6835123300552368, 0.18256740272045135, -0.14374779164791107, -0.1844567060470581, -0.1585632711648941, 0.29020142555236816, -0.2870349884033203, -0.10176711529493332, -0.1700659841299057, -0.11754772067070007, -0.1321030855178833, 0.2287592589855194, 1.1753472089767456, 0.06557051092386246, -0.24058246612548828, -0.14995019137859344, -0.03974071517586708, 0.06436958909034729, 0.39501723647117615, -0.12746384739875793, 0.12221567332744598, 0.08388952910900116, -0.35090968012809753, 0.2561298608779907, 0.14414244890213013, 0.14824597537517548, -0.21536396443843842, -0.31049901247024536, -0.5111685395240784, 0.7622286081314087, 0.2505667209625244, -0.5734291076660156, -0.20368869602680206, 0.18464016914367676, 0.31199631094932556, -0.015999890863895416, -0.3019298315048218, 0.07204827666282654, 0.7065176367759705, -0.36068758368492126, 0.1015358567237854, 0.8572858572006226, 0.21788500249385834, -0.11116810888051987, -0.6883562207221985, 0.11199718713760376, 0.011601733043789864, -0.9965945482254028, 0.54837965965271, 0.3727135956287384, -0.041763439774513245, 0.3399736285209656, 0.1888648420572281, 0.2519519627094269, -0.6338974833488464, 0.43259140849113464, -0.08873065561056137, -0.49209505319595337, 0.4857487082481384, -0.24051029980182648, 0.07896836847066879, 0.0072391522116959095, 0.1495845764875412, 0.17717647552490234, -0.7334802746772766, -0.4525615870952606, 0.8496485352516174, -0.08005066215991974, 0.8531831502914429, -0.10943512618541718, -0.34944477677345276, 1.707496166229248, -0.38894152641296387, -0.30646008253097534, 0.08481813967227936, 0.01028630044311285, -0.10654455423355103, -0.01301016379147768, -1.1829715967178345, 0.18640276789665222, 0.26544710993766785, -0.1737315058708191, -0.21859808266162872, 0.3339734375476837, 0.028491033241152763, -0.4505748152732849, -0.10599205642938614, -0.11027619242668152, 0.1900440752506256, 0.1309850513935089, -0.030061451718211174, -0.030962686985731125, 0.12085273861885071, 0.058083675801754, 0.6364069581031799, -0.4117312431335449, 0.3517407774925232, 0.633690595626831, 0.11225235462188721, 0.2057245373725891, 0.32780349254608154, -0.043314818292856216, 0.6607962846755981, -0.0907982736825943, 0.5183135867118835, 0.22753483057022095, 0.12879012525081635, -0.3539552092552185, -0.21425515413284302, 0.40417593717575073, -0.307134747505188, -0.057675283402204514, -0.0440017506480217, -0.20012429356575012, -0.04454081133008003, 0.39271828532218933, -0.25602787733078003, 0.8142061233520508, 0.15389098227024078, -0.24014808237552643, -0.4144125282764435, 0.08215489238500595, -0.6728435158729553, -0.19727468490600586, -0.011344416998326778, 0.5020142197608948, 0.33917224407196045, -0.6340412497520447, 0.04352086782455444, -0.3444233536720276, -0.06006837263703346, -0.19213762879371643, 0.31129369139671326, -0.5272971391677856, 0.22451114654541016, 0.4386424422264099, 0.22387266159057617, 0.13314120471477509, 0.06472714990377426, -0.1698770821094513, -0.33662712574005127, -0.5785662531852722, 0.422494113445282, 0.13450995087623596, 0.412753701210022, -0.01252101082354784, -0.9681928753852844, -0.08682476729154587, -0.22290728986263275, -0.6328514814376831, -0.3196418285369873, 0.6658179759979248, -0.6175342798233032, -0.23069190979003906, 0.17766810953617096, 0.8481847047805786, 0.928404688835144, -0.4918200373649597, -0.5401976704597473, -0.11066454648971558, 0.46732231974601746, -0.21762897074222565, -0.6317140460014343, 0.3454740643501282, -0.5917760729789734, 0.2062332034111023, -0.3052854835987091, -0.45524176955223083, 0.8331636786460876, 0.23522141575813293, -0.5825286507606506, 0.6334162950515747, 0.5668142437934875, 0.17711707949638367, -0.07144784927368164, -0.058679744601249695, 0.25539469718933105, -0.15352658927440643, -0.40671542286872864, -0.212737038731575, -0.35333529114723206, -0.3139928877353668, -5.831905841827393, -0.4986092448234558, -0.2781177759170532, -0.10022476315498352, -0.38428932428359985, -0.21181771159172058, 0.8706259727478027, -0.09764482825994492, 0.015647830441594124, 0.3911633789539337, 0.5119279026985168, 0.5976253747940063, 0.16627325117588043, -0.1860538125038147, -0.05386314168572426, 0.13771264255046844, 0.32626447081565857, -0.429238885641098, 0.08317285031080246, -0.23377731442451477, 0.6679004430770874, 0.10530985891819, -0.539359986782074, 0.8634108901023865, 0.3542726933956146, 0.3025873303413391, -0.4290049076080322, 0.13875305652618408, -0.6751115918159485, -0.39351215958595276, 0.5009801983833313, 0.043474748730659485, -0.4238628149032593, 0.25453299283981323, -0.012621922418475151, 0.3205735683441162, 0.05873429402709007, 0.0074790893122553825, -0.1396537721157074, -0.42006805539131165, 0.38248851895332336, 0.3853320777416229, -0.4146001636981964, 0.24168609082698822, 0.2563256621360779, -0.2091318815946579, 0.40770792961120605, -0.037114616483449936, 0.021212169900536537, 0.9399405717849731, 0.24636061489582062, -0.22021812200546265, 0.4159237742424011, 0.3262816071510315, 0.12414176017045975, 0.2690739035606384, -0.16285814344882965, 0.2079479843378067, -0.1914205402135849, -0.0816095694899559, -0.2924118638038635, -0.492189884185791, 0.29367032647132874, -0.5817083716392517, 0.15310268104076385, -0.04950568452477455, -0.5425288081169128, -0.6513684391975403, 0.023041103035211563, -0.08515091240406036, 0.03303341567516327, 0.5258709192276001, 0.3371576964855194, -0.5191848874092102, 0.2875632643699646, -0.7256679534912109, -0.007773804944008589, 0.3071882724761963, -0.030820269137620926, -0.6905745267868042, -0.09998726099729538, -0.2705039381980896, 0.26958197355270386, -0.5035874247550964, 0.008814580738544464, -0.2449534386396408, 0.07401879876852036, 0.07313910126686096, -0.22512376308441162, 0.42051589488983154, 0.4386889636516571, -0.15691836178302765, 0.20466266572475433, 0.5656424164772034, 0.4120028018951416, 1.274211049079895, 0.29463642835617065, -0.035632066428661346, 0.08640474081039429, -0.300961434841156, 0.2941281497478485, -0.11690353602170944, -0.3218001425266266, -0.9066932201385498, -0.3408711552619934, -0.059903621673583984, -0.45821547508239746, -0.23705445230007172, 0.7898805141448975, -1.132879614830017, 0.16078901290893555, 0.10960375517606735, 0.04944271966814995, -0.6785677075386047, 0.4268887937068939, -0.22858352959156036, -0.3205186426639557, 0.07056531310081482, 0.44836241006851196, -0.007264314219355583, 0.14418825507164001, 0.07314528524875641, -0.47705215215682983, 0.4083603322505951, 0.19985716044902802, -0.633211076259613, 0.5147541761398315, 0.778916597366333, -0.6896948218345642, 0.2991257905960083, 0.32046711444854736, 0.27020806074142456, -0.6575793623924255, -0.27531155943870544, 0.16378605365753174, 0.06684599071741104, -0.1561061590909958, 0.7500087022781372, -0.46390727162361145, 0.20150278508663177, -0.024602491408586502, 0.07548894733190536, -0.5915829539299011, 0.01936892420053482, -0.47614651918411255, 0.07901030778884888, -0.2911485433578491, 0.04337407276034355, -0.12332835048437119, 0.24828478693962097, -0.3669608235359192, -0.06297872215509415, 0.2496265023946762, -0.3439881503582001, 0.013023528270423412, 0.0021886664908379316, 0.44002920389175415, 0.3983475863933563, 0.015419638715684414, -0.7492170929908752, -0.4214555025100708, 0.04178660362958908, -1.0245592594146729, -0.2473287433385849, 0.12576255202293396, -0.27098914980888367, -0.07961258292198181, -0.3585134446620941, -0.39443111419677734, 0.7533627152442932, 0.11837397515773773, -0.4554273188114166, -0.3023097813129425, -0.25511279702186584, 0.3613467514514923, -0.022600853815674782, 0.09562289714813232, 0.28391921520233154, -0.47156432271003723, -0.09366970509290695, 0.12302951514720917, -0.938095211982727, 0.07165642082691193, 0.2600990831851959, 0.5321767330169678, 0.25918781757354736, 0.012437218800187111, -0.4159535765647888, -0.37947264313697815, -0.17315946519374847, 0.004831752739846706, -0.07798212021589279, 0.5029006004333496, -0.08103781938552856, 0.07166612893342972, 0.07972247153520584, -0.09577777236700058, 0.5510108470916748, -0.12604649364948273, 0.015904737636446953, 0.18339182436466217, 0.4745277762413025, -0.44816258549690247, 0.3000350296497345, 0.46603167057037354, -0.5648627281188965, 0.20248518884181976, -0.08236580342054367, -0.6637440323829651, 0.14367720484733582, -0.3525477647781372, 0.016886668279767036, 0.2667786478996277, 0.3559934198856354, -0.41992488503456116, 0.015138547867536545, -0.018290860578417778, -0.30854904651641846, -0.2634897232055664, 0.21265333890914917, 0.36810651421546936, -0.796342670917511, -0.23956426978111267, 0.23798048496246338, -0.322002649307251, -0.07149775326251984, 0.06575261056423187, -1.1278517246246338, 0.3701700270175934, 0.40623098611831665, -0.4017842411994934, -0.3098975718021393, -0.15147268772125244, -0.1497933566570282, 0.02821694128215313, -0.3268429934978485, -0.1010289117693901, 0.3514733612537384, 0.1932269185781479, -0.05263456702232361, 0.07011646777391434, 0.05533071979880333, -0.5660377144813538, -0.32416436076164246, -0.0914992094039917, -0.2052597552537918, 0.004078689496964216, -0.865257978439331, -0.4588625431060791, 0.6681373715400696, 0.3725437819957733, -0.31983548402786255, 0.22705848515033722, -0.31173449754714966, 0.13601700961589813, 0.05645045265555382, -0.05921817570924759, -0.44336119294166565, -0.10306812077760696, 0.48978161811828613, -0.12934748828411102, -0.240275576710701, -0.48613685369491577, -0.34285789728164673, 0.7083659172058105, 0.1316884309053421, -0.31767070293426514, -0.9878856539726257, -0.035974904894828796, -0.4530784487724304, 0.18329177796840668, -0.3070719540119171, 0.7260364294052124, 0.13667963445186615, 0.2313298135995865, 0.24654147028923035, -0.022256262600421906, -0.25086161494255066, -0.2316547930240631, 0.4198409914970398, -0.06791990250349045, -0.5173776745796204, 0.25068551301956177, -0.06380099058151245, 0.8003525137901306, -0.9165194034576416, 0.49270737171173096, -0.12881046533584595, -0.5517151951789856, -0.5807348489761353, 0.16636261343955994, 0.16857080161571503, -0.6053775548934937, -0.2191554605960846, 0.05654049664735794, 0.2679818570613861, -0.06846994161605835, 0.3711635172367096, -0.1292639523744583, -0.4824736714363098, -0.38795995712280273, 0.28498491644859314, 0.359585702419281, 0.04770742356777191, 0.1547536849975586, 0.6834625005722046, 0.0773516595363617, 0.018732892349362373, -0.1722833514213562, 0.40744659304618835, -0.1754201352596283, -0.24652454257011414, 0.8786248564720154, 0.9591650366783142, -0.6753490567207336, 0.08062576502561569, -0.3656243681907654, -0.3591662049293518, 0.5672194957733154, -0.3360990881919861, 0.04276217147707939, 0.055698368698358536, 0.6743428111076355, -0.07495202124118805, -0.3191041350364685, 0.6612147092819214, -0.030581878498196602, 0.9889103770256042, 0.4869464039802551, 0.329617440700531, 0.2176727056503296, 0.990985631942749, 0.09155633300542831, 0.06282514333724976, 0.18999019265174866, 0.14964565634727478, -0.05531539395451546, -0.4467529058456421, -0.06403464078903198, 0.18352849781513214, 1.0465872287750244, 0.045616354793310165, 0.09359633177518845, 0.10334555059671402, 0.3644438683986664, 0.43322521448135376, 0.422482430934906, 0.21545690298080444, -0.3562212884426117, -0.36301305890083313, 0.061541847884655, -0.2887123227119446, -0.38810092210769653, 0.3095368444919586, -0.03369889035820961, 0.35373884439468384, 0.301864355802536, -0.1890079379081726, -0.19817407429218292, 0.14262232184410095, 0.1356211155653, -0.3186194896697998, -0.7476946711540222, 0.03297809883952141, -0.019769655540585518, -0.48880910873413086, 0.6976670622825623, 0.1230296716094017, 0.13526038825511932, -0.2992396354675293, 0.13855883479118347, 0.11328890174627304, -0.41619858145713806, 0.02542242780327797, 0.4006570875644684, -0.5183941721916199, 0.3674165606498718, -0.2639426589012146, -0.11907308548688889, 0.28622832894325256, 0.047697488218545914, 0.41964536905288696, -0.2721223533153534, -0.46286988258361816, -0.3682362139225006, -0.3341161906719208, -0.5015750527381897, -0.09628704190254211, 0.30719444155693054, 0.11256752163171768, 0.1727839559316635, -0.21370559930801392, -0.18225465714931488, 0.2120930552482605, 0.3090585470199585, -0.13295438885688782, 0.21521151065826416, 0.5928173661231995, 0.39489835500717163, 0.4000946283340454, -0.26560646295547485, 0.4150278866291046, -0.21012619137763977, 0.7850154042243958, -0.41444528102874756, 0.385262131690979, -0.48581716418266296, 0.15485136210918427, -0.6212577819824219, -0.05534164234995842, 0.5272440314292908, 0.5816312432289124, -0.0959448590874672, 0.2538292407989502, -0.05061187967658043, 0.0268479622900486, 0.48148709535598755, -0.5113367438316345, -0.44265785813331604, -0.14489860832691193, -0.05397379398345947, -0.5708050727844238, 0.6045054197311401, 0.19598637521266937, -0.5350590348243713, -0.3767877519130707, 0.03837636485695839, 0.3325980305671692, -0.09996301680803299, 0.5504816770553589, -0.3712209165096283, -0.020171524956822395, -0.5745889544487, 0.18582141399383545, -0.4190487861633301, -0.11050034314393997, -0.1448718160390854, -0.07048389315605164, 0.6372447609901428, -0.17759989202022552, -0.39711692929267883, -0.40719369053840637, 0.2172405868768692, 0.4292978048324585, 0.07004459947347641, -0.05418672412633896, -0.3137202262878418, -0.18273380398750305, -0.25145772099494934, 0.39257848262786865, -0.3780052363872528, -0.2118072509765625, -0.003048851853236556, -0.013822279870510101, -0.1284407675266266, -0.16144855320453644, -0.07396542280912399, -0.6496341228485107, -0.6662412285804749, 0.1135612204670906 ]
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease, with astrocytes implicated as contributing substantially to motor neuron death in familial (F)ALS. However, the proposed role of astrocytes in the pathology of ALS derives in part from rodent models of FALS based upon dominant mutations within the superoxide dismutase 1 (SOD1) gene, which account for <2% of all ALS cases. Their role in sporadic (S)ALS, which affects >90% of ALS patients, remains to be established. Using astrocytes generated from postmortem tissue from both FALS and SALS patients, we show that astrocytes derived from both patient groups are similarly toxic to motor neurons. We also demonstrate that SOD1 is a viable target for SALS, as its knockdown significantly attenuates astrocyte-mediated toxicity toward motor neurons. Our data highlight astrocytes as a non-cell autonomous component in SALS and provide an in vitro model system to investigate common disease mechanisms and evaluate potential therapies for SALS and FALS.
[ 0.007893050089478493, -0.0066207405179739, -0.018794549629092216, 0.007078045979142189, 0.000046062516048550606, -0.008435310795903206, 0.010423559695482254, 0.003765963949263096, -0.010077869519591331, 0.010404233820736408, -0.00652301637455821, -0.0007739576976746321, -0.001012514578178525, 0.03412735462188721, 0.02709244005382061, 0.014768690802156925, -0.032429419457912445, 0.011039137840270996, 0.010584837757050991, -0.013146860525012016, 0.0340326763689518, -0.01661418005824089, 0.010154773481190205, 0.011079801246523857, -0.010123886168003082, -0.019151996821165085, 0.04176436364650726, -0.011137772351503372, 0.025724776089191437, 0.034934915602207184, -0.0009500462329015136, -0.006732568144798279, -0.0066751837730407715, -0.012798028066754341, 0.009970074519515038, -0.011725218966603279, -0.0008532507927156985, 0.014998776838183403, 0.030579136684536934, -0.0050051454454660416, 0.01772422343492508, -0.01544930785894394, 0.0073072039522230625, 0.008945787325501442, -0.008157452568411827, -0.004202295560389757, -0.001087095821276307, -0.0005959048867225647, -0.01239619217813015, 0.003945653326809406, -0.008723074570298195, -0.01216714084148407, -0.018780041486024857, 0.013788183219730854, -0.006087402813136578, -0.015665395185351372, 0.018089091405272484, 0.008297469466924667, 0.0075789326801896095, 0.04899991303682327, 0.0030908461194485426, -0.011901463381946087, 0.012384120374917984, 0.0016097207553684711, 0.0031745568849146366, -0.06706203520298004, 0.041947949677705765, 0.018360642716288567, -0.006562437862157822, -0.0013992935419082642, -0.02473008632659912, 0.01190541684627533, 0.019201749935746193, -0.019699839875102043, -0.04218515008687973, -0.005817390978336334, -0.01039685495197773, -0.0009464472532272339, -0.003783767344430089, 0.024576153606176376, 0.010341201908886433, -0.010499422438442707, -0.010870140977203846, 0.0026124538853764534, 0.011945371516048908, 0.009765849448740482, -0.026010839268565178, -0.009960697963833809, 0.012356828898191452, -0.019658975303173065, 0.023072220385074615, -0.004490465857088566, -0.05139271169900894, 0.015256254002451897, 0.01670764572918415, -0.01910526305437088, -0.01999416947364807, 0.012948653660714626, 0.03148578107357025, -0.019315658137202263, -0.0031617311760783195, 0.020580744370818138, 0.016145925968885422, -0.008274471387267113, -0.028808865696191788, 0.013056110590696335, 0.031609270721673965, 0.0015389067120850086, 0.03135254234075546, 0.013523810543119907, -0.005933844484388828, 0.005735456012189388, -0.012481548823416233, 0.048622194677591324, 0.027640027925372124, 0.030675726011395454, -0.005084258504211903, 0.005189007148146629, 0.008844676427543163, -0.03566485643386841, -0.003918584436178207, 0.01835387945175171, 0.0006776419468224049, 0.008071903139352798, 0.0042563993483781815, 0.002761240117251873, 0.011952674016356468, -0.011289769783616066, 0.02199162170290947, 0.0030027474276721478, -0.00560410600155592, 0.003391232807189226, -0.004610516596585512, -0.020356949418783188, -0.006301843095570803, 0.0008099679835140705, -0.0033105185721069574, 0.02384834922850132, -0.004332471638917923, -0.03390483558177948, -0.010962559841573238, 0.010643675923347473, 0.009991234168410301, 0.014212220907211304, -0.006208823062479496, 0.0037506031803786755, 0.00749116949737072, 0.010998822748661041, -0.007165280636399984, -0.004970761016011238, 0.00027215504087507725, -0.015444017946720123, -0.0056059337221086025, -0.022544216364622116, 0.026157692074775696, 0.029665507376194, -0.0044077299535274506, -0.020092137157917023, -0.0013016704469919205, 0.0035081023816019297, -0.007702776696532965, -0.004471913445740938, 0.01872413605451584, 0.008085571229457855, -0.0009053866378962994, 0.008793128654360771, -0.006151421461254358, -0.015118337236344814, -0.0011182110756635666, 0.006118047516793013, -0.0002587497001513839, -0.010214272886514664, 0.02142932265996933, 0.01431574858725071, -0.03455135598778725, 0.00523916631937027, 0.041797835379838943, 0.008094795979559422, -0.021974418312311172, 0.06688257306814194, 0.03982779011130333, 0.052268192172050476, 0.0017523884307593107, -0.017071204259991646, 0.029862353578209877, 0.004623260349035263, -0.013330431655049324, -0.010864214040338993, -0.005415593273937702, 0.01288619451224804, -0.0260976143181324, 0.023581042885780334, 0.009190067648887634, 0.012867112644016743, 0.000593201257288456, 0.004393506795167923, -0.016412632539868355, 0.0046974411234259605, 0.0029719590675085783, -0.00429846066981554, -0.0009943628683686256, -0.015906408429145813, 0.036188263446092606, -0.0034213014878332615, -0.01095980778336525, 0.01831987127661705, 0.008539886213839054, -0.03268606588244438, 0.02050838991999626, 0.010191349312663078, 0.019239043816924095, -0.016292646527290344, -0.010415757074952126, -0.007493342272937298, -0.005099526606500149, -0.02051658183336258, 0.004051153548061848, 0.009985927492380142, 0.0029831165447831154, -0.008909299038350582, -0.00040491740219295025, -0.0079203424975276, -0.00875222310423851, -0.010577699169516563, 0.02020932361483574, -0.0007590176537632942, -0.001905384473502636, 0.010115793906152248, -0.0015469591598957777, 0.0065422458574175835, -0.002392682246863842, -0.010695762932300568, -0.013927135616540909, -0.0007290290668606758, 0.03921341896057129, -0.010153278708457947, 0.011401099152863026, -0.013359065167605877, 0.018846895545721054, -0.013206357136368752, -0.017473801970481873, -0.0025959813501685858, 0.027437904849648476, -0.010425436310470104, 0.025464117527008057, -0.007419457659125328, 0.0015533939003944397, -0.004192606545984745, 0.016517624258995056, -0.04564470052719116, 0.009627873077988625, -0.0021719227079302073, -0.005869584158062935, 0.008553514257073402, 0.013380298390984535, 0.00038677267730236053, 0.03470028564333916, -0.034117043018341064, 0.023378930985927582, -0.003964373841881752, 0.006754773668944836, 0.009370889514684677, 0.0004658850375562906, 0.021269094198942184, 0.0022627529688179493, -0.0018564024940133095, 0.007982124574482441, 0.01044271420687437, -0.0037889345549046993, -0.02472337707877159, 0.008172281086444855, -0.0004975372576154768, 0.00531349703669548, -0.08127545565366745, -0.01250857301056385, -0.016554322093725204, 0.06548433750867844, 0.007523201406002045, 0.04301685094833374, -0.0005848144646733999, 0.004486604128032923, -0.010508295148611069, 0.005645060911774635, 0.02545098587870598, -0.0021543377079069614, -0.015400966629385948, -0.03642687946557999, 0.0249176025390625, -0.005009078420698643, 0.006111690308898687, 0.01205519400537014, 0.004445842932909727, -0.02763812430202961, 0.025203416123986244, -0.021130191162228584, 0.03705930709838867, -0.013614950701594353, -0.021203676238656044, -0.008591242134571075, 0.004348236136138439, -0.015618554316461086, 0.008892223238945007, 0.010836734436452389, -0.006386402994394302, 0.011273736134171486, 0.0075091165490448475, 0.00370178185403347, 0.0024950155057013035, 0.02351657673716545, -0.01830994337797165, -0.0220146756619215, 0.00471589295193553, 0.040808819234371185, -0.023155998438596725, 0.03902240842580795, 0.006931683048605919, 0.002104358747601509, 0.014816772192716599, -0.007684225216507912, 0.0024452898651361465, -0.021939996629953384, 0.01800253987312317, -0.00799611397087574, 0.00283826794475317, 0.002693631686270237, 0.020620036870241165, 0.01540970616042614, -0.01995009556412697, 0.005487889517098665, -0.02520522102713585, 0.008524038828909397, -0.012703471817076206, -0.008500058203935623, -0.010696200653910637, 0.006182556971907616, -0.005680224858224392, 0.030439050868153572, -0.0012559425085783005, -0.002187964506447315, 0.017930738627910614, 0.02022944577038288, -0.025305937975645065, -0.00935276597738266, -0.014911467209458351, 0.0004984957631677389, -0.006904160603880882, -0.01147807389497757, -0.026059865951538086, -0.00486124400049448, -0.005608424078673124, -0.0022014514543116093, -0.040308285504579544, -0.013282382860779762, -0.002517357235774398, 0.001033174223266542, -0.033739201724529266, -0.0024337670765817165, -0.011004697531461716, -0.01718374341726303, 0.00755644915625453, 0.0252656452357769, 0.013405714184045792, -0.021481897681951523, 0.031306348741054535, 0.006130424793809652, 0.002679415512830019, 0.0145950298756361, -0.016024047508835793, -0.0018579608295112848, 0.003878664691001177, -0.01784556359052658, 0.006140398792922497, 0.00856563076376915, -0.0441250316798687, -0.001853418885730207, 0.015443644486367702, -0.004936866462230682, -0.020457321777939796, 0.018779154866933823, 0.027091318741440773, 0.013483190909028053, 0.013648423366248608, -0.0012952991528436542, -0.01588324084877968, 0.013251077383756638, -0.005675680004060268, 0.0002967086620628834, 0.01743239350616932, -0.0025027403607964516, -0.013508421368896961, -0.008176418021321297, 0.07203067094087601, 0.01617700792849064, 0.006590530276298523, -0.009152600541710854, 0.012047446332871914, -0.037821270525455475, -0.032689522951841354, 0.012514594942331314, -0.04391714185476303, -0.00037859578151255846, 0.011445234529674053, 0.002660839818418026, -0.03160059079527855, -0.02020309492945671, -0.011393452994525433, -0.004257178865373135, 0.00825461745262146, 0.0017036134377121925, -0.00585843063890934, 0.008248122408986092, -0.00017749331891536713, -0.007925624027848244, -0.011739916168153286, -0.0023648389615118504, 0.017280422151088715, -0.018987808376550674, -0.0038229371421039104, -0.012547975406050682, -0.024698231369256973, 0.012217430397868156, -0.010955767706036568, 0.029356107115745544, -0.006225348450243473, -0.00192213524132967, -0.001245962455868721, -0.017823252826929092, 0.02059245854616165, 0.01387746911495924, 0.023047354072332382, 0.0036021657288074493, 0.001972905360162258, -0.01636786386370659, -0.011154561303555965, 0.02846880815923214, -0.0034740129485726357, -0.020379047840833664, 0.004704627208411694, -0.006686546839773655, -0.0005106435855850577, -0.007127774879336357, -0.0070839496329426765, -0.009727592580020428, 0.007507343776524067, 0.001326875644735992, 0.022191200405359268, -0.025399532169103622, 0.01618621125817299, 0.00505537074059248, -0.01101918425410986, -0.043577056378126144, 0.01201607845723629, 0.009609496220946312, 0.014515362679958344, 0.0017307200469076633, 0.002089928602799773, -0.007873672991991043, 0.0004844246432185173, 0.0001211708877235651, -0.027573900297284126, -0.00876743346452713, 0.016254212707281113, 0.010970493778586388, -0.011964274570345879, -0.034387942403554916, -0.049346234649419785, 0.016660470515489578, -0.0036054998636245728, 0.01775672473013401, 0.03617769107222557, -0.02590024098753929, -0.01357640977948904, -0.0008175992406904697, 0.03455185890197754, -0.011395981535315514, -0.019255535677075386, 0.003106174524873495, -0.0039042928256094456, -0.07426270097494125, -0.02889036387205124, -0.0027379959356039762, -0.007681121584028006, -0.024307623505592346, -0.01285163126885891, -0.003967278636991978, -0.016536105424165726, -0.007919328287243843, -0.006062960252165794, 0.005992881953716278, -0.007534785196185112, 0.0193646103143692, 0.0239595714956522, 0.010820938274264336, -0.0007946719415485859, -0.019589969888329506, -0.0029024009127169847, -0.018889280036091805, 0.012132253497838974, 0.005696227308362722, 0.014098891988396645, -0.03435232862830162, 0.01007983647286892, -0.00818552728742361, -0.08081386238336563, -0.00411980552598834, -0.006270132027566433, -0.025996357202529907, 0.0124834468588233, -0.01580728590488434, 0.017624985426664352, -0.018194135278463364, -0.012706361711025238, -0.01663079857826233, -0.03296749293804169, -0.01429549790918827, -0.01790393702685833, 0.012988222762942314, -0.002779412781819701, -0.008295012637972832, 0.03506961837410927, 0.02514994889497757, 0.00853242352604866, 0.030796905979514122, 0.005299773532897234, 0.030530642718076706, -0.007629071827977896, 0.011085468344390392, -0.015656419098377228, -0.02226123958826065, -0.015018230304121971, 0.011670413427054882, 0.009294037707149982, 0.005125206429511309, 0.019868019968271255, -0.00808483362197876, -0.02201450616121292, -0.004219178110361099, -0.046384163200855255, -0.020999977365136147, -0.013328414410352707, -0.00662605743855238, -0.003839773591607809, 0.014502601698040962, -0.010538710281252861, -0.029889728873968124, -0.01019978616386652, 0.00549948588013649, -0.021400269120931625, -0.02467360906302929, 0.009628383442759514, -0.0038118769880384207, -0.00026720837922766805, 0.01753394864499569, 0.004939038772135973, 0.013109718449413776, 0.014321277849376202, -0.009506838396191597, -0.009242286905646324, -0.013810068368911743, -0.0023309062235057354, -0.021143797785043716, 0.0003693578764796257, 0.007146262563765049, -0.002272261306643486, 0.0021483420860022306, 0.017616283148527145, 0.07195714116096497, 0.01126682385802269, 0.005322275683283806, -0.003239293582737446, -0.006054713390767574, 0.0004924916429445148, -0.04137478768825531, -0.00881914421916008, 0.004015520215034485, -0.01027304120361805, -0.009566234424710274, -0.009113332256674767, 0.043678168207407, 0.013125104829668999, 0.013993918895721436, -0.026766030117869377, 0.018064338713884354, 0.01415686309337616, -0.012674539349973202, -0.004881001077592373, 0.0020981072448194027, 0.03157416358590126, -0.005677448585629463, -0.025392483919858932, 0.005651033017784357, 0.007809173781424761, -0.023417223244905472, 0.028096821159124374, -0.01194294448941946, 0.006043560802936554, -0.017832985147833824, -0.012358556501567364, 0.005856135860085487, 0.001193070551380515, 0.02667517587542534, 0.020919324830174446, -0.003912881948053837, 0.008366204798221588, -0.013541280291974545, 0.009545674547553062, 0.011252360418438911, 0.011956759728491306, 0.004507953766733408, -0.0019485584925860167, 0.04586915299296379, 0.020570341497659683, 0.017919760197401047, -0.011058499105274677, 0.019847286865115166, 0.020274315029382706, 0.01730307564139366, 0.008795621804893017, 0.013699948787689209, -0.014018064364790916, 0.010191626846790314, 0.01691722311079502, 0.02470402419567108, 0.014723248779773712, -0.027623869478702545, -0.027628647163510323, 0.013009482994675636, -0.01403096690773964, -0.011494964361190796, -0.02050670050084591, 0.008046514354646206, -0.016459878534078598, 0.006060367915779352, -0.014145683497190475, -0.00722382590174675, 0.019537359476089478, 0.010124368593096733, 0.011188768781721592, 0.012194514274597168, 0.003222979139536619, -0.000972334761172533, -0.004545848350971937, 0.015347978100180626, -0.009436446242034435, 0.01013990305364132, 0.013968588784337044, -0.0013469423865899444, 0.014005191624164581, 0.002367454580962658, -0.005206555128097534, 0.012387938797473907, 0.02191472239792347, -0.024860264733433723, -0.010298419743776321, -0.006819379515945911, 0.009263885207474232, 0.0172678604722023, 0.004041620064526796, 0.010488193482160568, 0.01990426331758499, 0.00886079017072916, 0.033874258399009705, -0.0019577420316636562, 0.006803285796195269, 0.00137354526668787, 0.005266644526273012, 0.012813890352845192, 0.0010749250650405884, -0.004164825193583965, -0.0007572025060653687, -0.020880423486232758, 0.005727996118366718, -0.004066105931997299, 0.008974922820925713, -0.0025046654045581818, -0.010733827017247677, 0.01675567775964737, -0.0228708665817976, -0.003381401766091585, 0.0010009938850998878, -0.01506847608834505, 0.005079834721982479, -0.028487637639045715, 0.018816545605659485, -0.01167209167033434, -0.015062893740832806, -0.00718700559809804, 0.005380278453230858, -0.01112937368452549, 0.033128708600997925, 0.009063081815838814, -0.027306800708174706, -0.006635594181716442, 0.00666981702670455, -0.011534023098647594, -0.027808990329504013, 0.013448379933834076, 0.003061365569010377, -0.0053110867738723755, -0.0009200284257531166, 0.00538228265941143, -0.009708617813885212, 0.020956899970769882, 0.007456834893673658, 0.001825239509344101, -0.006381073966622353, 0.039686352014541626, -0.014785461127758026, -0.003243621438741684, -0.011291570961475372, 0.008012698963284492, -0.015397881157696247, -0.0177946537733078, -0.009163834154605865, 0.0034007406793534756, 0.003010009415447712, -0.00700709642842412, 0.0054196882992982864, 0.0017951508052647114, -0.009689568541944027, -0.021957196295261383, 0.022235646843910217, 0.010446780361235142, 0.04699920862913132, -0.013505477458238602, -0.008035420440137386, 0.011584978550672531, 0.02014591172337532, 0.01509010884910822, 0.009395611472427845, 0.014656651765108109, 0.02793409861624241, -0.033288002014160156, -0.015262622386217117, 0.0017630853690207005, 0.010740885511040688, 0.07075563073158264, 0.006392815615981817, 0.011705167591571808, 0.029300175607204437, -0.020211651921272278, -0.00903989840298891, -0.01765316352248192, -0.014787258580327034, -0.002487849909812212, 0.006179981864988804, 0.002395902294665575, -0.026997489854693413, 0.0002989377826452255, -0.011992108076810837, -0.0048553613014519215, 0.009573528543114662, -0.004543027840554714, 0.017402347177267075, -0.020840737968683243, -0.023107565939426422, -0.0005698315799236298, -0.028046194463968277, 0.010830562561750412, 0.0046323188580572605, -0.00703894067555666, 0.029022254049777985, 0.024557944387197495, -0.012134898453950882, -0.005163874011486769, 0.0010851232800632715, -0.008434361778199673, 0.002621210180222988 ]
[ 0.1420377939939499, -0.03398629277944565, -0.03674197942018509, -0.05039522051811218, 0.19604170322418213, 0.4547552466392517, 0.0627245083451271, 0.31150177121162415, -0.45678237080574036, -0.17235907912254333, -0.11637456715106964, 0.18350306153297424, -0.25368964672088623, -0.24449852108955383, -0.03612025827169418, 0.5376062989234924, 0.5736321210861206, 0.13734853267669678, -0.6357316374778748, -0.36090287566185, 0.011510360054671764, -0.4883072078227997, 0.6704421639442444, -0.1179279014468193, 0.04861966893076897, -0.24679602682590485, 0.3464224338531494, 0.2546420693397522, 0.1235649362206459, -0.20139968395233154, -0.24808089435100555, 0.5648605227470398, 0.12796813249588013, -0.3742019534111023, -0.25224047899246216, 0.42615389823913574, -0.4520299732685089, -0.5739099979400635, -0.16322052478790283, -0.05381364747881889, -0.0034548435360193253, -0.37318775057792664, -0.39862343668937683, 0.6259322762489319, -0.11856771260499954, 0.4993259012699127, -1.413977026939392, 0.4385969936847687, -0.06896264106035233, 0.36868759989738464, 0.14513695240020752, 0.15425711870193481, -0.0732874721288681, 0.18128637969493866, 0.5457025766372681, -0.07722222059965134, -0.7374106645584106, -0.5890445113182068, 0.14633919298648834, -0.41723233461380005, 0.08136830478906631, -0.06684955954551697, -0.1916843205690384, -0.025549007579684258, -0.23957528173923492, 0.5153892040252686, 0.06891593337059021, 0.0890989899635315, -0.6780370473861694, -0.1318797469139099, 0.46386101841926575, -0.34856265783309937, -0.3823210895061493, 0.5382449626922607, -0.07427571713924408, -0.13215602934360504, 0.03227480128407478, -0.43523865938186646, 0.32886379957199097, -0.18767958879470825, 0.23557525873184204, 0.19565685093402863, 0.8766288161277771, 0.6316829323768616, 0.09519021213054657, 0.2384224832057953, -0.10548947751522064, 0.8473908305168152, -0.2996538281440735, -0.3428565263748169, 0.14627693593502045, -0.008231500163674355, 0.3209070563316345, 0.3580305576324463, 0.20086157321929932, 0.7703444957733154, 0.5602156519889832, 0.059988848865032196, -0.2269975244998932, -0.24970875680446625, -0.051908474415540695, 0.7435238361358643, -0.17222024500370026, -0.31343260407447815, 0.006204416509717703, -0.33898165822029114, -0.01177896372973919, -0.17969706654548645, -0.2542552053928375, -0.21361905336380005, -0.8627228736877441, 0.07859744131565094, 0.15473546087741852, -0.49776068329811096, -0.12761543691158295, 0.08028468489646912, 0.18342672288417816, -0.3408317267894745, -0.08798345923423767, -0.12345512211322784, 0.28451403975486755, 0.7973752617835999, -0.30564257502555847, 0.25285208225250244, -0.5378304123878479, -0.06353055685758591, -0.12923376262187958, 0.28913024067878723, -0.04903301224112511, 0.7642250061035156, -0.17656667530536652, 0.22293728590011597, -0.4204320013523102, -0.10912882536649704, 0.5395871996879578, -0.07919113337993622, -0.07815923541784286, 0.13188117742538452, 0.7451505661010742, 0.2528607249259949, -0.7321661114692688, -0.503046989440918, -0.5119777917861938, -0.19847309589385986, 0.04873702675104141, -0.4132939875125885, 0.055154815316200256, 0.386266827583313, 0.23149698972702026, -0.2509319484233856, -0.32292109727859497, -0.2919655740261078, -0.5897505283355713, -0.2930501103401184, -0.17538033425807953, 0.38919004797935486, 0.3001560568809509, -0.7204725742340088, 0.13530489802360535, 0.23012034595012665, 0.06259876489639282, -0.5384576320648193, -0.33822739124298096, -0.18723514676094055, 0.2833520472049713, -0.11043528467416763, 0.6111147403717041, 0.12413712590932846, 0.1926259547472, 0.04233812540769577, -0.6035269498825073, -0.5375107526779175, 0.38703376054763794, -0.49165239930152893, 0.19156436622142792, 0.1327563375234604, 0.3788941204547882, 0.3319036364555359, 0.2357468605041504, 0.20874235033988953, -0.9595778584480286, 0.26513662934303284, 0.18080544471740723, -0.2404317557811737, 0.31142163276672363, -0.2963985204696655, 0.5347195863723755, -0.2587568461894989, -0.0318586602807045, 0.0467991940677166, 0.40484246611595154, -0.6129235029220581, 1.01395845413208, -0.16548794507980347, 1.2052122354507446, -0.4053700268268585, -0.5156117081642151, 0.17602252960205078, 0.5524114370346069, 0.04464617371559143, -0.11876583844423294, -0.15206901729106903, 0.4743824601173401, -0.12144060432910919, -0.3595607578754425, 0.0007599120726808906, 0.05674855038523674, -0.3027138113975525, 0.23624511063098907, -0.037637196481227875, 0.5463127493858337, -0.953441858291626, -0.02399178221821785, 0.012749181129038334, 0.1669611781835556, -0.6091724634170532, -0.13210377097129822, -0.16900557279586792, -0.6433380842208862, -0.3116503953933716, 0.2957913875579834, -0.6725137233734131, 0.30723294615745544, 0.5788179039955139, -0.07879247516393661, 0.763403058052063, 0.4626208245754242, 0.11100742220878601, 1.0144141912460327, -0.498235285282135, 0.3133631944656372, 0.27580052614212036, -0.37031352519989014, -0.5618692636489868, 0.17142248153686523, 0.23399507999420166, 0.06369265913963318, -0.4875146448612213, 0.22587737441062927, 0.3148975968360901, -0.33948543667793274, 0.6195138096809387, -0.8492555618286133, -0.14362475275993347, 0.28197094798088074, -0.655632495880127, -0.40810784697532654, 0.293817400932312, -0.8541150689125061, -0.22911337018013, -0.261671245098114, 0.061856694519519806, -0.36790192127227783, -0.6105782389640808, 0.0386660173535347, 0.2459462732076645, 0.28494158387184143, -0.25531765818595886, -0.11405754834413528, -0.7600347399711609, -0.37196627259254456, 0.15719546377658844, -0.03298967331647873, 0.2460838109254837, 0.10346409678459167, -0.5324463844299316, -0.6686984896659851, -0.023365981876850128, 0.6255897283554077, 0.4927609860897064, 0.8520685434341431, 0.1925346702337265, -0.5166725516319275, -0.15392553806304932, -0.4312175214290619, -0.14936651289463043, -0.6233330965042114, 0.5983310341835022, -0.6802597045898438, -0.26331502199172974, 0.12060822546482086, 0.721083402633667, 0.6966214776039124, -0.021594855934381485, -0.3834329843521118, 0.4517369270324707, -0.14788755774497986, -0.376325398683548, -0.2305707037448883, -0.4342273473739624, -0.2018958032131195, 0.22873236238956451, 0.04935272037982941, 0.22329293191432953, 0.34322190284729004, -0.18768368661403656, 0.2065146118402481, 0.20688575506210327, 0.3141459822654724, -0.05706869065761566, -0.9207593202590942, -0.029942777007818222, -0.5070227384567261, -0.10628564655780792, -0.15782523155212402, 0.4236416518688202, -0.4966052770614624, 0.20995433628559113, -5.7711944580078125, -0.17345713078975677, -0.4341334104537964, -0.17977632582187653, 0.5189889073371887, 0.22775259613990784, 0.6034793257713318, 0.06986909359693527, -0.007186391390860081, 0.2060575634241104, 0.26088643074035645, 0.36101606488227844, -0.1038491353392601, 0.16962438821792603, -0.46099504828453064, -0.31497612595558167, -0.2438136637210846, 0.05721420422196388, 0.6416419744491577, -0.4500383138656616, -0.03523411229252815, -0.7016597390174866, -0.047001250088214874, 0.7464142441749573, 0.00001675434577919077, 0.29265710711479187, -0.6758003234863281, 0.35023054480552673, 0.046795666217803955, -0.44479864835739136, -0.06937610357999802, -0.4945247173309326, -0.024151349440217018, -0.015735585242509842, 0.3554423153400421, 0.06801513582468033, 0.3770970106124878, -0.1016266793012619, -0.42565324902534485, -0.562181830406189, 0.2276405543088913, -0.4030188024044037, -0.12000174075365067, -0.08520682156085968, 0.21344774961471558, 0.09824755042791367, 0.32322263717651367, 0.3484079837799072, -0.21011975407600403, 0.528887152671814, 0.5536701679229736, -0.08548060804605484, 0.08878450840711594, 0.6043851971626282, 0.8865254521369934, 0.19790010154247284, 0.17119112610816956, -0.17925138771533966, 0.04863224923610687, 0.07233867794275284, -0.2655171751976013, -0.027168426662683487, -0.22767603397369385, -0.7613568902015686, -0.400934100151062, 0.4391041398048401, -0.16533824801445007, 0.2850409746170044, 0.9059455394744873, -0.6421241760253906, -0.389238178730011, 0.6491477489471436, 0.21491265296936035, -0.7081301212310791, 0.43093737959861755, -0.032120972871780396, 0.6335987448692322, 0.4658728539943695, -0.38928836584091187, -0.23120170831680298, -0.35097911953926086, -0.14067547023296356, 0.05589951574802399, -0.18736180663108826, 0.21750342845916748, -0.3683415353298187, -0.24101699888706207, 0.4612424671649933, 0.42611706256866455, 0.5413127541542053, 0.7424902319908142, 0.11975859105587006, 0.23781631886959076, 0.5879308581352234, 0.3686993420124054, 0.46456849575042725, 0.30243703722953796, 0.5172284245491028, 0.5028111338615417, 0.2995753586292267, 0.6768949627876282, -0.11493249237537384, -0.3681301474571228, -0.6329305768013, -0.37180593609809875, -0.2209792137145996, -0.6339403390884399, -0.07495690882205963, 0.7856363654136658, -0.6530275344848633, 0.6040664911270142, 0.0807274878025055, 0.06265819817781448, -0.6586605310440063, 0.6100794076919556, -0.11473796516656876, -0.21021676063537598, 0.428233802318573, 0.9835464358329773, -0.6415778398513794, 0.018880570307374, 0.3661360740661621, -0.9311540722846985, 0.08006081730127335, 0.6725786924362183, 0.33777543902397156, 0.0046948883682489395, 0.944692850112915, -0.6663427948951721, -0.17426733672618866, 0.2486456334590912, 0.7153816223144531, -0.26212072372436523, 0.5921753644943237, -0.06943581253290176, -0.8847318887710571, -0.4310537576675415, 0.26929789781570435, 0.3707543611526489, -0.15912330150604248, 0.4914505183696747, -0.2707657814025879, 0.08618409931659698, -0.1281803995370865, 0.08988255262374878, -0.21107657253742218, -0.2509775459766388, -0.02803718112409115, -0.220002219080925, -0.13386327028274536, 0.6700502634048462, -0.6132357716560364, 0.3728882372379303, 0.0916648879647255, 0.1824539750814438, 0.2746071517467499, -0.2307431995868683, 0.1200285404920578, -0.22942028939723969, -0.7753940224647522, 0.15302707254886627, 0.19330564141273499, -0.45754221081733704, -0.5042606592178345, -0.4545343220233917, -0.23434816300868988, 0.019748711958527565, -1.070834994316101, -0.26911988854408264, 0.08715465664863586, -0.468858927488327, -0.33718055486679077, -0.07646699994802475, 0.023069823160767555, 0.4049212336540222, -0.40390896797180176, -0.47761645913124084, -0.11979173123836517, 0.07229040563106537, -0.34936413168907166, 0.0944281592965126, 0.05767007917165756, -0.06841892004013062, 0.33422502875328064, 0.9077562689781189, -0.09015881270170212, 0.050848472863435745, -0.25380805134773254, -0.48445776104927063, -0.4695367217063904, 0.16205762326717377, 0.4148721396923065, 0.08629712462425232, -0.01744004525244236, 0.13927650451660156, 0.4594747722148895, 0.3642081320285797, 0.2530660331249237, -0.04710645601153374, -0.5335678458213806, 0.18707111477851868, 0.19821970164775848, -0.07518863677978516, 0.19043608009815216, 0.7824881076812744, -0.2307039201259613, -0.02742690220475197, 0.16574643552303314, -0.47366538643836975, 0.06052708998322487, 0.024248123168945312, -0.5643179416656494, 0.13078202307224274, 0.4071444571018219, -0.4335980713367462, 0.08785532414913177, 0.24833086133003235, -0.5917656421661377, -0.34529784321784973, 0.4965372085571289, 0.22348831593990326, 0.10584397614002228, 0.21167537569999695, 0.043488916009664536, -0.7575472593307495, 0.1229640319943428, 0.39214926958084106, -0.5298063158988953, 0.13584381341934204, -0.02739279344677925, -0.07534828782081604, -0.30980661511421204, -0.35993722081184387, -0.20201505720615387, 0.3400363624095917, -0.39740145206451416, 0.27646008133888245, 0.30714231729507446, -0.2775266766548157, 0.10625298321247101, 0.5625414252281189, 0.7660455703735352, -0.2881242036819458, -0.10922018438577652, -0.20205017924308777, 0.21516652405261993, 0.018082214519381523, -0.9337759017944336, -0.3473398983478546, 0.28630220890045166, 0.7553454637527466, -0.17588068544864655, -0.14511935412883759, 0.39094340801239014, 0.5727053284645081, -0.323074072599411, -0.42869123816490173, -0.6993389129638672, -0.1083509773015976, 0.1999233216047287, -0.11369487643241882, -0.29724809527397156, 0.23805522918701172, 0.09146293252706528, -0.06865210831165314, 0.04151427745819092, -0.16969551146030426, -0.7064794898033142, 0.6688944101333618, -0.32126957178115845, 0.0654885545372963, 0.04082559049129486, 0.6337131261825562, 0.42454859614372253, -0.2778978943824768, 0.19998954236507416, 0.30042627453804016, -0.156816303730011, 0.027558233588933945, 0.5417343974113464, 0.10960623621940613, -0.1727723628282547, 0.05152858793735504, -0.6073077321052551, 0.3435923755168915, -0.7471297979354858, 0.485319048166275, -0.41210663318634033, 0.046901848167181015, 0.2203204333782196, -0.21615242958068848, 0.1941481977701187, -0.008445427753031254, -0.5857788324356079, 0.1595620959997177, 0.33587193489074707, 0.527587354183197, 0.3578794300556183, -0.2503466010093689, 0.027697889134287834, -0.6062971353530884, 0.45644816756248474, 0.4004995822906494, -0.6390033960342407, -0.31102266907691956, 0.1544840782880783, -0.15842463076114655, -0.38316604495048523, -0.5165327787399292, -0.09730248898267746, 0.09357155114412308, -0.2546240985393524, 0.006735636852681637, 1.0760529041290283, -0.20647728443145752, -0.15816248953342438, -0.1375400722026825, 0.0038146900478750467, 0.22043590247631073, 0.41125068068504333, -0.0010707732290029526, 1.2340822219848633, 0.22136290371418, -0.33802297711372375, -0.039579764008522034, 0.09956604242324829, 0.2926032245159149, 0.4876540005207062, 0.25700297951698303, 0.7142926454544067, 0.6467183232307434, -0.030525749549269676, -0.0315832756459713, 1.0803782939910889, 0.5071706771850586, -0.03730224817991257, 0.024092748761177063, -0.6949047446250916, -0.09243136644363403, -0.03877818584442139, 0.3978678584098816, 0.28019067645072937, 0.2947668135166168, -0.27188509702682495, 0.29404959082603455, 0.3562784194946289, -0.05630101263523102, -0.22447645664215088, 0.16701489686965942, -0.022154567763209343, 0.43511438369750977, -0.6094410419464111, -0.13202403485774994, -0.3096400499343872, -0.5988066792488098, 0.042013078927993774, -0.03824878856539726, -0.28782525658607483, -0.2527925670146942, 0.440757155418396, -0.3360711932182312, 0.027229029685258865, -0.3021606206893921, 0.4240622818470001, -0.02708303928375244, -0.36844226717948914, 0.4631241261959076, -0.019651414826512337, 0.6062853336334229, 0.08263213187456131, 0.1408967226743698, 0.16981199383735657, -0.2259562760591507, 0.08207958191633224, 0.5134786367416382, -0.46199217438697815, 0.2777022421360016, -0.0030374890193343163, -0.028282858431339264, 0.1903637945652008, -0.3888964354991913, 0.16268868744373322, -0.2252209335565567, -0.6063513159751892, 0.1758326143026352, -0.5162851810455322, -0.07326716184616089, 0.08910384774208069, 0.24018047749996185, 0.19383448362350464, -0.10930788516998291, -0.3597415089607239, 0.32084816694259644, -0.1893904209136963, 0.21152622997760773, -0.5910906195640564, -0.3024812638759613, -0.3909185230731964, 0.14191292226314545, 0.1259050965309143, 0.028509026393294334, 0.4338971674442291, 0.07397228479385376, 0.02044539898633957, -0.849344789981842, 0.5314280986785889, -0.2686188817024231, -0.179660364985466, -0.1205364465713501, 0.07678202539682388, 0.810339629650116, 0.8041532039642334, -0.22803398966789246, 0.6728507280349731, 0.35680124163627625, -0.09133937954902649, 0.42073407769203186, -0.5367245674133301, -0.5488011240959167, -0.42289480566978455, 0.084195576608181, -0.4397936463356018, 0.46663856506347656, -0.030294857919216156, -0.26625651121139526, 0.07796129584312439, 0.6758314967155457, -0.18840643763542175, -0.1742739975452423, 0.38032886385917664, -0.6482045650482178, 0.5236458778381348, -0.8005341291427612, -0.20951129496097565, -0.3910674750804901, -0.3614652752876282, -0.27366068959236145, -0.17407941818237305, -0.3672955334186554, -0.46303364634513855, 0.4951443374156952, -0.2960108518600464, -0.22567838430404663, -0.07041939347982407, 0.25114965438842773, -0.049983296543359756, -0.22500035166740417, -0.5515173673629761, -0.45888087153434753, -0.00016961769142653793, 0.10996946692466736, -0.5421107411384583, 0.25523263216018677, -0.017449956387281418, 0.065610870718956, -0.09750598669052124, -0.06000477820634842, -0.1825208067893982, -0.19172562658786774, 0.006605625618249178 ]
The aims of this randomised controlled trial were to determine if a high-intensity functional exercise program improves balance, gait ability, and lower-limb strength in older persons dependent in activities of daily living and if an intake of protein-enriched energy supplement immediately after the exercises increases the effects of the training. One hundred and ninety-one older persons dependent in activities of daily living, living in residential care facilities, and with a Mini-Mental State Examination (MMSE) score of ? 10 participated. They were randomised to a high-intensity functional exercise program or a control activity, which included 29 sessions over 3 months, as well as to protein-enriched energy supplement or placebo. Berg Balance Scale, self-paced and maximum gait speed, and one-repetition maximum in lower-limb strength were followed-up at three and six months and analysed by 2 x 2 factorial ANCOVA, using the intention-to-treat principle. At three months, the exercise group had improved significantly in self-paced gait speed compared with the control group (mean difference 0.04 m/s, p = 0.02). At six months, there were significant improvements favouring the exercise group for Berg Balance Scale (1.9 points, p = 0.05), self-paced gait speed (0.05 m/s, p = 0.009), and lower-limb strength (10.8 kg, p = 0.03). No interaction effects were seen between the exercise and nutrition interventions. In conclusion, a high-intensity functional exercise program has positive long-term effects in balance, gait ability, and lower-limb strength for older persons dependent in activities of daily living. An intake of protein-enriched energy supplement immediately after the exercises does not appear to increase the effects of the training.
[ 0.010197054594755173, 0.008935820311307907, 0.002734664361923933, 0.015831511467695236, -0.008273178711533546, -0.01175670512020588, 0.008714133873581886, -0.012827337719500065, -0.012512430548667908, -0.013607906177639961, -0.013866143301129341, 0.022969938814640045, -0.005808582529425621, 0.004547400400042534, 0.025280719622969627, -0.026365716010332108, -0.018750503659248352, 0.015596546232700348, 0.005673984996974468, -0.0003982554189860821, -0.030482251197099686, -0.0005480898544192314, 0.01051776111125946, -0.01385524496436119, -0.007128756493330002, 0.03383834287524223, 0.0051444899290800095, -0.00028818845748901367, -0.00332830217666924, -0.035740695893764496, 0.002495095133781433, 0.006494954228401184, 0.015073017217218876, 0.004558431915938854, 0.010330542922019958, -0.0034165573306381702, 0.0008020963286980987, 0.013765627518296242, 0.020488964393734932, -0.004735223483294249, 0.013633155263960361, -0.005540220066905022, 0.0009529092931188643, -0.021802620962262154, -0.011638743802905083, 0.006944000720977783, -0.0035729813389480114, 0.014098593965172768, -0.005692513659596443, 0.011749664321541786, -0.009498471394181252, -0.0021611214615404606, -0.012012066319584846, -0.03179217129945755, -0.006111619062721729, 0.004363014362752438, 0.019874967634677887, -0.003110859077423811, -0.0073355454951524734, -0.03655609115958214, -0.02187611535191536, -0.007664498873054981, 0.00029952963814139366, 0.00354420836083591, -0.034871261566877365, -0.06684349477291107, -0.018159596249461174, 0.011510191485285759, 0.018357377499341965, 0.02275906875729561, 0.005754426121711731, 0.00826859287917614, -0.005798753350973129, 0.02565566822886467, 0.016578536480665207, -0.021632233634591103, -0.0041214218363165855, -0.009320990182459354, 0.0295867957174778, 0.012232692912220955, -0.014093267731368542, 0.007290040608495474, 0.006959288381040096, 0.02091149613261223, 0.007848866283893585, 0.002140448894351721, -0.014677099883556366, -0.03538895398378372, 0.006932907737791538, -0.003723575733602047, -0.0011427807621657848, 0.0004299029242247343, 0.04169493913650513, 0.006094105541706085, 0.008935017511248589, 0.011828603222966194, -0.00229802168905735, -0.02269584871828556, -0.015683863312005997, -0.008555072359740734, -0.0015385551378130913, 0.0049799056723713875, 0.02334701083600521, -0.008240407332777977, -0.0013991235755383968, 0.00950615294277668, 0.0021064914762973785, 0.030006369575858116, 0.01788550615310669, 0.00460868189111352, 0.013481710106134415, -0.014104098081588745, -0.00555602740496397, 0.041843168437480927, 0.009049525484442711, 0.017150722444057465, 0.005356081761419773, 0.00971195288002491, 0.009884105995297432, -0.01797504909336567, 0.006787885911762714, 0.017901241779327393, -0.00035783316707238555, -0.0080198859795928, 0.00206987326964736, 0.009783035144209862, 0.04808471351861954, 0.008842898532748222, -0.016477808356285095, 0.017352482303977013, -0.006781138479709625, -0.0006080722669139504, -0.014123434200882912, 0.0015395712107419968, -0.0030330996960401535, -0.013710209168493748, -0.011101966723799706, -0.02176046557724476, -0.0016511514550074935, -0.017492370679974556, -0.009059220552444458, 0.00546787166967988, -0.0008173813112080097, 0.011520168744027615, 0.01586463302373886, -0.012550334446132183, 0.020942024886608124, 0.005785444285720587, -0.0053831301629543304, -0.01082042045891285, 0.02891533076763153, -0.02417062222957611, 0.007609095424413681, -0.03816376253962517, 0.0032843798398971558, 0.021085096523165703, -0.005204363260418177, -0.012933708727359772, -0.020221468061208725, 0.01748654805123806, -0.01112656481564045, -0.023739043623209, 0.02920648828148842, 0.008546377532184124, 0.016908487305045128, 0.027333617210388184, -0.0012814207002520561, -0.01834115758538246, 0.010285664349794388, 0.004837585147470236, -0.0047814929857850075, -0.002328290371224284, -0.01981157436966896, 0.0036440182011574507, 0.007568710949271917, 0.0027541203889995813, -0.023536870256066322, 0.012503965757787228, -0.005044905468821526, 0.06626632809638977, -0.0027687987312674522, 0.010389117524027824, -0.019086547195911407, 0.028217295184731483, -0.02106297016143799, -0.014962734654545784, 0.015509964898228645, -0.01006147637963295, 0.004082175903022289, 0.016651518642902374, 0.00853947177529335, 0.004917020909488201, 0.012787619605660439, -0.000007942784577608109, 0.006131468806415796, 0.004197178408503532, 0.03718932718038559, 0.006820071954280138, -0.019825244322419167, -0.030107833445072174, 0.003865521401166916, -0.0028569591231644154, 0.036837026476860046, -0.002063420135527849, 0.008056897670030594, 0.007197066675871611, 0.02184288576245308, -0.004603296052664518, 0.0009791499469429255, 0.0026207007467746735, 0.01029752567410469, 0.008791902102530003, -0.007036974653601646, -0.018837524577975273, 0.034209541976451874, -0.0006240599323064089, 0.006795293651521206, 0.021583886817097664, 0.004094766918569803, -0.012164999730885029, 0.007856831885874271, -0.01362715382128954, -0.0014868136495351791, -0.02460596337914467, 0.016425486654043198, 0.02422374114394188, 0.010612855665385723, 0.010870484635233879, -0.0001193685457110405, 0.004101059399545193, 0.0021583770867437124, -0.031810909509658813, -0.007963360287249088, -0.0021779476664960384, -0.002908948576077819, 0.02285427413880825, 0.012377405539155006, -0.027679435908794403, 0.008492609485983849, -0.015429798513650894, 0.008743845857679844, 0.00837798323482275, 0.01952505111694336, -0.023601988330483437, 0.013498185202479362, -0.00728704035282135, 0.0017086463049054146, -0.01747477985918522, 0.0016504913801327348, -0.0013385608326643705, 0.005563146434724331, 0.0037916009314358234, -0.03293224051594734, -0.030067721381783485, 0.012616772204637527, -0.002572527388110757, -0.034219443798065186, 0.008863831870257854, 0.025050088763237, 0.006628554314374924, 0.014339802786707878, 0.009091074578464031, -0.017870008945465088, 0.021778326481580734, 0.0020183580927550793, -0.004668394103646278, -0.0066468603909015656, 0.02119011990725994, 0.005991277284920216, -0.003949336241930723, 0.005381262395530939, -0.00919304694980383, -0.008033755235373974, -0.08126881718635559, -0.007652942091226578, 0.00291885226033628, -0.020429210737347603, 0.0064002107828855515, 0.0037408554926514626, 0.01654161885380745, 0.011453907936811447, -0.01735307276248932, 0.0165423471480608, -0.029635228216648102, -0.004123268648982048, -0.004901343025267124, 0.015769893303513527, 0.002978845266625285, -0.007575000170618296, 0.007051668595522642, 0.0017705054488033056, -0.014908657409250736, -0.01321472879499197, -0.005922052077949047, -0.008956924080848694, 0.010168253444135189, -0.0025171274319291115, -0.010830187238752842, -0.005697892978787422, 0.024387694895267487, -0.012774270959198475, -0.010622747242450714, 0.025134233757853508, -0.01919521763920784, -0.009614396840333939, -0.007965093478560448, 0.0017198589630424976, 0.0014603713061660528, 0.03474452719092369, -0.014039930887520313, 0.0023890743032097816, 0.004402730613946915, 0.020170722156763077, 0.013544723391532898, -0.0008636870188638568, 0.0012815827503800392, 0.0007006779778748751, 0.002842554822564125, -0.0043524932116270065, 0.036435116082429886, 0.013241233304142952, 0.014871318824589252, 0.0034108562394976616, 0.005308255553245544, -0.016452353447675705, 0.025577381253242493, 0.013586044311523438, -0.024208281189203262, 0.0013533718883991241, -0.0008033466292545199, 0.018355751410126686, -0.007870681583881378, -0.005330112297087908, -0.04072780907154083, -0.021977199241518974, 0.014358146116137505, 0.0233108252286911, 0.011404896154999733, 0.009943186305463314, -0.0025719215627759695, 0.007980268448591232, -0.016109950840473175, 0.028909657150506973, -0.007134725805372, -0.019491495564579964, -0.00015071011148393154, -0.008380496874451637, 0.01214512437582016, -0.010688775219023228, -0.023367155343294144, 0.004256267566233873, 0.042058564722537994, 0.009736830368638039, 0.002288451651111245, 0.0017303586937487125, -0.020005743950605392, -0.005263036582618952, -0.01313545648008585, 0.005255068652331829, 0.015795571729540825, 0.01594420336186886, 0.016255592927336693, -0.009854070842266083, 0.011365847662091255, 0.03705296292901039, 0.02371562086045742, 0.005418275482952595, -0.023523136973381042, -0.00349347828887403, 0.00395391508936882, 0.0041102273389697075, 0.004971799440681934, 0.009355735033750534, -0.014392821118235588, -0.00036020809784531593, 0.014459093101322651, -0.017171863466501236, -0.0012846747413277626, 0.012246867641806602, -0.018502335995435715, 0.002234169514849782, 0.008598918095231056, -0.013322290033102036, -0.022898279130458832, 0.00021093105897307396, -0.013831080868840218, 0.017470981925725937, 0.006531687919050455, -0.018707677721977234, -0.013509774580597878, 0.003474110271781683, 0.07257577776908875, 0.006704839877784252, 0.02116524614393711, -0.013920255936682224, 0.013312631286680698, 0.001640054862946272, 0.006277305074036121, 0.007288002409040928, -0.0005059989052824676, -0.018900061026215553, 0.012113029137253761, 0.030421661213040352, -0.016552120447158813, -0.01377719733864069, -0.010304602794349194, 0.010960012674331665, -0.004714086651802063, -0.0207986980676651, -0.0020001542288810015, -0.004799123387783766, 0.0020224866457283497, -0.028366107493638992, -0.018093327060341835, -0.004078839439898729, 0.018183903768658638, -0.0048861452378332615, -0.024915365502238274, -0.014879478141665459, 0.008797047659754753, 0.006411953363567591, 0.00608079181984067, 0.015069011598825455, -0.003775340737774968, -0.006248373072594404, 0.004080129787325859, 0.01214949507266283, 0.007850171998143196, -0.0016258684918284416, 0.01157352514564991, -0.011295407079160213, -0.04988369345664978, -0.012738922610878944, 0.008793221786618233, 0.011020185425877571, -0.025395013391971588, 0.011217295192182064, -0.007345631718635559, -0.005708674900233746, -0.0008880975656211376, 0.008119218051433563, -0.005397849716246128, 0.021543823182582855, 0.008000103756785393, -0.005553471855819225, 0.0025566478725522757, 0.019866548478603363, 0.0018886472098529339, -0.00719125010073185, 0.021136539056897163, 0.010769525542855263, -0.023248836398124695, -0.02429524064064026, 0.0049171228893101215, -0.036212947219610214, -0.014511870220303535, -0.018804047256708145, 0.04802684485912323, -0.0006673531606793404, 0.01563090644776821, 0.018359709531068802, -0.00448696780949831, 0.016225554049015045, -0.007561042904853821, -0.004297496285289526, 0.00657351128757, -0.037800051271915436, -0.03501679748296738, -0.016876395791769028, -0.01244549360126257, 0.02203981578350067, -0.018448252230882645, 0.023982059210538864, 0.007644230034202337, 0.0009570043184794486, 0.031497202813625336, 0.01926441676914692, -0.03020315244793892, -0.07507769763469696, -0.0033818669617176056, 0.006015929393470287, -0.014436201192438602, -0.032737258821725845, 0.019070686772465706, -0.017556723207235336, 0.01462117861956358, -0.029011694714426994, -0.008928230963647366, 0.0067391181364655495, 0.015161087736487389, 0.022992314770817757, -0.021566443145275116, 0.015801645815372467, 0.011010824702680111, -0.009381256066262722, -0.001882876385934651, -0.014613373205065727, -0.027118191123008728, 0.00030713528394699097, 0.02176223136484623, 0.0021644942462444305, 0.00845631305128336, 0.00039652432315051556, -0.08127312362194061, 0.014680172316730022, 0.005334322340786457, -0.0013444647192955017, -0.01840358041226864, -0.004997996147722006, 0.0013495194725692272, 0.0025743553414940834, -0.02545248344540596, -0.01191837340593338, 0.02317572757601738, -0.0013520364882424474, 0.016104068607091904, -0.014623327180743217, 0.012581095099449158, -0.00489005446434021, -0.000970164779573679, 0.003116210224106908, -0.009684056043624878, 0.0003306369762867689, -0.030066711828112602, 0.005680592730641365, -0.005923614837229252, 0.013035420328378677, -0.011161500588059425, -0.015413027256727219, 0.01578477770090103, 0.008725515566766262, 0.0010730319190770388, 0.004691921174526215, 0.022552482783794403, -0.0036262485664337873, -0.01959843561053276, -0.030664954334497452, -0.014485370367765427, -0.015938734635710716, -0.010748399421572685, -0.011611491441726685, 0.00488688051700592, -0.0076904501765966415, -0.006457967218011618, 0.020558180287480354, 0.031010910868644714, 0.004509662743657827, 0.01918746903538704, -0.016964588314294815, 0.006957699544727802, -0.009833293035626411, 0.011397814378142357, -0.012909789569675922, 0.014936842024326324, 0.010230567306280136, 0.022297179326415062, 0.0010289372876286507, 0.004218989983201027, -0.017065316438674927, -0.010503433644771576, 0.0173223614692688, 0.02319454215466976, -0.0024228650145232677, -0.006806332617998123, 0.0009476745035499334, -0.004735050722956657, 0.07112231105566025, -0.025318259373307228, 0.00845208391547203, 0.006333217024803162, 0.018738791346549988, 0.0016171042807400227, 0.0015927848871797323, -0.01750214956700802, 0.048939939588308334, -0.00758030079305172, 0.01804421842098236, -0.0011830853763967752, -0.009117279201745987, 0.009050658904016018, 0.01498818676918745, -0.019992239773273468, -0.008974152617156506, 0.008717391639947891, -0.052467674016952515, 0.030027776956558228, 0.008781135082244873, 0.014117507264018059, -0.005439397878944874, 0.013642793521285057, -0.011862291023135185, -0.010689474642276764, 0.004756703041493893, -0.004622003063559532, -0.011409821920096874, -0.009934226050972939, -0.0031360392458736897, -0.0012264784891158342, 0.006569662131369114, -0.008633093908429146, 0.0025558429770171642, -0.009717592038214207, 0.014335665851831436, 0.0001771487295627594, -0.022511914372444153, -0.006281110458076, 0.02398599684238434, -0.0021129294764250517, 0.011346850544214249, 0.002570013515651226, 0.013321716338396072, -0.015337267890572548, -0.008275900967419147, -0.0242534801363945, 0.0016600105445832014, 0.01177240815013647, 0.009320934303104877, -0.0047153583727777, 0.006338112987577915, -0.008449207991361618, 0.016999131068587303, 0.0029669178184121847, 0.016058897599577904, 0.016500093042850494, -0.008294443599879742, -0.024526474997401237, 0.002947638276964426, -0.005626888945698738, 0.02055082470178604, -0.012771032750606537, 0.02631303295493126, 0.022669196128845215, 0.005367663688957691, -0.004401586018502712, -0.0014722095802426338, 0.014971071854233742, -0.008114307187497616, 0.01655736193060875, 0.006728656589984894, 0.014506882056593895, 0.011359525844454765, 0.004858752246946096, 0.008566734381020069, -0.0014109116746112704, 0.017089571803808212, 0.015535261482000351, -0.008057503029704094, 0.0065731629729270935, -0.024262651801109314, 0.0028022443875670433, 0.012976046651601791, 0.009450173005461693, -0.0006938818842172623, 0.023730088025331497, -0.0026244940236210823, 0.004458303563296795, 0.026962362229824066, -0.007087899371981621, 0.0043639387004077435, 0.016031064093112946, 0.006780977360904217, 0.03410667926073074, 0.0028757196851074696, 0.005091551691293716, -0.0029394901357591152, 0.008589002303779125, -0.031494833528995514, -0.013645696453750134, -0.019009485840797424, 0.023058980703353882, 0.010598618537187576, 0.005066934507340193, 0.04638747125864029, 0.002413169015198946, 0.00792789924889803, 0.001446459675207734, -0.01812588796019554, 0.0058382172137498856, 0.03561266511678696, 0.027651213109493256, -0.00995217077434063, 0.030510108917951584, -0.011930009350180626, -0.017905931919813156, 0.0011727469973266125, -0.010659045539796352, 0.015608308836817741, 0.00258907163515687, -0.02183588221669197, -0.0033757220953702927, 0.012855655513703823, -0.018691860139369965, -0.013441208750009537, -0.02199377864599228, 0.045483097434043884, 0.013997044414281845, 0.004164182115346193, -0.020324785262346268, -0.012915830127894878, 0.014963747933506966, 0.004644560627639294, -0.02085641771554947, 0.008493626490235329, -0.00884353555738926, -0.018400656059384346, 0.009712260216474533, 0.035708166658878326, 0.01363198272883892, -0.0006232636515051126, -0.004267518408596516, 0.006711790803819895, -0.017795134335756302, 0.003459248226135969, 0.016893144696950912, 0.02214915305376053, 0.015208069235086441, -0.0117175979539752, 0.003733714809641242, -0.012701370753347874, -0.005583401303738356, -0.022706076502799988, 0.018229395151138306, 0.0039036585949361324, 0.010801494121551514, 0.008858212269842625, -0.014784928411245346, 0.017821840941905975, 0.008041102439165115, 0.0015215689782053232, -0.0038066464476287365, -0.01582883670926094, -0.002396988682448864, 0.017368147149682045, -0.005330556072294712, -0.014824045822024345, 0.02313295006752014, 0.009765660390257835, -0.011965325102210045, 0.007521426770836115, 0.017993371933698654, 0.010697524063289165, -0.00581024494022131, -0.0011307371314615011, -0.010934047400951385, 0.01229102909564972, 0.026494663208723068, -0.0014393068850040436, -0.01639563962817192, -0.005845905281603336, -0.014926549978554249, 0.021521801128983498, -0.01277027279138565, -0.009693488478660583, 0.006802461110055447, 0.009860856458544731, 0.010339327156543732, -0.012765026651322842, -0.004511786624789238, -0.012753226794302464, 0.015374201349914074, -0.008100586012005806, -0.000042986124753952026, 0.017388273030519485, 0.003539110068231821, -0.005148837808519602, 0.02002296783030033, 0.02211068384349346, -0.00672501977533102 ]
[ 0.18136970698833466, -0.1253332644701004, -0.08140342682600021, -0.008814271539449692, 0.13202832639217377, 0.6961082816123962, 0.6042289137840271, -0.7580900192260742, -0.1988944560289383, -0.10075781494379044, -0.22929556667804718, 0.5064367055892944, -0.14620044827461243, -0.5388506054878235, -0.047548796981573105, 0.694471001625061, 0.9022611975669861, 0.1635267585515976, -0.1173131987452507, -0.591311514377594, -0.2259904146194458, 0.0030103859025985003, 0.6378090381622314, -0.10152321308851242, -0.4566801190376282, 0.371246337890625, 0.8328437805175781, -0.15680620074272156, -0.09715361893177032, -0.3148249685764313, -0.056800395250320435, 0.7172690033912659, -0.2485944628715515, -0.3822627067565918, 0.24076320230960846, 0.44755783677101135, 0.06949251890182495, -0.3226351737976074, 0.0854337066411972, -0.7872171401977539, -0.20850761234760284, -0.07466509938240051, -0.46199917793273926, 0.7072893977165222, -0.20722603797912598, 0.02936803735792637, -1.2012653350830078, 0.10232001543045044, -0.5358354449272156, 0.03756892308592796, -0.17394377291202545, 0.3127656579017639, 0.8950938582420349, -0.05129420757293701, -0.07592251151800156, 0.42849764227867126, -0.42867743968963623, -0.16565857827663422, 0.3321167230606079, -0.15428051352500916, 0.7437536716461182, -0.19332990050315857, 0.2863621413707733, 0.2630671560764313, -0.4355900287628174, -0.03818649798631668, 0.050761252641677856, 0.1024196669459343, 0.17010237276554108, -0.01565929502248764, 0.016450945287942886, 0.09500664472579956, -0.37145310640335083, 0.3493816554546356, -0.23238494992256165, -0.08709325641393661, 0.12961533665657043, -0.267261266708374, 0.0810905396938324, -0.45309674739837646, 0.20151962339878082, 0.35885584354400635, 0.3757140338420868, -0.2908269762992859, 0.2851231098175049, 0.40066099166870117, 0.027996603399515152, 0.18582601845264435, -0.29461902379989624, 0.16669335961341858, -0.4466007649898529, -0.12424800544977188, 0.47227513790130615, 0.742011547088623, 0.29077601432800293, 0.20663636922836304, -0.09264665842056274, -0.10738818347454071, 0.1899675875902176, -0.023896349593997, 0.3751964867115021, 0.12337421625852585, -0.23346471786499023, 0.2694830000400543, -0.39138856530189514, -0.2597454786300659, 0.14595112204551697, -1.090085744857788, -0.46570637822151184, -0.0012022971641272306, -1.0234227180480957, 0.15636242926120758, -0.40017521381378174, -0.39401888847351074, -0.1377527266740799, -0.22123703360557556, -0.026487724855542183, 0.060985151678323746, -0.25536230206489563, 0.5257739424705505, -0.5470097661018372, 0.5694037675857544, -0.09261900931596756, -0.0061039552092552185, -0.3185160756111145, 0.04072987288236618, 0.3197956383228302, 0.007716326043009758, -0.3115864098072052, 0.08434423804283142, 0.2804327607154846, 0.07764340192079544, -0.1956074833869934, -0.11787696182727814, -0.5157715082168579, -0.1067933589220047, 0.3651971220970154, 0.03527013957500458, -0.11430535465478897, 0.31084999442100525, -0.18105879426002502, -0.5122920274734497, -0.17228521406650543, -0.18228046596050262, 0.24924927949905396, -0.5398666858673096, 0.44941505789756775, 0.32203710079193115, -0.15900281071662903, 0.11566727608442307, -0.3127332627773285, 0.19149823486804962, -0.03792930766940117, -0.39689895510673523, 0.030595673248171806, 0.6551698446273804, -0.6831884384155273, -0.5493761897087097, 0.12071261554956436, -0.3395245373249054, 0.3247467279434204, 0.25235944986343384, -0.2683967649936676, 0.06523291766643524, 0.5893557071685791, 0.058614592999219894, 0.04516592621803284, 0.44036078453063965, 0.2066064327955246, 0.2057187706232071, -0.32724013924598694, -0.09593628346920013, -0.08296732604503632, -0.5876743197441101, -0.9873967170715332, 0.03632846102118492, 0.22080057859420776, 0.46173295378685, 0.06599480658769608, -0.013330794870853424, -0.46943461894989014, -0.335590124130249, 0.20454028248786926, -0.17306339740753174, 0.39255213737487793, 0.2650873363018036, 0.4451499283313751, 0.09083718061447144, -0.08416242152452469, 0.4355386793613434, 0.39478251338005066, -0.4458228349685669, 0.709994375705719, -0.7128185629844666, 1.195181965827942, -0.602149486541748, -0.19358062744140625, 1.1898295879364014, 0.22030597925186157, -0.22734427452087402, -0.170491561293602, -0.19042463600635529, 0.25111883878707886, -0.036775149405002594, -0.38522517681121826, -0.05918994918465614, -0.38996273279190063, -0.15707391500473022, -0.3832380771636963, -0.05707119405269623, 0.18099486827850342, -0.556781530380249, -0.2817683815956116, 0.298303484916687, -0.0764206275343895, 0.10291922092437744, 0.09786345809698105, 0.5544930696487427, 0.049339570105075836, 0.12223950773477554, 0.7338753938674927, -0.14253732562065125, 0.30180031061172485, 0.35329899191856384, -0.22985021770000458, 0.167490616440773, 0.6649458408355713, 0.3860842287540436, 0.7661027908325195, -0.5064670443534851, 0.1770062893629074, -0.09461186826229095, 0.25166577100753784, 0.08664804697036743, 0.14881925284862518, 0.07449208199977875, -0.1622350960969925, -0.5108837485313416, 0.0020244582556188107, -0.45600762963294983, -0.15879486501216888, 0.3681889474391937, -0.11057312786579132, 0.1381402462720871, 0.398517906665802, -0.05155535787343979, -0.16783185303211212, 0.7705199718475342, -0.9537574052810669, 0.15390609204769135, 0.17289505898952484, 0.2146037369966507, 0.18139933049678802, -0.03295086696743965, -0.10928726196289062, -0.17905418574810028, -0.20461809635162354, -0.5981722474098206, 0.014767863787710667, -0.42435139417648315, 0.11177119612693787, 0.07462827116250992, 0.22997626662254333, -0.0003444969770498574, 0.3042639195919037, -0.882929801940918, -0.751592218875885, -0.6899101138114929, 0.20928964018821716, 0.379090815782547, 0.8641893863677979, -0.03983975946903229, -0.6151202321052551, 0.11796145141124725, -0.20092006027698517, -0.41323548555374146, 0.2229682058095932, 0.44645705819129944, -0.486295223236084, 0.030495136976242065, -0.08696368336677551, 0.443508505821228, 0.617228090763092, -0.10805071890354156, 0.02930867113173008, -0.08265082538127899, -0.19147641956806183, -0.07871757447719574, -0.0754653811454773, -0.21910889446735382, 0.462816059589386, 0.5831176042556763, -0.13070689141750336, -0.24965670704841614, 0.5502405762672424, 0.6242190599441528, -0.2826385200023651, 0.7313688397407532, 0.5343612432479858, 0.3111402988433838, 0.05782643333077431, 0.054758913815021515, -0.0900178849697113, 0.08085948973894119, -0.05182214081287384, -0.24251873791217804, -0.5660961866378784, 0.11545844376087189, -6.1081156730651855, 0.21711109578609467, -0.46033793687820435, -0.02848101407289505, -0.046783942729234695, 0.33433690667152405, 0.9154675602912903, -0.22484605014324188, -0.2622166574001312, 0.1977112889289856, -0.034784380346536636, 0.2508138418197632, 0.06116987019777298, 0.19900406897068024, 0.1571292132139206, 0.41331803798675537, 0.3977641761302948, -0.27310141921043396, 0.2187395691871643, 0.3058607280254364, 0.3456002473831177, -0.4315625727176666, -0.3417638838291168, 0.37214478850364685, -0.07140297442674637, 0.26732000708580017, -0.2609451413154602, 0.058011285960674286, -0.22107180953025818, -0.26568958163261414, -0.16201601922512054, -0.43140706419944763, -0.5755911469459534, -0.011523921974003315, 0.7302445769309998, 0.5190990567207336, 0.42300179600715637, 0.3170279562473297, 0.25765925645828247, -0.28805920481681824, 0.013282866217195988, 0.11811719834804535, -0.17220516502857208, -0.526013195514679, 0.004354081116616726, 0.26937082409858704, -0.10479365289211273, 0.010399824939668179, -0.3906475305557251, 0.1296125203371048, -0.11684509366750717, 0.04365969076752663, 0.11757766455411911, 0.6972812414169312, -0.012652257457375526, -0.13811959326267242, -0.3357641100883484, 0.28327539563179016, -0.07690928876399994, 0.3360745310783386, -0.3078773021697998, 0.0843142494559288, -0.4983224868774414, -1.0020288228988647, -0.16465461254119873, 0.2370930314064026, -0.45351049304008484, -0.348943293094635, 0.21807876229286194, 0.2895949184894562, -0.394226610660553, -0.05603707581758499, 0.26838815212249756, -0.7355245351791382, 0.13807149231433868, -0.3891867995262146, 0.4741164743900299, 0.11278483271598816, -0.12223334610462189, 0.0778348371386528, -0.1821979135274887, -0.16756317019462585, 0.07657888531684875, -0.005025248508900404, 0.57940274477005, -0.21052312850952148, -0.1981632262468338, 0.20391497015953064, -0.087490513920784, 0.050599705427885056, 0.40438181161880493, -0.1374334990978241, -0.1146160364151001, 0.4780503809452057, 0.18857592344284058, 0.4378826320171356, 0.21806012094020844, -0.029985906556248665, 0.5631936192512512, -0.4343888461589813, 0.6453427076339722, -0.08460171520709991, -0.1767270863056183, -0.729450523853302, -0.30499428510665894, 0.7010824084281921, -0.8032127022743225, 0.04551045596599579, 0.5763644576072693, -0.5374894738197327, -0.004758655093610287, -0.20782826840877533, -0.25203412771224976, -0.11441080272197723, 0.7976056337356567, -0.22361230850219727, -0.33559590578079224, 0.006745547987520695, 0.49864161014556885, 0.19300678372383118, -0.242511585354805, -0.2073451578617096, -0.6001386046409607, -0.19934943318367004, -0.3275870978832245, -0.4088936150074005, -0.15178099274635315, 0.24910372495651245, -0.66896653175354, 0.30647993087768555, 0.46348920464515686, 0.47543349862098694, -0.5262467861175537, 0.02719741500914097, -0.10786987841129303, -0.6646532416343689, -0.18177063763141632, 0.41676297783851624, -0.09807425737380981, -0.04373311623930931, 0.11909310519695282, -0.025336669757962227, 0.1854502409696579, 0.052029289305210114, 0.1722889542579651, -0.011025944724678993, 0.1872667670249939, -0.35903337597846985, -0.5934112071990967, -0.04757395014166832, 0.44162726402282715, -0.4594726860523224, -0.21587997674942017, 0.3761609196662903, -0.4623417258262634, 0.11935801059007645, 0.4898589253425598, 0.10373770445585251, 0.6330730319023132, -0.6890303492546082, 0.5174989104270935, -0.25180402398109436, -1.1199740171432495, -0.010586119256913662, 0.10452322661876678, -0.21917258203029633, -0.3097159266471863, -0.020691661164164543, 0.10315597802400589, 0.19347956776618958, 0.12051231414079666, -0.8021446466445923, -0.08497598767280579, -0.11848489195108414, 0.16820183396339417, -0.007314217276871204, -0.36435577273368835, -0.14525701105594635, -0.15592944622039795, 0.05987711250782013, 0.02354569174349308, -0.28069883584976196, -0.5193161964416504, 0.04852456972002983, 0.615673840045929, 0.31491315364837646, -0.02456575818359852, -0.2097219079732895, -0.2136770337820053, -0.37004196643829346, 0.5156154036521912, 0.016531899571418762, 0.7016813158988953, -0.14101095497608185, 0.17693734169006348, -0.16797640919685364, 0.35112497210502625, 0.5599262714385986, 0.06292099505662918, 0.0314783975481987, -0.020935101434588432, 0.003290195018053055, -0.17946510016918182, 0.4930988848209381, 0.831932783126831, -0.28536051511764526, -0.6212599873542786, -0.06762844324111938, -0.5539089441299438, -0.2862376868724823, -0.7025456428527832, -0.6162624955177307, -0.381451278924942, -0.26384851336479187, -0.44891437888145447, 0.32564231753349304, -0.0227225199341774, -0.6569786071777344, -0.12387656420469284, 0.3624340295791626, -0.02386903390288353, -0.07027114927768707, -0.5731599926948547, -0.4141506850719452, -0.2467268407344818, -0.4181743860244751, 0.5583290457725525, -0.7464724183082581, -0.2038590908050537, 0.2908920347690582, -0.15582258999347687, -0.040277834981679916, 0.07966433465480804, -0.0888507217168808, -0.06568724662065506, -0.3044223487377167, -0.5267691612243652, -0.028497042134404182, 0.012791544198989868, 0.09715833514928818, -0.12635721266269684, 0.7066821455955505, 0.16149339079856873, 0.14845773577690125, 0.04433227330446243, 0.16632984578609467, 0.2328934669494629, -0.4719223082065582, -0.1858055293560028, -0.06493116170167923, 0.12813229858875275, -0.04323306679725647, 0.25142621994018555, -0.04444460570812225, 0.9217960238456726, 0.1249002143740654, 0.1487996131181717, -0.5789070129394531, 0.3045543134212494, 0.5101667046546936, 0.06224118545651436, 0.007350056432187557, 0.04363381862640381, -0.1310996413230896, -0.09922204911708832, 0.31781095266342163, 0.19893591105937958, -0.5536255240440369, 0.3695726692676544, 0.004044840577989817, 0.48115378618240356, -0.10901450365781784, 0.023799292743206024, 0.5488155484199524, 0.1550033837556839, 0.12014000862836838, 0.04377557709813118, 0.09993452578783035, 0.155500128865242, 0.12516626715660095, -0.2788640558719635, -0.10962038487195969, 0.21772971749305725, -0.19804751873016357, 0.2818014323711395, -0.7984465956687927, -0.25265035033226013, -0.21092578768730164, -0.24805305898189545, -0.27044421434402466, -0.20165832340717316, 0.022268591448664665, -0.7155648469924927, -0.24198351800441742, -0.06365202367305756, 0.4202645421028137, -0.04809233173727989, 0.2111029177904129, -0.46072492003440857, -0.5020009279251099, -0.32558465003967285, 0.6828604340553284, 0.5883586406707764, 0.007317449431866407, -0.3221715986728668, 0.08133695274591446, 0.5996236205101013, -0.17125295102596283, -0.22634649276733398, -0.05692918971180916, 0.35216569900512695, 0.05239572376012802, 0.6241649985313416, 0.4315861463546753, -0.7415019869804382, -0.13147573173046112, -0.33218491077423096, 0.31306159496307373, 0.16482436656951904, 0.3782314658164978, 0.28376680612564087, 0.5571040511131287, 0.8578312993049622, -0.1249031126499176, -0.10315573215484619, 0.5936146378517151, 0.3082127273082733, 0.04500995948910713, 0.23703987896442413, 0.7569254636764526, 0.576759397983551, 0.41202282905578613, -0.049174390733242035, 0.8896353244781494, 0.16630221903324127, 0.3251090943813324, 0.1531597226858139, -0.17435656487941742, -0.4977404773235321, -0.06300882250070572, 0.8751909732818604, 0.18923135101795197, -0.3189025819301605, -0.03776973485946655, 0.053539808839559555, 0.17457951605319977, -0.04899086430668831, 0.34724539518356323, -0.03183235600590706, -0.08067172765731812, 0.3504021465778351, -0.145126610994339, 0.09310616552829742, 0.49846312403678894, -0.20856215059757233, -0.047331780195236206, 0.49544817209243774, -0.22108884155750275, -0.45383593440055847, 0.15279676020145416, 0.04347716644406319, 0.032696764916181564, -0.09020816534757614, 0.07046470046043396, 0.38611140847206116, -0.2727266252040863, 0.28075122833251953, 0.29731667041778564, 0.17705082893371582, 0.050627004355192184, -0.1583976000547409, -0.12502019107341766, -0.11077744513750076, -0.11729373037815094, 0.05153943598270416, -0.5785110592842102, -0.19300448894500732, -0.17804370820522308, 0.28151729702949524, 0.5033084750175476, -0.11977235972881317, -0.17099305987358093, -0.14249980449676514, -0.6619551181793213, -0.10505212843418121, 0.041136693209409714, -0.0017951317131519318, 0.2828589975833893, 0.1720607876777649, 0.14332419633865356, 0.3771417438983917, -0.4401116669178009, -0.3241982161998749, 0.15948310494422913, -0.06292355060577393, -0.22482779622077942, -0.6500779390335083, 0.24404364824295044, 0.7435994148254395, 0.0561048649251461, 0.09611024707555771, -0.056231893599033356, -0.3822312653064728, 0.35566556453704834, -0.24962705373764038, 0.41499632596969604, -0.5647243857383728, -0.1182299330830574, -0.6233649849891663, 0.03178848326206207, 0.5930393934249878, 0.08255960047245026, -0.009081609547138214, -0.0579165555536747, 0.471946120262146, 0.6389188766479492, 0.16237910091876984, -0.6489376425743103, -0.600795567035675, -0.0396440327167511, -0.18600469827651978, -0.2040969878435135, 0.4926384687423706, -0.36249616742134094, -0.5415067672729492, 0.15743647515773773, 0.1327040195465088, -0.31375637650489807, -0.18000859022140503, 0.38321998715400696, -0.15216894447803497, -0.4572359025478363, -0.42133328318595886, 0.3743779957294464, -0.8187137246131897, -0.3348890244960785, 0.24676015973091125, 0.038484252989292145, 0.0843660905957222, 0.09401342272758484, -0.38450443744659424, -0.4558996856212616, 0.2800270915031433, 0.320541650056839, 0.39223718643188477, -0.031717583537101746, 0.053831420838832855, -0.3525954782962799, -0.17176462709903717, 0.09370651841163635, -0.15640072524547577, -0.14716389775276184, -0.2410598248243332, -0.05481746420264244, -0.23664936423301697, 0.13756294548511505, -0.03895169496536255, -0.6454035043716431, -0.06476853042840958, -0.07845330238342285 ]
Myeloid-derived suppressor cells (MDSC) promote tumor growth by inhibiting T-cell immunity and promoting malignant cell proliferation and migration. The therapeutic potential of blocking MDSC in tumors has been limited by their heterogeneity, plasticity, and resistance to various chemotherapy agents. Recent studies have highlighted the role of energy metabolic pathways in the differentiation and function of immune cells; however, the metabolic characteristics regulating MDSC remain unclear. We aimed to determine the energy metabolic pathway(s) used by MDSC, establish its impact on their immunosuppressive function, and test whether its inhibition blocks MDSC and enhances antitumor therapies. Using several murine tumor models, we found that tumor-infiltrating MDSC (T-MDSC) increased fatty acid uptake and activated fatty acid oxidation (FAO). This was accompanied by an increased mitochondrial mass, upregulation of key FAO enzymes, and increased oxygen consumption rate. Pharmacologic inhibition of FAO blocked immune inhibitory pathways and functions in T-MDSC and decreased their production of inhibitory cytokines. FAO inhibition alone significantly delayed tumor growth in a T-cell-dependent manner and enhanced the antitumor effect of adoptive T-cell therapy. Furthermore, FAO inhibition combined with low-dose chemotherapy completely inhibited T-MDSC immunosuppressive effects and induced a significant antitumor effect. Interestingly, a similar increase in fatty acid uptake and expression of FAO-related enzymes was found in human MDSC in peripheral blood and tumors. These results support the possibility of testing FAO inhibition as a novel approach to block MDSC and enhance various cancer therapies.
[ 0.006507898680865765, 0.0007394287968054414, -0.0007563203107565641, 0.011984661221504211, 0.005380552262067795, -0.006083338521420956, 0.010853951796889305, -0.024823293089866638, -0.012080205604434013, -0.038967981934547424, -0.013075744733214378, 0.01357225887477398, 0.003942652139812708, 0.023573800921440125, -0.024654127657413483, 0.014525571838021278, -0.023896796628832817, 0.001956858905032277, 0.007037336938083172, 0.004597797989845276, 0.0016210400499403477, -0.0015039604622870684, 0.010567870922386646, -0.026268161833286285, 0.024459466338157654, 0.032236248254776, -0.0054982807487249374, -0.009042990393936634, -0.024675415828824043, -0.0010054211597889662, -0.01169821247458458, -0.008030334487557411, 0.03620993345975876, -0.010658256709575653, 0.017093800008296967, 0.009909150190651417, -0.00020242109894752502, 0.018774475902318954, 0.03387778624892235, -0.004908169619739056, -0.002209818223491311, -0.009958761744201183, 0.007489889860153198, 0.0008046162547543645, -0.007312510162591934, -0.01231472473591566, 0.0035840854980051517, -0.0074233682826161385, 0.0035360222682356834, 0.00816535297781229, -0.00980652030557394, -0.02551950514316559, -0.004486533347517252, -0.0019993730820715427, -0.006531304679811001, -0.0021324167028069496, 0.017755283042788506, -0.014283167198300362, 0.0113949254155159, -0.014472737908363342, 0.020916106179356575, -0.03855924308300018, 0.021516628563404083, -0.004577443469315767, -0.0012867997866123915, -0.06678497791290283, 0.008662357926368713, 0.006832601502537727, -0.0033216411247849464, -0.009811967611312866, 0.01495002955198288, 0.005586243234574795, -0.00942189246416092, -0.013146421872079372, -0.010782568715512753, 0.005667054560035467, -0.03035322017967701, 0.02169567532837391, 0.0032388046383857727, 0.036089129745960236, -0.006969761103391647, -0.021078946068882942, -0.008481300435960293, 0.016582559794187546, 0.008314100094139576, -0.006407937966287136, -0.02095109596848488, -0.015473023988306522, 0.005167744588106871, -0.009018512442708015, 0.005987604148685932, 0.015409156680107117, -0.007399265188723803, 0.011266606859862804, -0.01797092705965042, -0.016616415232419968, -0.0047418964095413685, 0.004007579758763313, 0.010267303325235844, -0.0037022882606834173, -0.01293353084474802, -0.016477424651384354, 0.015212280675768852, 0.016349440440535545, -0.023739565163850784, 0.007157878950238228, -0.03102000802755356, 0.012219798751175404, 0.034703560173511505, 0.013561450876295567, -0.02277904935181141, -0.008056568913161755, -0.01687791384756565, 0.01415233500301838, 0.016545841470360756, 0.005725750233978033, -0.017147250473499298, 0.03387020155787468, 0.012957565486431122, 0.01238980982452631, -0.003817007876932621, 0.013963362202048302, 0.013466132804751396, 0.0010903533548116684, 0.0035097720101475716, 0.033674441277980804, -0.033568136394023895, 0.005459630861878395, 0.012970048002898693, -0.005119701847434044, -0.008950518444180489, 0.00000268442090600729, 0.03379731997847557, -0.004725088831037283, -0.0004216821398586035, -0.007397813256829977, -0.007895242422819138, -0.010442445054650307, 0.009361203759908676, -0.016808781772851944, -0.01945025846362114, 0.010603314265608788, 0.0021562131587415934, 0.011673487722873688, -0.004192189313471317, -0.004006608854979277, -0.0022514797747135162, -0.0008475790964439511, -0.013217727653682232, 0.015758158639073372, 0.0014824364334344864, -0.001809575129300356, -0.008694134652614594, -0.01315149012953043, -0.0010533612221479416, 0.028155744075775146, -0.010462433099746704, -0.021922282874584198, 0.004447863902896643, -0.02006768062710762, -0.04302489757537842, -0.032716356217861176, 0.030216731131076813, 0.0090793427079916, 0.014570469036698341, -0.011273522861301899, -0.0028428207151591778, -0.004271636717021465, 0.017596740275621414, 0.005800951737910509, -0.007997549138963223, -0.0009550753748044372, -0.01928393729031086, 0.006051165051758289, -0.01020729262381792, 0.001960255205631256, 0.004465537611395121, 0.009540922939777374, -0.012581519782543182, 0.0667993500828743, 0.017397448420524597, 0.04426562786102295, 0.020623818039894104, 0.00514573697000742, 0.007708653807640076, -0.024729643017053604, 0.00006028544157743454, -0.005679910071194172, -0.03346501663327217, 0.008700505830347538, 0.006820686161518097, 0.009424472227692604, -0.041747987270355225, 0.018064888194203377, -0.02412288449704647, 0.003206566208973527, 0.006785450037568808, -0.002710451139137149, -0.00039334502071142197, -0.007485502865165472, 0.03154841065406799, -0.015272201038897038, 0.03510433807969093, 0.0010904180817306042, 0.020230861380696297, 0.010860291309654713, 0.0018892083317041397, -0.01874082162976265, 0.0029872707091271877, -0.0008751037530601025, 0.0034203743562102318, -0.002560898195952177, -0.009463418275117874, -0.0014150016941130161, 0.031441301107406616, 0.01677083410322666, -0.013738268986344337, 0.02035302296280861, -0.009552787989377975, -0.012200510129332542, -0.006194985006004572, 0.01051377598196268, 0.01977386325597763, -0.005651084240525961, 0.012887116521596909, -0.008482012897729874, 0.006022199057042599, 0.012139560654759407, -0.013435425236821175, 0.012499742209911346, -0.01432415097951889, -0.020278042182326317, -0.01124083437025547, 0.007869252935051918, -0.005853550508618355, 0.009346931241452694, 0.014886299148201942, 0.00905767921358347, 0.021338660269975662, -0.016776692122220993, 0.012285841628909111, 0.01191852055490017, 0.04080594331026077, -0.0077093844301998615, 0.015491186641156673, 0.01515008695423603, 0.025432856753468513, 0.02133602648973465, 0.03046378120779991, 0.007288404740393162, 0.006568669341504574, 0.0050683654844760895, 0.01500959973782301, -0.0018524774350225925, -0.0039261747151613235, -0.022825177758932114, -0.021493636071681976, 0.03589721769094467, 0.024514090269804, -0.02447664551436901, -0.0030692564323544502, 0.008222660049796104, -0.028547096997499466, 0.0168893001973629, -0.011023011989891529, 0.021512042731046677, 0.011361782439053059, 0.016036875545978546, 0.005572992376983166, 0.019301149994134903, 0.007609413005411625, -0.002602160442620516, 0.000173875130712986, -0.0814821720123291, -0.01745970919728279, 0.01525980606675148, 0.019856397062540054, 0.01424451731145382, -0.028737258166074753, -0.0032886266708374023, -0.006474084686487913, -0.016066353768110275, -0.0023671663366258144, 0.011129074729979038, 0.009825833141803741, -0.007358756847679615, -0.0080424714833498, 0.025295771658420563, -0.005582705605775118, 0.016574034467339516, -0.0036861542612314224, 0.003512053983286023, -0.00010885484516620636, 0.03740030154585838, -0.012075799517333508, 0.01731368899345398, -0.005378286819905043, -0.03699348866939545, 0.008051110431551933, 0.00687883235514164, -0.0077613601461052895, -0.02591409906744957, 0.0010754815302789211, -0.007726936135441065, 0.015024564228951931, 0.014400020241737366, 0.008278606459498405, -0.002106290776282549, 0.019712945446372032, 0.002510836347937584, 0.0015227687545120716, -0.015225499868392944, 0.04446454346179962, 0.00758635438978672, 0.006125764921307564, 0.024292662739753723, 0.00078014493919909, 0.020762493833899498, 0.012846584431827068, 0.024841492995619774, 0.01620020531117916, 0.013491694815456867, 0.0016141763189807534, 0.019634321331977844, 0.0007050298154354095, -0.014617910608649254, 0.015326889231801033, -0.021741770207881927, -0.038320839405059814, -0.013800611719489098, -0.02226535603404045, -0.013253016397356987, -0.012165052816271782, 0.02373654954135418, -0.03863970562815666, 0.021863438189029694, 0.05620303750038147, -0.0018057574052363634, 0.011336960829794407, 0.005788952112197876, 0.004335212055593729, -0.010227550752460957, 0.003157983534038067, -0.020503420382738113, 0.0012789302272722125, -0.006918315775692463, -0.001519245677627623, -0.0003189723938703537, -0.013575004413723946, -0.010502194054424763, -0.004727776162326336, 0.009041802957654, -0.02832941710948944, -0.02790895849466324, -0.0031754067167639732, -0.0351262167096138, -0.01323934830725193, -0.01775192841887474, -0.03902380168437958, 0.005868527106940746, 0.027697479352355003, 0.0011381423100829124, -0.011818531900644302, -0.006506511941552162, -0.0032325908541679382, -0.007810572162270546, 0.004690244793891907, 0.009585335850715637, 0.0020644953474402428, 0.0019526369869709015, -0.006204876583069563, 0.008581539615988731, 0.009885009378194809, -0.018602583557367325, 0.00463760644197464, 0.015825387090444565, -0.015142785385251045, -0.015253636986017227, 0.015412923879921436, 0.01455375924706459, -0.02940225601196289, 0.0022387211211025715, -0.002825196133926511, -0.014978773891925812, 0.021709557622671127, -0.004954641219228506, 0.026020478457212448, 0.011396566405892372, 0.006786600220948458, -0.003794521326199174, -0.0490032359957695, 0.07215550541877747, -0.012623066082596779, -0.0025943333748728037, -0.011653038673102856, 0.028073083609342575, -0.0250361617654562, -0.035179756581783295, 0.020929919555783272, -0.02408103086054325, 0.008154485374689102, 0.012839690782129765, 0.027015646919608116, 0.0019372263923287392, 0.014391331933438778, 0.005759219639003277, 0.01625114493072033, -0.03435713052749634, 0.006283711642026901, -0.007089380174875259, 0.00798147264868021, 0.00808972679078579, -0.0007868076208978891, 0.009564599953591824, 0.017722561955451965, -0.0031968937255442142, -0.039231881499290466, 0.016602884978055954, -0.00800940953195095, 0.00677281292155385, 0.00741023663431406, 0.000490852864459157, 0.023439377546310425, -0.0035661007277667522, -0.005632244050502777, 0.016241079196333885, 0.03606989234685898, 0.028835181146860123, 0.013735149055719376, -0.01771741732954979, 0.011208133772015572, -0.03516687825322151, -0.013734577223658562, 0.014012189581990242, 0.012983934953808784, -0.017149431630969048, -0.0053855436854064465, 0.031020138412714005, -0.005287081003189087, 0.0045122080482542515, -0.0005829557776451111, -0.017961222678422928, 0.0035581905394792557, 0.01534176990389824, 0.01540782768279314, 0.001467638649046421, 0.004024118185043335, 0.017818637192249298, 0.01263388991355896, 0.000005676178261637688, -0.013526401482522488, -0.03315183147788048, 0.014371296390891075, 0.029077766463160515, 0.002139417454600334, 0.012038585729897022, -0.013112787157297134, -0.025997133925557137, 0.009822937659919262, 0.034021295607089996, -0.017573799937963486, -0.0007903374498710036, 0.0027570538222789764, -0.007554348092526197, 0.004095158074051142, -0.011517170816659927, 0.037991002202034, 0.003100678091868758, 0.017815712839365005, 0.01226542703807354, 0.023378636687994003, -0.016021570190787315, -0.02820572443306446, 0.004113471135497093, 0.011359202675521374, 0.008371174335479736, 0.005998680833727121, -0.005981607362627983, -0.07470522820949554, 0.001383158378303051, -0.021586934104561806, -0.006798628251999617, 0.022280830889940262, 0.0019672014750540257, -0.019543446600437164, 0.008870206773281097, 0.02159770391881466, -0.0048803891986608505, 0.029895976185798645, 0.0037891697138547897, -0.02500981092453003, 0.0018106941133737564, 0.01150614395737648, -0.014683132991194725, -0.00045964354649186134, -0.005329737439751625, -0.02898426353931427, 0.0020870985463261604, 0.015081011690199375, 0.005408678203821182, -0.003080905880779028, 0.008437690325081348, -0.0025066332891583443, -0.0809953510761261, 0.009715983644127846, -0.02243865095078945, -0.025555621832609177, 0.0025880748871713877, -0.01402974035590887, -0.0034070357214659452, -0.02423226833343506, -0.033573754131793976, -0.015688147395849228, 0.006986980326473713, 0.014783110469579697, -0.002121944911777973, -0.022032488137483597, 0.016092916950583458, -0.008878344669938087, -0.004824853967875242, 0.000774754211306572, -0.016985997557640076, 0.020775383338332176, -0.0014496548101305962, 0.004459396470338106, -0.009623105637729168, -0.025173712521791458, -0.01975923404097557, -0.008428458124399185, 0.017024213448166847, 0.011460728012025356, 0.003298833267763257, 0.003687010845169425, 0.002776943612843752, -0.013779709115624428, -0.015026591718196869, -0.03653916344046593, 0.016114506870508194, -0.024316802620887756, -0.008014106191694736, 0.0032677212730050087, -0.020415009930729866, 0.005888446234166622, -0.009156981483101845, 0.007605968043208122, 0.020117036998271942, 0.02467156946659088, 0.03671013563871384, -0.01728668063879013, 0.006336989812552929, -0.0007789110532030463, 0.005967154633253813, 0.01862196810543537, 0.0007089959690347314, -0.001785079948604107, -0.004936474375426769, -0.002341538667678833, -0.012726906687021255, 0.009236696176230907, -0.006774798966944218, 0.023159295320510864, 0.009057611227035522, -0.0035432246513664722, 0.005097671411931515, -0.013235310092568398, -0.0035854773595929146, 0.07188509404659271, -0.004719007294625044, 0.029366860166192055, -0.031206564977765083, 0.004386095330119133, 0.004488058853894472, -0.04099174216389656, -0.014651268720626831, -0.01612117327749729, -0.005010366439819336, 0.0017944946885108948, 0.0003530806861817837, -0.012267028912901878, 0.0138785345479846, -0.006770002190023661, -0.029804620891809464, 0.025367073714733124, 0.019111033529043198, 0.00916422251611948, -0.0011395568726584315, -0.0014755520969629288, -0.02201772853732109, 0.005486868321895599, 0.015282485634088516, 0.03303385525941849, -0.017848089337348938, -0.052480436861515045, -0.009380956180393696, -0.007697904482483864, 0.004274403676390648, 0.011353151872754097, 0.025467868894338608, -0.004068567417562008, -0.002432395936921239, 0.017807869240641594, 0.044239290058612823, -0.007892237044870853, 0.0020743298809975386, -0.022017698734998703, 0.0011289636604487896, 0.018416352570056915, 0.019740240648388863, -0.00003111222758889198, -0.018543459475040436, -0.003236698918044567, -0.007609379477798939, -0.005819668993353844, -0.03756048530340195, -0.019647449254989624, 0.012767651118338108, 0.007814903743565083, 0.004303453024476767, -0.016418883576989174, -0.0050344886258244514, 0.019209686666727066, 0.020182523876428604, -0.022129159420728683, 0.007301070727407932, -0.004909888841211796, -0.027384456247091293, 0.007486295886337757, -0.010673275217413902, -0.010245894081890583, -0.014808492735028267, 0.01823565363883972, 0.04409392178058624, 0.007687513250857592, -0.009849284775555134, 0.04099314659833908, 0.01643824204802513, -0.020676124840974808, -0.04734097421169281, 0.009554317221045494, -0.011312359012663364, 0.020996229723095894, -0.004349162802100182, 0.024005504325032234, -0.017537064850330353, 0.02138211950659752, 0.005978808272629976, -0.016329510137438774, 0.04457689821720123, -0.0009237390477210283, 0.04088391363620758, -0.023933809250593185, 0.031779661774635315, 0.017041176557540894, 0.013378549367189407, -0.0023288533557206392, 0.011785640381276608, 0.018396973609924316, -0.0003134417347609997, -0.0010338006541132927, 0.025514209643006325, 0.0069688307121396065, 0.034188054502010345, 0.03380422294139862, 0.006092212628573179, 0.010174211114645004, 0.014024972915649414, 0.028547249734401703, -0.014944050461053848, -0.006654920522123575, -0.014560515061020851, -0.029266607016324997, -0.007170340046286583, 0.03162502497434616, -0.0004840632900595665, 0.019772080704569817, 0.034099746495485306, -0.007618412375450134, 0.004113389644771814, 0.0010035610757768154, 0.019649159163236618, -0.013978120870888233, 0.0021588033996522427, -0.014563513919711113, 0.02654327265918255, -0.014447042718529701, -0.011071424931287766, -0.0036626269575208426, -0.0004088606801815331, -0.0283174067735672, 0.009781230241060257, 0.009695908986032009, 0.012849707156419754, -0.016785908490419388, 0.0382668673992157, -0.02076100930571556, 0.012397956103086472, 0.004717666190117598, -0.005738869309425354, -0.0025797889102250338, 0.01155916228890419, 0.003674610983580351, 0.00511616375297308, -0.009343186393380165, 0.01842311955988407, -0.005216394085437059, 0.002655179239809513, 0.03436804562807083, -0.008901919238269329, 0.0013968900311738253, -0.01208909135311842, 0.008253629319369793, -0.00737254973500967, 0.014475398696959019, 0.0015103761106729507, 0.009704455733299255, -0.0013032197020947933, 0.01739305444061756, 0.02198781631886959, 0.013480398803949356, -0.005020101089030504, -0.009879864752292633, 0.03642430901527405, 0.01133735291659832, 0.01320569310337305, -0.008610745891928673, -0.012055568397045135, 0.0033330575097352266, -0.018082082271575928, 0.035543642938137054, 0.003814845345914364, 0.008540524169802666, 0.029295664280653, -0.013895542360842228, -0.00491960346698761, 0.00012373179197311401, 0.009705652482807636, 0.032751649618148804, -0.0006198203191161156, -0.0031101403292268515, 0.020333897322416306, -0.01553359441459179, -0.006908339448273182, -0.0236488226801157, -0.014963943511247635, 0.006972354371100664, 0.0031968788243830204, 0.014765242114663124, -0.02951846644282341, 0.0016684221336618066, -0.006444557569921017, -0.012342417612671852, 0.0076156239956617355, -0.022821880877017975, -0.022609759122133255, -0.005241082515567541, -0.03734220191836357, -0.0036359732039272785, -0.005465805064886808, 0.0077690789476037025, -0.008959641680121422, 0.0033475186210125685, -0.00971263274550438, 0.036466315388679504, -0.02146458625793457, 0.019590601325035095, -0.0028924273792654276, 0.005959338042885065, -0.013261562213301659 ]
[ 0.4425250291824341, 0.25825977325439453, -0.00504407798871398, 0.11702153831720352, 0.48081281781196594, -0.31706807017326355, 0.04490400478243828, 0.026307087391614914, -0.05779459699988365, -0.48262426257133484, 0.01682118885219097, 0.6216272711753845, -0.3221924901008606, 0.12340082228183746, -0.5386524200439453, 0.4147028625011444, 0.6500111222267151, 0.4447391629219055, -0.25145024061203003, -0.556179940700531, -0.42937833070755005, -0.0197260994464159, 0.49603915214538574, 0.227296844124794, -0.045267265290021896, -0.15646617114543915, 0.4320487678050995, 0.02034974843263626, 0.5817124247550964, -0.27590885758399963, 0.049786243587732315, 0.6053746938705444, 0.1596035361289978, -0.15222875773906708, 0.02449972741305828, 0.1998148113489151, -0.4240427315235138, 0.06972619146108627, -0.34541887044906616, -0.20485498011112213, -0.3803444504737854, -0.22559398412704468, -0.13907012343406677, 0.4254116415977478, -0.2287599891424179, -0.23033110797405243, -1.2566825151443481, 0.682384192943573, -0.2547804117202759, -0.2403918355703354, 0.15803050994873047, 0.09368694573640823, -0.024246681481599808, 0.31965839862823486, 0.6768909096717834, 0.16499260067939758, -0.8623361587524414, -0.3616386950016022, 0.566019594669342, -0.17970140278339386, 0.08244729042053223, -0.1749938279390335, -0.8172200918197632, -0.272958368062973, -0.25829532742500305, 0.436162531375885, 0.37308546900749207, -0.4021186828613281, -0.9239690899848938, -0.5805463790893555, 0.09579246491193771, -0.4813770353794098, 0.28534772992134094, 0.47834888100624084, -0.0020475757773965597, -0.1589484065771103, -0.1473890244960785, -0.44066762924194336, 0.3221985995769501, -0.31265485286712646, -0.010851585306227207, 0.42806652188301086, 0.3225753605365753, 0.15411895513534546, 0.008344626054167747, 0.21910880506038666, 0.21331405639648438, 0.9952256679534912, -0.2803976833820343, -0.35844430327415466, -0.2675729990005493, 0.3796708285808563, 0.6318067312240601, 0.12656110525131226, 0.2169511467218399, 0.3426700830459595, 0.12621597945690155, 0.04055790230631828, 0.1396847516298294, 0.43909814953804016, -0.4180629849433899, 0.1480633020401001, 0.02835613489151001, -0.14549753069877625, -0.5704233050346375, -0.29870912432670593, -0.010814358480274677, -0.26908358931541443, -0.7007678151130676, 0.17718607187271118, -0.7626197338104248, 0.09142395853996277, -0.8001499176025391, -0.6505133509635925, -0.07746510952711105, 0.17471832036972046, 0.2598491907119751, -0.2236289530992508, -0.45509791374206543, -0.055675867944955826, 0.3524075448513031, 1.793200969696045, -0.27988311648368835, 0.5119791030883789, 0.16385525465011597, -0.05202756077051163, 0.47445377707481384, 0.11873921751976013, -0.355823278427124, 0.5318508148193359, 0.16533072292804718, 0.64286208152771, -0.6419309973716736, 0.2632697820663452, 0.5963000059127808, -0.39756545424461365, 0.496283620595932, 0.04967395216226578, 0.6838314533233643, -0.13436152040958405, -0.6474806666374207, -0.958355188369751, -0.19286200404167175, 0.250539094209671, -0.4014793038368225, -0.45199820399284363, -0.2512630522251129, -0.17283859848976135, 0.20894812047481537, -0.4294171929359436, 0.2285379022359848, -0.2820577919483185, -0.8033818006515503, 0.18627017736434937, 0.35212817788124084, 0.6580728888511658, -0.07260729372501373, -0.41451573371887207, -0.09478363394737244, 0.44036903977394104, 0.0765412449836731, -0.2700948119163513, -0.1302114576101303, -0.21371592581272125, 0.5132702589035034, -0.1920195370912552, 0.42633119225502014, 0.4522590637207031, -0.06688201427459717, -0.14313751459121704, -0.8322502374649048, -0.42225566506385803, -0.4640001356601715, -0.7479562163352966, 0.5889250040054321, 0.1114804670214653, 0.5190842151641846, 0.2445107400417328, 0.028063325211405754, 0.1700054109096527, -0.8327872157096863, 0.1421087384223938, 0.061129599809646606, -0.6117655634880066, 0.6425793170928955, 0.315581738948822, 0.6909454464912415, 0.01080917939543724, 0.2525064945220947, -0.3074052333831787, -0.5156490802764893, -0.0632011815905571, 0.9977861642837524, -0.6373959183692932, 1.2701913118362427, 0.038461100310087204, 0.00575555395334959, 0.8061557412147522, -0.14024177193641663, -0.19382601976394653, 0.16801510751247406, 0.22414661943912506, 0.6147099137306213, -0.4299154579639435, -0.7807757258415222, -0.34168216586112976, 0.17224249243736267, -0.4595540761947632, -0.07454806566238403, 0.04316363483667374, 0.771752655506134, -0.481804221868515, 0.11722517758607864, -0.028417956084012985, 0.4729972183704376, -0.36089959740638733, -0.30810296535491943, 0.17510278522968292, -0.5940966010093689, -0.23755508661270142, 0.23467552661895752, -0.7919314503669739, 0.1684272587299347, 1.1905916929244995, 0.010259298607707024, 1.1143989562988281, 0.4014818072319031, -0.07587654888629913, 0.8220711946487427, 0.23448391258716583, 0.07263584434986115, -0.34030425548553467, -0.050346847623586655, -0.4155496656894684, -0.06497333943843842, 0.32851389050483704, -0.05143279209733009, -0.20026467740535736, 0.07738365232944489, -0.1548456996679306, 0.047992490231990814, -0.13927091658115387, -0.7400761842727661, -0.3949523866176605, 0.22165066003799438, -0.15277349948883057, -0.4954259693622589, 0.17670972645282745, -1.0603935718536377, -0.21202701330184937, -0.09120236337184906, 0.307429701089859, 0.5802921652793884, -0.6709443926811218, 0.19174621999263763, 0.42745622992515564, 0.011132746003568172, -0.1432458609342575, 0.3043028712272644, -0.7458587288856506, -0.4020412266254425, 0.11414382606744766, 0.09164292365312576, 0.15726889669895172, -0.15417443215847015, -0.4860454797744751, -0.3248129189014435, -0.25634852051734924, 0.5021589398384094, 0.46036016941070557, 1.0642096996307373, -0.283020943403244, -0.8741006851196289, -0.002858593128621578, -0.3113158047199249, -0.37611183524131775, 0.023044303059577942, 0.7864407896995544, -0.5974367260932922, -0.21787360310554504, 0.28960075974464417, 0.7161052227020264, 0.8101595640182495, -0.21703064441680908, -0.7403923869132996, 0.2796575427055359, -0.07870438694953918, -0.35828733444213867, -0.6931549906730652, -0.1681990623474121, -0.2827596068382263, 0.08057212084531784, -0.4671540856361389, 0.0028978828340768814, 0.2741774916648865, 0.1782255917787552, -0.15346568822860718, 0.18384762108325958, 0.33733808994293213, -0.05656516179442406, -0.2386731654405594, 0.10103996843099594, -0.08766734600067139, -0.08163750916719437, -0.42710280418395996, 0.01953023485839367, -0.5003862380981445, 0.7479170560836792, -5.62830114364624, -0.06018219143152237, -0.01359125878661871, 0.30540987849235535, -0.36198097467422485, -0.2792290449142456, 0.5312800407409668, -0.2981671094894409, 0.2850072681903839, -0.024893563240766525, 0.33043646812438965, 0.3545740842819214, -0.005941381212323904, -0.15523162484169006, -0.3847092390060425, -0.23623646795749664, 0.05362760275602341, -0.5933727622032166, 0.7934444546699524, 0.3747446835041046, 0.8497986197471619, -0.23607946932315826, -0.0934150442481041, 0.6352795362472534, -0.13452206552028656, 0.15581153333187103, -0.4806850254535675, 0.03331306576728821, -0.40133941173553467, -0.5924763679504395, -0.043168917298316956, -0.35108235478401184, 0.34147900342941284, -0.13041307032108307, 0.3048439621925354, 0.023447101935744286, 0.06488896161317825, 0.13518381118774414, -0.4024316370487213, -0.5803886651992798, 0.5109195113182068, -0.22277343273162842, -0.40970417857170105, 0.19652581214904785, 0.39247384667396545, 0.3335047960281372, 0.08910194784402847, 0.32855069637298584, -0.4645058214664459, 1.2301501035690308, 0.5579935908317566, -0.37886708974838257, 0.2445732206106186, 0.6471341848373413, 0.34934866428375244, 0.36541226506233215, -0.09418055415153503, 0.034621234983205795, -0.36287760734558105, 0.43996745347976685, -0.454409122467041, 0.08505658805370331, -0.2297498881816864, -0.21328839659690857, 0.0844731479883194, 0.500447154045105, -0.3929223418235779, -0.5024808049201965, 0.3982715904712677, -0.16625888645648956, -0.13942468166351318, 0.6073887944221497, 0.7719067335128784, -0.7147343754768372, 0.5575365424156189, -0.209568053483963, 0.25976893305778503, -0.09885838627815247, -0.07840874791145325, 0.39874616265296936, -0.11520592868328094, -0.09470551460981369, -0.20374366641044617, -0.5305607914924622, 0.1456640660762787, -0.5248802304267883, -0.06854557991027832, 0.5097658038139343, -0.1737273633480072, 0.32269778847694397, 0.40077194571495056, -0.1176862120628357, 0.3657974600791931, 0.3892783224582672, 0.7330707907676697, 0.40533772110939026, 0.3468584716320038, 0.5525313019752502, 0.7539494037628174, -0.05644610524177551, 0.5395547151565552, 0.1529535949230194, -0.17172600328922272, -1.003916621208191, -0.05098472908139229, -0.19945859909057617, -0.4914951026439667, -0.08114374428987503, 0.5321751832962036, -0.6133530139923096, 0.26300716400146484, -0.057866420596838, -0.5545419454574585, -0.41352328658103943, 0.8495739102363586, -0.5326005816459656, -0.010766598396003246, 0.31122562289237976, 0.9497547149658203, -0.2377692610025406, 0.3085384964942932, 0.5842780470848083, -0.6562522649765015, 0.002178920665755868, 0.2817195951938629, -0.04760130122303963, 0.2181585133075714, 0.9067689776420593, -0.5168876647949219, -0.2970137894153595, 0.2149198055267334, 0.4285213053226471, -0.28520676493644714, 0.10386890918016434, 0.16847553849220276, -0.39414548873901367, -0.5138564109802246, 0.33085933327674866, -0.06810585409402847, -0.19770167768001556, 0.6634224057197571, -0.3027574121952057, -0.14852343499660492, 0.17292693257331848, 0.3412737250328064, 0.19016462564468384, -0.34897515177726746, -0.1560625284910202, 0.04366862773895264, -0.19792518019676208, 0.1878248006105423, 0.1378459483385086, 0.06951913982629776, -0.06722523272037506, -0.05269303172826767, 0.608410656452179, 0.8716981410980225, -0.0848526656627655, 0.36547595262527466, -1.1264110803604126, 0.4229419529438019, 0.3357599675655365, -0.9306257963180542, 0.12467882037162781, -0.5558804869651794, 0.10889740288257599, -0.3745255470275879, -0.5943225026130676, 0.17335039377212524, 0.40453267097473145, -0.5776020884513855, -0.33870598673820496, -0.7074379920959473, 0.1440935581922531, 0.30311280488967896, -0.5906134843826294, -0.15980498492717743, 0.08666730672121048, -0.023910682648420334, -0.06594470888376236, 0.15207363665103912, -0.9200764894485474, 0.01005600020289421, 0.31318196654319763, 0.7663576602935791, 0.11739254742860794, 0.08349737524986267, -0.041161421686410904, -0.5354833602905273, -0.3354472815990448, 0.052225589752197266, 0.06929988414049149, 0.186457097530365, -0.4393237233161926, 0.5929315090179443, -0.08066000789403915, -0.11166463792324066, 0.1377028375864029, 0.27619320154190063, -0.6315690875053406, 0.08699546009302139, 0.44155991077423096, -0.26837754249572754, 0.21005354821681976, 0.40475988388061523, -0.06574558466672897, -0.309684693813324, 0.19484663009643555, -0.10101144015789032, -0.08362511545419693, -0.19628578424453735, -0.32978203892707825, 0.1984149068593979, 0.39962080121040344, -0.18432597815990448, 0.32890135049819946, -0.07304348051548004, -0.27284476161003113, -0.20984357595443726, 0.3282525837421417, 0.6096106171607971, -0.43933066725730896, -0.07576438039541245, -0.024538129568099976, -0.6049484014511108, 0.27781179547309875, 0.2142542600631714, -0.9561273455619812, 0.05308280512690544, 0.07462203502655029, -0.4157331883907318, -0.1687583029270172, -0.013044649735093117, -0.21794548630714417, -0.304126113653183, -0.38445115089416504, 0.14978745579719543, 0.5686245560646057, -0.21863429248332977, 0.47150030732154846, 0.3083937168121338, 0.6783987283706665, -0.7608733773231506, -0.06284791231155396, 0.11574360728263855, 0.6993247270584106, 0.49788331985473633, -0.575421929359436, -0.6915162801742554, 0.14969074726104736, 0.2515001595020294, -0.19394896924495697, 0.05906902998685837, 0.1403704434633255, 1.131786584854126, -0.15994015336036682, -0.020721064880490303, -0.5480291843414307, -0.37550392746925354, 0.016656264662742615, -0.38039740920066833, 0.122714564204216, 0.07369432598352432, -0.16150161623954773, 0.32549771666526794, -0.16709141433238983, 0.2807312309741974, -0.18687915802001953, 0.4744369387626648, -0.17813876271247864, -0.008325961418449879, -0.3841480612754822, 0.42958059906959534, 0.8509122133255005, -0.1865464597940445, 0.5694401860237122, -0.5133312344551086, -0.46457138657569885, -0.32994428277015686, 0.46298712491989136, -0.38580194115638733, -0.647527813911438, 0.04022186994552612, -0.4594087302684784, 0.517967939376831, -0.5480523109436035, 0.20108424127101898, -0.22155441343784332, -0.011584777384996414, -0.25038811564445496, -0.3292498290538788, -0.08539671450853348, -0.45543861389160156, -0.7472020983695984, -0.06268209964036942, 0.19960463047027588, -0.09039334207773209, -0.17080701887607574, -0.158704936504364, -0.22171249985694885, -0.46882814168930054, 0.46897706389427185, 0.35894322395324707, -0.28057238459587097, 0.22638241946697235, 0.2876390814781189, 0.18981024622917175, -0.06363492459058762, -0.3528115451335907, -0.2364235669374466, -0.1664901226758957, -0.30759814381599426, 0.3279733657836914, 0.1487114280462265, -0.29541435837745667, 0.24853774905204773, -0.3126283586025238, -0.0846685841679573, 0.216411754488945, 0.11573334038257599, 0.38695576786994934, 0.8065888285636902, 0.30610018968582153, -0.3718215525150299, -0.3495846092700958, 0.2973933219909668, -0.0894111692905426, -0.3047356903553009, 0.2983782887458801, 0.30688315629959106, 0.38402697443962097, 0.6527696847915649, -0.3476272225379944, 1.1148474216461182, 0.3528936803340912, 0.06557746976613998, 0.28882238268852234, -0.5016764998435974, -0.3461095988750458, -0.24024194478988647, 0.6287378668785095, 0.024089785292744637, -0.1477346569299698, 0.161265030503273, 0.15809307992458344, 0.43403562903404236, -0.07884521782398224, 0.11537109315395355, -0.2843363285064697, -0.14012043178081512, 0.06062804535031319, -0.4511573910713196, -0.5658878684043884, 0.2255496084690094, -0.25484827160835266, 0.19035594165325165, 0.12422438710927963, -0.44272273778915405, 0.056896597146987915, 0.27890557050704956, -0.2268678992986679, -0.13599373400211334, -0.2219676673412323, 0.5916742086410522, 0.23273995518684387, 0.08008788526058197, 0.0586591437458992, 0.07240016013383865, 0.27683839201927185, -0.10576673597097397, -0.21525029838085175, -0.12899905443191528, -0.06748276203870773, 0.18354764580726624, 0.3559524714946747, -0.2636295557022095, -0.2382315844297409, 0.18458999693393707, -0.0837923139333725, 0.2771523892879486, -0.22968360781669617, -0.017599623650312424, -0.10056331008672714, -0.7220035195350647, -0.3539491295814514, -0.18752163648605347, -0.17226473987102509, -0.16158300638198853, 0.4132741689682007, -0.25276434421539307, 0.41759997606277466, -0.7560117244720459, 0.2064666599035263, 0.03214886784553528, 0.5570628046989441, 0.23251979053020477, -0.0008912932826206088, 0.302090048789978, 0.1235952228307724, 0.3947206437587738, 0.16277708113193512, 0.3025785982608795, -0.30928999185562134, 0.3694712519645691, -0.9970629811286926, 0.31736475229263306, -0.32316821813583374, -0.3938681185245514, -0.6632134318351746, 0.011991399340331554, 0.814263641834259, 0.39700084924697876, -0.18973200023174286, 0.3120006024837494, 0.11405742168426514, 0.5652282238006592, 0.317859947681427, -0.4502522647380829, -0.2649548351764679, -0.6014641523361206, -0.08124125003814697, -0.23539523780345917, 0.826225221157074, -0.1627531349658966, -0.14635898172855377, -0.08955889940261841, 0.41333460807800293, 0.13817530870437622, -0.06956715881824493, 0.0716099888086319, -0.1935681253671646, 0.2607558071613312, -0.4579504132270813, 0.7380236983299255, -0.8572814464569092, -0.03247072175145149, -0.03622371703386307, -0.10135424882173538, -0.38262316584587097, -0.2726626694202423, 0.3527078926563263, -0.28152695298194885, -0.19903011620044708, -0.0205221027135849, 0.014964255504310131, -0.3823903501033783, 0.09487728029489517, -0.8906716108322144, -0.062062982469797134, 0.19588664174079895, 0.3163251578807831, -0.660018801689148, -0.11780594289302826, 0.016086898744106293, -0.030281448736786842, 0.5116870999336243, -0.07367165386676788, -0.41302403807640076, -0.23059600591659546, -0.18231649696826935 ]
PURPOSE To identify factors affecting the short-term prognosis of patients with acutely exacerbated chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS The 590 patients having COPD as primary disease who were hospitalized in the pneumology unit of a university hospital from 1981 to 1990 were studied. A standardized protocol for the treatment of acutely exacerbated COPD was adopted for all the patients. The patient records were retrospectively analyzed by two observers, and 23 clinical and laboratory variables defining the patient status on admission were collected. Age and arterial gas data were also taken into account, and the outcome mortality was recorded. Interobserver reproducibility was tested by computing the kappa coefficient and Spearman's rho for dichotomous and continuous variables, respectively. The relationship of clinical and laboratory factors to the outcome was assessed first by univariate analysis and then by a logistic regression analysis assessing the independent predictive role of variables previously shown to be univariately correlated with mortality. RESULTS The mortality rate was 14.4%. The logistic regression analysis identified four independent predictors of death: age (odds ratio [OR] 1.07; 95% confidence interval [CI] 1.04 to 1.11), alveolar-arterial oxygen gradient greater than 41 mm Hg (OR 2.33; 95% CI 1.39 to 3.90), ventricular arrhythmias (OR 1.91; 95% CI 1.10 to 3.31), and atrial fibrillation (OR 2.27; 95% CI 1.14 to 4.51). CONCLUSIONS Patients with acutely exacerbated COPD having a high risk of death can be identified at the time of admission. Variables reflecting heart dysfunction are important determinants of this risk. Among pulmonary function data, only alveolar-arterial oxygen gradient contributes to the predictive model.
[ 0.004974614828824997, 0.010541504248976707, -0.024398023262619972, 0.024305477738380432, -0.025026582181453705, 0.007913493551313877, 0.009776599705219269, 0.017801426351070404, -0.012100175023078918, -0.02254318632185459, -0.003544366452842951, 0.00466759130358696, 0.010980326682329178, 0.009656970389187336, -0.00945841334760189, 0.019656509160995483, -0.01332065463066101, 0.03157034516334534, 0.00807171780616045, -0.01156393438577652, -0.0006484976038336754, -0.0032246909104287624, 0.01154129859060049, 0.04703904315829277, -0.021255318075418472, -0.003975201398134232, -0.008601612411439419, -0.000898703234270215, 0.009063438512384892, 0.005407305900007486, -0.011449923738837242, 0.01901317574083805, -0.021578045561909676, 0.019940556958317757, 0.011840594001114368, -0.03276526927947998, 0.0013367655919864774, 0.00863226130604744, -0.030728710815310478, -0.00489439070224762, -0.009287625551223755, -0.01541479304432869, -0.00022005836945027113, 0.007225576788187027, -0.008292965590953827, -0.006336464546620846, -0.0045146518386900425, -0.025682352483272552, 0.0026654135435819626, 0.014371272176504135, -0.010317539796233177, 0.014953250996768475, -0.011880714446306229, -0.02412397600710392, -0.007431745063513517, -0.016535723581910133, 0.021084297448396683, 0.020227769389748573, -0.022993899881839752, 0.021905560046434402, 0.0005360334180295467, 0.009819342754781246, 0.01860283873975277, -0.010197369381785393, -0.008287208154797554, -0.06703413277864456, 0.03604727238416672, -0.0016099419444799423, 0.0017383978702127934, -0.008114894852042198, -0.021194208413362503, 0.008049802854657173, 0.006675303913652897, -0.003656683024019003, 0.0017764810472726822, -0.009079684503376484, 0.013005750253796577, 0.027862295508384705, 0.03531431406736374, 0.006093788892030716, -0.025004420429468155, -0.009276778437197208, -0.03619685024023056, 0.029508549720048904, -0.01042691059410572, -0.009256123565137386, -0.02086881548166275, -0.0006681371014565229, 0.01714181900024414, 0.017063751816749573, 0.03378988057374954, -0.0397961288690567, -0.021020999178290367, -0.011335184797644615, -0.0039971331134438515, -0.015336740761995316, -0.0289866141974926, 0.01704138144850731, -0.0014296150766313076, -0.03485523909330368, -0.01279597356915474, -0.0068775974214077, 0.02379310131072998, 0.0021914499811828136, -0.019382068887352943, 0.005002295132726431, -0.018473919481039047, 0.011151902377605438, 0.0014709427487105131, 0.004584888927638531, 0.005990378558635712, 0.02713761292397976, 0.020775148645043373, -0.015213019214570522, 0.03088158182799816, 0.006402103696018457, 0.010765569284558296, 0.020230093970894814, 0.014018804766237736, 0.0034199971705675125, 0.03604048490524292, 0.01083254162222147, -0.007010838948190212, 0.012020889669656754, -0.004800507798790932, 0.006628768052905798, 0.0017276047728955746, -0.005540475249290466, -0.010291063226759434, 0.010355036705732346, -0.005903176032006741, -0.019111160188913345, 0.0020639034919440746, 0.017855171114206314, 0.013479861430823803, 0.003303525038063526, -0.005574836395680904, -0.01801402121782303, -0.00498535018414259, 0.001159297302365303, -0.009592784568667412, 0.00387813663110137, -0.008889077231287956, 0.020000707358121872, -0.008165408857166767, 0.02211013436317444, 0.011953567154705524, -0.009213609620928764, 0.021362794563174248, 0.00002763606607913971, 0.0017502857372164726, -0.00871456228196621, -0.006959598511457443, -0.0227900929749012, 0.0022328803315758705, -0.02027103304862976, -0.005807414650917053, -0.011953042820096016, 0.0059530651196837425, 0.01661171391606331, -0.01395486295223236, -0.005300162360072136, 0.00491116801276803, 0.008613056503236294, 0.027271078899502754, 0.00750605296343565, 0.010016133077442646, 0.00782970990985632, -0.023232154548168182, -0.00027019233675673604, -0.004501542076468468, -0.002603609347715974, -0.036926403641700745, 0.015333377756178379, 0.012049063108861446, -0.008455383591353893, -0.013993114233016968, 0.007614486385136843, -0.010937982238829136, 0.0664886087179184, -0.012648449279367924, 0.007101038005203009, -0.0023222616873681545, -0.012603117153048515, -0.0010182964615523815, 0.0024074907414615154, -0.003969008103013039, -0.0028148191049695015, -0.000034825876355171204, -0.023633044213056564, 0.009357301518321037, 0.01060547586530447, 0.0029151018243283033, 0.0033845705911517143, 0.02680266462266445, 0.00473782466724515, -0.014423402957618237, 0.005772473756223917, -0.010402370244264603, 0.0005437685176730156, 0.007021991536021233, 0.0030585196800529957, 0.031587548553943634, 0.008230885490775108, 0.009778096340596676, 0.01695079356431961, -0.00775148905813694, -0.02237618900835514, -0.006239972077310085, 0.007628500461578369, 0.03389846533536911, -0.011593157425522804, 0.010105215013027191, -0.010930860415101051, -0.005187098402529955, -0.002942832186818123, -0.013231504708528519, 0.003077905625104904, -0.03165532648563385, -0.01604597643017769, -0.0002169508661609143, 0.013058099895715714, -0.008404009975492954, 0.010170784778892994, -0.018455224111676216, 0.013484523631632328, 0.005119366571307182, 0.005945523269474506, 0.017011728137731552, -0.005641411989927292, 0.006227150093764067, -0.009599409997463226, -0.008891782723367214, -0.022922879084944725, 0.022743087261915207, 0.015130489133298397, 0.014557436108589172, -0.018386313691735268, 0.007438465021550655, -0.014900308102369308, -0.013267314992845058, -0.008707200177013874, 0.022551625967025757, 0.018764980137348175, 0.004256023094058037, -0.012939933687448502, -0.0022868565283715725, -0.002368344459682703, 0.019139403477311134, -0.010705165565013885, 0.00845271535217762, 0.009829122573137283, 0.004045551642775536, 0.00564943253993988, 0.02470625564455986, -0.00952848605811596, -0.006115667521953583, -0.006784688215702772, 0.02561868354678154, -0.028920894488692284, 0.01172235794365406, 0.005318386480212212, 0.01586899720132351, -0.014936599880456924, -0.006249099969863892, 0.009889759123325348, 0.012682311236858368, -0.014418235048651695, 0.021798044443130493, 0.009558896534144878, 0.009212947450578213, -0.0036805174313485622, -0.007378906011581421, -0.08144409954547882, -0.007096068933606148, -0.019428636878728867, 0.03104887157678604, 0.006027802359312773, 0.012398744933307171, -0.0024000443518161774, 0.010815365239977837, -0.005545639432966709, 0.019974112510681152, 0.011536229401826859, -0.00002927985042333603, -0.00723990797996521, 0.014734828844666481, 0.0037502460181713104, -0.0012406527530401945, 0.0003619083436205983, 0.0208918247371912, -0.002129706321284175, -0.007989035919308662, -0.01606781780719757, 0.001991103170439601, 0.017372455447912216, -0.023458771407604218, -0.00611513527110219, 0.02436530962586403, -0.01018378883600235, -0.013025329448282719, 0.0021644686348736286, -0.005357739049941301, 0.02114832028746605, -0.01630215346813202, 0.01276834961026907, -0.033855415880680084, -0.031025070697069168, 0.0026176106184720993, 0.0012458653654903173, -0.019435212016105652, -0.00890821497887373, -0.0022777696140110493, 0.01339820958673954, 0.013321470469236374, -0.00824534147977829, 0.001756379147991538, -0.0006460261065512896, -0.0013123441021889448, 0.031292472034692764, -0.02587146684527397, 0.018201738595962524, -0.00526302820071578, -0.018869517371058464, 0.0027901753783226013, 0.009894896298646927, 0.009204808622598648, -0.015505156479775906, -0.012459279969334602, -0.006032759789377451, 0.0005219895392656326, -0.012243539094924927, -0.008634140715003014, -0.012500869110226631, -0.018269404768943787, 0.01348058134317398, -0.022833647206425667, 0.0058916048146784306, -0.021939845755696297, 0.012887796387076378, -0.010531443171203136, -0.004643598105758429, 0.008747296407818794, 0.02273523434996605, -0.014785943552851677, -0.011636968702077866, -0.010749995708465576, 0.03492045775055885, -0.006712930276989937, -0.015086596831679344, -0.0003180385974701494, 0.012118673883378506, -0.018598433583974838, -0.007527584675699472, -0.0037146215327084064, 0.008537622168660164, 0.011235826648771763, 0.00595463439822197, 0.010472829453647137, 0.019491633400321007, 0.01365191675722599, 0.02008063904941082, -0.014536537230014801, -0.033256128430366516, 0.02378743328154087, -0.02033868245780468, 0.009481620974838734, 0.012787900865077972, -0.0020536836236715317, 0.01125438790768385, -0.0134842898696661, 0.02331560291349888, 0.010453253984451294, -0.00100634153932333, 0.003400505753234029, -0.018744410946965218, -0.013565564528107643, -0.025764215737581253, 0.011293468996882439, 0.004806450102478266, 0.015386058017611504, -0.009050197899341583, -0.006215858273208141, -0.011295532807707787, -0.0020320662297308445, 0.0019700070843100548, 0.024988949298858643, 0.013102859258651733, 0.011464135721325874, 0.009087622165679932, 0.013258272781968117, 0.07200770825147629, 0.0074171447195112705, -0.007311379071325064, -0.018058419227600098, -0.0013730229111388326, -0.020213186740875244, -0.030014973133802414, 0.0016385340131819248, 0.024005256593227386, 0.008988837711513042, 0.013261701911687851, -0.01034958753734827, -0.0055094496347010136, -0.023535743355751038, -0.013457991182804108, -0.005227020941674709, -0.036124683916568756, 0.005200767889618874, 0.0019132471643388271, 0.0017754097934812307, 0.0048843142576515675, 0.0021601440384984016, -0.005283602047711611, -0.00852496549487114, 0.004830626305192709, -0.0165714044123888, 0.0011085858568549156, -0.013337366282939911, -0.014670364558696747, 0.010668894276022911, 0.006187294609844685, 0.010196492075920105, -0.006224191747605801, 0.008603856898844242, -0.017489008605480194, -0.0028720032423734665, 0.007918793708086014, 0.0012161682825535536, 0.007890419103205204, 0.0012803003191947937, -0.01721174456179142, -0.010408222675323486, -0.0006494838744401932, 0.012781919911503792, 0.008755028247833252, 0.0048203798942267895, 0.02172827161848545, -0.006494956091046333, -0.026625415310263634, -0.0016407058574259281, -0.024108082056045532, -0.0009490640368312597, 0.012330973520874977, 0.008680232800543308, -0.010777544230222702, -0.015212645754218102, -0.021603375673294067, -0.00214146776124835, -0.008570589125156403, 0.007506086491048336, -0.017592450603842735, -0.024024581536650658, -0.006302209105342627, -0.010649045929312706, -0.038110099732875824, 0.005573383532464504, 0.014279976487159729, -0.012511208653450012, -0.011269563809037209, 0.012330695055425167, 0.004536908119916916, 0.027409851551055908, -0.023859642446041107, -0.01595940813422203, -0.02356027439236641, 0.00660808477550745, 0.007413088344037533, 0.009180964902043343, 0.01839916780591011, -0.036509960889816284, -0.01509370282292366, 0.04101042449474335, 0.01999196782708168, -0.015058274380862713, 0.027882438153028488, -0.007010513450950384, -0.020093489438295364, -0.07446280121803284, -0.011280663311481476, 0.009504054673016071, -0.012340088374912739, -0.00786305870860815, 0.014805947430431843, -0.014479642733931541, -0.005569242872297764, 0.00744935218244791, -0.005877145566046238, -0.02106216736137867, -0.003047645790502429, 0.0008157915435731411, -0.013418100774288177, 0.014344895258545876, 0.00744347320869565, -0.014511472545564175, 0.006746782921254635, -0.0011388803832232952, 0.023330621421337128, -0.008367504924535751, 0.02496328577399254, -0.025286201387643814, -0.009391410276293755, -0.006056369282305241, -0.080955870449543, -0.024492386728525162, -0.01945214346051216, -0.0006294874474406242, 0.011293877847492695, -0.011174136772751808, 0.01968928426504135, -0.020782267674803734, 0.00640114676207304, -0.01532147265970707, -0.00888880155980587, 0.011083146557211876, 0.03563563525676727, -0.01621313765645027, 0.031825222074985504, -0.005087604746222496, 0.019125059247016907, 0.022547205910086632, -0.004324097186326981, -0.01891442760825157, 0.003119508735835552, -0.017140813171863556, -0.0031079649925231934, 0.004409936256706715, -0.005389714613556862, -0.0174922626465559, 0.005769731942564249, 0.013340240344405174, 0.018786190077662468, -0.02984502911567688, 0.01786591298878193, -0.010058393701910973, -0.01811528205871582, 0.022564683109521866, 0.010841140523552895, -0.012719373218715191, 0.002238004468381405, -0.005298708565533161, 0.0375296026468277, -0.003786929650232196, -0.005039501003921032, -0.02068965695798397, -0.01460149697959423, -0.010926052927970886, -0.005354610737413168, -0.004139402415603399, 0.008926695212721825, -0.016465608030557632, 0.005465907976031303, 0.017109718173742294, 0.0028826550114899874, 0.011682068929076195, 0.02517121098935604, 0.010010098107159138, -0.013909759931266308, -0.020588725805282593, -0.010733289644122124, -0.004820358008146286, 0.0018617744790390134, -0.005502999294549227, -0.0030453838407993317, 0.0004988639848306775, -0.008430958725512028, 0.07166511565446854, -0.03168543800711632, 0.002139155985787511, -0.010419240221381187, -0.005080243572592735, -0.004945562221109867, 0.016977297142148018, 0.000013140961527824402, -0.03132038936018944, 0.0009385854937136173, 0.022443272173404694, 0.0010761957382783294, 0.013539898209273815, 0.0051314616575837135, 0.035024866461753845, 0.016065724194049835, 0.0102275051176548, 0.001045622630044818, -0.018444735556840897, -0.02535278908908367, 0.0019379337318241596, 0.032313719391822815, -0.005926731042563915, 0.019276052713394165, -0.0029393527656793594, -0.009208375588059425, 0.02131487801671028, -0.023705553263425827, 0.018978198990225792, 0.0008237813599407673, -0.012427499517798424, 0.009980208240449429, 0.01054084300994873, 0.012798110023140907, 0.023665577173233032, 0.022716078907251358, -0.021879246458411217, 0.013035416603088379, -0.001458999002352357, 0.02921338751912117, -0.003430980956181884, 0.006524285301566124, 0.0073841954581439495, 0.011597469449043274, 0.02345067262649536, -0.03357284516096115, 0.024894805625081062, -0.005760339554399252, -0.007155395112931728, 0.006107340566813946, -0.03611240163445473, 0.0052223410457372665, 0.006425455678254366, 0.0028396770358085632, 0.012200675904750824, 0.004107160493731499, -0.01153193786740303, 0.014541305601596832, 0.013807951472699642, -0.015380697324872017, -0.0060360487550497055, -0.012397389858961105, 0.023220250383019447, -0.01681893691420555, -0.004323313478380442, -0.013781500980257988, 0.01754290610551834, -0.013166356831789017, -0.029718026518821716, 0.008591274730861187, 0.005384426563978195, 0.024493277072906494, 0.0065064942464232445, -0.019229356199502945, 0.018516268581151962, -0.005644885823130608, -0.0074842544272542, 0.0047161029651761055, 0.01927836239337921, 0.001152974320575595, -0.007820365950465202, 0.003682438051328063, -0.011335010640323162, -0.00905859749764204, -0.02255065366625786, -0.004634483717381954, 0.0081856120377779, 0.00808901060372591, -0.01409926638007164, 0.004392590839415789, 0.010589668527245522, 0.0037583813536912203, -0.0009203784866258502, 0.004064201842993498, 0.010263623669743538, 0.03445562720298767, -0.003688085824251175, -0.002354480093345046, 0.02547195553779602, -0.0008836726192384958, -0.0008312368881888688, 0.00506389606744051, 0.0005088385660201311, -0.004504456650465727, -0.028069064021110535, -0.008050703443586826, 0.002416139468550682, -0.010281680151820183, -0.008913358673453331, -0.00409723399206996, -0.008427195250988007, -0.005144878290593624, 0.028549913316965103, 0.017664864659309387, 0.01820090040564537, 0.018467752262949944, -0.00864998996257782, -0.026029221713542938, 0.008001342415809631, -0.013277711346745491, -0.010832127183675766, 0.0036056272219866514, -0.005352373234927654, 0.01652761921286583, -0.007993324659764767, -0.023816868662834167, 0.00050582573749125, -0.021369384601712227, 0.00668367138132453, -0.024466414004564285, -0.0016035933513194323, 0.017101231962442398, -0.013569848611950874, 0.029232561588287354, 0.001588619314134121, -0.009706235490739346, 0.0017036327626556158, -0.0006091315299272537, -0.013020574115216732, 0.010027622804045677, 0.010899041779339314, -0.005901927128434181, 0.0025834012776613235, -0.012067154981195927, 0.012082163244485855, -0.0017482684925198555, 0.005244127009063959, 0.02753116935491562, 0.01191359106451273, -0.0006770645268261433, -0.004504228010773659, -0.0027504542376846075, -0.0065774451941251755, -0.0016210854519158602, -0.01349700428545475, 0.0072412556037306786, 0.0030434648506343365, 0.031268466264009476, -0.027603428810834885, -0.014236642979085445, -0.004956904333084822, -0.020664718002080917, -0.016184743493795395, -0.012996591627597809, 0.003342640120536089, 0.008990094065666199, -0.021836061030626297, 0.025355208665132523, 0.003410139586776495, -0.01225452683866024, 0.009658459573984146, -0.006165911443531513, -0.017832081764936447, 0.03411119431257248, -0.02667814865708351, -0.010361949913203716, -0.0018795356154441833, -0.003551372792571783, 0.01713472791016102, 0.00919331330806017, 0.010305854491889477, 0.014125416055321693, 0.011953637935221195, -0.011885590851306915, -0.008078271523118019, -0.023477744311094284, -0.010448797605931759, 0.004832569509744644, -0.00216858834028244, -0.005451104138046503, -0.024570941925048828, 0.0006199982017278671, -0.01721777394413948, 0.00016723049338907003, -0.0027809985913336277, 0.009520746767520905, 0.0047459593042731285, -0.021666569635272026, -0.00007536588236689568, 0.004163363017141819, 0.023459352552890778, -0.01081950031220913 ]
[ 0.28852972388267517, 0.24591326713562012, 0.24919776618480682, -0.017676131799817085, 0.08677254617214203, 0.25055691599845886, 0.2134677916765213, -0.5070613026618958, -0.0954820066690445, -0.17705167829990387, 0.3220747709274292, 0.6098172664642334, 0.16299980878829956, -0.06849722564220428, 0.10427748411893845, 0.21770918369293213, 0.6332119107246399, 0.04271065443754196, 0.09861443936824799, -0.5509882569313049, -0.1943201869726181, -0.10834693163633347, 0.056750860065221786, -0.177091583609581, 0.062206801027059555, 0.3866331875324249, 0.29601752758026123, -0.23014210164546967, -0.21215400099754333, 0.015244128182530403, 0.15397405624389648, 0.1474054902791977, 0.12920264899730682, -0.5465038418769836, -0.4441080093383789, 0.42436379194259644, 0.17931637167930603, -0.017031555995345116, -0.0264391228556633, -0.5939738750457764, -0.2978742718696594, -0.13894395530223846, -0.07143524289131165, 0.18846192955970764, -0.14906132221221924, -0.1664118617773056, -1.299033761024475, -0.16579876840114594, -0.26794177293777466, 0.29521721601486206, 0.23381157219409943, 0.16751618683338165, 0.4881940186023712, 0.5093643665313721, -0.3225226104259491, 0.25549325346946716, -0.023379746824502945, -0.12590472400188446, -0.14736585319042206, -0.5570950508117676, 0.07790198177099228, -0.2839810848236084, 0.3974493145942688, 0.5090055465698242, -0.11671148985624313, 0.5469592213630676, 0.10710283368825912, 0.24130664765834808, 0.10638982057571411, -0.1650349348783493, 0.1330142319202423, -0.10966359823942184, -0.2245330661535263, 0.21330302953720093, -0.21797610819339752, -0.20908388495445251, 0.08095566183328629, -0.41770195960998535, -0.02340092696249485, 0.5630728602409363, 0.03281763195991516, 0.013020017184317112, -0.04801212623715401, -0.5623495578765869, 0.451455295085907, -0.01646554097533226, 0.051421891897916794, 0.3469749689102173, -0.24001912772655487, 0.38332420587539673, 0.28632187843322754, -0.3009706735610962, 0.5024476051330566, 0.01308817882090807, 0.2716878652572632, 0.29919543862342834, 0.5374407768249512, -0.01989424042403698, 0.12279485911130905, 0.08475394546985626, -0.1123104989528656, 0.4190858006477356, -0.5934168100357056, -0.13673724234104156, -0.3417471945285797, 0.0754212737083435, 0.1178831085562706, -0.861336886882782, -0.6815348267555237, 0.3097924590110779, -0.4487423002719879, -0.12156090140342712, 0.0187244713306427, 0.05544596537947655, -0.5185752511024475, 0.32362648844718933, 0.6391437649726868, -0.1480225771665573, -0.0674019455909729, 0.5320620536804199, -0.2163400650024414, 0.4197255074977875, 0.12674972414970398, 0.21135574579238892, 0.06984156370162964, 0.14216849207878113, 0.7631011605262756, 0.35595062375068665, -0.47234076261520386, 0.2724151611328125, -0.2573256492614746, 0.35741665959358215, 0.10008090734481812, -0.12627193331718445, -0.09275632351636887, -0.3401202857494354, 0.15599673986434937, 0.13835404813289642, 0.05002179369330406, 0.2796784043312073, -0.2817451059818268, -0.7802926898002625, -0.41737890243530273, -0.33828121423721313, -0.2804381251335144, -0.5936885476112366, 0.13110552728176117, -0.0025285053998231888, -0.16812677681446075, 0.16508851945400238, 0.3345261216163635, 0.3713345229625702, -0.09563999623060226, -0.17098742723464966, -0.018014635890722275, 0.7432870268821716, -0.4736676514148712, 0.0896306112408638, -0.07263123244047165, -0.16099999845027924, 0.4691389203071594, 0.3693435490131378, -0.26245132088661194, 0.1891731470823288, 0.18870684504508972, 0.21866966784000397, -0.229735866189003, 0.18930475413799286, 0.5294721722602844, -0.38347914814949036, -0.06287149339914322, -0.7107377052307129, -0.08938197791576385, -0.5803351402282715, -0.18643173575401306, 0.5376765727996826, 0.8248687386512756, 0.1579936444759369, -0.02424001134932041, 0.3958866596221924, -0.4593982398509979, 0.34411555528640747, -0.21230898797512054, -0.7987916469573975, 0.2076035737991333, -0.2929812967777252, 0.3595816195011139, -0.047869205474853516, 0.19040723145008087, 0.2505832016468048, -0.16789288818836212, -0.3925223648548126, 0.3101552426815033, -0.9873401522636414, 1.5483635663986206, -0.3576048016548157, -0.18330569565296173, 0.8212983012199402, -0.32982268929481506, -0.05818451941013336, 0.23459523916244507, 0.33196383714675903, 0.7118903398513794, -0.005717859137803316, -0.6098692417144775, -0.2732760012149811, -0.022712793201208115, -0.3576134741306305, -0.4329858124256134, 0.30779212713241577, 0.013010944239795208, -0.13830386102199554, -0.051516588777303696, -0.44544482231140137, 0.12550543248653412, -0.022291332483291626, -0.0997338816523552, 0.12957750260829926, 0.21494059264659882, 0.08917365223169327, 0.7043942213058472, -0.26334211230278015, 0.21549701690673828, 0.7823599576950073, -0.14248418807983398, 0.3442439138889313, 0.34975466132164, 0.015918785706162453, 0.5358340740203857, -0.7579887509346008, 0.4710529148578644, 0.1688005030155182, 0.36735275387763977, -0.6096113920211792, 0.08024551719427109, 0.08271072804927826, 0.10573318600654602, -0.12234551459550858, -0.21541215479373932, -0.003856923198327422, 0.21884219348430634, -0.024325048550963402, -0.37659570574760437, 0.2231185883283615, 0.13337597250938416, -0.2787637412548065, -0.37913426756858826, 0.14654938876628876, -0.7234607338905334, 0.05144669488072395, -0.0017997854156419635, 0.7023619413375854, 0.12853233516216278, -0.1546945422887802, 0.5140940546989441, 0.1897423267364502, 0.11037341505289078, -0.3421424925327301, -0.0028840769082307816, -0.1961231231689453, -0.0844467356801033, 0.18699763715267181, 0.23348022997379303, 0.18702775239944458, 0.3331400454044342, -0.3471583127975464, -0.23119837045669556, -0.30497339367866516, 0.38073909282684326, 0.4647885262966156, 0.4605015516281128, 0.038917556405067444, -0.20609843730926514, 0.10716313868761063, -0.49008020758628845, -0.2502357065677643, 0.16419993340969086, 0.6769198179244995, -0.4844568073749542, -0.5048296451568604, -0.10455772280693054, 0.13323500752449036, 0.4339474141597748, -0.11311723291873932, 0.47663864493370056, -0.06632941216230392, -0.26677319407463074, -0.12803564965724945, -0.024279138073325157, 0.05513312295079231, -0.1869385689496994, 0.3984564244747162, -0.19258441030979156, -0.4318213164806366, 0.36630359292030334, 0.013346727006137371, -0.1369011104106903, 0.42095187306404114, 0.5940645933151245, 0.16454429924488068, -0.6461477279663086, 0.06625260412693024, -0.07474902272224426, -0.21397989988327026, 0.03801478073000908, -0.20259766280651093, -0.30895450711250305, 0.05949966609477997, -6.169312477111816, -0.1794680953025818, -0.7661247849464417, -0.043259404599666595, -0.21736577153205872, 0.20723530650138855, 0.688549816608429, -0.09711496531963348, 0.12363510578870773, -0.304797887802124, 0.29795482754707336, 0.5493935942649841, 0.4201199412345886, 0.7136191129684448, 0.07674025744199753, 0.3675818145275116, -0.05045977234840393, -0.1404983252286911, -0.17136387526988983, -0.21833869814872742, 0.07858388125896454, -0.4668911397457123, 0.2467070370912552, 0.1494208574295044, 0.3409326374530792, 0.10669775307178497, -1.1328095197677612, 0.7366921901702881, -0.262911856174469, 0.3219693601131439, 0.2814752161502838, -0.508604109287262, -0.33289965987205505, -0.2724124491214752, 0.15105631947517395, 0.03244559466838837, 0.1661892831325531, -0.08833252638578415, 0.15872733294963837, -0.6116461753845215, -0.15302874147891998, 0.01754041761159897, -0.46158236265182495, -0.17750418186187744, -0.10416311770677567, -0.07159546762704849, 0.09678103029727936, 0.26813533902168274, -0.22210074961185455, 0.8400929570198059, 0.25448745489120483, -0.02848195843398571, 0.1063828319311142, 0.4522832930088043, -0.10482354462146759, -0.6741751432418823, 0.27467867732048035, 0.45516106486320496, -0.5444979071617126, 0.1163162887096405, 0.09327247738838196, -0.38964730501174927, 0.07452525943517685, -1.0745298862457275, -0.4646345376968384, 0.12101519107818604, -0.7028781175613403, -0.5293951034545898, 0.12864229083061218, 0.2136460393667221, 0.012940227054059505, 0.5063812732696533, 0.048616647720336914, -0.7179890871047974, -0.24763843417167664, -0.5679613351821899, 0.43878811597824097, 0.1592540740966797, 0.07197359204292297, -0.08033788949251175, 0.02367429994046688, -0.19620420038700104, 0.17528481781482697, 0.005805492866784334, -0.2143508642911911, 0.010572564788162708, 0.09706556797027588, -0.33550694584846497, -0.017844563350081444, 0.29356032609939575, 0.5468128323554993, -0.4185597896575928, 0.3025381565093994, 0.6605103015899658, -0.08304428309202194, 0.5527922511100769, 0.4301455616950989, 0.01982262171804905, 0.25841107964515686, -0.54490065574646, 0.8753195405006409, 0.3342650830745697, -0.29965487122535706, -0.6023880243301392, -0.2111164778470993, -0.5604880452156067, -1.010048747062683, -0.13190506398677826, 0.7521414756774902, -0.5157184600830078, 0.22262988984584808, -0.11838144063949585, 0.08320353925228119, -0.44120728969573975, 0.3696216642856598, 0.032864753156900406, 0.20208564400672913, -0.06112433597445488, 0.5370729565620422, -0.06078975275158882, 0.5914503335952759, 0.17908315360546112, 0.3712853491306305, 0.05919007211923599, -0.13595661520957947, -0.08461278676986694, 0.13967113196849823, 0.45839086174964905, -0.7021357417106628, 0.35225263237953186, 0.2884365916252136, 0.7053524255752563, -0.6428406834602356, 0.31327149271965027, 0.673416256904602, -0.22400154173374176, -0.8065903186798096, -0.04595095291733742, 0.4099021255970001, 0.21910902857780457, 0.5433346629142761, -0.11186875402927399, -0.16821236908435822, 0.03474615141749382, -0.10519735515117645, -0.2082132250070572, -0.5936874151229858, -0.5325607061386108, -0.05203407630324364, -0.05353207141160965, 0.39007312059402466, -0.32921743392944336, 0.09002465754747391, 0.3035774827003479, -0.5971128344535828, -0.032578207552433014, 0.4933406412601471, 0.03692083805799484, -0.0604797899723053, -0.1540311872959137, 0.34682443737983704, 0.17082779109477997, -0.8467835783958435, -0.5304253697395325, 0.0214464720338583, -0.04582659527659416, -0.21823173761367798, -0.15873025357723236, -0.31974712014198303, 0.33238041400909424, 0.1481197029352188, -0.522571325302124, -0.26807495951652527, -0.074025459587574, -0.06084859371185303, 0.41996440291404724, -0.41401365399360657, 0.317448228597641, -0.08922604471445084, 0.043182291090488434, 0.31170350313186646, -0.7317650318145752, -0.44804635643959045, 0.010358860716223717, 0.7415743470191956, 0.10447599738836288, 0.13092653453350067, -0.43232011795043945, 0.0225243978202343, 0.19911295175552368, -0.06786246597766876, -0.128108412027359, 0.33703726530075073, 0.33818456530570984, -0.4500412046909332, -0.4274042844772339, -0.04069240763783455, 0.46339768171310425, -0.32151755690574646, -0.11775299906730652, 0.30069512128829956, 0.31175699830055237, -0.004683188162744045, 0.1587892323732376, 0.5095416903495789, -0.4911763370037079, -0.24538938701152802, -0.12860214710235596, -0.18699941039085388, 0.018855663016438484, 0.12338966876268387, -0.24929480254650116, -0.19602692127227783, 0.21895329654216766, -0.4198780655860901, 0.06573899835348129, 0.36332884430885315, -0.5077661275863647, -0.49827685952186584, 0.256184458732605, 0.36573174595832825, 0.4464070796966553, -0.6021213531494141, -0.009895950555801392, -0.24377454817295074, 0.02429666928946972, 0.6091766953468323, -0.8942436575889587, -0.20560462772846222, 0.2498384416103363, -0.7481446266174316, 0.1593802124261856, 0.2849012017250061, -0.4341270625591278, -0.3831624686717987, -0.33320099115371704, -0.22541876137256622, 0.31393858790397644, 0.06887795776128769, 0.05604582279920578, -0.3328396677970886, 0.46370381116867065, 0.10908650606870651, -0.5893271565437317, 0.20931880176067352, 0.2131231427192688, 0.23265963792800903, -0.5606371164321899, -0.2912871241569519, 0.10876818746328354, -0.2736278772354126, -0.2533709704875946, -0.14181645214557648, -0.6497900485992432, 0.2685600221157074, 0.6836063861846924, -0.3758809268474579, -0.11140871047973633, 0.008148743771016598, 0.01397954486310482, -0.3492736518383026, -0.2491312325000763, -0.4288282096385956, -0.40293338894844055, 0.32546016573905945, -0.01813345029950142, -0.1617593765258789, -0.26137784123420715, -0.038719650357961655, -0.5900927186012268, -0.026890786364674568, -0.10074462741613388, 0.24135658144950867, 0.5946084260940552, 0.3386167287826538, -0.04912665858864784, -0.15291060507297516, 0.2346741408109665, 0.3187962472438812, 0.013322781771421432, -0.06681270897388458, -0.6155805587768555, 0.07306163012981415, 0.4901500344276428, 0.3397223651409149, -0.43445760011672974, 0.2167872041463852, -0.04412152245640755, -0.10068868845701218, -0.4847613275051117, 0.09922242164611816, 0.27537861466407776, -0.558296263217926, -0.07222022861242294, -0.13218969106674194, 0.2004697322845459, 0.4432435929775238, 0.4664571285247803, 0.03391043841838837, 0.12969030439853668, -0.08439796417951584, 0.41500869393348694, 0.560126006603241, -0.975997805595398, -0.025873936712741852, 0.41054674983024597, 0.42293569445610046, 0.029566163197159767, -0.19815309345722198, 0.1453808844089508, 0.48155245184898376, -0.1982567012310028, 0.13318109512329102, 0.2656804323196411, -0.6577268242835999, -0.269880473613739, -0.4645428955554962, -0.41555294394493103, 0.7451964020729065, 0.22038689255714417, 0.07045455276966095, 0.21437980234622955, 0.9608542919158936, -0.0767429769039154, -0.46225807070732117, 0.4204789102077484, -0.33781707286834717, 0.5983403921127319, -0.1607009470462799, 0.1225794106721878, 0.8515939712524414, 0.4189694821834564, -0.1071322113275528, 0.05038997530937195, -0.19440869987010956, 0.28255704045295715, -0.4385356307029724, -0.3503333032131195, -0.3363596498966217, 0.00027446827152743936, 0.8097625970840454, 0.7783295512199402, 0.36488503217697144, -0.2240987867116928, 0.23566986620426178, 0.48319390416145325, -0.20693723857402802, -0.08983399718999863, 0.2709505558013916, 0.09604264795780182, 0.4263020157814026, 0.12040087580680847, 0.11160772293806076, 0.3893543481826782, -0.23374246060848236, 0.02234729751944542, 0.08253227174282074, -0.10671035200357437, -0.2220848798751831, 0.10771501064300537, 0.12216488271951675, 0.04205769672989845, -0.539056122303009, 0.19681937992572784, -0.3008166551589966, 0.0750541090965271, 0.5193307995796204, -0.0077467914670705795, 0.12618215382099152, -0.1990126371383667, -0.2265051156282425, 0.2236318439245224, -0.6159375905990601, 0.16894283890724182, -0.14923322200775146, -0.8729931116104126, 0.20964373648166656, 0.05492329224944115, 0.1661921739578247, 0.007800128776580095, -0.24885831773281097, -0.16593977808952332, -0.14615516364574432, -0.49191343784332275, -0.2847461700439453, -0.039989739656448364, -0.08044078201055527, 0.06757421791553497, 0.3902851343154907, 0.06318319588899612, -0.18033158779144287, -0.6309051513671875, 0.29847991466522217, -0.14662642776966095, -0.09161515533924103, 0.2612762451171875, 0.06007037311792374, -0.1505434364080429, 0.4318661093711853, -0.023667586967349052, -0.4218471944332123, 0.11576887965202332, -0.06506875902414322, 0.023819781839847565, -0.40764907002449036, 0.8914306163787842, -0.4837738871574402, 0.17538942396640778, -0.20038826763629913, 0.10102128982543945, 0.1734212040901184, 0.29380279779434204, -0.2682037353515625, 0.16338033974170685, -0.15602950751781464, 0.32782354950904846, 0.5479447245597839, -0.23845049738883972, -0.2962310314178467, 0.10420804470777512, -0.5033663511276245, -0.1614956557750702, 0.12461982667446136, 0.02502669207751751, -0.19032873213291168, -0.47836819291114807, 0.001779575482942164, 0.0764475017786026, 0.35141733288764954, 0.5910886526107788, -0.12644821405410767, -0.30827903747558594, -0.5689247250556946, 0.23155689239501953, -0.37913137674331665, 0.06907393783330917, -0.18868710100650787, -0.12281603366136551, 0.1993561089038849, -0.2847561836242676, -0.1958959400653839, -0.23927606642246246, 0.06297019124031067, 0.41257745027542114, 0.09934613108634949, 0.4054819345474243, 0.4713892638683319, -0.5191683173179626, -0.550261378288269, 0.35785946249961853, 0.1251390427350998, -0.2933408319950104, -0.24488912522792816, -0.5716875195503235, -0.11366239935159683, -0.24228154122829437, 0.07308658212423325, -0.2577747702598572, 0.045540064573287964, 0.1514609307050705 ]
Clathrin has an established function in the generation of vesicles that transfer membrane and proteins around the cell. The formation of clathrin-coated vesicles occurs continuously in non-dividing cells, but is shut down during mitosis, when clathrin concentrates at the spindle apparatus. Here, we show that clathrin stabilizes fibres of the mitotic spindle to aid congression of chromosomes. Clathrin bound to the spindle directly by the amino-terminal domain of clathrin heavy chain. Depletion of clathrin heavy chain using RNA interference prolonged mitosis; kinetochore fibres were destabilized, leading to defective congression of chromosomes to the metaphase plate and persistent activation of the spindle checkpoint. Normal mitosis was rescued by clathrin triskelia but not the N-terminal domain of clathrin heavy chain, indicating that stabilization of kinetochore fibres was dependent on the unique structure of clathrin. The importance of clathrin for normal mitosis may be relevant to understanding human cancers that involve gene fusions of clathrin heavy chain.
[ -0.011593283154070377, 0.007125659845769405, -0.02273690700531006, 0.011276532895863056, 0.0077415285632014275, -0.022490251809358597, 0.011974244378507137, -0.02407054416835308, -0.012972579337656498, 0.01831560954451561, -0.012404023669660091, 0.008085799403488636, -0.015902003273367882, 0.01101966667920351, -0.004934502765536308, 0.0005602501332759857, 0.0012385776499286294, -0.007040294818580151, 0.011174224317073822, -0.023613452911376953, -0.009024766273796558, -0.02002578042447567, 0.010337275452911854, -0.000519441906362772, 0.004707615822553635, -0.010457849130034447, -0.0036061322316527367, -0.02384173311293125, -0.0203569196164608, -0.039742790162563324, -0.003387737087905407, -0.012572748586535454, -0.006222872994840145, 0.011078739538788795, 0.006862501613795757, 0.03154754266142845, -0.003940936177968979, 0.030549626797437668, 0.027002790942788124, -0.005219672806560993, -0.009385678917169571, -0.006305191665887833, 0.012407762929797173, 0.016849806532263756, -0.0071953292936086655, -0.010443715378642082, 0.00017664971528574824, 0.02865998074412346, 0.019244633615016937, -0.00003884921898134053, -0.010941440239548683, -0.006564673036336899, -0.00464915856719017, 0.014926436357200146, -0.006461001001298428, -0.016391431912779808, 0.01799781247973442, -0.033382195979356766, -0.01448227558284998, 0.019698798656463623, 0.00862343329936266, 0.029540935531258583, -0.012341064400970936, -0.010855337604880333, -0.008596694096922874, -0.06697317957878113, -0.015302050858736038, -0.01373245008289814, 0.0013484795344993472, -0.003723178757354617, 0.0006493525579571724, 0.001309314975515008, -0.01752316579222679, -0.01715835928916931, 0.0065042199566960335, -0.0018452998483553529, -0.016116151586174965, -0.000827503390610218, 0.010232528671622276, -0.007294164504855871, 0.031137777492403984, -0.01222641859203577, 0.005827971268445253, -0.002350496593862772, 0.012895980849862099, 0.021010316908359528, 0.00007857196033000946, 0.010161480866372585, 0.027163013815879822, -0.032203711569309235, 0.012413389049470425, 0.01946325972676277, 0.022388966754078865, -0.02048024907708168, 0.0007978668436408043, 0.006977081298828125, 0.031850576400756836, -0.03699846193194389, -0.0053916629403829575, -0.011333124712109566, -0.011790430173277855, 0.004518004134297371, 0.014022891409695148, -0.009988230653107166, -0.012137026526033878, 0.011258264072239399, 0.01209691260010004, 0.0016275648958981037, -0.02080298587679863, 0.012153303250670433, 0.002691175090149045, -0.004229456186294556, 0.013398244976997375, 0.020353086292743683, -0.008988572284579277, 0.014644860289990902, -0.017033811658620834, -0.00681809289380908, 0.0164458267390728, -0.0092938132584095, -0.027748247608542442, 0.014657056890428066, 0.00856907106935978, 0.007934510707855225, 0.004508949350565672, 0.008490825071930885, 0.0246039479970932, -0.013031582348048687, 0.004594123922288418, 0.022624950855970383, -0.007674654014408588, 0.011804998852312565, -0.025939559563994408, -0.013711204752326012, 0.01267088484019041, -0.004036599770188332, -0.002976115792989731, -0.025032322853803635, 0.011773934587836266, -0.0158238485455513, -0.0018179912585765123, 0.010291419923305511, 0.003597013186663389, 0.014933057129383087, -0.007742919959127903, -0.0018744493136182427, -0.030077729374170303, 0.007381278555840254, 0.00951000489294529, -0.02182115614414215, 0.000039326027035713196, 0.01919124275445938, -0.02465203031897545, -0.01535281352698803, -0.016325952485203743, 0.0022623795084655285, 0.004046985879540443, -0.038577042520046234, 0.01060892827808857, -0.011964854784309864, -0.003280266188085079, -0.010178791359066963, 0.018212497234344482, 0.009086254984140396, -0.007032747846096754, 0.00442167092114687, -0.011198179796338081, -0.012884740717709064, 0.005524630192667246, 0.0067590270191431046, -0.009161354042589664, 0.026927584782242775, 0.041660089045763016, 0.006541580893099308, 0.0038278158754110336, 0.011864869855344296, 0.011015376076102257, 0.006163776386529207, -0.020666684955358505, 0.0665118396282196, -0.015738146379590034, 0.05193270742893219, 0.044913820922374725, -0.0011613625101745129, 0.02539088763296604, -0.022931424900889397, 0.00228477967903018, -0.00693830382078886, -0.007942967116832733, -0.02714530937373638, -0.009432815946638584, -0.022594360634684563, -0.024046357721090317, 0.020513473078608513, 0.0010849700774997473, 0.004132682923227549, 0.024615271016955376, 0.00998049508780241, 0.005836923606693745, 0.03350408002734184, -0.002876720856875181, 0.0005501555278897285, 0.032806675881147385, -0.0035944166593253613, 0.0450749471783638, -0.0026786867529153824, -0.005669123493134975, 0.030163034796714783, -0.021583206951618195, -0.009289511479437351, 0.021660299971699715, -0.00334474490955472, -0.021873679012060165, -0.00978068821132183, 0.004254734143614769, 0.013546604663133621, -0.0032291309908032417, -0.01204526424407959, 0.0008491869084537029, -0.012858865782618523, 0.002052705967798829, 0.0012633823789656162, 0.015651067718863487, -0.003689844161272049, 0.018338114023208618, 0.019500944763422012, -0.013107850216329098, 0.015497220680117607, 0.003510694485157728, 0.008770875632762909, 0.004350929521024227, -0.032072823494672775, -0.012965384870767593, 0.033454492688179016, 0.002542458940297365, -0.010622157715260983, 0.010532756336033344, 0.01098380982875824, 0.0222599059343338, -0.002926920773461461, -0.013533512130379677, -0.017400767654180527, 0.025982625782489777, -0.0059964945539832115, 0.00836935080587864, -0.01495052594691515, -0.014644831418991089, -0.019332392141222954, 0.013333357870578766, -0.03834882378578186, 0.009362577460706234, 0.004677392542362213, -0.02038603276014328, 0.01859600469470024, -0.049179065972566605, 0.0021597843151539564, 0.03756614401936531, 0.01279490441083908, 0.026682797819375992, 0.010653333738446236, 0.005050721578299999, 0.005680982489138842, -0.005916961468756199, 0.002338775433599949, -0.019573207944631577, 0.013444137759506702, 0.010232092812657356, 0.012861302122473717, 0.004906608723104, 0.0033555948175489902, 0.010514985769987106, -0.0002909908362198621, 0.0007230811752378941, -0.08182729780673981, -0.012752766720950603, 0.004450087435543537, 0.006781957112252712, 0.0037597722839564085, -0.039256609976291656, 0.004846511408686638, -0.002723699202761054, 0.0018393374048173428, 0.015754081308841705, 0.005644978955388069, 0.021312706172466278, -0.005519896745681763, -0.021425984799861908, 0.019100822508335114, -0.014235548675060272, 0.012227796949446201, -0.020779931917786598, -0.008378013968467712, 0.006339822895824909, -0.007624328602105379, -0.02386607602238655, -0.024436160922050476, 0.012784995138645172, 0.009418930858373642, -0.014063909649848938, -0.008317163214087486, -0.014641441404819489, -0.0023888484574854374, 0.017172349616885185, -0.004530204460024834, 0.00010467297397553921, -0.003687662770971656, 0.013133994303643703, 0.015030015259981155, 0.003142271190881729, -0.003591182641685009, -0.007283792365342379, -0.0037915136199444532, 0.007733883336186409, -0.01670893095433712, 0.013104320503771305, -0.012816635891795158, 0.020096708089113235, 0.007269334513694048, -0.011353498324751854, 0.01698990724980831, -0.010301964357495308, 0.018670713528990746, -0.010313957929611206, 0.00476855831220746, 0.011496451683342457, 0.01703130453824997, 0.02201654389500618, -0.0040548937395215034, -0.01280415989458561, 0.024451155215501785, 0.004313851241022348, -0.013942568562924862, -0.007795651908963919, -0.007194731384515762, -0.023613151162862778, -0.0029354002326726913, 0.003072874853387475, 0.005051181651651859, 0.0215175598859787, 0.016580678522586823, 0.006631635129451752, -0.028574828058481216, -0.0020837956108152866, 0.010074790567159653, -0.01511275116354227, 0.005750735756009817, -0.009952284395694733, -0.0319281667470932, -0.009953976608812809, -0.006924674846231937, -0.0054830219596624374, 0.007081519812345505, -0.03887086734175682, 0.006330939009785652, 0.0027059216517955065, -0.013888750225305557, 0.016917400062084198, -0.02016942948102951, -0.04758498817682266, 0.015025973320007324, 0.02381887659430504, 0.012618334032595158, -0.02146308869123459, -0.0013615288771688938, -0.007559388875961304, -0.010963041335344315, 0.009676397778093815, 0.0026500248350203037, -0.006764920894056559, 0.02811584435403347, 0.018629299476742744, -0.004267141222953796, 0.007803763262927532, -0.02559293620288372, 0.010827179998159409, -0.014496102929115295, -0.003051990643143654, -0.024374790489673615, 0.01552063412964344, -0.0018489420181140304, -0.010826241225004196, 0.012618476524949074, -0.004682404920458794, 0.005092191509902477, 0.00939866155385971, -0.010680251754820347, 0.02028491348028183, 0.015885168686509132, 0.01815478689968586, -0.008798349648714066, -0.00729287089779973, 0.07172694802284241, 0.020024852827191353, -0.005415860563516617, -0.017193134874105453, 0.015985026955604553, -0.01420579757541418, -0.02244654670357704, -0.0008074603974819183, -0.0312400721013546, 0.002794999862089753, 0.01416837703436613, -0.028971869498491287, -0.009770473465323448, -0.014234890230000019, -0.027400003746151924, -0.017255663871765137, -0.027825716882944107, 0.009018593467772007, 0.021264858543872833, -0.008762177079916, 0.01965118944644928, -0.02584618702530861, -0.008166413754224777, -0.02607814595103264, -0.017885074019432068, -0.0020472039468586445, 0.006025474518537521, -0.016986273229122162, -0.027812987565994263, 0.009199418127536774, 0.02537614107131958, -0.03510498255491257, -0.005891470704227686, 0.02441375143826008, 0.006603676360100508, -0.007445172406733036, -0.021286068484187126, -0.03183005005121231, -0.011186705902218819, -0.016103470697999, 0.02346462570130825, -0.014483827166259289, -0.022125091403722763, 0.017664114013314247, 0.006978949531912804, 0.0022944631054997444, 0.005247787106782198, -0.009764792397618294, 0.018571894615888596, -0.01979738101363182, -0.018859703093767166, 0.003345540026202798, 0.01534770056605339, -0.009350964799523354, 0.011376896873116493, -0.027260567992925644, -0.00009019207209348679, -0.01015625149011612, -0.03856512904167175, 0.0018785527208819985, 0.003661166410893202, 0.011413953267037868, 0.011054222472012043, -0.018603799864649773, -0.011325429193675518, -0.015837475657463074, -0.0013081012293696404, -0.004493750166147947, -0.025303054600954056, -0.012022577226161957, 0.0011744614457711577, -0.02970591001212597, -0.026894044131040573, -0.012193413451313972, -0.011174079962074757, -0.020573284476995468, 0.014517417177557945, -0.01404787041246891, 0.023539584130048752, -0.014321604743599892, 0.014263570308685303, 0.0037223096005618572, -0.004827397875487804, 0.0043650297448039055, -0.0016530317952856421, 0.0019862139597535133, -0.018476366996765137, -0.07507900893688202, -0.016670003533363342, -0.016162171959877014, -0.007019064389169216, 0.0015766152646392584, -0.006655531004071236, -0.01645589806139469, 0.021404342725872993, -0.0019466523081064224, -0.009496070444583893, 0.019235022366046906, 0.003284132108092308, 0.0059791854582726955, 0.0013129247818142176, 0.011065036058425903, -0.016415182501077652, -0.030860215425491333, 0.025343308225274086, -0.02207981050014496, -0.039286281913518906, -0.01990707404911518, 0.007783610839396715, -0.015598103404045105, -0.01318642683327198, 0.006735350005328655, -0.08056215196847916, 0.017499877139925957, -0.005895210895687342, 0.009941505268216133, 0.0023752646520733833, -0.004776843823492527, -0.014590884558856487, -0.0036662407219409943, -0.025809183716773987, -0.017682721838355064, 0.03367238491773605, 0.007437399588525295, -0.0010667131282389164, -0.03841271996498108, -0.008215557783842087, -0.004478992894291878, 0.014510877430438995, 0.008100837469100952, 0.021466968581080437, 0.026948638260364532, 0.012085271999239922, -0.016236010938882828, -0.01708739437162876, 0.004710963927209377, -0.008868076838552952, -0.00569596141576767, -0.017015378922224045, 0.012933474965393543, -0.01317255012691021, 0.0019668196327984333, -0.014134611934423447, -0.017502734437584877, -0.007727000862360001, -0.011810422874987125, -0.013176465407013893, -0.014773508533835411, 0.009464696049690247, 0.007867320440709591, -0.012107831425964832, -0.024918215349316597, -0.007595684379339218, 0.02389984019100666, -0.0017423008102923632, 0.00930470135062933, 0.003357009496539831, 0.018131211400032043, 0.005684207659214735, -0.004085351713001728, 0.0020556289236992598, -0.013915875926613808, 0.01326821744441986, -0.0024819648824632168, -0.016495877876877785, -0.00035426998510956764, 0.009988768957555294, -0.0027407407760620117, 0.0023333297576755285, 0.013355189934372902, 0.026967355981469154, -0.0009816428646445274, 0.00044009037083014846, 0.003830870846286416, -0.0012018687557429075, 0.07136659324169159, -0.021053504198789597, 0.00841950811445713, -0.007161903195083141, 0.006475614383816719, 0.007342650089412928, -0.019112184643745422, -0.020557690411806107, 0.00398220494389534, -0.045274004340171814, -0.0011734248837456107, -0.012662569060921669, 0.012929786927998066, 0.013016932643949986, -0.005581175442785025, 0.013039110228419304, 0.00868222676217556, -0.001068793353624642, -0.030106298625469208, 0.03249872475862503, -0.01628362573683262, 0.007296477444469929, 0.011138709262013435, -0.01020035520195961, -0.023749427869915962, 0.006306653376668692, 0.014551503583788872, 0.019850686192512512, 0.010839307680726051, 0.007025272585451603, -0.0006363586289808154, -0.015264077112078667, 0.0063774846494197845, -0.000665958970785141, 0.010798787698149681, 0.016155455261468887, 0.0015637404285371304, 0.0021617859601974487, -0.014016360975801945, -0.01139090582728386, 0.005258130840957165, 0.0007279020501300693, 0.0027704723179340363, -0.009413499385118484, 0.007769571151584387, -0.01433517225086689, 0.009290067479014397, 0.014118853025138378, -0.005398967303335667, -0.0002011291217058897, 0.03532285988330841, 0.006546528544276953, 0.0033321946393698454, -0.019793875515460968, 0.020885108038783073, -0.002525405492633581, -0.014368057250976562, 0.014107119292020798, -0.0009929100051522255, -0.006311680190265179, 0.0074431863613426685, -0.0065885912626981735, -0.012618615292012691, -0.01766156032681465, -0.011136244982481003, -0.0040776170790195465, 0.013245940208435059, -0.013980712741613388, 0.01441830676048994, 0.015952229499816895, 0.0008733163122087717, 0.019981451332569122, 0.006150879897177219, -0.0055029429495334625, -0.004299020394682884, 0.02474842220544815, 0.009695879183709621, -0.05174238607287407, 0.012991408817470074, 0.007011497393250465, -0.0026880656369030476, 0.029220351949334145, 0.01293981447815895, 0.004857183899730444, -0.02762736566364765, -0.006800775416195393, -0.009278657846152782, 0.011388640850782394, 0.0006052003591321409, 0.010827723890542984, 0.015158755704760551, -0.0046974048018455505, 0.013247862458229065, 0.024130549281835556, 0.0028383396565914154, 0.0355706587433815, 0.01191367581486702, 0.0047574592754244804, 0.007466805167496204, 0.009848424233496189, -0.0019843867048621178, 0.012716141529381275, -0.0007790578529238701, 0.001792458351701498, -0.029588082805275917, -0.030430004000663757, -0.0038530121091753244, 0.03181440010666847, -0.007361527532339096, 0.03401469439268112, 0.004841777961701155, 0.006464598700404167, 0.017637155950069427, -0.01304219663143158, -0.008801931515336037, 0.02809729240834713, -0.024986926466226578, -0.0015106117352843285, -0.017164990305900574, -0.011996941640973091, 0.020163100212812424, 0.00552195543423295, -0.02474190481007099, 0.021721020340919495, -0.025990799069404602, -0.027482623234391212, -0.003528257831931114, 0.022929051890969276, 0.014181718230247498, -0.03759593516588211, 0.015432287007570267, 0.0025068752001971006, -0.011820849031209946, 0.01818949542939663, 0.014504404738545418, 0.00482011865824461, -0.019713453948497772, -0.0077789849601686, -0.0011150417849421501, -0.023498786613345146, 0.01495502982288599, -0.027199288830161095, 0.0014988486655056477, 0.023871779441833496, 0.008137239143252373, -0.020411577075719833, 0.0026893392205238342, 0.01890462264418602, 0.010865721851587296, 0.005441106390208006, 0.010438511148095131, 0.01067846268415451, -0.008771950379014015, -0.010856034234166145, 0.016040287911891937, 0.020301751792430878, 0.01951206848025322, -0.02530072070658207, -0.020127825438976288, 0.003779867198318243, -0.00333950063213706, -0.011486444622278214, 0.022161507979035378, 0.014818193390965462, 0.005568832159042358, -0.009982248768210411, -0.02843439020216465, -0.031287722289562225, 0.010703103616833687, -0.00009975209832191467, -0.011719632893800735, 0.0021037389524281025, -0.01543554849922657, 0.002556299092248082, -0.00045618508011102676, -0.013532864861190319, -0.019082309678196907, -0.004983946681022644, 0.012680805288255215, 0.0016139703802764416, -0.007461641449481249, -0.02063104510307312, 0.023876488208770752, -0.001029870705679059, 0.010320845991373062, -0.013533294200897217, -0.004270731471478939, -0.012620293535292149, -0.01189441978931427, 0.005813911557197571, -0.002135062823072076, 0.011362919583916664, 0.0007513922173529863, 0.022325608879327774, -0.016430601477622986, 0.012883896008133888, 0.015856344252824783, -0.0031274640932679176, 0.003965417388826609, -0.0005052087362855673, 0.009417829103767872, 0.0031619262881577015 ]
[ -0.05908709391951561, 0.0333767868578434, 1.169381022453308, 0.21607273817062378, 0.06970122456550598, -0.39537516236305237, -0.23276850581169128, -0.010765771381556988, -0.17381782829761505, -0.2722766101360321, 0.18395289778709412, -0.20849965512752533, -0.5380856990814209, 0.4689887464046478, 0.21498970687389374, 0.024395208805799484, 0.24902480840682983, 0.548802375793457, 0.033740557730197906, -0.6693899631500244, -0.22093068063259125, -0.2964048981666565, 0.348143070936203, -0.033652037382125854, 0.6003832221031189, -0.4943258762359619, 0.2353704273700714, 0.06145467981696129, 0.4735201895236969, -0.26157575845718384, -0.24720054864883423, 0.0561833418905735, 0.004179251380264759, 0.1862701177597046, -0.041956815868616104, -0.13232295215129852, -0.1898142695426941, 0.014489836990833282, 0.40071260929107666, -0.27774494886398315, -0.3735889792442322, -0.04608629643917084, 0.15908019244670868, 0.043771110475063324, -0.4193691909313202, 0.046297576278448105, -1.0571568012237549, 1.1187465190887451, -0.21478839218616486, 0.03778580203652382, -0.7443636655807495, 0.017739107832312584, 0.6199220418930054, -0.06756235659122467, 0.1776091754436493, 0.09519919008016586, -0.6307229399681091, 0.196891188621521, 0.3695588707923889, -0.7574330568313599, 0.038419608026742935, 0.03613034635782242, 0.15577730536460876, 0.22943322360515594, 0.5295740962028503, 0.4163064658641815, 0.05361128970980644, -0.6839593052864075, -0.5673960447311401, -0.30037668347358704, 0.132862851023674, -0.2767259180545807, -0.06712093204259872, 0.3441601097583771, 0.2954951226711273, -0.05198805034160614, -0.745922863483429, -0.09270092099905014, 0.2575339376926422, 0.29274359345436096, -0.2970462739467621, 0.6262416839599609, 0.19746583700180054, -0.023230480030179024, 0.653771162033081, 0.21100343763828278, -0.5796093940734863, 0.7727805972099304, -0.710870623588562, -0.2208394706249237, 0.036950044333934784, 0.21718105673789978, -0.03940736502408981, 0.20457299053668976, -0.09294986724853516, -0.29722219705581665, 0.21517539024353027, -0.15840017795562744, -0.059206314384937286, 0.47059518098831177, -0.1044972613453865, -0.26672402024269104, -0.07550431042909622, -0.8502574563026428, -0.34697651863098145, 0.17983250319957733, -0.10899273306131363, -0.37801113724708557, 0.05390176549553871, 0.266043096780777, -0.42231619358062744, -0.23296447098255157, -0.26240217685699463, -0.09550001472234726, -0.04256824776530266, -0.34053775668144226, -0.22321759164333344, -0.17756640911102295, 0.17824262380599976, 0.4701792001724243, -0.6184256076812744, 1.0058730840682983, -0.004086664877831936, -0.11949079483747482, -0.24757421016693115, -0.09949477761983871, -0.3793987035751343, 0.28999650478363037, -0.6642745137214661, 0.5831077694892883, 0.49112609028816223, 0.9331525564193726, -0.23548832535743713, 0.27006447315216064, -0.26007071137428284, -0.08476447314023972, 0.08157909661531448, 0.2625434994697571, 0.44951167702674866, 0.09494173526763916, -0.3679555654525757, -0.18500395119190216, -0.17163637280464172, 0.021222326904535294, -0.2724139094352722, -0.5695391893386841, -0.4440382719039917, -0.2147335410118103, -0.18075451254844666, -0.1486808806657791, 0.08083681762218475, 0.1963397115468979, -0.22777806222438812, -0.1710335910320282, -0.20287571847438812, -0.07879405468702316, 0.14009201526641846, 0.12641599774360657, 0.09755387157201767, 0.09186907857656479, -0.11508335918188095, 0.05394751578569412, -0.4680033326148987, 0.15477041900157928, 0.11796271800994873, -0.1116405725479126, 0.3886988162994385, 0.7138304710388184, 0.1252099722623825, 0.16387741267681122, 0.2798738479614258, -0.06005987524986267, 0.37229153513908386, -0.5809865593910217, -0.3555217385292053, 0.011573497205972672, 0.044653259217739105, -0.20712950825691223, -0.21848639845848083, -0.32129597663879395, -0.6666676998138428, 0.19451089203357697, -0.5268839597702026, -0.2595311999320984, -0.2182232290506363, 0.45132118463516235, 0.4656238853931427, -0.14395256340503693, -0.4618319869041443, -0.2532675862312317, 0.02427811175584793, -0.007029409985989332, -0.028218679130077362, -0.5299444198608398, 1.7148988246917725, -0.2235524207353592, -0.3293263614177704, 1.1889532804489136, 0.11919727921485901, -0.17432436347007751, -0.6634006500244141, 0.2274625301361084, 0.5022277235984802, -0.6559514403343201, -0.0936875194311142, 0.7686653733253479, 0.1393347978591919, 0.0036484245210886, 0.5952107906341553, 0.12775157392024994, 0.39403247833251953, -0.00807979330420494, 0.11565946042537689, -0.02719021402299404, 0.22398030757904053, -0.8703097105026245, -0.1581260710954666, -0.022419515997171402, -0.1326734721660614, 0.38472095131874084, 0.2960011661052704, -0.37772136926651, 0.5528889298439026, 1.0354079008102417, -0.36217066645622253, 0.4921700358390808, 0.7707085609436035, 0.13763336837291718, 0.5160320997238159, 0.2124001681804657, 0.4095904231071472, -1.1094214916229248, 0.13915041089057922, -0.281027615070343, -0.30279427766799927, 0.05486954376101494, 0.4846649467945099, 0.22576084733009338, -0.24066799879074097, -0.05107242986559868, -0.052008386701345444, 0.3949502110481262, -0.841741681098938, -0.20756369829177856, 0.1156855970621109, -0.16348037123680115, -0.04197541996836662, 0.11672700196504593, -0.7386128902435303, -0.257996529340744, 0.03521997854113579, 0.6086834669113159, -0.04412803426384926, -0.32155901193618774, 0.5662218332290649, -0.19412226974964142, -0.3697202205657959, 0.20562298595905304, 0.4468415379524231, 0.21599645912647247, -0.15162378549575806, -0.1819041669368744, -0.22018684446811676, 0.18248340487480164, -0.37360528111457825, 0.03966078534722328, -0.4091253876686096, -0.640458881855011, 1.185861349105835, 0.9387305974960327, 0.7290977835655212, 0.0016025890363380313, -0.6933508515357971, -0.03486006706953049, -0.25545886158943176, -0.32971030473709106, -0.003595608053728938, 0.22230461239814758, -0.07450041174888611, -0.5459600687026978, -0.374662309885025, 0.22537408769130707, 0.5573338866233826, -0.09748774766921997, -0.44472941756248474, -0.05789393186569214, 0.17369647324085236, -0.0022444785572588444, 0.17469607293605804, -0.5806522965431213, -0.1554688811302185, 0.34080761671066284, -0.41886112093925476, 0.011673890985548496, 0.2547660768032074, 0.6846891045570374, 0.3707759976387024, 0.17196880280971527, 0.6395003199577332, -0.24662138521671295, -0.0774635374546051, 0.05066392570734024, -0.2691550552845001, -0.00467093987390399, 0.1497173309326172, 0.08796092867851257, 0.016832971945405006, -0.13575968146324158, -5.9041876792907715, 0.4132455289363861, -0.20390695333480835, -0.18992705643177032, 0.8234722018241882, -0.15230217576026917, 1.043190598487854, 0.10942672193050385, 0.16693967580795288, -0.0039895884692668915, -0.16682937741279602, 0.44607430696487427, -0.5008533000946045, -0.02854558825492859, 0.015959640964865685, 0.02021133154630661, 0.20551280677318573, 0.06743782013654709, 0.24821068346500397, -0.038018688559532166, -0.1718152016401291, -0.027975324541330338, 0.3209996819496155, 0.5396740436553955, -0.10120918601751328, -0.2268523871898651, -0.6215552091598511, 0.03447246551513672, -0.32293573021888733, 0.1479295790195465, -0.5758926868438721, -0.608207643032074, 0.3504401743412018, -0.8315810561180115, 0.33279529213905334, -0.03265933692455292, -0.017290879040956497, -0.01023013424128294, 0.0381598025560379, -0.20216713845729828, 0.49042272567749023, 0.47722434997558594, -0.1745588630437851, -0.448451966047287, 0.29508399963378906, -0.3057417869567871, -0.26942557096481323, -0.198517844080925, -0.5989030003547668, 1.0438684225082397, -0.22148102521896362, -0.2919257879257202, 0.4832428991794586, -0.14751866459846497, 0.6652502417564392, 0.12582425773143768, -0.19929945468902588, -0.3513886630535126, -0.6711683869361877, -0.11367920786142349, -0.10865447670221329, -0.17327329516410828, -0.46773627400398254, -0.20266319811344147, -0.007583909202367067, 0.11034200340509415, -1.0624428987503052, -0.03379686549305916, 0.5813025236129761, -0.2584826648235321, -0.31267815828323364, -0.048737797886133194, 0.0627162978053093, -0.5696796178817749, 0.3059164881706238, -0.3589223027229309, -0.0933191254734993, -0.33644360303878784, 0.06823662668466568, 0.29330673813819885, -0.26189109683036804, 0.09972221404314041, -0.15723058581352234, 0.000841537257656455, 0.06688551604747772, -0.7350021600723267, -0.5618460774421692, -0.48739054799079895, -0.3239229917526245, 0.21989649534225464, 0.38707366585731506, -0.2624627947807312, 0.253480464220047, -0.06664066761732101, -0.02453344315290451, -0.013845943845808506, -0.026763705536723137, 0.5477614402770996, 0.1701086461544037, -0.29682669043540955, 1.340912103652954, 0.247421532869339, -0.38777679204940796, -0.546505331993103, -0.145799919962883, 0.04904678836464882, -0.7610945701599121, 0.6675387620925903, 0.08425507694482803, -0.13635031878948212, -0.6934214234352112, 0.2446202039718628, -0.3681517243385315, -0.8617317080497742, 0.5038390755653381, 0.03229064121842384, -0.5149299502372742, -0.04246608912944794, 0.5806304812431335, -0.5691971182823181, 0.10043397545814514, 0.33977365493774414, -0.04663820192217827, 0.05919031798839569, -0.49324071407318115, 0.12981237471103668, 0.39248037338256836, 0.4027034640312195, -0.04841996729373932, -0.24601884186267853, 0.33521386981010437, 0.17415249347686768, -0.19930575788021088, -0.6208851933479309, -0.013657891191542149, -0.3881891965866089, -0.19071045517921448, 0.38325777649879456, 0.06801724433898926, -0.7610223293304443, 0.45670291781425476, -0.35880348086357117, -0.028799250721931458, -0.11561600863933563, -0.007337911520153284, 0.2914208471775055, -0.02868049032986164, 0.5937637686729431, -0.3841915428638458, 0.05976756662130356, 0.17550642788410187, -0.23998358845710754, 0.18689967691898346, 0.3021091818809509, -0.26271289587020874, -0.07079494744539261, 0.5183731913566589, 0.28715676069259644, 0.8028873205184937, -0.6545799374580383, -0.2664636969566345, 0.4528977870941162, -0.6090242266654968, 0.5071977972984314, -0.25390809774398804, -0.18254536390304565, -0.12083039432764053, -0.10019930452108383, -0.19723539054393768, -0.11660853028297424, -0.48848050832748413, -0.04844367131590843, -0.3660023808479309, 0.015294908545911312, 0.009644169360399246, 0.06240101158618927, -0.22629472613334656, -0.032045792788267136, 0.10964304953813553, -0.19438347220420837, -0.20860585570335388, -0.548469603061676, 0.04023854434490204, -0.05525008589029312, 0.08340892195701599, 0.06461861729621887, 0.21257071197032928, -0.21361573040485382, -0.1569512039422989, -0.06899267435073853, 0.41772064566612244, 0.14537157118320465, 0.2775973379611969, -0.36814582347869873, 0.0685562863945961, 0.28065773844718933, -0.2564249038696289, 1.1179194450378418, -0.30947622656822205, -0.4705621898174286, 0.1396740972995758, 0.08421768993139267, -0.4801776707172394, 0.2916564345359802, 0.4324902594089508, 0.10533131659030914, -0.4189753234386444, 0.05990540236234665, 0.07245082408189774, -0.042861342430114746, 0.002106825355440378, -0.45910000801086426, 0.4018295705318451, 0.10975038260221481, 0.07373059540987015, 0.04864059388637543, 0.32211360335350037, -0.11435607820749283, -0.24958330392837524, 0.354727566242218, 0.11424479633569717, 0.18644143640995026, 0.012621894478797913, -0.25251132249832153, -0.199366495013237, 0.23184245824813843, 0.2282218635082245, -0.5690719485282898, 0.3801097273826599, 0.2295065075159073, 0.15012946724891663, -0.4110199809074402, 0.29886674880981445, 0.032652027904987335, -0.4337814450263977, -0.11826664209365845, -0.03676250949501991, 0.31214702129364014, -0.1792714148759842, 0.4116213619709015, 0.6121412515640259, 0.3136734068393707, -0.45607948303222656, 0.1701667308807373, -0.3593209683895111, 0.7701940536499023, 0.18569940328598022, -0.5957645177841187, -0.24957360327243805, 0.11290191859006882, 0.331426739692688, 0.09011651575565338, 0.282678484916687, 0.29430967569351196, 0.7932592630386353, 0.4706480801105499, 0.056041210889816284, -0.14029768109321594, 0.18139472603797913, -0.00028513846336863935, -0.47683286666870117, 0.2803132236003876, -0.15742884576320648, 0.15469561517238617, 0.35169747471809387, 0.005672574508935213, -0.33098113536834717, -0.48366981744766235, 0.7292398810386658, 0.19604980945587158, -0.08740370720624924, 0.18847447633743286, 0.7188088297843933, 0.16864053905010223, -0.1789272427558899, 0.5759547352790833, -0.26900237798690796, 0.10341175645589828, -0.345541775226593, 0.10185679793357849, -0.7270514369010925, -0.5037156343460083, 0.541923463344574, -0.18956954777240753, 0.3735906779766083, -0.6849548816680908, -0.27707159519195557, -0.06955733895301819, 0.22837649285793304, -0.23919245600700378, -0.1113753467798233, 0.0012021355796605349, -0.2965230345726013, -0.5683320760726929, 0.12098909169435501, 0.29016566276550293, -0.36922430992126465, 0.45329153537750244, -0.18774528801441193, 0.19937056303024292, -0.7446257472038269, 0.3206355571746826, 0.3207074999809265, -1.1383193731307983, -0.18745195865631104, 0.24437476694583893, 0.33794936537742615, 0.18842445313930511, -0.8582834005355835, 0.26853832602500916, 0.06821820139884949, -0.031922370195388794, -0.1343041956424713, -0.31013554334640503, -0.28539663553237915, -0.017355311661958694, 0.22578361630439758, -0.20283451676368713, 0.0596468523144722, 0.3327159881591797, 0.3936425447463989, 0.4726110100746155, -0.0704815685749054, 0.1297396719455719, -0.4923528730869293, 0.33108416199684143, 0.4436444640159607, -0.02406931295990944, -0.2716295123100281, 0.4248534142971039, 0.7431421875953674, -0.02724882774055004, -0.2030061036348343, 0.20744822919368744, 0.23014973104000092, 0.25835731625556946, -0.31689390540122986, -0.3430037498474121, 0.17088496685028076, 0.5159015655517578, 0.3383927345275879, 0.8264756202697754, -0.5654085874557495, -0.23740367591381073, 0.44892144203186035, 0.1419118344783783, 0.029131794348359108, -0.20470570027828217, -0.03184489905834198, 0.6995118856430054, 0.941459059715271, -0.4553624093532562, -0.1341482549905777, 0.014170581474900246, -0.7223067879676819, 0.07613548636436462, 0.6476325392723083, -0.26190680265426636, -0.4591957926750183, -0.15784549713134766, -0.7823007106781006, 0.5514777898788452, -0.25730252265930176, 0.6811062097549438, 0.09506570547819138, -0.13157974183559418, 0.5816656351089478, -0.48078057169914246, 0.30986642837524414, -0.18190892040729523, -0.04792637750506401, 0.15917956829071045, -0.3143414855003357, -0.18069833517074585, -0.21876110136508942, -0.7991235256195068, 0.2575739026069641, 0.16113974153995514, 0.06092708557844162, 0.31090500950813293, -0.274331659078598, 0.009237493388354778, -0.05082870274782181, -0.4281986951828003, -0.44902294874191284, -0.1628885418176651, 0.16274459660053253, -0.5247015953063965, -0.2838219404220581, 0.2533385455608368, 0.17368002235889435, -0.725117027759552, 0.12326560169458389, -0.19252008199691772, 0.15226061642169952, 0.2831030488014221, -0.0013398438459262252, 0.3186991214752197, 0.3197743594646454, 0.09321863204240799, -0.1963118463754654, 0.5119137167930603, -0.08640563488006592, 0.13525310158729553, -0.18547873198986053, 0.7117801904678345, -0.4687114953994751, 0.12442959100008011, -0.5656399130821228, 0.002465955214574933, 0.9980589151382446, 0.6500024795532227, -0.011264893226325512, 0.03283824026584625, 0.4545884430408478, 0.3550901710987091, -0.07316192984580994, -0.30862146615982056, -0.24515880644321442, -0.2186320275068283, 0.03114517591893673, -0.16879427433013916, 0.5712645053863525, 0.08717288821935654, 0.0038023116067051888, -0.09397079050540924, 0.3573092222213745, 0.6166803240776062, -0.3964841365814209, -0.008223533630371094, -0.06779862940311432, -0.22468604147434235, -0.28172940015792847, 0.5618141293525696, -0.19226373732089996, 0.7788776159286499, -0.7621933817863464, -0.12634098529815674, -0.10278426110744476, -0.1973230242729187, 0.12466444075107574, 0.6012410521507263, 0.40384697914123535, -0.06200403720140457, 0.32896286249160767, -0.07926545292139053, 0.014426365494728088, -0.6118053197860718, -0.9104616045951843, -0.16340461373329163, 0.05451145023107529, -0.4889894723892212, -0.2634070813655853, 0.2834586799144745, 0.3349625766277313, 0.018573107197880745, -0.25101137161254883, -0.052118200808763504, -0.5026386380195618, 0.4877241253852844 ]
Basal extracellular glutamate sampled in vivo is present in micromolar concentrations in the extracellular space outside the synaptic cleft, and neither the origin nor the function of this glutamate is known. This report reveals that blockade of glutamate release from the cystine-glutamate antiporter produced a significant decrease (60%) in extrasynaptic glutamate levels in the rat striatum, whereas blockade of voltage-dependent Na+ and Ca2+ channels produced relatively minimal changes (0-30%). This indicates that the primary origin of in vivo extrasynaptic glutamate in the striatum arises from nonvesicular glutamate release by the cystine-glutamate antiporter. By measuring [35S]cystine uptake, it was shown that similar to vesicular release, the activity of the cystine-glutamate antiporter is negatively regulated by group II metabotropic glutamate receptors (mGluR2/3) via a cAMP-dependent protein kinase mechanism. Extracellular glutamate derived from the antiporter was shown to regulate extracellular levels of glutamate and dopamine. Infusion of the mGluR2/3 antagonist (RS)-1-amino-5-phosphonoindan-1-carboxylic acid (APICA) increased extracellular glutamate levels, and previous blockade of the antiporter prevented the APICA-induced rise in extracellular glutamate. This suggests that glutamate released from the antiporter is a source of endogenous tone on mGluR2/3. Blockade of the antiporter also produced an increase in extracellular dopamine that was reversed by infusing the mGluR2/3 agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxlylate, indicating that antiporter-derived glutamate can modulate dopamine transmission via mGluR2/3 heteroreceptors. These results suggest that nonvesicular release from the cystine-glutamate antiporter is the primary source of in vivo extracellular glutamate and that this glutamate can modulate both glutamate and dopamine transmission.
[ -0.0036416607908904552, 0.014542929828166962, -0.0041869874112308025, 0.024233877658843994, 0.015309161506593227, -0.01631437987089157, 0.010155683383345604, -0.008806326426565647, -0.013809503987431526, -0.020805826410651207, -0.009818361140787601, 0.008836694993078709, -0.011389359831809998, 0.020240791141986847, -0.023738756775856018, 0.011190113611519337, -0.006370346527546644, -0.01481008529663086, 0.005319671705365181, 0.021923882886767387, 0.0068603442050516605, -0.018450096249580383, 0.010219891555607319, -0.04024365916848183, 0.002017349237576127, -0.0047942232340574265, 0.016514208167791367, -0.009791259653866291, 0.0004950991133227944, 0.0069894976913928986, -0.01746327057480812, -0.011818613857030869, -0.0011118613183498383, -0.014886163175106049, -0.012067136354744434, 0.01083600614219904, -0.007888630032539368, 0.03280404210090637, 0.013791926205158234, -0.003948775120079517, 0.01655007340013981, -0.011433285661041737, 0.010635981336236, -0.008272415027022362, -0.008603525348007679, 0.008607965894043446, -0.005143486894667149, 0.009337566792964935, -0.0043455613777041435, -0.002208863850682974, 0.0020305272191762924, -0.025927912443876266, -0.01077792327851057, 0.0037015979178249836, -0.006561503745615482, -0.0017880231607705355, 0.01736553944647312, -0.01122019998729229, -0.004410469904541969, -0.0392766073346138, -0.006259247660636902, 0.0428779199719429, 0.0008923164568841457, 0.0055412352085113525, 0.0068405866622924805, -0.06672226637601852, 0.0213782899081707, -0.017076222226023674, 0.006619527470320463, 0.006467881146818399, -0.0022530723363161087, 0.011026130989193916, -0.008241851814091206, -0.0034561296924948692, 0.007736873812973499, 0.012326525524258614, -0.010452618822455406, 0.011839035898447037, -0.0080367811024189, 0.013086396269500256, -0.011358082294464111, -0.016596734523773193, -0.015264617279171944, 0.009511323645710945, -0.016682259738445282, -0.009192099794745445, -0.009127073921263218, 0.001306657213717699, 0.010130207985639572, -0.01734476536512375, 0.014110887423157692, 0.0007352870889008045, -0.002341192215681076, 0.025305941700935364, 0.00015886826440691948, 0.003380079520866275, -0.013072824105620384, 0.0068678101524710655, 0.009139548987150192, -0.010590238496661186, -0.005650519859045744, 0.002549179829657078, 0.01776326447725296, 0.02321998029947281, -0.00460652494803071, 0.00783924013376236, -0.007056223228573799, -0.0268932543694973, -0.0063070920296013355, 0.0050755091942846775, 0.0027741328813135624, 0.007459879387170076, 0.01205199770629406, -0.0006487743812613189, 0.013954619877040386, 0.011948483064770699, -0.001045619952492416, -0.018247012048959732, 0.0015741686802357435, -0.023729931563138962, 0.031338829547166824, -0.006723179016262293, 0.002158730523660779, -0.0038181378040462732, 0.005748461000621319, -0.015695471316576004, 0.00816667266190052, -0.021939825266599655, 0.0021488156635314226, 0.009951334446668625, -0.0058663454838097095, 0.005133496597409248, -0.006802058778703213, 0.01612500101327896, 0.0006416289834305644, 0.012116586789488792, -0.019438615068793297, -0.03593926876783371, 0.005000043194741011, 0.006592052988708019, -0.025835026055574417, 0.011973734945058823, -0.0006316435756161809, 0.007815082557499409, 0.04059144854545593, 0.001400306005962193, -0.008054180070757866, -0.00242937752045691, -0.004145944025367498, -0.028716102242469788, 0.016584431752562523, -0.011537509970366955, -0.01044110581278801, -0.0027498528361320496, 0.027144890278577805, 0.016564778983592987, -0.009420960210263729, -0.010392576456069946, 0.0004274342209100723, -0.00426157983019948, -0.006144826300442219, -0.011777514591813087, 0.013611865229904652, 0.008828568272292614, -0.009173939004540443, 0.006282499060034752, -0.008575040847063065, 0.0045062340795993805, -0.009165477938950062, 0.0028473713900893927, -0.006573854945600033, 0.00742208119481802, 0.002877216786146164, 0.0067743537947535515, 0.01767858862876892, 0.0027107561472803354, 0.018930751830339432, 0.007666530087590218, 0.0027321046218276024, 0.06673564016819, -0.0038396227173507214, 0.03363526612520218, 0.008716349489986897, 0.013248958624899387, 0.020185600966215134, -0.007539865095168352, 0.02590120956301689, 0.0005373003659769893, 0.004566113464534283, 0.018225397914648056, 0.014934484846889973, 0.007057120092213154, -0.02207927033305168, 0.0015431265346705914, -0.023627538233995438, 0.003199188970029354, 0.015423120930790901, 0.005117286927998066, 0.015903135761618614, -0.031572021543979645, 0.002681154292076826, -0.01183735579252243, 0.03087402880191803, -0.02988935261964798, 0.013426562771201134, 0.0195639505982399, -0.016327794641256332, -0.01936575025320053, 0.0010940944775938988, -0.031095867976546288, 0.021517004817724228, -0.006444193422794342, 0.007175479084253311, 0.0022678268142044544, -0.008089536800980568, 0.007735360413789749, -0.014977917075157166, -0.007841640152037144, -0.011747926473617554, -0.012343691661953926, -0.0014888802543282509, -0.004302515182644129, 0.00854366086423397, 0.01719980686903, 0.019056688994169235, -0.01889222301542759, 0.00037932663690298796, 0.008748836815357208, 0.009715440683066845, -0.0031503650825470686, -0.006882716901600361, -0.03480612486600876, -0.015223883092403412, 0.03475775197148323, -0.003556901589035988, -0.021744374185800552, 0.013800387270748615, -0.020861972123384476, 0.018691543489694595, -0.012096086516976357, 0.013539181090891361, -0.006179101765155792, -0.006861812435090542, -0.0014380019856616855, 0.008766490034759045, -0.0021151616238057613, 0.02457563392817974, 0.006690853275358677, 0.0031574955210089684, 0.0031677819788455963, 0.008731488138437271, -0.013394614681601524, -0.023834437131881714, 0.020772553980350494, -0.005632470361888409, -0.022565949708223343, -0.009381129406392574, 0.009719399735331535, 0.026378940790891647, 0.003458272200077772, 0.010674586519598961, 0.005257470533251762, -0.01101029571145773, 0.0249185673892498, -0.0040900311432778835, 0.0049761319532990456, 0.004816052503883839, -0.013085037469863892, -0.0015687854029238224, -0.006510263774544001, 0.010673180222511292, -0.003880387172102928, -0.00478639081120491, -0.08154582232236862, -0.022075576707720757, -0.01538399513810873, -0.01484230998903513, 0.006185440346598625, 0.028393227607011795, 0.019843019545078278, -0.01381145790219307, 0.000178735819645226, 0.003272729692980647, -0.006587447132915258, 0.014852941036224365, -0.0019180257804691792, -0.0358799584209919, 0.03682958334684372, -0.01027622539550066, 0.014233966358006, -0.014111515134572983, 0.0028635873459279537, -0.031068161129951477, 0.01436077430844307, 0.00027172151021659374, 0.005757673643529415, -0.007897499948740005, 0.00485990010201931, 0.012198114767670631, 0.031913697719573975, -0.007731796707957983, -0.015361443161964417, 0.007700467947870493, -0.024195604026317596, 0.000017355196177959442, -0.015660177916288376, 0.0009734220802783966, 0.021552711725234985, 0.020996861159801483, 0.0028367850463837385, 0.0009080132003873587, -0.012180693447589874, -0.001407659612596035, -0.016263486817479134, 0.014125903137028217, 0.0038919721264392138, 0.01537198107689619, 0.0008437435608357191, 0.0084415627643466, -0.00458139693364501, 0.00398709811270237, 0.018865080550312996, -0.0012052501551806927, 0.005320900119841099, 0.005686047021299601, 0.022835832089185715, 0.026052597910165787, -0.01243136078119278, -0.006285489071160555, -0.007430198602378368, 0.01433261577039957, -0.006303702015429735, -0.0017148021142929792, 0.0013504642993211746, -0.03405802696943283, 0.005216662771999836, 0.005384576041251421, -0.019209444522857666, 0.02373015508055687, 0.015356791205704212, -0.004022395703941584, -0.0007831596303731203, -0.0016163344262167811, -0.0192329790443182, 0.004499705042690039, -0.01666780561208725, 0.0008603403111919761, -0.01595386490225792, -0.009354576468467712, -0.0097392238676548, -0.010401609353721142, 0.001412821002304554, -0.005147102754563093, -0.020340777933597565, 0.001978544984012842, -0.015299073420464993, -0.0135477464646101, -0.009073233231902122, -0.010642651468515396, 0.007546175736933947, 0.04810796678066254, 0.007772884331643581, -0.02096489816904068, 0.01254704687744379, 0.0016147939022630453, 0.021009553223848343, 0.008191049098968506, 0.009065554477274418, 0.021305467933416367, 0.018349669873714447, -0.006911987438797951, 0.009533204138278961, 0.00892062671482563, 0.007047546096146107, -0.00981568917632103, -0.025608498603105545, -0.0037645166739821434, -0.04030371457338333, 0.00982932560145855, 0.0015886235050857067, 0.012434344738721848, -0.011386500671505928, 0.005505322944372892, -0.006467465311288834, -0.021858245134353638, -0.0058014667592942715, 0.020117025822401047, 0.008232636377215385, 0.004924341104924679, -0.005773085169494152, -0.0035573868080973625, 0.07205670326948166, -0.007210658863186836, -0.0031677104998379946, -0.011754309758543968, 0.0327458418905735, -0.006157149560749531, -0.018633272498846054, 0.0046236878260970116, 0.0004275036044418812, 0.004571014083921909, 0.014177866280078888, -0.011219516396522522, 0.007817728444933891, -0.027766864746809006, -0.056347593665122986, 0.011463167145848274, -0.002245081588625908, 0.005416562780737877, 0.00901260506361723, 0.011185426265001297, -0.010321581736207008, -0.020156949758529663, 0.010052488185465336, 0.002600108738988638, -0.02097439207136631, -0.017527617514133453, -0.014158900827169418, -0.014368284493684769, -0.03316798806190491, 0.006661701016128063, -0.00681797880679369, -0.021766487509012222, -0.008942924439907074, -0.006554411258548498, -0.0021662209182977676, 0.027063926681876183, -0.015105336904525757, -0.008459817618131638, -0.0017858532955870032, -0.008424168452620506, -0.004706760868430138, -0.016908105462789536, 0.004416431300342083, 0.005627014674246311, -0.003151887096464634, -0.009524645283818245, 0.010026589967310429, -0.007093259133398533, 0.006235250271856785, -0.005580686964094639, -0.010555308312177658, 0.0034650745801627636, 0.012411212548613548, 0.022428281605243683, 0.0019559289794415236, 0.009939111769199371, -0.004095866810530424, -0.006620913278311491, -0.0001684781163930893, 0.00371765298768878, -0.02001982182264328, 0.010079491883516312, -0.014482545666396618, 0.0045202430337667465, -0.0002461550757288933, -0.006644179113209248, -0.02862614393234253, 0.01721172034740448, 0.008718162775039673, 0.028465308248996735, -0.020729724317789078, 0.004249345511198044, 0.005357924848794937, 0.018007105216383934, -0.009057192131876945, 0.005466544069349766, 0.007492762990295887, -0.008428774774074554, 0.01359473541378975, -0.010584388859570026, 0.028707265853881836, -0.00010302371811121702, 0.00784566905349493, 0.0054599083960056305, -0.023335561156272888, -0.006471667438745499, -0.009290286339819431, -0.07541421055793762, -0.027323998510837555, -0.005799827165901661, -0.0007157273357734084, -0.0073126498609781265, -0.015236839652061462, -0.022273849695920944, -0.005117224529385567, 0.01592068187892437, -0.0033014691434800625, -0.016784969717264175, 0.018225137144327164, 0.013305025175213814, -0.0019191480241715908, 0.014667801558971405, 0.017622854560613632, 0.0013692593201994896, 0.006720339879393578, -0.023297514766454697, -0.004586859606206417, -0.012053162790834904, 0.033312831073999405, -0.011052548885345459, 0.0024117943830788136, -0.0011308365501463413, -0.0806565135717392, -0.029928382486104965, 0.005933079868555069, 0.04204874113202095, -0.00046239548828452826, 0.01570834219455719, -0.01817767135798931, -0.006035287398844957, 0.00296192429959774, -0.016593264415860176, 0.033385004848241806, -0.005507651716470718, 0.02319354936480522, -0.009035876952111721, 0.007304182276129723, -0.007989199832081795, 0.007696730550378561, 0.007635555695742369, -0.01222015731036663, 0.01915634609758854, 0.004861022345721722, -0.003618659684434533, -0.011136919260025024, 0.0027894771192222834, -0.0013393310364335775, -0.017796607688069344, 0.007928415201604366, 0.012506673112511635, 0.01902266964316368, -0.0028414304833859205, -0.006494138389825821, 0.011990047991275787, -0.010053380392491817, -0.017431337386369705, -0.02944294735789299, -0.016991594806313515, -0.012384345754981041, -0.006418475415557623, 0.010211821645498276, -0.010366082191467285, -0.005842833314090967, -0.014535900205373764, 0.005154505837708712, -0.015329450368881226, -0.006562891416251659, 0.006937564816325903, 0.005921175703406334, -0.01831907406449318, 0.008394736796617508, -0.014010279439389706, 0.010592926293611526, 0.039971061050891876, 0.006347697228193283, 0.005363106727600098, -0.007902154698967934, 0.003991441801190376, -0.0007403175113722682, 0.02454342320561409, 0.02793283388018608, 0.014106398448348045, 0.0005408796714618802, 0.021042849868535995, 0.003230663249269128, 0.07160194218158722, 0.006705602165311575, 0.0091004753485322, -0.010174043476581573, -0.0025006721261888742, 0.005693042650818825, 0.014783050864934921, -0.02924085408449173, -0.006230128463357687, -0.01434879656881094, 0.016496416181325912, -0.0024613025598227978, 0.02681685984134674, 0.005560853518545628, 0.002843881258741021, 0.022305671125650406, -0.0008539087139070034, 0.01694886013865471, -0.003672611666843295, 0.023428291082382202, 0.003111979691311717, 0.02587657794356346, -0.026181351393461227, -0.004589608404785395, 0.011496191844344139, -0.018019849434494972, 0.011205542832612991, 0.011546893045306206, 0.002243275288492441, 0.0025461209006607533, 0.0019113891758024693, -0.01910603977739811, 0.006236367858946323, 0.01457400806248188, -0.005112386308610439, 0.0187536533921957, -0.007286868989467621, 0.01050671748816967, -0.03350155055522919, -0.04194123297929764, -0.021699074655771255, -0.016822660341858864, -0.0059253498911857605, -0.005937714129686356, -0.007276017684489489, -0.0011366726830601692, 0.009312737733125687, -0.0006367370951920748, -0.011042454279959202, 0.02389048971235752, 0.0014499519020318985, 0.005281874909996986, 0.0040728747844696045, -0.00745873199775815, 0.030236687511205673, -0.02691071853041649, -0.03896837681531906, 0.02177540399134159, 0.0013724598102271557, -0.013206210918724537, -0.0002913977950811386, -0.010148443281650543, 0.04124195873737335, -0.007372148800641298, 0.03453664854168892, -0.007546608801931143, 0.02661857381463051, -0.012195071205496788, 0.006840628571808338, 0.011664625257253647, 0.015203987248241901, 0.008629957213997841, 0.007389224600046873, -0.00777689553797245, -0.004747202154248953, 0.006952005438506603, -0.012365300208330154, -0.01023170817643404, 0.025113796815276146, -0.0014281664043664932, -0.013674136251211166, 0.013999227434396744, 0.009631205350160599, 0.011079186573624611, 0.012766538187861443, 0.007936450652778149, -0.019290544092655182, 0.04172100871801376, -0.0032386709935963154, 0.009809348732233047, 0.0034641032107174397, -0.009440310299396515, -0.007432532962411642, 0.005676976405084133, 0.008289186283946037, 0.03527934476733208, -0.004560097586363554, 0.00891146995127201, 0.006194155663251877, -0.013261225074529648, -0.012706022709608078, 0.0403924435377121, -0.026153478771448135, -0.020799651741981506, 0.0018179148901253939, -0.011204998940229416, 0.04437536746263504, 0.01504836417734623, 0.012443536892533302, 0.0324004627764225, 0.018165498971939087, 0.0015699438517913222, -0.02257522940635681, -0.006297607906162739, 0.013592517003417015, 0.026158424094319344, -0.014005755074322224, 0.028693877160549164, -0.015325835905969143, -0.009213661774992943, -0.030725447461009026, -0.002496180357411504, -0.008082873187959194, 0.012264853343367577, -0.025361809879541397, -0.015241285786032677, -0.004380363970994949, -0.01938200369477272, 0.011083913967013359, -0.004198756534606218, 0.015693141147494316, 0.011301613412797451, 0.022178519517183304, -0.0025243540294468403, -0.013750355690717697, -0.013616996817290783, -0.012662893161177635, 0.01600508950650692, 0.01665295474231243, 0.0035750798415392637, 0.016615498811006546, -0.016499727964401245, 0.0059361765161156654, -0.0027640610933303833, 0.008268151432275772, -0.005064443685114384, -0.0006885668262839317, 0.006988298147916794, 0.006921104621142149, -0.008913550525903702, 0.01550152525305748, 0.012981653213500977, -0.015255466103553772, -0.0031922212801873684, -0.027262136340141296, 0.008947732858359814, 0.01735483855009079, -0.013621384277939796, 0.006700260564684868, -0.012278355658054352, -0.011170070618391037, 0.029955875128507614, -0.0352524071931839, 0.0009276388445869088, -0.006300380453467369, -0.0037307911552488804, -0.002046874724328518, -0.014440484344959259, -0.01508865412324667, -0.020596038550138474, -0.004876129794865847, 0.00010498473420739174, -0.009640482254326344, 0.03315945342183113, -0.027273301035165787, -0.00278264912776649, -0.006244868040084839, -0.011530838906764984, 0.018249813467264175, 0.0059583913534879684, 0.005520259961485863, -0.0035059337969869375, -0.00031634746119379997, -0.005209921859204769, -0.0037518294993788004, -0.014352217316627502, 0.0031084606889635324, -0.025538671761751175, 0.023316260427236557, 0.024500172585248947, -0.00966915488243103, 0.004215155728161335, -0.014043434523046017, -0.009491968899965286, -0.019185714423656464, 0.003262108191847801, 0.014166443608701229, -0.004354620352387428, 0.005167211405932903, 0.010051997378468513, 0.020214930176734924, -0.025501122698187828 ]
[ -0.19931118190288544, -0.41562262177467346, 0.6582109332084656, -0.07419347763061523, -0.2096567302942276, 0.3597421944141388, 0.03355126082897186, -0.00908854603767395, -0.39930790662765503, -0.5521364212036133, -0.04552768915891647, -0.0973111018538475, -0.5046076774597168, 0.19956743717193604, 0.06545081734657288, 0.5298106074333191, 0.3746119439601898, 0.01223838236182928, -0.2527361512184143, -0.7018525004386902, 0.09770625829696655, -0.0637054517865181, 0.6346039772033691, -0.31423819065093994, 0.2736622393131256, -0.7304902672767639, 0.14618007838726044, 0.3135263919830322, 0.2873910665512085, -0.016941532492637634, -0.5994820594787598, 0.3234012722969055, 0.21490159630775452, -0.023693226277828217, -0.02689608372747898, 0.3518950045108795, -0.4565754234790802, -0.14839358627796173, -0.15901106595993042, -0.14708678424358368, -0.7597383856773376, -0.275900274515152, -0.3936122953891754, 0.5924304127693176, -0.2783550024032593, 0.16491293907165527, -1.1562631130218506, 0.7973500490188599, -0.18285420536994934, 0.13047808408737183, 0.013549075461924076, 0.5425410270690918, 0.7903075814247131, -0.0228121280670166, 0.15955893695354462, -0.1614409238100052, -0.7687210440635681, 0.20979833602905273, 0.37338483333587646, -0.8418041467666626, 0.3720886707305908, 0.602627694606781, -0.1618121713399887, -0.06233391910791397, -0.3587995767593384, 0.2704315781593323, 0.06515445560216904, -0.49488046765327454, -0.13873432576656342, 0.2421957403421402, -0.12188605219125748, -0.21865276992321014, -0.22351209819316864, 0.4475419521331787, -0.3967999815940857, 0.0409863106906414, 0.07878437638282776, 0.5121810436248779, -0.09796793758869171, 0.36013469099998474, -0.366344690322876, -0.0813305526971817, 0.7076659798622131, -0.03679339960217476, 0.6199575066566467, 0.001856024842709303, -0.28950077295303345, 0.28303173184394836, -0.2854466736316681, -0.2873707413673401, -0.7525438666343689, 0.07041499018669128, 0.2984142601490021, 0.6396064162254333, -0.03435642644762993, 0.27151256799697876, 0.45120349526405334, 0.052549198269844055, -0.26849332451820374, 0.3047076165676117, -0.22369371354579926, 0.22304266691207886, 0.3197624385356903, -0.036579426378011703, 0.00982547178864479, -0.6652616858482361, 0.1901835948228836, -0.44856464862823486, -0.5392082929611206, 0.0500633604824543, -1.3573238849639893, -0.10106971114873886, 0.12780070304870605, -0.5586681365966797, 0.11289799958467484, 0.06942065060138702, -0.38292816281318665, -0.22352148592472076, -0.37726891040802, -0.11530737578868866, -0.4087585210800171, 0.8484323620796204, -0.1366804987192154, 0.47789230942726135, -0.33961382508277893, -0.08701487630605698, 0.3594081699848175, -0.5046122074127197, -0.03008352592587471, 0.7403630614280701, 0.22984997928142548, 0.4814622402191162, -0.008009019307792187, 0.13681180775165558, -0.406466543674469, -0.034510537981987, 0.5368513464927673, 0.4623050391674042, 0.6352040767669678, 0.015097790397703648, -1.1248582601547241, -0.44108080863952637, -0.6584707498550415, -0.20568032562732697, -0.04797608405351639, -0.33739253878593445, -0.0022094182204455137, 0.0717850998044014, -0.2376932054758072, -0.48165562748908997, -0.2742096483707428, -0.21465063095092773, -0.26651597023010254, -0.4257006347179413, 0.14346618950366974, 0.575410783290863, -0.14441794157028198, -0.25830772519111633, 0.23190513253211975, -0.04180852323770523, 0.2267373949289322, -0.012131721712648869, 0.009932572022080421, -0.13121040165424347, 0.3497306704521179, -0.07716616243124008, 0.35596442222595215, -0.03615553677082062, 0.22303903102874756, 0.1924123466014862, -0.2185569852590561, -0.5028658509254456, 0.3729000687599182, -0.5659369230270386, -0.4405387341976166, -0.353823184967041, 0.2039368599653244, 0.1929062008857727, 0.10438227653503418, -0.36687561869621277, -0.5686818361282349, -0.11142387986183167, 0.3459048271179199, -0.3909115493297577, 0.18008236587047577, -0.25913798809051514, 0.6126247644424438, -0.38157737255096436, 0.22443994879722595, -0.17718647420406342, 0.27586162090301514, -0.5371320843696594, 0.4909054934978485, -0.7323561906814575, 1.1644865274429321, -0.2716994285583496, -0.1063631996512413, 0.552057147026062, 0.6274951696395874, 0.14313991367816925, 0.1304490864276886, -0.13244442641735077, 0.42746737599372864, -0.24410562217235565, -0.1851847767829895, 0.10788297653198242, -0.502800703048706, -0.4110462963581085, 0.4139522612094879, 0.2616853415966034, 0.3702561557292938, -0.5661484003067017, -0.137299582362175, -0.06614258140325546, 0.443805068731308, -0.5589305758476257, 0.05485258251428604, -0.10041734576225281, 0.04489731043577194, -0.34465858340263367, 0.1755976378917694, -0.38806188106536865, 0.6770297884941101, 0.5247650146484375, -0.2507483959197998, 0.7357726097106934, 0.3241000771522522, 0.12714700400829315, 0.7893691658973694, -0.20182955265045166, 0.30242931842803955, -0.20642024278640747, 0.008385630324482918, -0.2891041040420532, 0.15117321908473969, 0.01762833259999752, 0.6490404009819031, -0.2658613920211792, -0.5846480131149292, -0.08889299631118774, 0.021335424855351448, 0.8330434560775757, -0.6579321026802063, -0.1235228180885315, -0.07050880044698715, -0.5216540098190308, -0.08640146255493164, 0.6944400072097778, -0.8350458741188049, -0.049846239387989044, 0.024420030415058136, 0.5663583874702454, -0.12293124198913574, -0.6246488690376282, -0.5330035090446472, 0.17408210039138794, -0.4203994870185852, -0.532067060470581, 0.5146833658218384, -0.4535629451274872, 0.1339275985956192, 0.38274523615837097, 0.041951559484004974, 0.33415037393569946, 0.1279183179140091, -0.4851726293563843, -0.2822565734386444, -0.6332941055297852, 0.8882192373275757, 0.6610996723175049, 1.065820574760437, -0.20092980563640594, -0.42283234000205994, -0.08832263946533203, -0.5538191199302673, -0.4453098475933075, -0.05806346237659454, -0.1664419025182724, -0.2667970657348633, -0.4248262643814087, 0.12451404333114624, 0.12205196171998978, 1.2473185062408447, 0.43023571372032166, -0.2753544747829437, -0.12156558781862259, -0.20823684334754944, -0.04575598984956741, 0.2471718192100525, -0.6028735637664795, -0.06311063468456268, 0.18589286506175995, -0.4968484938144684, 0.18837401270866394, 0.19365352392196655, 0.2938782274723053, 0.04605725035071373, 0.7259989380836487, 0.41034919023513794, -0.12207083404064178, -0.3448478877544403, -0.39292585849761963, -0.4881393015384674, 0.17245914041996002, -0.0738205835223198, -0.11174853891134262, -0.4365108013153076, 0.23472240567207336, -5.6798248291015625, 0.05800357833504677, -0.25113216042518616, -0.28591251373291016, 0.03601692244410515, -0.2809506952762604, 0.6984509825706482, 0.06517957895994186, 0.044011831283569336, 0.03460990637540817, -0.036702487617731094, 0.26665905117988586, -0.05057356879115105, 0.22773988544940948, -0.5676576495170593, 0.02223898284137249, -0.07931622862815857, -0.23969276249408722, 0.4972672760486603, -0.006901406217366457, 0.1379115879535675, -0.3884345591068268, -0.2162613570690155, 0.7820913791656494, 0.18180766701698303, 0.6523199081420898, -0.7606287002563477, -0.20209570229053497, -0.5021212697029114, -0.6906697154045105, -0.5345757007598877, -1.161536693572998, -0.5278658270835876, 0.11016155779361725, 0.8561251163482666, 0.33176732063293457, 0.23772943019866943, 0.3280911445617676, -0.08923604339361191, -0.5580836534500122, 0.19926372170448303, 0.23867768049240112, -0.2066277265548706, 0.040868327021598816, 0.6892919540405273, 0.43668872117996216, -0.6217949390411377, 0.18031592667102814, -0.3553377687931061, 0.4837331175804138, -0.01122906245291233, -0.08746255934238434, 0.203551784157753, 0.4941083788871765, 0.5483976602554321, 0.24809357523918152, -0.031284358352422714, -0.4626801609992981, 0.0005020678509026766, 0.04437931999564171, -0.1545351892709732, -0.22184956073760986, -0.38632360100746155, -0.852258026599884, -0.2750031352043152, 0.4985867738723755, -0.5503407716751099, 0.1414400190114975, 0.7083930969238281, 0.20270182192325592, -0.026179611682891846, -0.1492333561182022, 0.41271907091140747, -0.6336255073547363, 0.5741931796073914, -0.16947521269321442, 0.045332279056310654, 0.20951434969902039, 0.03959168121218681, 0.017605802044272423, -0.23932628333568573, 0.12683674693107605, 0.33162909746170044, -0.2196781039237976, 0.005748487543314695, -0.09793851524591446, -0.25302910804748535, 0.030773958191275597, -0.47722727060317993, 0.48531320691108704, 0.11680564284324646, -0.32667407393455505, -0.1482791006565094, 0.544353723526001, 0.14205195009708405, 0.41338375210762024, 0.2506714463233948, 0.5683506727218628, 0.2821297347545624, 0.03164594620466232, 0.7779768109321594, -0.5256677269935608, -0.592225193977356, -0.13777032494544983, -0.4255046844482422, 0.5469506978988647, -1.0394245386123657, 0.2429746687412262, 0.8111870884895325, -0.30952128767967224, 0.47117820382118225, 0.1970604658126831, -0.5472976565361023, -0.36380112171173096, 0.5776032209396362, 0.24184133112430573, -0.5650488138198853, 0.12007541209459305, 0.4782007932662964, -0.4758065342903137, -0.16676339507102966, -0.1328601837158203, -0.7560530304908752, 0.24824941158294678, -0.06192362681031227, -0.028485167771577835, 0.20990237593650818, 0.9032018184661865, -0.4422982335090637, -0.05740192160010338, 0.3281848132610321, 0.22844986617565155, -0.23541031777858734, 0.12267152965068817, -0.22983048856258392, -0.6956828832626343, -0.018588904291391373, 0.1310427188873291, 0.6130310297012329, -0.26218321919441223, -0.20854757726192474, -0.03499764949083328, 0.04545750841498375, -0.26356834173202515, 0.19111061096191406, -0.09841649234294891, 0.06815747916698456, -0.12388788163661957, -0.36576366424560547, -0.3077760934829712, 0.5612824559211731, -0.32775789499282837, 0.44124165177345276, 0.18918566405773163, -0.5326315760612488, -0.2890600860118866, 0.4939901530742645, 0.34815576672554016, -0.007920388132333755, -0.08412083238363266, 0.5040267705917358, -0.49809378385543823, -0.4342980980873108, 0.2568380832672119, -0.5872282385826111, -0.11361285299062729, 0.26017698645591736, -0.5492423176765442, 0.07580184191465378, -0.07148415595293045, -0.21022172272205353, -0.7276812195777893, 0.3333416283130646, -0.21897248923778534, 0.3762100338935852, -0.637053906917572, -0.08160977810621262, 0.3803420066833496, 0.06330440938472748, 0.26225271821022034, -0.07627497613430023, -0.37739846110343933, -0.4753204882144928, 0.3210083842277527, 0.49001529812812805, 0.21130037307739258, 0.047507382929325104, -0.04156194627285004, 0.15967828035354614, -0.45579904317855835, 0.24092546105384827, 0.4753645956516266, 0.3554838001728058, -0.5856712460517883, 0.5281338095664978, -0.08312034606933594, 0.7184669971466064, 0.9957278370857239, -0.24455907940864563, -0.35166510939598083, 0.2717059254646301, 0.1841084361076355, -0.3591914474964142, 0.7697599530220032, 0.7977907657623291, 0.19590109586715698, -0.07018157094717026, -0.1359340101480484, -0.37033891677856445, -0.1872560977935791, -0.3138824999332428, -0.4021837115287781, -0.24160076677799225, 0.17578041553497314, -0.1720273792743683, -0.079236701130867, 0.2527703046798706, -0.5957900285720825, -0.34705379605293274, 0.6408527493476868, 0.2989186644554138, -0.15058565139770508, -0.07224439084529877, -0.14120091497898102, -0.40704983472824097, 0.4162597060203552, 0.6434447169303894, -0.607498288154602, 0.12839844822883606, -0.1654115915298462, 0.2500939667224884, 0.23953761160373688, 0.06572312861680984, 0.219744011759758, -0.25884199142456055, -0.40361684560775757, -0.07646401226520538, 0.0159828532487154, -0.3941267728805542, 0.7344873547554016, 0.3829349875450134, 0.8234858512878418, -0.18047261238098145, -0.10305573046207428, -0.02233530953526497, 0.5350795388221741, 0.19505901634693146, -0.5662042498588562, -0.22316309809684753, 0.11325423419475555, 0.9713811278343201, -0.5766522288322449, -0.24227766692638397, 0.6110993027687073, 1.4593889713287354, -0.638811469078064, -0.11581164598464966, -0.35983309149742126, -0.10246898978948593, 0.3562667965888977, 0.16118629276752472, -0.13718926906585693, -0.31460580229759216, 0.5817133188247681, 0.1186797097325325, -0.00941633153706789, -0.2834166884422302, -0.32527682185173035, 0.5574268102645874, -0.7823277115821838, 0.12496448308229446, 0.028567323461174965, 0.3620550334453583, 0.23372426629066467, 0.3897815942764282, 0.02565326914191246, -0.011667193844914436, 0.15879812836647034, 0.25803810358047485, -0.516335666179657, -0.42161694169044495, -0.5262260437011719, 0.5363149046897888, -0.34337592124938965, 0.6736572980880737, -0.8194409608840942, -0.21650290489196777, -0.8097442388534546, -0.5139250755310059, -0.2388773113489151, 0.0015604097861796618, -0.055284082889556885, -0.10822613537311554, -0.4466273784637451, -0.280891090631485, 0.4440116286277771, 0.10976746678352356, -0.2822015881538391, 0.41715681552886963, -0.0711965411901474, -0.4137582778930664, 0.7019703388214111, 0.20268720388412476, 0.1485118269920349, -0.3418020009994507, 0.024520622566342354, 0.2556701898574829, -0.6189916133880615, -0.4780919551849365, -0.569389820098877, 0.46482136845588684, -0.2347109168767929, 0.4577329754829407, 0.03136282414197922, -0.39905598759651184, 0.23561325669288635, -0.005280069075524807, -0.08104850351810455, -0.012891335412859917, 0.3998369574546814, 0.22411377727985382, 1.1189651489257812, 0.3170650601387024, 0.06317413598299026, 0.6018141508102417, 0.15449829399585724, 0.5752115845680237, 0.04933030530810356, 0.36006098985671997, 0.16532060503959656, 0.9031044244766235, 0.32143402099609375, -0.019501231610774994, 0.7120343446731567, 0.6699885725975037, 0.1457429975271225, -0.08668813854455948, -0.26431381702423096, -0.4406528174877167, 0.06838714331388474, 0.845325767993927, 0.24312253296375275, -0.5459532141685486, -0.0473230816423893, 0.29372313618659973, 0.21242547035217285, 0.2692275643348694, -0.15745602548122406, -0.00843020062893629, 0.6659598350524902, 0.11754435300827026, -0.3796609044075012, -0.4178968369960785, 0.12323351949453354, -0.4086543619632721, 0.49238958954811096, 0.640351414680481, -0.24608275294303894, -0.8067859411239624, 0.3905656039714813, -0.4005363881587982, 0.48734143376350403, -0.053005803376436234, 0.45906323194503784, 0.0019189497688785195, -0.10508287698030472, -0.17790651321411133, -0.17446772754192352, 0.12405139207839966, -0.3237331509590149, 0.24823331832885742, 0.21832306683063507, -0.09399858862161636, -0.1071084663271904, 0.14681603014469147, 0.13535183668136597, 0.23452702164649963, 0.15361323952674866, 0.21804533898830414, 0.49051740765571594, -0.14917652308940887, 0.2653244137763977, 0.09194205701351166, -0.29664433002471924, 0.18633782863616943, -0.4470943510532379, -0.6036016941070557, 0.06158807501196861, -0.49013787508010864, 0.1549658477306366, 0.06729292869567871, -0.8436263799667358, 0.5045661330223083, -0.11354447901248932, 0.3766148090362549, 0.1269722431898117, -0.3592608869075775, -0.021392853930592537, 0.27795735001564026, -0.02701563946902752, -0.11637856811285019, 0.6259046196937561, -0.4882008731365204, 0.5256174206733704, -0.04344775155186653, 0.7300809621810913, -0.989953339099884, -0.7497785091400146, -0.31504711508750916, 0.05557135492563248, 0.9881515502929688, 0.5504237413406372, -0.46210014820098877, 0.3284212052822113, 1.0393682718276978, 0.7885246276855469, 0.1791686862707138, -0.5738582015037537, -0.27337440848350525, -0.41218531131744385, -0.07155042141675949, -0.3473242521286011, 0.3361138105392456, -0.0046054888516664505, -0.18460889160633087, -0.02821902558207512, 0.6008047461509705, -0.0227750763297081, -0.33011743426322937, 0.16150128841400146, 0.32108739018440247, -0.2354394942522049, -0.9189009666442871, 0.11606065928936005, -0.4811180531978607, 0.30561068654060364, -0.08997408300638199, 0.22053423523902893, -0.04183519259095192, -0.15258321166038513, 0.21334239840507507, -0.2804955244064331, -0.12578780949115753, -0.025361191481351852, -0.10384520888328552, 0.023219194263219833, -0.09540849924087524, -1.123494267463684, -0.8217001557350159, 0.4187454581260681, -0.07263162732124329, -0.30803897976875305, -0.0911734402179718, 0.18509598076343536, -0.08906026184558868, -0.21119657158851624, -0.25788095593452454, -0.6260711550712585, -0.42785221338272095, 0.04199795424938202 ]
Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The IL-33 receptor, consisting of ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 (TH2) cells and mast cells. IL-33 is host-protective against helminth infection and reduces atherosclerosis by promoting TH2-type immune responses. However, IL-33 can also promote the pathogenesis of asthma by expanding TH2 cells and mediate joint inflammation, atopic dermatitis and anaphylaxis by mast cell activation. Thus IL-33 could be a new target for therapeutic intervention across a range of diseases.
[ 0.005575976334512234, 0.0018583385972306132, -0.02488591894507408, 0.006295517086982727, -0.009505320340394974, 0.0129205621778965, 0.008730730973184109, -0.017696019262075424, -0.00883038341999054, 0.00786844827234745, -0.004427737556397915, 0.000026156252715736628, 0.006512596271932125, 0.008010981604456902, -0.013136998750269413, -0.003754911944270134, -0.027927547693252563, 0.010540889576077461, 0.014354457147419453, 0.011455699801445007, -0.0005451410543173552, 0.004811174236238003, 0.008780401200056076, -0.0016806633211672306, 0.021935224533081055, 0.01968660205602646, 0.023596249520778656, -0.0010100300423800945, -0.02246905118227005, -0.010408061556518078, 0.019394339993596077, 0.01014618668705225, 0.01614529639482498, 0.018483448773622513, 0.008244507946074009, -0.0032308739610016346, -0.008606337010860443, 0.022374264895915985, 0.03336801007390022, -0.0032794615253806114, 0.005003427155315876, -0.01086269412189722, 0.0035565150901675224, 0.0060334643349051476, -0.00608753552660346, -0.007860333658754826, -0.003401192370802164, -0.004299000836908817, 0.0016897628083825111, 0.0022508823312819004, -0.002292850986123085, -0.011931469663977623, -0.01663990318775177, 0.02033713087439537, -0.004755312576889992, 0.02571849897503853, 0.015657464042305946, -0.01165536604821682, 0.0012259039795026183, 0.03356405720114708, -0.001690492033958435, -0.02898888848721981, 0.009323127567768097, -0.01811268925666809, 0.001816063653677702, -0.06646054238080978, 0.010434847325086594, -0.009316105395555496, 0.00702940858900547, -0.014241755940020084, -0.022004786878824234, 0.011288517154753208, -0.019827570766210556, -0.01953044906258583, -0.012579141184687614, -0.010518679395318031, -0.003360006958246231, 0.03135959431529045, 0.020785823464393616, 0.002530158031731844, -0.014220424927771091, -0.0031310091726481915, 0.03820747882127762, 0.005490294191986322, 0.006109928712248802, 0.0011887811124324799, -0.022451823577284813, -0.015353705734014511, -0.007461529225111008, -0.021694138646125793, -0.004821718204766512, 0.018972575664520264, 0.004875984974205494, -0.0021509567741304636, 0.01181316189467907, -0.007787710055708885, -0.030615588650107384, 0.0010176599025726318, -0.032291315495967865, 0.006420966703444719, -0.013542551547288895, -0.004098839592188597, 0.003943301271647215, 0.012421196326613426, 0.011664032936096191, 0.0050637307576835155, 0.01812484674155712, -0.004394779913127422, 0.008491981774568558, 0.005726303439587355, -0.009146246127784252, 0.007266978733241558, -0.00010259449481964111, 0.020383410155773163, 0.012448305264115334, -0.00795602984726429, -0.03627261519432068, 0.0018959537846967578, 0.009856479242444038, 0.006195658817887306, -0.028514314442873, 0.011094310320913792, -0.00029952661134302616, -0.011328643187880516, 0.0018621005583554506, -0.011815925128757954, 0.023329708725214005, -0.001645111246034503, -0.0029495712369680405, 0.007376823574304581, -0.004173594992607832, 0.012718838639557362, -0.0034073833376169205, 0.0016462057828903198, -0.0013712465297430754, -0.000974578142631799, -0.0007102375384420156, 0.020932156592607498, -0.016699325293302536, -0.026247818022966385, -0.013730527833104134, 0.010263608768582344, 0.010280036367475986, 0.012048538774251938, 0.027528388425707817, 0.007449518423527479, 0.023095114156603813, -0.00010517425835132599, 0.01661289483308792, -0.0009223977103829384, -0.009940193966031075, 0.0068552372977137566, 0.01917894184589386, -0.013406309299170971, 0.013727042824029922, 0.02270541712641716, -0.009621069766581059, -0.00882507674396038, 0.0015579902101308107, 0.0021554711274802685, -0.02275720238685608, -0.02566678449511528, 0.039144713431596756, 0.00835309736430645, 0.0074670929461717606, 0.02046646550297737, 0.010242069140076637, -0.020576734095811844, -0.005797848105430603, 0.006211309693753719, -0.002127318177372217, -0.0020190041977912188, -0.0111717339605093, 0.008083776570856571, -0.02307227998971939, -0.010738840326666832, 0.01145846862345934, 0.0055828578770160675, -0.0009928327053785324, 0.06647835671901703, 0.021471161395311356, -0.01570562645792961, 0.040841907262802124, -0.0035996204242110252, -0.009710229933261871, -0.0031523238867521286, 0.01320496853441, -0.009963060729205608, 0.01391163095831871, -0.012123788706958294, -0.011355560272932053, 0.014266491867601871, -0.036009982228279114, -0.007471609860658646, -0.03992653265595436, 0.0028802361339330673, 0.015320408158004284, 0.013093174435198307, 0.02041851542890072, 0.001580218318849802, 0.0033992710523307323, -0.022868560627102852, 0.009442202746868134, -0.04214847832918167, 0.0071935104206204414, 0.012210140004754066, 0.0006048046052455902, 0.0003630182472988963, -0.01825227215886116, -0.0021413257345557213, 0.02083485573530197, -0.019324759021401405, -0.024293720722198486, -0.015218948945403099, -0.01605909876525402, 0.018027756363153458, 0.007085189688950777, 0.003369612619280815, 0.02019389718770981, -0.011234043166041374, -0.0012348354794085026, 0.002804126590490341, 0.0018067723140120506, -0.01235046423971653, 0.019744399935007095, -0.00675247423350811, 0.0076799844391644, 0.006894471123814583, 0.0013648378662765026, 0.007347713224589825, -0.011419521644711494, -0.018797867000102997, -0.014365481212735176, 0.022535301744937897, 0.008505934849381447, -0.006037704646587372, 0.012050960212945938, -0.012636668980121613, 0.005146165378391743, -0.006389320828020573, -0.008991768583655357, 0.0016463713254779577, 0.025148402899503708, -0.03785896301269531, -0.02938656136393547, -0.002515482949092984, 0.01867000013589859, -0.01480193343013525, -0.027414536103606224, -0.02228626236319542, 0.007414639461785555, -0.028184067457914352, -0.02268403209745884, -0.0033941632136702538, 0.007466934621334076, -0.019367683678865433, 0.004108727443963289, -0.032660093158483505, 0.024319469928741455, 0.008305215276777744, -0.00599970668554306, 0.006146601401269436, -0.013068546541035175, 0.022261865437030792, -0.024971231818199158, 0.0020540375262498856, -0.018796510994434357, 0.02250303514301777, 0.013281113468110561, 0.007494550198316574, 0.009393135085701942, -0.0009918296709656715, 0.005511363036930561, -0.08093435317277908, -0.012068215757608414, -0.010608470998704433, -0.014149808324873447, 0.0082705644890666, -0.008195959031581879, 0.004096405580639839, 0.001431056298315525, -0.003356379456818104, 0.02776496112346649, 0.0010545721743255854, 0.019905345514416695, -0.01802043616771698, 0.003962921444326639, 0.0006676553748548031, -0.0008537003304809332, 0.011178769171237946, 0.0145783182233572, -0.018400060012936592, -0.025401772931218147, -0.00678994320333004, -0.023970669135451317, 0.024013929069042206, 0.006792681757360697, -0.00037251668982207775, -0.013628771528601646, 0.004515086766332388, 0.009721712209284306, -0.010769546031951904, -0.0036926865577697754, -0.013198460452258587, 0.012133808806538582, 0.024508293718099594, -0.0023682094179093838, 0.02617952600121498, 0.013704963959753513, -0.009314503520727158, -0.034772422164678574, -0.015238484367728233, -0.005502662621438503, -0.015104120597243309, 0.007992885075509548, 0.039092764258384705, 0.007049325853586197, 0.01904962956905365, 0.009950704872608185, 0.025017129257321358, 0.014039899222552776, 0.020363662391901016, 0.0004705418832600117, -0.014829952269792557, -0.0018598702736198902, -0.01935800164937973, 0.029549160972237587, -0.004671218805015087, -0.0027929842472076416, 0.007655389606952667, 0.016289010643959045, -0.004654301330447197, 0.004237843211740255, -0.002170523162931204, -0.008960811421275139, 0.03172718733549118, 0.014134470373392105, 0.010892908088862896, 0.01422162540256977, 0.006783082615584135, 0.008230065926909447, -0.01413680799305439, 0.0038324203342199326, -0.023241374641656876, 0.009014223702251911, -0.02013314701616764, -0.013134576380252838, -0.018794095143675804, -0.012999892234802246, -0.009381342679262161, -0.0046809702180325985, 0.01249100361019373, -0.0010003936477005482, -0.005041244439780712, 0.011232346296310425, 0.001125347800552845, -0.006719440221786499, -0.02590535208582878, -0.027584251016378403, 0.007991650141775608, 0.011328484863042831, 0.00994155928492546, -0.015893420204520226, 0.06416362524032593, 0.037303462624549866, 0.008929410949349403, 0.011795922182500362, -0.011518711224198341, 0.0061416300013661385, -0.017024070024490356, 0.02084541879594326, 0.014801278710365295, 0.007876930758357048, -0.007050496060401201, -0.0038243508897721767, -0.007901735603809357, -0.006042524706572294, -0.006958652287721634, 0.012699244543910027, -0.007490816991776228, 0.004828119650483131, -0.004762633703649044, 0.0030313150491565466, 0.011347572319209576, 0.00332713034003973, -0.004339220933616161, 0.013822752051055431, 0.0028940094634890556, 0.006581936962902546, -0.003162726294249296, -0.00823154766112566, 0.07190139591693878, -0.005707861389964819, -0.010267134755849838, -0.015018047764897346, 0.034121714532375336, 0.0020840473007410765, -0.02626204490661621, 0.005213249009102583, 0.0011569992639124393, 0.006574650295078754, 0.011741995811462402, 0.005720187909901142, -0.020138747990131378, 0.0014234920963644981, -0.01757022738456726, 0.009062130935490131, 0.00013227551244199276, -0.029726315289735794, 0.03605876863002777, -0.0035643114242702723, -0.017846470698714256, -0.01539320033043623, -0.0018817316740751266, -0.015161553397774696, 0.025563623756170273, -0.009311582893133163, 0.013659370131790638, -0.011289738118648529, -0.020974721759557724, 0.007991282269358635, -0.02277427725493908, -0.015357257798314095, -0.008915049955248833, 0.003950893878936768, 0.017347251996397972, -0.004425106104463339, 0.040317002683877945, -0.016976751387119293, 0.007140587083995342, -0.0023600736167281866, -0.006938641890883446, -0.01106213591992855, 0.018317032605409622, 0.0023395807947963476, -0.008646233007311821, 0.003099387511610985, 0.0016319609712809324, -0.00865308940410614, -0.006818790920078754, -0.0005954091902822256, -0.004685900639742613, 0.01010480709373951, 0.013844801113009453, -0.0058539994060993195, 0.01867276430130005, -0.021042168140411377, 0.014762995764613152, -0.006266401149332523, -0.001983486581593752, -0.027934100478887558, -0.03981747478246689, 0.001751632895320654, 0.015171417966485023, -0.006029801443219185, 0.0021302560344338417, -0.01407091598957777, 0.007264049723744392, -0.008735221810638905, 0.009005023166537285, -0.03143393248319626, 0.01588858664035797, 0.0005876098293811083, 0.0012818111572414637, 0.005109590012580156, -0.03663277626037598, -0.009163429960608482, 0.007109164260327816, -0.0008336007595062256, 0.016268335282802582, 0.0038523743860423565, 0.0062562827952206135, 0.022876016795635223, 0.0030875029042363167, -0.014730384573340416, 0.017960412427783012, -0.00005121552385389805, -0.012036949396133423, -0.07423090189695358, -0.006598202046006918, -0.004785280674695969, -0.002492864616215229, 0.001749418443068862, -0.0031229271553456783, -0.011309710331261158, 0.01461702585220337, -0.003709677839651704, -0.01191561110317707, 0.011068172752857208, 0.01178046502172947, -0.008709462359547615, 0.010539139620959759, 0.00861312821507454, -0.04205053299665451, 0.012941015884280205, -0.00038103689439594746, -0.000638970173895359, -0.015888379886746407, -0.02101518213748932, -0.024287104606628418, -0.012603260576725006, 0.012204045429825783, -0.012424614280462265, -0.08061621338129044, -0.006133888382464647, 0.010191943496465683, -0.006348933558911085, 0.001181887462735176, -0.03142819553613663, 0.009213888086378574, 0.0058575887233018875, -0.04704062268137932, -0.013947157189249992, 0.016545245423913002, 0.005740298889577389, -0.009834930300712585, -0.02133704163134098, -0.010049859993159771, -0.009427940472960472, 0.016918154433369637, 0.007572167553007603, 0.023025956004858017, -0.020076807588338852, -0.007117595989257097, 0.014589749276638031, -0.00896123144775629, -0.00478701526299119, -0.006868710275739431, -0.013888716697692871, -0.015916185453534126, 0.01571417599916458, -0.020439907908439636, -0.003809346118941903, -0.006538438145071268, -0.006925024092197418, -0.0255404282361269, -0.008344613015651703, -0.006073135416954756, -0.018315361812710762, 0.011948153376579285, -0.006409595720469952, -0.002133921254426241, -0.0009684672113507986, -0.010345043614506721, 0.015017343685030937, -0.001558233518153429, 0.013186657801270485, 0.017661575227975845, -0.004312116652727127, 0.005341190379112959, -0.003107447875663638, 0.0028167066629976034, 0.011963780969381332, 0.019311338663101196, -0.015917055308818817, 0.002253281883895397, 0.007339037489145994, 0.032324060797691345, 0.008500413969159126, -0.008919541724026203, 0.0031375735998153687, 0.00597982294857502, -0.0022676207590848207, -0.007780757267028093, -0.003055782988667488, 0.03831486031413078, 0.07111279666423798, -0.004664761014282703, 0.03520997613668442, -0.006743375211954117, 0.0019035213626921177, 0.005561063531786203, -0.01404104195535183, -0.005170127376914024, -0.010736366733908653, -0.022758163511753082, -0.008498522453010082, -0.01568935625255108, 0.035562675446271896, 0.015474178828299046, 0.009259052574634552, -0.028605181723833084, -0.005304725840687752, -0.012107105925679207, -0.030477536842226982, 0.018525417894124985, 0.005290086381137371, -0.004063962958753109, -0.0003138645552098751, -0.013276118785142899, 0.009530698880553246, -0.004866745788604021, -0.004064191598445177, 0.0028960921335965395, -0.025296274572610855, 0.028754733502864838, 0.003622103948146105, -0.00028771907091140747, 0.0010259230621159077, -0.001376548781991005, 0.02205790765583515, 0.0044554537162184715, -0.012263176031410694, 0.018619824200868607, -0.0024440016131848097, 0.010351083241403103, 0.021405264735221863, 0.004460168536752462, 0.0038238780107349157, -0.011959229595959187, 0.027917180210351944, 0.014315062202513218, 0.014590253122150898, -0.022240908816456795, 0.009079629555344582, 0.007740359753370285, 0.00918852724134922, -0.004028263967484236, -0.001185249537229538, -0.011987794190645218, 0.010021957568824291, 0.0009508419316262007, -0.006288728676736355, 0.0024930485524237156, -0.020327815786004066, -0.03413823992013931, 0.0009755024220794439, -0.012722590938210487, 0.012025652453303337, -0.01219238992780447, 0.02210134267807007, -0.00026090070605278015, 0.02089521288871765, -0.021448027342557907, 0.001219981350004673, 0.014844004064798355, -0.03714698553085327, -0.004629890900105238, 0.0101581159979105, 0.008624919690191746, 0.02666541375219822, 0.011928249150514603, 0.01356105599552393, -0.027148202061653137, 0.00981752946972847, 0.015363006852567196, -0.009706898592412472, 0.025364676490426064, -0.005769526120275259, 0.02988731488585472, -0.01883598417043686, -0.008866380900144577, 0.0016934261657297611, -0.007122264243662357, 0.006424007471650839, 0.005078920163214207, 0.013817762956023216, 0.0004719169810414314, 0.0097169429063797, 0.008076705038547516, 0.0025248138699680567, 0.03365509957075119, 0.0016727307811379433, 0.004485236015170813, -0.020125411450862885, 0.012435538694262505, 0.011925364844501019, -0.0069725969806313515, 0.006914051249623299, 0.015892349183559418, -0.015021460130810738, -0.0030727717094123363, -0.0373094379901886, 0.011422533541917801, -0.007094359025359154, -0.0016958978958427906, 0.014449258334934711, 0.010857464745640755, -0.006772981490939856, 0.03240025043487549, 0.00558262225240469, 0.028258752077817917, -0.0034827408380806446, 0.02025935798883438, -0.011057349853217602, -0.013364884071052074, 0.008813591673970222, 0.017021924257278442, -0.02317333221435547, 0.0006572299171239138, 0.010306735523045063, -0.00485259760171175, -0.006950270850211382, 0.03155066817998886, 0.027469951659440994, 0.02827773429453373, 0.02978241816163063, 0.022220954298973083, -0.005311921238899231, -0.0008651575772091746, 0.009423293173313141, 0.029141463339328766, 0.013295461423695087, 0.010665836744010448, 0.036380574107170105, -0.02332267165184021, -0.001364744734019041, -0.01658725179731846, -0.0027483704034239054, -0.0013781539164483547, 0.006593574769794941, 0.003417394822463393, -0.0285269096493721, -0.012939449399709702, 0.001243413775227964, 0.0004814350977540016, 0.015781912952661514, -0.005600092001259327, 0.007986035197973251, -0.007384178228676319, -0.0102425217628479, 0.022474372759461403, 0.009524106048047543, -0.0014845221303403378, -0.015682391822338104, -0.008341102860867977, -0.004410475492477417, -0.014755545184016228, 0.01083808857947588, 0.0013860177714377642, -0.0026452061720192432, -0.0372878760099411, 0.017896361649036407, 0.01178183313459158, 0.015649424865841866, -0.013293400406837463, 0.02630952000617981, -0.010641342028975487, 0.0064262691885232925, 0.034926533699035645, 0.0037343648727983236, -0.005185076501220465, 0.005723576061427593, 0.02145965024828911, 0.03608178347349167, -0.007235986180603504, -0.001079443609341979, -0.012897233478724957, 0.0024113545659929514, -0.004384125582873821, 0.004454438108950853, -0.018192028626799583, -0.01665775291621685, 0.004122801125049591, -0.0012514539994299412, -0.012110128998756409, -0.00261891633272171, -0.02220364660024643, -0.0011325650848448277, 0.00643465481698513, 0.006516902707517147, 0.01540469005703926, -0.02200350910425186, -0.02527356706559658, 0.00042342825327068567, 0.0005425349809229374, 0.00310753146186471, 0.009634824469685555 ]
[ -0.3585222065448761, -0.20629280805587769, 0.16474545001983643, -0.23503156006336212, -0.4252505600452423, 0.26792871952056885, 0.20729391276836395, -0.38316649198532104, 0.05543377995491028, -0.6977242827415466, -0.014259163290262222, 0.298972487449646, -0.7689005136489868, -0.0026519885286688805, 0.14862385392189026, 0.39308348298072815, 0.11465546488761902, 0.6806700229644775, -0.3471706211566925, -0.142417773604393, -0.054838016629219055, -0.27169477939605713, 0.18056534230709076, 0.10928085446357727, 0.42060378193855286, -0.30273959040641785, 0.10586289316415787, -0.05680974945425987, 0.872935950756073, -0.10037559270858765, -0.13449619710445404, 0.48623934388160706, -0.3192679286003113, -0.1463879644870758, -0.5682295560836792, -0.157495379447937, -0.623296320438385, -0.08038587123155594, 0.26219961047172546, 0.4477788507938385, -0.3554973006248474, -0.058412306010723114, -0.3651731610298157, 0.3983159065246582, -0.10090503096580505, -0.2256769984960556, -1.5191192626953125, 1.093889594078064, -0.015252296812832355, 0.1124357134103775, -0.32634302973747253, 0.22131413221359253, 0.22961540520191193, 0.06266401708126068, 0.39263713359832764, -0.027321072295308113, -0.9407395124435425, -0.008120269514620304, 0.5367969274520874, -0.6803595423698425, -0.1905549019575119, 0.2922547459602356, -0.022845758125185966, 0.07913444191217422, -0.15431278944015503, 0.6669704914093018, -0.08523549139499664, -0.2270185649394989, -0.9171949625015259, -0.38629522919654846, -0.13272668421268463, -0.3365476727485657, -0.2148585468530655, -0.057017162442207336, 0.5244265794754028, -0.5786939859390259, -0.7575808167457581, -0.3256373107433319, 0.011852426454424858, 0.7173562049865723, 0.061296869069337845, 0.3301377594470978, 0.13038747012615204, -0.21675346791744232, 0.5952420830726624, -0.19011518359184265, -0.5952099561691284, 0.8712912797927856, -0.5092479586601257, -0.40130195021629333, 0.3237166702747345, 0.23894238471984863, 0.7975165247917175, -0.03502851352095604, 0.37941408157348633, 0.4613294303417206, -0.16012617945671082, 0.09178034216165543, -0.26829439401626587, 0.4392291009426117, -0.04415970295667648, 0.27004194259643555, -0.01995770074427128, -0.8813816905021667, -0.7002285718917847, -0.055362749844789505, -0.04343399778008461, -0.720102846622467, -0.3857831060886383, 0.26945146918296814, -0.8171606659889221, -0.3890593349933624, -0.47693777084350586, -0.3033997714519501, -0.10507632791996002, -0.021983856335282326, 0.2071646749973297, -0.24570013582706451, 0.24748004972934723, 0.1975938230752945, -0.4188980758190155, 0.8732549548149109, -0.16136519610881805, 0.6469693183898926, 0.09304056316614151, -0.0872180163860321, -0.12935587763786316, -0.03224886208772659, -0.32219523191452026, 0.2922784686088562, 0.13104593753814697, 1.064559817314148, -0.5371442437171936, 0.18738843500614166, 0.023219754919409752, -0.12885920703411102, -0.13441738486289978, 0.1725093573331833, 0.48462244868278503, -0.27792996168136597, -0.5166923403739929, -0.23544827103614807, -0.3857690393924713, -0.08994801342487335, -0.32670438289642334, -0.6116938591003418, -0.8395593166351318, 0.13137294352054596, 0.33357149362564087, -0.6054041981697083, -0.037929683923721313, -0.716090977191925, -0.4677312970161438, 0.19093738496303558, -0.08437607437372208, -0.019053131341934204, 0.6011004447937012, -0.08195564150810242, 0.1640532910823822, 0.24586988985538483, 0.14924322068691254, -0.019850237295031548, -0.10591891407966614, 0.39165347814559937, 0.2705628573894501, 0.030812865123152733, 0.09642166644334793, 0.41448867321014404, 0.24377191066741943, -0.13803455233573914, -0.19573727250099182, -0.37178394198417664, 0.5359392762184143, -0.17903222143650055, 0.10438322275876999, -0.12304553389549255, 0.1785162389278412, -0.286307692527771, -0.09256993234157562, -0.24082164466381073, -0.8791359066963196, -0.41446003317832947, -0.3576028048992157, -0.13919377326965332, 0.5220345854759216, 0.11577389389276505, 0.12773384153842926, 0.13608188927173615, -0.2573454976081848, 0.11097817867994308, -0.04610336571931839, 0.0018083987524732947, 0.34295597672462463, -0.24547985196113586, 1.398422122001648, -0.40837201476097107, -0.3264612555503845, 1.4499567747116089, 0.5102819204330444, 0.12554043531417847, -0.15391913056373596, -0.6748878955841064, 0.6964665055274963, -0.07448074966669083, -0.3589787781238556, 0.2548810541629791, -0.18214304745197296, 0.32059264183044434, -0.22169847786426544, -0.024262841790914536, 0.3394886255264282, -0.3933125138282776, 0.24729633331298828, -0.46138378977775574, 0.3263736665248871, -0.6262794137001038, -0.15801827609539032, 0.16204147040843964, -0.45975199341773987, 0.2729640603065491, 0.7534365057945251, -0.4245798885822296, 0.3289915919303894, 0.9796076416969299, -0.4188733398914337, 0.49866533279418945, 0.5705661773681641, 0.20983929932117462, 0.6661325693130493, -0.08499503135681152, 0.3471648395061493, -0.8264658451080322, 0.08197203278541565, -0.25592610239982605, -0.03243342414498329, 0.2182169258594513, 0.37521108984947205, -0.07228824496269226, 0.09366714954376221, -0.5640397667884827, 0.16838718950748444, 0.893570601940155, -0.6141296625137329, -0.1989389955997467, 0.29893025755882263, -0.06020990386605263, 0.1011180728673935, 0.1077493280172348, -0.7761897444725037, 0.14803078770637512, 0.11977612972259521, 0.05524391680955887, 0.1558777093887329, -0.3544555604457855, 0.6221645474433899, -0.01997707411646843, 0.09284207969903946, 0.12406723946332932, 0.10722408443689346, 0.022193940356373787, 0.2786329388618469, -0.3373624086380005, -0.12350747734308243, 0.11770852655172348, 0.11577612161636353, -0.15246538817882538, -0.3824375569820404, -0.33395862579345703, 1.4173665046691895, 0.31025415658950806, 1.1623718738555908, -0.02121669612824917, -0.8181858658790588, -0.11233403533697128, -0.23058685660362244, -0.22563281655311584, 0.05115630105137825, 0.8363082408905029, -0.27924251556396484, -0.040007997304201126, -0.2652961015701294, -0.333894819021225, 0.6528208255767822, 0.25988301634788513, -0.181754007935524, -0.38506177067756653, -0.1713140457868576, -0.5903159976005554, -0.7762020230293274, -0.5962864756584167, -0.05049366131424904, 0.1791205108165741, 0.020876212045550346, -0.018440794199705124, -0.08961842209100723, 0.37372592091560364, 0.017337750643491745, 0.6710072755813599, 0.8479465842247009, -0.44117116928100586, 0.39432185888290405, 0.39103835821151733, -0.3498633801937103, -0.07874990254640579, -0.11024145781993866, 0.19831079244613647, -0.2345845252275467, -0.024985527619719505, -5.587315559387207, 0.14669375121593475, 0.047454312443733215, -0.13712160289287567, 0.18482519686222076, -0.5695425868034363, 1.029454231262207, 0.15427754819393158, 0.5449432134628296, 0.12093912065029144, 0.14880168437957764, 0.33028486371040344, -0.02932484820485115, -0.09641263633966446, -0.22608838975429535, 0.1500765085220337, -0.19427990913391113, 0.05180928483605385, 0.7056534290313721, 0.06063894182443619, -0.14663802087306976, -0.052495233714580536, -0.010674082674086094, 0.5338112711906433, -0.15616554021835327, -0.36625170707702637, -0.5966697931289673, -0.17511676251888275, -0.2718420624732971, 0.12362806499004364, 0.20059236884117126, -0.7564160823822021, 0.07584816962480545, -0.14963042736053467, 0.3364604413509369, -0.6375657320022583, 0.32181015610694885, -0.14157110452651978, -0.08211763948202133, -0.6667804718017578, 0.10524891316890717, 0.7158634066581726, -0.2523730397224426, -0.054764166474342346, 0.4465252161026001, -0.5468537211418152, -0.3688562214374542, -0.08698553591966629, -0.4737075865268707, 0.8578218817710876, -0.3155173361301422, -0.09396287053823471, 0.17523115873336792, 0.427168071269989, 0.7327818870544434, 0.3800695538520813, -0.2545509934425354, -0.04376987740397453, -0.6826788187026978, 0.18541613221168518, -0.6194491982460022, -0.23163820803165436, -0.6986766457557678, -0.160160094499588, -0.09280995279550552, 0.21355293691158295, -0.6618154048919678, -0.600091814994812, 0.4400983154773712, -0.47000589966773987, -0.2893170416355133, 0.25366178154945374, 0.3550727665424347, -0.7137330770492554, 0.6301718354225159, -0.045982349663972855, 0.08795065432786942, 0.08633219450712204, -0.07811441272497177, 0.06740391999483109, -0.5597695112228394, -0.17346516251564026, -0.33170923590660095, 0.1235327199101448, -0.2921525835990906, -0.1142699345946312, 0.21092233061790466, -0.012522304430603981, -0.22708870470523834, 0.2650678753852844, 0.5571756958961487, -0.5366985201835632, -0.020851917564868927, 0.33203771710395813, -0.3053911030292511, 0.37638047337532043, 0.0341118723154068, 0.8009412884712219, 0.5411750674247742, 0.21561291813850403, 1.2418311834335327, -0.08319602906703949, -0.45291492342948914, -0.6992381811141968, 0.1801486611366272, -0.009283318184316158, -0.07232433557510376, 0.32950836420059204, 1.1768161058425903, -0.7202228903770447, 0.15672484040260315, 0.25916844606399536, -0.663123369216919, -0.3450067341327667, 0.9498632550239563, -0.6291205286979675, -0.22538162767887115, 0.2859016954898834, 0.4543479382991791, -0.14884662628173828, 0.0011781837092712522, 0.459296315908432, -0.5477091073989868, 0.20732632279396057, -0.45061537623405457, 0.4360770881175995, -0.17010658979415894, 0.02923954278230667, -0.744584858417511, -0.08928115665912628, 0.25170785188674927, 0.28581953048706055, -0.19276276230812073, 0.10947886854410172, 0.24448685348033905, -0.40614768862724304, -0.19573573768138885, 0.0788016989827156, 0.42063623666763306, -0.6465432643890381, 0.4082065522670746, 0.03672638535499573, -0.08728118985891342, -0.22646796703338623, 0.43375709652900696, 0.2904652953147888, -0.3800962269306183, 0.19596141576766968, -0.5473137497901917, -0.20832154154777527, 0.20139558613300323, -0.345559298992157, -0.4000587463378906, 0.2206590175628662, -0.1283687949180603, 0.7049927711486816, 0.44229820370674133, 0.20730628073215485, 0.1394675076007843, -0.42425310611724854, 0.18120905756950378, 0.4557197690010071, -0.905470609664917, -0.0027586771175265312, 0.25241002440452576, -0.3791927993297577, 0.19322499632835388, -0.7775747179985046, -0.12427132576704025, 0.15508608520030975, -0.4907516837120056, 0.2113627940416336, 0.36461129784584045, -0.19153104722499847, -0.18660196661949158, -0.28183144330978394, -0.5169705152511597, 0.26251256465911865, -0.38237282633781433, 0.4764189124107361, 0.1983174979686737, -0.36827901005744934, -0.5128148794174194, 0.19960814714431763, 0.1400241255760193, 0.08375300467014313, -0.01360965333878994, -0.33391186594963074, 0.1569017618894577, -0.6325134038925171, 0.23801328241825104, 0.14206019043922424, -0.30339592695236206, -0.22218966484069824, 0.29317161440849304, 0.1976945847272873, 0.07447952777147293, 0.08755629509687424, -0.10001423209905624, -0.6299993395805359, -0.00034279676037840545, 0.5543569922447205, -0.3328064978122711, 0.1701658070087433, 0.05639544129371643, 0.5478202700614929, 0.3040868639945984, 0.33209988474845886, -0.0008585196337662637, -0.2371983379125595, 0.03878890350461006, -0.7186703681945801, 0.17464643716812134, 0.11260800808668137, 0.17322798073291779, 0.09080402553081512, -0.023698769509792328, -0.4312100410461426, -0.36046579480171204, 0.17877286672592163, 0.07346721738576889, 0.03402906283736229, 0.325259804725647, -0.14712713658809662, -0.23219014704227448, 0.24118420481681824, 0.0877966359257698, -0.6824010610580444, 0.5194380879402161, 0.2582637071609497, 0.2613039016723633, -0.10602939128875732, 0.3178812861442566, 0.6557819247245789, -0.4994325339794159, -0.5592690706253052, -0.6347836852073669, -0.15911069512367249, 0.08002093434333801, 0.7673032879829407, 0.45877930521965027, 0.11261016875505447, -0.7686867713928223, -0.2448556125164032, 0.0865931436419487, 0.5897732973098755, 0.29694753885269165, -0.38967764377593994, -0.4139150381088257, 0.05381205305457115, 0.30748450756073, -0.13581369817256927, -0.29587653279304504, 0.5222505927085876, 0.6908048391342163, -0.4555673897266388, 0.2573387920856476, 0.04412894695997238, -0.5225874185562134, 0.057030607014894485, -0.5636863112449646, 0.10109718143939972, 0.1924312859773636, 0.3971002995967865, 0.23593634366989136, -0.057317670434713364, -0.133180633187294, -0.9914097785949707, 0.3460302948951721, -0.18617741763591766, -0.42425861954689026, 0.1601322740316391, 1.039395809173584, -0.13335834443569183, -0.5201741456985474, 0.6190541386604309, -0.23850201070308685, 0.5439652800559998, -0.3470865488052368, 0.2532366216182709, -0.27255067229270935, -0.782545804977417, 0.4937410056591034, -0.3309049904346466, 0.15316174924373627, -0.6042253971099854, 0.1511795073747635, -0.2952268719673157, -0.08961586654186249, 0.053360164165496826, -0.0416187047958374, -0.3228510618209839, -0.8536921143531799, -0.5708810687065125, 0.13612285256385803, 0.14508037269115448, -0.027403444051742554, 0.2165064960718155, -0.0804324820637703, 0.588094174861908, -0.9315422773361206, 0.4117238223552704, 0.4779505431652069, -0.34978312253952026, -0.3311258554458618, 0.2588143050670624, 0.3392050862312317, 0.2058398723602295, -0.4765239953994751, -0.11138668656349182, -0.201398566365242, -0.2792789340019226, 0.6330385208129883, 0.06190774589776993, -0.4129548668861389, 0.628669798374176, 0.300896555185318, -0.14647848904132843, 0.011927415616810322, 0.1912590116262436, 0.08658941090106964, 0.22816582024097443, 0.019147604703903198, -0.007560742553323507, -0.5468307137489319, 0.7432921528816223, 0.27599993348121643, 0.3816980719566345, -0.020053021609783173, 0.7081092596054077, 0.577012836933136, -0.0952509194612503, -0.015753628686070442, 0.820547342300415, 0.4145621657371521, -0.3083720803260803, 0.5908343195915222, -0.8727369904518127, -0.19076494872570038, 0.27234509587287903, 0.7143037915229797, 0.9638521671295166, -0.23933221399784088, -0.3237049877643585, 0.3432023823261261, 0.3892779052257538, 0.08205688744783401, 0.37223395705223083, -0.16149260103702545, 0.4936619699001312, 0.472224622964859, -0.26215431094169617, -0.32275474071502686, 0.18709807097911835, -0.8551374673843384, 0.40107032656669617, 0.6421401500701904, -0.4754527807235718, -0.5755646228790283, 0.08095981180667877, -0.23416975140571594, 0.316242516040802, 0.16727757453918457, 0.8216210007667542, -0.3081901967525482, 0.11619645357131958, 0.7116401195526123, -0.18032680451869965, 0.24686233699321747, -0.015557218343019485, -0.06264723837375641, -0.16114677488803864, -0.09698876738548279, 0.016727155074477196, -0.0044085183180868626, 0.08111679553985596, 0.597526490688324, -0.24231381714344025, 0.10407137125730515, 0.88426673412323, -0.27918127179145813, 0.1492733210325241, -0.30014100670814514, -0.9815941452980042, -0.5535435080528259, -0.3097158670425415, -0.43368199467658997, -0.29794132709503174, -0.06180549040436745, -0.03372955694794655, 0.08975940942764282, -0.4080103933811188, 0.431823194026947, 0.19110599160194397, 0.2610260546207428, -0.1903480440378189, 0.18222908675670624, 0.49318113923072815, 0.3474964499473572, 0.6888837218284607, 0.1824042797088623, 0.41968753933906555, -0.018592022359371185, 0.001366728451102972, -0.34978386759757996, 0.4851733446121216, -0.03290652483701706, -0.29082000255584717, -0.6864442229270935, -0.5411013960838318, 1.4672784805297852, 0.831308126449585, -0.19275252521038055, -0.06700854748487473, 0.09871800988912582, 0.6476427316665649, 0.5226800441741943, -0.6136875152587891, -0.22397707402706146, -0.5845023989677429, -0.025068210437893867, -0.48393693566322327, 0.3150310814380646, 0.02724236436188221, -0.40330201387405396, 0.20865747332572937, 0.537689745426178, 0.11719423532485962, -0.39443692564964294, 0.333376944065094, -0.34925684332847595, -0.30716949701309204, -0.37090596556663513, 0.14397472143173218, -0.5325896739959717, 0.5251540541648865, -0.43846258521080017, 0.026942215859889984, 0.22105607390403748, 0.19202552735805511, 0.4434157907962799, 0.01705518737435341, -0.31083786487579346, -0.10424600541591644, 0.15225082635879517, 0.2058435082435608, -0.7999594807624817, -0.8536528944969177, -0.26222217082977295, -0.08775009959936142, 0.32442593574523926, -0.43785616755485535, 0.056966621428728104, 0.15864016115665436, -0.31710076332092285, -0.30781233310699463, 0.43593668937683105, -0.4320620596408844, -0.16600936651229858, 0.38892245292663574 ]
BackgroundIndividuals with substance use disorders (SUDs) are at increased risk for hepatitis C viral infection (HCV), and few studies have explored their treatment responses empirically. The objective of this study was to assess interferon alpha therapy (IFN) completion and response rates among patients with HCV who had a history of comorbid SUDs. More data is needed to inform treatment strategies and guidelines for these patients. Using a medical record database, information was retrospectively collected on 307,437 veterans seen in the Veterans Integrated Service Network 20 (VISN 20) of the Veterans Healthcare Administration (VHA) between 1998 and 2003. For patients treated with any type of IFN (including regular or pegylated IFN) or combination therapy (IFN and ribavirin) who had a known HCV genotype, IFN completion and response rates were compared among patients with a history of SUD (SUD+ Group) and patients without a history of SUD (SUD- Group).ResultsOdds ratio analyses revealed that compared with the SUD- Group, the SUD+ Group was equally likely to complete IFN therapy if they had genotypes 2 and 3 (73.1% vs. 68.0%), and if they had genotypes 1 and 4 (39.5% vs. 39.9%). Within the sample of all patients who began IFN therapy, the SUD- and SUD+ groups were similarly likely to achieve an end of treatment response (genotypes 2 and 3, 52.8% vs. 54.3%; genotypes 1 and 4, 24.5% vs. 24.8%) and a sustained viral response (genotypes 2 and 3, 42.6% vs. 41.1%; genotypes 1 and 4: 16.0% vs. 22.3%).ConclusionIndividuals with and without a history of SUD responded to antiviral therapy for HCV at similar rates. Collectively, these findings suggest that patients who have co-morbid SUD and HCV diagnoses can successfully complete a course of antiviral therapy.
[ -0.01721796579658985, 0.0024157564621418715, -0.012515599839389324, 0.020138489082455635, 0.0023607974871993065, -0.00007775239646434784, 0.009232301265001297, 0.00616946816444397, -0.013014414347708225, -0.018166694790124893, 0.004631654359400272, 0.011540479026734829, -0.015910807996988297, 0.02498963102698326, -0.019358955323696136, 0.008304730989038944, -0.02138703316450119, -0.002660993719473481, 0.008602685295045376, -0.010795310139656067, 0.025623049587011337, 0.006023416295647621, 0.0102364681661129, -0.0075620198622345924, -0.036738865077495575, 0.012364954687654972, 0.01611301675438881, -0.006494492758065462, 0.005247946362942457, -0.027950214222073555, 0.009478346444666386, -0.011318073607981205, -0.008420919999480247, 0.030394870787858963, 0.003141197608783841, -0.015580041334033012, -0.00631891842931509, 0.02250613272190094, 0.009884998202323914, -0.00543097173795104, -0.027657784521579742, -0.009998180903494358, 0.00823228806257248, -0.0037044307682663202, -0.0063276286236941814, -0.012470534071326256, -0.009755322709679604, 0.02112240344285965, 0.028533311560750008, 0.013584522530436516, -0.00039652385748922825, -0.011974557302892208, -0.012738868594169617, -0.020412495359778404, -0.005960055626928806, -0.02427464723587036, 0.019424373283982277, 0.00787465088069439, -0.02423989772796631, -0.0044618817046284676, -0.023759808391332626, -0.007652269676327705, -0.003235940122976899, -0.009192158468067646, 0.00758973928168416, -0.06665787845849991, -0.0037577124312520027, 0.01574275828897953, 0.018837157636880875, 0.02347859926521778, 0.001324986107647419, 0.006713767070323229, 0.014817514456808567, 0.005640816409140825, -0.016278168186545372, 0.005470167845487595, 0.019717466086149216, 0.004470546264201403, 0.009419993497431278, -0.028695421293377876, 0.003965131938457489, 0.006066480185836554, 0.007939791306853294, 0.014270240440964699, 0.023852143436670303, -0.016238149255514145, -0.019830981269478798, -0.02514035813510418, 0.029226908460259438, -0.03215290978550911, 0.0062165772542357445, -0.006173836532980204, -0.025414226576685905, 0.018120333552360535, -0.041548654437065125, -0.039984963834285736, 0.0021042381413280964, -0.026519015431404114, -0.017055541276931763, -0.017551688477396965, -0.011141395196318626, -0.008396260440349579, 0.02265399694442749, 0.01897275261580944, -0.016852345317602158, 0.005368536803871393, -0.015457302331924438, -0.002036977792158723, -0.009037002921104431, 0.01059824787080288, 0.014885404147207737, -0.003353740554302931, 0.03838753700256348, -0.004194831941276789, 0.01807244122028351, 0.01826505735516548, 0.008700969628989697, 0.0027936268597841263, 0.010844195261597633, -0.015406602062284946, -0.005729460623115301, -0.015326665714383125, -0.000055104464991018176, 0.005623338744044304, 0.0007929765270091593, 0.016894634813070297, -0.008754217997193336, 0.0010360479354858398, -0.008786316961050034, -0.014690075069665909, -0.006039773114025593, -0.0005169282667338848, -0.00469397334381938, -0.009422333911061287, 0.007900201715528965, 0.004349583759903908, 0.013742807321250439, -0.010875746607780457, -0.010137943550944328, -0.010125811211764812, -0.022129537537693977, 0.005612180568277836, -0.007176474668085575, 0.009792457334697247, -0.04067306965589523, -0.007990706712007523, -0.011539510451257229, -0.007193064317107201, 0.00903547927737236, -0.00457827840000391, -0.006944685708731413, 0.0035146158188581467, -0.019068259745836258, -0.018629461526870728, -0.025794383138418198, -0.020912688225507736, -0.003418002277612686, -0.0158989354968071, 0.0003898128343280405, 0.0011663808254525065, 0.01263679563999176, -0.02722560055553913, 0.023583833128213882, 0.009260313585400581, 0.01293706800788641, 0.045198675245046616, 0.01412181742489338, 0.007264124229550362, -0.0019021453335881233, 0.0067202253267169, 0.002222807612270117, 0.013416578993201256, -0.01458461582660675, 0.010061502456665039, 0.01209238637238741, -0.015092285349965096, 0.0036476515233516693, 0.005177191458642483, -0.011900505051016808, 0.06577868014574051, 0.0024876873940229416, 0.016717325896024704, -0.027884334325790405, 0.0014588064514100552, -0.0038929933216422796, -0.019808024168014526, 0.011681035161018372, -0.014733448624610901, 0.005220790393650532, -0.02414614148437977, -0.021639887243509293, -0.005622733384370804, -0.006924082525074482, -0.0024097778368741274, 0.008663266897201538, 0.003523256629705429, 0.026045622304081917, 0.010497813113033772, 0.006473415531218052, 0.039936598390340805, 0.017810920253396034, 0.006208170671015978, 0.010156129486858845, -0.0025996658951044083, -0.053316809237003326, 0.006251692771911621, 0.02142341062426567, 0.0013332313392311335, 0.0026481258682906628, -0.004625016823410988, 0.036571621894836426, -0.00022335280664265156, 0.003932620398700237, -0.004103351384401321, 0.01602824032306671, -0.005595045164227486, -0.013273652642965317, -0.0005400022491812706, -0.03601779043674469, -0.017536859959363937, 0.0014676861464977264, 0.010706034488976002, -0.007293820846825838, -0.0001475336030125618, -0.007446874398738146, 0.006496051326394081, -0.010761478915810585, 0.008290056139230728, -0.006085735745728016, 0.0032751020044088364, -0.0015126604121178389, -0.0034758830443024635, -0.011674487963318825, -0.011825261637568474, 0.01865091174840927, 0.02002578042447567, 0.014661423861980438, -0.009755661711096764, 0.011032862588763237, -0.021471116691827774, -0.022959858179092407, -0.007287141401320696, 0.02944059856235981, -0.010186848230659962, 0.008375853300094604, -0.008157119154930115, -0.0002531405771151185, -0.009608667343854904, 0.008527731522917747, -0.017275650054216385, 0.0063608367927372456, 0.02990090101957321, 0.003509505884721875, -0.015593152493238449, 0.01327589713037014, -0.022510778158903122, 0.02464079111814499, 0.012497451156377792, 0.026245728135108948, 0.010460296645760536, 0.009687598794698715, 0.00459986412897706, -0.003924835007637739, -0.016691498458385468, 0.018947113305330276, -0.01469755731523037, -0.026230230927467346, -0.0035146691370755434, 0.028796136379241943, -0.006339295767247677, 0.008735733106732368, -0.008756344206631184, -0.01563872955739498, -0.08167044818401337, -0.007418022025376558, 0.0006219602655619383, 0.0125518087297678, 0.010189126245677471, 0.003919433802366257, -0.020489821210503578, -0.0017573835793882608, 0.0013190658064559102, 0.0020437920466065407, -0.006532096303999424, 0.04053175449371338, -0.007022939622402191, 0.02298005297780037, 0.022283632308244705, -0.008317980915307999, -0.0038617076352238655, -0.0035488237626850605, -0.03289599344134331, -0.020924990996718407, 0.0006400865968316793, 0.012631063349545002, 0.03344608098268509, 0.015451917424798012, 0.018594922497868538, 0.036583997309207916, -0.00959482230246067, -0.008609293028712273, -0.018252957612276077, -0.006450904533267021, 0.012660307809710503, -0.013859396800398827, 0.013487039133906364, 0.01439934503287077, -0.007612062618136406, -0.031152483075857162, -0.02104252576828003, -0.009252695366740227, 0.005298062693327665, -0.0045849718153476715, -0.009988768957555294, 0.007584708277136087, 0.022009141743183136, 0.006554897408932447, 0.01129140891134739, -0.023015839979052544, 0.024965327233076096, 0.017406826838850975, 0.016220320016145706, -0.004935747012495995, -0.024162517860531807, -0.01305975392460823, 0.011336656287312508, 0.014360606670379639, -0.010677466168999672, -0.029148470610380173, -0.0194449070841074, 0.016919419169425964, -0.01319835614413023, -0.01956605166196823, -0.026159394532442093, -0.027612248435616493, 0.006431137211620808, 0.004154783673584461, 0.0027325237169861794, 0.00028322520665824413, 0.014211058616638184, 0.018287528306245804, -0.0071348631754517555, 0.02401028946042061, -0.015089863911271095, 0.0014296593144536018, -0.010747998021543026, -0.008374039083719254, 0.0068911341950297356, 0.0015945150516927242, -0.022034309804439545, 0.008706077933311462, -0.01988287642598152, -0.018165478482842445, -0.02043815888464451, 0.004750636871904135, 0.0012040820438414812, -0.005812827963382006, 0.0002844866830855608, 0.027837160974740982, 0.014945906586945057, 0.015346941538155079, 0.011478642001748085, -0.01578408107161522, -0.0006982726044952869, -0.010157398879528046, -0.007904451340436935, 0.008361972868442535, 0.0005642047617584467, -0.025057531893253326, -0.0054487488232553005, 0.008136987686157227, -0.00013591628521680832, 0.00766560435295105, -0.026003321632742882, -0.016515543684363365, -0.026474352926015854, -0.009494831785559654, -0.005038841627538204, 0.02131481096148491, -0.0018660181667655706, 0.005157954525202513, 0.0036005782894790173, -0.009812035597860813, 0.006743927951902151, -0.012813583016395569, -0.0020792242139577866, 0.029391232877969742, 0.015102285891771317, 0.006988645996898413, 0.029150454327464104, -0.005002359859645367, 0.07235382497310638, 0.022383147850632668, -0.002442200668156147, 0.010634387843310833, 0.02008454129099846, -0.0035930508747696877, -0.02766290307044983, -0.0006061433814466, -0.0024950942024588585, -0.025770703330636024, 0.013135015033185482, -0.011571967974305153, -0.01656072400510311, -0.02542467787861824, 0.004554379731416702, 0.009952794760465622, -0.010483842343091965, -0.03346080332994461, -0.0018877815455198288, 0.007698703557252884, -0.0047539398074150085, 0.015372034162282944, 0.003229969646781683, -0.016883011907339096, 0.01433558203279972, -0.02505907230079174, -0.0015121633186936378, -0.010118691250681877, -0.025018705055117607, 0.009916664101183414, 0.0028876252472400665, 0.01788068190217018, -0.006570328492671251, -0.01671857200562954, 0.006072948686778545, 0.0005324799567461014, 0.002377290977165103, 0.006470362190157175, -0.004921152722090483, -0.009988810867071152, -0.012633591890335083, -0.01768983155488968, -0.013744443655014038, 0.010209983214735985, 0.014476574957370758, 0.006498725153505802, 0.01575007103383541, -0.007461278699338436, -0.009512510150671005, 0.003861039411276579, -0.01751982606947422, -0.009790324606001377, 0.013522760942578316, -0.00421197060495615, 0.009474420920014381, -0.0006592483259737492, -0.004924636334180832, 0.00621204636991024, 0.000867371098138392, -0.02524738386273384, -0.008906621485948563, -0.03140160068869591, 0.0018343147821724415, 0.021604212000966072, -0.0012760251993313432, -0.0029384419322013855, 0.011273998767137527, -0.005588878877460957, -0.00424784142524004, -0.013071106746792793, -0.02624358981847763, -0.02314610779285431, 0.0016289593186229467, -0.008392369374632835, -0.029386848211288452, -0.004191521555185318, 0.008507205173373222, -0.005691543687134981, 0.023967213928699493, -0.0137611860409379, -0.010091337375342846, 0.005681527312844992, 0.023752354085445404, -0.023380519822239876, 0.003333966713398695, 0.03755418211221695, -0.04930075630545616, -0.07487312704324722, -0.030501874163746834, -0.02068481594324112, -0.012603988870978355, 0.016623010858893394, -0.013328617438673973, -0.021268481388688087, -0.014449911192059517, -0.026504425331950188, -0.009990690276026726, -0.021871576085686684, -0.030721254646778107, -0.002191339386627078, 0.008459704928100109, 0.011674392968416214, 0.001926872879266739, -0.017939304932951927, -0.008792649954557419, -0.027415813878178596, 0.029270462691783905, -0.012966305948793888, 0.01790102943778038, -0.032537102699279785, -0.008908146061003208, -0.0019177759531885386, -0.08116655796766281, 0.003080526599660516, 0.0010393713600933552, -0.03063010424375534, 0.008908010087907314, -0.019594766199588776, 0.013987237587571144, -0.0013716922840103507, 0.014038927853107452, -0.015817977488040924, 0.003014833200722933, -0.008794505149126053, -0.010845998302102089, -0.007275029551237822, -0.01847684569656849, -0.0077226306311786175, -0.003828564193099737, 0.040798936039209366, -0.008227577432990074, 0.005962649825960398, 0.014805052429437637, 0.010869322344660759, -0.0027473377995193005, 0.00728492671623826, -0.011448012664914131, -0.01578093320131302, -0.00039856869261711836, 0.0138088995590806, -0.008925186470150948, -0.041680920869112015, 0.01884182170033455, 0.015474103391170502, -0.0031123002991080284, -0.008845426142215729, 0.023144779726862907, -0.01773633435368538, 0.01565898209810257, 0.016306040808558464, 0.027450785040855408, 0.006803870666772127, -0.0036578672006726265, -0.03528150916099548, 0.007814216427505016, 0.002538746688514948, 0.0226595476269722, -0.025343652814626694, 0.006916062906384468, -0.018579009920358658, 0.007702369708567858, -0.017513785511255264, 0.001345065189525485, 0.005832943599671125, 0.018554717302322388, 0.01629682630300522, -0.013300025835633278, -0.008490098640322685, -0.016625739634037018, 0.03318897634744644, -0.01619374193251133, -0.004162570461630821, -0.001388300210237503, 0.004154243040829897, -0.025509145110845566, 0.07088381052017212, -0.005327373743057251, -0.007305399514734745, -0.015607530251145363, -0.008701055310666561, -0.00000216066837310791, -0.0219369325786829, -0.021319305524230003, -0.0030547799542546272, -0.01708132214844227, -0.02316872961819172, -0.012406622990965843, 0.0016849336680024862, 0.013215674087405205, -0.00286049279384315, -0.012004448100924492, -0.01850810833275318, 0.003965336829423904, -0.017348874360322952, -0.0008188867941498756, -0.001440456137061119, 0.0018255701288580894, 0.014230672270059586, -0.008569708094000816, 0.008567060343921185, -0.009548614732921124, 0.0031867381185293198, 0.00011845724657177925, -0.0012338283704593778, 0.019236382097005844, -0.011637788265943527, 0.008415084332227707, 0.010553745552897453, 0.018477607518434525, -0.005291840061545372, -0.018812943249940872, 0.006705923937261105, 0.010794193483889103, -0.01990363374352455, 0.0024206244852393866, -0.02390344813466072, -0.013155300170183182, 0.0010674099903553724, -0.041680626571178436, 0.023398492485284805, -0.006383759900927544, 0.007541010156273842, -0.006805239710956812, -0.014450760558247566, 0.021322457119822502, 0.0012665486428886652, 0.004914280027151108, 0.015046551823616028, -0.015691235661506653, 0.0004899026243947446, 0.007070191204547882, -0.02423357404768467, 0.020410653203725815, 0.0042788200080394745, -0.0013907328248023987, -0.02043904736638069, -0.01655767671763897, -0.005443006753921509, -0.01854650117456913, 0.04034768044948578, -0.0133450236171484, 0.03704529628157616, -0.01867499016225338, -0.041874565184116364, 0.012247985228896141, -0.004603926092386246, 0.0009033213718794286, 0.008714824914932251, -0.00005321390926837921, -0.00048182345926761627, -0.006064510904252529, 0.041438028216362, 0.0011199112050235271, 0.023165099322795868, 0.021377887576818466, 0.0010122947860509157, -0.021946284919977188, 0.008926758542656898, 0.004748936276882887, -0.014949658885598183, -0.025564081966876984, 0.0013121915981173515, -0.008225835859775543, -0.010446636937558651, 0.004774296656250954, 0.0035843513906002045, 0.0025062006898224354, -0.0026996792294085026, 0.0364655964076519, 0.008650671690702438, 0.03465377166867256, -0.02636297419667244, -0.0027643260546028614, 0.006415544543415308, 0.008475221693515778, 0.039164625108242035, 0.009943726472556591, -0.013331212103366852, 0.014614559710025787, 0.009809974581003189, 0.0024321654345840216, 0.00230141612701118, -0.012180531397461891, 0.036336418241262436, -0.0028884061612188816, 0.007600783836096525, -0.008592937141656876, 0.03988227620720863, 0.023485705256462097, -0.0006504412740468979, 0.023381926119327545, -0.0077950432896614075, -0.01384802907705307, -0.013472852297127247, -0.013696224428713322, -0.009284647181630135, 0.004461403004825115, 0.02698839083313942, 0.009872090071439743, -0.026979269459843636, -0.015573931857943535, -0.0057040550746023655, -0.021702982485294342, 0.005573526956140995, 0.013969618827104568, 0.019853180274367332, 0.02719518356025219, -0.013828645460307598, 0.005179517436772585, 0.010163838975131512, -0.023653952404856682, 0.00824550911784172, 0.006481935735791922, -0.018850052729249, -0.004273894242942333, 0.020046696066856384, 0.006269126199185848, 0.0019049649126827717, -0.0006098891608417034, 0.009513325057923794, 0.012156333774328232, -0.007177313789725304, 0.007538670673966408, 0.011326979845762253, 0.010612959042191505, -0.008686855435371399, -0.011693285778164864, 0.0008931206539273262, -0.00491653848439455, -0.00694494741037488, 0.016075562685728073, 0.011950020678341389, 0.012343905866146088, -0.010295802727341652, -0.013014496304094791, 0.007145408540964127, -0.03268297761678696, -0.019561776891350746, -0.0018249524291604757, -0.0019993723835796118, 0.026826929301023483, -0.015889592468738556, -0.003940750379115343, 0.009143229573965073, 0.0060662440955638885, 0.019839441403746605, 0.010019020177423954, -0.000533238984644413, 0.02505303919315338, -0.04232781380414963, -0.006219526287168264, -0.012899203225970268, 0.03265436738729477, -0.031180676072835922, 0.028670692816376686, -0.013037597760558128, -0.01223778072744608, -0.009804408065974712, -0.009289124049246311, 0.013413364067673683, -0.006779640447348356, -0.017984561622142792, 0.010327278636395931, -0.0020403508096933365, 0.03186316788196564, -0.026150621473789215, 0.008916664868593216, -0.01940549910068512, -0.014253736473619938, -0.00047929014544934034, 0.016916118562221527, -0.006044237408787012, 0.015069412998855114, -0.006945365108549595, 0.001840708777308464, -0.008597644977271557, -0.02634028159081936 ]
[ 0.1305709183216095, -0.06813792139291763, -0.005151320248842239, 0.03217029199004173, -0.29472291469573975, 0.2700805962085724, 0.6146090030670166, 0.13226382434368134, -0.6064496636390686, -0.329719603061676, 0.11106596142053604, 0.5013455152511597, -0.059058018028736115, -0.23259302973747253, 0.05548607185482979, 0.6764395236968994, 0.4624234139919281, 0.21421802043914795, -0.06800111383199692, -0.682418167591095, -0.3288280665874481, -0.5346618294715881, 0.10968687385320663, -0.14500021934509277, 0.30068308115005493, 0.4066435396671295, 0.1349249929189682, -0.006811628583818674, -0.25252091884613037, -0.2758353054523468, -0.09532494097948074, 0.5670400261878967, 0.09675738960504532, -0.16974221169948578, -0.20548109710216522, 0.06463019549846649, -0.028139624744653702, -0.07097318023443222, 0.3414485454559326, -0.17845496535301208, -0.21403361856937408, -0.5243736505508423, -0.14860042929649353, 0.32613444328308105, -0.1658734381198883, -0.5236179232597351, -0.9286820292472839, 0.4738731384277344, -0.11743032932281494, 0.025401506572961807, 0.17842601239681244, 0.4376738965511322, 0.09171818196773529, 0.28468698263168335, 0.1609129011631012, -0.18039105832576752, -0.350050687789917, -0.12357288599014282, 0.26927104592323303, -0.35676270723342896, -0.06867877393960953, 0.15317977964878082, -0.003035859204828739, 0.09092554450035095, -0.22110845148563385, 0.4371514618396759, 0.23001807928085327, 0.373169869184494, -0.24972355365753174, -0.22429537773132324, 0.32051143050193787, -0.3902336061000824, 0.053710728883743286, -0.04633394256234169, -0.12011057138442993, -0.01640854775905609, 0.14535756409168243, -0.07208257168531418, 0.15265406668186188, -0.2762225866317749, 0.1208975613117218, 0.15077941119670868, 0.5606108903884888, -0.3212839961051941, 0.579317033290863, 0.35111212730407715, -0.08620630949735641, 0.47165173292160034, 0.2492062747478485, -0.36471688747406006, -0.10303931683301926, 0.14925597608089447, 0.5240516662597656, 0.414758563041687, 0.03355317562818527, 0.685736358165741, 0.13271667063236237, -0.0891333669424057, 0.39697134494781494, -0.020103245973587036, -0.13660970330238342, 0.11534276604652405, 0.26632681488990784, -0.11482343077659607, -0.4765993654727936, -0.048007603734731674, 0.22540956735610962, -0.23839831352233887, -0.8441174030303955, 0.5509718060493469, -0.7463558316230774, 0.1691051423549652, -0.0668167844414711, -0.4177859127521515, -0.22839675843715668, -0.022000929340720177, 0.25862520933151245, -0.17824967205524445, 0.16808465123176575, 0.383152037858963, -0.23044218122959137, 0.6862769722938538, -0.2886353135108948, 0.3457444906234741, -0.11380334943532944, 0.2356393039226532, 0.4034944772720337, 0.30121371150016785, -0.10910164564847946, 0.5564733147621155, 0.28541019558906555, 0.6508828997612, -0.24033576250076294, 0.5894895195960999, 0.1184982880949974, -0.26286327838897705, 0.10787468403577805, 0.448647677898407, 0.07446667551994324, 0.03751920908689499, -0.6608414649963379, -0.46398451924324036, -0.2660180628299713, -0.3351701498031616, -0.04164803400635719, -0.5436642169952393, 0.18128980696201324, 0.19184890389442444, 0.004838781431317329, -0.2726640999317169, 0.1692810207605362, -0.42849522829055786, -0.1268860548734665, -0.6017151474952698, 0.047789521515369415, 0.4505343437194824, -0.21133239567279816, -0.11896904557943344, -0.202262282371521, 0.056821711361408234, 0.34413111209869385, 0.334818959236145, -0.5245413780212402, -0.005572202615439892, 0.5171945691108704, -0.0015997806331142783, -0.7575680613517761, -0.23867332935333252, -0.03279168903827667, 0.12578199803829193, -0.144941508769989, -0.25993263721466064, -0.19878099858760834, -0.6093105673789978, 0.03926779702305794, 0.25409141182899475, 0.25607022643089294, 0.31883829832077026, 0.1802290380001068, -0.12678185105323792, -0.5335254669189453, 0.06971097737550735, 0.18017072975635529, -0.6600939631462097, 0.2396470159292221, 0.14403589069843292, 0.24969767034053802, 0.04768063500523567, 0.14855262637138367, -0.1448538601398468, -0.3541112542152405, -0.4617488980293274, 0.40195924043655396, -0.6416342258453369, 1.297534704208374, -0.3199203610420227, -0.026181522756814957, 1.2083280086517334, 0.2601466774940491, 0.023968251422047615, 0.24543766677379608, -0.030644409358501434, 0.891402542591095, -0.14319585263729095, -0.7908369302749634, 0.38214999437332153, 0.14048191905021667, 0.05627661198377609, -0.1855655461549759, 0.05378220975399017, 0.26633721590042114, -0.028227128088474274, -0.5916237235069275, 0.17599523067474365, -0.17026880383491516, 0.3825622498989105, -0.2197037637233734, 0.25547119975090027, 0.18860137462615967, -0.342813104391098, 0.6812435388565063, -0.8703779578208923, 0.6116986870765686, 0.32681289315223694, -0.4502231478691101, 0.536157488822937, 0.43748587369918823, -0.11926427483558655, 0.8633958697319031, -0.4131457507610321, 0.6121500730514526, 0.20864565670490265, 0.18418212234973907, -0.6085421442985535, -0.36070990562438965, -0.0988493263721466, -0.05409717559814453, -0.20337076485157013, 0.01604188047349453, -0.010511185973882675, -0.26441672444343567, 0.21912363171577454, -0.2908537685871124, -0.18384620547294617, -0.21463267505168915, -0.3163534998893738, -0.3333916962146759, 0.34503450989723206, -0.4483416974544525, 0.4434928297996521, 0.09447456896305084, 0.5125163793563843, -0.09496549516916275, -0.2890952527523041, 0.15739209949970245, 0.7760295867919922, 0.018979551270604134, -0.5293477177619934, 0.09913922846317291, -0.5792480707168579, 0.032725293189287186, 0.344837486743927, -0.02717491425573826, 0.3210509121417999, -0.10951920598745346, -0.6175553202629089, -0.45967623591423035, -0.05460058152675629, 0.7540310025215149, 0.5548955798149109, 0.4317813813686371, 0.2111010104417801, -0.4256230592727661, 0.21384473145008087, -0.24405613541603088, -0.4295041263103485, 0.21350760757923126, 0.8820568323135376, -0.5548135042190552, -0.5906149744987488, -0.20421844720840454, 0.14970552921295166, 0.7004720568656921, -0.001744377426803112, 0.23109577596187592, -0.5802551507949829, -0.20577119290828705, 0.07499270141124725, -0.40227851271629333, -0.24780981242656708, -0.169524684548378, 0.5527928471565247, -0.22293832898139954, -0.008966241031885147, 0.7720373272895813, 0.15603557229042053, 0.002340599661692977, 0.8447321653366089, 0.8303319215774536, 0.06397034972906113, 0.04355532303452492, 0.2997434735298157, 0.3782847225666046, -0.15117833018302917, -0.09364952892065048, 0.06418580561876297, -0.4580450654029846, -0.19664882123470306, -6.036177635192871, 0.6722748279571533, -0.3824862241744995, -0.386363685131073, -0.26650428771972656, 0.32242774963378906, 0.9037147760391235, -0.19767385721206665, 0.04377276822924614, 0.45196112990379333, -0.005561660975217819, 0.6871779561042786, 0.2581271529197693, 0.2972235381603241, -0.14431874454021454, 0.12175341695547104, 0.14535245299339294, -0.26083624362945557, 0.2644810974597931, 0.30479803681373596, -0.06580705940723419, -0.3030927777290344, -0.15371297299861908, 0.6116179823875427, 0.13278548419475555, 0.37785881757736206, -0.6807765364646912, 0.28738734126091003, 0.02989879436790943, -0.48780760169029236, 0.41265588998794556, -0.27070969343185425, -0.16074122488498688, 0.08219524472951889, 0.06467759609222412, -0.03175106644630432, 0.1767864227294922, 0.12062662839889526, -0.07657481729984283, -0.381318598985672, -0.10647941380739212, -0.04049086570739746, -0.1942058652639389, -0.13806258141994476, 0.33372247219085693, 0.49274107813835144, 0.11387866735458374, 0.13797521591186523, -0.07071495801210403, 0.8614434003829956, 0.07154680788516998, 0.03217434510588646, -0.147936150431633, 0.8554996252059937, 0.14604146778583527, -0.004583596717566252, -0.11030513048171997, 0.3871079683303833, -0.46807897090911865, 0.5180573463439941, 0.11466748267412186, 0.21598152816295624, -0.4361516535282135, -0.577035129070282, -0.2512529194355011, -0.03877156227827072, -0.8432170152664185, -0.43291687965393066, 0.2743311822414398, -0.05869419500231743, -0.14478811621665955, 0.0918780192732811, 0.34756791591644287, -0.6733855605125427, 0.597507894039154, -0.31087198853492737, 0.2077736258506775, 0.07854703068733215, -0.04594934359192848, -0.04386327788233757, 0.1392100304365158, -0.2000783383846283, 0.43424540758132935, -0.3785848319530487, -0.3964489996433258, 0.08942222595214844, 0.0010105767287313938, 0.37705880403518677, -0.01301633846014738, -0.1617107391357422, 0.3586025536060333, -0.13818359375, -0.03625176474452019, 0.23800495266914368, 0.07864166796207428, 0.7672853469848633, 0.631121814250946, 0.3426394462585449, 0.4556007385253906, -0.03628768399357796, 0.7897337675094604, -0.36781153082847595, -0.13575367629528046, -1.2775152921676636, -0.4317966103553772, -0.1424771547317505, -0.5046457052230835, -0.11625805497169495, 0.6349458694458008, -0.9428698420524597, 0.1983209103345871, -0.36387139558792114, -0.5102843642234802, -0.06933774799108505, 0.8529127240180969, -0.049499765038490295, 0.07853391766548157, 0.1526326835155487, 0.11588558554649353, 0.12713423371315002, 0.4003012776374817, 0.105190709233284, -0.40327903628349304, 0.35870975255966187, -0.22387681901454926, -0.4027131497859955, -0.03162577748298645, 0.4814625680446625, -1.1738951206207275, 0.09152738004922867, 0.15344570577144623, 0.3690907061100006, -0.4754400849342346, 0.09167874604463577, 0.12058740109205246, -0.4711594581604004, -0.5754083395004272, 0.3290424048900604, 0.785573422908783, 0.09564385563135147, 0.1454695761203766, -0.3437809348106384, -0.32247963547706604, 0.20444902777671814, 0.22195391356945038, -0.4607012867927551, -0.2543995678424835, -0.40593305230140686, -0.1323750764131546, -0.075464628636837, 0.1681189388036728, -0.12783361971378326, 0.2643113136291504, 0.13443022966384888, -0.4264240264892578, 0.11360449343919754, 0.2797974944114685, -0.10579545795917511, -0.03713987022638321, -0.7054777145385742, 0.4060513973236084, -0.005205274093896151, -1.2613673210144043, -0.44008371233940125, 0.21698151528835297, -0.7946365475654602, -0.18595698475837708, -0.6020322442054749, 0.21249809861183167, 0.36237403750419617, -0.06583015620708466, -0.4167146384716034, 0.03241066634654999, 0.11988136172294617, 0.12316066026687622, -0.20853079855442047, -0.2711494266986847, -0.15461885929107666, -0.13442005217075348, 0.2924240827560425, 0.11814004927873611, -0.308413565158844, -0.325957328081131, -0.07990272343158722, 0.575003445148468, 0.4975031614303589, 0.23477862775325775, -0.03761328384280205, -0.29612982273101807, -0.2860574424266815, 0.3999244272708893, -0.478699654340744, 0.31592923402786255, -0.2868775427341461, -0.34399503469467163, -0.24161513149738312, 0.17153052985668182, 0.32733163237571716, -0.34619206190109253, -0.04109532758593559, -0.26523786783218384, 0.24813765287399292, -0.1754133701324463, 0.3045653700828552, 0.39021846652030945, -0.528989315032959, -0.16314168274402618, -0.14363963901996613, -0.6571255922317505, -0.4617127478122711, -0.26110491156578064, -0.3122757375240326, -0.40721333026885986, 0.06745486706495285, -0.4331766366958618, 0.015880580991506577, -0.1074080690741539, -0.6106051802635193, -0.5983627438545227, 0.34091028571128845, -0.11811605095863342, 0.062238115817308426, -0.3356435298919678, 0.013149815611541271, -0.23292048275470734, 0.17458929121494293, 0.5006203651428223, -0.8409860730171204, 0.21232323348522186, 0.1696680635213852, -0.515275776386261, 0.030956830829381943, 0.5538027286529541, 0.2541806995868683, -0.7622585296630859, -0.02890099212527275, -0.5227040648460388, 0.05429057776927948, 0.16390393674373627, 0.23882639408111572, -0.027087736874818802, 0.33421966433525085, -0.10981277376413345, -0.655144214630127, 0.2157154232263565, -0.199846550822258, 0.30758926272392273, -0.5895175933837891, 0.058921366930007935, 0.1407984346151352, 0.32543623447418213, -0.4444524049758911, 0.01718207634985447, -0.023769784718751907, 0.6298378705978394, -0.15676060318946838, -0.2896985113620758, -0.5160500407218933, 0.09413962066173553, 0.20674186944961548, -0.17787915468215942, -0.4896516501903534, -0.049292705953121185, 0.22796200215816498, -0.10503816604614258, -0.42783063650131226, 0.20207156240940094, -0.36190348863601685, 0.06489346921443939, -0.6869470477104187, 0.051346562802791595, 0.017717599868774414, 0.5167437195777893, 0.6697450280189514, 0.06527156382799149, -0.07463912665843964, -0.4108424484729767, 0.13584035634994507, 0.12187865376472473, 0.0986565425992012, -0.7367850542068481, -0.506308913230896, -0.22399723529815674, -0.13990828394889832, 0.04205189272761345, -0.38126954436302185, 0.5596091151237488, -0.10123761743307114, -0.8108024597167969, -0.4936879575252533, 0.060396526008844376, 0.35930728912353516, -0.6384536623954773, -0.008464385755360126, -0.004318231716752052, -0.04388291761279106, 0.05422782525420189, 0.33844542503356934, 0.24900974333286285, -0.08584287762641907, -0.3378973603248596, 0.7426956295967102, 0.022704953327775, -0.7009710669517517, 0.05613996833562851, 0.20509423315525055, 0.5799894332885742, -0.2032572627067566, -0.08391174674034119, 0.18790306150913239, -0.05378152057528496, -0.40245169401168823, 0.5324124097824097, 0.350619912147522, -0.507269561290741, -0.05878093093633652, 0.07669873535633087, -0.45361316204071045, 0.7886188626289368, 0.001974700251594186, 0.28819218277931213, 0.5941316485404968, 0.8131842613220215, 0.387432724237442, -0.35684734582901, 0.8762043118476868, -0.14392352104187012, 0.3187711536884308, 0.38969066739082336, 0.3174436688423157, 0.6147746443748474, 0.4670971632003784, -0.20732316374778748, 0.21842485666275024, -0.24256682395935059, -0.08157708495855331, 0.26613014936447144, -0.41678059101104736, -0.08110968768596649, 0.1295783966779709, 0.7144850492477417, 0.5673463344573975, 0.2880285680294037, -0.07523255050182343, 0.14882390201091766, 0.3817870318889618, -0.04274257645010948, 0.13163049519062042, 0.14903803169727325, -0.25733381509780884, -0.11480948328971863, -0.2652779221534729, 0.007488461211323738, 0.03444203734397888, -0.18102796375751495, 0.19391050934791565, -0.18606580793857574, -0.25119173526763916, -1.0577645301818848, -0.030365709215402603, -0.19637298583984375, -0.11464739590883255, 0.1505064070224762, 0.1878708302974701, -0.4596455991268158, -0.3796079754829407, 0.40901121497154236, 0.682560920715332, 0.013430685736238956, -0.29962053894996643, 0.02403394691646099, -0.0698021948337555, -0.5344035029411316, 0.20406502485275269, 0.14353518187999725, -0.40115293860435486, 0.3308742642402649, -0.06260959059000015, 0.3841038644313812, 0.5144445896148682, 0.108153335750103, 0.0880693793296814, -0.043514758348464966, -0.42090514302253723, 0.38802024722099304, -0.39558321237564087, -0.25335705280303955, 0.3632649779319763, 0.17701278626918793, -0.22465644776821136, 0.033455342054367065, -0.6810412406921387, 0.0035024313256144524, 0.5501862168312073, -0.06263794749975204, -0.08172668516635895, 0.017223559319972992, 0.38908252120018005, 0.4711180329322815, 0.054817602038383484, -0.04350053146481514, 0.26077091693878174, -0.20612771809101105, 0.2932218313217163, -0.6962165832519531, 0.2846980094909668, -0.6104720234870911, -0.49396008253097534, -0.5853193998336792, 0.0469403974711895, 0.3575199246406555, 0.45642203092575073, -0.29054978489875793, 0.022835807874798775, 0.24769550561904907, 0.297092467546463, 0.6492195725440979, -0.07541289180517197, -0.3065163791179657, -0.35770735144615173, -0.07381107658147812, -0.28158119320869446, 0.5612500905990601, -0.08502257615327835, -0.24491097033023834, 0.1423797756433487, 0.10962307453155518, 0.37092122435569763, 0.16753888130187988, 0.41491782665252686, -0.32529062032699585, -0.465803861618042, -0.5255184769630432, 0.5534443855285645, -0.2777925431728363, 0.1897103488445282, 0.2590649724006653, 0.29440706968307495, 0.14905840158462524, -0.35596999526023865, -0.06301917135715485, -0.3771819472312927, -0.03404714912176132, -0.09309937804937363, 0.14676056802272797, 0.778051495552063, -0.1750766485929489, -0.27184441685676575, -0.5170764327049255, 0.36949390172958374, -0.44781479239463806, -0.8733124136924744, -0.037463899701833725, -0.05911790952086449, -0.14851650595664978, -0.06078587844967842, -0.24659110605716705, -0.2528672516345978, -0.23621821403503418, -0.459575355052948 ]
OBJECTIVE To investigate the association between gastric cancer and prior infection with Helicobacter pylori. DESIGN Case-control comparison of prevalence of IgG antibodies to H pylori in blood samples collected prospectively, before diagnosis of gastric cancer in the cases. Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). SUBJECTS 29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. RESULTS 20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. The median specific IgG concentration was significantly higher in the cases than controls (90 micrograms/ml v 3.6 micrograms/ml, p less than 0.01). The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). CONCLUSIONS H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.
[ 0.003248316701501608, 0.004711375571787357, -0.013483094982802868, 0.030267564579844475, 0.009207554161548615, 0.028598671779036522, 0.012581957504153252, 0.0005457587540149689, -0.020722005516290665, -0.018127087503671646, 0.00040860846638679504, 0.009915968403220177, -0.004567489493638277, 0.028081456199288368, 0.0045198178850114346, 0.0028674460481852293, -0.015086706727743149, 0.004744441248476505, 0.007464483380317688, 0.04627663269639015, 0.03254254162311554, -0.027618147432804108, 0.01205801498144865, 0.001560807228088379, 0.00368295144289732, 0.01207105815410614, -0.04003184288740158, -0.009226266294717789, 0.00696009024977684, -0.0038564871065318584, 0.015498092398047447, 0.010424205102026463, 0.047749802470207214, -0.06614294648170471, 0.0019269182812422514, -0.024133484810590744, -0.0031406318303197622, 0.021772723644971848, -0.011540757492184639, -0.0038244789466261864, -0.008072173222899437, -0.02125125378370285, -0.009565313346683979, -0.017866024747490883, -0.01231357641518116, -0.009714001789689064, -0.008562118746340275, 0.011408865451812744, 0.014605987817049026, 0.010311301797628403, -0.0005566672189161181, -0.016167161986231804, -0.02317074127495289, -0.007619599811732769, -0.008035564795136452, 0.023626990616321564, 0.024491120129823685, 0.0010936884209513664, -0.015400459989905357, -0.004764475394040346, 0.03109234943985939, -0.07079658657312393, 0.008630909025669098, 0.015500418841838837, -0.011634176596999168, -0.06574084609746933, 0.014996700920164585, -0.029259730130434036, -0.0061508044600486755, -0.003803633153438568, 0.01026852149516344, 0.014438383281230927, 0.013809561729431152, -0.013636782765388489, 0.003055999055504799, -0.026488108560442924, -0.01594529300928116, -0.0057701789774000645, 0.027064234018325806, -0.009983086958527565, -0.002880184445530176, -0.019013309851288795, -0.014161107130348682, 0.0307194534689188, -0.03562745824456215, 0.000986407045274973, -0.024036455899477005, -0.014294520020484924, 0.0014173906529322267, -0.001731283962726593, 0.008212510496377945, -0.03294144570827484, -0.04391776770353317, -0.020897693932056427, -0.02813219465315342, -0.015897685661911964, 0.0014548706822097301, -0.038832493126392365, -0.0007495656609535217, -0.020415768027305603, -0.012360119260847569, -0.007826085202395916, 0.025919735431671143, -0.006480392534285784, -0.006434766110032797, 0.007958970963954926, -0.026999033987522125, 0.02588191255927086, 0.007133903913199902, 0.012225000187754631, -0.033822908997535706, 0.0009097708389163017, 0.007761415559798479, 0.020124666392803192, 0.006184798665344715, 0.0061798314563930035, -0.00782158225774765, 0.012117328122258186, 0.0024782021064311266, 0.010115843266248703, 0.04300050437450409, -0.005674455314874649, -0.0067298319190740585, -0.012656977400183678, -0.0015677076298743486, 0.0036094021052122116, 0.025118254125118256, -0.012884780764579773, 0.02042822726070881, -0.008893623948097229, -0.007321892771869898, 0.0011440474772825837, 0.03194790333509445, -0.013435924425721169, -0.035891152918338776, 0.022759804502129555, -0.02201913297176361, 0.014228944666683674, -0.009315493516623974, 0.0007778019644320011, -0.03889862075448036, 0.009644895792007446, -0.0054549905471503735, 0.023283576592803, -0.024301446974277496, 0.02260897308588028, -0.02403932623565197, -0.0207781083881855, 0.024325937032699585, 0.0027572298422455788, 0.0033000349067151546, 0.0038280547596514225, -0.008018860593438148, -0.024782806634902954, 0.026293892413377762, -0.006071830168366432, -0.0007314224494621158, -0.024764932692050934, 0.008654050529003143, 0.004587207455188036, 0.014231866225600243, -0.05504481494426727, 0.025757459923624992, 0.014706224203109741, -0.017102517187595367, -0.012996433302760124, -0.007039432879537344, -0.015115750022232533, -0.006025247275829315, 0.008284937590360641, -0.004875074606388807, 0.008904775604605675, 0.007745204959064722, 0.0075119296088814735, -0.006867541000247002, -0.015067867934703827, -0.007616066839545965, 0.006671791430562735, -0.008875828236341476, 0.06525823473930359, 0.026503682136535645, 0.0027702413499355316, -0.037672556936740875, -0.04825057461857796, 0.037046950310468674, 0.0017345612868666649, -0.04472235590219498, -0.008650336414575577, -0.03050892800092697, -0.009938273578882217, -0.0008735763840377331, -0.019642924889922142, -0.02818828821182251, 0.01879638433456421, -0.0029491912573575974, 0.002020793966948986, -0.0030197869054973125, 0.006485718302428722, -0.006920580752193928, -0.028691867366433144, 0.03650178015232086, -0.01819181814789772, 0.021119890734553337, 0.006863726768642664, -0.037936314940452576, 0.010524258017539978, -0.0022269119508564472, -0.07662436366081238, -0.02332763373851776, -0.000985774677246809, 0.027979793027043343, -0.015501598827540874, -0.008531440980732441, 0.002478418406099081, -0.01079748198390007, 0.024018991738557816, -0.023930197581648827, -0.006606494076550007, -0.052328940480947495, -0.019730981439352036, 0.010403747670352459, -0.01222183182835579, -0.06142579764127731, -0.006352715194225311, -0.0038156751543283463, -0.04137919843196869, 0.010118748061358929, 0.009883034974336624, -0.029099617153406143, 0.0007777046412229538, -0.009735521860420704, -0.008860671892762184, -0.019318891689181328, 0.036808378994464874, 0.036988258361816406, 0.02889145538210869, 0.01985922083258629, -0.0020060637034475803, -0.00014482811093330383, -0.014462338760495186, 0.026351548731327057, -0.0051649753004312515, 0.06220931187272072, 0.020827865228056908, 0.006627955473959446, 0.0009995147120207548, 0.03572910651564598, 0.029023781418800354, 0.0008156695403158665, 0.0005408669821918011, 0.01362621784210205, 0.04050567001104355, -0.016966767609119415, -0.009124284610152245, 0.012814703397452831, 0.0009753163903951645, -0.017691083252429962, 0.02500847354531288, 0.029213180765509605, 0.012732391245663166, 0.018739208579063416, 0.010317224077880383, 0.013826312497258186, 0.009915055707097054, -0.013896754011511803, 0.022257335484027863, -0.005305441562086344, 0.04633491858839989, 0.0038051754236221313, -0.027159761637449265, 0.01651710644364357, -0.005304829217493534, -0.003382701426744461, -0.08077090233564377, -0.010674281045794487, -0.012546515092253685, 0.0009371954947710037, 0.015382523648440838, 0.041256096214056015, 0.007133567705750465, 0.020441768690943718, 0.007827785797417164, -0.03216779604554176, 0.0017599351704120636, 0.030174829065799713, -0.0069909412413835526, 0.002049229573458433, 0.0021006488241255283, 0.004548002500087023, 0.008494934998452663, -0.002645275089889765, 0.007728960365056992, -0.030931763350963593, 0.0003871337976306677, 0.028894707560539246, -0.012319712899625301, -0.011082700453698635, 0.024575676769018173, -0.0020299875177443027, -0.017997197806835175, 0.00860404409468174, -0.002492737490683794, -0.0019526423420757055, -0.01891322061419487, -0.02757522091269493, 0.021605927497148514, 0.023355726152658463, 0.027184806764125824, -0.037021204829216, -0.0013333023525774479, 0.015066309832036495, -0.03652666509151459, 0.03362119197845459, -0.030421903356909752, 0.0004946722183376551, 0.014560617506504059, -0.004371393471956253, 0.021925026550889015, 0.005153610371053219, -0.019058000296354294, 0.039662592113018036, 0.016413623467087746, 0.0061346800066530704, 0.0012139081954956055, 0.002797774039208889, -0.016502726823091507, 0.02221938595175743, -0.020529672503471375, -0.018865913152694702, -0.022588323801755905, 0.021072661504149437, -0.012753849849104881, -0.022860907018184662, 0.03383345529437065, -0.00013656355440616608, -0.011118033900856972, 0.03174617886543274, -0.026215452700853348, -0.033733196556568146, 0.016713375225663185, -0.010139022022485733, -0.008781565353274345, 0.013195077888667583, 0.02238885499536991, -0.008291274309158325, -0.03623607009649277, -0.0036080465652048588, 0.011030664667487144, -0.005765561945736408, -0.019587267190217972, -0.0038747775834053755, 0.005772547796368599, 0.002853166777640581, -0.0046594939194619656, 0.0027083461172878742, -0.01198563165962696, -0.00683069322258234, 0.005015605594962835, 0.006602575536817312, 0.008381064049899578, 0.03587943688035011, 0.026443105190992355, -0.015318111516535282, 0.015140440315008163, 0.025207679718732834, -0.00929291732609272, 0.016921915113925934, 0.01609429530799389, 0.002000165171921253, -0.007572075352072716, -0.010019307024776936, 0.03237371891736984, 0.008620621636509895, -0.034118760377168655, -0.013142237439751625, -0.040852319449186325, -0.012330463156104088, -0.0032455746550112963, 0.018103739246726036, -0.010387525893747807, -0.013778134249150753, -0.01859782077372074, -0.000958387041464448, -0.005993073806166649, -0.03390047699213028, -0.006606262177228928, 0.01261778362095356, 0.010158685967326164, -0.0015346216969192028, 0.009871653281152248, -0.005655867978930473, 0.07050865888595581, 0.019030865281820297, -0.00028757588006556034, -0.04056142270565033, 0.00391226215288043, -0.03399369865655899, -0.0033822900149971247, 0.016513317823410034, -0.030360614880919456, 0.016532549634575844, 0.01644487865269184, -0.04233672842383385, 0.011226017028093338, -0.027800049632787704, 0.007237136363983154, 0.017748411744832993, 0.007939446717500687, -0.007275708951056004, 0.01297084242105484, 0.01691502332687378, -0.03347320109605789, 0.024007242172956467, 0.009475220926105976, 0.02169455960392952, 0.020752189680933952, -0.024673424661159515, -0.02380349487066269, -0.015615396201610565, -0.038492366671562195, 0.01908104307949543, -0.01237971056252718, -0.023370960727334023, -0.008955876342952251, -0.007963813841342926, 0.014721990562975407, 0.04680684581398964, -0.0013446435332298279, 0.0024221865460276604, 0.009821729734539986, -0.016956975683569908, -0.004879032727330923, -0.01956491358578205, -0.02169625461101532, 0.01624823734164238, -0.03754502534866333, 0.008748561143875122, -0.003637158777564764, -0.007807777728885412, -0.012204146012663841, -0.0016729366034269333, -0.006292406935244799, -0.003163220128044486, 0.011042704805731773, 0.010798114351928234, -0.005095328204333782, 0.014080461114645004, 0.01232508011162281, -0.004276398569345474, -0.01062963530421257, -0.04496798664331436, 0.033367231488227844, 0.0018251240253448486, -0.016464758664369583, 0.008933978155255318, 0.0009579667821526527, -0.016780488193035126, -0.0015841402346268296, 0.007882535457611084, 0.0056047597900033, -0.006823346950113773, 0.027121666818857193, -0.007387635763734579, -0.016647839918732643, 0.0004572877660393715, -0.030293608084321022, 0.025693610310554504, 0.031185206025838852, -0.004390622489154339, -0.012550752609968185, 0.012853914871811867, -0.009115420281887054, 0.022631388157606125, 0.021593807265162468, -0.03145254775881767, 0.022888656705617905, 0.017981065437197685, -0.02730950340628624, -0.07396978884935379, -0.029426265507936478, -0.02032860554754734, -0.00783124566078186, 0.005053128581494093, 0.044616010040044785, -0.03315800800919533, 0.009246855974197388, -0.025373045355081558, -0.017756609246134758, -0.006577097810804844, -0.02703000046312809, 0.020408034324645996, 0.0279112346470356, 0.018030226230621338, 0.02120167203247547, -0.02460489608347416, -0.02885453961789608, -0.020748520269989967, 0.012465566396713257, 0.02573206089437008, -0.0035331789404153824, -0.03312864154577255, 0.007000495679676533, -0.0035498500801622868, -0.07903233170509338, -0.0010280674323439598, -0.02210806868970394, -0.0022751097567379475, 0.032826632261276245, 0.012652238830924034, 0.024611424654722214, -0.012048076838254929, -0.054760195314884186, -0.01933220401406288, 0.021317191421985626, -0.03454102203249931, -0.020747963339090347, -0.03245066851377487, 0.014240091666579247, -0.012319439090788364, 0.016154536977410316, 0.0026742382906377316, 0.03705211728811264, 0.025924287736415863, -0.019621163606643677, 0.054473478347063065, -0.006257569417357445, -0.008003240451216698, -0.007806702516973019, 0.0014208657667040825, -0.007484825327992439, 0.015650980174541473, 0.011959090828895569, 0.00026882754173129797, -0.027454499155282974, -0.05679590627551079, -0.02878161147236824, 0.004857516847550869, -0.009142812341451645, -0.029709096997976303, 0.035306043922901154, -0.005624874494969845, 0.010515349917113781, 0.004312899895012379, -0.007117012050002813, 0.041271597146987915, -0.013613266870379448, 0.002278749831020832, 0.02678976021707058, -0.02301022782921791, 0.00800646748393774, -0.014206325635313988, 0.021423276513814926, 0.005993748549371958, 0.0011074910871684551, 0.000270831398665905, -0.001092047430574894, -0.004209025297313929, 0.004558994900435209, 0.01638423465192318, -0.014938972890377045, 0.03564130887389183, -0.015701424330472946, 0.010518222115933895, 0.00892173033207655, -0.007570850197225809, -0.0070441709831357, 0.06996431946754456, 0.0021136016584932804, 0.013575582765042782, -0.001291478518396616, -0.0289114098995924, 0.001744036446325481, 0.013344815000891685, -0.004470291547477245, -0.028519604355096817, -0.014419078826904297, -0.006392050534486771, -0.012636588886380196, 0.0014365524984896183, 0.012490056455135345, 0.006610164884477854, 0.012942432425916195, -0.022927923128008842, 0.03250020742416382, -0.043753400444984436, -0.03275422379374504, 0.0130224684253335, -0.030207326635718346, -0.02150980569422245, 0.008230862207710743, 0.007122559938579798, -0.024853024631738663, -0.03592866659164429, 0.016533510759472847, -0.027290305122733116, 0.0053874049335718155, -0.017122186720371246, 0.015766456723213196, 0.00410082470625639, -0.020673025399446487, -0.008345559239387512, -0.008948187343776226, -0.03250303864479065, 0.020207632333040237, -0.010580819100141525, 0.007625474128872156, 0.02530703879892826, 0.0034909816458821297, -0.0003513311385177076, -0.03608245775103569, 0.04191385954618454, -0.05102168768644333, 0.004355108831077814, 0.012831533327698708, -0.005663878750056028, 0.018155856058001518, -0.014748888090252876, 0.0018090421799570322, 0.012262347154319286, -0.032236918807029724, -0.03654946759343147, 0.010007500648498535, -0.004292045719921589, 0.020533928647637367, 0.004835218656808138, 0.02966425195336342, 0.034864913672208786, -0.018201038241386414, -0.01306829508394003, -0.029582250863313675, -0.003569217398762703, -0.018838241696357727, 0.031721681356430054, -0.021654274314641953, -0.017199549823999405, 0.011744317598640919, -0.02045495994389057, 0.007252288982272148, 0.012226995080709457, 0.006722071208059788, 0.0075676776468753815, 0.01914236694574356, 0.046718306839466095, 0.027027519419789314, 0.0218985415995121, -0.010039073415100574, -0.024597492069005966, -0.005229943431913853, 0.023076046258211136, 0.013319001533091068, -0.05231425166130066, 0.0478905513882637, 0.0407906249165535, -0.039474375545978546, -0.006076750345528126, 0.004046896938234568, -0.0037064242642372847, 0.028754591941833496, -0.006569837685674429, 0.00504275830462575, 0.004726993385702372, 0.03666810691356659, 0.01916072517633438, 0.006935151759535074, 0.010248793289065361, -0.012164008803665638, 0.000308450311422348, 0.005569713190197945, -0.016884086653590202, 0.03478594869375229, 0.0052380645647645, -0.004068314563483, 0.03069356456398964, 0.0009174575097858906, 0.033952534198760986, -0.008125592023134232, 0.0009743161499500275, -0.018838074058294296, 0.057334814220666885, -0.000715956324711442, 0.020577169954776764, 0.008568299934267998, -0.005171892233192921, -0.018159596249461174, 0.0007718289270997047, -0.022676169872283936, 0.006977080833166838, -0.018698466941714287, 0.0025493691209703684, 0.027790024876594543, 0.04757148027420044, -0.026830419898033142, -0.007278477773070335, -0.003975083120167255, -0.015246168710291386, -0.01671690121293068, 0.018073800951242447, -0.012327817268669605, -0.021338149905204773, 0.010339523665606976, -0.015694892033934593, -0.012969289906322956, -0.021636582911014557, 0.011944986879825592, -0.022046569734811783, 0.019178127869963646, 0.02491079457104206, -0.01340576447546482, 0.0074950773268938065, -0.012315219268202782, 0.010719308629631996, -0.01733698509633541, -0.011708461679518223, 0.0275176502764225, 0.0008190884254872799, -0.0026524425484240055, 0.0025897047016769648, 0.016172120347619057, -0.022929057478904724, -0.005778299644589424, -0.019452933222055435, -0.0036054966039955616, 0.007042759098112583, -0.009229045361280441, -0.022250154986977577, -0.02640668675303459, -0.005945860408246517, -0.03163308650255203, -0.026432625949382782, -0.009414631873369217, 0.0018999457824975252, 0.02060728333890438, -0.0030413505155593157, 0.034314729273319244, 0.0274498388171196, -0.020825006067752838, 0.02535063400864601, -0.011607939377427101, -0.004934120457619429, 0.01763102039694786, -0.06721494346857071, 0.01496083103120327, -0.005995177663862705, -0.004402279853820801, 0.007773528341203928, 0.013660765253007412, 0.0032080323435366154, 0.003582228906452656, 0.020104151219129562, -0.020139917731285095, -0.008401062339544296, 0.014467217028141022, -0.0012824725126847625, 0.019490612670779228, 0.008704152889549732, 0.0007243109866976738, -0.0005095857195556164, -0.002495087217539549, -0.013071712106466293, 0.0460905022919178, -0.027869567275047302, 0.0010749949142336845, 0.004615765996277332, 0.006878291256725788, 0.00027899304404854774, 0.01995978131890297, 0.013777261599898338, -0.007282365579158068 ]
[ 0.45872557163238525, -0.14502352476119995, 0.31337305903434753, -0.03704708069562912, -0.2165357619524002, 0.4559600353240967, 0.2500782310962677, -0.5570168495178223, 0.10498008877038956, -0.14615915715694427, 0.008752971887588501, 0.33286914229393005, -0.30868515372276306, -0.1614021360874176, 0.09064328670501709, 1.0923447608947754, 0.5158401131629944, 0.2308739870786667, -0.057057153433561325, -0.7051083445549011, 0.09762510657310486, -0.2411126047372818, 0.20331910252571106, -0.19987919926643372, 0.2565234899520874, 0.244257390499115, 0.7905417680740356, 0.12485386431217194, 0.13246944546699524, -0.165719673037529, 0.0612875372171402, 0.42880719900131226, 0.16315586864948273, -0.2137143611907959, 0.0307688657194376, 0.35476043820381165, 0.35809841752052307, 0.08234082907438278, 0.37857887148857117, -0.5238392949104309, 0.009876737371087074, 0.03667713701725006, -0.44036605954170227, 0.7613808512687683, -0.30136704444885254, -0.4734121263027191, -1.4095662832260132, 0.18725883960723877, -0.37798550724983215, 0.42751172184944153, 0.3825390338897705, 0.4018280804157257, 0.007360166870057583, 0.20105211436748505, -0.07031127065420151, 0.7314686179161072, -0.4005836546421051, -0.29390648007392883, 0.1084689050912857, 0.009450056590139866, 0.11290273815393448, -0.3142378330230713, 0.27447211742401123, 0.437261164188385, 0.19769394397735596, 0.5581972599029541, -0.16299985349178314, 0.05351249873638153, -0.09893772006034851, -0.14950591325759888, 0.13576622307300568, -0.3170948624610901, -0.28695520758628845, 0.4424111843109131, -0.33301833271980286, -0.30298998951911926, -0.25919920206069946, -0.21375587582588196, 0.2988956570625305, 0.39304548501968384, 0.4479157626628876, -0.22302202880382538, -0.03067936934530735, -0.19190259277820587, 0.3939332664012909, 0.5832075476646423, -0.09672827273607254, 0.420319139957428, -0.4578445553779602, 0.4242044985294342, 0.05529234930872917, -0.45972585678100586, 0.4160844385623932, 0.47245293855667114, 0.2958807349205017, 0.26853278279304504, 0.1652429848909378, -0.31938305497169495, 0.22934655845165253, -0.1783953160047531, -0.12105444818735123, 0.45524898171424866, -0.602471649646759, -0.2410808801651001, -1.1795287132263184, 0.1568235605955124, -0.3636287748813629, -0.8009867072105408, -0.8704002499580383, 0.04686126112937927, -0.6562101244926453, 0.33187758922576904, -0.17718887329101562, -0.10299526900053024, -0.29170340299606323, 0.2506062388420105, 0.28117817640304565, -0.45264747738838196, -0.12498125433921814, 0.7698889374732971, -0.24412743747234344, 0.894736111164093, -0.06902400404214859, 0.3720080554485321, 0.2110530138015747, 0.11527379602193832, 0.505778431892395, 0.42597275972366333, 0.3086220622062683, 0.9026792049407959, -0.035222139209508896, 0.1052931472659111, -0.25385233759880066, -0.15079201757907867, -0.28456631302833557, -0.6625382900238037, 0.01402022410184145, 0.026443516835570335, 0.08042015880346298, 0.07731787860393524, -0.4645252525806427, -0.8164991736412048, -0.060222405940294266, -0.06847752630710602, 0.04796282947063446, -0.5106166005134583, 0.009248520247638226, 0.26182517409324646, -0.4258451759815216, -0.012960260733962059, 0.1960749477148056, 0.18223290145397186, -0.2756066918373108, -0.38010308146476746, -0.3310816287994385, 0.6432076096534729, -0.17636626958847046, -0.3375486135482788, -0.12357761710882187, 0.08554952591657639, 0.5100651979446411, 0.2672674357891083, -0.3402705192565918, -0.2746586203575134, 0.37395596504211426, -0.03718046844005585, 0.4092255234718323, 0.16962362825870514, 0.055130720138549805, -0.018403109163045883, -0.11096705496311188, -0.6649383902549744, 0.06205908581614494, -0.28073427081108093, -0.2599867284297943, -0.045451775193214417, 0.3149721324443817, 0.4542222321033478, 0.2643382251262665, -0.11532700061798096, -0.45998623967170715, -0.07275986671447754, -0.1355850100517273, -0.6380866169929504, -0.014149976894259453, 0.15136824548244476, 0.56268310546875, 0.18356440961360931, 0.07727914303541183, 0.6501322984695435, 0.23981063067913055, -0.24090267717838287, 0.35251477360725403, -0.7926445603370667, 1.499059796333313, -0.6643047332763672, -0.30088093876838684, 0.6617004871368408, 0.10709468275308609, -0.2855270206928253, 0.08403673768043518, 0.3094644248485565, 0.5737317800521851, -0.15351004898548126, -0.5973082780838013, -0.309641033411026, 0.06381833553314209, -0.25599727034568787, -0.4906435012817383, 0.6269217729568481, 0.2855548858642578, -0.20178724825382233, -0.25004154443740845, -0.4859358072280884, 0.24717369675636292, 0.37400978803634644, -0.07925990223884583, 0.42748507857322693, 0.3004463315010071, 0.11392799764871597, 0.7563133835792542, -0.49121129512786865, 0.5539616346359253, 0.20056410133838654, 0.009635694324970245, 0.40251410007476807, 0.5732806324958801, -0.15845005214214325, 0.6565330624580383, -0.8506800532341003, 0.10836327821016312, -0.5167038440704346, 0.6462264657020569, -0.2998778820037842, -0.20421096682548523, 0.027192605659365654, -0.18832148611545563, -0.31123071908950806, 0.5721248388290405, 0.08727236837148666, -0.16431500017642975, 0.3862798511981964, -0.31613409519195557, 0.1607452929019928, 0.05974682793021202, -0.064726322889328, -0.2646704316139221, 0.18965598940849304, -0.6941630244255066, -0.17318816483020782, 0.034938208758831024, 0.17242306470870972, -0.2755390703678131, -0.39190033078193665, 0.19416463375091553, 0.008860296569764614, 0.06443172693252563, -0.7543315291404724, 0.07467743754386902, -0.3492485582828522, -0.5591303706169128, 0.2209947407245636, 0.4330991804599762, 0.1463078409433365, 0.5172188878059387, -0.42675158381462097, -1.0679340362548828, -0.531211256980896, 0.35993775725364685, 0.6363652944564819, 1.0218290090560913, 0.4159410297870636, -0.3262285888195038, 0.2468334138393402, 0.2786649167537689, -0.26863589882850647, 0.22767092287540436, 0.8428436517715454, -0.7142070531845093, -0.7652266025543213, 0.08580699563026428, 0.09209000319242477, 0.4499923586845398, 0.006083065178245306, -0.20719726383686066, -0.1706802397966385, -0.14937184751033783, -0.5564241409301758, -0.20682837069034576, -0.5673889517784119, -0.011083913967013359, 0.9253610372543335, -0.1403302699327469, -0.6109991073608398, 0.2002105712890625, 0.10229694098234177, -0.6672595143318176, 0.8019397258758545, 0.6470010280609131, -0.2336910218000412, -0.24242521822452545, 0.263742595911026, -0.21229226887226105, -0.3786051273345947, 0.2922970950603485, -0.051679838448762894, -0.14265058934688568, 0.29067251086235046, -5.906550884246826, 0.23664960265159607, -1.0034257173538208, 0.5471886992454529, 0.0428701788187027, -0.11154356598854065, 0.8934798836708069, -0.12285640835762024, 0.1317979395389557, -0.09666064381599426, 0.23236225545406342, 0.3127211332321167, 0.24697431921958923, 0.1740940660238266, 0.0092682596296072, 0.48297351598739624, 0.4583987593650818, -0.13167394697666168, 0.5361093282699585, 0.25121432542800903, -0.3037038743495941, -0.3940947949886322, -0.04925820976495743, 0.2842661142349243, 0.543163001537323, 0.34347331523895264, -1.025309443473816, 0.4429027736186981, 0.20655056834220886, -0.11510749161243439, 0.22414714097976685, -0.6779738068580627, -0.24415263533592224, -0.3540836274623871, 0.2677393853664398, -0.08488347381353378, 0.2764644920825958, 0.04014473035931587, 0.1411178559064865, -0.3945564329624176, 0.03014364279806614, 0.3112942576408386, -0.5026834011077881, -0.2343103289604187, 0.11640135198831558, -0.23196065425872803, -0.05022493749856949, 0.2409374713897705, -0.21539147198200226, 0.33448511362075806, 0.39441773295402527, -0.07737540453672409, -0.26332688331604004, 0.3435918688774109, 0.05647805333137512, -0.26283201575279236, -0.17520283162593842, 0.645082414150238, -0.5038728713989258, 0.1711413860321045, -0.19264499843120575, -0.16786019504070282, -0.07493383437395096, -0.6729077100753784, -0.38862502574920654, 0.32039695978164673, -0.4077220857143402, -0.6351413130760193, -0.07478854060173035, -0.11763115227222443, -0.34973251819610596, 0.1810341477394104, 0.10542402416467667, -0.6824309229850769, -0.13985146582126617, -0.13758736848831177, 0.48882049322128296, 0.20989347994327545, -0.2864064574241638, -0.14116358757019043, -0.44826748967170715, -0.5238250494003296, 0.2952578067779541, 0.36534687876701355, 0.27387505769729614, -0.2865736782550812, 0.0540466234087944, 0.09452889859676361, -0.0223655067384243, -0.21725352108478546, 0.17708297073841095, -0.4110148251056671, 0.35914331674575806, 0.9441817402839661, 0.028458377346396446, 0.20122984051704407, 0.8980166912078857, 0.16210810840129852, 0.21031060814857483, -0.1687835305929184, 0.7886986136436462, 0.04379983991384506, -0.5126241445541382, -1.1506925821304321, -0.09616152197122574, 0.08126723766326904, -0.7207356691360474, -0.1665191501379013, 0.7639694213867188, -0.9087872505187988, 0.24401769042015076, -0.09781651198863983, -0.08518477529287338, -0.09634223580360413, 0.7498235106468201, -0.146812304854393, -0.1251387745141983, -0.21412663161754608, 0.6052205562591553, 0.09456878900527954, 0.05485719442367554, 0.15769216418266296, -0.3548937141895294, 0.19373081624507904, -0.22010456025600433, -0.4827709496021271, 0.4610736668109894, 0.5752031207084656, -0.8646808862686157, 0.042649321258068085, 0.05218765512108803, 0.4881531298160553, -0.5677173137664795, -0.13798123598098755, 0.315447598695755, -0.24112701416015625, -0.6247739791870117, 0.22137200832366943, 0.49858278036117554, 0.2635844647884369, 0.5661259889602661, -0.04481930285692215, -0.14247658848762512, 0.5062374472618103, 0.2315450757741928, -0.14951279759407043, -0.14075081050395966, -0.14636199176311493, -0.5321140289306641, -0.1334933489561081, 0.30134478211402893, -0.1234886646270752, 0.32001709938049316, -0.22392509877681732, -0.06773170083761215, 0.1317378133535385, 0.4514053463935852, 0.29513019323349, 0.06325136125087738, -0.7516115307807922, 0.48305076360702515, 0.016973426565527916, -0.9187979698181152, -0.10387717187404633, 0.33536356687545776, -0.2601829767227173, -0.21716223657131195, 0.23603907227516174, 0.06869231164455414, 0.3129991590976715, -0.08934292942285538, -0.705265998840332, 0.10053554177284241, -0.23188526928424835, -0.18357017636299133, 0.10839573293924332, -0.7421456575393677, 0.12956084311008453, -0.2002626210451126, 0.18879909813404083, 0.07807423174381256, -0.6742303371429443, -0.4079999029636383, 0.44630759954452515, 1.0599815845489502, 0.5975409746170044, -0.00590174738317728, -0.2893151342868805, -0.0271209254860878, 0.1564766764640808, -0.31535467505455017, 0.11939124017953873, 0.6925005912780762, 0.26784026622772217, -0.47642263770103455, -0.4706098139286041, -0.0149646932259202, 0.2950112223625183, -0.13330014050006866, -0.3242870271205902, 0.3011780381202698, 0.48956161737442017, -0.19780385494232178, 0.23461522161960602, 0.3014582395553589, -0.29938727617263794, -0.2931416928768158, 0.02282317541539669, -0.34166833758354187, -0.21846339106559753, -0.18882684409618378, -0.5556344985961914, 0.036356616765260696, 0.5349685549736023, -0.3298504948616028, 0.18105962872505188, -0.07932551205158234, -0.22873838245868683, 0.13776029646396637, 0.13949935138225555, 0.287110835313797, 0.10664438456296921, -0.2453896552324295, 0.10980105400085449, 0.027305684983730316, 0.03672070428729057, 1.1799036264419556, -1.0093573331832886, 0.06260362267494202, 0.09461446851491928, -0.252856582403183, -0.10132208466529846, 0.10214206576347351, -0.04983304813504219, -0.2428283393383026, 0.12803655862808228, -0.24417032301425934, 0.31193307042121887, 0.3486316204071045, -0.33635079860687256, -0.2517034709453583, 0.561613142490387, -0.2969530522823334, -0.1837434619665146, 0.03477995842695236, 0.1449509710073471, 0.30204007029533386, -0.3745189905166626, -0.5891085267066956, -0.2336454540491104, -0.07247071713209152, -0.37524542212486267, 0.301265150308609, -0.3592303693294525, 0.6037843823432922, 0.4303753674030304, -0.05947490409016609, -0.4000089764595032, -0.12888047099113464, 0.317626029253006, -0.06297505646944046, -0.295883446931839, -0.3963957130908966, -0.41006243228912354, 0.04288305342197418, 0.00801151990890503, -0.025752296671271324, -0.32598817348480225, -0.3128431439399719, -0.08689243346452713, -0.09832803905010223, 0.016501137986779213, 0.17217500507831573, 0.5546817183494568, -0.0971469059586525, 0.07135681062936783, -0.20113305747509003, -0.15270653367042542, -0.16138619184494019, 0.34573879837989807, -0.3290502429008484, -0.3384428024291992, 0.684233546257019, 0.00546727841719985, 0.27866148948669434, -0.5706914663314819, 0.03507416322827339, 0.1961965411901474, -0.4362463355064392, -0.3128770589828491, 0.2828368544578552, -0.05229950696229935, -0.8435892462730408, -0.8515809774398804, -0.02522590570151806, 0.3469838500022888, 0.13501209020614624, 0.11337199062108994, 0.19386382400989532, 0.10690613836050034, -0.3221454322338104, 0.7197800874710083, 0.3951547145843506, -0.36293894052505493, 0.21747387945652008, 0.2811373770236969, 0.3677494525909424, -0.31202659010887146, -0.0005765367532148957, -0.090521439909935, 0.28941524028778076, -0.0534246452152729, 0.5190558433532715, 0.15692172944545746, -0.7892765402793884, 0.06291615217924118, -0.3644002079963684, -0.23524393141269684, 0.44060829281806946, 0.38947856426239014, -0.015118087641894817, 0.6300064921379089, 0.954336941242218, 0.3737625181674957, -0.6760490536689758, 0.4123454988002777, -0.2689827084541321, 0.7945950627326965, 0.23978495597839355, 0.3529995083808899, 0.576102077960968, 0.5678887367248535, -0.27951034903526306, 0.3157259523868561, 0.24955220520496368, 0.6268080472946167, -0.3330543339252472, -0.2890132665634155, -0.27631714940071106, 0.3787474036216736, 0.6235431432723999, 0.45126038789749146, -0.10474414378404617, -0.49786102771759033, -0.2625505030155182, 0.6716333031654358, -0.5643008351325989, -0.10735348612070084, -0.009711287915706635, 0.6803123950958252, 0.15094004571437836, -0.11886411160230637, -0.46380043029785156, 0.003329115454107523, -0.7620028257369995, 0.14335666596889496, 0.005914559122174978, -0.4982633590698242, -0.8837090134620667, 0.023095203563570976, 0.0811513364315033, 0.297279417514801, -0.4700213074684143, 0.4211905300617218, -0.5989856719970703, -0.24211905896663666, 0.2969042956829071, 0.10902851074934006, 0.1928589642047882, 0.055492907762527466, -0.17059563100337982, -0.32301977276802063, -0.1816653460264206, -0.03143163397908211, 0.15755927562713623, -0.4452023208141327, -0.024141909554600716, -0.10997391492128372, -0.13291817903518677, 0.1468566507101059, -0.4337196946144104, -0.31887081265449524, -0.14026416838169098, -0.5024186968803406, -0.2506822943687439, 0.004712242633104324, -0.3064991235733032, 0.30807438492774963, 0.3180714249610901, 0.1990339308977127, -0.1878778636455536, -0.1761476844549179, 0.2658122777938843, 0.1424926370382309, -0.5052996873855591, -0.2004191279411316, -0.04120977595448494, -0.11598612368106842, 0.43212422728538513, 0.2751390337944031, -0.48058125376701355, -0.07722167670726776, -0.011369195766746998, 0.38415268063545227, -0.2135123908519745, 0.5907935500144958, -0.7939597964286804, 0.337044894695282, -0.4952521026134491, -0.2851857542991638, 0.5705673694610596, -0.09208787232637405, -0.3577478229999542, 0.07816063612699509, 0.01919730380177498, 0.06837733089923859, 0.04923226684331894, -0.2586463391780853, -0.10692515224218369, 0.04660557210445404, -0.2740989923477173, -0.48811277747154236, 0.30217283964157104, 0.04165283218026161, -0.8333420753479004, -0.11219151318073273, 0.17180456221103668, 0.14390622079372406, -0.011700094677507877, 0.4310532808303833, -0.27491605281829834, 0.04378096014261246, -0.547738790512085, -0.18333671987056732, -0.6226259469985962, -0.04653213545680046, 0.15493559837341309, 0.1661120504140854, 0.06426745653152466, -0.03505926579236984, -0.09052348136901855, -0.3485095202922821, 0.4133606553077698, 0.12590299546718597, 0.33491382002830505, 0.49872544407844543, 0.2558155655860901, -0.17430506646633148, -0.608690619468689, 0.7087477445602417, -0.44487622380256653, -0.019840972498059273, -0.174766406416893, -0.10503373295068741, -0.501146674156189, 0.12943564355373383, 0.4242108464241028, -0.5315096378326416, 0.10123384743928909, 0.11338257789611816 ]
Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are members of the interleukin-6 (IL-6) subfamily of cytokines that use a common signal transducer gp130. Human OSM (hOSM) and LIF share a functional high-affinity receptor that is composed of gp130 and LIF receptor beta subunit (LIFRbeta). A second high-affinity receptor for hOSM was recently found to be formed by gp130 and the hOSM receptor beta subunit. However, the nature of murine OSM (mOSM) and its receptors has remained unknown. Using the recently cloned mOSM cDNA, we produced recombinant mOSM and studied its biological activity and receptor structure. Murine hematopoietic cell lines M1 and DA1.a, an embryonic stem cell line CCE, and Ba/F3 transfectants expressing gp130 and LIFRbeta responded to murine LIF (mLIF) and hOSM equally well, while these cells responded to mOSM only at a 30-fold to 100-fold higher concentration than those of mLIF and hOSM. In contrast, NIH3T3 cells responded to mOSM, but not to mLIF and hOSM. Scatchard plot analyses showed that mOSM bound to gp130 with low-affinity (kd = 2.8 to 4.2 nmol/L) and that the binding affinity did not increase in the presence of LIFRbeta. However, mOSM bound to NIH3T3 cells with high-affinity (kd = 660 pmol/L), whereas mLIF did not bind to NIH3T3 cells at all. These results indicate that unlike hOSM, mOSM and mLIF do not share the same functional receptor, and mOSM delivers signals only through its specific receptor complex. Further studies in mice will define the physiological roles of OSM.
[ 0.009832481853663921, -0.00915624387562275, -0.026721591129899025, 0.014243001118302345, -0.0030483631417155266, -0.0025041503831744194, 0.011618038639426231, -0.0012588186655193567, -0.011747545562684536, 0.0019270596094429493, -0.010125646367669106, 0.007093982771039009, -0.005633308086544275, 0.027888018637895584, -0.0024844894651323557, -0.0042167119681835175, -0.04436293989419937, -0.016240939497947693, 0.011569521389901638, 0.05386775732040405, 0.005024002864956856, -0.002833936596289277, 0.0106936264783144, 0.016263457015156746, -0.008770570158958435, -0.0002068948233500123, -0.008377371355891228, 0.0073385522700846195, -0.0031129068229347467, -0.04032396525144577, 0.021663781255483627, -0.0026743048802018166, -0.007389525882899761, 0.04382055625319481, -0.008550338447093964, -0.01833179220557213, -0.014170657843351364, 0.023768078535795212, 0.03379187360405922, -0.005871542729437351, -0.0057480596005916595, -0.013500714674592018, 0.013329515233635902, -0.041838519275188446, -0.011002078652381897, -0.015988118946552277, -0.0037035136483609676, -0.00715227797627449, 0.012510396540164948, 0.0065720705315470695, -0.01804117113351822, -0.021492043510079384, -0.023994874209165573, 0.031019659712910652, -0.006711851805448532, 0.01562534272670746, 0.01918511837720871, -0.029987962916493416, 0.005775256082415581, -0.004631306044757366, 0.011605917476117611, 0.011572078801691532, -0.018971798941493034, -0.02123958431184292, 0.013870345428586006, -0.0661083459854126, 0.017387069761753082, -0.01009741798043251, 0.0010497625917196274, -0.004758468829095364, -0.005908885505050421, 0.016281623393297195, -0.01052251085639, -0.025928020477294922, -0.03205128759145737, -0.030049627646803856, -0.0011667816434055567, -0.016743948683142662, -0.035076823085546494, 0.02823222428560257, 0.005836114287376404, -0.0005014979979023337, -0.012211961671710014, -0.003537522628903389, -0.003605118952691555, -0.02369554713368416, -0.033558886498212814, -0.008984961546957493, 0.0026258453726768494, 0.024937544018030167, -0.000636533834040165, 0.028219271451234818, 0.013114694505929947, 0.015201341360807419, 0.01292533427476883, -0.030696524307131767, -0.036654241383075714, 0.0004604547284543514, 0.004127723164856434, -0.005380033981055021, -0.025184907019138336, 0.011437049135565758, 0.011314479634165764, 0.015222914516925812, -0.010608406737446785, 0.008700394071638584, 0.030464980751276016, 0.004749098792672157, -0.021326985210180283, 0.018326178193092346, -0.04410441964864731, 0.029958678409457207, -0.013291966170072556, 0.021767694503068924, 0.03203270584344864, 0.004480166360735893, -0.022477027028799057, 0.03273819386959076, 0.006702197715640068, 0.025336282327771187, -0.0030926705803722143, 0.005150297656655312, 0.0034678096417337656, 0.019861744716763496, -0.000746237812563777, 0.0013873931020498276, 0.00315653532743454, 0.0059052929282188416, -0.010569131933152676, -0.009050294756889343, -0.008775560185313225, 0.022306978702545166, -0.0018561581382527947, -0.02049870789051056, -0.022015556693077087, 0.0053758458234369755, -0.04498538002371788, -0.014933513477444649, -0.0061114695854485035, -0.018001167103648186, -0.004925736226141453, 0.014583669602870941, 0.014112826436758041, 0.0188731849193573, 0.03729672729969025, -0.02139180898666382, -0.01559481956064701, -0.000584463938139379, 0.005615347996354103, -0.006718616001307964, 0.020536411553621292, -0.0035550305619835854, -0.022815927863121033, -0.023376643657684326, -0.005358055699616671, 0.027439039200544357, -0.030934222042560577, -0.023952089250087738, 0.010698597878217697, -0.02144414559006691, 0.005736693739891052, -0.03366217762231827, 0.05018480122089386, 0.010522618889808655, 0.016324631869792938, 0.021835146471858025, 0.019159240648150444, -0.013854337856173515, 0.002825886243954301, 0.01126425713300705, -0.009154926054179668, 0.008658450096845627, -0.0016420939937233925, 0.013487294316291809, -0.01672818697988987, -0.0050566066056489944, 0.005061110481619835, 0.009056147187948227, -0.0036836997605860233, 0.0662183165550232, 0.030313534662127495, 0.001449455157853663, 0.016967803239822388, -0.025366300716996193, 0.01608368195593357, -0.012596490792930126, 0.012437315657734871, -0.013740901835262775, -0.01940765231847763, 0.025441499426960945, -0.011395290493965149, -0.01782919652760029, -0.025200005620718002, 0.029954371973872185, -0.03188565373420715, 0.002822978887706995, -0.01858980767428875, 0.01720224879682064, -0.007129370234906673, -0.0025546979159116745, 0.017992006614804268, -0.015586676076054573, 0.021454159170389175, -0.008972423151135445, 0.012921100482344627, 0.024950191378593445, -0.00825489591807127, -0.03203505277633667, -0.014421669766306877, 0.030836744233965874, 0.019552193582057953, -0.00006234319880604744, 0.005514008458703756, -0.009472234174609184, 0.016869299113750458, -0.011527188122272491, -0.022808508947491646, 0.03310135006904602, 0.018579913303256035, -0.013973906636238098, -0.009081996977329254, -0.017395760864019394, 0.0021067000925540924, -0.01187397912144661, 0.012393498793244362, 0.01066258829087019, 0.00803834106773138, 0.014838063158094883, 0.009458359330892563, 0.016593292355537415, -0.01743074506521225, -0.013038390316069126, -0.02116241678595543, -0.00567066902294755, 0.0152717474848032, 0.03341918811202049, 0.014362105168402195, -0.017825758084654808, 0.007474714890122414, -0.014162193983793259, 0.008133826777338982, -0.010267261415719986, 0.03563530743122101, -0.053380098193883896, -0.0024653885047882795, 0.007123126182705164, 0.03287940472364426, 0.0023158115800470114, -0.05092643201351166, -0.006759421434253454, 0.008700910955667496, 0.03208424896001816, 0.016248881816864014, 0.00020747771486639977, 0.01622450351715088, -0.0029964237473905087, -0.02447301149368286, -0.012898853048682213, 0.02498716488480568, 0.01763092912733555, -0.009058063849806786, 0.010695306584239006, -0.004748071543872356, 0.015046795830130577, 0.018159164115786552, 0.01091119833290577, -0.013370703905820847, -0.005676848813891411, 0.006226139608770609, -0.015806540846824646, 0.011029785498976707, -0.009154431521892548, 0.008304025046527386, -0.08066412806510925, -0.02585802599787712, -0.00845400057733059, 0.02829771116375923, 0.010660439729690552, -0.020668350160121918, 0.016821319237351418, 0.00761866569519043, 0.006943286396563053, -0.01864432543516159, -0.008087098598480225, 0.015425293706357479, -0.01700352504849434, 0.008767597377300262, -0.000033470336347818375, -0.006607523653656244, 0.015540949068963528, -0.004729770123958588, 0.0026377730537205935, 0.0038116006180644035, -0.0003899545408785343, -0.025208238512277603, 0.004958841484040022, 0.021418575197458267, -0.020607037469744682, -0.004124118015170097, 0.004609514027833939, -0.012745624408125877, -0.016261834651231766, -0.006421505473554134, -0.02429988607764244, 0.010660277679562569, -0.01351911760866642, -0.013197433203458786, 0.00445027370005846, -0.006994463503360748, 0.0030020256526768208, 0.002116014249622822, -0.01857665181159973, 0.013063048012554646, -0.03641579672694206, 0.013032916001975536, 0.027277342975139618, -0.001020162831991911, -0.014305648393929005, -0.006146252620965242, -0.019007772207260132, 0.014988548122346401, 0.01859574019908905, -0.022456027567386627, -0.007876998744904995, -0.006283515132963657, 0.009480814449489117, 0.019902072846889496, -0.018321754410862923, -0.011816928163170815, -0.008662776090204716, 0.02879735827445984, -0.005882305093109608, -0.009286216460168362, 0.03344733268022537, -0.00020741182379424572, 0.007514152675867081, -0.004077859688550234, 0.01484047994017601, 0.0031614929903298616, 0.010288503021001816, 0.004763190168887377, -0.013404807075858116, 0.018527861684560776, -0.0004153316840529442, -0.02398732863366604, -0.02777845598757267, -0.005788345355540514, -0.003875293768942356, -0.015153933316469193, -0.01474436093121767, -0.0002901165862567723, 0.01470242626965046, 0.012008604593575, -0.025445109233260155, 0.01615023985505104, -0.012232350185513496, -0.022882811725139618, -0.037918686866760254, 0.0034367358312010765, 0.008265838027000427, 0.009277520701289177, 0.0070868865586817265, -0.013544089160859585, 0.03154601901769638, 0.03469647467136383, 0.01720287650823593, 0.014425452798604965, 0.020745061337947845, 0.05096709728240967, 0.01739034801721573, 0.011993569321930408, 0.014635944738984108, 0.0075600226409733295, -0.010164234787225723, 0.00849244650453329, -0.032820336520671844, -0.015463164076209068, 0.018824439495801926, 0.015426697209477425, -0.002016429789364338, 0.006471356842666864, -0.001478696009144187, -0.001445957226678729, -0.014202665537595749, 0.000537247397005558, 0.00028095277957618237, 0.03177748620510101, 0.018389955163002014, 0.028662098571658134, -0.028825528919696808, -0.0010922332294285297, 0.07114174216985703, 0.020162779837846756, -0.007705578580498695, -0.013749759644269943, -0.007623807992786169, -0.03740023821592331, -0.00026251585222780704, 0.028432806953787804, 0.017039092257618904, -0.019813289865851402, 0.013461945578455925, 0.00564649049192667, -0.009821712039411068, -0.0059653399512171745, -0.00752344261854887, 0.014433247037231922, -0.04302765056490898, -0.009888803586363792, 0.029037650674581528, 0.019208572804927826, 0.0011956766247749329, -0.0034995125606656075, 0.015772059559822083, -0.024892956018447876, 0.021252285689115524, -0.032472383230924606, -0.013038384728133678, -0.01161169819533825, -0.03268885612487793, 0.012422679923474789, -0.011851008981466293, -0.012036830186843872, -0.014689787290990353, -0.005935697350651026, 0.00977730005979538, 0.0028715289663523436, 0.02972453087568283, -0.009741443209350109, 0.001709953648969531, 0.008866758085787296, 0.0016791047528386116, -0.018794003874063492, -0.023366108536720276, 0.008559580892324448, 0.02149132825434208, -0.037465404719114304, -0.007104199845343828, -0.00905358511954546, -0.02038302645087242, 0.007815781980752945, -0.0004282223526388407, 0.013059359043836594, 0.01191694661974907, -0.020676851272583008, 0.02339424192905426, -0.00872670765966177, 0.005299386568367481, 0.011846774257719517, -0.02331804670393467, -0.01728074625134468, -0.041297346353530884, 0.026159601286053658, 0.03200284019112587, 0.0007895673625171185, 0.02216203138232231, -0.03039420209825039, 0.021165188401937485, 0.02244032546877861, 0.034920863807201385, -0.006826850585639477, 0.01635274849832058, -0.008901655673980713, 0.011916308663785458, -0.007239875383675098, -0.025070983916521072, -0.012294155545532703, 0.0007255666423588991, -0.009857797995209694, 0.027596227824687958, -0.005136993248015642, -0.029100727289915085, -0.001570114865899086, -0.0012552272528409958, -0.045340072363615036, 0.011044580489397049, -0.0049386476166546345, 0.0035772565752267838, -0.07346402853727341, -0.003970095422118902, 0.003758395090699196, -0.006272881291806698, 0.03598973527550697, -0.0006517136935144663, -0.007807325571775436, 0.034774526953697205, -0.026536813005805016, -0.01064611878246069, 0.03152257949113846, -0.012912035919725895, 0.009996263310313225, 0.00970972515642643, 0.012151606380939484, -0.006073306314647198, 0.009065460413694382, 0.008821628987789154, -0.018882611766457558, 0.011812180280685425, -0.011976164765655994, -0.0057287015952169895, 0.007404355797916651, 0.004301987122744322, -0.004494990222156048, -0.07978161424398422, 0.004007367882877588, -0.005513353738933802, -0.038368724286556244, 0.002843957394361496, -0.02093704603612423, 0.011233989149332047, -0.006143368314951658, -0.05393338203430176, -0.016411492601037025, -0.008317933417856693, -0.003900317009538412, 0.021426815539598465, -0.023023612797260284, -0.011603128165006638, -0.008009670302271843, 0.02065935544669628, 0.009444152936339378, 0.012219388037919998, 0.02666909620165825, -0.014009196311235428, 0.004413018934428692, -0.010509450919926167, -0.001227264292538166, -0.007977917790412903, -0.0009017050033435225, -0.00165632925927639, 0.01645509898662567, -0.007275219075381756, -0.009070293977856636, 0.01970743015408516, -0.013489285483956337, -0.025048110634088516, -0.025657137855887413, -0.01782842166721821, -0.011400314047932625, -0.00735871959477663, -0.027222320437431335, -0.0612817220389843, 0.0014838846400380135, -0.0028863977640867233, -0.011716529726982117, 0.017291918396949768, 0.013702984899282455, -0.026662126183509827, -0.030664455145597458, 0.010316666215658188, -0.004417191259562969, 0.012549974955618382, 0.053314458578825, 0.01213826797902584, 0.016553346067667007, 0.004519898444414139, -0.0096314437687397, 0.005122417584061623, 0.0070970975793898106, -0.002037522615864873, 0.023047814145684242, -0.00538536487147212, 0.004838963039219379, -0.010996916331350803, 0.010504966601729393, 0.04301203042268753, 0.07127214968204498, -0.025147076696157455, 0.013914011418819427, 0.021599384024739265, -0.00021402898710221052, 0.003165016183629632, 0.001505252905189991, -0.04600747674703598, -0.025095265358686447, 0.006354677490890026, -0.007377919740974903, 0.00033494288800284266, -0.006197077222168446, 0.0238293819129467, 0.032467763870954514, -0.011089027859270573, 0.006534747313708067, -0.012996852397918701, -0.04199879243969917, 0.012753576040267944, 0.020841125398874283, -0.010556754656136036, 0.018557455390691757, 0.000018607766833156347, 0.02953130006790161, 0.004133523441851139, -0.012544440105557442, 0.038240380585193634, -0.021631289273500443, 0.000050479546189308167, -0.03460787609219551, -0.0010749965440481901, 0.0047723520547151566, 0.020947977900505066, 0.02296462655067444, -0.007290068082511425, 0.008385475724935532, 0.01841701939702034, 0.00892212800681591, 0.0010876050218939781, -0.005099860485643148, 0.006523155607283115, 0.005931883119046688, 0.001679851207882166, 0.02868122234940529, 0.008498817682266235, 0.0014221491292119026, 0.007944788783788681, 0.001494440482929349, 0.0011271123075857759, 0.011023323982954025, 0.003303002566099167, 0.002528759650886059, -0.03879941254854202, 0.02276872843503952, 0.05654819682240486, -0.008765281178057194, 0.01213025487959385, -0.04388214647769928, -0.014480230398476124, 0.01979890465736389, -0.014010744169354439, 0.04753429442644119, -0.011545664630830288, 0.0411607101559639, -0.02428709715604782, 0.016476141288876534, -0.01632709987461567, -0.027484064921736717, 0.01885879412293434, -0.023062169551849365, 0.0012174161383882165, 0.012671787291765213, 0.004543359857052565, 0.002773374319076538, 0.012867281213402748, 0.014030540362000465, 0.001711617922410369, 0.010188184678554535, 0.02598085068166256, -0.01720442622900009, -0.004013965837657452, -0.02144249714910984, 0.05247807130217552, -0.014053354039788246, 0.024585312232375145, -0.00044313794933259487, 0.016788270324468613, 0.0034242512192577124, 0.01645929366350174, 0.042375169694423676, -0.010416199453175068, -0.0010399320162832737, 0.016161514446139336, 0.010351136326789856, 0.0344364307820797, 0.032743003219366074, 0.021843131631612778, 0.012046005576848984, 0.036484088748693466, 0.013579281978309155, -0.00658838264644146, 0.03686946630477905, 0.012138948775827885, -0.02251274138689041, -0.0015876370016485453, 0.011887065134942532, 0.022608086466789246, 0.017266005277633667, -0.004432634450495243, 0.003403718350455165, 0.03953796625137329, 0.009626099839806557, -0.0022888733074069023, -0.0029508331790566444, 0.025910768657922745, -0.007931673899292946, -0.0007363841868937016, 0.0025937436148524284, -0.018833931535482407, 0.033124566078186035, -0.01647750660777092, -0.02101096138358116, 0.0238652341067791, 0.020533939823508263, -0.024396825581789017, -0.008525073528289795, 0.02964971959590912, -0.043397143483161926, -0.006228640675544739, 0.014602068811655045, -0.03330180421471596, 0.023511771112680435, -0.0005823653191328049, 0.006047971546649933, -0.009038755670189857, 0.011379859410226345, 0.013532375916838646, 0.0069296881556510925, -0.02257663384079933, -0.022298693656921387, -0.009441101923584938, -0.0027188402600586414, -0.004266474861651659, 0.009625542908906937, -0.021065689623355865, -0.017853833734989166, -0.0014033527113497257, -0.005442212335765362, 0.01106578391045332, 0.005484994500875473, 0.0137628223747015, 0.004963444080203772, -0.012637808918952942, 0.006378469057381153, 0.02698233723640442, -0.004188164137303829, 0.0077169667929410934, -0.004203174263238907, -0.029588909819722176, 0.0001610328909009695, 0.011895503848791122, -0.030217371881008148, -0.007157179992645979, -0.0047557298094034195, -0.0023534619249403477, -0.011247856542468071, -0.013719639740884304, -0.013571408577263355, -0.004023829475045204, 0.0027700832579284906, -0.062335263937711716, 0.00692784134298563, 0.03024839237332344, -0.027948562055826187, -0.00525969872251153, -0.021142365410923958, -0.017939532175660133, 0.015655260533094406, -0.02258003130555153, 0.000004713423550128937, -0.006074933335185051, 0.007175919134169817, -0.012769699096679688, 0.013716915622353554, 0.018735691905021667, -0.0030854283832013607, -0.023202091455459595, 0.003664921736344695, 0.008051285520195961, 0.007955227047204971, -0.003051657695323229, -0.017382584512233734, -0.006234745495021343, -0.006480418145656586, -0.0006000194698572159, 0.007177502848207951, 0.0029169078916311264, -0.006216088775545359, -0.03450312465429306, -0.0057514565996825695, 0.0011155589018017054 ]
[ -0.16048207879066467, 0.05102244392037392, 0.6218680143356323, -0.07974431663751602, 0.006734709721058607, 0.12320709973573685, -0.10105030983686447, -0.2187202423810959, -0.39534783363342285, -0.5505220890045166, -0.2375822812318802, 0.4572405517101288, -0.2993525564670563, 0.1348772495985031, 0.3112618029117584, 0.6079570651054382, 0.7705507278442383, 0.44319844245910645, -0.4054858386516571, -0.5054858922958374, 0.14846837520599365, -0.4266994595527649, 0.5008262395858765, -0.25052928924560547, 0.2986394464969635, -0.10166917741298676, 0.06661055237054825, -0.20342890918254852, 1.0067024230957031, 0.1634369194507599, -0.09487688541412354, 0.823680579662323, 0.23079445958137512, 0.04824084788560867, -0.22462479770183563, 0.291852205991745, -0.10609224438667297, 0.06905720382928848, 0.3326728641986847, 0.2861998677253723, -0.17505356669425964, -0.3718041777610779, -0.1822592318058014, 0.4054299294948578, -0.33701708912849426, -0.15758754312992096, -1.5166429281234741, 0.5579021573066711, -0.11764271557331085, 0.7539461255073547, -0.3778327405452728, 0.2972567081451416, 0.4962202310562134, -0.1354687362909317, 0.5738750696182251, 0.2410094290971756, -0.9435780048370361, 0.15895161032676697, 0.4936690628528595, -0.4995003640651703, -0.3784690797328949, 0.2859988808631897, -0.36561334133148193, -0.18025800585746765, -0.7665185332298279, 0.7680690288543701, 0.32072293758392334, -0.24769526720046997, -0.7327980399131775, -0.0408700555562973, 0.13026966154575348, -0.22188208997249603, -0.4943417012691498, 0.1514134258031845, 0.4461250603199005, -0.5510926842689514, -0.18164095282554626, -0.3600829243659973, 0.10773694515228271, 0.723311185836792, -0.18645153939723969, 0.323544979095459, 0.49332207441329956, 0.1325339525938034, 0.10032960772514343, 0.1370629519224167, -0.4123227298259735, 0.7484430074691772, -0.5188210010528564, -0.28822794556617737, 0.06690474599599838, -0.43745675683021545, 0.8680139780044556, 0.42419612407684326, 0.36608201265335083, 0.32457831501960754, 0.5264571309089661, 0.039645735174417496, 0.02838439680635929, 0.49509984254837036, 0.035197664052248, 0.05904741212725639, -0.2935835123062134, -0.5655083656311035, 0.03765992075204849, -0.09518944472074509, -0.06109892204403877, -1.2397103309631348, -0.28847429156303406, -0.262411892414093, -1.489408254623413, -0.32995399832725525, -0.4977085590362549, -0.6743889451026917, 0.027955560013651848, -0.49610212445259094, 0.16635072231292725, -0.5523121356964111, 0.028367582708597183, 0.0779222771525383, 0.1459442377090454, 1.010669469833374, 0.01832791231572628, 0.7066929340362549, 0.0022328845225274563, -0.3279237449169159, 0.10950077325105667, -0.23203067481517792, -0.19024384021759033, 0.7594811320304871, 0.05888203904032707, 0.6583379507064819, -0.07707120478153229, -0.15427961945533752, 0.20760822296142578, -0.03921407088637352, 0.18525449931621552, 0.2599816918373108, 0.04825793579220772, 0.5106126070022583, -0.6449292302131653, -0.5128290057182312, -0.6461244821548462, -0.07422343641519547, 0.13882219791412354, -0.4514472186565399, -0.46040084958076477, 0.06074151396751404, 0.08465815335512161, -0.5108343958854675, -0.06271985918283463, -0.4165988564491272, -0.4721517264842987, 0.4231520891189575, -0.12844188511371613, 0.1280699372291565, 0.11751223355531693, -0.22255055606365204, 0.19202880561351776, -0.09619078040122986, -0.0874011218547821, -0.46207964420318604, -0.20354041457176208, -0.17110781371593475, 0.3378200829029083, -0.013379188254475594, 0.2002338171005249, 0.24220900237560272, -0.00006304759881459177, -0.11783979088068008, -0.2725147008895874, -0.21446795761585236, 0.5159446001052856, -0.35637107491493225, -0.2637532651424408, 0.2285807728767395, 0.3725707530975342, -0.11321759223937988, 0.30482718348503113, 0.11140022426843643, -0.8794018626213074, -0.47225311398506165, -0.11098307371139526, -0.8571884036064148, 0.27232253551483154, 0.7285892367362976, 0.4760589599609375, 0.09268660843372345, 0.11842019110918045, 0.20819418132305145, -0.09520179778337479, -0.2740938365459442, 1.0720019340515137, -0.49567294120788574, 1.4851880073547363, -0.0858212485909462, -0.5576626658439636, 0.6029415130615234, 0.21263854205608368, 0.13151873648166656, -0.24858132004737854, -0.38164955377578735, 0.6286924481391907, -0.3105956017971039, -0.707324743270874, -0.004466349724680185, -0.26576682925224304, -0.4066031873226166, 0.04538317397236824, 0.08188776671886444, 0.44296547770500183, -0.37648525834083557, 0.05351469665765762, -0.36379650235176086, 0.2569171190261841, -0.6272761821746826, -0.11190704256296158, -0.3257843852043152, -0.6574347615242004, -0.1351141631603241, 0.44865697622299194, -0.6525995135307312, 0.4501301050186157, 0.6833306550979614, -0.4136175215244293, 0.598906934261322, 0.8167533278465271, 0.22330306470394135, 0.4711507558822632, 0.04635957255959511, 0.5162965655326843, -0.477568119764328, 0.2704664170742035, -0.3906005620956421, -0.10736171901226044, -0.10485149174928665, 0.683261513710022, 0.038587842136621475, 0.2361443042755127, -0.635769248008728, -0.16653132438659668, 0.9097171425819397, -0.640548050403595, 0.07113899290561676, 0.1147378534078598, -0.10771623253822327, -0.37648099660873413, -0.047109052538871765, -0.8633528351783752, 0.17095637321472168, -0.2043205052614212, -0.03259534388780594, 0.42423877120018005, -0.3797479271888733, 0.36777809262275696, 0.1991327702999115, 0.3715505599975586, -0.10894737392663956, 0.011960784904658794, -0.44153138995170593, -0.4432534873485565, -0.43453213572502136, 0.11824890226125717, 0.013606780208647251, -0.20734567940235138, -0.5192520618438721, -0.4375402331352234, 0.04026877135038376, 1.2100000381469727, 0.6345282196998596, 0.7594187259674072, -0.4157654047012329, -0.8178632855415344, -0.2572374939918518, 0.17464414238929749, -0.2767738401889801, 0.03329712525010109, 0.6846805810928345, -0.3852415382862091, -0.7203184366226196, 0.02956048585474491, 0.5979708433151245, 1.1913760900497437, 0.319620817899704, -0.017766883596777916, -0.22248612344264984, -0.04398875683546066, -0.5044437646865845, -0.34385859966278076, -0.568526029586792, -0.3399409353733063, 0.24613434076309204, -0.05892778933048248, -0.3670620322227478, 0.011228651739656925, 0.36883389949798584, 0.018784793093800545, 0.859650731086731, 0.4368666410446167, -0.4932655990123749, -0.3286871016025543, -0.006912166718393564, -0.09448260068893433, -0.0037499668542295694, 0.07041433453559875, 0.1652260720729828, -0.28436335921287537, 0.49910807609558105, -5.662799835205078, -0.004220510832965374, -0.6361574530601501, -0.2756524980068207, -0.07072947174310684, -0.43857431411743164, 0.683035135269165, -0.20182271301746368, 0.13810396194458008, -0.0342414490878582, 0.5259273648262024, 0.33998003602027893, -0.024944502860307693, -0.26310497522354126, -0.46911874413490295, 0.20846351981163025, -0.6314718127250671, -0.4387759566307068, 0.8122783303260803, -0.13531139492988586, 0.748370885848999, -0.4206724166870117, -0.23117198050022125, 0.6551929712295532, 0.3391663134098053, -0.09030752629041672, -1.1230775117874146, 0.2533595561981201, -0.26841551065444946, -0.7617306113243103, 0.32070741057395935, -0.18149417638778687, -0.19726845622062683, -0.4799789488315582, 0.8297850489616394, -0.3088509142398834, 0.18123644590377808, -0.16325274109840393, -0.32669904828071594, -0.6054463386535645, 0.11513743549585342, 0.06056280434131622, -0.120142363011837, -0.4129573404788971, 0.6463610529899597, -0.34550341963768005, -0.3637785017490387, -0.019438670948147774, -0.4532541036605835, 0.41700035333633423, -0.023572353646159172, -0.5077886581420898, -0.1999087929725647, 0.5414161682128906, 0.8112260699272156, 0.39239829778671265, -0.28224778175354004, 0.2556517422199249, -0.010925527662038803, 0.1820652037858963, -0.2247268110513687, -0.01786472462117672, -0.562615156173706, -0.505211591720581, -0.5098266005516052, 0.4683915078639984, -0.40631887316703796, -0.09904840588569641, 0.8934214115142822, -0.4970856308937073, -0.07381056994199753, 0.36097460985183716, 0.07054880261421204, -0.8854662775993347, 0.35719576478004456, 0.10983362048864365, 0.3666176497936249, -0.026353301480412483, -0.38406792283058167, 0.2167678326368332, -0.3845839500427246, -0.27452170848846436, -0.08307571709156036, -0.14190541207790375, -0.5303655862808228, -0.3216508626937866, -0.39945465326309204, -0.15611377358436584, -0.08563625067472458, 0.43414682149887085, 0.13972629606723785, -0.3034425675868988, 0.15858297049999237, 0.4525167942047119, -0.06312879920005798, -0.2519223690032959, 0.1624957025051117, 0.8436203598976135, 0.3090253174304962, -0.060812484472990036, 0.5167638063430786, 0.05719738081097603, 0.16278856992721558, -0.5793346762657166, 0.21083895862102509, 0.3053467571735382, -0.297335147857666, -0.001580434967763722, 1.0089077949523926, -0.6817685961723328, 0.2461390495300293, -0.00684936810284853, -0.26538223028182983, 0.05006133019924164, 0.4785165786743164, -0.4929777681827545, -0.2019471675157547, 0.0590592585504055, 0.46830666065216064, 0.07083909958600998, -0.1175999715924263, 0.5233352184295654, -0.6235412955284119, -0.2946358025074005, -0.7329029440879822, 0.07842196524143219, -0.09083635360002518, 0.1904710978269577, -0.6673950552940369, 0.02540421113371849, 0.3500925302505493, 0.5670419931411743, -0.30856049060821533, 0.14032281935214996, 0.14907363057136536, -0.3855520188808441, -0.2250663787126541, 0.671888530254364, 0.7387252449989319, -0.1411040723323822, 0.5919123291969299, -0.36422866582870483, -0.28119486570358276, -0.06163811683654785, -0.3251434564590454, 0.5306825637817383, 0.1809443235397339, 0.2299450933933258, -0.5455657839775085, 0.20008346438407898, 0.326901376247406, 0.13049015402793884, -0.2175968587398529, 0.037271592766046524, -0.08245309442281723, 0.445279985666275, 0.07235438376665115, 0.30776268243789673, 0.3949109613895416, -0.3886146545410156, -0.2203993946313858, 0.2941981852054596, -0.3201678991317749, -0.262109637260437, -0.21184100210666656, -0.4436284005641937, -0.23697970807552338, -0.25352799892425537, 0.02621990069746971, 0.3558109402656555, -0.19595038890838623, -0.20187561213970184, -0.2809225916862488, -0.33002662658691406, -0.24086838960647583, -0.4612124562263489, -0.32631009817123413, 0.09451944380998611, -0.44202372431755066, 0.358085960149765, 0.017877213656902313, -0.3087601065635681, -0.08799051493406296, -0.32706931233406067, 0.438683420419693, -0.24900119006633759, -0.08377014100551605, -0.5208790302276611, 0.4214807450771332, -0.48173463344573975, 0.09162025153636932, 0.013234147801995277, -0.43420150876045227, 0.00948031060397625, 0.36818867921829224, 0.09026559442281723, 0.29292622208595276, 0.39936625957489014, -0.03829024359583855, -0.8822066783905029, -0.07230452448129654, 0.69140625, -0.45483940839767456, 0.4338034689426422, 0.363815039396286, -0.2001827359199524, -0.20885366201400757, -0.1452089101076126, 0.17402148246765137, -0.5225095152854919, -0.06050119921565056, -0.5161657333374023, 0.149112731218338, 0.29849496483802795, 0.051540557295084, 0.22032491862773895, 0.5298359394073486, -0.24196508526802063, -0.3496086001396179, 0.22516122460365295, 0.11032335460186005, 0.02243775874376297, 0.047954775393009186, 0.02889043465256691, -0.5538934469223022, 0.24957913160324097, 0.4740743041038513, -0.6334145665168762, 0.6949209570884705, 0.02256310172379017, 0.2486191987991333, 0.19937120378017426, -0.28835195302963257, 0.3138669729232788, -0.15461836755275726, -0.2212173044681549, -0.45838117599487305, -0.08472813665866852, 0.14898623526096344, 0.6433712840080261, -0.01754395291209221, 0.41647565364837646, -0.3229961097240448, 0.33171698451042175, -0.05494373291730881, 0.41750261187553406, 0.3754854202270508, -0.8254831433296204, -0.20044080913066864, 0.18149985373020172, 0.2705947160720825, -0.3696567118167877, 0.47514182329177856, 0.311735600233078, 0.9071924090385437, -0.03129740059375763, -0.21786686778068542, -0.1967020332813263, -0.5009998083114624, 0.07527489960193634, -0.23083576560020447, 0.4331592321395874, -0.20623265206813812, 0.3696536421775818, -0.24184684455394745, 0.1305052787065506, -0.17197830975055695, -1.1933698654174805, 0.5509153008460999, -0.198418989777565, 0.15516681969165802, 0.26037096977233887, 0.7449889779090881, 0.6732268929481506, -0.1582104116678238, 0.6268985867500305, -0.3076905906200409, -0.1440270096063614, -0.21177567541599274, 0.03756057471036911, -0.17702056467533112, -0.051177650690078735, 0.3753170967102051, -0.44617971777915955, 0.3719668388366699, -0.9030019640922546, 0.1425294131040573, -0.5501784086227417, -0.288808673620224, -0.19136087596416473, -0.1650993674993515, 0.2735155522823334, -0.5800395607948303, -0.669364333152771, -0.1778206080198288, 0.14298288524150848, -0.304159015417099, -0.31530871987342834, -0.1042219027876854, 0.22013603150844574, -0.6925654411315918, 0.514543890953064, 0.07066616415977478, -0.1457727998495102, -0.16409900784492493, 0.19199465215206146, 0.04149988666176796, 0.17236149311065674, -0.467642605304718, -0.12880754470825195, 0.1300199031829834, -0.3342551589012146, 0.2004431039094925, 0.3084697127342224, -0.6099215745925903, 0.19208736717700958, -0.12336618453264236, 0.11327456682920456, 0.48255258798599243, 0.4506774842739105, 0.12958641350269318, 0.8267306685447693, 0.5361519455909729, 0.17117103934288025, -0.22952528297901154, 0.3133581280708313, 0.23970961570739746, 0.22849175333976746, 0.1718914657831192, 0.9328427314758301, 0.2860397696495056, 0.13282063603401184, -0.3315694332122803, 0.8503503203392029, 0.499024897813797, -0.11854633688926697, -0.020736778154969215, 0.09997440129518509, -0.28956764936447144, 0.5916287302970886, 0.5209887027740479, 0.5044309496879578, -0.17407888174057007, -0.08853201568126678, 0.5155689120292664, 0.2709505259990692, 0.03912428766489029, 0.11106707155704498, -0.01440424844622612, 0.21970951557159424, 0.1736026555299759, -0.24848681688308716, -0.5432415008544922, 0.09509871900081635, -0.6132673621177673, 0.5561050772666931, 0.039024047553539276, -0.4639771580696106, -0.5650218725204468, 0.5810989737510681, -0.07410717010498047, 0.13070611655712128, 0.003460409352555871, 0.738898754119873, -0.27910521626472473, -0.04703424498438835, 0.10554581135511398, -0.06774048507213593, 0.023440636694431305, -0.0422542467713356, -0.001242752419784665, 0.17533966898918152, 0.34283241629600525, 0.5044876933097839, -0.23429939150810242, -0.19996821880340576, 0.09231109172105789, -0.24688515067100525, 0.02657165564596653, 0.21964740753173828, -0.2494475543498993, 0.39949554204940796, -0.07803879678249359, -0.8785727620124817, -0.011434143409132957, -0.17871777713298798, 0.01622450165450573, 0.07159700989723206, -0.003150822827592492, -0.10596408694982529, 0.3927733600139618, -0.7629697322845459, 0.31121712923049927, -0.3596961498260498, 0.23610945045948029, 0.10012562572956085, -0.05240650102496147, 0.3419354557991028, 0.13279274106025696, 0.6225192546844482, 0.007193135563284159, 0.14754317700862885, 0.12123114615678787, 0.2500133812427521, -0.4005602300167084, 0.593323826789856, -0.45481517910957336, -0.3052535355091095, -0.32641610503196716, -0.3100365996360779, 1.0525974035263062, 0.9060273766517639, 0.0005207561189308763, 0.21980375051498413, 0.5351473689079285, 0.14379368722438812, 0.2381243109703064, -0.7512995600700378, -0.31690454483032227, -0.28112030029296875, 0.2361622303724289, -0.08164703845977783, 0.6146531105041504, 0.11617002636194229, -0.2985667288303375, -0.15290595591068268, 0.7712809443473816, 0.21272090077400208, 0.1398916244506836, 0.3633003532886505, -0.3054600656032562, 0.20025895535945892, -0.7512946128845215, 0.1289369761943817, -0.6844834089279175, 0.052067745476961136, -0.5239408612251282, 0.1761975735425949, -0.1016121581196785, -0.038388967514038086, 0.27591437101364136, -0.06121305748820305, -0.21438296139240265, -0.017487799748778343, 0.20429958403110504, 0.04133716970682144, -0.3308911621570587, -0.8819371461868286, -0.3563418686389923, 0.34870707988739014, 0.26677072048187256, -0.46164029836654663, -0.19160661101341248, -0.35509181022644043, 0.1440393626689911, 0.1428026556968689, 0.2002425342798233, -0.0748213604092598, 0.2685423791408539, 0.17788341641426086 ]
In vivo real-time epifluorescence imaging of mouse hind limb vasculatures in the second near-infrared region (NIR-II) is performed using single-walled carbon nanotubes as fluorophores. Both high spatial (∼30 μm) and temporal (<200 ms per frame) resolution for small-vessel imaging are achieved at 1–3 mm deep in the hind limb owing to the beneficial NIR-II optical window that affords deep anatomical penetration and low scattering. This spatial resolution is unattainable by traditional NIR imaging (NIR-I) or microscopic computed tomography, and the temporal resolution far exceeds scanning microscopic imaging techniques. Arterial and venous vessels are unambiguously differentiated using a dynamic contrast-enhanced NIR-II imaging technique on the basis of their distinct hemodynamics. Further, the deep tissue penetration and high spatial and temporal resolution of NIR-II imaging allow for precise quantifications of blood velocity in both normal and ischemic femoral arteries, which are beyond the capabilities of ultrasonography at lower blood velocities.
[ -0.013733068481087685, 0.003958425484597683, -0.013622632250189781, 0.00818696804344654, 0.0013871309347450733, -0.029881078749895096, 0.010259725153446198, 0.01624729298055172, -0.006413792259991169, -0.023521650582551956, -0.0056614321656525135, 0.00304429535754025, -0.018300946801900864, 0.004059434402734041, 0.01395280472934246, 0.03592999279499054, -0.03030915930867195, -0.0038043237291276455, 0.016216227784752846, -0.01613130234181881, 0.008257870562374592, 0.009309984743595123, 0.009275762364268303, -0.016962915658950806, 0.011832320131361485, -0.019687827676534653, 0.004251578357070684, -0.035488713532686234, -0.0093301460146904, 0.004587658680975437, 0.03104696422815323, -0.03016919270157814, 0.012928901240229607, -0.003083085175603628, 0.008679335936903954, 0.008154106326401234, -0.008752329275012016, 0.01732105389237404, 0.003971029072999954, -0.005548808723688126, -0.014944169670343399, -0.003949368838220835, 0.007116143126040697, 0.01734882965683937, -0.00768239377066493, -0.008901464752852917, -0.005539877340197563, 0.011245526373386383, -0.00883997417986393, 0.005264200270175934, -0.008573734201490879, -0.011685040779411793, -0.009281529113650322, 0.05352368578314781, -0.0071154204197227955, 0.015504056587815285, 0.016416065394878387, 0.022418692708015442, -0.02225417271256447, -0.010271131992340088, -0.011890670284628868, -0.020435426384210587, 0.008565760217607021, 0.025787804275751114, -0.009625313803553581, -0.066216379404068, 0.015403961762785912, -0.03095080703496933, 0.003869009204208851, -0.014466412365436554, -0.014860054478049278, 0.012801962904632092, -0.01932053454220295, 0.017583932727575302, 0.0012040785513818264, 0.009408639743924141, -0.022258643060922623, 0.010096903890371323, -0.00760366627946496, -0.0026190485805273056, 0.02008514478802681, -0.005582728423178196, 0.015133720822632313, -0.0007963739335536957, -0.005273324437439442, 0.03000703454017639, -0.022589117288589478, 0.004016141407191753, -0.00259280763566494, -0.018758723512291908, -0.008657614700496197, -0.0038943011313676834, -0.014009641483426094, -0.022261761128902435, 0.023451626300811768, 0.04460974782705307, -0.013263733126223087, 0.013388521037995815, 0.019135238602757454, -0.020266292616724968, -0.00515768863260746, 0.006424585357308388, 0.020978953689336777, 0.01303679309785366, -0.03415443003177643, 0.016335593536496162, 0.037345126271247864, 0.005181719083338976, 0.01811480149626732, 0.0027784090489149094, 0.01885150745511055, -0.008110785856842995, -0.02395779639482498, 0.009439432993531227, -0.0029931399039924145, 0.000641056802123785, 0.0019325909670442343, 0.025930680334568024, -0.004625844303518534, -0.03318725526332855, 0.012331782840192318, 0.02760113775730133, -0.006207204889506102, -0.03135751187801361, 0.011656633578240871, -0.024061374366283417, 0.0019682501442730427, 0.00719019491225481, 0.006189127918332815, -0.023760780692100525, -0.010763861238956451, 0.003225147258490324, 0.017613349482417107, -0.011902149766683578, 0.0014248229563236237, 0.0016497785691171885, 0.0047889272682368755, -0.009826208464801311, -0.008835702203214169, -0.01989899016916752, 0.04232607036828995, 0.016696441918611526, 0.006148311775177717, 0.007125798612833023, 0.009235737845301628, -0.0013343833852559328, 0.027965335175395012, 0.014957140199840069, 0.029396146535873413, -0.006235939450562, 0.017948154360055923, -0.020200731232762337, -0.008298937231302261, -0.02767045423388481, 0.004199921153485775, 0.005854482762515545, -0.03492698445916176, 0.014179142192006111, 0.001876965630799532, 0.02599194645881653, -0.0038044860120862722, 0.010492658242583275, 0.02149975672364235, 0.010858522728085518, 0.00038336217403411865, 0.018843919038772583, 0.01854426972568035, -0.012468211352825165, 0.006208055652678013, 0.00481827650219202, 0.004333212971687317, -0.0005794744938611984, -0.011063916608691216, 0.014749515801668167, 0.010540764778852463, 0.006188774015754461, 0.019328037276864052, 0.0073831952176988125, -0.007341627962887287, 0.06614692509174347, 0.010714821517467499, 0.0033089742064476013, 0.028355292975902557, 0.014091134071350098, 0.015484761446714401, -0.010240301489830017, -0.017108244821429253, 0.0008633250836282969, -0.0019295010715723038, -0.004623345099389553, -0.009701339527964592, -0.010594448074698448, 0.017855234444141388, 0.000935303745791316, -0.012305669486522675, 0.0034987973049283028, 0.004464654251933098, 0.018168281763792038, 0.019891824573278427, -0.019683144986629486, -0.020784327760338783, -0.021381506696343422, 0.015438294038176537, -0.03184860944747925, -0.006527245044708252, 0.010148245841264725, 0.02078648842871189, -0.01960642635822296, 0.01790780946612358, 0.016450367867946625, 0.02129700779914856, -0.026327161118388176, -0.01341971941292286, -0.010100388899445534, -0.021172814071178436, -0.010302672162652016, 0.022641059011220932, -0.002394678071141243, -0.009716608561575413, -0.007766075432300568, -0.004470955114811659, 0.030111633241176605, 0.020802680402994156, 0.035488441586494446, -0.0017116023227572441, 0.00717911496758461, 0.001980731962248683, 0.010707743465900421, 0.009341194294393063, 0.025571873411536217, -0.0035588329192250967, -0.019363168627023697, -0.015623202547430992, -0.026232022792100906, 0.023731466382741928, -0.016505680978298187, 0.012116147205233574, -0.02339114621281624, 0.01727304980158806, -0.008938174694776535, 0.0031492977868765593, 0.007484013214707375, -0.0014892914332449436, -0.01824791356921196, 0.014858022332191467, -0.006543884985148907, 0.025573518127202988, -0.0030339343938976526, 0.017807267606258392, -0.029727159067988396, 0.009745815768837929, 0.007400902919471264, 0.02101714164018631, 0.008497430011630058, -0.006217259913682938, -0.01850314624607563, -0.0029195761308073997, 0.03240266069769859, 0.02476121298968792, 0.01967449299991131, -0.0016384809277951717, 0.009024014696478844, 0.0025438922457396984, 0.015883469954133034, 0.009365148842334747, 0.019542468711733818, -0.016058778390288353, 0.020162217319011688, 0.006265182513743639, 0.011435935273766518, 0.007986434735357761, -0.017388280481100082, -0.008070861920714378, -0.0805869996547699, -0.006992612965404987, 0.018600307404994965, -0.004171375650912523, 0.006503352429717779, 0.0032154377549886703, -0.009332587942481041, 0.019553110003471375, 0.0020824179518967867, -0.011264078319072723, 0.0022842467296868563, 0.008626626804471016, -0.008106235414743423, 0.012449495494365692, -0.029071705415844917, -0.013948717154562473, 0.021645674481987953, -0.014903615228831768, -0.02289123646914959, 0.015029873698949814, -0.021377170458436012, -0.00026425602845847607, 0.0051561929285526276, 0.01570422574877739, 0.017512444406747818, 0.016821371391415596, 0.006190324667841196, 0.015090013854205608, -0.022717310115695, 0.010155266150832176, -0.0044954572804272175, -0.025474604219198227, 0.006157556548714638, 0.005532360170036554, 0.007929101586341858, -0.013695184141397476, -0.02065887302160263, -0.02200505882501602, -0.006418522447347641, 0.018430093303322792, -0.006080344785004854, 0.009992193430662155, 0.00007171416655182838, -0.0018294178880751133, -0.006131810136139393, 0.010992718860507011, 0.0039010057225823402, -0.021215353161096573, 0.03262973576784134, -0.02093716710805893, 0.013686218298971653, -0.0028066723607480526, -0.03765038400888443, 0.025543827563524246, -0.01763588935136795, 0.04007283225655556, -0.04347507655620575, 0.009000342339277267, -0.00715846661478281, -0.004122775513678789, 0.02206886187195778, 0.020004021003842354, 0.00950610637664795, -0.008853234350681305, -0.048353105783462524, 0.0027549159713089466, 0.0036242837086319923, -0.005463356617838144, -0.02570015750825405, 0.026339523494243622, 0.02753826417028904, 0.019024675711989403, -0.023848794400691986, -0.007912926375865936, -0.020246651023626328, -0.013716859742999077, -0.018953902646899223, -0.008761707693338394, 0.030406808480620384, 0.006582874804735184, -0.01645863987505436, 0.012902685441076756, 0.012778815813362598, -0.004025079309940338, -0.013596434146165848, 0.015270648524165154, 0.003638425376266241, 0.014601161703467369, 0.0047987718135118484, -0.01557178981602192, 0.0028779064305126667, 0.012432019226253033, 0.008967407047748566, 0.007360916584730148, -0.008314989507198334, 0.0020701922476291656, -0.005449660588055849, 0.028930675238370895, -0.006794361863285303, 0.009504065848886967, -0.0109489094465971, -0.014469362795352936, 0.01947120949625969, -0.00896269828081131, -0.025012195110321045, 0.01720612123608589, -0.007260148413479328, -0.015506499446928501, 0.003531488822773099, 0.0011060977121815085, 0.0009621373610571027, -0.03079599142074585, -0.011663563549518585, 0.0020955177024006844, 0.014055338688194752, 0.021795913577079773, -0.008932182565331459, -0.00846405141055584, 0.07168544828891754, 0.018063576892018318, 0.007733075879514217, -0.033630967140197754, 0.0020832642912864685, -0.024008357897400856, 0.0009149699471890926, 0.03769280016422272, -0.0002024684799835086, -0.009381483308970928, 0.012234341353178024, 0.002182974945753813, -0.01043408177793026, -0.014418539591133595, 0.008623150177299976, 0.009591755457222462, -0.006170600652694702, 0.007997090928256512, -0.007347697392106056, 0.05547301471233368, 0.016835585236549377, 0.002456864109262824, -0.002420831238850951, -0.019780565053224564, -0.0015689157880842686, -0.036644693464040756, 0.031034749001264572, -0.014388988725841045, -0.0017596393590793014, 0.015045685693621635, -0.03010079450905323, -0.019924363121390343, -0.007999320514500141, -0.014511294662952423, 0.03199269250035286, 0.013198323547840118, -0.027232538908720016, -0.01939624734222889, -0.018404528498649597, -0.01868627965450287, 0.014131957665085793, -0.01116432249546051, 0.05211523547768593, 0.013947412371635437, 0.040394045412540436, -0.021071195602416992, -0.014794407412409782, -0.008466463536024094, 0.0020570307970046997, 0.008199360221624374, -0.01817312464118004, 0.0035727813374251127, 0.012760590761899948, 0.014416201040148735, -0.01964716985821724, 0.0006512750405818224, 0.017709966748952866, -0.010706035420298576, -0.025929436087608337, -0.005897770635783672, 0.005151955410838127, -0.012562395073473454, -0.017724938690662384, -0.012020024470984936, 0.006821701303124428, -0.03467835858464241, -0.01694755256175995, -0.00402197428047657, 0.019277174025774002, 0.01017736829817295, 0.013205992989242077, 0.011850910261273384, -0.014997841790318489, -0.00776626355946064, -0.029308702796697617, 0.028426114469766617, 0.005836356431245804, 0.005361579358577728, 0.0020120430272072554, 0.016148444265127182, -0.03444666042923927, -0.001661902293562889, 0.01440499722957611, -0.032079678028821945, -0.012834087014198303, -0.01627025380730629, 0.01899203285574913, -0.07454070448875427, -0.018882721662521362, 0.014259534887969494, -0.006298763211816549, -0.007138305809348822, 0.0007097763009369373, -0.019044285640120506, -0.02121487818658352, -0.008099815808236599, 0.0027994527481496334, 0.032856933772563934, -0.009626765735447407, 0.056776903569698334, 0.00025350903160870075, 0.01112532988190651, -0.013800335116684437, -0.025232980027794838, 0.01967672072350979, -0.010875227861106396, -0.024611156433820724, 0.036254145205020905, 0.01317528635263443, -0.04629550501704216, 0.0016310669016093016, 0.0010454789735376835, -0.08049974590539932, 0.0005144616588950157, 0.005865640006959438, -0.01688779518008232, -0.014240144751966, -0.01179783046245575, 0.024041708558797836, -0.008766458369791508, -0.030540117993950844, -0.014318014495074749, -0.0028562266379594803, 0.02092251181602478, -0.015053040347993374, 0.0015206786338239908, 0.009190743789076805, -0.008708985522389412, 0.013780195266008377, 0.029559142887592316, 0.0024236063472926617, 0.005450649186968803, 0.011133231222629547, 0.004319323226809502, -0.010104766115546227, 0.012754169292747974, -0.0022855831775814295, 0.027203373610973358, -0.03543303534388542, 0.017604172229766846, -0.004577999003231525, -0.0016315723769366741, -0.0009706689743325114, 0.024365045130252838, -0.016938820481300354, 0.007633975241333246, 0.006935080513358116, -0.026911139488220215, 0.012334717437624931, -0.030872313305735588, -0.028218679130077362, -0.010800406336784363, -0.0031679365783929825, 0.021723860874772072, -0.022849619388580322, -0.006887194700539112, 0.013467378914356232, -0.026755550876259804, 0.004895495250821114, -0.008347196504473686, 0.012381654232740402, 0.006659255363047123, 0.011454281397163868, -0.018232962116599083, 0.00040721846744418144, 0.03466537594795227, -0.0007572425529360771, 0.023530494421720505, 0.0035709701478481293, 0.007560134865343571, -0.01501809898763895, 0.007829907350242138, -0.009633095003664494, -0.006400041747838259, 0.014358552172780037, 0.07113295793533325, -0.011115617118775845, 0.026875846087932587, -0.013075152412056923, -0.010674351826310158, 0.007697510998696089, -0.01792440190911293, -0.02727155014872551, -0.011075169779360294, -0.04698251187801361, 0.016653813421726227, -0.005156615283340216, -0.007763270754367113, 0.01420084573328495, -0.016015440225601196, -0.02666759118437767, -0.0036328211426734924, -0.012593772262334824, -0.011528167873620987, 0.003959692548960447, -0.006109471432864666, -0.013228199444711208, -0.031193828210234642, -0.024372458457946777, 0.03486458584666252, -0.003937841393053532, -0.006279305554926395, 0.02976984530687332, -0.0005114749073982239, -0.016465097665786743, -0.006650970317423344, 0.026208579540252686, 0.005477186292409897, -0.007191890385001898, 0.026597168296575546, 0.0002537677064538002, 0.019139131531119347, 0.01873326115310192, 0.01197497732937336, -0.03886893764138222, -0.012058954685926437, -0.0006015012040734291, -0.004035334102809429, 0.003820557612925768, 0.01844729669392109, 0.006809718441218138, 0.02518463507294655, -0.00045244302600622177, 0.008211243897676468, -0.003420906374230981, -0.002918597310781479, 0.001403503934852779, 0.019876660779118538, -0.03208065778017044, 0.01493457704782486, 0.014072692021727562, -0.008918499574065208, 0.021057352423667908, -0.00046463124454021454, 0.020479872822761536, -0.005840681958943605, 0.002448052167892456, 0.0021155308932065964, -0.012113234028220177, 0.01776318997144699, -0.010450734756886959, 0.0032521593384444714, -0.01961534656584263, -0.013327272608876228, 0.0175855103880167, -0.03362040966749191, 0.04264227673411369, 0.010730267502367496, 0.025503607466816902, 0.01975773461163044, 0.017818700522184372, 0.014460494741797447, 0.0012627714313566685, -0.0044358051382005215, 0.01201668195426464, -0.007942980155348778, -0.0008767601102590561, -0.0153881274163723, -0.007756189908832312, 0.008889598771929741, 0.0008252975530922413, -0.031077755615115166, -0.008165323175489902, 0.007744510658085346, 0.012185350060462952, -0.017455074936151505, 0.004591396544128656, 0.004717604257166386, 0.021827949211001396, -0.0010280119022354484, 0.03396483510732651, 0.012708785943686962, 0.006842213682830334, -0.012652925215661526, -0.001858206931501627, -0.002251219004392624, -0.002131266985088587, -0.006635788828134537, -0.007034854497760534, -0.020579185336828232, -0.0009614431764930487, -0.010725414380431175, 0.009347938001155853, -0.05025128647685051, 0.01729801669716835, 0.0005510975606739521, -0.01040659099817276, 0.0033223561476916075, -0.01605076715350151, -0.006874711252748966, -0.021201319992542267, -0.00647234870120883, 0.0038563921116292477, -0.027375750243663788, -0.008102665655314922, 0.008760626427829266, 0.020445359870791435, -0.0007087795529514551, 0.01536692027002573, 0.010620925575494766, -0.021598979830741882, -0.00489782216027379, 0.010666405782103539, 0.014847052283585072, -0.015736911445856094, 0.018533557653427124, -0.0049651749432086945, -0.0006980339530855417, 0.001794941257685423, 0.00987622793763876, 0.011934436857700348, 0.01912754774093628, -0.02577398158609867, 0.004904644098132849, -0.026478838175535202, -0.015647903084754944, -0.022067956626415253, 0.0032570548355579376, -0.004620295017957687, 0.006903285160660744, 0.010738998651504517, 0.024907268583774567, 0.022815607488155365, 0.0051025692373514175, -0.007735604885965586, -0.01393502950668335, 0.006338065955787897, 0.0013024825602769852, -0.007805226370692253, -0.007964707911014557, 0.002994044218212366, 0.0014523183926939964, 0.005092168226838112, -0.004972000140696764, 0.019144564867019653, 0.0372648611664772, 0.019345592707395554, 0.019612561911344528, -0.00965542159974575, -0.005161781795322895, -0.007486159447580576, 0.011868462897837162, 0.029578790068626404, -0.014518332667648792, -0.017170127481222153, 0.02633141726255417, 0.010894779115915298, 0.010509371757507324, 0.03265756368637085, 0.0021610804833471775, -0.015238284133374691, -0.017921365797519684, 0.011506898328661919, -0.02054598741233349, -0.006989565212279558, 0.014410038478672504, -0.014993824996054173, 0.021531619131565094, -0.013459297828376293, 0.024447578936815262, -0.0097510926425457, -0.005789446644484997, 0.004825260955840349, 0.0010214750654995441, -0.002673084381967783, -0.021200938150286674, 0.010392984375357628, 0.000511199701577425, -0.01644371822476387, -0.012668116018176079, 0.022186771035194397, -0.011769657023251057, -0.032198116183280945, 0.01363937184214592, 0.0021803826093673706, -0.0017215227708220482, -0.02106383442878723 ]
[ 0.14171069860458374, -0.1184115931391716, 0.2441340833902359, 0.1998804658651352, -0.024241853505373, 0.07191766053438187, 0.17944630980491638, -0.7028862833976746, 0.5142841339111328, -0.7909177541732788, 0.11201399564743042, 0.6483057737350464, 0.1314774751663208, -0.08414895832538605, -0.1145830824971199, 0.46104153990745544, 0.620294451713562, 0.17238762974739075, 0.022985845804214478, -0.502966582775116, -0.3391244411468506, -0.405411034822464, 0.33703744411468506, 0.22179439663887024, -0.4018395245075226, -0.056451644748449326, 0.6073204874992371, 0.40469786524772644, 0.17828136682510376, -0.21309663355350494, -0.18758229911327362, 0.09634815901517868, -0.3301396369934082, -0.5731614232063293, 0.4775956869125366, 0.20209446549415588, -0.19018562138080597, 0.0710316151380539, -0.23507218062877655, -0.21967339515686035, -0.368507981300354, 0.3916094899177551, 0.15593001246452332, 0.5004230737686157, -0.5702090859413147, -0.41536688804626465, -1.2287099361419678, 0.3483845889568329, -0.11879018694162369, 0.5441926121711731, 0.0005037270020693541, -0.0784372016787529, 0.7895928621292114, 0.2272767871618271, -0.3142557144165039, 0.41296669840812683, -0.36797183752059937, -0.0514608658850193, 0.36226603388786316, -0.5107267498970032, 0.042319200932979584, 0.09853435307741165, -0.30120381712913513, 0.07018823176622391, -0.18457604944705963, 0.12455400824546814, 0.399693101644516, -0.6886835098266602, -0.16431480646133423, 0.03890161216259003, 0.8156787753105164, 0.3518698215484619, -0.2553611695766449, 0.2801592946052551, -0.28361406922340393, -0.24690502882003784, -0.027052398771047592, 0.030662931501865387, 0.42353758215904236, 0.17276379466056824, 0.24521397054195404, -0.18268844485282898, 0.1027587428689003, 0.21902813017368317, 0.4943670332431793, 0.3139815032482147, -0.10715287178754807, 0.5137964487075806, -0.9113397598266602, 0.1397504061460495, -0.19478540122509003, -0.3987509608268738, 0.09471094608306885, 0.33392608165740967, 0.367571622133255, 0.3481099009513855, 0.12424402683973312, -0.21537652611732483, 0.3166600465774536, 0.18382227420806885, -0.059621457010507584, -0.39922264218330383, -0.021172285079956055, -0.2245403677225113, -0.08360697329044342, -0.36495906114578247, -0.9116688966751099, -0.4867077171802521, -0.4704064130783081, 0.3288276493549347, -0.3819408714771271, 0.025106802582740784, -0.09128069877624512, -0.44755423069000244, -0.35908839106559753, 0.09494857490062714, 0.16633452475070953, 0.06281471252441406, -0.12256426364183426, 0.1951749622821808, -0.39494702219963074, 1.3370506763458252, 0.19165034592151642, 0.22288373112678528, -0.16132286190986633, 0.0616094246506691, 0.6117895841598511, 0.28467264771461487, -0.5223556160926819, 0.2700751721858978, 0.19078662991523743, 0.5828920006752014, 0.016385992988944054, -0.096930131316185, 0.1522112935781479, -0.35187506675720215, 0.5160226225852966, -0.09930206090211868, -0.16833551228046417, 0.3528776168823242, -0.13370852172374725, -0.7275950908660889, -0.40110188722610474, 0.17845439910888672, 0.3981417119503021, -0.6160984635353088, 0.10003148019313812, -0.06450770050287247, -0.8170608878135681, 0.07246500253677368, -0.47308579087257385, 0.32628142833709717, -0.28977879881858826, -0.34059640765190125, -0.3096347451210022, 0.5072458982467651, -0.08625651895999908, -0.12770141661167145, 0.1549890637397766, 0.0840088501572609, 0.41050589084625244, -0.2533072829246521, -0.7764214277267456, -0.045269038528203964, 0.08587902039289474, -0.18969343602657318, 0.5651015043258667, 0.7555421590805054, -0.15859468281269073, 0.34412628412246704, 0.5263071060180664, -0.2870509922504425, 0.13459593057632446, -0.36907175183296204, -0.2752363979816437, 0.1262759119272232, -0.008126441389322281, 0.16935791075229645, -0.0321599580347538, -0.06910152733325958, -0.6523590683937073, -0.18656454980373383, 0.04027196764945984, -0.291490375995636, -0.012864604592323303, 0.011892936192452908, 0.763830840587616, 0.4721345901489258, -0.29829880595207214, 0.03655171021819115, -0.12124807387590408, -0.4620300233364105, 0.6745331287384033, -0.9660109877586365, 1.5749626159667969, -0.030350543558597565, 0.0018016444519162178, 0.7664070725440979, -0.16079923510551453, -0.17312312126159668, -0.1338372826576233, 0.21391665935516357, 0.3212136924266815, -0.24493739008903503, -0.426420658826828, -0.3514992296695709, 0.291485995054245, -0.32603442668914795, 0.22194066643714905, 0.058197252452373505, 0.48180869221687317, -0.39642801880836487, 0.10318322479724884, -0.1589413285255432, 0.25726160407066345, -0.45462730526924133, -0.14214693009853363, 0.29795190691947937, 0.024944668635725975, 0.22417953610420227, 0.7928223609924316, -0.26488062739372253, 0.4963628053665161, 0.4184972941875458, -0.062199246138334274, 0.6885010004043579, 0.4895671606063843, 0.03178775683045387, 0.7057240009307861, -0.2525501847267151, -0.1759345382452011, -0.28955110907554626, 0.3246130049228668, -0.2723658084869385, 0.03809541463851929, -0.08221428841352463, 0.4251880347728729, -0.4072183072566986, 0.48209935426712036, -0.07460898905992508, -0.08984321355819702, 0.6316741108894348, -0.2877516448497772, 0.2504916489124298, 0.17026562988758087, -0.3703363537788391, 0.3235296607017517, 0.6042266488075256, -0.6188979744911194, -0.29712948203086853, 0.07953626662492752, 0.18505236506462097, -0.46550554037094116, -0.4742897152900696, 0.225367471575737, -0.2955870032310486, -0.07528279721736908, -0.40803593397140503, -0.20923881232738495, -0.1403367519378662, 0.08527708053588867, -0.13691575825214386, 0.5047316551208496, 0.18465855717658997, -0.31716686487197876, -0.48347002267837524, -0.6934455633163452, -0.6188510656356812, 0.9700892567634583, 0.5947816967964172, 0.5004498362541199, 0.4848199188709259, -0.363695353269577, 0.17089113593101501, 0.21504980325698853, -0.019008202478289604, 0.19004520773887634, 0.280327707529068, -0.2715420722961426, -0.13632498681545258, 0.2490319460630417, 0.5361843705177307, 0.6881387829780579, -0.19537141919136047, -0.7882688045501709, -0.5404540300369263, 0.05809544771909714, -0.30539393424987793, -0.4340091049671173, -0.18626175820827484, -0.021534454077482224, 0.43194156885147095, 0.0025884434580802917, -0.20034921169281006, -0.3553280532360077, 0.7134994864463806, 0.031854648143053055, 0.28656864166259766, 0.4344176650047302, -0.3548777997493744, -0.36089637875556946, -0.40823814272880554, -0.4580122232437134, -0.15107296407222748, -0.15031100809574127, -0.46640241146087646, -0.3212370276451111, -0.10141333937644958, -5.87207555770874, 0.3768337368965149, -0.3526206612586975, 0.13536985218524933, 0.023487547412514687, -0.18496938049793243, 0.8352459073066711, -0.07739893347024918, 0.13316793739795685, -0.002805679803714156, -0.029250089079141617, 0.7904747724533081, 0.12510783970355988, -0.04959508031606674, 0.13375981152057648, 0.12259090691804886, 0.20947228372097015, -0.2767048180103302, 0.2432602196931839, -0.2502932548522949, 0.10872647911310196, -0.012226310558617115, -0.24423010647296906, 0.5327385663986206, 0.6391695141792297, -0.1437731832265854, -1.2557708024978638, 0.05305449292063713, 0.17944033443927765, -0.35873329639434814, -0.35218843817710876, -0.7788597345352173, -0.28690004348754883, 0.2887919247150421, 0.5712230801582336, 0.3473851978778839, 0.41076672077178955, 0.006438528187572956, 0.4197200834751129, -0.4395785331726074, 0.3521967828273773, 0.8057852983474731, -0.6397486329078674, 0.1001107469201088, 0.40358391404151917, -0.5694525241851807, 0.07695984840393066, 0.5587289929389954, 0.440432071685791, 0.3814396858215332, -0.3411705791950226, -0.33710214495658875, 0.22443923354148865, 0.12240519374608994, 0.27660590410232544, -0.5799859166145325, -0.07090138643980026, 0.4328807294368744, 0.051952481269836426, -0.06611432880163193, -0.4794173538684845, -0.5871784090995789, -0.3898184597492218, -0.842644453048706, -0.12737645208835602, 0.34769299626350403, -0.5474019050598145, -0.46576061844825745, 0.02844086103141308, -0.06930658966302872, -0.1857040524482727, 0.3983473777770996, -0.00869771558791399, -0.5025398135185242, 0.736562967300415, -0.2938412129878998, 0.47972506284713745, -0.40523186326026917, -0.3744942545890808, 0.19552543759346008, -0.058497510850429535, -0.4133948087692261, -0.007993499748408794, 0.5556821227073669, 0.06064356490969658, -0.6190080642700195, -0.1629817634820938, -0.8074671030044556, -0.16312162578105927, 0.07587645202875137, 0.5663372874259949, -0.4357851445674896, -0.045531343668699265, 0.6527664065361023, -0.21914808452129364, -0.12414189428091049, 0.25745129585266113, 0.1855916678905487, 0.2742210328578949, 0.14730556309223175, 0.8262853622436523, 0.464651882648468, -0.5584197044372559, -0.8906096816062927, -0.014963094145059586, 0.4093637764453888, -0.4733544886112213, 0.30599042773246765, 0.5547322630882263, -0.20562942326068878, -0.29288405179977417, 0.015727657824754715, -0.22189365327358246, 0.3398919403553009, 0.3565734624862671, -0.21566984057426453, -0.5614714622497559, -0.006132644601166248, 0.605036735534668, -0.2006063610315323, 0.01875312253832817, 0.01735660247504711, -0.575564444065094, 0.40729594230651855, 0.16174425184726715, -0.17272597551345825, 0.21032610535621643, 0.5248689651489258, -0.5863953232765198, -0.06292032450437546, 0.3031458854675293, 0.4518856704235077, -0.3571886420249939, 0.0987815409898758, 0.2175690233707428, -0.4559706449508667, -0.48997563123703003, -0.16239973902702332, 0.24204863607883453, -0.3245690166950226, 0.2788335382938385, -0.21788369119167328, 0.09008097648620605, -0.2906462848186493, -0.3708380162715912, 0.13298140466213226, 0.008219901472330093, -0.12128374725580215, -0.5901479125022888, 0.2991943955421448, -0.058291152119636536, -0.2446902096271515, -0.07067025452852249, -0.07004943490028381, 0.06945474445819855, -0.5372034311294556, 0.06480081379413605, -0.16267071664333344, 0.42320653796195984, 0.09151078760623932, 0.21750999987125397, 0.5856925845146179, -0.537243127822876, 0.3884715437889099, -0.24768905341625214, -0.2789255976676941, -0.42562130093574524, 0.2547239065170288, -0.45537427067756653, -0.07836896926164627, -0.2774592936038971, -0.6022815108299255, 0.3840007185935974, -0.35844287276268005, 0.09124770760536194, -0.005317440256476402, -0.20442718267440796, 0.4028748571872711, -0.15186366438865662, -0.1904284507036209, 0.7356606721878052, -0.568196177482605, -0.06073269620537758, 0.21929359436035156, 1.0019958019256592, 0.038082048296928406, -0.2494322657585144, -0.320584774017334, -0.03285887464880943, 0.20851632952690125, 0.26663100719451904, 0.753761351108551, 0.39049139618873596, -0.18811075389385223, -0.09286282956600189, -0.2014324814081192, 0.3863967955112457, 0.7176463007926941, 0.019713183864951134, -0.3154571056365967, -0.002141697332262993, 0.2322467714548111, -0.6501756310462952, 0.5088381171226501, 0.13693273067474365, 0.062496382743120193, -0.3682636022567749, 0.42047467827796936, -0.08132588863372803, -0.5673142075538635, -0.3898180425167084, -0.22262084484100342, -0.015322916209697723, 0.015608370304107666, -0.5761733055114746, 0.4509950876235962, 0.5785821080207825, -0.18787969648838043, -0.034813378006219864, 0.295074462890625, 0.37344759702682495, -0.2681420147418976, -0.03835137188434601, 0.27039676904678345, -0.24275384843349457, -0.042314618825912476, 0.07999958097934723, -0.48804062604904175, -0.20628981292247772, -0.12557168304920197, -0.5586172342300415, -0.16897264122962952, -0.02620071731507778, -0.2910996079444885, -0.1264980137348175, 0.29450535774230957, -0.2552264928817749, 0.04993942007422447, -0.2506958544254303, -0.08774370700120926, 0.274955153465271, 0.4609864354133606, -0.6572494506835938, 0.3847695291042328, -0.30568602681159973, 0.421682208776474, 0.13221865892410278, -0.5941747426986694, -0.8855271339416504, -0.2382570058107376, 0.41623052954673767, -0.2822625935077667, -0.16685523092746735, 0.20060263574123383, 0.9166682958602905, 0.11606516689062119, -0.06615284085273743, -0.34579676389694214, -0.2583327293395996, 0.5050479769706726, -0.30475127696990967, -0.3201482594013214, -0.294747531414032, -0.2929445505142212, 0.39787498116493225, -0.05068507418036461, -0.15823598206043243, -1.0224581956863403, 0.28856655955314636, 0.10458499938249588, 0.1983645260334015, 0.2375125139951706, 0.15479107201099396, 0.18253248929977417, -0.2818585932254791, 0.3290082514286041, -0.3791173994541168, 0.6530595421791077, -0.3556383550167084, 0.12019571661949158, -0.22395460307598114, -0.4441412687301636, 0.3123028874397278, -0.27512654662132263, 0.10146686434745789, -0.06522788107395172, 0.28843939304351807, -0.3117845058441162, 0.014831394888460636, -0.34997352957725525, 0.13195578753948212, -0.17040808498859406, -0.9200085401535034, -0.30469420552253723, 0.28748512268066406, 0.3997221887111664, 0.24145284295082092, 0.22380885481834412, -0.05841187760233879, -0.3401496112346649, -0.2284332811832428, 0.8745895028114319, 0.8395408391952515, -0.6466822028160095, 0.6319030523300171, 0.05776871740818024, 0.6271008849143982, 0.15950670838356018, -0.1494525521993637, -0.17962349951267242, 0.22013084590435028, 0.08041723072528839, -0.40772831439971924, 0.7321304082870483, -0.07628034800291061, -0.004259883426129818, -0.14503143727779388, 0.1391524225473404, 0.28616201877593994, 0.015527540817856789, -0.3184012770652771, 0.29440560936927795, 0.4152151942253113, -0.19907288253307343, -0.5505476593971252, 0.06089901924133301, 0.014063932932913303, 0.41299423575401306, -0.03519059345126152, 0.18513616919517517, 0.7375273704528809, 0.32692447304725647, -0.28407222032546997, 0.27926528453826904, 0.2572441101074219, 0.39384400844573975, 0.10266498476266861, -0.11004841327667236, -0.30768153071403503, 0.46372169256210327, 0.2395828664302826, 0.5387594103813171, -0.9035562872886658, -0.00007557460048701614, -0.2133278101682663, 0.5745573043823242, 0.3009674847126007, 0.23787634074687958, -0.5413320660591125, 0.4473244249820709, 0.47421160340309143, -0.37142467498779297, -0.25225552916526794, 0.33125317096710205, -0.4028310775756836, -0.4711686074733734, 0.9439254999160767, -0.3568449020385742, -0.2776663601398468, 0.41055092215538025, 0.2149296998977661, 0.7487103939056396, -0.17839518189430237, -0.003043536329641938, -0.6269116997718811, -0.3756110370159149, 0.11876676976680756, -0.08072979748249054, 0.11499650776386261, -0.2730238437652588, 0.003123620757833123, 0.5217077136039734, -0.5175634026527405, 0.08465305715799332, 0.21921472251415253, -0.5236456394195557, 0.1404051035642624, -0.267379492521286, -0.07232827693223953, 0.0008632584940642118, -0.7523495554924011, 0.04710473492741585, -0.27151578664779663, -0.5355154871940613, 0.16242022812366486, 0.11706854403018951, 0.09147394448518753, 0.4635598361492157, 0.34229835867881775, -0.25778645277023315, 0.3727850914001465, -0.5821348428726196, 0.12074108421802521, 0.007842599414288998, -0.05138656869530678, -0.3556085228919983, -0.07196620851755142, 0.4095574617385864, 0.7361888289451599, 0.6277442574501038, 0.19844463467597961, 0.45841675996780396, -0.09296504408121109, 0.5339166522026062, -0.43434348702430725, 0.917747974395752, -1.1477370262145996, 0.09091343730688095, -0.6457705497741699, -0.2357645183801651, 1.0739887952804565, 0.2175574004650116, -0.1764342337846756, -0.3678053915500641, 0.09111393243074417, 0.09918299317359924, 0.28989890217781067, -0.4395573139190674, 0.06741494685411453, 0.03508417308330536, -0.2528577744960785, -0.732844889163971, 0.4891699552536011, -0.11687839031219482, -0.1851596236228943, -0.22393061220645905, 0.40467485785484314, 0.230735182762146, -0.2638223469257355, 0.27143362164497375, 0.0964387059211731, 0.019569071009755135, -0.6723032593727112, 0.4926696717739105, -0.32920557260513306, -0.08987540751695633, -0.5395506024360657, 0.14040379226207733, 0.1709725558757782, -0.6517846584320068, 0.054093290120363235, -0.0034628105349838734, -0.13699878752231598, 0.6050901412963867, -0.02857482247054577, -0.10631901025772095, -0.1370934098958969, -0.7083303332328796, -0.8283290266990662, 0.2900312840938568, 0.05126068368554115, -0.1601816564798355, 0.20589697360992432, -0.21851138770580292, -0.6581469774246216, 0.038006823509931564, 0.06686662882566452, -0.5013395547866821, 0.10999546200037003, 0.2570885717868805 ]
UNLABELLED The objective of this study was to examine differences in cancer survival between socioeconomic groups in England, with particular attention to survival in the short term of follow-up. PATIENTS AND METHODS Individuals diagnosed with colorectal cancer between 1996 and 2004 in England were identified from cancer registry records. Five-year cumulative relative survival and excess death rates were computed. RESULTS For colon cancer there was a very high excess death rate in the first month of follow-up, and the excess death rate was highest in the socioeconomically deprived groups. In subsequent periods, excess mortality rates were much lower and there was less socioeconomic variation. The pattern of variation in excess death rates was generally similar in rectal cancer but the socioeconomic difference in death rates persisted several years longer. If the excess death rates in the entire colorectal cancer patient population were the same as those observed in the most affluent socioeconomic quintile, the annual reduction would be 360 deaths in colon cancer and 336 deaths in rectal cancer patients. These deaths occurred almost entirely in the first month and the first year after diagnosis. CONCLUSION Recent developments in the national cancer control agenda have included an increasing emphasis on outcome measures, with short-term cancer survival an operational measure of variation and progress in cancer control. In providing clues to the nature of the survival differences between socioeconomic groups, the results presented here give strong support for this strategy.
[ 0.009332962334156036, 0.010108357295393944, -0.02297462895512581, 0.024118788540363312, -0.013663588091731071, -0.042448561638593674, 0.01108570583164692, -0.0008978238329291344, -0.015570711344480515, -0.029924921691417694, -0.004137702286243439, 0.012659724801778793, 0.013272793963551521, 0.011798071675002575, -0.0008273739367723465, 0.027749070897698402, -0.02841985411942005, 0.016350198537111282, 0.011395641602575779, 0.025091392919421196, 0.01104279886931181, -0.014142678119242191, 0.010427357628941536, 0.012119618244469166, -0.011129030957818031, 0.023108724504709244, -0.0030076317489147186, 0.021570712327957153, 0.018086843192577362, 0.010746487416327, -0.003943414893001318, 0.02247980609536171, -0.02253059856593609, -0.0024677934125065804, 0.019705666229128838, -0.01505492627620697, 0.0007787698414176702, 0.01233815960586071, -0.01275104284286499, -0.004922025837004185, 0.027293074876070023, -0.01147623360157013, 0.00010856345761567354, -0.011168393306434155, -0.009390282444655895, -0.002456524409353733, -0.010280619375407696, 0.02434368059039116, -0.02818886935710907, 0.013864300213754177, -0.014550693333148956, -0.013635126873850822, -0.023768460378050804, -0.032822854816913605, -0.007598242722451687, -0.02020321972668171, 0.021487509831786156, 0.030924998223781586, -0.025129104033112526, 0.0037541333585977554, 0.009876261465251446, -0.01963105797767639, 0.011500638909637928, 0.000944086816161871, 0.005489598028361797, -0.06687691062688828, 0.003211007220670581, -0.0014503546990454197, -0.010004289448261261, 0.008229333907365799, -0.014333046041429043, 0.009556089527904987, 0.014768866822123528, 0.014985870569944382, -0.042072173207998276, 0.0013531921431422234, 0.008655722253024578, -0.0011505431029945612, 0.007441585883498192, -0.013123538345098495, -0.011259048245847225, 0.0024863313883543015, -0.03044203668832779, 0.023210132494568825, -0.0071218907833099365, 0.005255034193396568, -0.01248442567884922, -0.014745885506272316, 0.006640602834522724, 0.011534093879163265, 0.00044671876821666956, -0.026297640055418015, -0.020852776244282722, -0.0015917755663394928, -0.0114158745855093, -0.016083208844065666, -0.030239470303058624, 0.022023100405931473, -0.006004659458994865, -0.01790044829249382, -0.003561439225450158, -0.0060257394798099995, 0.024432066828012466, 0.008024794049561024, -0.0014974300283938646, 0.012248529121279716, -0.02252282202243805, -0.024984201416373253, 0.003597625531256199, 0.0017497269436717033, -0.00947460439056158, -0.009287232533097267, 0.008359763771295547, -0.039399340748786926, 0.014739226549863815, -0.0004536472260951996, -0.005078772082924843, 0.009836187586188316, 0.005612808279693127, 0.012133483774960041, 0.002943896222859621, -0.008164189755916595, -0.01641085371375084, 0.0015709148719906807, -0.0023919115774333477, 0.03347589075565338, 0.0145577946677804, -0.000535652507096529, -0.01184309832751751, -0.016713611781597137, -0.0076230959966778755, -0.009608620777726173, 0.007831880822777748, 0.001230311580002308, 0.005773331504315138, -0.002252182923257351, 0.003468181472271681, 0.010448834858834743, -0.011819539591670036, -0.004367842338979244, -0.016222797334194183, 0.0070051332004368305, -0.002953561954200268, 0.014816953800618649, -0.019625119864940643, -0.003822814207524061, 0.011028443463146687, 0.003948183264583349, -0.007744647562503815, 0.0052204374223947525, -0.015872392803430557, -0.013220041990280151, 0.015504369512200356, -0.009458567015826702, -0.000534791499376297, -0.017536716535687447, -0.0074957991018891335, -0.02504068985581398, -0.0012620933121070266, -0.01279868371784687, -0.0030622631311416626, 0.011561008170247078, 0.013589075766503811, 0.008425217121839523, 0.019075458869338036, 0.01830519735813141, -0.009859809651970863, -0.013535313308238983, -0.0043124062940478325, 0.004530441015958786, -0.0014903380069881678, 0.0003238767385482788, -0.012348338961601257, 0.01602245680987835, 0.003667582292109728, -0.004783598240464926, 0.011640477925539017, 0.010854070074856281, 0.00932168960571289, 0.06683379411697388, 0.011509210802614689, 0.039959780871868134, -0.007143657188862562, -0.004927493631839752, 0.014144182205200195, 0.005308871623128653, 0.02808704972267151, -0.011854428797960281, -0.006211209110915661, 0.003348803846165538, -0.005361982621252537, 0.04225384071469307, -0.01562788523733616, -0.008780598640441895, 0.008378633297979832, 0.004367861896753311, -0.02384999394416809, -0.005713605787605047, -0.01357864961028099, 0.014574351720511913, -0.005020690616220236, -0.0031251967884600163, 0.01930343545973301, -0.015455985441803932, -0.027652570977807045, 0.01836029440164566, 0.01856936141848564, -0.019294390454888344, 0.02238747850060463, 0.012861521914601326, 0.022821219637989998, -0.015105681493878365, 0.014054475352168083, -0.0002956404350697994, 0.02307317592203617, -0.015979642048478127, 0.003165682777762413, 0.016961317509412766, -0.02665095217525959, -0.02105652540922165, -0.0007141261012293398, 0.002597725484520197, 0.023277239874005318, -0.002450934611260891, 0.007865488529205322, -0.007665232755243778, 0.008103463798761368, 0.010401743464171886, 0.009589442051947117, -0.006263419985771179, -0.003178364597260952, 0.008347047492861748, -0.009417688474059105, -0.01641889289021492, 0.0002637207508087158, 0.0278492271900177, 0.012182412669062614, 0.012183001264929771, 0.007755481172353029, -0.016757097095251083, -0.01814652793109417, 0.019275953993201256, 0.02431706339120865, 0.005539887584745884, 0.04117458313703537, -0.02242865413427353, 0.050462499260902405, -0.005569311790168285, -0.002179536037147045, -0.0037418087013065815, 0.006160794757306576, -0.0047169215977191925, 0.001435765065252781, 0.023359451442956924, 0.004590501543134451, 0.010430516675114632, -0.019304880872368813, -0.002368516754359007, 0.025636965408921242, 0.006112493574619293, 0.02062443271279335, 0.011952124536037445, 0.020916633307933807, -0.011704014614224434, 0.016684798523783684, -0.030371911823749542, -0.024084478616714478, 0.011669222265481949, 0.024489227682352066, 0.017344150692224503, 0.00591370090842247, -0.018050065264105797, 0.011270362883806229, -0.08136502653360367, -0.010776415467262268, -0.0005727778188884258, 0.002172590233385563, 0.011971457861363888, -0.019612710922956467, 0.017071053385734558, 0.01066388376057148, 0.0014764490770176053, -0.0013466812670230865, 0.007817552424967289, 0.017431963235139847, -0.005731259472668171, -0.024226661771535873, 0.009893427602946758, 0.00026037130737677217, 0.0036895766388624907, -0.005659622140228748, -0.023255739361047745, -0.007008773274719715, 0.005032810382544994, 0.003749815747141838, 0.01051497645676136, -0.006244407966732979, 0.008322343230247498, 0.014476120471954346, 0.033158328384160995, 0.01171044260263443, -0.019641682505607605, 0.0017627286724746227, 0.008425318636000156, -0.02318088710308075, 0.004010816104710102, -0.025051195174455643, 0.015832392498850822, 0.005141185596585274, 0.0010590380989015102, 0.020107505843043327, -0.0045475224032998085, 0.016123782843351364, 0.02730926126241684, 0.00922582671046257, 0.002658881712704897, 0.004151822067797184, 0.011157765053212643, -0.008741267025470734, -0.024723438546061516, 0.02692290022969246, 0.01660727709531784, 0.013814620673656464, -0.03286777064204216, -0.01947828009724617, 0.0020057866349816322, 0.01094311848282814, -0.011633316986262798, 0.003974477294832468, -0.002202591858804226, -0.019206572324037552, -0.008755886927247047, -0.013777675107121468, 0.006934626959264278, -0.0027000908739864826, 0.007116568740457296, 0.025630410760641098, 0.008031290024518967, -0.026728227734565735, 0.006723853759467602, -0.007123325020074844, -0.02526864968240261, 0.00030567729845643044, 0.0047829546965658665, -0.017732709646224976, 0.01899717003107071, -0.02249971032142639, 0.01597810536623001, -0.007555800955742598, -0.015083525329828262, 0.0007874298607930541, 0.023351790383458138, 0.009209338575601578, -0.008266579359769821, -0.02064467780292034, -0.003839651122689247, 0.017667921259999275, -0.012981751002371311, -0.007547994144260883, 0.01692432351410389, 0.011028465814888477, 0.025219134986400604, -0.021854184567928314, 0.021708164364099503, -0.0015950070228427649, 0.021924981847405434, 0.014813248068094254, 0.023655714467167854, -0.019360240548849106, 0.014023123309016228, 0.006137845106422901, 0.010098041966557503, 0.010458383709192276, -0.01081943605095148, -0.006521971896290779, -0.014861684292554855, -0.015236373990774155, -0.001688994700089097, 0.011991556733846664, 0.01233664806932211, 0.014223323203623295, -0.013550443574786186, -0.005531215108931065, -0.011115921661257744, -0.020437760278582573, -0.0037939357571303844, 0.035253092646598816, 0.014636566862463951, -0.009910741820931435, 0.01206454262137413, -0.013226913288235664, 0.07164338231086731, 0.002879413543269038, 0.016421860083937645, -0.005266566760838032, 0.01784256100654602, -0.018555114045739174, -0.035713180899620056, 0.0020494339987635612, -0.012486511841416359, -0.004051349125802517, 0.0134038170799613, 0.027131663635373116, 0.004835235886275768, -0.0118989497423172, 0.010190175846219063, 0.021507054567337036, -0.0003460845910012722, 0.00917558092623949, -0.0025896108709275723, -0.03265047073364258, -0.042562201619148254, 0.01788296177983284, -0.026606064289808273, -0.007733466103672981, 0.021386902779340744, -0.028231702744960785, 0.009518519975244999, -0.01583050563931465, -0.013110164552927017, 0.0024011058267205954, 0.003012680448591709, 0.020649908110499382, -0.006755352020263672, 0.006165801547467709, 0.009723177179694176, 0.03493288904428482, 0.001516516786068678, 0.014384719543159008, 0.006390562281012535, -0.0036937780678272247, -0.02683122828602791, -0.01297147385776043, 0.003874805523082614, 0.009237146005034447, -0.022264201194047928, 0.017110133543610573, 0.034519217908382416, -0.006391170434653759, -0.0032964989077299833, 0.030208539217710495, 0.0032433168962597847, 0.00783773884177208, 0.007760760374367237, -0.008693667128682137, -0.022930314764380455, -0.007124452386051416, -0.014695562422275543, 0.003903043922036886, -0.0039378441870212555, 0.0035715866833925247, 0.003561098128557205, -0.024835824966430664, 0.00014455337077379227, 0.02284901961684227, -0.019400669261813164, -0.0038777110166847706, 0.002794504864141345, -0.005363481119275093, -0.007934738881886005, -0.00183522654697299, 0.0017024410190060735, 0.008648611605167389, -0.021510915830731392, 0.0035377778112888336, 0.01111653819680214, 0.0180476326495409, -0.023286212235689163, 0.00008737016469240189, -0.005327040329575539, -0.015498856082558632, -0.027228856459259987, -0.013761122711002827, 0.020519405603408813, -0.015396680682897568, -0.00522941630333662, -0.003129980992525816, -0.02602665312588215, -0.07427690178155899, -0.029850291088223457, 0.005468941293656826, -0.01041354052722454, -0.01352909579873085, 0.009023047983646393, -0.012943059206008911, 0.02162342518568039, -0.023468507453799248, -0.0017986551392823458, -0.010831642895936966, 0.002745618112385273, -0.039399340748786926, -0.012937710620462894, 0.01961742714047432, 0.0006069212686270475, 0.017825109884142876, -0.0025873645208775997, -0.01325959898531437, 0.016050539910793304, 0.03808271139860153, 0.030464958399534225, 0.004063420929014683, -0.018842343240976334, -0.00947489496320486, -0.08048155903816223, 0.016694325953722, -0.019236335530877113, -0.01650344394147396, -0.007269886787980795, -0.020141134038567543, 0.004097680561244488, -0.025758910924196243, -0.01645488478243351, -0.015378891490399837, -0.029985636472702026, -0.003765619359910488, 0.02627629227936268, -0.004478983581066132, -0.0030905832536518574, -0.002461296273395419, 0.024692609906196594, -0.03690827637910843, -0.015687614679336548, -0.006769824307411909, 0.012513840571045876, 0.004804866388440132, -0.000921114522498101, 0.00755359698086977, -0.007049654610455036, -0.0030344107653945684, -0.006200666539371014, 0.0008369251736439764, 0.01925421506166458, -0.001448238966986537, 0.0267832912504673, -0.003824479877948761, -0.0053116315975785255, -0.030813176184892654, -0.00569860590621829, -0.02279547229409218, -0.011596188880503178, -0.004597598686814308, 0.005452937446534634, 0.0025559409987181425, -0.004039170686155558, 0.0034009739756584167, 0.01554565317928791, -0.0049933032132685184, 0.01086562778800726, -0.009751160629093647, 0.0096123730763793, -0.01124909520149231, 0.01064387522637844, -0.0035416926257312298, 0.0074036442674696445, -0.03510979562997818, -0.008172097615897655, -0.0006367325549945235, -0.02967388555407524, -0.021525880321860313, -0.011560690589249134, -0.011411825194954872, 0.018357418477535248, 0.010619906708598137, 0.013436263427138329, -0.007624273654073477, -0.02219952456653118, 0.07171741127967834, -0.008625371381640434, 0.017635200172662735, 0.013569348491728306, -0.0026490208692848682, -0.0010935734026134014, -0.02051844820380211, 0.005650005768984556, 0.002356535755097866, -0.020023511722683907, 0.008341365493834019, -0.0006011249497532845, 0.0022415639832615852, 0.007596803829073906, 0.006081219296902418, -0.0020333132706582546, 0.03515683859586716, 0.025525476783514023, -0.0048707034438848495, -0.01635470613837242, -0.021076546981930733, 0.02423030510544777, -0.010780906304717064, 0.013426519930362701, 0.0022479696199297905, -0.0013722025323659182, -0.0022719567641615868, 0.0023385342210531235, 0.014050101861357689, 0.011919726617634296, -0.015103469602763653, 0.013253767974674702, 0.013256603851914406, 0.0024348879233002663, 0.032349634915590286, -0.005363598465919495, 0.004408946260809898, 0.009826493449509144, -0.020690375939011574, -0.0036289002746343613, 0.03501170873641968, 0.008858215063810349, 0.013786950148642063, -0.030967775732278824, 0.012569913640618324, 0.009642189368605614, -0.004322176333516836, 0.001478087855502963, -0.03229370713233948, 0.016005849465727806, 0.01081111654639244, 0.009748747572302818, -0.01259644515812397, -0.006972058676183224, -0.02465033531188965, -0.00640503503382206, -0.0055272579193115234, 0.024278361350297928, 0.025729965418577194, -0.025457173585891724, -0.011377004906535149, -0.0122868986800313, -0.0024600746110081673, -0.01430756039917469, 0.01041517872363329, -0.009504009038209915, 0.02221572771668434, -0.015656087547540665, -0.0329151526093483, 0.013497482985258102, 0.01955351233482361, -0.008688896894454956, 0.00708048976957798, -0.020093455910682678, 0.0002813037717714906, -0.01706322468817234, 0.028689267113804817, 0.017754225060343742, -0.005622507072985172, 0.021123021841049194, -0.008282236754894257, 0.024131370708346367, -0.00585522223263979, -0.028993280604481697, -0.04851286858320236, 0.020586242899298668, 0.023807348683476448, -0.0032240175642073154, -0.016090985387563705, 0.0023534661158919334, 0.01397801749408245, 0.007732906378805637, -0.001256095594726503, 0.012950096279382706, 0.014639152213931084, 0.035637229681015015, -0.0010266066528856754, -0.0019706489983946085, 0.019533004611730576, -0.01029308419674635, -0.014053592458367348, -0.0038536074571311474, -0.003957254812121391, -0.02039782702922821, 0.000379723496735096, -0.010362120345234871, 0.006748742889612913, 0.0018923007883131504, 0.01795361191034317, 0.012422862462699413, 0.017359891906380653, -0.020282091572880745, 0.03596613183617592, 0.004917904734611511, 0.005945855751633644, 0.014395289123058319, -0.012417572550475597, -0.008166264742612839, 0.015196291729807854, -0.017198413610458374, -0.003770500421524048, -0.015495823696255684, -0.02642250433564186, 0.00603306433185935, 0.023655131459236145, -0.012637918815016747, -0.007778234779834747, -0.012557975016534328, 0.004240366630256176, 0.009499981068074703, -0.002881410298869014, -0.009363068267703056, 0.020067693665623665, 0.0015861729625612497, -0.017443832010030746, -0.00021830806508660316, 0.017234288156032562, 0.021094098687171936, -0.01989334262907505, 0.0006889698561280966, 0.021968306973576546, 0.002042722422629595, 0.00585068017244339, -0.02134108543395996, 0.010402817279100418, 0.008125142194330692, 0.007933059707283974, -0.0001069502905011177, 0.016232740134000778, -0.01119980588555336, 0.0029920462984591722, 0.00972720142453909, 0.013316577300429344, -0.00258156331256032, -0.0034133538138121367, 0.0019569233991205692, 0.01052423007786274, 0.016573183238506317, 0.019869361072778702, -0.006046005059033632, -0.01716955378651619, -0.044024113565683365, -0.006954064592719078, -0.0025497504975646734, -0.010045597329735756, 0.00892683956772089, -0.013183590024709702, 0.005869111977517605, -0.00010900292545557022, -0.006301152054220438, -0.014309193007647991, -0.022321190685033798, 0.014608114957809448, 0.016934655606746674, -0.02796180732548237, 0.0011818353086709976, 0.010055670514702797, -0.004741128534078598, -0.022069087252020836, -0.006447162013500929, -0.008200624957680702, 0.016850262880325317, 0.007053781766444445, -0.012649394571781158, -0.0021096477285027504, 0.02426028996706009, -0.010300436988472939, 0.03144877403974533, -0.006726844236254692, 0.003655971959233284, 0.0027549141086637974, -0.009363392367959023, -0.02988840825855732, 0.011443511582911015, -0.0037343017756938934, 0.017006810754537582, 0.00010816473513841629, 0.008382091298699379, -0.00945033598691225, 0.001448844326660037, 0.0019353590905666351, -0.020811516791582108 ]
[ 0.20274966955184937, -0.25705772638320923, 0.4465560019016266, -0.40932121872901917, 0.3727078139781952, 0.5044592618942261, 0.14409002661705017, 0.07165346294641495, -0.2648879587650299, -0.009543155319988728, 0.019893744960427284, -0.03507300838828087, 0.1346459686756134, 0.4712247848510742, -0.20088911056518555, 0.5582140684127808, 0.6958671808242798, -0.00918943714350462, -0.016478225588798523, -0.4022550582885742, 0.016667909920215607, -0.5037967562675476, 0.08429733663797379, -0.05467270687222481, -0.024555182084441185, -0.06495295464992523, 0.4464035928249359, -0.5986746549606323, -0.41971448063850403, 0.13650435209274292, -0.38886815309524536, 0.2531813681125641, 0.5557624101638794, -0.5477701425552368, 0.1492472141981125, 0.11677677184343338, 0.02265949919819832, 0.07862253487110138, -0.15391726791858673, -0.6017559766769409, -0.2953140437602997, 0.16942229866981506, 0.12957800924777985, 0.29347649216651917, -0.31363850831985474, 0.23509275913238525, -1.0238831043243408, 0.3556991517543793, 0.05969424173235893, 0.30409401655197144, 0.056261155754327774, -0.3798266649246216, 0.22692984342575073, 0.002470362465828657, 0.041784584522247314, -0.004281709436327219, 0.03054727613925934, -0.05820939689874649, 0.00873053539544344, -0.21882149577140808, 0.6184158325195312, -0.09472160786390305, 0.09703280031681061, 0.17590004205703735, -0.16065390408039093, 0.37313586473464966, 0.009799656458199024, 0.29315394163131714, 0.02560555748641491, -0.32421553134918213, 0.4096109867095947, -0.19556066393852234, -0.21053549647331238, 0.3388417363166809, -0.32909873127937317, 0.24794761836528778, 0.10420068353414536, -0.3103094696998596, 0.5225236415863037, -0.031145192682743073, 0.2218269258737564, -0.5079959630966187, 0.22755400836467743, -0.03507420793175697, 0.4507533013820648, -0.18030570447444916, -0.14645391702651978, 0.4068155586719513, -0.03478807210922241, 0.14988981187343597, 0.0721096619963646, 0.07914049923419952, 0.4971151649951935, 0.357585608959198, 0.057594142854213715, 0.33445703983306885, -0.08956214785575867, -0.2449817955493927, 0.27613818645477295, -0.2909618020057678, -0.4850522577762604, 0.4076962471008301, 0.10781067609786987, -0.2087361216545105, -0.5304281711578369, -0.03689875453710556, -0.07259219139814377, -0.3344060480594635, -0.3742827773094177, -0.06861275434494019, -0.39907053112983704, 0.24142266809940338, -0.22539296746253967, 0.12074608355760574, -0.33674442768096924, 0.6313468813896179, 0.2510531544685364, -0.40428170561790466, 0.1545892059803009, -0.0632215291261673, -0.21955181658267975, 0.603547215461731, -0.34867754578590393, -0.08061474561691284, -0.0965392217040062, 0.09661053121089935, 0.43740609288215637, 0.06730280816555023, -0.5334930419921875, 0.4156164228916168, -0.19984745979309082, 0.7025980949401855, -0.42749670147895813, -0.16994871199131012, 0.21065965294837952, -0.3174290060997009, -0.1883615255355835, 0.24109159409999847, 0.3944312632083893, 0.34491780400276184, -0.36187535524368286, -0.2531890273094177, -0.3831958770751953, 0.3424621820449829, 0.1907673329114914, -0.364849328994751, 0.3193141520023346, 0.08856011182069778, -0.5035862326622009, -0.10479115694761276, 0.1371021568775177, -0.009978368878364563, -0.01509992778301239, -0.45818665623664856, -0.14046388864517212, 0.3986811637878418, -0.23232612013816833, -0.1337548941373825, 0.16321183741092682, -0.2295103371143341, 0.3900279998779297, 0.07085832208395004, 0.33436882495880127, 0.10719595849514008, 0.1531447023153305, 0.15840581059455872, 0.06339327245950699, -0.12070435285568237, -0.12277555465698242, 0.24010933935642242, -0.5769092440605164, -0.4294263422489166, 0.5197458863258362, -0.33427733182907104, -0.062328796833753586, -0.03131379932165146, 0.19025824964046478, 0.4264567792415619, 0.0912565141916275, 0.10877946764230728, -0.5840926766395569, -0.08607765287160873, 0.005670386832207441, -0.3302063047885895, -0.005292919930070639, -0.17523734271526337, 0.1936003416776657, 0.46401718258857727, 0.4289984107017517, 0.6885918974876404, 0.0006472010863944888, -0.4500989615917206, 0.4923115074634552, -0.7306200861930847, 0.9640395045280457, 0.04799091815948486, 0.025771571323275566, 1.0887399911880493, -0.33297815918922424, 0.1750553399324417, 0.2435419261455536, 0.3337063193321228, 0.797853946685791, -0.13177935779094696, -0.36524441838264465, -0.15400059521198273, 0.2648577392101288, -0.4166310131549835, 0.11757384240627289, 0.03429942578077316, 0.09827987104654312, -0.26576682925224304, -0.25042617321014404, 0.3753288984298706, 0.058662258088588715, 0.036184173077344894, 0.2400929033756256, -0.10894113034009933, 0.3994128704071045, -0.6085425019264221, 0.42871594429016113, 0.004630374256521463, 0.6549256443977356, 0.1257224678993225, 0.19579051434993744, 0.8957324624061584, -0.003651275997981429, -0.2402999848127365, 0.7991775870323181, -0.33288657665252686, -0.15541361272335052, 0.4764448404312134, 0.17240113019943237, -0.37448787689208984, 0.06936325132846832, 0.2576512098312378, -0.09723950177431107, -0.2804229259490967, 0.17672443389892578, -0.02673114649951458, 0.5379168391227722, -0.35917288064956665, -0.4391973316669464, 0.1906629502773285, 0.15286284685134888, 0.0027934974059462547, -0.11956589668989182, 0.17348690330982208, -0.37807855010032654, -0.2586078643798828, 0.23916438221931458, 0.1497526615858078, -0.284868985414505, -0.26802322268486023, 0.36140498518943787, 0.40871965885162354, -0.18557149171829224, -0.2294054925441742, 0.0857962816953659, -0.10598710179328918, -0.4207617938518524, 0.4179189205169678, 0.24129952490329742, 0.008290884084999561, 0.22264359891414642, -0.4193134605884552, -1.201294183731079, -0.7079684138298035, 1.0264368057250977, 0.3430428206920624, 0.5449343323707581, 0.4284118115901947, -0.8417009115219116, 0.21308709681034088, -0.009724849835038185, 0.01406922284513712, -0.2535930871963501, 0.6632123589515686, 0.052783288061618805, -0.4265102446079254, 0.04996425658464432, 0.38514184951782227, 0.6919505596160889, -0.41382521390914917, 0.09946098178625107, -0.036716535687446594, -0.2806711494922638, -0.2012576460838318, -0.26726678013801575, -0.18196958303451538, -0.3785100281238556, 0.4531855583190918, -0.2268490046262741, -0.1812673658132553, 0.01756102405488491, -0.06025601923465729, -0.22114524245262146, -0.04905088618397713, 0.627314031124115, 0.16643628478050232, -0.4671564996242523, 0.1700567603111267, -0.5134156346321106, -0.48811495304107666, -0.07803595066070557, -0.16509407758712769, -0.47996872663497925, -0.4652685225009918, -6.265031337738037, 0.3939380943775177, -0.16538016498088837, -0.2275805026292801, 0.2494150996208191, 0.11526058614253998, 0.1950846016407013, 0.217172771692276, 0.11465003341436386, -0.14969821274280548, 0.5653950572013855, 0.39542192220687866, 0.12950286269187927, 0.46075674891471863, 0.2440190315246582, -0.027127964422106743, 0.06324146687984467, -0.37867602705955505, 0.23646292090415955, -0.5106899738311768, 0.1288607269525528, -0.03712598234415054, 0.24436229467391968, 0.06508105248212814, 0.12552736699581146, 0.9921277761459351, -0.7491083741188049, 0.5173019170761108, -0.3333531618118286, -0.571994960308075, 0.25235918164253235, -0.1330261081457138, 0.005708106327801943, -0.08213375508785248, -0.007364967372268438, 0.2010052502155304, 0.05683605745434761, 0.08572061359882355, -0.10154794156551361, -0.7306699156761169, -0.04329511150717735, -0.14965522289276123, -0.8533218502998352, -0.2558962106704712, 0.13983161747455597, 0.07176300883293152, -0.005853624083101749, 0.07962243258953094, -0.015031319111585617, 0.07989625632762909, -0.05898628011345863, 0.227263942360878, 0.2836272716522217, 0.3569129407405853, -0.16637495160102844, -0.0864422395825386, -0.7111696004867554, 0.17417192459106445, -0.4886978566646576, 0.11984945088624954, -0.4728908836841583, -0.10463863611221313, 0.024267947301268578, -0.6057811975479126, -0.21395133435726166, 0.10369747877120972, -0.3130967617034912, 0.007482497021555901, 0.46952125430107117, 0.023341357707977295, -0.20593279600143433, 0.08249460905790329, 0.5945746302604675, -0.5400832891464233, 0.18608705699443817, -0.13947650790214539, 0.5491278171539307, -0.23592454195022583, -0.05813033506274223, -0.263614684343338, -0.18956612050533295, -0.046719472855329514, 0.1407439112663269, 0.16735807061195374, -0.03350893035531044, -0.4505215883255005, 0.038118451833724976, 0.26488515734672546, -0.20699149370193481, 0.047610387206077576, 0.44786936044692993, -0.3064102530479431, 0.1818477064371109, 0.4438851475715637, 0.18429447710514069, 0.608003556728363, 0.24865171313285828, 0.11178930848836899, 0.17657099664211273, 0.12589825689792633, 0.5617380142211914, 0.06591498106718063, -0.5216474533081055, -1.052633285522461, -0.34809258580207825, -0.3841427266597748, -0.7917764186859131, -0.13682523369789124, 0.208110049366951, -0.9571079015731812, 0.3064722716808319, -0.11903977394104004, -0.44534027576446533, 0.01015472412109375, 0.07388521730899811, -0.3606702387332916, 0.1949358731508255, -0.17152318358421326, 0.8375252485275269, -0.12805162370204926, 0.30616840720176697, -0.0058481586165726185, 0.1651538908481598, 0.16219164431095123, 0.08752478659152985, 0.13134895265102386, 0.4895712733268738, 0.4168529510498047, -0.7359170317649841, 0.4438500702381134, 0.1100938469171524, 0.5224120020866394, -0.47430625557899475, -0.29995059967041016, 0.23688405752182007, -0.2315492033958435, -0.5913962721824646, 0.31381237506866455, -0.07641486078500748, 0.38690468668937683, 0.5589818358421326, -0.1382569968700409, 0.2981472611427307, 0.377409428358078, -0.11411914974451065, -0.3190148174762726, 0.012270190753042698, -0.11073294281959534, 0.0798482596874237, -0.0688835009932518, 0.19771645963191986, 0.04193782061338425, 0.49178799986839294, -0.4003589451313019, -0.18567079305648804, 0.19849619269371033, 0.13862255215644836, -0.012245805002748966, -0.37739837169647217, -0.20832698047161102, -0.12052424252033234, 0.18927335739135742, -0.8225151896476746, -0.08663389086723328, 0.005760551895946264, -0.5887873768806458, 0.05196234956383705, 0.05837995558977127, 0.40583667159080505, 0.10054608434438705, 0.010713540948927402, -0.6877418756484985, 0.07404235005378723, 0.424791544675827, 0.3899323046207428, 0.25925761461257935, -0.2480425387620926, -0.11433538794517517, 0.09236466884613037, 0.3050456941127777, 0.1447523683309555, -0.44233253598213196, -0.5213414430618286, 0.5694653987884521, 1.0836687088012695, 0.46647346019744873, -0.5475860834121704, -0.5063380002975464, -0.15150493383407593, -0.0792393758893013, 0.12293088436126709, -0.0035165927838534117, 0.5212018489837646, 0.19947732985019684, -0.5171298980712891, -0.23142695426940918, 0.04349062591791153, 0.1713026612997055, 0.18650980293750763, -0.11013028770685196, -0.03860502690076828, 0.1949634552001953, -0.186201274394989, -0.15105773508548737, 0.2822117805480957, -0.5607824921607971, -0.39589226245880127, -0.2879270613193512, -0.3288255035877228, -0.11000262945890427, -0.0485883392393589, -0.3180757462978363, -0.05116265267133713, 0.7071934938430786, -0.41256850957870483, 0.1618807315826416, -0.4391275942325592, -0.35500937700271606, 0.038876574486494064, 0.18696695566177368, 0.38128408789634705, -0.032246362417936325, -0.28872111439704895, 0.13465556502342224, -0.37845516204833984, 0.06409882754087448, 0.2661476135253906, -1.0226482152938843, -0.12288369238376617, 0.14354024827480316, -0.30210617184638977, 0.02440761961042881, -0.2292681485414505, 0.05232198163866997, 0.000527825322933495, -0.030860038474202156, 0.13032647967338562, -0.4265076518058777, -0.36596783995628357, 0.23740731179714203, 0.3270636796951294, 0.19923140108585358, -0.11417725682258606, -0.6912779211997986, -0.18664267659187317, 0.2785852253437042, 0.010319327004253864, -0.6479482054710388, -0.05018433928489685, 0.3222047984600067, 0.23529648780822754, -0.23349526524543762, 0.4599650204181671, -0.5322649478912354, 0.8568932414054871, 0.34630993008613586, 0.4635354280471802, -0.7123336791992188, 0.1227356344461441, -0.004285009577870369, 0.12049037218093872, -0.03846528008580208, -0.0317072756588459, 0.030358536168932915, 0.12364057451486588, 0.016343852505087852, -0.07845860719680786, -0.4686143398284912, 0.22316330671310425, -0.5277327299118042, -0.12187112122774124, 0.1847924292087555, 0.14913037419319153, 0.4339832663536072, -0.023258188739418983, 0.41407153010368347, 0.07298198342323303, 0.24013374745845795, -0.08633933216333389, 0.32381704449653625, -0.5024107694625854, -0.40101274847984314, 0.2768518030643463, -0.20975153148174286, -0.08195631951093674, -0.2567097246646881, 0.22579146921634674, -0.02101120539009571, -0.02113218605518341, -0.520226240158081, 0.09065550565719604, -0.32600176334381104, -0.46563443541526794, -0.36670175194740295, 0.1361604928970337, 0.02903272584080696, -0.12675359845161438, 0.5217583179473877, 0.21036435663700104, -0.4790501892566681, -0.47065192461013794, 0.2529163956642151, 0.140556201338768, -0.21156243979930878, 0.33130553364753723, 0.6275448203086853, 0.670320987701416, 0.08318866789340973, -0.2877792418003082, -0.394664466381073, 0.4458606243133545, 0.006701245903968811, 0.10621007531881332, 0.6557745337486267, -0.6468909978866577, -0.3453048765659332, -0.5922351479530334, -0.2836824655532837, -0.027897389605641365, 0.23992903530597687, 0.08868567645549774, 0.7221749424934387, 0.3294028639793396, 0.016602857038378716, -0.27225708961486816, 0.506400465965271, 0.23315471410751343, 0.2048107236623764, -0.026925373822450638, 0.05200160667300224, 0.404887318611145, 0.44983014464378357, -0.12044024467468262, 0.5338464379310608, 0.06428733468055725, 0.290750652551651, -0.23130764067173004, -0.3143581449985504, -0.09966923296451569, 0.31695476174354553, 0.5959977507591248, 0.1829945594072342, -0.07916621118783951, -0.39933785796165466, -0.26411256194114685, 0.6608782410621643, -0.5010387897491455, -0.11263682693243027, 0.46459850668907166, 0.13533636927604675, 0.14161396026611328, 0.07162770628929138, -0.23164045810699463, 0.4261479377746582, -0.6497645378112793, -0.10835319012403488, 0.43294888734817505, -0.14334268867969513, -0.30365046858787537, 0.08838628232479095, 0.0009081337484531105, 0.14154672622680664, -0.6387572884559631, 0.493935763835907, -0.12222052365541458, -0.4047602713108063, 0.3148208558559418, 0.010142347775399685, -0.2062627524137497, 0.07079735398292542, 0.511608362197876, 0.01867220550775528, -0.5177263617515564, -0.2214130014181137, -0.04777109622955322, -0.38890644907951355, 0.1473851203918457, 0.07759509980678558, -0.1863529533147812, -0.11719883978366852, -0.29947429895401, -0.022552601993083954, 0.04574074223637581, -0.5270857810974121, 0.028721418231725693, -0.38850143551826477, -0.464956134557724, 0.20641592144966125, -0.1241210550069809, 0.1272175908088684, 0.018048230558633804, -0.40604522824287415, 0.052002474665641785, 0.09186800569295883, -0.3039444386959076, -0.5422914624214172, 0.04524165019392967, -0.11125919222831726, 0.412939190864563, 0.16109409928321838, -0.010502522811293602, 0.05391976237297058, 0.12429359555244446, 0.4361126720905304, -0.7065746188163757, 0.6100724339485168, -0.6064417362213135, -0.219959557056427, -0.13867104053497314, 0.49930644035339355, 0.3771899938583374, 0.4061602056026459, -0.4178014099597931, 0.13029521703720093, -0.30855169892311096, -0.020827004685997963, 0.3184986412525177, -0.2313321828842163, -0.24627012014389038, 0.03344547376036644, -0.5300427675247192, -0.38710466027259827, 0.07295755296945572, 0.1170925572514534, -0.18557853996753693, -0.40810543298721313, 0.5600213408470154, 0.4239988923072815, 0.04509206488728523, 0.8909780383110046, -0.34551548957824707, -0.08308058232069016, -0.5130600929260254, -0.2662530541419983, -0.7551905512809753, 0.059442710131406784, 0.13201475143432617, 0.11918955296278, -0.4781912565231323, 0.0035889153368771076, -0.18327200412750244, -0.2273106575012207, 0.1956304907798767, -0.13951507210731506, 0.45295611023902893, 0.24165454506874084, 0.5968157052993774, -0.36730900406837463, -0.5459327101707458, 0.37688639760017395, 0.1075705885887146, 0.1677301973104477, 0.23670466244220734, -0.3123708963394165, 0.08451950550079346, 0.12002784758806229, -0.22269725799560547, -0.2626311480998993, -0.2996671199798584, 0.2549716830253601 ]
Cell-to-cell adhesions are crucial in maintaining the structural and functional integrity of cardiac cells. Little is known about the mechanosensitivity and mechanotransduction of cell-to-cell interactions. Most studies of cardiac mechanotransduction and myofibrillogenesis have focused on cell-extracellular matrix (ECM)-specific interactions. This study assesses the direct role of intercellular adhesion, specifically that of N-cadherin-mediated mechanotransduction, on the morphology and internal organization of neonatal ventricular cardiac myocytes. The results show that cadherin-mediated cell attachments are capable of eliciting a cytoskeletal network response similar to that of integrin-mediated force response and transmission, affecting myofibrillar organization, myocyte shape, and cortical stiffness. Traction forces mediated by N-cadherin were shown to be comparable to those sustained by ECM. The directional changes in predicted traction forces as a function of imposed loads (gel stiffness) provide the added evidence that N-cadherin is a mechanoresponsive adhesion receptor. Strikingly, the mechanical sensitivity response (gain) in terms of the measured cell-spread area as a function of imposed load (adhesive substrate rigidity) was consistently higher for N-cadherin-coated surfaces compared with ECM protein-coated surfaces. In addition, the cytoskeletal architecture of myocytes on an N-cadherin adhesive microenvironment was characteristically different from that on an ECM environment, suggesting that the two mechanotransductive cell adhesion systems may play both independent and complementary roles in myocyte cytoskeletal spatial organization. These results indicate that cell-to-cell-mediated force perception and transmission are involved in the organization and development of cardiac structure and function.
[ -0.017305582761764526, 0.01920105516910553, -0.018245495855808258, 0.014084974303841591, 0.021337850019335747, -0.006063623353838921, 0.012090949341654778, -0.00794022623449564, -0.015292733907699585, -0.014432192780077457, -0.01174389012157917, 0.017941702157258987, -0.015719711780548096, 0.02570422925055027, -0.01599741540849209, 0.004321676678955555, -0.003698202781379223, 0.010493501089513302, 0.005175858736038208, -0.011447759345173836, -0.010397957637906075, -0.004447460174560547, 0.011682412587106228, -0.005635275971144438, 0.011405820958316326, 0.02437708154320717, 0.020808227360248566, -0.010979988612234592, 0.01789671927690506, 0.005785181187093258, -0.019831033423542976, 0.008096960373222828, 0.010769173502922058, 0.01534691359847784, 0.008187767118215561, 0.008554467931389809, 0.000845932518132031, 0.03310510888695717, 0.02123587392270565, -0.005656788125634193, 0.024474766105413437, -0.008998779579997063, 0.00484106782823801, -0.0022325520403683186, -0.007391044870018959, -0.005035605281591415, -0.00013700334238819778, 0.007666625082492828, -0.01891942135989666, 0.012280992232263088, -0.0021997278090566397, -0.0448288731276989, -0.004898115061223507, 0.0028886368963867426, -0.007555933203548193, 0.004694606177508831, 0.02059171162545681, -0.04485677182674408, -0.003882866818457842, 0.0055575245060026646, 0.011773445643484592, -0.03193969652056694, 0.007734620478004217, -0.021692071110010147, 0.016333695501089096, -0.0662464052438736, 0.023433446884155273, 0.01787899062037468, 0.001709507778286934, 0.012208778411149979, -0.002881541382521391, 0.006243068724870682, -0.0011781086213886738, 0.010068058036267757, 0.024431636556982994, 0.00037797214463353157, -0.015072209760546684, 0.018768470734357834, 0.021468715742230415, 0.0008769483538344502, 0.003685436910018325, -0.006234420463442802, 0.010164007544517517, 0.014994878321886063, 0.0245806947350502, 0.002221866277977824, -0.0286389272660017, 0.0035286208149045706, 0.03102884814143181, -0.00515338871628046, -0.011477697640657425, 0.027286754921078682, 0.002023212146013975, -0.013793515041470528, 0.03349337726831436, 0.020564310252666473, 0.01541727501899004, -0.0030521871522068977, 0.011674047447741032, 0.036895595490932465, -0.01731656864285469, -0.011203629896044731, 0.02216155081987381, -0.002885754220187664, 0.0006057136924937367, 0.007789495401084423, 0.03454955667257309, 0.01948283240199089, 0.015213584527373314, 0.016092553734779358, 0.002929123118519783, 0.009150679223239422, -0.0039614480920135975, 0.011857056058943272, 0.014340279623866081, -0.0122409388422966, -0.021139323711395264, -0.001301613636314869, 0.01460852287709713, -0.016165660694241524, 0.022777028381824493, -0.003059152513742447, 0.010096008889377117, 0.004996920470148325, 0.004962647799402475, -0.001972614787518978, -0.02298910915851593, 0.01006658561527729, -0.01588134840130806, 0.01884591020643711, -0.009596338495612144, 0.021210255101323128, 0.015360912308096886, -0.005395437125116587, 0.006625741720199585, -0.000011962256394326687, -0.014916346408426762, -0.0027840842958539724, -0.0020062269177287817, -0.024127056822180748, 0.014618882909417152, 0.010868842713534832, 0.004266806878149509, 0.0059294747188687325, 0.0059912800788879395, 0.006037657614797354, -0.017757991328835487, 0.004399658180773258, 0.004729496780782938, 0.007986248470842838, 0.0046481778845191, 0.01566057652235031, -0.02334163524210453, -0.015033924952149391, -0.007057340815663338, -0.01928200200200081, 0.0004064682871103287, -0.008340677246451378, -0.00877972412854433, 0.004666684195399284, -0.031245416030287743, -0.02608964778482914, 0.016874238848686218, 0.011605536565184593, 0.01288069598376751, 0.003954359330236912, 0.022511480376124382, -0.01521699596196413, -0.02455417811870575, 0.00958654098212719, -0.0115243224427104, 0.01212315447628498, -0.021097533404827118, 0.00812576524913311, 0.0254594087600708, -0.003459153464064002, 0.009069250896573067, 0.00601939344778657, -0.027177218347787857, 0.06609153747558594, -0.006134297698736191, 0.026009857654571533, 0.015600762329995632, -0.026386527344584465, -0.001709971111267805, -0.011944083496928215, -0.0045194076374173164, -0.011341074481606483, -0.00375400111079216, -0.02728789858520031, 0.0034173820167779922, -0.04019807279109955, -0.0054249148815870285, -0.011356748640537262, -0.022607993334531784, 0.0034344277810305357, 0.023558976128697395, 0.0027790511958301067, -0.00934340339154005, -0.041004788130521774, -0.016913820058107376, -0.03907815366983414, 0.0124766044318676, -0.021395502611994743, 0.009416608139872551, 0.009965424425899982, 0.016461513936519623, 0.015607191249728203, -0.03129638358950615, 0.005869085900485516, 0.017854738980531693, 0.013133937492966652, -0.011232313700020313, -0.00732227461412549, 0.029148465022444725, 0.003324649529531598, -0.016937987878918648, 0.022748885676264763, -0.01832335814833641, -0.014058766886591911, -0.0026572803035378456, 0.016201548278331757, 0.0146997831761837, 0.017392907291650772, 0.03867845609784126, 0.006955675780773163, -0.007720196153968573, 0.01074726041406393, 0.012268919497728348, 0.007848777808248997, -0.04653521627187729, -0.008792952634394169, -0.013441569171845913, -0.0221896693110466, 0.01768500544130802, -0.020444795489311218, 0.014125666581094265, -0.006236829794943333, 0.021898513659834862, -0.010710718110203743, -0.006675417069345713, -0.0052554854191839695, 0.020072579383850098, -0.02457551285624504, 0.03620029240846634, 0.027005426585674286, -0.018522163853049278, 0.007506359368562698, 0.009737160988152027, -0.019442545250058174, 0.011034736409783363, -0.0012946315109729767, 0.006228728219866753, 0.011871617287397385, -0.019114069640636444, -0.02795380726456642, 0.0374143049120903, 0.009431430138647556, 0.028377380222082138, 0.022378314286470413, -0.0003966907970607281, 0.008448879234492779, -0.008553078398108482, 0.011679548770189285, -0.015483085997402668, -0.009360435418784618, 0.010832112282514572, 0.0063246916979551315, -0.001975914230570197, -0.007548736874014139, 0.005278019234538078, -0.001646846649236977, -0.004746212624013424, -0.08127930015325546, -0.01605602353811264, -0.02621583640575409, 0.012657125480473042, 0.002590722404420376, -0.0076863388530910015, 0.01487311813980341, -0.0016164681874215603, 0.0007120625814422965, 0.006594184320420027, -0.01677868142724037, 0.006996731739491224, -0.015521202236413956, 0.028069686144590378, -0.04057229310274124, -0.007990110665559769, 0.01321187149733305, -0.02966451644897461, -0.008515799418091774, -0.019889749586582184, -0.0008202949538826942, -0.01526414044201374, -0.024207666516304016, 0.014100873842835426, 0.019180970266461372, 0.04223614186048508, 0.002535904524847865, 0.012751985341310501, -0.043319426476955414, 0.005824436899274588, 0.0037820707075297832, -0.003750031813979149, 0.011751805432140827, 0.007566114421933889, 0.006316680461168289, 0.03377796337008476, 0.006784219294786453, 0.02561097964644432, -0.02007702924311161, -0.0061856950633227825, -0.002765678334981203, 0.016005128622055054, 0.01711944118142128, 0.01691433973610401, 0.013758735731244087, -0.005279060918837786, 0.002640985883772373, -0.0041938479989767075, 0.020095814019441605, -0.0012699600774794817, -0.003934267442673445, -0.0002294208388775587, 0.02965341880917549, 0.030871398746967316, -0.019548460841178894, -0.02029784768819809, -0.012612324208021164, -0.001932789571583271, -0.014458047226071358, -0.011570396833121777, 0.01609848067164421, -0.010576567612588406, 0.00003995816223323345, 0.004555094055831432, -0.030192233622074127, -0.0009677279740571976, 0.00405558105558157, -0.011042189784348011, -0.003429570235311985, 0.010043266229331493, 0.012930558994412422, -0.009098721668124199, 0.019573574885725975, -0.0026541389524936676, -0.027936594560742378, -0.009707584977149963, -0.012040696106851101, 0.0004817768931388855, 0.006136709358543158, 0.017099592834711075, -0.02768825553357601, 0.005057916976511478, -0.008001856505870819, -0.0028875861316919327, -0.025853333994746208, -0.03460244834423065, 0.004729910753667355, 0.033419184386730194, 0.020559996366500854, -0.01962103322148323, 0.013038810342550278, 0.015919163823127747, -0.0022063651122152805, 0.008182273246347904, -0.01853460632264614, -0.005705700255930424, 0.004356650169938803, 0.012878608889877796, 0.01197358500212431, 0.010212399065494537, -0.02500866912305355, 0.01471898052841425, -0.022042490541934967, -0.01615900546312332, -0.031721081584692, 0.019409021362662315, 0.011884229257702827, -0.011517737992107868, 0.007733609527349472, -0.0020909197628498077, -0.019231289625167847, -0.012805856764316559, -0.0043368213810026646, 0.0441034771502018, 0.0197613388299942, 0.04438791796565056, 0.0030824874993413687, -0.02877165749669075, 0.07102547585964203, -0.013362597674131393, -0.017905468121170998, 0.0025812783278524876, 0.03710761293768883, -0.017654795199632645, -0.0294114388525486, 0.00934121198952198, 0.019343148916959763, 0.0030725346878170967, 0.015856776386499405, -0.01661350019276142, 0.005304464139044285, 0.02771073766052723, -0.022582340985536575, 0.012180568650364876, 0.003410870209336281, -0.0024168835952878, 0.026545414701104164, -0.01506139151751995, 0.01879778876900673, 0.0003611312713474035, -0.009663289412856102, -0.029809121042490005, -0.00001498498022556305, 0.013232325203716755, 0.008869173936545849, -0.012340612709522247, -0.02770763821899891, 0.006922814529389143, 0.015131906606256962, -0.02222514897584915, -0.007514086551964283, 0.009602377191185951, 0.03982505202293396, -0.025200454518198967, 0.025354981422424316, -0.01166548766195774, -0.014743881300091743, 0.004720152355730534, 0.014515867456793785, -0.010154148563742638, 0.04210830479860306, 0.01018211618065834, 0.012468545697629452, -0.01809774711728096, 0.008569593541324139, -0.006462784484028816, -0.016143567860126495, -0.025381645187735558, -0.027470139786601067, 0.0008658936712890863, 0.022225994616746902, 0.04394526034593582, -0.022778257727622986, 0.0022799503058195114, 0.0063545843586325645, -0.00492453295737505, 0.0025097187608480453, -0.00500970333814621, -0.03325490653514862, 0.030836503952741623, -0.0010351515375077724, -0.011146730743348598, -0.015602689236402512, -0.004483691416680813, -0.006922834552824497, -0.004316562321037054, -0.008669404312968254, -0.01692184992134571, -0.006646734196692705, -0.018838683143258095, -0.0299376193434, -0.005296684801578522, -0.009113527834415436, -0.042056046426296234, -0.0030774776823818684, -0.004623478278517723, 0.0006662150844931602, -0.012277618050575256, 0.007298908196389675, 0.0035933246836066246, -0.0008218474686145782, -0.00021242117509245872, -0.023474257439374924, 0.0059196557849645615, -0.027649765834212303, -0.07445410639047623, 0.01537103857845068, -0.022894319146871567, -0.012966068461537361, -0.017036356031894684, -0.01792149618268013, -0.022469792515039444, 0.017542656511068344, 0.006965848617255688, 0.00067193026188761, 0.014992525801062584, 0.002228992525488138, -0.004682839382439852, -0.01075713150203228, 0.01423999760299921, 0.023050282150506973, -0.027201207354664803, -0.0019645835272967815, -0.04406353086233139, -0.02065994217991829, -0.003983546048402786, -0.0016803345642983913, -0.021708600223064423, 0.006126687861979008, 0.0021257020998746157, -0.08007340133190155, 0.015542253851890564, -0.021758006885647774, -0.02307773567736149, -0.0025017797015607357, -0.00669310986995697, 0.019812218844890594, -0.0037905711214989424, -0.01227616611868143, -0.01978956162929535, 0.028533365577459335, 0.03273569419980049, -0.026819970458745956, 0.004666976630687714, 0.005820118822157383, -0.0017149330815300345, 0.017491770908236504, -0.0025212750770151615, -0.026191934943199158, -0.013631995767354965, 0.012813907116651535, 0.008852395229041576, -0.013174754567444324, -0.003214220516383648, -0.01057384442538023, -0.012502382509410381, 0.0016789347864687443, 0.01721308007836342, 0.00004407856613397598, 0.013738375157117844, -0.01785639300942421, 0.004957434721291065, -0.012134408578276634, -0.015234468504786491, -0.0030881797429174185, -0.015823468565940857, 0.0005929013714194298, 0.008789384737610817, 0.005370794795453548, -0.016105080023407936, -0.0036630923859775066, -0.00447993166744709, -0.02701631560921669, 0.006633529905229807, -0.004435282200574875, 0.019933223724365234, 0.004305317532271147, -0.005421118810772896, 0.009950374253094196, -0.015590652823448181, 0.011230593547224998, -0.008826257660984993, -0.018898922950029373, -0.002949298359453678, -0.022559121251106262, 0.02077854797244072, -0.006840026006102562, 0.021824099123477936, 0.010794167406857014, -0.0023744020145386457, -0.001742874039337039, 0.004475817084312439, 0.010123473592102528, 0.07058824598789215, -0.0180306825786829, 0.028451308608055115, 0.00854868721216917, -0.0034372638911008835, 0.0030201429035514593, 0.0031506894156336784, 0.002473213244229555, 0.011819325387477875, -0.023781411349773407, 0.04806220531463623, -0.01800679601728916, -0.009577465243637562, 0.012672461569309235, -0.007297080475836992, 0.022698797285556793, 0.019162122160196304, 0.013374481350183487, 0.011084724217653275, 0.003202676773071289, 0.005523462779819965, -0.005051556043326855, -0.010529427789151669, -0.014846774749457836, -0.003902854397892952, 0.002832716330885887, 0.0042451368644833565, -0.00932352989912033, -0.0010675188386812806, 0.017842307686805725, 0.005168981850147247, 0.015354379080235958, -0.003972875420004129, -0.008457766845822334, 0.014629293233156204, 0.03268764168024063, 0.0027781000826507807, 0.005632232874631882, -0.013676298782229424, -0.005232657305896282, -0.008750524371862411, 0.0021792647894471884, 0.002584849949926138, 0.006514722481369972, -0.019271589815616608, 0.011002713814377785, -0.0034738946706056595, -0.00536328973248601, -0.01173908356577158, 0.006733858957886696, 0.014603298157453537, -0.0002975326497107744, -0.0022312395740300417, -0.005422988906502724, 0.012479742057621479, -0.01282578520476818, -0.011641212739050388, 0.01649857871234417, -0.0078359954059124, -0.013902000151574612, -0.0062650940380990505, -0.029142852872610092, -0.02769843488931656, -0.015848733484745026, 0.029454290866851807, -0.001076914370059967, 0.03288354352116585, -0.024433432146906853, -0.018575415015220642, 0.02228904888033867, -0.025534290820360184, -0.025158904492855072, 0.007996639236807823, 0.011986327357590199, 0.020579755306243896, 0.006905796937644482, -0.0030092434026300907, -0.010880655609071255, 0.013237785547971725, 0.01935841143131256, -0.014111405238509178, 0.021011127158999443, -0.014745695516467094, 0.04519776254892349, 0.00407507736235857, -0.027662958949804306, 0.008321715518832207, -0.0012716557830572128, -0.006584743037819862, 0.0157375019043684, 0.019547592848539352, -0.0167904794216156, -0.0035497292410582304, 0.020131953060626984, 0.01301425788551569, 0.03633805364370346, 0.012361698783934116, -0.0010678201215341687, 0.0030566276982426643, 0.005816995166242123, 0.030843030661344528, -0.008194247260689735, -0.014943014830350876, 0.024466704577207565, 0.003453432582318783, -0.0007019334007054567, 0.011850232258439064, -0.0025463912170380354, -0.009953171014785767, 0.05941542983055115, -0.009902378544211388, 0.009154362604022026, 0.019948462024331093, 0.0215938501060009, 0.009281156584620476, 0.013123000040650368, -0.007845189422369003, -0.0026240553706884384, -0.017254039645195007, -0.011876453645527363, -0.003083054907619953, -0.0043990942649543285, -0.01774061843752861, 0.004002105910331011, -0.025661807507276535, -0.005685862153768539, -0.01880228891968727, 0.02630866877734661, 0.006677488796412945, -0.017220472916960716, 0.01594197005033493, -0.013095677830278873, 0.006905936636030674, 0.01343729067593813, -0.0024268103297799826, 0.01837235875427723, -0.018627440556883812, 0.011959588155150414, 0.006679250858724117, 0.004829224199056625, 0.004763299133628607, -0.028074927628040314, -0.00789707712829113, 0.007971443235874176, 0.010284816846251488, 0.01676727831363678, 0.01728850230574608, 0.006515394896268845, 0.009019473567605019, 0.002042727777734399, -0.0019960873760282993, 0.00496347900480032, 0.019124124199151993, -0.010922737419605255, 0.018482523038983345, 0.01783685013651848, 0.006794781889766455, -0.0013142046518623829, -0.026487870141863823, -0.010619264096021652, 0.006205415353178978, -0.00799257680773735, 0.01626337505877018, 0.015031255781650543, 0.01312679797410965, 0.016237949952483177, -0.012256610207259655, 0.017325684428215027, -0.024254709482192993, -0.015567936934530735, 0.022637635469436646, 0.016931692138314247, -0.02690642513334751, 0.0062041920609772205, -0.015289698727428913, -0.007682329043745995, 0.009525538422167301, 0.006062143947929144, 0.011562984436750412, 0.0020057158544659615, -0.002130058128386736, -0.032635778188705444, 0.004981206730008125, -0.006680741906166077, 0.004598485305905342, 0.0206005796790123, -0.016473984345793724, -0.022014353424310684, 0.007198166102170944, -0.0019890086259692907, 0.0021338178776204586, 0.0011594959069043398, -0.01377904787659645, 0.0035319668240845203, -0.02010674588382244, -0.0063158078119158745, 0.013591721653938293, -0.029424797743558884, 0.0004344183253124356, 0.010272165760397911, -0.0014060973189771175, -0.01540092471987009 ]
[ -0.35854223370552063, 0.37503111362457275, 0.4176025092601776, -0.1722731739282608, -0.13220594823360443, -0.3375073969364166, 0.07153687626123428, -0.412650465965271, 0.1717056930065155, -0.4708574116230011, 0.18588851392269135, 0.6409713625907898, -0.326371431350708, 0.20700402557849884, 0.02860415168106556, 0.4233173131942749, 0.44222205877304077, 0.23774796724319458, -0.2788015305995941, -0.8760766983032227, -0.16406069695949554, -0.24530993402004242, 0.6933981776237488, 0.021362589672207832, 0.21415168046951294, -0.06874815374612808, 0.4096057713031769, 0.05540560930967331, 0.46617579460144043, -0.2962830364704132, 0.32380056381225586, 0.3966273367404938, -0.5730051398277283, 0.004389698151499033, -0.06058356910943985, -0.03759932890534401, -0.21733053028583527, 0.13627901673316956, -0.2323015332221985, -0.3487454950809479, -0.05162213370203972, -0.3992449641227722, -0.21583139896392822, 0.5599779486656189, -0.20037786662578583, -0.28215909004211426, -1.0796566009521484, 0.742530345916748, -0.20144709944725037, 0.03414015844464302, 0.2966979742050171, 0.30797672271728516, 0.6054338812828064, 0.4363553524017334, 0.15453939139842987, -0.2041073441505432, -0.5564610362052917, -0.23541568219661713, 0.51249098777771, -0.7399922013282776, -0.30525508522987366, 0.40784189105033875, -0.4821081757545471, -0.14082233607769012, -0.019406098872423172, 0.563500165939331, 0.21829897165298462, -0.7007983922958374, -0.31642645597457886, -0.1818826049566269, 0.09835714101791382, -0.5773656368255615, 0.3009583353996277, 0.4696308970451355, -0.0857732817530632, -0.16717049479484558, -0.29757729172706604, -0.5987290143966675, 0.15644429624080658, -0.18016423285007477, 0.22996485233306885, 0.023158784955739975, 0.24821648001670837, 0.04904070124030113, 0.5842494964599609, 0.07970505207777023, -0.43970972299575806, 0.7727745175361633, -0.9620686769485474, 0.405863881111145, -0.09513979405164719, -0.06535445898771286, 0.2136571705341339, 0.17591524124145508, 0.4799156188964844, 0.5739825367927551, 0.4719218611717224, 0.035544611513614655, 0.19016461074352264, 0.2440797984600067, 0.023076459765434265, 0.09417988359928131, -0.019107380881905556, -0.4016980230808258, -0.44083070755004883, -0.3941861391067505, -0.32612448930740356, -0.27226901054382324, -0.7420367002487183, 0.21938975155353546, -1.0765902996063232, -0.2542228400707245, -0.20771761238574982, -0.30291101336479187, 0.04185091331601143, -0.1784365028142929, -0.07997207343578339, -0.17974719405174255, 0.03497904911637306, 0.39878812432289124, 0.12729933857917786, 1.3347322940826416, -0.4080716073513031, 0.5178890824317932, -0.036223139613866806, -0.002593819983303547, 0.1891709268093109, 0.1702721267938614, -0.6834639310836792, 0.6184871196746826, -0.48274898529052734, 1.0333551168441772, -0.11570186913013458, 0.29300040006637573, 0.09805947542190552, -0.18060211837291718, 0.3149418234825134, 0.06016720458865166, 0.30439379811286926, 0.27502843737602234, -0.3499795198440552, -0.6139897108078003, -0.14259430766105652, 0.3425545394420624, 0.1782173365354538, -0.5685029625892639, 0.09863178431987762, -0.24861201643943787, 0.23651449382305145, -0.37082651257514954, -0.27154314517974854, 0.18812279403209686, -0.4670442044734955, 0.0320536270737648, -0.04452253878116608, 0.7398180365562439, 0.4857606589794159, -0.06817582249641418, 0.02135442942380905, 0.3502677381038666, -0.3078743517398834, -0.07583639770746231, -0.7606463432312012, 0.01972024329006672, 0.3864227533340454, -0.13906319439411163, 0.1910301148891449, 0.5592024326324463, 0.2437845766544342, -0.05962948501110077, -0.05893903225660324, -0.4338293671607971, -0.3501419425010681, -0.51156085729599, -0.36247873306274414, 0.028465142473578453, 0.6221789717674255, 0.04044664278626442, -0.12665589153766632, 0.22923006117343903, -0.7515224814414978, 0.3144303560256958, -0.04020940512418747, -0.5452636480331421, 0.8052820563316345, 0.4623097777366638, 0.30534982681274414, -0.32037124037742615, -0.2772301435470581, -0.07371694594621658, 0.31364309787750244, -0.19327358901500702, 0.6177474856376648, -0.8873911499977112, 1.613052248954773, 0.1379891335964203, 0.06242843344807625, 1.2751855850219727, 0.100578673183918, -0.19720149040222168, 0.124411441385746, 0.31476110219955444, 0.27512747049331665, -0.22682558000087738, -0.30730798840522766, 0.09726803749799728, 0.17415672540664673, -0.3039354383945465, 0.04013713449239731, -0.2527729570865631, 0.4915287494659424, -0.13261282444000244, 0.10225817561149597, -0.20047606527805328, 0.34767693281173706, -0.6779386401176453, -0.08727232366800308, 0.42264899611473083, -0.5593267679214478, 0.04148309305310249, 0.7079516649246216, -0.7768557667732239, 0.6985582113265991, 1.2210134267807007, -0.2299579530954361, 0.6555339097976685, 0.29451116919517517, 0.1551700085401535, 0.625740647315979, 0.003703674068674445, 0.14289940893650055, -0.22096846997737885, 0.25603970885276794, -0.5124709606170654, 0.066556416451931, 0.14333823323249817, 0.4308996796607971, -0.4871326982975006, -0.08598122000694275, 0.030461471527814865, -0.2701404094696045, 0.46474286913871765, -0.40439510345458984, 0.20336446166038513, 0.05328252911567688, -0.5568011403083801, -0.12484721839427948, -0.11011653393507004, -0.7916683554649353, 0.39092540740966797, -0.1106739267706871, 0.02200106717646122, 0.22924086451530457, -0.3939138650894165, 0.5650405883789062, -0.11399445682764053, -0.2674524486064911, -0.4174688458442688, -0.319695383310318, -0.42891520261764526, 0.15081185102462769, -0.2161855399608612, 0.04333538934588432, 0.08261933922767639, -0.6444734334945679, -0.2881089448928833, -0.14669671654701233, -0.3433140218257904, 0.8873382210731506, 0.6901046633720398, 0.6348220705986023, 0.10805930942296982, -0.4729496240615845, 0.14786610007286072, -0.26881375908851624, -0.43679916858673096, -0.3682817220687866, 0.40201663970947266, -0.24232637882232666, -0.2917516231536865, 0.09150919318199158, 0.5629016160964966, 0.7403967380523682, -0.32151567935943604, -0.42572081089019775, -0.014807428233325481, 0.03964561969041824, -0.517562210559845, -0.4770611524581909, -0.06164494529366493, 0.08016299456357956, -0.13334053754806519, -0.05292244255542755, -0.3527218997478485, 0.20274196565151215, 0.700676441192627, 0.383097380399704, 0.44709667563438416, 0.19830945134162903, -0.03482922539114952, -0.3803336024284363, 0.07487263530492783, -0.2519805431365967, -0.06751607358455658, -0.18237803876399994, -0.2681882977485657, -0.5710586905479431, 0.2739180028438568, -5.7282819747924805, 0.01043677981942892, 0.2944857180118561, 0.11231357604265213, -0.16183757781982422, 0.026055121794342995, 0.9629461765289307, -0.1798381805419922, -0.004902134649455547, 0.1661335527896881, 0.07064763456583023, 0.699275016784668, 0.12088050693273544, 0.01193435862660408, -0.0057944124564528465, -0.13786627352237701, -0.31190720200538635, -0.3263378143310547, 0.648566722869873, -0.02398478053510189, 0.5507287383079529, -0.6353103518486023, 0.044743530452251434, 0.2352273315191269, -0.07024147361516953, 0.23567436635494232, -0.7044514417648315, -0.17186039686203003, 0.085967518389225, -0.15287314355373383, 0.12394753098487854, -0.27492713928222656, -0.005927413702011108, -0.22664839029312134, 0.4615371823310852, 0.1604643315076828, 0.06746897846460342, 0.23852024972438812, 0.24237346649169922, -0.8118833303451538, 0.6138080358505249, 0.588495135307312, -0.2510804235935211, 0.1721847951412201, 0.021687591448426247, -0.44116708636283875, -0.009951206855475903, 0.7383644580841064, -0.6518142223358154, 1.2234809398651123, -0.19949668645858765, 0.01719697006046772, 0.618517279624939, 0.5226365327835083, 0.5971899032592773, -0.1628880649805069, -0.09851230680942535, -0.35351207852363586, -0.6177117228507996, 0.08335401117801666, -0.6486731767654419, -0.3972475230693817, -0.3456003963947296, -0.924579381942749, -0.09555590897798538, 0.3351862132549286, -1.0248943567276, -0.5834210515022278, 0.23843207955360413, -0.24267075955867767, -0.21651095151901245, 0.2777846157550812, 0.0639507994055748, -0.4794074594974518, 0.6910786032676697, -0.40844565629959106, 0.4996262490749359, -0.0013518817722797394, 0.1717885285615921, -0.0629952996969223, -0.3152061998844147, -0.008997826837003231, -0.1963791698217392, -0.13846969604492188, -0.04802814498543739, -0.325827419757843, -0.09517577290534973, -0.13380461931228638, -0.3843114674091339, -0.05624052509665489, 0.5303459167480469, 0.03642294555902481, 0.14331591129302979, 0.6731967926025391, 0.405892014503479, 0.15993140637874603, 0.21081401407718658, 0.4730677008628845, 0.7962546348571777, 0.003909204620867968, 0.8390704393386841, 0.07721218466758728, -0.1149076521396637, -0.7402606010437012, 0.03920154646039009, 0.26874589920043945, -0.6500676274299622, 0.18239331245422363, 0.5840864777565002, -0.5623311400413513, -0.12818051874637604, -0.3610607087612152, -0.5858131051063538, -0.4600508511066437, 0.39707082509994507, -0.1115817278623581, -0.5776995420455933, 0.14383110404014587, 0.5754355788230896, -0.20816554129123688, 0.3879793882369995, 0.13275177776813507, -0.04243898764252663, 0.2951396405696869, 0.3456646800041199, -0.01974470540881157, 0.04231683164834976, 0.7916797995567322, -0.7585089206695557, -0.46543893218040466, 0.3013620376586914, 0.39021745324134827, -0.45170146226882935, 0.10725639760494232, 0.036535460501909256, -0.3790212869644165, -0.5268808007240295, 0.20815426111221313, 0.2869008183479309, -0.18217721581459045, 0.5303465723991394, -0.4568631649017334, -0.5386058688163757, -0.18654587864875793, -0.09679422527551651, 0.016735270619392395, -0.5937995314598083, 0.0702323317527771, -0.11524944007396698, 0.05045342817902565, -0.270424485206604, -0.18248608708381653, 0.1554291844367981, -0.1221337765455246, 0.005215660203248262, 0.3321226239204407, 0.5610076189041138, 0.304322749376297, 0.3578987121582031, -0.40548714995384216, -0.09466265141963959, 0.5064186453819275, -0.6265811920166016, 0.2868938446044922, -0.2815067768096924, -0.3045794367790222, -0.6173422336578369, -0.35689979791641235, -0.31026363372802734, 0.09739432483911514, -0.2296728491783142, -0.1621256321668625, -0.07228837162256241, -0.5755187273025513, -0.1339101791381836, 0.007658138871192932, -0.34901896119117737, 0.5036057233810425, 0.1413552314043045, -0.42866209149360657, 0.3727734088897705, -0.6923174262046814, 0.1261267215013504, 0.037104297429323196, 0.682125985622406, -0.22360187768936157, 0.2526206970214844, -0.18814711272716522, 0.034304626286029816, -0.2592591643333435, 0.40537092089653015, 0.32393428683280945, 0.3276319205760956, -0.43379101157188416, 0.20864370465278625, -0.005788379814475775, 0.19744816422462463, -0.08898884803056717, -0.14904266595840454, -0.8704655170440674, 0.2573525607585907, 0.3274247348308563, -0.8950746655464172, 0.6070421934127808, -0.026837317273020744, 0.0539516806602478, 0.4427652060985565, 0.08956481516361237, -0.06984554976224899, -0.33884263038635254, -0.39681828022003174, -0.36048343777656555, 0.3261636793613434, 0.44697362184524536, -0.40835145115852356, 0.08753707259893417, 0.1513097584247589, -0.22864387929439545, -0.35298386216163635, 0.432267963886261, 0.20031976699829102, -0.4324765205383301, -0.18947036564350128, 0.0969850942492485, -0.5414461493492126, 0.02212393656373024, 0.3326098918914795, -0.589443027973175, 0.09443305432796478, -0.05951841175556183, -0.5839069485664368, -0.2681758999824524, -0.1727980524301529, -0.14293545484542847, -0.2095801830291748, -0.2528028190135956, -0.5744457840919495, -0.058729588985443115, -0.28665024042129517, 0.2622320055961609, 0.5057104825973511, 0.8235203623771667, -0.6255248785018921, -0.16965113580226898, 0.007105263415724039, 0.6923935413360596, 0.5182138085365295, -0.6360909938812256, -0.3383469581604004, -0.4292064607143402, 0.4586743116378784, -0.28414928913116455, -0.17096930742263794, 0.4378218948841095, 0.93988037109375, 0.30491387844085693, -0.36970749497413635, -0.17052093148231506, -0.07922293990850449, 0.1255636215209961, -0.5580224394798279, -0.515519917011261, -0.3464747667312622, -0.3553825616836548, 0.30225223302841187, -0.121076799929142, 0.20869864523410797, -0.7969797849655151, 0.1995014250278473, -0.16580581665039062, 0.12405981123447418, -0.05017688125371933, 1.0144708156585693, -0.2525022029876709, -0.29957443475723267, 0.11038187146186829, -0.36578893661499023, 0.26602262258529663, 0.16498775780200958, 0.09104810655117035, -0.3334193825721741, -0.6306366920471191, 0.0255886260420084, -0.4904851019382477, 0.41129690408706665, -0.6547896265983582, 0.3488526940345764, -0.368805468082428, 0.10762906074523926, -0.5086199045181274, -0.12281518429517746, -0.04978925734758377, -0.37800949811935425, -0.5095933675765991, 0.19950233399868011, 0.25876206159591675, -0.07572747766971588, 0.25083717703819275, -0.03136870637536049, 0.03510444611310959, -0.8441179990768433, 0.8816545605659485, 0.2458348423242569, -0.7414947152137756, 0.19935043156147003, 0.5221544504165649, 0.1767832338809967, -0.2617093324661255, -0.3397144675254822, -0.2528385519981384, -0.2418888360261917, -0.327511727809906, 0.031550850719213486, 0.2648003399372101, -0.284298837184906, 0.006095901131629944, 0.11657366156578064, -0.2910362780094147, 0.42205747961997986, 0.28165650367736816, -0.06796044111251831, 0.6419678926467896, 0.6807509660720825, -0.12471037358045578, -0.01543299201875925, 0.4559566378593445, -0.13042029738426208, 0.06967319548130035, -0.01876003108918667, 0.6455928683280945, 0.9808694124221802, 0.5848967432975769, -0.050016503781080246, 0.25827112793922424, 0.4985121488571167, 0.01823711208999157, 0.1753970980644226, -0.24135515093803406, -0.5859555006027222, 0.4730357527732849, -0.05489877983927727, 0.3124127984046936, -0.554750382900238, 0.11285606771707535, 0.26827672123908997, 0.22183191776275635, 0.44947338104248047, 0.25324901938438416, -0.4679074287414551, 0.3897590935230255, 0.26561468839645386, -0.3212660849094391, -0.21761348843574524, 0.26363474130630493, -0.8695257902145386, 0.0189475417137146, 0.7352721095085144, -0.19901610910892487, 0.005317045841366053, 0.21179623901844025, -0.5622081756591797, 0.33347171545028687, -0.3400079607963562, 0.4907390773296356, -0.14929024875164032, 0.21895869076251984, 0.687724232673645, 0.05130813270807266, 0.5931947827339172, -0.05250722914934158, 0.1025037169456482, 0.534436821937561, -0.4654923975467682, 0.5079245567321777, -0.3293437063694, -0.7763801217079163, -0.05953740328550339, 0.10058039426803589, -0.03763644024729729, 0.015090465545654297, -0.17031623423099518, 0.4278019368648529, 0.04339076951146126, -0.7379717230796814, -0.22235973179340363, -0.6615701913833618, -0.09366413950920105, 0.26871782541275024, 0.37192264199256897, -0.11514213681221008, 0.44316205382347107, -0.5329477787017822, 0.4409851133823395, -0.011923612095415592, 0.3526964485645294, 0.2468762844800949, -0.31997185945510864, 0.5494938492774963, 0.48614269495010376, 0.3555828034877777, -0.060622088611125946, 0.8310981392860413, -0.03313183784484863, 0.3554009199142456, -0.6528559923171997, 0.5905466675758362, -0.4490741789340973, -0.24588745832443237, -0.7937299609184265, -0.31658878922462463, 0.9028896689414978, 0.5689066052436829, -0.23359264433383942, -0.015512383542954922, 0.2069101184606552, 0.42661216855049133, 0.4100324809551239, -0.5994402170181274, -0.05216003209352493, -0.5783122777938843, -0.22814175486564636, -0.3097672164440155, 0.5965126752853394, -0.13034136593341827, -0.09967982023954391, -0.28749310970306396, 0.6106639504432678, 0.03783119469881058, 0.06154529005289078, 0.5736465454101562, 0.14368519186973572, 0.19291093945503235, -0.8921394348144531, 0.4992764890193939, -0.3810766041278839, 0.17366644740104675, -0.8104826807975769, -0.07162906974554062, 0.3713018298149109, -0.34207379817962646, 0.12127524614334106, 0.07427381724119186, -0.22430434823036194, 0.36364516615867615, -0.013110886327922344, -0.04423017427325249, -0.39496105909347534, -0.7284841537475586, -0.26770198345184326, 0.27018997073173523, 0.5446864366531372, -0.7634485960006714, 0.28150609135627747, -0.27182698249816895, -0.12353944778442383, 0.09634117037057877, -0.2707064747810364, -0.4955865442752838, -0.20529958605766296, 0.3722389340400696 ]
Aberrant overexpression of the long non-coding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) has been documented in different types of solid tumours, such as lung cancer, oesophageal cancer, colorectal cancer and hepatocellular carcinoma, in which its high levels are associated with poor prognosis. In contrast, NEAT1 is downregulated in acute promyelocytic leukaemia where it promotes leucocyte differentiation. In this review, we provide an overview of current evidence concerning the oncogenic role and potential clinical utilities of NEAT1. Further investigations are warranted to elucidate the upstream and downstream mechanisms of NEAT1 overexpression.
[ -0.0003495419514365494, 0.007647783495485783, -0.008137069642543793, 0.01002153567969799, 0.001681990921497345, 0.0007710661739110947, 0.00966125912964344, 0.026709821075201035, -0.00724004628136754, 0.02870737947523594, -0.008758528158068657, 0.0023382618092000484, 0.002870748518034816, 0.0013162122340872884, -0.02628752775490284, -0.00599063141271472, -0.01810576394200325, 0.004572282545268536, 0.010502506047487259, 0.00035345624200999737, -0.025412509217858315, 0.00020734639838337898, 0.00901217944920063, 0.013992346823215485, 0.014301883056759834, 0.02319028601050377, -0.007237135898321867, -0.001215087715536356, -0.008447382599115372, -0.003053491236642003, -0.011765722185373306, -0.003383287228643894, 0.02068856917321682, -0.0054809655994176865, -0.013076521456241608, -0.013432465493679047, -0.009003201499581337, 0.01216977834701538, 0.0038639362901449203, -0.007075242232531309, 0.01421564631164074, -0.014554686844348907, 0.0011278553865849972, -0.01808452233672142, -0.007400554604828358, 0.011797651648521423, -0.0013632472837343812, -0.00670674629509449, -0.0017108690226450562, 0.007295995019376278, -0.009128537960350513, 0.025296151638031006, -0.01829313300549984, 0.001577629940584302, -0.005560531280934811, 0.009556448087096214, 0.015400498174130917, 0.015705343335866928, 0.010280812159180641, 0.0032478892244398594, 0.021733980625867844, 0.005593720357865095, 0.0037957304157316685, 0.029567763209342957, 0.00947955809533596, -0.0670422837138176, 0.035425469279289246, -0.018155459314584732, -0.008895404636859894, -0.01371956430375576, -0.03038247674703598, 0.004748827312141657, -0.010148733854293823, -0.016942482441663742, 0.023118309676647186, -0.005463288631290197, -0.008272211067378521, 0.00985285546630621, 0.0034642559476196766, 0.019483420997858047, -0.0181336160749197, 0.001536110183224082, -0.0281069353222847, 0.024252330884337425, -0.00018196925520896912, -0.001146316877566278, -0.020089739933609962, -0.0011973927030339837, 0.028358101844787598, -0.009572893381118774, 0.015962427482008934, 0.00021872366778552532, -0.03271793946623802, 0.0029330342076718807, -0.018517274409532547, 0.0036265417002141476, 0.009869994595646858, 0.008697823621332645, 0.03574205935001373, 0.023305818438529968, -0.009870861656963825, 0.008658609353005886, 0.01984712854027748, -0.009882310405373573, -0.0057121445424854755, 0.006441021338105202, -0.021530218422412872, -0.016330279409885406, 0.014355204999446869, 0.00873560644686222, 0.006626318208873272, -0.004160385113209486, 0.00332539901137352, 0.019782254472374916, -0.009208690375089645, -0.011891650035977364, 0.016875214874744415, -0.004479742608964443, 0.002292279154062271, -0.03072424978017807, -0.00861563440412283, 0.0084200045093894, -0.0062320176512002945, 0.031369589269161224, 0.007667809724807739, -0.012569780461490154, 0.011281551793217659, 0.014393714256584644, 0.01214586105197668, 0.007495760452002287, -0.008334686048328876, -0.0033308793790638447, 0.0020864736288785934, -0.012247011065483093, 0.0063217985443770885, 0.005473475903272629, 0.014628728851675987, -0.00980486162006855, -0.0009946044301614165, -0.01606091856956482, 0.018482277169823647, 0.009258072823286057, 0.005970965139567852, 0.011057405732572079, 0.005634275730699301, 0.010313283652067184, 0.03412312641739845, 0.001458246842958033, 0.010801732540130615, -0.010172809474170208, 0.008880514651536942, -0.015651756897568703, 0.0036595547571778297, -0.019479887560009956, 0.030040640383958817, 0.010576961562037468, -0.02473834902048111, 0.02059900015592575, -0.005582112818956375, 0.0212667528539896, -0.029358115047216415, -0.030403226613998413, -0.0015971268294379115, 0.008103873580694199, 0.015861012041568756, 0.0037102587521076202, -0.0023267290089279413, -0.015230903401970863, 0.008488195948302746, 0.009521483443677425, -0.0003855965915136039, -0.01861916482448578, -0.016890961676836014, 0.011830214411020279, -0.0019312433432787657, -0.00764241348952055, -0.006069428287446499, 0.007340253330767155, -0.02489510178565979, 0.06651611626148224, 0.02398661896586418, 0.02381008118391037, 0.02448934130370617, -0.011130521073937416, 0.007070629857480526, -0.008298645727336407, 0.023686999455094337, 0.0043321275152266026, 0.005758003331720829, 0.0013240897096693516, 0.012691904790699482, 0.018285760655999184, -0.00014905270654708147, 0.007391365710645914, -0.033169448375701904, 0.0023058545775711536, -0.007143029011785984, 0.0025609633885324, 0.006557358894497156, 0.020223740488290787, 0.002460343996062875, -0.004477715119719505, 0.005393673665821552, -0.015117891132831573, -0.025769725441932678, 0.024061884731054306, 0.011253831908106804, -0.015559332445263863, 0.008335908874869347, 0.02639991231262684, 0.019730113446712494, -0.04285874962806702, -0.023657601326704025, -0.011235141195356846, 0.014341707341372967, 0.021060466766357422, -0.009022990241646767, -0.0007621862459927797, -0.0012885163305327296, -0.009105904027819633, -0.0014026905409991741, 0.003514853771775961, 0.019193409010767937, -0.01709459349513054, -0.010499800555408001, -0.016824996098876, -0.002319525694474578, 0.008436283096671104, 0.02487313561141491, -0.0024721536319702864, -0.0154831912368536, -0.006638661026954651, -0.010874969884753227, -0.0055644395761191845, 0.024740010499954224, 0.00372936949133873, 0.011287339963018894, -0.020679431036114693, 0.0018122104229405522, -0.005121788941323757, -0.0129727553576231, -0.009124127216637135, 0.010926304385066032, -0.012204844504594803, 0.016257930546998978, -0.015729814767837524, 0.03814292699098587, -0.0028403201140463352, 0.005468833260238171, -0.007287775166332722, 0.005407014861702919, 0.0004781438037753105, 0.017513606697320938, 0.007425619754940271, -0.016551336273550987, 0.010275128297507763, -0.0002787772100418806, 0.00008040852844715118, 0.024340329691767693, -0.008212887682020664, 0.005723616108298302, 0.010785468854010105, 0.04160532355308533, -0.007053965236991644, -0.0012108655646443367, 0.009349864907562733, -0.00036619557067751884, -0.00027742190286517143, -0.012724112719297409, 0.0037042000330984592, 0.00955432839691639, -0.010029766708612442, -0.00039482832653447986, -0.08139637857675552, -0.010289199650287628, 0.011924824677407742, 0.027085278183221817, 0.002521384973078966, -0.010411560535430908, 0.00701426574960351, 0.001803443767130375, -0.016916867345571518, -0.0017980244010686874, 0.014369738288223743, 0.009292160160839558, -0.00999096967279911, -0.023754844442009926, 0.030809622257947922, -0.012131886556744576, 0.01163000613451004, -0.0005996308755129576, -0.025462664663791656, -0.0013977901544421911, 0.011462713591754436, -0.002471072366461158, 0.010667521506547928, 0.002506916644051671, -0.01726902835071087, 0.0365024171769619, 0.0028266659937798977, 0.0037260507233440876, -0.012684141285717487, 0.0014250841923058033, -0.008818849921226501, -0.018344860523939133, -0.002341656247153878, 0.0005787531845271587, 0.00842059962451458, -0.0029418040066957474, -0.02586795575916767, -0.01607469655573368, -0.0012880568392574787, -0.008873800747096539, -0.00877756904810667, 0.0076119378209114075, -0.004972850438207388, -0.003062828676775098, 0.0009602837963029742, 0.009289841167628765, 0.025124697014689445, -0.004079492762684822, 0.019473906606435776, 0.017221670597791672, 0.007868225686252117, -0.0027149978559464216, 0.02006206475198269, 0.008947056718170643, -0.012302173301577568, 0.0054546622559428215, -0.010720757767558098, -0.0015973537229001522, -0.010267168283462524, -0.00978376716375351, 0.01682586595416069, -0.0015770061872899532, 0.02370503917336464, -0.01718318834900856, 0.01389363594353199, 0.0019049430266022682, 0.002300175139680505, -0.002625048393383622, -0.018708033487200737, 0.020662248134613037, -0.008651383221149445, -0.0006498126313090324, -0.014792153611779213, -0.009512478485703468, -0.012937958352267742, -0.006792666390538216, -0.010672320611774921, -0.013637259602546692, -0.015522681176662445, -0.02419660985469818, -0.017906708642840385, -0.00075926398858428, -0.013352508656680584, -0.008941642940044403, -0.006987704895436764, -0.0001239599660038948, 0.008082332089543343, 0.012605223804712296, 0.01175341010093689, -0.012136874720454216, 0.02527909353375435, 0.010132472962141037, -0.009541414678096771, 0.012003458105027676, -0.017467627301812172, -0.05133497714996338, 0.017690276727080345, -0.0127352774143219, 0.027723044157028198, 0.006801133044064045, -0.01736753061413765, 0.003446124028414488, 0.018119361251592636, -0.00897190161049366, -0.008176887407898903, 0.008509175851941109, 0.00911596417427063, 0.0036665573716163635, -0.01601547747850418, -0.004390072077512741, -0.017128922045230865, -0.01002819649875164, -0.004521504044532776, 0.001333146821707487, 0.008527283556759357, 0.00007419777102768421, 0.014159240759909153, -0.00827491283416748, 0.07229401171207428, 0.012149274349212646, 0.018319766968488693, -0.027482153847813606, 0.013051195070147514, 0.002919621765613556, -0.0284922756254673, -0.00040878879372030497, -0.04422330483794212, 0.005979073233902454, 0.011154057458043098, 0.001643930096179247, 0.007197104394435883, -0.011160587891936302, -0.0031758160330355167, 0.022292787209153175, 0.004305928014218807, 0.02231721021234989, 0.015236221253871918, 0.01931094378232956, -0.010994990356266499, -0.003796701319515705, -0.016493672505021095, -0.01482412125915289, -0.007176531478762627, -0.013947905041277409, 0.018688272684812546, -0.014642483554780483, -0.017575379461050034, 0.012786179780960083, -0.01750500500202179, -0.020714985206723213, -0.011132451705634594, -0.00683676777407527, 0.03006032109260559, 0.015486153773963451, 0.0051698582246899605, -0.014136310666799545, 0.0026355208829045296, 0.0009979275055229664, 0.0071478611789643764, -0.012536007910966873, -0.00867855828255415, 0.003959248773753643, -0.002851975616067648, 0.006409836933016777, 0.024423308670520782, -0.006783978082239628, 0.007207589223980904, 0.02450220100581646, -0.009740160778164864, -0.012360204942524433, 0.011314461007714272, 0.013517741113901138, -0.017492307350039482, -0.01389001403003931, 0.013350443914532661, -0.012640728615224361, -0.004486968275159597, -0.02590177021920681, 0.007469200994819403, -0.02617058902978897, -0.006713783368468285, 0.0034639392979443073, 0.014469325542449951, -0.018071291968226433, -0.012940095737576485, -0.015528337098658085, 0.004670332185924053, -0.005303073674440384, 0.014710451476275921, 0.037114210426807404, -0.0014930719044059515, -0.03004271537065506, -0.013354726135730743, 0.03157375752925873, 0.0030181831680238247, -0.008559875190258026, 0.003280193079262972, -0.007714353036135435, 0.009195651859045029, 0.010962980799376965, -0.003387216944247484, -0.0240813996642828, -0.00925888866186142, -0.009553061798214912, 0.018853221088647842, -0.07496896386146545, -0.022807013243436813, 0.014922190457582474, -0.0024200784973800182, 0.005349500570446253, 0.023584943264722824, -0.007907111197710037, -0.011523712426424026, -0.009568409994244576, 0.010819739662110806, 0.004440909251570702, -0.02035503089427948, 0.01383587159216404, -0.012332672253251076, 0.011703560128808022, 0.00828174315392971, 0.003923661075532436, 0.00040161050856113434, 0.002058669226244092, -0.010350463911890984, 0.013513674959540367, -0.0027309979777783155, -0.022437119856476784, -0.003271546447649598, -0.009786974638700485, -0.08117347955703735, -0.00347946397960186, -0.004853860475122929, 0.00831249263137579, -0.004848552402108908, -0.0034361244179308414, 0.011034296825528145, -0.025290129706263542, 0.010675349272787571, -0.012540021911263466, 0.007714258506894112, 0.016629880294203758, 0.025688663125038147, 0.0068194023333489895, 0.009533827193081379, -0.012706410139799118, 0.019247720018029213, -0.03696086257696152, 0.0015654033049941063, -0.023670244961977005, -0.023473745211958885, -0.0031570885330438614, -0.007320643402636051, 0.0011452599428594112, -0.007424164563417435, 0.006343116983771324, -0.02463255077600479, 0.008737636730074883, 0.0027829871978610754, -0.038205720484256744, 0.003832887625321746, -0.05368820205330849, -0.009088189341127872, 0.01778155378997326, -0.017066307365894318, -0.022944793105125427, -0.0012739086523652077, 0.008905240334570408, -0.0045842500403523445, 0.019796688109636307, -0.0065108779817819595, -0.001051497645676136, -0.012633102014660835, 0.020890554413199425, -0.01221485622227192, 0.0011046156287193298, 0.0065846992656588554, -0.020557308569550514, -0.006545579992234707, 0.02015620470046997, -0.001943575101904571, -0.017657019197940826, 0.030492085963487625, 0.006144451908767223, 0.022041425108909607, 0.018233589828014374, -0.000016199424862861633, -0.0019904300570487976, -0.004359602928161621, 0.018166594207286835, -0.008961731567978859, -0.0019544498063623905, -0.015874013304710388, 0.07185409963130951, -0.020576586946845055, 0.025058448314666748, -0.017456086352467537, 0.0008455077186226845, 0.008318042382597923, 0.010017598047852516, -0.01170065626502037, 0.0033111306838691235, -0.0009615403832867742, 0.01921961084008217, -0.010752955451607704, 0.01209886185824871, 0.012662328779697418, -0.000021602492779493332, 0.0246707983314991, 0.020269328728318214, -0.0005986390169709921, 0.008570016361773014, -0.0015645644161850214, 0.004424222279340029, 0.033950623124837875, 0.004402118735015392, -0.0011612838134169579, -0.00546278664842248, -0.02388276718556881, 0.007518457714468241, -0.0034719863906502724, -0.002619921462610364, -0.01008431427180767, 0.016956781968474388, 0.006588672287762165, 0.0025107278488576412, -0.025710329413414, 0.016817206516861916, 0.03420961648225784, -0.01673344522714615, 0.009964175522327423, -0.023196659982204437, -0.0060676042921841145, 0.026605477556586266, 0.011732107028365135, -0.00568095687776804, 0.012522419914603233, 0.023215174674987793, 0.009438274428248405, 0.0009692921303212643, -0.010533265769481659, 0.0021157758310437202, 0.0031996783800423145, 0.018049318343400955, 0.009463315829634666, 0.024458644911646843, -0.009485294111073017, 0.005562568083405495, 0.005739119835197926, 0.0007129753939807415, 0.010890664532780647, -0.018380461260676384, -0.01024033036082983, 0.031748753041028976, -0.00912212673574686, 0.00850969459861517, -0.006251298822462559, 0.013457436114549637, 0.011707291007041931, -0.005629085469990969, -0.029148701578378677, -0.0067929853685200214, 0.015296140685677528, 0.025023946538567543, -0.01599947176873684, 0.0112537182867527, 0.003232293063774705, 0.03446187078952789, 0.011083357967436314, 0.017305642366409302, -0.000888933427631855, 0.009802346117794514, -0.002136562718078494, -0.004645178094506264, -0.0006407955661416054, 0.0020863916724920273, 0.011047436855733395, -0.007927700877189636, 0.01552502904087305, 0.0077936383895576, -0.0038518854416906834, 0.003630588296800852, 0.006492800544947386, 0.005905679427087307, -0.0028864359483122826, 0.005694522522389889, 0.013592573814094067, 0.008228356949985027, 0.033590640872716904, -0.011022896505892277, 0.004610676318407059, 0.005663129035383463, -0.00864106323570013, -0.005175563506782055, 0.01054905541241169, -0.004983620718121529, -0.018193665891885757, -0.026120208203792572, -0.0021519735455513, -0.008842585608363152, -0.022684939205646515, -0.022343482822179794, 0.007762609981000423, 0.004866189789026976, -0.013636365532875061, 0.015297867357730865, 0.004179530777037144, 0.014620855450630188, 0.025222856551408768, -0.013114336878061295, -0.025670256465673447, -0.002334847580641508, -0.015572856180369854, -0.017854632809758186, -0.01185927540063858, -0.009175077080726624, 0.014206644147634506, -0.009645737707614899, -0.012059947475790977, -0.009875444695353508, -0.002654405077919364, -0.007326468825340271, -0.008020628243684769, 0.018528355285525322, 0.006323742214590311, -0.0012270936276763678, 0.011559506878256798, -0.01449329312890768, 0.02979375049471855, 0.015068604610860348, -0.010559146292507648, 0.0012378365499898791, 0.014701141975820065, -0.0026803123764693737, -0.008956247940659523, -0.007724479306489229, -0.00816703587770462, 0.007468889467418194, -0.006209474056959152, -0.0057433489710092545, 0.0023960310500115156, 0.011914844624698162, 0.005616115406155586, 0.011109016835689545, 0.00664657773450017, 0.006897450424730778, -0.008873513899743557, 0.0020600524730980396, 0.011165445670485497, 0.006678241305053234, -0.0017428596038371325, -0.012885021045804024, 0.0007251885253936052, 0.006717470474541187, 0.0017474107444286346, -0.005975974723696709, -0.019821930676698685, -0.013236288912594318, 0.02498294785618782, 0.01535697840154171, 0.010412786155939102, -0.004903505556285381, 0.01285647600889206, 0.020141420885920525, 0.0008521932177245617, 0.006521503906697035, 0.02149566076695919, -0.028138184919953346, -0.006461745593696833, -0.009505795314908028, -0.021413529291749, -0.0021269468124955893, 0.008597864769399166, -0.0031093766447156668, -0.013888152316212654, -0.0033224360086023808, -0.011183073744177818, -0.004709391389042139, -0.002584588946774602, 0.0013926118845120072, 0.0051704272627830505, -0.003575489390641451, 0.013954208232462406, -0.009732920676469803, -0.008517059497535229, -0.014278296381235123, -0.012145262211561203, -0.01549348421394825, 0.005396081134676933, 0.007674309425055981, -0.028515122830867767, 0.013800811022520065, -0.019258566200733185, 0.022795550525188446, -0.002714178990572691 ]
[ 0.07748240977525711, 0.2046736478805542, -0.34216538071632385, -0.2794119715690613, 0.004567359574139118, -0.0745396614074707, 0.425906240940094, 0.25966978073120117, 0.038364339619874954, -0.5508193969726562, 0.3056478500366211, 0.0036130433436483145, -0.4569161534309387, 0.2894570529460907, -0.8358834981918335, 0.6922382712364197, 0.5723314881324768, 0.3253858685493469, -0.006035882048308849, -0.40418848395347595, -0.17355455458164215, -0.1773398071527481, 0.04866247996687889, 0.11394201219081879, -0.24336014688014984, 0.08011826872825623, 0.37797844409942627, -0.6087855100631714, -0.059185221791267395, -0.3010980486869812, -0.3779272735118866, -0.19581261277198792, 0.6900526285171509, -0.03829086199402809, -0.3531343638896942, -0.09094557166099548, -0.4813787043094635, -0.3357508182525635, -0.026735154911875725, 0.41819989681243896, -0.15061961114406586, -0.5768454670906067, 0.2766592502593994, 0.3724457621574402, -0.3918038010597229, -0.23094457387924194, -1.164386510848999, 1.3460121154785156, -0.04252219572663307, -0.22564175724983215, 0.11883928626775742, 0.1180768832564354, 0.4965006709098816, 0.14353305101394653, 0.5066070556640625, -0.22030630707740784, -0.3573594391345978, -0.09193334728479385, 0.5934224724769592, -0.5616555213928223, -0.1495143473148346, 0.037536170333623886, -0.3981618285179138, 0.2106899619102478, 0.11269328743219376, 1.0412747859954834, -0.03516656160354614, 0.040651872754096985, -0.6925541162490845, -0.37813901901245117, 0.01855669915676117, -0.2639203667640686, -0.05930056422948837, -0.1598355919122696, -0.3168870508670807, -0.1451222151517868, -0.564489483833313, -0.3153561055660248, 0.22219543159008026, -0.24821029603481293, 0.2289234697818756, 0.0863766074180603, 0.3569122552871704, -0.21145784854888916, 0.2771541178226471, -0.041936878114938736, -0.16041319072246552, 0.8047237992286682, -0.5992139577865601, -0.2711853086948395, -0.0728556290268898, 0.1052432507276535, 0.650383472442627, 0.2711951732635498, -0.09823589771986008, 0.4443851411342621, -0.40530455112457275, 0.22833605110645294, 0.39251506328582764, 0.45564690232276917, -0.46756604313850403, 0.1919306516647339, 0.46705254912376404, -0.4126361608505249, -0.443758100271225, 0.10969951003789902, 0.04938659444451332, -0.1734500229358673, -0.4088645279407501, 0.27891477942466736, -0.5784389972686768, 0.4733123481273651, -0.5041479468345642, -0.046972475945949554, -0.052047137171030045, 0.5143409967422485, -0.20675992965698242, -0.551231861114502, 0.05005250871181488, -0.4669867157936096, -0.42891451716423035, 1.1930991411209106, -0.05966633930802345, 0.7143134474754333, 0.1862407922744751, 0.2515554130077362, -0.1155838668346405, 0.019663281738758087, -0.1052393987774849, 0.45254048705101013, 0.3398682773113251, 1.1263465881347656, -0.5984322428703308, -0.17449989914894104, 0.037281982600688934, 0.17137855291366577, 0.023297790437936783, 0.6293795704841614, 0.4098355770111084, -0.1814640909433365, -0.3860282003879547, 0.11400780081748962, -0.305782288312912, 0.2147063910961151, -0.2818278670310974, 0.15655562281608582, -0.1890169084072113, 0.036349326372146606, -0.30104175209999084, -0.13518084585666656, 0.44698774814605713, -0.7827187180519104, -0.5757890343666077, -0.1953655630350113, 0.18633222579956055, 0.1685897260904312, -0.2828321158885956, -0.4666501581668854, 0.4233097732067108, 0.4139419496059418, 0.093037448823452, 0.2536599338054657, -0.412786602973938, 0.20970138907432556, 0.39439576864242554, -0.3864489495754242, 0.405916303396225, 0.27308711409568787, 0.1287766396999359, -0.13207495212554932, -0.28492069244384766, -0.20122911036014557, 0.4068564474582672, -0.5779302716255188, 0.3966934382915497, 0.10067642480134964, 0.11149542778730392, -0.21950554847717285, 0.10804619640111923, -0.14795340597629547, -1.0374964475631714, -0.0518982820212841, 0.199809268116951, -0.2593928873538971, 0.2079404890537262, 0.13928315043449402, 0.20767444372177124, 0.6084784269332886, -0.23350100219249725, -0.10485716164112091, -0.3503616452217102, -0.0981886088848114, 0.29061007499694824, -0.8047730922698975, 0.9194760322570801, 0.010111425071954727, -0.3284420669078827, 1.3400336503982544, 0.2273143082857132, 0.2773519456386566, 0.1728324443101883, 0.1930626630783081, 0.25458359718322754, -0.024796275421977043, -0.26662445068359375, 0.15802310407161713, 0.044508639723062515, 0.07687333226203918, -0.242933988571167, 0.05221226066350937, 0.38805460929870605, -0.5416359901428223, -0.07447881996631622, 0.27144894003868103, -0.08858275413513184, -0.3233124613761902, 0.2798108160495758, -0.23035049438476562, -0.5494766235351562, -0.05475342646241188, 0.31158989667892456, -0.4416375756263733, 0.519677460193634, 0.5962870121002197, 0.3311537802219391, 1.047645926475525, 0.5863549709320068, 0.09381537139415741, 1.0430176258087158, -0.38072481751441956, -0.2392551302909851, -0.3675245940685272, 0.2679593563079834, -0.1647338569164276, 0.14267833530902863, 0.3930721580982208, 0.2144974172115326, 0.06271112710237503, 0.26290473341941833, 0.13406305015087128, -0.15622425079345703, 0.17511126399040222, -0.4802711009979248, -0.011910448782145977, 0.2557888627052307, -0.2438695877790451, -0.3159348964691162, 0.48405221104621887, -1.10139799118042, -0.07715936750173569, 0.21983158588409424, 0.19596131145954132, 0.4005887508392334, -0.5231025218963623, -0.05278955399990082, 0.2806958854198456, -0.5274487733840942, -0.5454853177070618, 0.09812027961015701, -0.1406751275062561, -0.16282589733600616, 0.13941702246665955, 0.247891366481781, 0.46340319514274597, -0.14776702225208282, 0.11223920434713364, -0.7531224489212036, -0.2831352651119232, 1.0829709768295288, 0.3270586431026459, 0.8434382677078247, 0.13823528587818146, -0.9928611516952515, 0.11502574384212494, -0.26038873195648193, -0.2994483411312103, -0.37671592831611633, 0.7373889684677124, -0.6460696458816528, -0.21958498656749725, 0.14937998354434967, 0.37329113483428955, 0.3720560371875763, -0.2554527819156647, -0.5774868726730347, 0.05854574218392372, -0.3827363848686218, -0.34546443819999695, -0.6871944069862366, -0.4463498592376709, -0.485971063375473, 0.8281810283660889, -0.17134198546409607, 0.14676333963871002, 0.20439086854457855, -0.2074958235025406, 0.17785973846912384, -0.03373406454920769, 0.8080683350563049, 0.019215159118175507, 0.1810193657875061, 0.6159728169441223, -0.30768153071403503, 0.01797003485262394, -0.13159561157226562, 0.3154343068599701, -0.006890946999192238, -0.24131852388381958, -5.782351970672607, 0.4170844554901123, 0.1311083436012268, -0.19160808622837067, 0.2804756462574005, -0.4378162622451782, 1.183247447013855, 0.31204020977020264, 0.19113023579120636, 0.2927219271659851, 0.21134072542190552, 0.4134342670440674, 0.005196996033191681, -0.07072984427213669, -0.46422091126441956, 0.03005591221153736, 0.10698606073856354, -0.27322518825531006, 0.6433147192001343, 0.006887288298457861, -0.2615152597427368, 0.03740539401769638, 0.34627288579940796, 0.14376667141914368, 0.01799943670630455, -0.1547153890132904, -0.6306124329566956, -0.06212332099676132, -0.529559314250946, -0.6174614429473877, 0.4137446880340576, -0.4001755118370056, 0.3819529414176941, -0.24789319932460785, -0.07872354239225388, 0.04365510120987892, 0.19687165319919586, -0.0388089194893837, -0.13241107761859894, -0.2162567526102066, 0.18357108533382416, 0.1324579417705536, -0.09146126359701157, 0.10635433346033096, 0.3440070152282715, 0.29375359416007996, 0.19312816858291626, -0.1122426763176918, 0.08022850006818771, 0.8054319024085999, -0.2848072648048401, 0.02243395335972309, 0.33426225185394287, 0.6220762133598328, 0.4791213572025299, 0.16823063790798187, -0.3875153064727783, 0.21320748329162598, -0.8269314169883728, -0.10002180188894272, -0.4032405614852905, 0.028027230873703957, -0.4771086573600769, -0.7798336148262024, 0.22512009739875793, 0.11513131856918335, -0.2295047789812088, -0.20989356935024261, 0.7639197707176208, -0.36541613936424255, -0.35789212584495544, 0.05564876273274422, 0.8500341773033142, -0.4316825270652771, 1.0239983797073364, -0.3829827606678009, -0.23142094910144806, -0.03234647586941719, -0.17396622896194458, -0.07389599829912186, -0.3450388014316559, -0.28147175908088684, 0.01980525441467762, -0.10962627828121185, 0.19574792683124542, -0.2123740017414093, 0.16943329572677612, 0.3548773229122162, 0.012458148412406445, 0.41803497076034546, 0.6310603618621826, 0.36723828315734863, -0.12647701799869537, 0.5518674850463867, 0.1852705478668213, 0.714640200138092, 0.2727052867412567, 0.9198415279388428, 0.6156015396118164, 0.4549762010574341, 0.548099935054779, -0.2759413421154022, -0.2733081579208374, -0.8756063580513, 0.06797803938388824, -0.11163625121116638, -0.5620253086090088, -0.0902935042977333, 0.47783297300338745, -0.8937116265296936, 0.19558559358119965, -0.05477847158908844, -0.5934092998504639, -0.019763147458434105, 0.7155761122703552, -0.4639759063720703, 0.12300488352775574, 0.017967471852898598, 0.3960860073566437, -0.22652612626552582, 0.4331231117248535, 0.44199615716934204, -0.8685052394866943, 0.41295814514160156, 0.09003327786922455, -0.2158348113298416, 0.2999018430709839, 0.5482040643692017, -0.8472805023193359, -0.34392887353897095, 0.25935766100883484, 0.2043757140636444, -0.5140500664710999, -0.15007668733596802, 0.24372386932373047, -0.27551332116127014, -0.8293768763542175, 0.6015053987503052, -0.07690832763910294, -0.12245336174964905, 0.343180388212204, -0.32707974314689636, 0.03551943972706795, 0.016501301899552345, 0.5174766182899475, 0.05520853027701378, 0.2695605754852295, 0.11441604793071747, -0.21490895748138428, -0.30792832374572754, 0.402391642332077, -0.37150824069976807, 0.30376186966896057, -0.06975827366113663, -0.36484768986701965, 0.9064095616340637, 0.25784677267074585, -0.057061273604631424, -0.09945838153362274, -0.5468786954879761, 0.11927719414234161, 0.4163481593132019, -0.7860373258590698, 0.32531416416168213, 0.30126920342445374, -0.10048586130142212, 0.01226914394646883, -0.8835132718086243, -0.17424242198467255, 0.3067300617694855, -0.29025793075561523, 0.25588753819465637, -0.05502639710903168, -0.026011262089014053, 0.12482105195522308, 0.16489055752754211, -0.3884463906288147, 0.1406426578760147, 0.12146221101284027, 0.32272499799728394, 0.09684707224369049, 0.11292614042758942, -0.3426964282989502, 0.654992401599884, 0.5835230946540833, 0.16822485625743866, -0.07406952232122421, -0.0812026634812355, -0.3339216709136963, -0.33468708395957947, 0.09291590750217438, -0.05785498768091202, 1.093308687210083, -0.07608237117528915, -0.05616798251867294, 0.12353258579969406, 0.023231547325849533, 0.5699006915092468, -0.05473700538277626, -0.6347888708114624, 0.14547787606716156, 0.11618699878454208, -0.3270547091960907, -0.10934972018003464, 0.39216098189353943, -0.28435635566711426, -0.08579733967781067, -0.13126404583454132, -0.32992151379585266, -0.43286678194999695, -0.28266656398773193, -0.8529172539710999, -0.3391379714012146, 0.25430047512054443, 0.4422183334827423, -0.16382943093776703, -0.022711867466568947, -0.47551700472831726, -0.06246363744139671, 0.3742595911026001, 0.5198405981063843, -0.02327927015721798, 0.4320012629032135, 0.3142540454864502, -0.803024411201477, -0.277416855096817, 0.027300601825118065, -0.7961866855621338, 0.5026018619537354, -0.25331348180770874, -0.05546974763274193, -0.053718604147434235, -0.11077392101287842, 0.3283425271511078, -0.7354766726493835, -0.5325581431388855, 0.2204739898443222, 0.497903972864151, 0.24441462755203247, 0.22833813726902008, 0.5681038498878479, 0.3874509632587433, -0.4166097939014435, -0.29174894094467163, -0.5407879948616028, 0.1772294044494629, -0.016697892919182777, -0.4451543092727661, -0.44521838426589966, 0.4986662268638611, 0.34958699345588684, -0.006111584138125181, 0.13074372708797455, 0.14149446785449982, 0.9106418490409851, -0.35852569341659546, -0.0858943983912468, -0.6374909281730652, -0.3594372272491455, -0.03405141830444336, -0.5503144860267639, -0.15197615325450897, 0.4343489706516266, 0.02884715609252453, 0.05137813836336136, -0.10200023651123047, -0.010520683601498604, -0.7514986991882324, 0.38020145893096924, -0.54563969373703, -0.31278711557388306, -0.1268809735774994, 0.3356596827507019, -0.026266304776072502, -0.35596156120300293, 0.49076464772224426, -0.31818774342536926, 0.041315022855997086, 0.25712552666664124, 0.2165103703737259, -0.19743579626083374, -0.6313232183456421, 0.2028319388628006, -0.6331608295440674, -0.39387592673301697, -0.4999591112136841, 0.17889830470085144, -0.715526819229126, 0.05319063737988472, -0.22051198780536652, -0.5620227456092834, 0.10716629028320312, -0.4954085648059845, -0.7244018912315369, -0.014939733780920506, -0.3216475546360016, -0.1529933512210846, 0.24546398222446442, -0.18270447850227356, 0.03363947197794914, -0.2740328311920166, -0.16846486926078796, 0.8605591654777527, -0.356925904750824, -0.432989239692688, 0.3935110867023468, -0.04301008954644203, 0.06982038170099258, -0.28090497851371765, -0.22022566199302673, -0.18684865534305573, -0.08459393680095673, 0.5412826538085938, -0.13830812275409698, -0.4035624563694, -0.009531077928841114, -0.2622135877609253, -0.18765170872211456, 0.1894664317369461, 0.13459551334381104, 0.22706545889377594, 0.1565350443124771, 0.1441553831100464, -0.16218407452106476, -0.0856647714972496, 0.3634348213672638, 0.3227788507938385, 0.14552396535873413, 0.07956960797309875, 0.805772066116333, 0.12905766069889069, -0.0744180679321289, 0.0801868736743927, 0.7160934209823608, 0.1588260680437088, 0.297475665807724, 0.30168697237968445, -0.5477368235588074, -0.22337846457958221, -0.14312316477298737, 0.743394136428833, 0.7620572447776794, -0.07909507304430008, -0.14122311770915985, 0.723588764667511, 0.04673562943935394, -0.257132351398468, -0.10827688127756119, 0.09831499308347702, 0.18704861402511597, 0.1646500527858734, -0.6275519728660583, -0.4404009282588959, 0.339674174785614, -0.631931722164154, -0.02584494836628437, 0.26504406332969666, -0.5188518762588501, -0.3580593168735504, 0.13986548781394958, -0.2657434940338135, -0.0031723822467029095, -0.4408476948738098, 0.4007340669631958, -0.186866894364357, -0.4898113012313843, 0.5969820618629456, 0.4849468767642975, 0.21120589971542358, 0.06685936450958252, 0.36786508560180664, -0.21458926796913147, -0.32343095541000366, -0.1787509173154831, 0.07351353764533997, -0.36311182379722595, 0.7112021446228027, 0.015859048813581467, -0.005926590878516436, 0.3496203124523163, -0.5246321558952332, 0.2105550318956375, -0.49935105443000793, -0.3615313768386841, -0.5418222546577454, -0.4818652272224426, -0.46097269654273987, -0.02174718677997589, 0.0587918795645237, 0.30710771679878235, -0.03010382689535618, -0.5209309458732605, -0.001255046227015555, 0.3485190272331238, -0.22442159056663513, -0.42837345600128174, -0.00006159957411000505, -0.039701879024505615, 0.3667021095752716, 0.7333329916000366, 0.043443355709314346, 0.11983916163444519, -0.09716325253248215, 0.43720778822898865, -0.7273765206336975, 0.7948347926139832, -0.3139120042324066, -0.1457255333662033, -0.5498006939888, -0.3268786668777466, 1.1043928861618042, 0.9765669703483582, -0.2269347757101059, 0.00859876349568367, 0.048023585230112076, -0.060263343155384064, 0.31495368480682373, -0.5416578650474548, -0.4256118834018707, -0.4720641076564789, -0.09298563748598099, -0.5568484663963318, 0.8853437900543213, -0.20394809544086456, -0.5093596577644348, -0.300556480884552, 0.7006300687789917, 0.36794185638427734, -0.3369559645652771, 0.34329378604888916, -0.6457363963127136, -0.009201625362038612, 0.018831543624401093, 0.2855784296989441, -0.6689695715904236, 0.10989346355199814, -0.2222692221403122, 0.09123071283102036, 0.15333685278892517, 0.1836753487586975, 0.058121614158153534, -0.04028290510177612, -0.08129849284887314, -0.12922699749469757, 0.19324585795402527, 0.07789799571037292, -0.16332760453224182, -0.36006778478622437, -0.2071244716644287, 0.1572633534669876, 0.027959367260336876, -0.12953458726406097, -0.2027381956577301, 0.2767127454280853, 0.024404076859354973, -0.29027995467185974, -0.13255934417247772, -0.20657692849636078, -0.3030538260936737, -0.0509711317718029 ]
The popularization of genome-wide analyses and RNA sequencing led to the discovery that a large part of the human genome, while effectively transcribed, does not encode proteins. Long non-coding RNAs have emerged as critical regulators of gene expression in both normal and disease states. Studies of long non-coding RNAs expressed in the heart, in combination with gene association studies, revealed that these molecules are regulated during cardiovascular development and disease. Some long non-coding RNAs have been functionally implicated in cardiac pathophysiology and constitute potential therapeutic targets. Here, we review the current knowledge of the function of long non-coding RNAs in the cardiovascular system, with an emphasis on cardiovascular development and biology, focusing on hypertension, coronary artery disease, myocardial infarction, ischemia, and heart failure. We discuss potential therapeutic implications and the challenges of long non-coding RNA research, with directions for future research and translational focus.
[ 0.025751056149601936, 0.02261388674378395, -0.011876954697072506, 0.018932953476905823, 0.001376684638671577, -0.015415087342262268, 0.010254202410578728, -0.002403225051239133, -0.017405392602086067, -0.006958103273063898, -0.0028047380037605762, 0.014733527787029743, 0.011227233335375786, 0.012837101705372334, -0.012989509850740433, 0.01244729571044445, -0.01448536105453968, 0.010044900700449944, 0.009601064026355743, 0.03904763236641884, -0.005601170472800732, -0.026785561814904213, 0.010398441925644875, 0.009351057931780815, 0.022073552012443542, 0.0030101595912128687, 0.010004682466387749, 0.0017161550931632519, -0.006216025445610285, 0.00942742545157671, 0.010197633877396584, 0.005216146819293499, 0.029631357640028, 0.023073691874742508, 0.009994043037295341, -0.022280707955360413, 0.0021379615645855665, 0.020607296377420425, 0.07542246580123901, -0.003466939553618431, 0.02134690433740616, -0.009739568457007408, 0.005408226512372494, 0.0020073694176971912, -0.004584752023220062, 0.003940136171877384, -0.0040467227809131145, 0.0217767134308815, -0.007300104945898056, 0.011723171919584274, -0.007123489864170551, -0.024772465229034424, -0.019951114431023598, 0.021219436079263687, -0.006640555802732706, 0.011767420917749405, 0.020484667271375656, 0.03447902575135231, -0.02858145534992218, 0.00639025354757905, 0.013533355668187141, 0.008750790730118752, 0.010718238539993763, -0.012175195850431919, 0.000850162236019969, -0.06658773124217987, 0.018936943262815475, 0.021209726110100746, -0.0161922387778759, -0.005455671809613705, 0.01617950201034546, 0.014553518034517765, -0.013497616164386272, -0.016251876950263977, 0.0026559275574982166, 0.016302358359098434, 0.0015569506213068962, 0.0025639566592872143, 0.026115406304597855, -0.005461305379867554, -0.030395230278372765, 0.003098581451922655, -0.015184413641691208, 0.02001585252583027, 0.023922061547636986, 0.010759178549051285, -0.01564677059650421, -0.004225455690175295, 0.03085700236260891, -0.007576133124530315, 0.012985698878765106, 0.013139836490154266, -0.0399661548435688, 0.014977997168898582, -0.00809125043451786, 0.018706064671278, -0.00408603111281991, -0.0045110611245036125, 0.0393790528178215, 0.011272531934082508, -0.001919926842674613, -0.0015004916349425912, 0.018287450075149536, 0.008572541177272797, -0.03884628042578697, 0.011115709319710732, 0.048566967248916626, 0.02987576648592949, -0.005079453811049461, 0.00715373270213604, 0.0005668704397976398, 0.01284254714846611, 0.005347564350813627, -0.004426861181855202, 0.0374189093708992, 0.03559768572449684, -0.01480923406779766, 0.020767400041222572, 0.008106445893645287, -0.014464426785707474, -0.026102399453520775, 0.0005830535665154457, 0.011925103142857552, 0.03207718953490257, 0.006366170942783356, -0.021814309060573578, -0.007017361465841532, -0.0021121175959706306, -0.020091215148568153, 0.023276977241039276, -0.007222282700240612, 0.0026452098973095417, -0.05084237456321716, -0.02683999016880989, -0.00582822784781456, -0.017757155001163483, 0.01635805144906044, 0.010003739967942238, 0.00209611258469522, -0.017605405300855637, 0.013245895504951477, 0.01036468893289566, 0.002893329132348299, 0.01601819507777691, 0.04449835419654846, -0.004401001147925854, 0.033886998891830444, 0.00844850018620491, 0.017620492726564407, -0.022927770391106606, -0.021199436858296394, 0.012438710778951645, 0.02670292928814888, -0.017945528030395508, 0.022109709680080414, 0.032134100794792175, -0.022502366453409195, -0.04297010228037834, -0.015577388927340508, 0.02358562871813774, -0.0032469104044139385, -0.00668192096054554, 0.005277737975120544, 0.007794524542987347, -0.021346978843212128, -0.019974250346422195, 0.011810775846242905, -0.004707313142716885, 0.007233376614749432, 0.0045532481744885445, 0.004899144172668457, -0.02340913563966751, 0.0043242014944553375, 0.012594936415553093, -0.032326485961675644, -0.012384814210236073, 0.016203725710511208, 0.0084755327552557, -0.009591566398739815, 0.06632009148597717, -0.012234259396791458, 0.021601546555757523, -0.0069575621746480465, -0.003532777540385723, 0.010874353349208832, -0.007105638738721609, 0.0020904275588691235, -0.006784581579267979, -0.0067648449912667274, 0.008496887981891632, 0.01769828610122204, 0.0034197927452623844, -0.002451726235449314, -0.02224740758538246, -0.00640967208892107, 0.0030677122995257378, 0.01364130713045597, -0.011187034659087658, -0.015988841652870178, -0.003822829807177186, 0.00497477687895298, 0.008513742126524448, -0.005158029496669769, -0.020015407353639603, -0.014433499425649643, 0.003868871834129095, 0.012911796569824219, -0.009137555956840515, -0.0009593542199581861, 0.023610420525074005, 0.03215309977531433, 0.009612912312150002, -0.005491657182574272, -0.01348109170794487, 0.00813606008887291, 0.0009619076736271381, -0.025197401642799377, 0.025128625333309174, 0.01986556686460972, -0.016989143565297127, 0.009766604751348495, 0.008338717743754387, -0.04362495616078377, -0.01847200095653534, 0.0075503140687942505, 0.02080947533249855, 0.028407959267497063, 0.010814614593982697, 0.005123746581375599, 0.009968413040041924, -0.001330450177192688, -0.024685705080628395, -0.006305048707872629, 0.011249300092458725, 0.035536058247089386, -0.014901278540492058, 0.007545924745500088, -0.0068904934450984, 0.008473469875752926, -0.007142635993659496, -0.022338006645441055, -0.01379454042762518, -0.018397200852632523, -0.010558727197349072, 0.005519483238458633, -0.018290817737579346, -0.0006271664751693606, 0.012100771069526672, 0.02040233090519905, -0.019951187074184418, 0.006676797289401293, -0.011655619367957115, 0.014747098088264465, -0.0035838373005390167, 0.0024861255660653114, 0.022108247503638268, 0.014666983857750893, -0.014274151995778084, 0.025020863860845566, -0.0065963682718575, 0.00835314393043518, 0.003324351739138365, 0.01500215008854866, -0.015415322966873646, -0.02935103327035904, 0.010565804317593575, -0.005422648973762989, 0.011219264939427376, 0.008341490291059017, -0.013542107306420803, 0.008979551494121552, -0.010619531385600567, -0.0032930350862443447, -0.0810290053486824, 0.004083122592419386, 0.013010313734412193, 0.014356013387441635, 0.01224789023399353, 0.0035839704796671867, 0.005310108885169029, 0.02935478836297989, -0.007687235251069069, -0.02962704747915268, 0.006751722656190395, -0.009431051090359688, -0.010892942547798157, 0.019016701728105545, 0.023496214300394058, -0.013918353244662285, 0.00544443866237998, 0.006799413822591305, -0.03730352222919464, -0.03354087471961975, -0.025132089853286743, -0.003298041643574834, 0.011332031339406967, 0.0024805194698274136, -0.027973681688308716, 0.02490425482392311, -0.022930344566702843, -0.010449709370732307, 0.005760766565799713, 0.013518917374312878, -0.015919756144285202, -0.02223893813788891, 0.0362028032541275, -0.0016112423036247492, 0.0008458567317575216, -0.005441215820610523, -0.024755045771598816, 0.00619110744446516, -0.025387486442923546, 0.026477240025997162, 0.004379191901534796, 0.01976899802684784, 0.022377805784344673, -0.009806428104639053, 0.019833281636238098, 0.019699273630976677, 0.01329252403229475, 0.04434369504451752, 0.010629070922732353, -0.0031666504219174385, 0.010454812087118626, -0.0007349986699409783, 0.023289088159799576, 0.015604589134454727, -0.008863391354680061, 0.01463666558265686, -0.012876125052571297, -0.007911216467618942, -0.021596169099211693, -0.018777254968881607, -0.0006167258834466338, 0.025142785161733627, 0.03396591544151306, -0.015757594257593155, 0.022430267184972763, 0.008519718423485756, 0.007738466374576092, 0.010615627281367779, -0.023013310506939888, 0.020550506189465523, 0.008436507545411587, -0.016418766230344772, 0.004034931771457195, -0.009327943436801434, -0.01962331309914589, -0.009209510870277882, -0.012098444625735283, -0.00510224886238575, -0.010114196687936783, 0.0036786331329494715, 0.001410983270034194, 0.021044647321105003, -0.019488563761115074, 0.01742248423397541, -0.016792848706245422, -0.05860021710395813, 0.004721333738416433, 0.004009793512523174, 0.01098373532295227, -0.02666451781988144, 0.010524148121476173, 0.034586239606142044, 0.03346799686551094, 0.008464327082037926, -0.021914027631282806, -0.04968497157096863, 0.010351123288273811, -0.00005537274410016835, -0.002729961648583412, 0.009335263632237911, -0.044723302125930786, 0.005091759376227856, 0.02802472747862339, -0.014519000425934792, -0.016331205144524574, 0.01800968125462532, -0.010479201562702656, -0.011274673044681549, 0.015907544642686844, -0.006672917865216732, -0.020937025547027588, 0.005634737201035023, -0.012666693888604641, 0.03333747386932373, 0.01057091448456049, 0.001650101039558649, 0.01963859051465988, -0.007794508710503578, 0.07160075008869171, 0.008597126230597496, 0.00005720334593206644, -0.015151523053646088, -0.0015584048815071583, -0.011655047535896301, -0.009447083808481693, 0.005279993638396263, 0.010057351551949978, -0.007415645755827427, 0.01334155723452568, -0.021240821108222008, -0.00024244468659162521, -0.006197725422680378, -0.0014515271177515388, -0.019244473427534103, 0.01998141035437584, -0.02042701095342636, 0.01490871887654066, 0.024907216429710388, -0.014658842235803604, -0.02841157093644142, -0.008272637613117695, -0.00005988974589854479, -0.011080252006649971, -0.01409260742366314, 0.02620004490017891, -0.013355053961277008, -0.004701872356235981, 0.006447196006774902, 0.02532896213233471, -0.007712309714406729, 0.000325614120811224, 0.024818889796733856, -0.015646733343601227, -0.009110861457884312, 0.032451875507831573, -0.0032352162525057793, -0.019872162491083145, 0.010755402967333794, 0.015339398756623268, -0.015372180379927158, 0.01705475151538849, 0.020147094503045082, 0.015252063050866127, 0.014404293149709702, 0.02453043684363365, -0.005092287436127663, -0.008739677257835865, 0.043483976274728775, -0.0010794347617775202, 0.006009390112012625, 0.0077028716914355755, 0.007281178142875433, -0.017457831650972366, -0.011310004629194736, 0.015233900398015976, -0.011629068292677402, 0.021898634731769562, 0.01797378808259964, -0.0023072059266269207, -0.010595269501209259, -0.010077379643917084, 0.001613460946828127, -0.015574917197227478, -0.009753730148077011, -0.013209632597863674, -0.013912759721279144, -0.024622246623039246, -0.026469793170690536, -0.006923695560544729, -0.006226870231330395, -0.025570258498191833, 0.0004874458536505699, -0.02442341484129429, -0.02575089782476425, 0.010053887963294983, 0.008044691756367683, -0.011158851906657219, -0.013855990953743458, 0.015655841678380966, 0.046553030610084534, 0.016827140003442764, 0.013516339473426342, 0.016941258683800697, -0.019026339054107666, -0.03443154692649841, -0.07428526878356934, -0.027004007250070572, 0.035125236958265305, -0.010553214699029922, 0.012446257285773754, 0.025134587660431862, -0.03295491263270378, 0.005907773040235043, 0.0006846063770353794, 0.003841011319309473, 0.012972502037882805, 0.01805925741791725, 0.02377176284790039, -0.007194951642304659, 0.01436653733253479, 0.025813061743974686, 0.0015720031224191189, -0.004843703471124172, 0.011484181508421898, 0.013459622859954834, -0.018108835443854332, 0.007759936153888702, -0.001257483847439289, 0.004054388031363487, -0.009594390168786049, -0.0806535854935646, -0.020335612818598747, 0.016471918672323227, -0.0191277377307415, -0.02828211709856987, 0.02156396582722664, 0.034268781542778015, -0.03391695022583008, 0.012832846492528915, -0.020576972514390945, -0.015098148956894875, 0.037248644977808, -0.013849874958395958, 0.0030524996109306812, 0.020878037437796593, -0.0058545200154185295, 0.03373190015554428, 0.03707404062151909, -0.03227320313453674, -0.006467776373028755, -0.0123428450897336, 0.008977971971035004, -0.012260819785296917, 0.016003640368580818, -0.013110378757119179, -0.05844416841864586, -0.007030170410871506, 0.015042605809867382, 0.02206406742334366, -0.0011005984852090478, -0.0031540393829345703, 0.00007988256402313709, -0.013185417279601097, -0.009305382147431374, -0.010524020530283451, -0.01797519624233246, -0.012546822428703308, -0.007519995328038931, -0.029960423707962036, 0.004713833332061768, -0.009551158174872398, -0.025928501039743423, -0.022299109026789665, 0.02698902040719986, 0.011504707857966423, -0.04937446117401123, 0.004438258707523346, -0.009216373786330223, 0.011208424344658852, 0.000919634010642767, 0.005649465136229992, 0.020918086171150208, 0.02419261448085308, -0.012068632990121841, 0.009931947104632854, 0.02686893753707409, -0.011323855258524418, 0.0017266521463170648, 0.009435824118554592, 0.006655476056039333, -0.016196833923459053, 0.005037734750658274, 0.016485292464494705, 0.07107076048851013, -0.004102024715393782, 0.009625333361327648, -0.011514020152390003, -0.010306543670594692, 0.0005600157892331481, -0.03796985745429993, -0.006917371414601803, -0.0026107702869921923, 0.0036083469167351723, 0.011936629191040993, -0.010117072612047195, -0.0067817410454154015, 0.014217568561434746, -0.006534877233207226, 0.02730899676680565, 0.0005694101564586163, 0.014230329543352127, -0.01590222492814064, -0.0002524303272366524, -0.022157981991767883, -0.011622907593846321, -0.021897584199905396, 0.01721925288438797, -0.0045878044329583645, -0.01323025394231081, -0.025655006989836693, -0.014861267060041428, -0.02158130332827568, 0.01663278043270111, 0.001482806634157896, 0.016316261142492294, 0.0021094540134072304, -0.008219549432396889, 0.02456551417708397, -0.019891077652573586, -0.00280547421425581, -0.0035312497057020664, -0.0004542814567685127, -0.0006892816163599491, -0.005543727893382311, -0.01364041306078434, 0.008853303268551826, 0.017699342221021652, 0.02214517630636692, -0.005143980961292982, 0.0251116044819355, 0.007189463824033737, 0.030879080295562744, 0.012044930830597878, 0.029113348573446274, -0.004446969833225012, -0.00154751050285995, -0.023672670125961304, 0.016621805727481842, -0.008697491139173508, 0.006606353912502527, 0.01714683696627617, 0.02232414297759533, -0.017229963093996048, 0.0024929156061261892, -0.016227994114160538, -0.001740213017910719, -0.024890907108783722, 0.003992147743701935, -0.01579074189066887, -0.021385416388511658, -0.012825507670640945, 0.007606492377817631, 0.02158334106206894, 0.0005768490955233574, 0.003145907074213028, 0.007809046655893326, 0.01206260360777378, 0.04325171560049057, -0.009084672667086124, 0.009654075838625431, -0.006504646968096495, 0.01563285104930401, 0.009386913850903511, -0.011957448907196522, 0.009880420751869678, -0.003089762991294265, -0.005582304205745459, -0.05788206681609154, 0.02379586175084114, -0.005455231759697199, -0.018277477473020554, -0.008904693648219109, 0.008992036804556847, 0.0103411003947258, -0.0010992024326696992, 0.00463654613122344, -0.00670786015689373, 0.008363571017980576, 0.03549709916114807, 0.002121551660820842, 0.005014099180698395, -0.015580089762806892, -0.0037082924973219633, 0.026559673249721527, 0.009997298941016197, 0.015064708888530731, 0.028803130611777306, -0.017733633518218994, -0.0034154620952904224, -0.011544039472937584, -0.022845664992928505, -0.0026892381720244884, -0.008953195065259933, 0.023031553253531456, -0.008882153779268265, 0.0024039065465331078, 0.006172382738441229, 0.036778517067432404, 0.033433377742767334, -0.007476435042917728, -0.0454479455947876, 0.017424169927835464, -0.014402186498045921, -0.010211395099759102, -0.027099769562482834, 0.015416761860251427, 0.03986481577157974, 0.02011023834347725, -0.017477499321103096, -0.008851837366819382, 0.006064039655029774, 0.015444203279912472, -0.0173606239259243, 0.014231527224183083, 0.01791980490088463, -0.012778369709849358, 0.011015014722943306, 0.027890456840395927, 0.03619392216205597, -0.010821019299328327, 0.011071170680224895, -0.03614488244056702, 0.012229429557919502, 0.01898077316582203, -0.02849777787923813, -0.007713828235864639, -0.004741107113659382, 0.0113222636282444, 0.003360298229381442, -0.0050020781345665455, 0.021592289209365845, 0.010292047634720802, 0.032128218561410904, 0.0012616370804607868, 0.019009603187441826, 0.009007737040519714, -0.007748953998088837, 0.00018700351938605309, 0.01201082393527031, 0.010120891034603119, -0.020052138715982437, -0.01596580632030964, 0.014729917980730534, 0.01716235652565956, 0.029824353754520416, 0.00299408589489758, 0.009573090821504593, -0.008099102415144444, -0.0035460898652672768, 0.007515609730035067, 0.003694717073813081, -0.001909000100567937, 0.0022096005268394947, 0.005447106435894966, 0.008893430233001709, 0.013339871540665627, 0.012654823251068592, -0.029409965500235558, -0.016526836901903152, -0.013082707300782204, 0.0032267365604639053, -0.004177304916083813, -0.0033921487629413605, 0.003959337715059519, -0.04037830978631973, -0.011854440905153751, -0.005807369016110897, 0.005574480164796114, -0.0006922665052115917, 0.00018227053806185722, -0.029169805347919464, 0.015995115041732788, 0.005325931124389172, -0.006158757489174604, 0.020219959318637848, -0.0253995880484581, -0.0015064668841660023, 0.004178502131253481, -0.020355425775051117, 0.01174237485975027, -0.010935850441455841, 0.01646723411977291, 0.01309230923652649, 0.023177679628133774, -0.004892063792794943 ]
[ 0.5188305377960205, 0.15726806223392487, -0.18486101925373077, 0.019454069435596466, 0.3145153522491455, -0.22913558781147003, 0.11904135346412659, -0.018242623656988144, -0.047113191336393356, -0.465963751077652, -0.04030558094382286, 0.22501574456691742, -0.7439542412757874, 0.49472999572753906, -0.10451123863458633, 0.602475643157959, 0.20030216872692108, 0.5283617973327637, 0.0037509812973439693, -0.506137490272522, -0.3142125606536865, -0.08108460903167725, 0.5701729655265808, -0.11151123046875, 0.21520449221134186, -0.25153812766075134, 0.2566840350627899, -0.16312803328037262, -0.046685971319675446, -0.026268986985087395, -0.14562273025512695, 0.2771475613117218, -0.03958866745233536, 0.24055801331996918, -0.13270525634288788, -0.07070255279541016, -0.34583741426467896, 0.16400709748268127, -0.13263167440891266, 0.10075659304857254, -0.1691979020833969, -0.19695834815502167, -0.1463846117258072, 0.5390169024467468, -0.23236779868602753, -0.5429030656814575, -1.1247000694274902, 0.8872381448745728, -0.3219955563545227, 0.11970867961645126, -0.1916337013244629, 0.06458401679992676, 0.45943519473075867, 0.09262123703956604, 0.3702600598335266, 0.1796385943889618, -0.20115314424037933, -0.22641637921333313, 0.25269755721092224, -0.49064773321151733, 0.36684277653694153, -0.059859100729227066, -0.6108461618423462, 0.2602211534976959, 0.1930638700723648, 0.5061833262443542, 0.008398393169045448, -0.8894266486167908, -0.6953057646751404, -0.5173019170761108, 0.06351083517074585, -0.3457382917404175, -0.06272830814123154, 0.3650718927383423, -0.28955844044685364, -0.21724256873130798, -0.15551668405532837, -0.1353623867034912, 0.17850449681282043, -0.23875392973423004, 0.1462198793888092, 0.21790848672389984, -0.07283543050289154, 0.1282271444797516, 0.01599084958434105, -0.04191560670733452, -0.3933730125427246, 0.3807583451271057, -0.3770223557949066, -0.1451694816350937, 0.04600987210869789, 0.09462083131074905, 0.09691020101308823, 0.17443232238292694, 0.1723642796278, 0.35692712664604187, 0.061797503381967545, -0.04009473696351051, -0.0054365601390600204, 0.5248347520828247, -0.24434073269367218, -0.38223370909690857, 0.37055131793022156, -0.6679508686065674, -0.2704117000102997, -0.24918772280216217, 0.005322451237589121, -0.4613068103790283, -0.1452481746673584, 0.12082681059837341, -0.45657244324684143, 0.15669840574264526, -0.02450943924486637, -0.10038483887910843, -0.14053478837013245, 0.43448910117149353, 0.25238293409347534, -0.2298099845647812, 0.11386029422283173, 0.06793296337127686, -0.3423123359680176, 1.298069715499878, -0.24674338102340698, 0.046729832887649536, 0.016268720850348473, -0.30160221457481384, 0.3383788764476776, -0.10018780827522278, -0.38827085494995117, 0.15405157208442688, 0.2978231906890869, 1.2611377239227295, -0.7129110097885132, -0.07539143413305283, -0.1626598984003067, 0.2803225517272949, 0.26742932200431824, -0.07748068869113922, 0.16517868638038635, -0.20295967161655426, -0.6257428526878357, -0.4931001663208008, -0.0983307734131813, -0.1270405799150467, -0.07588665187358856, -0.21863432228565216, -0.21781541407108307, -0.42991453409194946, -0.0531652569770813, -0.2934496998786926, -0.21382474899291992, -0.31033220887184143, -0.3623359799385071, 0.23910292983055115, 0.2516598403453827, 0.07040603458881378, 0.15075278282165527, 0.13436022400856018, 0.07691624760627747, 0.38418149948120117, 0.10336929559707642, -0.25919362902641296, -0.3363129794597626, -0.20235000550746918, 0.37710118293762207, -0.11252449452877045, 0.7032980918884277, 0.7224573493003845, -0.2375754863023758, -0.41647717356681824, -0.3399847745895386, -0.3738921880722046, 0.49197763204574585, -0.6350180506706238, -0.30248209834098816, -0.16539455950260162, -0.11028458923101425, -0.3319733440876007, -0.20929010212421417, 0.22175587713718414, -0.7109718918800354, 0.10865093767642975, -0.1815965622663498, -0.3520776331424713, 0.9015325307846069, 0.10088233649730682, 0.30383798480033875, 0.2579658627510071, -0.38163185119628906, -0.24685950577259064, -0.20832595229148865, -0.42854636907577515, 0.32722917199134827, -0.6789245009422302, 0.9287954568862915, -0.36582595109939575, 0.006154551636427641, 1.811331868171692, -0.06783147901296616, 0.19613802433013916, -0.427761435508728, -0.016781525686383247, 0.5355028510093689, -0.5118152499198914, -0.3527361750602722, 0.21205952763557434, 0.39805668592453003, -0.0795811116695404, 0.22344473004341125, -0.09356248378753662, 0.8624286651611328, -0.29739996790885925, -0.21562732756137848, -0.10048409551382065, 0.05538743734359741, -0.5087544918060303, 0.027964303269982338, 0.02509905956685543, -1.0172557830810547, 0.18665164709091187, 0.44917383790016174, -0.4505855143070221, 0.729464590549469, 1.0457974672317505, -0.15008151531219482, 0.7543919086456299, 0.40881234407424927, 0.2672369182109833, 0.501702070236206, 0.05006648972630501, 0.3456915616989136, -0.81197589635849, 0.1903238445520401, -0.22154097259044647, -0.3865050971508026, 0.18628188967704773, 0.13078735768795013, 0.17664162814617157, -0.08484867960214615, -0.203715518116951, 0.037144605070352554, 0.501586377620697, -0.6799466013908386, -0.23141197860240936, -0.011165120638906956, -0.6370629668235779, -0.2860397696495056, 0.25527748465538025, -0.6567016839981079, -0.36609190702438354, 0.07169283926486969, 0.1502215564250946, 0.5222493410110474, -0.35869213938713074, 0.34825751185417175, 0.1996302306652069, -0.08130739629268646, -0.034796662628650665, 0.4294794201850891, -0.4503220021724701, -0.19718720018863678, 0.01807723566889763, 0.10427729785442352, -0.35316312313079834, -0.548797070980072, -0.20841458439826965, -0.5165724158287048, -0.5958224534988403, 0.8701778650283813, 0.9373112916946411, 0.8875470161437988, 0.11108993738889694, -0.8432130217552185, 0.010980350896716118, 0.0006222003721632063, -0.4384520649909973, 0.37945622205734253, 0.4879624843597412, -0.3659288287162781, 0.01774471439421177, 0.009269779548048973, 0.2696557343006134, 0.8015642762184143, -0.641964852809906, -0.7202464938163757, -0.050136320292949677, 0.021453185006976128, 0.07967164367437363, -0.35414567589759827, 0.3750930726528168, -0.541836678981781, 0.2285907119512558, -0.46792203187942505, -0.19751764833927155, 0.4271557033061981, 0.1883208155632019, 0.1143212765455246, 0.08194416761398315, 0.47807130217552185, -0.023920372128486633, -0.16567498445510864, 0.5231489539146423, -0.16726446151733398, -0.24204862117767334, 0.016814200207591057, 0.22782200574874878, -0.19261617958545685, 0.37009117007255554, -6.008093357086182, 0.021276606246829033, -0.07412558794021606, -0.3471969664096832, -0.31878963112831116, -0.13246944546699524, 0.9077177047729492, 0.01393942628055811, 0.14188866317272186, -0.01601581834256649, 0.2844031751155853, 0.31035977602005005, 0.18435896933078766, -0.012391867116093636, -0.0880264937877655, -0.08694110810756683, 0.03695718199014664, -0.016976598650217056, 0.3482375741004944, 0.18918177485466003, 0.5527732968330383, -0.15690061450004578, 0.0791788175702095, 0.19983641803264618, -0.11990579962730408, -0.2568240761756897, -0.8785728812217712, 0.17323316633701324, -0.027943922206759453, -0.6963456273078918, 0.006139348726719618, -0.1827889084815979, 0.016564866527915, -0.5459386110305786, 0.6051719188690186, -0.027875792235136032, -0.2905323803424835, 0.02892502024769783, 0.28893786668777466, -0.13055290281772614, 0.6583352088928223, 0.17260423302650452, -0.010630271397531033, -0.16725678741931915, 0.08848494291305542, -0.07447300106287003, -0.23557043075561523, 0.4134024977684021, -0.1818534880876541, 0.5656201839447021, -0.2793920636177063, -0.13261759281158447, 0.5780892372131348, 0.33142948150634766, 0.42697757482528687, 0.03821875900030136, 0.03195713087916374, -0.29740580916404724, -0.5869610905647278, -0.12810707092285156, -0.32621192932128906, -0.27757728099823, 0.12016227096319199, -0.550495445728302, 0.05639397352933884, 0.12300637364387512, -0.6464000344276428, -0.6138964891433716, 0.29636478424072266, 0.33634522557258606, -0.4028353691101074, 0.45640119910240173, 0.24595457315444946, -0.5034606456756592, 0.3435903787612915, -0.24708199501037598, 0.25127777457237244, 0.19758795201778412, -0.026532940566539764, -0.03202159330248833, -0.42127367854118347, 0.09249884635210037, -0.481462299823761, -0.09172838181257248, 0.4807974398136139, -0.8489356637001038, -0.41274985671043396, -0.2614239752292633, -0.5170802474021912, 0.6582869291305542, 0.42931869626045227, -0.4324510991573334, 0.3207520544528961, 0.38255348801612854, 0.41194552183151245, -0.04572198539972305, 0.10351578146219254, 0.4512968361377716, 0.5988523364067078, 0.19474099576473236, 0.7647907733917236, 0.40228965878486633, -0.2827209532260895, -1.0248134136199951, 0.07152405381202698, 0.15709015727043152, -0.8011216521263123, 0.4738645553588867, 0.25905388593673706, -0.6771161556243896, -0.1244719922542572, -0.05063975974917412, -0.12165480107069016, -0.08078150451183319, 0.23029720783233643, -0.46838024258613586, 0.04912937805056572, 0.10227048397064209, 0.5490460991859436, -0.2014344334602356, 0.2039814293384552, 0.6451271772384644, -0.25467947125434875, 0.12073151022195816, -0.024174349382519722, -0.07636430114507675, 0.13138128817081451, 0.36562246084213257, -0.5876361727714539, -0.2790573835372925, 0.5545644760131836, 0.4501962661743164, -0.2488090842962265, -0.16837655007839203, 0.2692832946777344, -0.03451685607433319, -0.3465440273284912, 0.5223637223243713, 0.09355422109365463, -0.4841088056564331, 0.3503637909889221, -0.29933086037635803, 0.1394023895263672, -0.06736306101083755, 0.07584787160158157, 0.05434845760464668, 0.40029874444007874, 0.2290566861629486, -0.15151917934417725, -0.14568500220775604, -0.05560525879263878, -0.08551914989948273, 0.1760389804840088, -0.2065364271402359, -0.08630136400461197, 0.08841174840927124, 0.7783197164535522, 0.2171936184167862, 0.3239094018936157, -0.6451675891876221, -0.01828097552061081, 0.3618488609790802, -0.7118720412254333, 0.24310533702373505, -0.2504337430000305, -0.21907301247119904, -0.14255663752555847, -0.009563449770212173, -0.1845533698797226, 0.34148406982421875, -0.5463848114013672, -0.04857514798641205, -0.12280570715665817, -0.20533186197280884, 0.11691762506961823, -0.39552491903305054, 0.10894066840410233, 0.3492281436920166, -0.2199069708585739, 0.23540017008781433, 0.39577677845954895, -0.4425131678581238, -0.10316239297389984, 0.5334459543228149, 0.35057225823402405, 0.17866413295269012, 0.34359192848205566, -0.10470814257860184, -0.39088594913482666, -0.2719780504703522, 0.2072708159685135, 0.21136601269245148, 0.4737526476383209, -0.4849235713481903, 0.12774021923542023, 0.12224037945270538, 0.10965604335069656, 0.5259243845939636, 0.2182920277118683, -0.4735892117023468, 0.3537066876888275, 0.267894446849823, -0.4381859302520752, 0.010578908957540989, 0.378578782081604, 0.14985902607440948, -0.41226139664649963, -0.15342943370342255, 0.09875745326280594, 0.033320993185043335, -0.6124016642570496, -0.6723023653030396, 0.5691531300544739, 0.3317507803440094, -0.10758644342422485, 0.1001611202955246, 0.3816034197807312, 0.0018018814735114574, -0.24551242589950562, 0.06438551098108292, 0.5969268083572388, -0.02722226269543171, -0.06934479624032974, -0.007742664311081171, -0.17233502864837646, 0.131031796336174, -0.021633660420775414, -0.6292311549186707, 0.3923419415950775, 0.32795485854148865, -0.4125579297542572, -0.48779481649398804, 0.1056242361664772, -0.14534622430801392, -0.24861888587474823, -0.6470670104026794, -0.2020389437675476, 0.19613555073738098, -0.24801555275917053, 0.36965376138687134, 0.523313581943512, 0.348865807056427, -0.41866442561149597, -0.13990145921707153, -0.5667633414268494, 0.5224440693855286, 0.2366182655096054, -0.23488721251487732, -0.5519508719444275, 0.21488544344902039, 0.3502803444862366, 0.05523693934082985, 0.04743614047765732, 0.41927313804626465, 0.841969907283783, 0.6025640964508057, 0.07405240833759308, 0.0016189173329621553, -0.05565699189901352, 0.004469693172723055, -0.06451598554849625, -0.09613274037837982, -0.33321434259414673, -0.030052540823817253, 0.4106394648551941, 0.11591062694787979, -0.44849786162376404, -0.6509177684783936, 0.7206125855445862, 0.3829652965068817, -0.17371883988380432, 0.010410565882921219, 0.643323540687561, 0.5454438328742981, -0.24577485024929047, 0.45801419019699097, -0.12788057327270508, 0.4495140612125397, -0.05268709361553192, -0.017251407727599144, -0.4597834050655365, -0.29146072268486023, 0.6046145558357239, -0.6334547400474548, 0.1773299276828766, -0.5612983703613281, 0.21635502576828003, -0.43238404393196106, 0.3516424894332886, -0.6138184666633606, -0.39884379506111145, -0.3432919383049011, -0.8074756264686584, -0.4011819660663605, 0.12012198567390442, -0.17309971153736115, 0.1886359453201294, 0.3347323536872864, -0.09754477441310883, -0.4200870394706726, -0.760963499546051, 0.12874646484851837, 0.6083488464355469, -0.5297220349311829, 0.068000927567482, 0.14484527707099915, 0.2537752091884613, 0.5578265190124512, -0.3586077392101288, 0.09967989474534988, 0.028710750862956047, 0.2024557888507843, 0.6590813398361206, 0.3219519853591919, -0.15146233141422272, -0.015647999942302704, -0.36123842000961304, 0.10492229461669922, 0.5544419884681702, 0.08207684755325317, 0.1573409140110016, -0.06951969116926193, 0.16210369765758514, -0.15848907828330994, -0.4514472484588623, 0.5631684064865112, 0.43291717767715454, 0.07413501292467117, -0.34300968050956726, 0.618030846118927, 0.38595473766326904, 0.2012224644422531, -0.13762904703617096, 0.26962652802467346, 0.024896278977394104, 0.1321640908718109, -0.05772697553038597, -0.593307375907898, 0.023592360317707062, -0.12999728322029114, 0.7313345670700073, 0.10572462528944016, -0.418560653924942, 0.05135628208518028, 0.277216374874115, 0.46972453594207764, -0.11894702911376953, 0.3814244568347931, -0.23754210770130157, 0.022638795897364616, 0.4851917624473572, -0.5003689527511597, -0.21953588724136353, 0.44416654109954834, -0.3500514030456543, -0.23903657495975494, 0.4811140298843384, -0.8042482137680054, -0.10068071633577347, -0.0034019036684185266, -0.4560279846191406, 0.14955636858940125, 0.023985683917999268, 0.6067363023757935, 0.22257347404956818, 0.14367921650409698, 0.6869181990623474, -0.1266411691904068, 0.3154464662075043, -0.5658588409423828, 0.024736063554883003, 0.17733272910118103, -0.319419801235199, 0.11493166536092758, 0.06993676722049713, -0.39826729893684387, 0.30244356393814087, -0.16001561284065247, 0.027583036571741104, -0.17117595672607422, -0.026098109781742096, -0.07086587697267532, 0.07435894012451172, -0.8120242357254028, -0.5809535980224609, -0.2456456422805786, -0.36261963844299316, -0.32001978158950806, 0.03300167992711067, 0.09999153763055801, 0.20593850314617157, -1.1373424530029297, -0.0005917989183217287, -0.07823961228132248, 0.17647431790828705, -0.5764865279197693, -0.06587810814380646, 0.45461028814315796, 0.4239574372768402, 0.13238263130187988, 0.26211899518966675, 0.28163260221481323, 0.16155478358268738, 0.2866213321685791, -0.8048651218414307, 0.5777602791786194, -0.16903401911258698, -0.3419452905654907, -0.4499506950378418, 0.11480460315942764, 1.0028862953186035, 0.3148457705974579, -0.18707144260406494, 0.40332409739494324, 0.19763149321079254, 0.24937529861927032, 0.31910479068756104, -0.7363588809967041, 0.1631464809179306, -0.36668798327445984, 0.07393688708543777, -0.22454367578029633, 0.4744952321052551, 0.06380833685398102, -0.3579815626144409, -0.060965705662965775, 0.1634744554758072, 0.4523525536060333, -0.3757832944393158, 0.4548726975917816, -0.599041223526001, 0.07385692000389099, -0.4363863170146942, 0.29842808842658997, -0.3655802309513092, 0.09174377471208572, -0.32027727365493774, 0.11821815371513367, 0.006861484609544277, -0.1553696244955063, 0.0694686695933342, 0.15449534356594086, 0.17508180439472198, 0.22153940796852112, 0.24972018599510193, 0.21476325392723083, -0.383373886346817, -0.7093446850776672, -0.5496765971183777, 0.3112543821334839, 0.14355042576789856, -0.2916342616081238, -0.08828029036521912, 0.2818509340286255, 0.009557662531733513, 0.011790845543146133, -0.03469852730631828, -0.2392287403345108, -0.08908216655254364, 0.06354375928640366 ]
Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-renewal, pluripotency, and somatic cell reprogramming. However, limited information is available on Oct4-associated protein complexes and their intrinsic protein-protein interactions that dictate Oct4's critical regulatory activities. Here we employed an improved affinity purification approach combined with mass spectrometry to purify Oct4 protein complexes in mouse embryonic stem cells (mESCs), and discovered many novel Oct4 partners important for self-renewal and pluripotency of mESCs. Notably, we found that Oct4 is associated with multiple chromatin-modifying complexes with documented as well as newly proved functional significance in stem cell maintenance and somatic cell reprogramming. Our study establishes a solid biochemical basis for genetic and epigenetic regulation of stem cell pluripotency and provides a framework for exploring alternative factor-based reprogramming strategies.
[ 0.002259773202240467, 0.010690458118915558, -0.004430755507200956, 0.015550002455711365, -0.009529989212751389, 0.0010410696268081665, 0.011957338079810143, 0.002015992533415556, -0.011285828426480293, -0.012553186155855656, -0.004194239620119333, 0.008813094347715378, 0.0013655440416187048, 0.005199989303946495, 0.018352124840021133, 0.02619931288063526, -0.014619812369346619, -0.010134710930287838, 0.007820069789886475, -0.001917120534926653, -0.015159585513174534, 0.0016862244810909033, 0.009803232736885548, -0.015488091856241226, -0.022974152117967606, -0.011000564321875572, 0.029119249433279037, 0.012917363084852695, -0.02043040469288826, -0.035993244498968124, 0.013585899025201797, 0.006827486213296652, 0.009411544539034367, 0.0065469262190163136, -0.0026102138217538595, -0.0190330408513546, -0.008848724886775017, 0.01619771309196949, 0.02724144607782364, -0.0054701208136975765, -0.003012478817254305, -0.014088420197367668, 0.005886578932404518, -0.010710900649428368, -0.008809415623545647, -0.01008481066673994, -0.006843794137239456, 0.007193064317107201, -0.0077011482790112495, 0.0071258703246712685, -0.016098305583000183, -0.018973028287291527, -0.010598691180348396, 0.017348775640130043, -0.005462896544486284, 0.0028335489332675934, 0.016456231474876404, -0.006846611388027668, 0.025391139090061188, -0.023142505437135696, 0.03135405480861664, -0.003381817601621151, 0.015300093218684196, -0.009861785918474197, 0.013911810703575611, -0.06695707887411118, 0.009698412381112576, 0.008566225878894329, -0.0017688155639916658, 0.002758581889793277, 0.012734337709844112, 0.004446664825081825, -0.023036476224660873, -0.014798150397837162, 0.014365916140377522, -0.031974680721759796, -0.010439428500831127, 0.018208054825663567, 0.001836963347159326, 0.006315537728369236, -0.03357139602303505, -0.017166487872600555, 0.010268693789839745, -0.005699356086552143, 0.031182385981082916, 0.016991494223475456, -0.004358183592557907, 0.0009654427412897348, -0.00722950603812933, -0.016515377908945084, 0.001677417429164052, 0.01820634864270687, 0.01346132718026638, -0.01931885816156864, 0.01316185761243105, -0.008298827335238457, -0.017988154664635658, -0.030831892043352127, -0.002959510311484337, 0.016202056780457497, -0.029211048036813736, 0.015274206176400185, 0.01522604189813137, -0.012980167753994465, 0.024333208799362183, 0.003097217995673418, 0.018990101292729378, 0.040232881903648376, 0.025974705815315247, 0.007942277938127518, -0.0012853543739765882, 0.010635986924171448, -0.0069591389037668705, 0.02965051308274269, -0.010369200259447098, 0.01123170554637909, -0.012980835512280464, 0.011567065492272377, 0.017894010990858078, -0.012609226629137993, -0.01009325496852398, 0.018435217440128326, 0.006301124580204487, -0.001596522517502308, 0.004952704533934593, -0.000007013790309429169, -0.0011202327441424131, 0.0012018864508718252, -0.016744311898946762, -0.008740323595702648, -0.007621205877512693, -0.005608817562460899, 0.0026104063726961613, 0.012670593336224556, 0.007241155952215195, -0.007733842357993126, -0.005961036309599876, -0.00014849472790956497, -0.0008139288984239101, -0.04384477436542511, 0.0012133135460317135, 0.01080118864774704, 0.007908233441412449, 0.016694653779268265, 0.01604306697845459, -0.0005553185474127531, -0.012553103268146515, -0.006994312629103661, -0.004946255590766668, -0.017621997743844986, 0.003880078438669443, -0.021547503769397736, -0.002862834371626377, -0.017924942076206207, 0.02794482372701168, 0.019001618027687073, -0.007878332398831844, -0.02840891107916832, 0.0120224729180336, -0.01081404834985733, -0.025429699569940567, 0.0003257610369473696, 0.033075571060180664, 0.008196797221899033, 0.0053937314078211784, 0.0017301003681495786, 0.004575682803988457, 0.001317497924901545, -0.008440831676125526, 0.006017354317009449, 0.0005832818569615483, 0.01960604451596737, -0.016177577897906303, 0.008351027965545654, 0.007060593459755182, -0.014256216585636139, -0.0005638208240270615, 0.006083455868065357, -0.009688708931207657, 0.06682078540325165, -0.010688098147511482, 0.021132532507181168, 0.008336810395121574, 0.011664638295769691, -0.01981291174888611, 0.006104717496782541, -0.011473570019006729, -0.010035531595349312, 0.010682988911867142, -0.02160952053964138, 0.009766129776835442, 0.0015086359344422817, -0.033060166984796524, 0.0013907609973102808, -0.00833847839385271, 0.003572280751541257, -0.010700157843530178, 0.007548639550805092, 0.012861570343375206, -0.018237613141536713, 0.006560778710991144, -0.027115540578961372, 0.011011051014065742, -0.01736586168408394, -0.03615719452500343, 0.004572250880300999, -0.008996994234621525, 0.004736144561320543, -0.014078496024012566, 0.019169677048921585, 0.03708085045218468, -0.027060288935899734, -0.013283852487802505, -0.017941778525710106, 0.00014687282964587212, -0.004017064347863197, 0.020216135308146477, -0.0008686170913279057, -0.010708183981478214, -0.010776384733617306, 0.0011178948916494846, -0.01249954104423523, 0.025812800973653793, -0.0044602565467357635, 0.01545075885951519, -0.0020579949487000704, -0.023639056831598282, 0.013281171210110188, -0.002334020333364606, 0.002995464950799942, 0.003943570423871279, -0.0170748233795166, -0.011317860335111618, -0.016665179282426834, 0.006531588267534971, -0.0017761056078597903, 0.011767793446779251, -0.022724054753780365, 0.0065692150965332985, -0.005070396699011326, 0.0017998241819441319, 0.0014726133085787296, 0.04205656424164772, -0.026360146701335907, -0.006799034774303436, -0.028690140694379807, -0.004205708391964436, 0.0006172528956085443, 0.01339750550687313, -0.006967789959162474, 0.007182305678725243, 0.023912087082862854, 0.01612926460802555, -0.0003381704445928335, 0.015538489446043968, 0.020925499498844147, -0.021457046270370483, 0.002711682114750147, 0.024200990796089172, -0.034150946885347366, 0.0072037577629089355, 0.010762939229607582, -0.00356832193210721, 0.02060748264193535, 0.0029517486691474915, -0.028406959027051926, 0.004400116391479969, 0.024228397756814957, 0.0021403224673122168, 0.0009144190698862076, 0.010756553150713444, -0.0024945393670350313, -0.0029812909197062254, -0.08146333694458008, -0.010783880949020386, 0.0036657110322266817, 0.04638979583978653, 0.009015463292598724, -0.027065427973866463, -0.016122156754136086, 0.001754274358972907, -0.0045319427736103535, 0.0256580151617527, -0.004567068535834551, -0.015436103567481041, -0.0066720666363835335, -0.028848428279161453, 0.004261191003024578, -0.002144696656614542, 0.010342523455619812, 0.006619178224354982, -0.006188449915498495, -0.030448073521256447, 0.011133931577205658, -0.01218327134847641, -0.034713637083768845, 0.017098750919103622, -0.03135496750473976, 0.02554786205291748, -0.0019694201182574034, -0.0070099253207445145, 0.0012352443300187588, 0.010252268053591251, -0.02474670670926571, 0.01355675794184208, 0.031398624181747437, -0.005012856796383858, 0.008869599550962448, 0.0029396263416856527, -0.01673327386379242, -0.06129007041454315, -0.01852492243051529, 0.02991461008787155, -0.0034218064974993467, 0.009629325941205025, -0.009881728328764439, -0.002692241920158267, 0.0018150133546441793, -0.0000450526422355324, 0.014307976700365543, 0.006485680118203163, 0.024334967136383057, 0.0138252517208457, -0.009039526805281639, -0.0052187698893249035, -0.015785519033670425, 0.01833229511976242, -0.01517566666007042, -0.021540440618991852, -0.018226061016321182, 0.01713576540350914, -0.009571864269673824, -0.011150581762194633, 0.003657291643321514, 0.026533417403697968, -0.011159074492752552, 0.013167514465749264, 0.014679358340799809, 0.009552008472383022, 0.015530136413872242, 0.0019115583272650838, -0.00833418220281601, 0.001367371529340744, 0.010836668312549591, 0.0030786721035838127, 0.010042646899819374, -0.003081290749832988, -0.007153628394007683, -0.017328910529613495, -0.015095500275492668, -0.014565111137926579, 0.03689251095056534, -0.029206208884716034, -0.01559410523623228, -0.011914377100765705, -0.0022335718385875225, 0.00034353137016296387, -0.023274816572666168, -0.042522575706243515, 0.0102614751085639, 0.026850175112485886, 0.003397830296307802, -0.01493763830512762, 0.015846632421016693, 0.027471477165818214, -0.005466449074447155, 0.008659211918711662, 0.0124592874199152, -0.021754367277026176, 0.006958844140172005, -0.004721030592918396, -0.0037073278799653053, 0.008950479328632355, -0.024960212409496307, 0.003489553229883313, -0.031713247299194336, -0.011788366362452507, -0.012486966326832771, 0.012162940576672554, -0.0149140739813447, 0.0033041383139789104, 0.02542424201965332, 0.0026776064187288284, -0.007097108755260706, -0.0035408339463174343, -0.00945264846086502, 0.00744287483394146, 0.014065803959965706, -0.004804985597729683, -0.01646384224295616, -0.0029517505317926407, 0.07227158546447754, 0.0023388750851154327, -0.006562151946127415, -0.022698761895298958, 0.011152196675539017, -0.026577947661280632, -0.01519593596458435, 0.021137172356247902, 0.01813584379851818, 0.016629787161946297, 0.011882873252034187, 0.025059208273887634, 0.003337349509820342, 0.0035893465392291546, -0.028792085126042366, 0.0003805742599070072, -0.05492018908262253, -0.014968270435929298, 0.005037517286837101, 0.0003364207223057747, -0.0065599908120930195, -0.014718234539031982, -0.009031993336975574, -0.0073177507147192955, 0.01390094868838787, -0.008846401236951351, 0.014146355912089348, -0.013954048976302147, -0.02564910426735878, 0.010630177333950996, 0.017624415457248688, -0.0055522979237139225, -0.011730954051017761, 0.02241956815123558, 0.030369319021701813, -0.005325719248503447, 0.020968366414308548, -0.009574557654559612, -0.012411263771355152, 0.0014149846974760294, 0.0032936346251517534, -0.01711023971438408, 0.010526343248784542, -0.0018436855170875788, 0.0007732450030744076, -0.02030351385474205, 0.027848782017827034, -0.009290038608014584, -0.007623988203704357, -0.016043923795223236, -0.01157071627676487, 0.013330724090337753, 0.015687942504882812, -0.026068586856126785, 0.030084513127803802, 0.007810212671756744, -0.0008646149653941393, -0.001313515123911202, -0.012720722705125809, -0.01930205523967743, -0.038952674716711044, 0.0047887591645121574, -0.0012167776003479958, -0.013661704026162624, 0.014479340985417366, -0.007691806182265282, 0.015416298061609268, -0.012107879854738712, 0.007191943004727364, 0.023364221677184105, 0.018252328038215637, -0.017850859090685844, -0.0293909702450037, -0.024132266640663147, -0.0199030339717865, -0.006245196796953678, 0.004480170086026192, 0.00018536346033215523, 0.05462857335805893, 0.005266737192869186, -0.0008795172907412052, 0.03296632319688797, 0.004942546132951975, -0.016791803762316704, -0.01439748890697956, -0.006572728510946035, 0.011638068594038486, -0.07433171570301056, -0.015143578872084618, -0.008312448859214783, -0.006458388641476631, -0.006335374899208546, 0.017314881086349487, -0.02296481281518936, -0.003852579742670059, 0.016068730503320694, -0.0003397194668650627, 0.008295495994389057, 0.007088790647685528, 0.0022986242547631264, 0.005562704987823963, 0.008742186240851879, -0.011869999580085278, -0.00040526362136006355, 0.008491677232086658, -0.009093279018998146, -0.004665802698582411, -0.022913172841072083, -0.017827844247221947, -0.024200009182095528, -0.0030016277451068163, -0.01317332498729229, -0.08111806213855743, 0.009247271344065666, 0.010280408896505833, -0.01231776550412178, 0.007792455144226551, -0.013339651748538017, 0.007220884785056114, 0.006487587932497263, 0.0035206489264965057, -0.011113405227661133, 0.014647332951426506, 0.009340756572782993, -0.021295256912708282, -0.018522009253501892, 0.010079728439450264, -0.00819108635187149, 0.010773640125989914, -0.02699296548962593, -0.002515439409762621, -0.003591239219531417, -0.006592255085706711, 0.025489911437034607, -0.005522662773728371, -0.0071722171269357204, -0.015505908988416195, -0.011822730302810669, -0.01363113522529602, 0.015849854797124863, 0.012955904006958008, 0.013784234412014484, -0.02593754604458809, -0.00821306835860014, -0.02862052246928215, -0.027094785124063492, 0.02019473910331726, -0.020592395216226578, 0.011416308581829071, -0.016994955018162727, -0.0380970761179924, -0.016749804839491844, -0.005997166037559509, 0.018198084086179733, -0.0031354182865470648, -0.009377559646964073, 0.027738772332668304, 0.0020846312399953604, 0.010509572923183441, -0.007521804887801409, 0.011231743730604649, -0.030275488272309303, 0.015781443566083908, -0.011975999921560287, -0.02382075786590576, 0.02145473286509514, -0.0121998880058527, 0.02352386899292469, -0.010118784382939339, -0.007641622330993414, -0.001927375327795744, 0.008750607259571552, 0.0021787702571600676, 0.0041804020293056965, 0.0007199861574918032, 0.07187898457050323, 0.005609389394521713, 0.005677844397723675, -0.012685943394899368, 0.020415298640727997, 0.005744999274611473, 0.031676143407821655, -0.018715936690568924, 0.0072240810841321945, -0.006462891586124897, 0.01477931160479784, -0.013822900131344795, 0.004827701020985842, 0.014545109122991562, 0.004006687086075544, 0.009433064609766006, -0.006616552360355854, -0.007310051470994949, -0.027930378913879395, 0.045152224600315094, 0.0025674731004983187, 0.000488445395603776, -0.010917365550994873, 0.014053378254175186, 0.02619791403412819, 0.0011888795997947454, -0.03611559420824051, 0.01755533739924431, 0.005275653209537268, -0.006731144152581692, -0.019704770296812057, -0.01842048391699791, 0.0002641050086822361, 0.004561460576951504, 0.013690396212041378, 0.0005821473896503448, 0.011903014965355396, 0.010773303918540478, -0.00508341658860445, 0.0037929778918623924, -0.005445306189358234, 0.016140447929501534, 0.00328285270370543, 0.011467565782368183, -0.004308950621634722, -0.002315475372597575, -0.0001948745921254158, -0.005134817212820053, 0.0037466518115252256, 0.01748051866889, 0.020188841968774796, 0.005877750925719738, -0.013494029641151428, 0.012747623026371002, 0.0004533646861091256, 0.02250165306031704, -0.01782406121492386, 0.007536490447819233, -0.006593259982764721, -0.0001714564859867096, -0.003553952556103468, -0.012871049344539642, 0.009635199792683125, 0.0012960722669959068, 0.017229855060577393, -0.0015821605920791626, -0.001123542431741953, -0.017313770949840546, 0.023387620225548744, 0.01611005701124668, -0.005825995933264494, 0.008016040548682213, 0.00617213686928153, 0.060471996665000916, 0.007999931462109089, 0.026467131450772285, 0.025087637826800346, -0.004091689828783274, 0.02217385359108448, 0.01153318677097559, -0.028065869584679604, 0.031088605523109436, -0.002876800484955311, 0.004137336276471615, -0.03622705861926079, 0.013028631918132305, 0.007296370342373848, 0.0067831664346158504, -0.0011606987100094557, 0.01700049825012684, 0.03886455297470093, 0.005981679540127516, 0.006404317915439606, 0.008088331669569016, 0.013531094416975975, 0.033713750541210175, 0.014770330861210823, 0.003533126087859273, -0.0002451860345900059, 0.01678779534995556, 0.018644016236066818, 0.026032432913780212, -0.015443907119333744, -0.011624988168478012, -0.03345221281051636, -0.013397732749581337, -0.021661076694726944, 0.029488317668437958, 0.012889869511127472, 0.008796783164143562, 0.018955912441015244, 0.01183128822594881, 0.006752962712198496, 0.02084212936460972, -0.009713368490338326, 0.004718552343547344, -0.014885320328176022, -0.019370732828974724, -0.03514531999826431, -0.010659505613148212, -0.005139299668371677, 0.013373350724577904, -0.026181114837527275, -0.006744004786014557, 0.005452798679471016, -0.025085754692554474, -0.010009309276938438, 0.016622435301542282, 0.03286583349108696, 0.016401764005422592, 0.013365330174565315, 0.012548636645078659, -0.009999281726777554, -0.005009936634451151, -0.018229670822620392, -0.008073916658759117, 0.01360621303319931, -0.0013559749349951744, -0.010251175612211227, 0.005180599167943001, 0.01920347288250923, -0.0017870197771117091, 0.002389549743384123, 0.011139729991555214, 0.006731114350259304, 0.008819622918963432, 0.001359766349196434, -0.0047905826941132545, 0.008171847090125084, -0.0015750452876091003, 0.012512433342635632, -0.005757349077612162, 0.00843359436839819, -0.004716112278401852, 0.004664037376642227, 0.034051939845085144, 0.015442104078829288, -0.03372189402580261, -0.017711210995912552, -0.009174318052828312, 0.017729001119732857, -0.008594258688390255, -0.00894397497177124, -0.01007680594921112, 0.007924900390207767, 0.005182920955121517, 0.00781356543302536, 0.019047996029257774, -0.023379672318696976, 0.00582809466868639, 0.007387299556285143, -0.006601213477551937, 0.006541037000715733, 0.011596396565437317, -0.00937255285680294, -0.0028262550476938486, -0.002316227648407221, -0.003884206060320139, 0.004708641208708286, 0.018150800839066505, -0.025365617126226425, -0.026224253699183464, 0.012636342085897923, -0.013551663607358932, 0.027937138453125954, -0.0019872644916176796, -0.00790896825492382, -0.0037899119779467583, -0.002104506129398942, -0.017415735870599747, -0.021290088072419167, -0.02497415989637375, 0.0012015715474262834, 0.015649408102035522, 0.0018584756180644035, 0.00402161106467247, 0.01377248764038086, -0.02756345085799694, 0.01501194853335619, 0.0049940613098442554, 0.012130447663366795, -0.020076245069503784 ]
[ -0.16881601512432098, -0.3304353356361389, 0.5455629229545593, 0.24407780170440674, 0.00932426005601883, -0.13271138072013855, 0.08510192483663559, -0.20396772027015686, -0.20297764241695404, 0.1383727341890335, -0.08088285475969315, 0.05494774505496025, -0.29244714975357056, 0.10150711983442307, 0.043912794440984726, 0.7116031050682068, 0.49585041403770447, 0.5823273062705994, -0.09307624399662018, -0.694494366645813, -0.23253729939460754, -0.07327180355787277, 0.5737987756729126, 0.1252964287996292, -0.09071438014507294, 0.037991512566804886, 0.16194725036621094, -0.6267584562301636, 0.4368601441383362, -0.24135905504226685, -0.48811838030815125, 0.51126629114151, 0.09041765332221985, -0.10596004873514175, -0.2609860599040985, -0.27307233214378357, -0.7728309035301208, -0.16109247505664825, 0.02421090193092823, 0.14931419491767883, 0.018362924456596375, -0.6787558197975159, 0.0029253019019961357, 0.37603244185447693, -0.092569999396801, -0.5263896584510803, -1.407482385635376, 0.9092471599578857, 0.058938317000865936, 0.107347771525383, -0.4823065996170044, 0.3926287591457367, -0.0039038427639752626, -0.06849981844425201, 0.6414124965667725, -0.1596900224685669, -1.0870215892791748, -0.27281004190444946, 0.7654098868370056, -0.459392249584198, -0.3881279528141022, -0.10282086580991745, -0.3092905282974243, 0.09940024465322495, -0.07988013327121735, 0.5048096179962158, 0.17517682909965515, -0.28771212697029114, -0.7511998414993286, -0.2645210325717926, 0.18500825762748718, -0.08926764130592346, 0.0021340427920222282, 0.09754741936922073, 0.09609086066484451, -0.3432425856590271, -0.4364936947822571, -0.012092160992324352, 0.2050209641456604, 0.3163679540157318, -0.05202684924006462, 0.2761707603931427, 0.2756447494029999, 0.22301702201366425, 0.644904375076294, 0.39814165234565735, -0.48994043469429016, 0.512481689453125, -0.2291119247674942, -0.3480440676212311, -0.1726841777563095, 0.08886680752038956, 0.3474840521812439, 0.6344778537750244, 0.3238794207572937, 0.5958933234214783, -0.28686296939849854, -0.15239834785461426, -0.18914684653282166, 0.272071897983551, -0.04216836765408516, 0.2074684202671051, -0.19332554936408997, -0.5853813886642456, -0.7046118378639221, -0.38176244497299194, -0.2809133529663086, -0.5403053164482117, -0.15719687938690186, 0.5331143140792847, -0.8156270980834961, -0.015760138630867004, -0.5249112248420715, -0.12407692521810532, 0.2922253906726837, 0.07425964623689651, 0.3327339291572571, -0.634706974029541, 0.2729485332965851, 0.42057105898857117, -0.2979128956794739, 1.4790451526641846, -0.0072511546313762665, 0.5171919465065002, -0.16025979816913605, -0.044346101582050323, 0.0894106775522232, 0.01155436784029007, -0.17982454597949982, 0.23383159935474396, 0.24093805253505707, 0.9774126410484314, -0.3695824146270752, -0.16994421184062958, -0.24105921387672424, -0.1294516623020172, -0.13560952246189117, 0.24272283911705017, 0.1918618083000183, 0.175335094332695, -0.8689075112342834, -0.6127448081970215, -0.12289823591709137, 0.23394298553466797, -0.14019463956356049, 0.19221509993076324, -0.681699812412262, 0.15938471257686615, -0.1562250852584839, -0.15477648377418518, 0.16399617493152618, -0.3023720979690552, -0.7054165005683899, -0.3922148644924164, -0.1581776887178421, 0.47804173827171326, 0.1715010106563568, -0.294769823551178, 0.24087336659431458, 0.167632058262825, 0.014667978510260582, -0.1612199991941452, -0.441261351108551, 0.004700890276581049, 0.30370181798934937, -0.30886438488960266, 0.45525315403938293, 0.2374245673418045, 0.04354863986372948, 0.17818282544612885, -0.5803167819976807, -0.28783220052719116, 0.11345407366752625, -0.44433531165122986, 0.1911255270242691, -0.4413476586341858, 0.029962744563817978, -0.17871344089508057, 0.033170949667692184, 0.2861315906047821, -0.9924708008766174, -0.24892525374889374, -0.2609187960624695, -0.9605034589767456, 0.40327033400535583, 0.7517300248146057, 0.5477455854415894, -0.1063513532280922, 0.11184549331665039, 0.18431706726551056, -0.010651104152202606, 0.07154043763875961, 0.4815501570701599, -0.519903302192688, 1.5664750337600708, -0.1343880295753479, 0.2308109849691391, 1.2875454425811768, -0.050407785922288895, 0.12679634988307953, -0.22835321724414825, -0.09472288936376572, 0.7524324059486389, -0.1539020538330078, -0.6170654892921448, 0.15453043580055237, 0.030950171872973442, -0.05988982319831848, -0.24904541671276093, -0.330564022064209, 0.051894254982471466, -0.401442289352417, 0.3099023997783661, -0.32339298725128174, 0.20924483239650726, -0.5297898054122925, 0.10613466799259186, -0.3285408914089203, -0.7515439391136169, 0.32608145475387573, 0.7688039541244507, -0.643301248550415, 0.4450833797454834, 1.183628797531128, -0.42337217926979065, 0.7763148546218872, 0.6004297733306885, 0.14635536074638367, 0.7134595513343811, -0.03270316123962402, -0.0625331774353981, -0.8101348280906677, -0.19644895195960999, -0.23896470665931702, -0.1667110174894333, -0.015956861898303032, 0.40940630435943604, 0.05417930707335472, -0.026077421382069588, -0.20766711235046387, 0.12397242337465286, 0.6786352396011353, -0.39939555525779724, 0.07461638748645782, 0.1695196032524109, -0.34009766578674316, -0.09206247329711914, 0.2757015824317932, -0.46241697669029236, -0.019354594871401787, 0.15769684314727783, -0.09896381199359894, 0.5163213014602661, -0.7281488180160522, 0.6524842381477356, 0.17615844309329987, -0.04848906770348549, -0.19476838409900665, 0.08884307742118835, -0.15054069459438324, -0.282806932926178, -0.24782341718673706, -0.17130924761295319, -0.30140969157218933, 0.4292666018009186, -0.006190952379256487, -0.2593381404876709, -0.4201448857784271, 1.3590879440307617, 0.5365868806838989, 0.43584027886390686, -0.33702388405799866, -0.5856449007987976, -0.21729427576065063, 0.03559976443648338, -0.3800535798072815, -0.45380648970603943, 0.381430059671402, -0.3045139014720917, -0.4902361333370209, -0.32353895902633667, 0.13690035045146942, 0.39418643712997437, -0.329193115234375, -0.2895512580871582, 0.4640549123287201, -0.2271568477153778, -0.12903988361358643, -0.8858720064163208, -0.8538230061531067, 0.2676965892314911, -0.46149420738220215, -0.09842032194137573, 0.2381078451871872, 0.25362861156463623, 0.5714922547340393, -0.14473119378089905, 0.49068593978881836, 0.5901045799255371, 0.3419932723045349, 0.10979342460632324, 0.13318540155887604, -0.32298359274864197, -0.38715556263923645, -0.07965020835399628, -0.1573564112186432, -0.32421091198921204, 0.690477192401886, -5.645888328552246, -0.0474076047539711, -0.5551667213439941, -0.02958238124847412, -0.06051333248615265, -0.1318676620721817, 0.8146575689315796, 0.29306554794311523, 0.6681271195411682, 0.2212170511484146, 0.15490783751010895, 0.28935039043426514, -0.46898213028907776, 0.28956368565559387, -0.027365703135728836, 0.28903165459632874, 0.053386662155389786, -0.14218279719352722, 0.7621159553527832, 0.24735718965530396, 0.42313626408576965, 0.09452278167009354, -0.07679644972085953, 0.12430629879236221, -0.010080047883093357, -0.3107709586620331, -0.8313956260681152, -0.2019115537405014, -0.2639719545841217, -0.33966052532196045, -0.13032354414463043, -0.4016707241535187, -0.04199698567390442, -0.7316160202026367, -0.022722216323018074, -0.1900618076324463, 0.3449026048183441, 0.2221524566411972, -0.013922072015702724, -0.4740939140319824, 0.3671245276927948, 0.07548324018716812, 0.008646364323794842, 0.14953899383544922, 0.11290829628705978, -0.13315178453922272, -0.12099164724349976, 0.24656455218791962, -0.22465397417545319, 0.7116150259971619, -0.18041114509105682, -0.5628044009208679, 0.8002703785896301, 0.34280747175216675, 0.5880324244499207, -0.2587180435657501, -0.34102165699005127, 0.18531285226345062, -0.5037716627120972, 0.002601375337690115, -0.47035568952560425, -0.23321221768856049, -0.046585191041231155, -0.6423221230506897, 0.09678664803504944, 0.6702486276626587, -0.8922883868217468, -0.4100279211997986, 0.46917128562927246, -0.20165005326271057, -0.41982585191726685, 0.7279872894287109, 0.17253299057483673, -0.7342777848243713, 0.6027095317840576, -0.0001988316362258047, 0.20097018778324127, 0.09425170719623566, -0.469110369682312, 0.13112612068653107, -0.8219306468963623, -0.12708190083503723, -0.0994487926363945, -0.029930150136351585, 0.34744569659233093, -0.00795793067663908, 0.059127986431121826, -0.14267893135547638, -0.06544487923383713, 0.5680514574050903, 0.31913959980010986, -0.38518819212913513, 0.2346564531326294, 0.6815776228904724, 0.14266085624694824, 0.018250582739710808, 0.15632380545139313, 0.2399691790342331, 0.30359408259391785, -0.047524772584438324, 0.7062521576881409, 0.33990031480789185, -0.35882094502449036, -0.556044340133667, -0.1703767478466034, 0.035482991486787796, -0.20651987195014954, 0.08080077916383743, 0.5843757390975952, -0.47059911489486694, 0.15187974274158478, -0.08424397557973862, -0.6221466064453125, -0.4687750041484833, 0.9229023456573486, -0.15019327402114868, 0.11603520810604095, -0.10352925211191177, 0.6127246618270874, -0.3490089476108551, 0.0625893771648407, 0.45242840051651, -0.24819567799568176, 0.6727067232131958, -0.47478538751602173, -0.2763077914714813, 0.15117093920707703, 0.3326684236526489, -0.7370548844337463, -0.09907121956348419, 0.225127711892128, 0.3992258608341217, -0.13156424462795258, 0.03417453542351723, 0.08973581343889236, -0.23922817409038544, 0.096276193857193, 0.3005625307559967, -0.28540492057800293, -0.4516933560371399, 0.5402839183807373, -0.18229566514492035, -0.23422007262706757, 0.16990222036838531, -0.0005054814973846078, 0.2574456036090851, -0.035191625356674194, 0.5624454021453857, -0.5441134572029114, 0.13840351998806, 0.13121317327022552, -0.48343318700790405, 0.23028430342674255, 0.22038690745830536, 0.2018675059080124, 0.4362682104110718, 0.23005354404449463, 0.054941341280937195, 0.7943778038024902, -0.3807939291000366, 0.25413379073143005, 0.5274686813354492, -0.7128279805183411, 0.017012275755405426, -0.01987287402153015, 0.06994888931512833, -0.10786306858062744, -0.5608502626419067, -0.04424266144633293, 0.5204753279685974, -0.4313894510269165, 0.2852202355861664, -0.15465609729290009, -0.3426096439361572, 0.1999354362487793, 0.015316891483962536, -0.2891726791858673, 0.09254734963178635, 0.08639263361692429, 0.24998806416988373, 0.2484654039144516, -0.5966724157333374, -0.20693859457969666, 0.45447635650634766, 0.6209971308708191, 0.24833904206752777, 0.09501323103904724, -0.4277578890323639, -0.12983541190624237, -0.3188149631023407, 0.17716051638126373, 0.22712598741054535, 0.27315935492515564, -0.040356848388910294, 0.09043939411640167, 0.1302952915430069, 0.4341857135295868, 0.35967791080474854, -0.04111297428607941, -0.6314806938171387, -0.25504109263420105, 0.37804850935935974, -0.15130288898944855, 0.33137887716293335, 0.3906514346599579, 0.1438721865415573, -0.1695166826248169, 0.1616719365119934, 0.06273700296878815, -0.11209047585725784, -0.07084658741950989, -0.5273535251617432, 0.5529815554618835, -0.09973128139972687, 0.10211367160081863, -0.05699114874005318, -0.1804451197385788, -0.21895620226860046, -0.5179101824760437, 0.25698772072792053, -0.18247312307357788, -0.06829556077718735, 0.021962013095617294, -0.3845404088497162, -0.544647216796875, -0.23948515951633453, 0.27374371886253357, -0.776206910610199, 0.3543386161327362, 0.2783234417438507, -0.07191801816225052, -0.5523806214332581, 0.3149961829185486, -0.020398281514644623, -0.8047157526016235, -0.9506614208221436, -0.3237553834915161, 0.5076883435249329, -0.119488924741745, 0.7710539698600769, 0.2341025173664093, 0.31915152072906494, -0.30614346265792847, -0.3176827132701874, -0.2509712874889374, 0.1688409000635147, 0.19841371476650238, -0.702972412109375, -0.7168641090393066, -0.03203604370355606, 0.3939933478832245, -0.14312154054641724, 0.18946394324302673, 0.16850672662258148, 1.3081730604171753, -0.016507793217897415, 0.3067913055419922, -0.25046613812446594, -0.25847214460372925, -0.03146330267190933, -0.310725599527359, 0.0013998572248965502, -0.18380534648895264, -0.22030556201934814, 0.10230778902769089, 0.21725034713745117, 0.21803626418113708, -1.0728373527526855, 0.6755655407905579, -0.22675959765911102, -0.39283233880996704, -0.194165900349617, 0.6122878789901733, 0.5031912326812744, -0.18673866987228394, 0.21417708694934845, -0.2601439654827118, 0.1753714382648468, -0.13523034751415253, -0.10891798138618469, -0.18176236748695374, -0.31368425488471985, 0.4500334560871124, -0.31493064761161804, 0.47625213861465454, -0.29106488823890686, -0.22087477147579193, -0.34300774335861206, 0.4610618054866791, 0.3763622045516968, -0.5205605626106262, 0.039723239839076996, -1.039303183555603, -0.5149633288383484, 0.16325761377811432, 0.09840450435876846, 0.09631025046110153, 0.15425516664981842, -0.4070328176021576, 0.2435927540063858, -0.6039275527000427, 0.7959640622138977, 0.6276403069496155, -0.6463205218315125, -0.542881429195404, -0.055715881288051605, 0.26337239146232605, 0.11643145233392715, -0.6003312468528748, 0.3023824691772461, 0.07933641970157623, -0.08666245639324188, 0.5964645743370056, -0.04136449471116066, -0.635297417640686, 0.2856919467449188, -0.23850688338279724, -0.1801033467054367, 0.35611066222190857, 0.26707133650779724, 0.408306360244751, 0.7888920903205872, 0.6806058883666992, -0.04003928229212761, -0.5251379609107971, 0.6858235597610474, -0.01445094496011734, -0.12406320124864578, -0.12563705444335938, 0.4673193395137787, 0.35186219215393066, 0.05504896864295006, -0.2447456419467926, 1.0116451978683472, 0.5015891194343567, -0.07182354480028152, 0.2661743760108948, -0.4090190529823303, -0.07572616636753082, 0.08932437002658844, 0.33031946420669556, 1.00112783908844, -0.25962406396865845, -0.11854938417673111, 0.23446743190288544, 0.49338674545288086, 0.14544741809368134, -0.02884228713810444, -0.38381725549697876, 0.3626933991909027, 0.3519558310508728, -0.389393150806427, -0.5703762173652649, 0.043105896562337875, -0.6399678587913513, 0.014893748797476292, 0.30204489827156067, -0.41935813426971436, 0.3661953806877136, 0.4230639934539795, -0.4842844307422638, 0.1485002189874649, -0.01323891244828701, 0.8084867596626282, -0.389313280582428, -0.031294018030166626, 1.0350935459136963, 0.23637273907661438, 0.26755470037460327, -0.18634018301963806, -0.28664156794548035, 0.05579306557774544, -0.20037218928337097, 0.10636605322360992, -0.16113992035388947, -0.4552287459373474, 0.1270923614501953, -0.4479048550128937, -0.10856109857559204, 0.4059799015522003, -0.18690179288387299, 0.2964284420013428, -0.08003728836774826, -0.7077971696853638, -0.23686407506465912, -0.32773980498313904, -0.21363867819309235, -0.22976574301719666, 0.20494134724140167, -0.060956064611673355, -0.09602846950292587, -0.7250996828079224, 0.3890383243560791, 0.2465360015630722, 0.28579992055892944, -0.08225284516811371, -0.10076829046010971, 0.6794891357421875, 0.6423035860061646, 0.6191574335098267, 0.2430678755044937, 0.10820285975933075, -0.1561146229505539, 0.29364967346191406, -0.6318598389625549, 0.629500150680542, -0.4350064992904663, -0.8622219562530518, -0.39945411682128906, 0.08354916423559189, 1.0944560766220093, 1.0403413772583008, -0.4274643659591675, -0.28901270031929016, 0.1564638316631317, 0.6371860504150391, 0.4815484881401062, -0.7879219651222229, -0.14531417191028595, -0.47322091460227966, -0.3137533366680145, 0.29468944668769836, 0.9340757131576538, 0.39118075370788574, -0.4751434028148651, -0.1852007657289505, 0.6709167957305908, -0.01570499874651432, -0.48253241181373596, -0.004344396758824587, -0.2627045214176178, -0.29252010583877563, -0.5300775766372681, 0.6376931071281433, -0.5318467617034912, 0.6065654158592224, -0.5970374941825867, -0.03829212859272957, 0.02190522663295269, -0.019751494750380516, 0.14171381294727325, 0.2707056403160095, -0.5429481863975525, -0.37888652086257935, 0.12476103752851486, 0.32801440358161926, -0.7126719355583191, -0.9841002821922302, -0.47651076316833496, -0.15269453823566437, 0.2443748414516449, -0.18725986778736115, 0.08062606304883957, -0.08202335983514786, -0.06642842292785645, -0.14023888111114502, 0.3121758699417114, -0.41984468698501587, -0.0479053370654583, 0.1350117027759552 ]
The Tet family of enzymes (Tet1/2/3) converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Mouse embryonic stem cells (mESCs) highly express Tet1 and have an elevated level of 5hmC. Tet1 has been implicated in ESC maintenance and lineage specification in vitro but its precise function in development is not well defined. To establish the role of Tet1 in pluripotency and development, we have generated Tet1 mutant mESCs and mice. Tet1(-/-) ESCs have reduced levels of 5hmC and subtle changes in global gene expression, and are pluripotent and support development of live-born mice in tetraploid complementation assay, but display skewed differentiation toward trophectoderm in vitro. Tet1 mutant mice are viable, fertile, and grossly normal, though some mutant mice have a slightly smaller body size at birth. Our data suggest that Tet1 loss leading to a partial reduction in 5hmC levels does not affect pluripotency in ESCs and is compatible with embryonic and postnatal development.
[ -0.00789782777428627, 0.0033484979066997766, -0.010973060503602028, 0.007908513769507408, 0.01562998816370964, -0.003226684406399727, 0.010131018236279488, -0.01664363406598568, -0.011163432151079178, -0.020517395809292793, -0.004761632531881332, 0.0023336042650043964, -0.00743155088275671, 0.009032060392200947, 0.00943783763796091, 0.025403261184692383, -0.023951951414346695, -0.019304605200886726, 0.01305778231471777, 0.008076505735516548, -0.006077625323086977, 0.004818327259272337, 0.008508683182299137, -0.015308203175663948, 0.006354962475597858, 0.011250518262386322, 0.011041202582418919, -0.003829915774986148, -0.0009603679645806551, -0.042857419699430466, 0.006447808351367712, -0.007802901789546013, 0.004405546467751265, -0.005367820616811514, -0.008158874697983265, 0.0009653945453464985, -0.006658208090811968, 0.01830204203724861, 0.037062935531139374, -0.005297127179801464, -0.00840731430798769, -0.004931418225169182, 0.0051477705128490925, 0.00665863836184144, -0.00428620632737875, 0.005459538660943508, -0.004167086444795132, -0.00495689082890749, 0.014217469841241837, 0.001317818183451891, -0.0143051128834486, 0.004421709571033716, -0.012863187119364738, 0.0008483012206852436, -0.004915617406368256, -0.00325498403981328, 0.014403006061911583, -0.02112741395831108, -0.0013251279015094042, -0.011763829737901688, 0.027564212679862976, -0.015381150878965855, 0.019089587032794952, 0.029520023614168167, -0.003337893635034561, -0.06714466959238052, 0.0036368402652442455, 0.01599196530878544, -0.005450361408293247, 0.008039443753659725, 0.003129829652607441, 0.006918024271726608, -0.004940328188240528, 0.002159961499273777, -0.016461443156003952, -0.024326641112565994, -0.02380882203578949, 0.032028354704380035, 0.03334943950176239, 0.015089811757206917, 0.008740049786865711, -0.022406063973903656, 0.015819773077964783, 0.00221647578291595, -0.013163554482161999, 0.005658749025315046, -0.023189453408122063, 0.010533664375543594, 0.004828448873013258, -0.01830919273197651, -0.011999649927020073, 0.02009481191635132, -0.0009547860827296972, -0.006916537880897522, -0.0081976018846035, 0.015602260828018188, -0.00662567000836134, -0.027226798236370087, 0.027910251170396805, 0.018647147342562675, -0.01966344565153122, -0.008392615243792534, 0.020918067544698715, 0.02893959917128086, -0.012531277723610401, 0.009185321629047394, 0.0010830801911652088, 0.005423988215625286, 0.025842223316431046, 0.0074563040398061275, -0.005154692102223635, -0.005061065778136253, -0.009052003733813763, 0.02236931398510933, 0.003360562026500702, -0.010778645053505898, -0.007185560185462236, 0.012667681090533733, 0.01532864198088646, -0.044319309294223785, -0.014390774071216583, 0.009416598826646805, -0.011910045519471169, -0.031693875789642334, 0.008966872468590736, -0.01590663753449917, -0.013345356099307537, 0.004062633495777845, -0.010703826323151588, -0.010333741083741188, -0.007654738612473011, -0.0003122324123978615, 0.01589745283126831, -0.010976850055158138, 0.01219970267266035, -0.005353869870305061, -0.009112882427871227, 0.009713217616081238, -0.0012426016619428992, -0.018408091738820076, -0.006408767309039831, 0.011369911953806877, 0.012461589649319649, 0.008962465450167656, 0.013736125081777573, -0.002695716917514801, -0.020704975351691246, 0.005802524276077747, 0.011976521462202072, -0.036884553730487823, 0.010736447758972645, -0.02960711531341076, -0.011015983298420906, -0.017909670248627663, -0.002662020269781351, 0.03358942270278931, -0.011338505893945694, -0.013101588934659958, 0.011212432757019997, 0.02565952017903328, -0.03810587152838707, -0.016143353655934334, 0.012423921376466751, 0.008164295926690102, -0.013118075206875801, 0.003065173514187336, -0.030164986848831177, -0.013564525172114372, -0.008796595968306065, 0.005780067294836044, 0.0012253024615347385, -0.03268463909626007, 0.012851664796471596, 0.002649797825142741, -0.025505375117063522, -0.004037439823150635, 0.0001329001970589161, 0.006635298021137714, -0.02183152735233307, 0.06687265634536743, -0.014383718371391296, 0.04058288037776947, 0.012668204493820667, 0.030031245201826096, 0.0068635959178209305, -0.008993079885840416, 0.023196417838335037, -0.00463505694642663, -0.029359988868236542, 0.0031203797552734613, 0.005085320211946964, 0.010125439614057541, -0.011487742885947227, -0.004983002319931984, -0.023840606212615967, 0.0028093894943594933, -0.0017163802403956652, 0.007152849808335304, -0.002434025052934885, -0.02149365469813347, 0.007243809290230274, 0.01040002889931202, 0.006013593636453152, 0.005652851425111294, -0.0031520118936896324, 0.01163626927882433, 0.0296647772192955, -0.018503781408071518, -0.005898116156458855, 0.0072534773498773575, 0.027997855097055435, -0.005233129486441612, -0.00803112518042326, -0.012437302619218826, -0.0037382966838777065, 0.011163778603076935, -0.0056173307821154594, 0.0001382497139275074, -0.0025084891822189093, -0.010795824229717255, -0.0062951585277915, 0.002240318339318037, 0.021140122786164284, 0.0008780192583799362, 0.010060394182801247, -0.013468298129737377, 0.0006174022564664483, 0.008845757693052292, -0.007908644154667854, 0.0035231360234320164, -0.010504224337637424, -0.026480184867978096, -0.012183248065412045, 0.025129880756139755, -0.015270776115357876, 0.00005880091339349747, 0.011535536497831345, 0.00007672805804759264, 0.018364980816841125, -0.010200079530477524, -0.016002638265490532, 0.003826241474598646, 0.020970933139324188, 0.007929960265755653, -0.006220310926437378, -0.010628607124090195, 0.02677900716662407, 0.0035553963389247656, 0.002490213606506586, -0.02389843761920929, 0.008639037609100342, -0.005729881580919027, 0.01874644123017788, -0.011073878966271877, -0.009859966114163399, -0.01606796309351921, -0.012820204719901085, 0.014465948566794395, 0.02380775660276413, 0.005827703513205051, -0.0010975142940878868, 0.00815015658736229, 0.002579920459538698, 0.03397779166698456, 0.0032074633054435253, -0.0060148159973323345, 0.02303329110145569, 0.03289422020316124, 0.019825100898742676, 0.0026597375981509686, 0.010872473940253258, -0.004863766487687826, 0.002822374226525426, -0.08184487372636795, -0.004757669288665056, 0.007950863800942898, 0.007510697469115257, 0.005169127136468887, 0.014286566525697708, -0.032343264669179916, -0.007302431855350733, -0.00832163542509079, 0.00007839733734726906, -0.0009637037292122841, -0.017850780859589577, -0.00808575190603733, -0.04936066269874573, -0.01913084276020527, -0.002761431038379669, 0.007447905372828245, 0.008193864487111568, -0.007474035024642944, -0.011663844808936119, 0.016586434096097946, -0.024419058114290237, -0.02573779784142971, 0.021152593195438385, -0.019215449690818787, 0.011822512373328209, 0.0014063778799027205, -0.009027308784425259, -0.0062194159254431725, 0.004234092775732279, -0.03073420189321041, -0.022269822657108307, 0.04269654303789139, -0.00841207429766655, 0.01239222101867199, 0.014857495203614235, -0.0022128927521407604, -0.004786823410540819, 0.001274139853194356, 0.04405275732278824, -0.027158835902810097, 0.02122356928884983, 0.000619781669229269, -0.001557492301799357, 0.007574205286800861, 0.010966163128614426, 0.04086879640817642, -0.009413927793502808, 0.019442766904830933, -0.0058968509547412395, 0.006874624639749527, 0.0003558620810508728, -0.015386362560093403, 0.019923029467463493, -0.007941248826682568, -0.03730820119380951, -0.020214766263961792, -0.010787184350192547, -0.015499528497457504, -0.002540217712521553, 0.0004108562134206295, -0.00004959572106599808, -0.0012341509573161602, 0.02113090641796589, 0.0037432783283293247, 0.03306170552968979, 0.005967242643237114, -0.005255145952105522, -0.026534024626016617, 0.003656349377706647, 0.007671593688428402, 0.0044740308076143265, -0.00797734409570694, -0.005683088209480047, -0.026585653424263, -0.013721048831939697, -0.011842954903841019, 0.0024228054098784924, 0.021502666175365448, -0.009993746876716614, -0.0180145725607872, -0.015265144407749176, -0.03282912075519562, -0.01256626471877098, -0.013257910497486591, -0.032752931118011475, 0.005466820206493139, 0.05460188165307045, 0.00805327296257019, -0.009886093437671661, -0.0026662794407457113, 0.0009545981884002686, 0.01251087337732315, 0.010630171746015549, -0.014121457934379578, -0.029986273497343063, -0.005830025300383568, 0.00024216179735958576, 0.017764873802661896, 0.006270774640142918, -0.000023747794330120087, 0.0008097009267657995, -0.004302126821130514, -0.004667335189878941, 0.0026180159766227007, 0.010504832491278648, -0.01601349376142025, 0.019742751494050026, 0.0009498661383986473, -0.0037038219161331654, 0.017816174775362015, -0.0026780457701534033, -0.007961968891322613, 0.02530086040496826, 0.00652835238724947, -0.002460627583786845, -0.01619640365242958, -0.010813574306666851, 0.07272114604711533, -0.005405997857451439, 0.0029273023828864098, -0.02041497454047203, 0.012458186596632004, -0.030004872009158134, -0.009715761989355087, 0.015412876382470131, -0.016182322055101395, 0.026290372014045715, 0.011581795290112495, -0.021495508030056953, 0.01944645121693611, -0.017259269952774048, -0.025796232745051384, 0.008786720223724842, -0.026759766042232513, -0.013785515911877155, -0.008458929136395454, 0.006949643138796091, 0.0218953937292099, -0.008974268101155758, -0.005772074684500694, -0.0092655373737216, 0.012205795384943485, -0.021526772528886795, 0.020026374608278275, -0.010142441838979721, -0.00820248294621706, 0.012007120065391064, 0.015820840373635292, -0.002148212166503072, -0.009362391196191311, -0.007136490195989609, 0.025757476687431335, 0.016961976885795593, 0.010739341378211975, -0.016406679525971413, -0.02014259807765484, -0.0046357265673577785, -0.01367875561118126, -0.013568587601184845, -0.008903885260224342, 0.005269109271466732, 0.010062716901302338, -0.011289369314908981, 0.06556352227926254, -0.010480059310793877, 0.0004451093263924122, -0.013571732677519321, -0.015234735794365406, 0.006037130951881409, 0.013461642898619175, 0.004194812849164009, 0.01563665270805359, 0.0028827739879488945, 0.006268903613090515, -0.0016976455226540565, -0.011219912208616734, -0.014874082058668137, -0.01149335689842701, -0.012374558486044407, -0.0007857657037675381, -0.030182957649230957, 0.01206919178366661, -0.017038553953170776, -0.023505255579948425, 0.008550895377993584, 0.008131923153996468, -0.00795045681297779, 0.02007308229804039, -0.022450722754001617, 0.004145399201661348, -0.00948513112962246, -0.02117069624364376, 0.03794940188527107, 0.007350912783294916, 0.01524471677839756, 0.02643091231584549, 0.009226815775036812, -0.01382917445152998, 0.005117786582559347, -0.0171572957187891, -0.005271734669804573, 0.018628660589456558, 0.024144906550645828, 0.008342898450791836, -0.07506849616765976, -0.01002618856728077, 0.018618538975715637, -0.0022093665320426226, -0.012491140514612198, -0.0108348298817873, -0.025418143719434738, 0.02418709173798561, 0.028602423146367073, -0.00003054458647966385, 0.024279072880744934, -0.009590933099389076, 0.004110085777938366, 0.003036536742001772, 0.009002064354717731, -0.0018081695307046175, -0.02097473293542862, -0.010180827230215073, -0.008341846987605095, -0.010846665129065514, -0.02171919494867325, -0.005380152724683285, -0.02665826678276062, -0.003056052140891552, -0.0038865453097969294, -0.08167238533496857, 0.01915774680674076, -0.0033552744425833225, 0.003989956341683865, -0.0012974162818863988, -0.012654068879783154, 0.0016775606200098991, -0.022968020290136337, -0.007729942910373211, -0.01250691432505846, 0.02001713216304779, -0.004865123424679041, 0.001297647599130869, -0.025448843836784363, 0.021017413586378098, -0.0080477986484766, -0.0018702067900449038, 0.01408756896853447, 0.002676093950867653, 0.007729415316134691, -0.018239151686429977, -0.020258933305740356, -0.008385123685002327, -0.009719775058329105, -0.004532967694103718, -0.010769147425889969, -0.005885745398700237, 0.012833129614591599, -0.0013102376833558083, 0.023733437061309814, -0.011292964220046997, 0.00910117756575346, -0.01421015989035368, -0.010462738573551178, -0.008102411404252052, -0.02395317144691944, 0.0008900919929146767, -0.008235087618231773, -0.016240037977695465, -0.007925793528556824, -0.0056905122473835945, 0.011349743232131004, 0.00034139142371714115, -0.00029660342261195183, 0.02091486006975174, -0.005159024149179459, 0.0055963220074772835, -0.01072065718472004, 0.00852698553353548, -0.014695468358695507, 0.005093789659440517, 0.003636234439909458, -0.021041076630353928, 0.021982714533805847, -0.012564136646687984, 0.016776353120803833, -0.001990311546251178, 0.008968768641352654, 0.009008888155221939, 0.011176192201673985, -0.002403321908786893, 0.008121002465486526, -0.003876354079693556, 0.07232867181301117, -0.010178147815167904, 0.015994291752576828, -0.00905768945813179, -0.006643689237535, 0.004870287142693996, -0.0010336325503885746, -0.025525342673063278, 0.005914004053920507, -0.013110604137182236, 0.002511104568839073, -0.0031953167635947466, -0.007765642367303371, 0.012554401531815529, -0.01627180352807045, -0.0007828599773347378, 0.00563898216933012, 0.01926458813250065, 0.0030550938099622726, 0.032573193311691284, -0.010425706394016743, -0.022597115486860275, -0.019749075174331665, -0.0021423688158392906, 0.009975573979318142, -0.009074793197214603, -0.03016866184771061, -0.005722888745367527, 0.0016491729766130447, -0.010336184874176979, 0.011805559508502483, -0.004921367857605219, 0.0030472928192466497, 0.008530676364898682, 0.021719172596931458, 0.024328526109457016, -0.0004459479823708534, 0.008274072781205177, 0.01707490161061287, -0.0044074105098843575, -0.007540042977780104, -0.006096153520047665, 0.00015797477681189775, 0.01576203480362892, -0.0033530460204929113, -0.00246357056312263, 0.005684587638825178, -0.010829376056790352, -0.005291394889354706, -0.0035943600814789534, 0.043391138315200806, 0.0030933571979403496, -0.01170331984758377, 0.0027333053294569254, 0.01512253750115633, 0.009979011490941048, -0.008904592134058475, 0.016696058213710785, -0.00696706585586071, -0.01324381958693266, 0.010564446449279785, -0.00575921218842268, 0.004509108141064644, -0.015743708238005638, 0.017084361985325813, 0.005120604764670134, 0.012731177732348442, -0.01336518581956625, 0.0027662627398967743, 0.013855425640940666, 0.004595662467181683, 0.0027799373492598534, 0.006751024164259434, 0.013313043862581253, 0.023911621421575546, 0.032234661281108856, 0.019503852352499962, -0.01878591813147068, 0.015036270022392273, 0.004593269899487495, -0.015171036124229431, 0.016112353652715683, -0.004625165369361639, 0.026186639443039894, -0.019574519246816635, 0.011209364980459213, 0.011304213665425777, 0.0067265830002725124, 0.007281420286744833, 0.010278379544615746, 0.032693393528461456, 0.006885344162583351, 0.007539022248238325, 0.012277602218091488, 0.007162400986999273, 0.03347378969192505, 0.0009971072431653738, 0.0058607980608940125, -0.004717099480330944, 0.013394194655120373, 0.022015439346432686, 0.022432152181863785, -0.0010594760533422232, -0.019638776779174805, -0.015551066026091576, -0.006869854871183634, 0.010545073077082634, 0.012824694626033306, -0.0003999467007815838, 0.027180852368474007, 0.005830134265124798, 0.001252354122698307, 0.0022786944173276424, 0.008561312220990658, -0.0026476560160517693, -0.00823827926069498, -0.01648624986410141, 0.010797386057674885, -0.012883617542684078, -0.011878592893481255, -0.0005497043021023273, 0.0039220042526721954, -0.012408523820340633, -0.00037132645957171917, -0.018598172813653946, -0.022754274308681488, -0.01038195751607418, 0.018561456352472305, 0.00614141346886754, 0.013854674063622952, 0.019989600405097008, 0.007449575234204531, -0.004537774249911308, 0.012220383621752262, 0.025486810132861137, 0.021195504814386368, 0.00011912849731743336, -0.014640958979725838, -0.013150036334991455, 0.03465408459305763, 0.02453155443072319, -0.002294030971825123, -0.002577385166659951, 0.009744636714458466, 0.004998069256544113, 0.005374381318688393, 0.002075895667076111, 0.012043995782732964, 0.0036886208690702915, 0.007969453930854797, 0.007981125265359879, 0.008169860579073429, -0.0016838721930980682, -0.005500694736838341, 0.013678798452019691, 0.033805787563323975, 0.001456777798011899, -0.040569379925727844, -0.0050908224657177925, 0.0037679176311939955, 0.008534718304872513, 0.0017757380846887827, 0.017918873578310013, -0.03852290287613869, 0.025209546089172363, -0.006258508190512657, -0.02832125872373581, 0.0140376640483737, -0.00539220729842782, 0.011331313289701939, -0.01388427522033453, 0.0057874564081430435, -0.005821008235216141, 0.02025207318365574, -0.011153880506753922, -0.0029679450672119856, -0.0018182292114943266, 0.00891982764005661, 0.012656809762120247, 0.0030072287190705538, 0.025616727769374847, -0.016652654856443405, -0.000016602687537670135, -0.007946951314806938, 0.016992829740047455, 0.004950482398271561, -0.008196837268769741, -0.005736895836889744, 0.012248702347278595, -0.00014060887042433023, -0.02667156234383583, -0.026175782084465027, -0.019203035160899162, 0.0054857442155480385, -0.017010221257805824, 0.003456795820966363, 0.039443500339984894, -0.043700192123651505, 0.028005395084619522, -0.005019724369049072, 0.016411609947681427, -0.010388238355517387 ]
[ 0.5295032262802124, 0.01744164153933525, 0.24251730740070343, 0.2036057561635971, -0.3213333785533905, -0.19284918904304504, -0.01301640085875988, -0.24880774319171906, 0.3460606634616852, -0.45358705520629883, -0.014904542826116085, 0.3424990773200989, 0.012363920919597149, 0.229469895362854, -0.5090813040733337, 0.44206151366233826, 0.39861294627189636, 0.638609766960144, -0.13604134321212769, -0.976551353931427, -0.1619146168231964, -0.2483931928873062, 0.7373584508895874, -0.2749347388744354, 0.26913198828697205, 0.4160149395465851, 0.07565218210220337, 0.01051421370357275, 0.4302033483982086, -0.036237191408872604, 0.04147496446967125, 0.2584131360054016, 0.3195090889930725, -0.036605820059776306, -0.3469651937484741, -0.020823722705245018, -0.6915180683135986, -0.11691864579916, 0.03974616900086403, -0.4275340139865875, -0.3314855992794037, -0.5628563761711121, -0.09266924858093262, 0.2583819627761841, -0.36748048663139343, 0.4132685959339142, -1.3480397462844849, 0.6796681880950928, -0.5561515688896179, -0.03243659436702728, -0.20615099370479584, 0.003919214475899935, 0.3248237073421478, 0.021273909136652946, 0.7636217474937439, 0.09296698123216629, -1.1717897653579712, -0.35337886214256287, 0.6080542206764221, -0.28689923882484436, -0.4950879216194153, 0.033097926527261734, -0.1278647929430008, 0.07601996511220932, 0.17877301573753357, 0.19572338461875916, 0.01945030875504017, -0.49117276072502136, -0.6670404076576233, 0.232108011841774, 0.5590403079986572, -0.21966521441936493, -0.024233518168330193, 0.5938854813575745, 0.06884629279375076, -0.35117480158805847, -0.744440495967865, 0.05682050809264183, 0.3816513121128082, 0.43714913725852966, 0.017999308183789253, 0.02725912444293499, 0.4752543270587921, 0.16058696806430817, 0.34576258063316345, 0.2858359217643738, 0.002499303314834833, 0.42894595861434937, -0.9279236793518066, 0.13890576362609863, -0.3046148717403412, -0.06943988054990768, 0.04120286926627159, 0.2144365757703781, -0.3010569214820862, 0.43359941244125366, -0.38463979959487915, -0.25508105754852295, -0.018159786239266396, 0.218084454536438, -0.033261608332395554, 0.14423054456710815, -0.00006872132507851347, -0.5049847364425659, -0.532214343547821, -0.3849011957645416, -0.502738893032074, -0.6983950734138489, -0.14946210384368896, -0.0500507615506649, -0.6764828562736511, -0.03976167365908623, -0.5491241216659546, 0.12539294362068176, 0.2811667323112488, 0.21680575609207153, 0.11661083996295929, -0.1844184696674347, 0.16435813903808594, -0.18041934072971344, -0.3144596815109253, 0.8736856579780579, 0.4801725745201111, 0.4085789620876312, 0.112580806016922, 0.33716851472854614, -0.04203912243247032, -0.08337096124887466, 0.364023357629776, 0.3099486827850342, 0.5071162581443787, 0.6864907145500183, 0.10931189358234406, -0.11538229882717133, 0.0020014243200421333, -0.3050747811794281, 0.32577869296073914, -0.0717795193195343, 0.33795008063316345, 0.4948309659957886, -0.4458012282848358, -0.16307471692562103, -0.06412613391876221, 0.0838313177227974, 0.039322979748249054, -0.18227890133857727, -0.5053358674049377, 0.47404998540878296, -0.09805185347795486, 0.3095153868198395, 0.13746479153633118, -0.4264145493507385, -0.6322087049484253, -0.30279719829559326, 0.042669378221035004, 0.3431871235370636, -0.035929735749959946, 0.23033598065376282, 0.05038956552743912, 0.12763509154319763, -0.07679203152656555, -0.2587905526161194, -0.1206250786781311, -0.14392781257629395, 0.6429039239883423, -0.4083082675933838, 0.16726011037826538, 0.32157862186431885, -0.2578672170639038, 0.2912308871746063, -0.34402087330818176, -0.8722822666168213, -0.3004291355609894, -0.43210673332214355, -0.1826654076576233, -0.2634507715702057, -0.09763862937688828, -0.24381649494171143, 0.20789092779159546, -0.0809435173869133, -0.8437215685844421, 0.5236371159553528, 0.03317229822278023, -0.5190575122833252, 0.3652046024799347, 0.3618529140949249, 0.9609143137931824, -0.0015756309730932117, -0.17921091616153717, 0.0861731618642807, -0.08935003727674484, -0.23637224733829498, 0.8754792809486389, -0.6601942777633667, 1.2324880361557007, -0.07562952488660812, 0.0018057733541354537, 0.23431049287319183, 0.12422648072242737, 0.08973850309848785, -0.21424922347068787, -0.025559475645422935, 0.7084137797355652, -0.7440862059593201, -0.5557507276535034, 0.0690343827009201, -0.23315107822418213, -0.4541073739528656, -0.06234963610768318, -0.1803307831287384, 0.04480891302227974, -0.39454618096351624, 0.1500556319952011, 0.046325333416461945, 0.14419890940189362, -0.8724462985992432, 0.43758875131607056, -0.20876403152942657, -0.14941392838954926, -0.3308912217617035, 0.27886849641799927, -0.3574623763561249, 0.2483295500278473, 0.7314932346343994, -0.4018399119377136, 0.5665338635444641, 0.41575175523757935, 0.20294640958309174, 0.8291156888008118, 0.29991984367370605, 0.3175809383392334, -0.1519375443458557, 0.06144341453909874, -0.23706723749637604, 0.5067625641822815, -0.1710001528263092, 0.09595905989408493, -0.07524910569190979, 0.253391832113266, -0.0698457658290863, -0.06737394630908966, 0.587937593460083, -0.7063496112823486, -0.15195739269256592, 0.3777755796909332, -0.15409153699874878, -0.3596460819244385, 0.5335990190505981, -1.0741528272628784, -0.28696590662002563, -0.28979507088661194, 0.07994617521762848, 0.21451079845428467, -0.6270702481269836, -0.19546589255332947, -0.06826277077198029, -0.1414925903081894, -0.1701415628194809, -0.1586095243692398, 0.08118195831775665, -0.3108043372631073, -0.2422446608543396, -0.008917061612010002, 0.11755935102701187, 0.40077725052833557, -0.5473371744155884, -0.6534333229064941, -0.31457585096359253, 1.3448044061660767, 0.5043148994445801, 0.9740129113197327, -0.5681358575820923, -0.6993157267570496, -0.4786206781864166, -0.15291520953178406, -0.5620051622390747, -0.27762070298194885, 0.46333828568458557, -0.12096904963254929, -0.6338903307914734, -0.04349469766020775, 0.4201413094997406, 0.6690285205841064, -0.13001972436904907, -0.28131023049354553, 0.47590792179107666, -0.43783509731292725, -0.6567060947418213, -0.17650200426578522, -0.846407413482666, 0.4431992173194885, 0.42465391755104065, -0.2818593978881836, -0.14885856211185455, 0.19478482007980347, -0.0009577929740771651, -0.009074189700186253, 0.5237914323806763, 0.544874906539917, -0.16502143442630768, -0.0053682173602283, 0.40315747261047363, -0.2912956774234772, 0.1188569962978363, 0.1359778195619583, 0.12573778629302979, 0.09235396236181259, -0.056321047246456146, -5.78699254989624, -0.18502384424209595, -0.26086026430130005, -0.22381307184696198, 0.5738484859466553, -0.37653857469558716, 0.9907382130622864, 0.2043183594942093, 0.22105687856674194, 0.4322759211063385, 0.14528080821037292, 0.03446225821971893, 0.009455841034650803, -0.18876321613788605, -0.353567510843277, -0.3924117386341095, -0.1641257256269455, -0.08542032539844513, 0.9496784806251526, 0.05019848421216011, 0.41152194142341614, -0.5151174068450928, 0.12168862670660019, 0.6098080277442932, 0.13521094620227814, -0.5295590162277222, -0.7435160279273987, 0.12413573265075684, -0.42961621284484863, -0.45786598324775696, 0.11132216453552246, -0.1636352688074112, -0.41331833600997925, -0.4799143671989441, 0.2841688394546509, -0.32274577021598816, 0.33986520767211914, -0.09080957621335983, -0.36347147822380066, -0.31993693113327026, 0.4609682559967041, -0.06960215419530869, 0.4070894718170166, -0.6195886731147766, 0.5312317609786987, 0.08794242143630981, 0.006800878793001175, -0.19298483431339264, -0.16815969347953796, 0.7612070441246033, -0.14459575712680817, -0.19719456136226654, 0.34019187092781067, 0.2629854381084442, 0.687499463558197, -0.12004157900810242, -0.19923053681850433, 0.24696636199951172, -0.1990564912557602, 0.3161528408527374, -0.13528569042682648, -0.2095109224319458, -0.17111167311668396, -1.1041793823242188, 0.018916603177785873, 0.4294525980949402, -0.5589464902877808, -0.06422266364097595, 0.18583911657333374, -0.35740235447883606, -0.3691495954990387, 0.16712813079357147, 0.0647626519203186, -0.8138920068740845, 0.5706391334533691, -0.5920026898384094, 0.22073212265968323, 0.48009103536605835, -0.5656346082687378, 0.3433547019958496, -0.2789183557033539, -0.5380553007125854, -0.06661863625049591, 0.3478091359138489, 0.40629884600639343, -0.2770863473415375, -0.514803409576416, -0.11630236357450485, 0.15491311252117157, 0.3520132005214691, 0.19411048293113708, -0.11325673758983612, 0.094268798828125, 0.2873700261116028, -0.05665348470211029, -0.25597426295280457, 0.13297715783119202, 0.5759485960006714, 0.14992284774780273, -0.02217904105782509, 0.5214253067970276, 0.4241146743297577, -0.1909365952014923, 0.10347031056880951, -0.30918219685554504, -0.3841908574104309, -0.053274188190698624, 0.08261194080114365, 0.7871560454368591, -0.5102565884590149, 0.09020819514989853, -0.24354295432567596, -0.9752858281135559, -0.1369953602552414, 0.6554227471351624, 0.05462715029716492, -0.19120268523693085, -0.10169859230518341, 0.880776047706604, -0.19750139117240906, 0.18849927186965942, 0.6149547696113586, -1.0076688528060913, 0.13273121416568756, -0.1653336137533188, -0.33472636342048645, 0.25083476305007935, 0.5975548028945923, -0.4151677191257477, -0.313275009393692, -0.13640634715557098, 0.1339346319437027, -0.15211983025074005, -0.14350681006908417, 0.2574603259563446, -0.05052813142538071, -0.09421144425868988, 0.5249667167663574, -0.05187613144516945, -0.12784899771213531, 0.36043041944503784, -0.4435988962650299, 0.1758737564086914, 0.11410047113895416, 0.6976805329322815, 0.2609972655773163, -0.07477902621030807, -0.01537777204066515, -0.4708123207092285, -0.12324560433626175, 0.8626581430435181, -0.12228558212518692, 0.28052443265914917, 0.18348877131938934, 0.1216365173459053, 0.2075617015361786, 0.4857010841369629, 0.21988430619239807, 0.12023665755987167, -0.6378569602966309, 0.2521558701992035, 0.1357136368751526, -0.593643069267273, 0.181416854262352, 0.12082843482494354, -0.3200192451477051, -0.2371961772441864, -0.3374887704849243, -0.30312010645866394, -0.1779768168926239, -0.4379737079143524, -0.430385559797287, -0.04235684126615524, 0.07541006058454514, -0.04535853490233421, -0.1427799016237259, -0.34064170718193054, 0.18973028659820557, 0.11870521306991577, -0.23087038099765778, -0.0095340171828866, -0.1871323585510254, 0.269447922706604, -0.08011942356824875, 0.14079050719738007, 0.3850221335887909, -0.129208043217659, 0.08989875763654709, -0.13521602749824524, -0.3465958535671234, 0.27150532603263855, -0.08751051127910614, -0.05903899669647217, 0.3548421859741211, 0.2698385417461395, 0.2025846540927887, 0.5060202479362488, 0.6945894956588745, 0.21431441605091095, -0.40662074089050293, 0.15425825119018555, 0.32860326766967773, 0.16264018416404724, 0.0644209235906601, 0.7126766443252563, 0.08989884704351425, -0.0730607882142067, 0.4882909059524536, -0.4540490210056305, -0.42064258456230164, 0.021554846316576004, -1.0152862071990967, 0.501338541507721, -0.11716969311237335, -0.37913647294044495, -0.36547619104385376, 0.6800282597541809, -0.09872687608003616, -0.05238815024495125, 0.02730175480246544, 0.5377881526947021, 0.19962981343269348, -0.006717829033732414, -0.4262361228466034, -0.8450510501861572, 0.16379688680171967, 0.6663041114807129, -0.20822001993656158, 0.21512262523174286, -0.01733900047838688, -0.057830747216939926, 0.059657443314790726, 0.04280959442257881, 0.024975309148430824, -0.3134973645210266, -0.5490261912345886, -0.10905344039201736, 0.3878307044506073, -0.036377523094415665, 0.012465165928006172, 0.2108861356973648, 0.40452149510383606, 0.02189495787024498, 0.0800321102142334, -0.28361183404922485, 0.9148600697517395, 0.12815982103347778, -0.6430202126502991, -0.21077929437160492, 0.3656316101551056, 0.3853282928466797, -0.10716135054826736, -0.10225354135036469, 0.376384437084198, 1.0412006378173828, 0.0006577090825885534, -0.10012560337781906, -0.3966384828090668, -0.38703227043151855, 0.3173943758010864, -0.3765312135219574, 0.4531024992465973, -0.11427918076515198, 0.26052841544151306, 0.10225939005613327, 0.35616984963417053, -0.6479139924049377, -0.3946385681629181, 0.6071522831916809, -0.3900007903575897, -0.2581014335155487, -0.1824169009923935, 0.38128504157066345, 0.5892879962921143, 0.22131401300430298, 0.2773986756801605, -0.11538123339414597, -0.3480277955532074, -0.22765949368476868, -0.06232277676463127, 0.04173678904771805, -0.07543428242206573, 0.5823777914047241, -0.18110500276088715, -0.16261351108551025, -0.6111211180686951, -0.6780721545219421, -0.7116366028785706, -0.09456231445074081, 0.17089779675006866, -0.4230102300643921, 0.11064102500677109, -0.7378950715065002, -0.6411581635475159, 0.09655090421438217, 0.26207053661346436, 0.3516687750816345, 0.2686693072319031, 0.17479217052459717, 0.47949498891830444, -0.25631996989250183, 0.6176612973213196, 0.8759840726852417, -0.3639621138572693, -0.37233203649520874, 0.36301368474960327, 0.04052964225411415, -0.08928031474351883, -0.1769605278968811, 0.006771970074623823, 0.13963648676872253, -0.29574114084243774, 0.4723588824272156, -0.023201989009976387, -0.36575618386268616, 0.023259541019797325, 0.11814295500516891, -0.04876088351011276, -0.2465948760509491, 0.26919254660606384, 0.6709448099136353, 0.514339804649353, 0.8090082406997681, -0.05472855642437935, -0.13464149832725525, 0.31955835223197937, 0.20524460077285767, -0.4085141122341156, 0.017659276723861694, 0.6564725637435913, 0.4837920367717743, 0.4833256006240845, -0.11547353863716125, 0.9281353950500488, 0.5071972608566284, 0.10237353295087814, -0.40168967843055725, 0.09757014364004135, 0.009527431800961494, 0.10110059380531311, 0.6917603015899658, 0.15104368329048157, -0.35991644859313965, -0.04519565403461456, 0.5635806918144226, 0.25671306252479553, 0.061622194945812225, -0.30482053756713867, 0.0020706632640212774, 0.6097985506057739, 0.25761938095092773, -0.5750313997268677, -0.5710644721984863, -0.03040219470858574, -0.8620597720146179, 0.12337355315685272, 0.03327808901667595, -0.024037962779402733, -0.5825232267379761, 0.41769975423812866, -0.6883020997047424, 0.03497378155589104, 0.46459850668907166, 0.6464483737945557, -0.36467409133911133, 0.102769635617733, 0.23452161252498627, -0.1125861182808876, 0.45091286301612854, 0.03938153013586998, -0.4090271294116974, 0.04604480415582657, -0.16371123492717743, 0.38495156168937683, 0.38395825028419495, -0.4370928108692169, 0.09885258227586746, -0.21609389781951904, -0.15780650079250336, 0.04458211362361908, -0.521381139755249, -0.03985879197716713, -0.3826220631599426, -0.6331057548522949, -0.17046354711055756, -0.002370538655668497, -0.14942140877246857, -0.2962946593761444, -0.37000712752342224, 0.4505290389060974, 0.20278099179267883, -0.5012342929840088, 0.8379769325256348, -0.24583838880062103, -0.13839194178581238, 0.10688785463571548, -0.46896690130233765, -0.03939245268702507, 0.30760279297828674, 0.015168851241469383, -0.1746578812599182, 0.6787285208702087, -0.032053254544734955, 0.18743246793746948, -0.17923887073993683, 0.3866759240627289, -0.4709077477455139, -0.20709215104579926, -0.1942150592803955, -0.2649841010570526, 1.3271839618682861, 0.9410011172294617, -0.1600806564092636, 0.12994684278964996, 0.23768290877342224, 0.20827805995941162, 0.3053845465183258, -0.4653480648994446, -0.31925252079963684, -0.321675568819046, -0.3082275986671448, -0.04419270157814026, 0.7384307384490967, 0.12957356870174408, -0.29277515411376953, -0.13828632235527039, 0.7264876365661621, 0.11627589911222458, -0.7205792665481567, 0.3090631365776062, -0.14252156019210815, 0.3459380865097046, -0.5480794310569763, 0.329023152589798, -0.6615331768989563, 0.2855589985847473, -0.44030362367630005, 0.35206690430641174, -0.14725810289382935, -0.07777362316846848, -0.06081545725464821, 0.2202027440071106, -0.02579909935593605, 0.06884881854057312, -0.20909805595874786, -0.16657763719558716, -0.2160836011171341, -1.1473833322525024, -1.224985122680664, -0.25723016262054443, 0.511603057384491, -0.3818994462490082, -0.29633140563964844, -0.043940719217061996, 0.09172629565000534, -0.4909840524196625, 0.5263826847076416, -0.3877706527709961, 0.20611783862113953, 0.3149038255214691 ]
BACKGROUND LDL cholesterol has a causal role in the development of cardiovascular disease. Improved understanding of the biological mechanisms that underlie the metabolism and regulation of LDL cholesterol might help to identify novel therapeutic targets. We therefore did a genome-wide association study of LDL-cholesterol concentrations. METHODS We used genome-wide association data from up to 11,685 participants with measures of circulating LDL-cholesterol concentrations across five studies, including data for 293 461 autosomal single nucleotide polymorphisms (SNPs) with a minor allele frequency of 5% or more that passed our quality control criteria. We also used data from a second genome-wide array in up to 4337 participants from three of these five studies, with data for 290,140 SNPs. We did replication studies in two independent populations consisting of up to 4979 participants. Statistical approaches, including meta-analysis and linkage disequilibrium plots, were used to refine association signals; we analysed pooled data from all seven populations to determine the effect of each SNP on variations in circulating LDL-cholesterol concentrations. FINDINGS In our initial scan, we found two SNPs (rs599839 [p=1.7x10(-15)] and rs4970834 [p=3.0x10(-11)]) that showed genome-wide statistical association with LDL cholesterol at chromosomal locus 1p13.3. The second genome screen found a third statistically associated SNP at the same locus (rs646776 [p=4.3x10(-9)]). Meta-analysis of data from all studies showed an association of SNPs rs599839 (combined p=1.2x10(-33)) and rs646776 (p=4.8x10(-20)) with LDL-cholesterol concentrations. SNPs rs599839 and rs646776 both explained around 1% of the variation in circulating LDL-cholesterol concentrations and were associated with about 15% of an SD change in LDL cholesterol per allele, assuming an SD of 1 mmol/L. INTERPRETATION We found evidence for a novel locus for LDL cholesterol on chromosome 1p13.3. These results potentially provide insight into the biological mechanisms that underlie the regulation of LDL cholesterol and might help in the discovery of novel therapeutic targets for cardiovascular disease.
[ 0.021109111607074738, 0.011574791744351387, -0.01715661957859993, 0.023577965795993805, 0.0361846424639225, 0.0018442366272211075, 0.00955437496304512, -0.0025035652797669172, -0.014930193312466145, -0.029172739014029503, 0.012420696206390858, 0.013553593307733536, -0.017132682725787163, 0.006439375691115856, 0.0029939748346805573, 0.00012390862684696913, -0.03644025698304176, 0.0016250470653176308, 0.010906631126999855, 0.0017825933173298836, 0.014882120303809643, -0.012720330618321896, 0.011404837481677532, 0.033110495656728745, -0.004839550703763962, 0.009357644245028496, -0.020865654572844505, -0.01986691914498806, -0.006193577777594328, -0.018809771165251732, 0.027023499831557274, -0.020538894459605217, 0.021895892918109894, 0.028801191598176956, 0.005078967195004225, 0.012515559792518616, 0.006889810785651207, 0.02164779044687748, 0.009081334806978703, -0.0030126473866403103, -0.0010410225950181484, -0.009060410782694817, 0.0030196693260222673, -0.0036801486276090145, -0.010574620217084885, -0.0016997656784951687, -0.005512448027729988, 0.025600243359804153, 0.009895609691739082, 0.014757460914552212, -0.01275715697556734, -0.031094765290617943, -0.006738655269145966, 0.03528393432497978, -0.006804889999330044, 0.03023514337837696, 0.02316705510020256, -0.0064850617200136185, -0.026216475293040276, 0.02416764758527279, 0.005559232085943222, 0.026742327958345413, -0.0024357889778912067, 0.002531804144382477, -0.009341917000710964, -0.06685232371091843, 0.00795692391693592, 0.01079528871923685, 0.0036781441885977983, -0.013625726103782654, -0.013601699844002724, 0.013119487091898918, 0.017169980332255363, -0.0008443653350695968, 0.008881418965756893, -0.004285209812223911, 0.010702489875257015, -0.005172167904675007, 0.040358640253543854, -0.007462367881089449, -0.007731281220912933, 0.0006261483067646623, -0.006713543552905321, 0.029159553349018097, -0.0007594262715429068, -0.004438693635165691, -0.023908790200948715, -0.030177056789398193, 0.011446265503764153, 0.009709147736430168, 0.006428798660635948, -0.012715496122837067, -0.0008447631262242794, -0.013465294614434242, -0.05640287324786186, -0.003922253847122192, -0.004246261902153492, 0.009848395362496376, 0.014169865287840366, -0.011349771171808243, 0.0011907032458111644, 0.0007914518937468529, 0.018321022391319275, 0.011329262517392635, -0.015826324000954628, 0.008340185508131981, -0.019040731713175774, 0.016874579712748528, -0.009321664460003376, 0.004616572521626949, 0.017815396189689636, 0.02061205729842186, -0.005810410249978304, 0.009627999737858772, 0.014678438194096088, 0.003964396193623543, 0.017204629257321358, 0.03819417953491211, 0.0015551793621852994, -0.01978861168026924, 0.0017964672297239304, 0.00373206939548254, -0.006461214739829302, 0.03793177008628845, 0.0034102085046470165, 0.009507618844509125, 0.031224213540554047, 0.02570240944623947, 0.02033199556171894, 0.012048237025737762, -0.005221666302531958, -0.013737845234572887, 0.010135676711797714, 0.004415865056216717, -0.004625398200005293, 0.003809517715126276, 0.008873804472386837, -0.012994610704481602, -0.01072552427649498, -0.03275047615170479, -0.023380406200885773, 0.011999417096376419, -0.004339967388659716, 0.01218823716044426, 0.0013898205943405628, 0.004610330797731876, 0.03302338719367981, -0.014226880855858326, 0.0029780473560094833, -0.018124505877494812, 0.008429037407040596, -0.014324436895549297, 0.0009590076515451074, -0.019689565524458885, -0.009904740378260612, 0.026405658572912216, -0.00635910127311945, -0.0031463196501135826, 0.004519968293607235, 0.022192299365997314, -0.008238960057497025, -0.02003755047917366, 0.011401614174246788, 0.010309013538062572, 0.012399273924529552, 0.022556491196155548, -0.0007716389372944832, -0.016181383281946182, -0.018375709652900696, -0.0017027584835886955, -0.005809121765196323, 0.013629411347210407, 0.018797636032104492, 0.016395024955272675, -0.01857711933553219, 0.0010612119222059846, -0.012609635479748249, 0.007935010828077793, 0.0019149873405694962, 0.06648042798042297, 0.02438923716545105, 0.012706510722637177, 0.011176100932061672, -0.015522515401244164, 0.02019943669438362, -0.0307276900857687, 0.006474223453551531, -0.006874172016978264, -0.025774765759706497, -0.02670201286673546, 0.017046164721250534, 0.017590347677469254, 0.013746276497840881, -0.0030533461831510067, -0.013386323116719723, 0.0017525556031614542, 0.01104336604475975, -0.02171381749212742, 0.0022466338705271482, 0.010504120960831642, 0.007480143569409847, -0.008605670183897018, 0.022086651995778084, -0.012100087478756905, -0.01840108633041382, 0.0181816928088665, 0.025922264903783798, -0.0076363892294466496, 0.020780492573976517, 0.016787121072411537, 0.03437444940209389, 0.0016272184439003468, -0.01604008674621582, 0.00047002953942865133, -0.012628461234271526, 0.001396080944687128, -0.045144710689783096, -0.014303221367299557, -0.001231514848768711, -0.022968798875808716, 0.006207577418535948, -0.005063680931925774, -0.0022948822006583214, -0.016338743269443512, 0.014847178012132645, -0.023622464388608932, 0.004415940493345261, 0.006676532793790102, 0.01278169546276331, -0.010759367607533932, -0.020400097593665123, -0.011433976702392101, -0.01116922590881586, 0.030906392261385918, 0.0159930270165205, 0.009985893964767456, 0.017312809824943542, 0.0014798096381127834, 0.00858873687684536, -0.014057127758860588, 0.0022010039538145065, -0.04427461326122284, 0.013132899068295956, 0.0006870795041322708, 0.004228590987622738, -0.0014386498369276524, 0.0018507796339690685, 0.01874273270368576, 0.004830239340662956, -0.0316016748547554, 0.00486161932349205, -0.008898572996258736, -0.0029425041284412146, -0.026325009763240814, 0.01917380467057228, -0.005320418160408735, 0.024358950555324554, -0.024080125615000725, 0.026365356519818306, -0.0012702858075499535, 0.013103045523166656, 0.005429066717624664, 0.010724187828600407, 0.006700779777020216, 0.006124231964349747, 0.006695611402392387, 0.02983437106013298, 0.028639676049351692, 0.0178139116615057, -0.00965803861618042, 0.007656705100089312, -0.006728576961904764, -0.002665438689291477, -0.08103179186582565, -0.019526096060872078, -0.0020557749085128307, 0.008061980828642845, 0.01658320426940918, 0.003341309493407607, -0.018874377012252808, 0.006695810705423355, 0.0008570824284106493, -0.011683588847517967, 0.01693168841302395, 0.03387003391981125, -0.009546604007482529, 0.013312246650457382, 0.0065130870789289474, -0.00890345312654972, 0.005587609484791756, 0.005231751129031181, 0.010761197656393051, -0.011363931000232697, 0.002543409587815404, -0.03991764783859253, -0.0006932122632861137, -0.01439934317022562, 0.003596247173845768, -0.0038198810070753098, 0.002683150116354227, -0.01255374401807785, 0.012121830135583878, 0.010291855782270432, -0.040653251111507416, -0.013574160635471344, 0.010631414130330086, -0.011677847243845463, 0.0003841221332550049, -0.018842145800590515, 0.007000381592661142, 0.01854563131928444, -0.016635984182357788, 0.01103329285979271, -0.00012330111349001527, 0.012589296326041222, -0.022092580795288086, -0.002145492471754551, 0.015776313841342926, 0.00651867501437664, 0.0138158667832613, 0.029371321201324463, 0.018251800909638405, 0.015323681756854057, 0.001006009872071445, 0.013257501646876335, 0.002503737108781934, 0.01409430243074894, -0.010374125093221664, -0.008157135918736458, -0.00694449944421649, 0.02813590317964554, -0.011734465137124062, -0.016000326722860336, -0.006545985117554665, -0.026860669255256653, -0.023423336446285248, 0.028175776824355125, 0.012726109474897385, 0.01625608652830124, 0.010881052352488041, -0.0023497717920690775, 0.018655605614185333, -0.0008937263628467917, -0.003832987044006586, -0.01740950159728527, -0.006964880041778088, 0.0009614287409931421, -0.025537721812725067, -0.010516408830881119, -0.016441039741039276, -0.0019133958267048001, 0.01653878204524517, -0.005199282430112362, -0.005372918210923672, 0.014683064073324203, -0.007864190265536308, -0.01092598121613264, -0.0035795343574136496, -0.020877819508314133, 0.008373428136110306, 0.014955063350498676, 0.020393887534737587, -0.013222547248005867, -0.019332755357027054, 0.005546091124415398, 0.007350040599703789, 0.00500831101089716, -0.013858522288501263, -0.023695291951298714, -0.0032686996273696423, -0.00729159964248538, 0.009217149578034878, 0.00935776811093092, -0.002016172744333744, 0.010633333586156368, 0.01855320855975151, -0.013734230771660805, -0.010829281993210316, 0.008372832089662552, 0.00355400238186121, 0.025304710492491722, 0.0021131648682057858, -0.006514502223581076, -0.01644342765212059, -0.001078037079423666, 0.00144884642213583, 0.03809363394975662, 0.012259252369403839, 0.040966976433992386, 0.01606753095984459, 0.008218523114919662, 0.07170812040567398, 0.01372084952890873, -0.004146638326346874, -0.015782903879880905, 0.008019626140594482, -0.038528356701135635, -0.02876107394695282, 0.02076648734509945, -0.011335067451000214, -0.012262824922800064, 0.013843460008502007, 0.016725419089198112, 0.0005211663083173335, -0.015984661877155304, -0.007687080185860395, 0.006357433274388313, -0.0136021189391613, 0.012413637712597847, 0.004355481825768948, -0.012764119543135166, -0.01884925179183483, -0.012974374927580357, -0.032655708491802216, -0.008441492915153503, 0.012624931521713734, -0.021358400583267212, -0.01069071888923645, -0.015000449493527412, -0.019373003393411636, 0.005851426161825657, 0.02166477032005787, 0.010410590097308159, -0.0040542930364608765, 0.026323240250349045, -0.0169976856559515, 0.015215708874166012, 0.04620856046676636, 0.00992337055504322, 0.02692217379808426, 0.0014835493639111519, -0.029301661998033524, -0.008882658556103706, 0.032174427062273026, 0.011387722566723824, -0.0039762710221111774, 0.0087584825232625, 0.007861671969294548, -0.0034149736166000366, -0.028152314946055412, -0.005751302931457758, -0.0036243442445993423, 0.0021638143807649612, 0.017745591700077057, 0.03382471948862076, -0.004825722426176071, -0.025167806074023247, -0.0018188429530709982, -0.009122125804424286, -0.011339031159877777, -0.014363923110067844, -0.02002818137407303, 0.005925753153860569, 0.021084899082779884, -0.01803932711482048, -0.013521019369363785, -0.0038598293904215097, -0.004601845517754555, -0.008868193253874779, -0.0052243685349822044, 0.0012535410933196545, 0.0005281481426209211, 0.005828243680298328, -0.008987992070615292, -0.007006505969911814, -0.04604841023683548, -0.023478833958506584, -0.01178918220102787, 0.011394765228033066, -0.016050461679697037, 0.01293448731303215, -0.03680182248353958, 0.017802223563194275, -0.006739409174770117, -0.0382159948348999, 0.02979828044772148, -0.009376408532261848, -0.029979674145579338, -0.07463780045509338, 0.0053290450014173985, -0.01516388263553381, -0.00783180445432663, 0.008724486455321312, 0.007681107148528099, -0.0169081911444664, 0.03431107476353645, -0.00925524439662695, -0.0022255764342844486, -0.0011678417213261127, 0.002365703461691737, 0.016103971749544144, 0.013582980260252953, 0.01637830212712288, 0.012168753892183304, -0.011170202866196632, 0.006336810067296028, 0.003951257560402155, 0.014013532549142838, 0.025630993768572807, 0.029337311163544655, -0.0523700937628746, -0.003577473806217313, -0.004480897914618254, -0.08082987368106842, -0.0024313987232744694, -0.015908077359199524, -0.004737251903861761, -0.02021005004644394, -0.01605677604675293, 0.030119262635707855, -0.012599814683198929, -0.01793324202299118, -0.020233243703842163, -0.02818850800395012, 0.021197572350502014, -0.013916585594415665, -0.01754671335220337, -0.010424377396702766, -0.006514618173241615, 0.01849849708378315, 0.002200858201831579, 0.0011693816632032394, 0.037127215415239334, 0.002737885108217597, -0.0034362259320914745, -0.002160601317882538, 0.013389237225055695, -0.0005473712226375937, -0.005864483769983053, -0.016762517392635345, 0.008875247091054916, 0.0008973628282546997, -0.004509421065449715, -0.0027744383551180363, -0.018504636362195015, -0.00810214038938284, -0.0017259602900594473, -0.026896608993411064, -0.014098335057497025, -0.01246398314833641, -0.01601257361471653, 0.04527783393859863, -0.00812148954719305, -0.005677600856870413, 0.008416195400059223, -0.01887262985110283, -0.0035481113009154797, 0.027835998684167862, -0.02213304117321968, 0.007859748788177967, -0.0003018545685335994, -0.0011794257443398237, -0.02090425044298172, 0.0057988036423921585, -0.0038621495477855206, 0.023478427901864052, 0.001911067869514227, 0.006667885463684797, -0.00035685894545167685, -0.005448577925562859, 0.01628597266972065, 0.009670167230069637, 0.0047921775840222836, 0.00643215561285615, -0.010257234796881676, 0.022326432168483734, 0.07164477556943893, -0.038204774260520935, -0.007821573875844479, -0.011557982303202152, -0.010461797006428242, -0.007700488902628422, -0.021348468959331512, -0.004005547147244215, -0.008582181297242641, -0.031348709017038345, 0.007866701111197472, -0.0032248073257505894, 0.019073907285928726, 0.006078688893467188, -0.016437280923128128, 0.024096310138702393, 0.019938290119171143, 0.025754254311323166, -0.004549263510853052, -0.008288780227303505, 0.007324919104576111, -0.007329241838306189, 0.009010899811983109, 0.032538190484046936, 0.0005235127173364162, -0.012043403461575508, -0.013270110823214054, 0.010183528065681458, 0.01222638413310051, 0.021529650315642357, -0.02170305885374546, -0.0041321259923279285, 0.006189825013279915, 0.012900966219604015, 0.016412150114774704, 0.007222726009786129, -0.0253920741379261, 0.010164554230868816, -0.0335409939289093, -0.0031972816213965416, -0.01072814129292965, -0.007086541038006544, 0.0025681541301310062, 0.008468489162623882, 0.015724169090390205, -0.008225529454648495, -0.014362995512783527, 0.005345327779650688, -0.024243703112006187, -0.0021739730145782232, 0.023554962128400803, 0.002645358443260193, 0.031379181891679764, -0.01708104833960533, 0.018623296171426773, -0.00675406027585268, -0.03017127513885498, 0.020360764116048813, -0.0030775917693972588, -0.03772199526429176, -0.0016910627018660307, -0.014933692291378975, -0.0033091811928898096, -0.011793061159551144, 0.015459082089364529, -0.0013866915833204985, 0.016369003802537918, -0.017936279997229576, 0.006148417480289936, 0.00767464330419898, 0.014586616307497025, 0.013400362804532051, 0.004892046097666025, -0.001965766306966543, 0.02692236378788948, 0.006666769273579121, 0.004387197084724903, -0.027788959443569183, 0.023447535932064056, 0.005000893026590347, 0.00020825047977268696, 0.012214316986501217, 0.015384320169687271, 0.001666054129600525, -0.020079992711544037, 0.017170436680316925, -0.005477447062730789, 0.03291510045528412, -0.006308465264737606, 0.004251243080943823, -0.01562822237610817, -0.01921793445944786, -0.004767297767102718, 0.012158643454313278, 0.0023795028682798147, 0.03507138043642044, 0.01633017510175705, 0.0007822590414434671, 0.011265535838901997, -0.0007799370214343071, -0.0050516980700194836, -0.0021389005705714226, 0.014837997034192085, 0.00589666748419404, -0.013376892544329166, 0.010575898922979832, -0.006380756385624409, -0.014393344521522522, 0.028467901051044464, 0.03974948823451996, -0.018059372901916504, -0.016992656514048576, 0.013724511489272118, -0.012506913393735886, 0.01968732662498951, 0.013823027722537518, -0.0040826136246323586, -0.02321871928870678, -0.03198523819446564, -0.01952155865728855, -0.007026991341263056, -0.01071025338023901, -0.005139960907399654, 0.03615472838282585, 0.013594096526503563, -0.010937705636024475, -0.004218508955091238, 0.009611448273062706, 0.03188463672995567, 0.01881042867898941, 0.015616726130247116, 0.007164251524955034, -0.006644925102591515, 0.010795879177749157, 0.0220862478017807, -0.005565806291997433, 0.010468482971191406, 0.01303999312222004, 0.012791174463927746, -0.012756790034472942, 0.02712978795170784, -0.01854424551129341, -0.004740918055176735, -0.011460937559604645, 0.011039506644010544, -0.020481709390878677, -0.004463061690330505, 0.012474452145397663, 0.006624092813581228, 0.017802756279706955, -0.003695850959047675, 0.0040275901556015015, 0.01673603244125843, -0.0008796422043815255, -0.01229760143905878, 0.021011261269450188, 0.032900575548410416, 0.02534281462430954, -0.023250306025147438, -0.02441338822245598, 0.021622098982334137, 0.026867032051086426, 0.0037600556388497353, 0.004795948974788189, 0.01895301043987274, 0.012726869434118271, -0.01915181428194046, 0.020726043730974197, 0.017977649345993996, -0.025430195033550262, 0.009453095495700836, -0.02130473591387272, -0.030663635581731796, 0.032018594443798065, 0.0019272202625870705, 0.007023010402917862, 0.009895769879221916, 0.014886460267007351, -0.0036828932352364063, 0.01669987663626671, 0.004609604366123676, -0.0190042182803154, 0.0007430741097778082, -0.013157571665942669, 0.007333647925406694, -0.0035657668486237526, 0.005405298434197903, 0.0025117374025285244, -0.004777698777616024, -0.0028300548437982798, 0.02871343493461609, 0.015629593282938004, -0.029371650889515877, -0.01817706599831581, -0.011181579902768135, -0.01585470139980316, 0.0006519779562950134, -0.029716454446315765, 0.004603178706020117, -0.004544012248516083, -0.003294057212769985, 0.011664582416415215 ]
[ 0.34877660870552063, -0.1586502641439438, 0.12055524438619614, 0.033982910215854645, -0.058347683399915695, 0.10820517688989639, 0.0076754470355808735, 0.0970211997628212, -0.22294695675373077, -0.13794536888599396, 0.33195558190345764, 0.3157200813293457, -0.2635539770126343, 0.008235588669776917, 0.13500475883483887, 0.9507421851158142, 0.5024999380111694, 0.6404365301132202, -0.028619367629289627, -1.1043791770935059, -0.43508604168891907, -0.3162405788898468, 0.4714939296245575, -0.0932023748755455, 0.04848939925432205, 0.28093892335891724, 0.4479668438434601, -0.03281805291771889, 0.2769254744052887, 0.02339727245271206, -0.037801288068294525, 0.8775841593742371, 0.15976810455322266, -0.03386325389146805, -0.034203704446554184, -0.35164305567741394, -0.1387345939874649, 0.17358022928237915, 0.16142036020755768, 0.10839039832353592, -0.3041026294231415, -0.18422289192676544, -0.03012082539498806, 0.5836679339408875, 0.00472189811989665, -0.558485209941864, -0.8176522254943848, 0.6965196132659912, -0.2443559616804123, -0.1576031744480133, 0.5834270715713501, 0.5776519179344177, 0.08607030659914017, 0.30118173360824585, 0.13164569437503815, -0.018360115587711334, -0.6405905485153198, -0.2124062180519104, 0.2289595752954483, -0.23640066385269165, 0.13511791825294495, -0.3466029465198517, -0.14182446897029877, 0.10256935656070709, -0.14018023014068604, 0.5442744493484497, 0.33522316813468933, 0.11802326887845993, -0.22204084694385529, 0.16205090284347534, 0.24415943026542664, -0.21309344470500946, -0.5513554811477661, 0.12132641673088074, -0.07726230472326279, 0.2730655372142792, -0.1915089190006256, 0.13808341324329376, 0.17499850690364838, -0.12413990497589111, 0.1651938259601593, -0.061354972422122955, 0.36643698811531067, -0.25477129220962524, 0.5716351866722107, 0.46524617075920105, 0.12248744070529938, 0.7254023551940918, 0.03741498291492462, 0.024377277120947838, -0.27917584776878357, -0.00019933210569433868, 0.0972464457154274, 0.6038764119148254, -0.1471555531024933, 0.37873393297195435, 0.05574606731534004, 0.08286777138710022, 0.18122264742851257, 0.5751142501831055, -0.03923879191279411, 0.1356692761182785, 0.11293716728687286, -0.3444463312625885, -0.7037814259529114, -0.07091060280799866, -0.2885524332523346, -0.34805774688720703, -0.768013596534729, 0.24330013990402222, -0.9176523089408875, -0.03696703910827637, -0.5792249441146851, -0.38610199093818665, -0.10515115410089493, 0.01879100129008293, 0.4021610617637634, -0.7119564414024353, -0.0351564958691597, 0.1740972399711609, -0.5108479857444763, 1.008211612701416, -0.12292958050966263, 0.6825956106185913, 0.1391971856355667, 0.18673399090766907, 0.5235651135444641, 0.13788461685180664, 0.36927124857902527, 0.8480691909790039, 0.43479448556900024, 0.5684285759925842, -0.09362290054559708, 0.16895835101604462, -0.10838878899812698, -0.3345332741737366, 0.17287328839302063, 0.5921586155891418, 0.5009251832962036, -0.0737762600183487, -0.6707093715667725, -0.8534893989562988, -0.29534658789634705, 0.017856748774647713, 0.015796275809407234, -0.30578741431236267, -0.2752531170845032, -0.1372719705104828, -0.10505222529172897, -0.19983282685279846, 0.1510242223739624, -0.3717610239982605, -0.5248315334320068, -0.36804595589637756, -0.16453728079795837, 0.18306906521320343, -0.1921779364347458, -0.25920364260673523, -0.40007689595222473, 0.3626963198184967, 0.5312120914459229, 0.33881476521492004, -0.3243480920791626, 0.14148853719234467, 0.8464796543121338, -0.2905479073524475, -0.33183664083480835, -0.004009417723864317, -0.38371655344963074, 0.47181436419487, -0.5211856961250305, -0.05505133047699928, -0.44741809368133545, -0.9083878993988037, 0.07769829779863358, 0.03777388110756874, 0.17972196638584137, -0.04820657894015312, 0.1807614266872406, -0.23436897993087769, -0.534173309803009, -0.008070139214396477, 0.33624544739723206, -0.8325152397155762, 0.35318365693092346, 0.4025488495826721, 0.379849374294281, 0.15585973858833313, 0.28266850113868713, -0.0585864894092083, -0.41934916377067566, -0.21042808890342712, 0.6888242959976196, -0.7400406002998352, 1.4403387308120728, -0.698307991027832, 0.36568501591682434, 0.7999752759933472, 0.3936939239501953, -0.3503561019897461, -0.299894243478775, 0.024963023141026497, 0.8049267530441284, -0.24069517850875854, -1.214246153831482, -0.172215536236763, 0.02759590744972229, -0.35532480478286743, 0.08855924755334854, 0.08812488615512848, 0.2283453494310379, -0.06913639605045319, -0.370004266500473, -0.2452339231967926, -0.17163442075252533, 0.08652737736701965, -0.05428742617368698, 0.11026305705308914, 0.10710317641496658, -0.30088335275650024, 0.10258174687623978, -0.7988175749778748, 0.5574833154678345, 0.3825170397758484, -0.4693114459514618, 0.6248226761817932, 0.3230539858341217, -0.014618749730288982, 0.6552273631095886, -0.354030042886734, 0.22435197234153748, -0.40183156728744507, 0.3411751985549927, -0.6131852269172668, -0.17062558233737946, -0.045424867421388626, -0.17435447871685028, -0.1195545345544815, -0.35031214356422424, 0.02733762189745903, 0.2612306773662567, 0.31592807173728943, -0.8428579568862915, -0.0346752367913723, -0.11522820591926575, -0.36551159620285034, 0.09964033216238022, 0.21249791979789734, -0.8310777544975281, -0.07230143249034882, 0.12964144349098206, 0.17057430744171143, 0.23955635726451874, -0.5759921073913574, -0.2240481674671173, 0.0968121811747551, 0.018326276913285255, -0.7314021587371826, 0.20149323344230652, -0.7063345313072205, -0.02183518186211586, -0.009488665498793125, 0.19394564628601074, 0.17018729448318481, 0.16395001113414764, -0.8939045667648315, -0.4247699975967407, -0.6359754204750061, 1.150259017944336, 0.3900865912437439, 0.9069400429725647, 0.2407020628452301, -0.6773751378059387, 0.03559143841266632, 0.0892530232667923, -0.8559695482254028, 0.0631079375743866, 0.7256375551223755, -0.8078910708427429, -0.3406183421611786, 0.027925536036491394, 0.21745797991752625, 0.9310802221298218, -0.23049956560134888, -0.18948934972286224, -0.20172527432441711, -0.0991632342338562, -0.05078347772359848, -0.24059593677520752, -0.38294169306755066, 0.023695502430200577, 0.19600218534469604, -0.5511972904205322, -0.2931000590324402, 0.3386922776699066, 0.2459947168827057, -0.23138363659381866, 0.6573970317840576, 0.4763120710849762, 0.19984914362430573, 0.5644232630729675, 0.020173225551843643, -0.11180220544338226, -0.14226336777210236, -0.15130366384983063, 0.16892193257808685, -0.4342115819454193, 0.3310701549053192, -5.765457630157471, 0.3702239692211151, -0.3840848207473755, -0.16129718720912933, -0.34516099095344543, 0.21205559372901917, 1.2980046272277832, -0.2851780951023102, 0.3494494557380676, -0.0355190671980381, -0.2332506775856018, 0.5578516125679016, 0.385521799325943, -0.11356525123119354, 0.0828532949090004, 0.20690245926380157, 0.38228631019592285, -0.4165908396244049, 0.9817800521850586, 0.5863678455352783, 0.23687778413295746, -0.307146817445755, -0.1759372502565384, 0.42770788073539734, 0.29965487122535706, 0.553452730178833, -0.8152807354927063, 0.0762200802564621, -0.16210974752902985, -0.5118433833122253, 0.20967146754264832, -0.9600207805633545, -0.29293757677078247, -0.4643302261829376, 0.11731218546628952, -0.22303037345409393, 0.07232191413640976, 0.07613345980644226, -0.307747483253479, -0.3208010792732239, 0.08253591507673264, 0.16270610690116882, -0.2706027925014496, -0.18229912221431732, 0.2768019437789917, 0.49752384424209595, 0.022420646622776985, -0.01986180804669857, -0.3879666328430176, 0.8865987062454224, -0.032271742820739746, -0.276275634765625, 0.03867887333035469, 0.2658785581588745, 0.22303390502929688, 0.1215028315782547, -0.3423425555229187, 0.39117753505706787, -0.3115597367286682, 0.4452510178089142, 0.10914555191993713, -0.07602696865797043, -0.006799690425395966, -0.2080768197774887, -0.3261492848396301, 0.4711247384548187, -0.47392284870147705, -0.384653776884079, 0.06017570197582245, 0.023328818380832672, -0.346576988697052, 0.2505510449409485, 0.2344047576189041, -0.5701595544815063, 0.407423198223114, -0.26334986090660095, 0.0773000568151474, 0.18344230949878693, -0.14777399599552155, -0.267657607793808, -0.08570719510316849, -0.09632579982280731, 0.3234327733516693, -0.19394560158252716, 0.19414331018924713, -0.35025501251220703, -0.2092810869216919, -0.16732247173786163, -0.11577547341585159, -0.04866103082895279, -0.034993890672922134, -0.5497915148735046, 0.3058164119720459, 0.37147843837738037, 0.4569297730922699, 0.8170419931411743, 0.5075088739395142, 0.5398778915405273, 0.29951706528663635, 0.15374363958835602, 1.0739850997924805, -0.1058993935585022, -0.3094266653060913, -1.187105655670166, -0.09961659461259842, 0.06058109551668167, -0.30510076880455017, 0.05539828911423683, 0.4590907692909241, -0.7541369795799255, 0.32776907086372375, -0.19892773032188416, -0.561404287815094, -0.1647520214319229, 0.9791030287742615, -0.20731070637702942, 0.16836896538734436, -0.1764354556798935, 0.40837299823760986, -0.05097646266222, 0.17898494005203247, 0.1737367808818817, -0.5256884098052979, 0.49461886286735535, 0.27132856845855713, -0.962485671043396, 0.3878745138645172, 0.7015705108642578, -0.657994270324707, -0.0757703185081482, -0.00610887398943305, 0.7172127962112427, -0.09405145049095154, -0.16577741503715515, 0.02853134274482727, -0.5127955675125122, -0.2831825911998749, -0.14037835597991943, 0.5795080065727234, 0.1871696561574936, 0.013634767383337021, -0.07464822381734848, -0.29124245047569275, 0.44366970658302307, 0.4875764548778534, 0.025191817432641983, -0.11371271312236786, -0.05007796734571457, -0.14186935126781464, 0.10247920453548431, 0.1366027146577835, 0.14419996738433838, 0.38240623474121094, -0.07120154798030853, -0.3477427363395691, 0.11107676476240158, 0.8268282413482666, 0.10930082201957703, -0.10602676868438721, -0.8099878430366516, 0.5696344375610352, 0.022856242954730988, -1.0483086109161377, -0.06929247081279755, -0.16907203197479248, -0.44213905930519104, 0.10311755537986755, -0.4027171730995178, 0.27495068311691284, 0.2586838901042938, -0.45669910311698914, -0.4699361026287079, 0.441039115190506, 0.02362065576016903, 0.007266512606292963, -0.09432978183031082, -0.502318263053894, 0.167783722281456, -0.10757311433553696, 0.01270016748458147, 0.04623347520828247, -0.1774546056985855, -0.5080845952033997, 0.39297714829444885, 0.713013231754303, 0.8332512378692627, -0.06055730581283569, -0.07527091354131699, -0.406048059463501, -0.11179625988006592, 0.09360907226800919, -0.04354469105601311, 0.3297017514705658, -0.015036013908684254, -0.014777516014873981, -0.20685748755931854, 0.36281320452690125, 0.23349834978580475, -0.13982850313186646, -0.29290005564689636, 0.18410931527614594, 0.6783487200737, -0.17202694714069366, 0.4020208418369293, 0.378286749124527, -0.07609112560749054, -0.20069484412670135, 0.2135574221611023, -0.35307231545448303, -0.39948001503944397, -0.10478946566581726, -0.34116971492767334, -0.39235955476760864, 0.20080935955047607, -0.2702581584453583, 0.4721972942352295, 0.15718679130077362, -0.5863699316978455, -0.1268855780363083, 0.215139240026474, 0.2937428653240204, -0.31809002161026, -0.2717619836330414, -0.055553071200847626, -0.29423418641090393, 0.059475671499967575, 1.073991060256958, -0.872731626033783, 0.03657764941453934, 0.11817581951618195, -0.6413952708244324, 0.016807833686470985, 0.5163553357124329, 0.1914771944284439, -0.965997576713562, -0.0718546137213707, -0.2073982208967209, 0.013353179208934307, 0.38221246004104614, 0.45842498540878296, -0.2794964909553528, 0.3864407241344452, -0.21230751276016235, -0.6064876317977905, 0.15464796125888824, -0.0579952672123909, 0.6040523052215576, -0.4403891861438751, -0.2257562130689621, 0.039066363126039505, 0.2567026615142822, -0.7274382710456848, 0.28585106134414673, -0.02521016076207161, 0.7645966410636902, 0.16167382895946503, -0.24418112635612488, -0.7063004970550537, -0.10609651356935501, 0.08756399899721146, -0.3355378210544586, -0.2509627044200897, -0.5186985731124878, -0.025864863768219948, 0.12414278835058212, -0.12755697965621948, -0.33551058173179626, -0.2040032148361206, 0.1766737997531891, -0.4102102816104889, -0.14670397341251373, -0.16875126957893372, 0.5706902742385864, 0.44381701946258545, 0.08143950253725052, 0.18168799579143524, -0.6026054620742798, -0.12201319634914398, -0.5926958918571472, 0.23037898540496826, -0.7035773396492004, -0.5605536699295044, 0.5600837469100952, -0.2702653110027313, 0.05759839713573456, -0.3120858371257782, -0.10930415987968445, -0.19251465797424316, -0.2675354480743408, -0.17883311212062836, -0.06356089562177658, 0.07196151465177536, -0.5260611772537231, -0.3741110861301422, 0.10236451774835587, 0.1770971268415451, 0.25560203194618225, 0.13546302914619446, 0.21681083738803864, -0.3670155704021454, -0.35246169567108154, 0.7940145134925842, 0.1517021656036377, -0.31029146909713745, 0.2802298963069916, 0.007417852524667978, 0.40726542472839355, -0.020396919921040535, 0.006508482154458761, 0.16481193900108337, 0.3021627366542816, -0.00864323414862156, 0.15234725177288055, 0.005037388764321804, -0.5623453259468079, -0.0018029211787506938, -0.49612557888031006, -0.333530992269516, 0.7461269497871399, 0.20753198862075806, 0.42201465368270874, 1.0502994060516357, 0.9109508395195007, 0.19710002839565277, -0.7103400826454163, 0.7352630496025085, -0.027881421148777008, 0.3124117851257324, 0.14913755655288696, 0.13022896647453308, 0.2726787030696869, 0.5880178213119507, -0.36239320039749146, 0.20494456589221954, 0.1393701732158661, 0.45151785016059875, 0.049995057284832, -0.3030027151107788, -0.170712411403656, 0.11998748034238815, 0.8383994698524475, 0.23789185285568237, 0.026381872594356537, -0.008731143549084663, 0.14463607966899872, 0.36592555046081543, -0.2174208164215088, -0.006193913985043764, 0.028557978570461273, 0.22165903449058533, -0.008342086337506771, -0.24823901057243347, -0.4737985134124756, -0.050140563398599625, -0.062240537256002426, 0.48002663254737854, -0.07187491655349731, -0.4579388499259949, -1.1091787815093994, 0.2052583396434784, -0.4252173602581024, 0.27078476548194885, 0.1125500500202179, 0.8296767473220825, -0.35845664143562317, 0.09022685140371323, 0.21824142336845398, 0.13121886551380157, 0.1447868049144745, -0.392227441072464, 0.02565782330930233, -0.44422486424446106, -0.3892780542373657, 0.21782062947750092, 0.07117298990488052, -0.4900915324687958, -0.15696455538272858, -0.006507140584290028, 0.12085357308387756, 0.6163740158081055, -0.4058789014816284, 0.2835862338542938, -0.014531455002725124, -0.3923949599266052, 0.3448573052883148, -0.2900913953781128, -0.6034033894538879, 0.1316247582435608, 0.23901638388633728, 0.20390059053897858, 0.7077475190162659, -0.6641307473182678, 0.4408356249332428, 0.3254609704017639, -0.03839177265763283, -0.17597121000289917, 0.15812870860099792, 0.592431902885437, 0.12126024812459946, -0.18990680575370789, -0.3599357306957245, 0.14343881607055664, -0.3673592507839203, 0.7836713790893555, -0.27789899706840515, 0.3901002109050751, -0.9205971360206604, -0.47888749837875366, -0.7582410573959351, 0.3801273703575134, 0.7093749642372131, 0.2833079397678375, -0.4203208386898041, 0.30847400426864624, 0.2741546332836151, 0.1039806380867958, 0.46013253927230835, -0.32790398597717285, -0.29961520433425903, -0.5970159769058228, -0.44040048122406006, -0.6656018495559692, 0.4713793098926544, -0.10334700345993042, -0.34026819467544556, 0.17709922790527344, 0.2639157772064209, 0.390874981880188, -0.16378088295459747, 0.09424047917127609, -0.328731894493103, -0.09708631783723831, -0.6945457458496094, 0.45385032892227173, -0.45898523926734924, 0.5049133896827698, 0.4767417907714844, 0.24456310272216797, 0.2640506625175476, -0.04869943857192993, -0.06091317906975746, -0.2911019027233124, 0.03217058256268501, -0.37117233872413635, 0.14998194575309753, 0.31934502720832825, 0.22036483883857727, -0.7548546195030212, -0.8580242395401001, 0.45604345202445984, -0.16518501937389374, -0.6232702136039734, -0.23503835499286652, 0.3398069739341736, -0.45088207721710205, -0.18025557696819305, 0.09784021228551865, -0.27098551392555237, 0.0738578662276268, -0.7731111645698547 ]
BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We analysed the interaction between human population density and lack of tap water as a cause of dengue fever outbreaks with the aim of identifying geographic areas at highest risk. METHODS AND FINDINGS We conducted an individual-level cohort study in a population of 75,000 geo-referenced households in Vietnam over the course of two epidemics, on the basis of dengue hospital admissions (n = 3,013). We applied space-time scan statistics and mathematical models to confirm the findings. We identified a surprisingly narrow range of critical human population densities between around 3,000 to 7,000 people/km² prone to dengue outbreaks. In the study area, this population density was typical of villages and some peri-urban areas. Scan statistics showed that areas with a high population density or adequate water supply did not experience severe outbreaks. The risk of dengue was higher in rural than in urban areas, largely explained by lack of piped water supply, and in human population densities more often falling within the critical range. Mathematical modeling suggests that simple assumptions regarding area-level vector/host ratios may explain the occurrence of outbreaks. CONCLUSIONS Rural areas may contribute at least as much to the dissemination of dengue fever as cities. Improving water supply and vector control in areas with a human population density critical for dengue transmission could increase the efficiency of control efforts. Please see later in the article for the Editors' Summary.
[ -0.010861074551939964, 0.01695527695119381, -0.0056493813171982765, 0.01557481661438942, -0.02896900102496147, -0.026597188785672188, 0.009669620543718338, 0.018407007679343224, -0.017833396792411804, -0.02480389177799225, 0.003265730571001768, 0.024866078048944473, -0.01938866265118122, 0.022072777152061462, -0.013821504078805447, 0.005043811164796352, 0.006779646035283804, 0.006238487083464861, 0.008375248871743679, -0.011193979531526566, 0.0032833542209118605, -0.011835748329758644, 0.010293546132743359, -0.02031935751438141, -0.01607457920908928, 0.017881810665130615, 0.01013134978711605, -0.03374822810292244, 0.0018504727631807327, -0.004496932029724121, 0.027870535850524902, 0.028532201424241066, -0.019334109500050545, 0.009600043296813965, 0.012911781668663025, -0.0037805656902492046, -0.0006258695502765477, 0.02938997559249401, -0.006333835422992706, -0.004272381775081158, 0.01558045856654644, -0.01192726381123066, 0.00010894995648413897, -0.017901362851262093, -0.007374520879238844, 0.006930158007889986, -0.0065401215106248856, -0.02628232352435589, -0.009368283674120903, 0.003896735142916441, -0.006264518015086651, -0.009875711984932423, -0.0076847863383591175, -0.0051191202364861965, -0.0069719841703772545, 0.011763856746256351, 0.018989935517311096, 0.009397138841450214, -0.011482656002044678, 0.02308492362499237, -0.016205860301852226, -0.025203194469213486, -0.012504134327173233, 0.0025259689427912235, 0.037393901497125626, -0.0669173076748848, -0.02382228896021843, -0.020305518060922623, 0.028073038905858994, -0.029483353719115257, 0.025069762021303177, 0.0014004481490701437, -0.0028021237812936306, 0.006200889125466347, -0.0006122183986008167, -0.014973903074860573, 0.009975768625736237, 0.0048391628079116344, 0.02701464667916298, 0.002926628105342388, 0.020289314910769463, -0.007525451947003603, 0.007278816774487495, 0.022582512348890305, -0.009867677465081215, 0.00924590788781643, -0.003443037159740925, 0.013534925878047943, -0.015050691552460194, -0.019671790301799774, -0.006343920715153217, -0.01362975686788559, 0.00022615853231400251, 0.012565819546580315, 0.004500154871493578, 0.0031312780920416117, 0.002776606474071741, -0.008148221299052238, 0.00953640416264534, -0.007324183359742165, 0.009093699976801872, -0.0051701790653169155, 0.022502414882183075, 0.027116360142827034, 0.008635368198156357, 0.016650859266519547, -0.03341614827513695, -0.017686832696199417, 0.014998853206634521, 0.0058063725009560585, -0.009347098879516125, -0.00025296135572716594, 0.01117104385048151, 0.0066428035497665405, -0.008549688383936882, -0.01676958240568638, -0.008254460990428925, 0.013432390987873077, 0.007430619560182095, 0.009094382636249065, 0.01642770506441593, -0.013059930875897408, -0.00803972315043211, 0.01232010405510664, -0.0017124763689935207, 0.0004883534274995327, -0.010968269780278206, 0.0008805254474282265, -0.00097655039280653, -0.014306707307696342, -0.007386797107756138, -0.002551120240241289, 0.011402259580790997, -0.012001559138298035, 0.00213366630487144, 0.015712393447756767, -0.005910906940698624, -0.004260390065610409, -0.006918999832123518, 0.01358901709318161, 0.004868816584348679, 0.008793455548584461, 0.00019648991292342544, 0.00958729162812233, -0.018457666039466858, 0.0024925624020397663, -0.018944762647151947, 0.019388355314731598, 0.009183699265122414, 0.023745104670524597, 0.0023286156356334686, -0.009048928506672382, 0.011400282382965088, -0.0212717242538929, -0.04559144377708435, 0.023207232356071472, -0.010258784517645836, 0.004663393832743168, -0.001027537859044969, 0.04584108293056488, 0.00041205715388059616, -0.004710674751549959, 0.002309120027348399, 0.009925827383995056, -0.006812701001763344, 0.012351499870419502, -0.001834573457017541, -0.006929138675332069, -0.00628680968657136, 0.004881029017269611, -0.0005949855549260974, -0.01299775019288063, -0.01311233825981617, 0.011659622192382812, 0.013593419454991817, -0.007681667804718018, 0.03743072599172592, 0.009305327199399471, -0.0034677900839596987, 0.0665656179189682, -0.0260777585208416, -0.03867368400096893, -0.025760991498827934, 0.024837665259838104, 0.00039865216240286827, 0.006822807714343071, 0.047944068908691406, -0.010541101917624474, 0.01120050624012947, -0.009280407801270485, -0.02328701689839363, 0.0007741195149719715, 0.028879206627607346, -0.025713682174682617, -0.029756642878055573, 0.0038431622087955475, 0.0170183926820755, 0.0019749286584556103, -0.00900456216186285, 0.03288194537162781, 0.006313636898994446, 0.004327008500695229, 0.015536878257989883, -0.015244374983012676, -0.03716445714235306, 0.018671661615371704, 0.03976980969309807, 0.012157161720097065, 0.003043757751584053, -0.008586697280406952, 0.008472017012536526, 0.023233313113451004, 0.012528806924819946, 0.002816505264490843, -0.002452850341796875, 0.00227815518155694, -0.005210083909332752, 0.008959486149251461, -0.024577006697654724, -0.016291065141558647, -0.006018669344484806, -0.006166962906718254, -0.027660690248012543, 0.018626201897859573, 0.005553708411753178, 0.013636071234941483, -0.005381867755204439, 0.01048673503100872, -0.023624727502465248, 0.0030688773840665817, -0.016230249777436256, -0.010952567681670189, -0.010099157691001892, 0.019689075648784637, 0.0117800273001194, -0.0030722918454557657, 0.012807775288820267, -0.016366317868232727, 0.007140678353607655, -0.013445570133626461, 0.0027897502295672894, -0.027408137917518616, -0.0034498777240514755, 0.0146099291741848, -0.0014192028902471066, -0.018243487924337387, 0.021331440657377243, -0.0009245220571756363, -0.014796946197748184, -0.006926636211574078, 0.0092081930488348, 0.003026382066309452, 0.02541709691286087, 0.020789045840501785, 0.034918755292892456, -0.01643756404519081, 0.0029415213502943516, -0.008506188169121742, 0.024853795766830444, -0.00927035789936781, 0.015205238945782185, 0.004555598832666874, -0.0148243997246027, -0.01095450110733509, 0.03866930305957794, -0.004825951531529427, -0.003965278156101704, 0.021682798862457275, 0.005345424637198448, 0.014375370927155018, 0.006138837430626154, -0.009601231664419174, -0.0012718973448500037, -0.08138337731361389, -0.0061817411333322525, 0.005204679444432259, -0.028179120272397995, 0.006602591369301081, 0.005848540458828211, 0.014783382415771484, -0.0004473309963941574, 0.009741097688674927, 0.008665220811963081, 0.014336139895021915, 0.02508832886815071, 0.0001439800253137946, -0.008921471424400806, -0.01774599775671959, -0.004905166104435921, 0.006706195883452892, 0.04085282236337662, -0.018557749688625336, -0.01646502874791622, -0.00040637014899402857, 0.017625944688916206, 0.025643885135650635, -0.02753039449453354, -0.00299058947712183, 0.007868480868637562, 0.03679230809211731, 0.011519375257194042, -0.006656600162386894, 0.009023085236549377, -0.002135068876668811, -0.005273864138871431, 0.011698879301548004, -0.02678855136036873, 0.03938399627804756, -0.0019806954078376293, 0.0005748573457822204, -0.008551565930247307, -0.01798996329307556, 0.012182919308543205, 0.009388389997184277, 0.01801428571343422, 0.001471195137128234, 0.008226990699768066, 0.02047385647892952, -0.004049196839332581, 0.003086515236645937, -0.002864057896658778, 0.016316872090101242, -0.0004886677488684654, -0.020524930208921432, -0.016894005239009857, 0.03077651932835579, 0.008056465536355972, -0.004550204146653414, -0.04144936800003052, 0.0025736435782164335, 0.0026905699633061886, -0.010127940215170383, -0.01624993048608303, -0.031365834176540375, 0.024245986714959145, -0.032708387821912766, 0.002077751327306032, -0.03588161990046501, -0.013101554475724697, 0.030438516288995743, 0.010207433253526688, -0.011379973962903023, 0.013950690627098083, 0.009965186007320881, 0.022620420902967453, 0.013675468973815441, -0.012233931571245193, 0.023173976689577103, 0.0013153180480003357, -0.016339421272277832, 0.002613841323181987, 0.009440627880394459, -0.0004889224655926228, -0.014933135360479355, 0.005244823172688484, -0.02277221903204918, 0.010370645672082901, -0.0032496899366378784, -0.009101688861846924, 0.016813205555081367, 0.03274073824286461, 0.015904109925031662, -0.015624294057488441, 0.0315779373049736, 0.00478134211152792, 0.0020730658434331417, 0.010067896917462349, -0.05349761247634888, 0.02600681409239769, 0.01072619017213583, -0.011017834767699242, 0.007477369625121355, 0.00834396667778492, 0.03998580202460289, -0.0048478227108716965, 0.004679708741605282, -0.011815209873020649, 0.009250563569366932, 0.013131482526659966, 0.017148872837424278, -0.0034118674229830503, 0.00016762525774538517, -0.007961300201714039, -0.0008989942725747824, 0.006186855025589466, -0.005047468468546867, -0.021783197298645973, 0.015526145696640015, -0.026234161108732224, 0.009290408343076706, -0.014818023890256882, 0.0717097744345665, -0.012046368792653084, 0.011161080561578274, -0.01705794595181942, -0.001086027710698545, 0.007144995499402285, 0.010039709508419037, -0.017966175451874733, -0.003190344199538231, -0.025487426668405533, 0.013562497682869434, -0.02627743035554886, 0.00232228497043252, -0.012782390229403973, -0.014369716867804527, -0.004782253876328468, 0.014029286801815033, 0.0017284713685512543, 0.008749900385737419, -0.01989518478512764, 0.009614494629204273, -0.004621047060936689, -0.0028985044918954372, 0.036687448620796204, -0.016116468235850334, 0.045241210609674454, -0.032341618090867996, -0.015357067808508873, -0.028038475662469864, 0.0000408054911531508, 0.01084743719547987, 0.02859717234969139, -0.002920290920883417, -0.017994312569499016, -0.0014159372076392174, -0.0037748198956251144, 0.0013181900139898062, -0.00769133772701025, 0.01666298508644104, -0.024269048124551773, 0.007639916613698006, -0.00776666821911931, -0.0083744116127491, 0.011578237637877464, -0.007537022698670626, 0.025004515424370766, 0.0067533766850829124, -0.0062185595743358135, -0.019129902124404907, 0.00600544223561883, 0.009295507334172726, 0.029447041451931, 0.0055321455001831055, -0.01714904233813286, -0.0040420410223305225, 0.021200086921453476, -0.010095689445734024, 0.008501609787344933, 0.009440344758331776, 0.020361170172691345, -0.004065296147018671, -0.01030051801353693, -0.0068726735189557076, -0.011171157471835613, -0.0077391983941197395, -0.007096223533153534, -0.001730053685605526, 0.00945283006876707, -0.02228458784520626, 0.016846822574734688, -0.008638769388198853, -0.0017746386583894491, 0.02473563887178898, -0.01859528385102749, -0.025470569729804993, 0.016729651018977165, -0.015019276179373264, 0.0157760139554739, -0.004924936220049858, 0.005314328242093325, -0.012256382964551449, 0.013492882251739502, 0.03074389137327671, -0.004602667409926653, 0.01647600159049034, 0.018301673233509064, -0.015213683247566223, -0.07434633374214172, 0.001122061163187027, 0.01580849289894104, -0.008258103393018246, 0.002743462333455682, 0.018344201147556305, -0.018830258399248123, 0.009420226328074932, -0.029293466359376907, -0.015470894053578377, -0.021596495062112808, -0.021395456045866013, 0.01913975551724434, 0.0079074427485466, 0.01643068715929985, 0.025477077811956406, -0.02785457670688629, 0.0007345086196437478, -0.01424144022166729, 0.01191723346710205, 0.04948369041085243, -0.0016609419835731387, -0.029067108407616615, 0.012609705328941345, 0.011814910918474197, -0.08071654289960861, -0.008996432647109032, 0.021021351218223572, 0.008156761527061462, 0.008348790928721428, -0.01280248537659645, -0.0017333406722173095, -0.017389772459864616, 0.002786169294267893, -0.01651795208454132, 0.012973254546523094, -0.015375515446066856, 0.0345587357878685, 0.001938928384333849, -0.027852440252900124, -0.007571741472929716, 0.006685518193989992, -0.014456374570727348, -0.03635069355368614, 0.01286904327571392, -0.0077584004029631615, -0.005351100582629442, -0.008540972135961056, -0.011095020920038223, -0.005090472288429737, -0.015693727880716324, 0.00011373218148946762, 0.003115531988441944, 0.02150006592273712, 0.002503149677067995, 0.013014963828027248, 0.010315671563148499, -0.003038430120795965, -0.02437012642621994, 0.026376517489552498, -0.014606621116399765, 0.017450209707021713, 0.012657076120376587, 0.028718363493680954, 0.011456841602921486, -0.004784531891345978, 0.010523050092160702, 0.019542671740055084, -0.006670806556940079, -0.0008825275581330061, -0.019039008766412735, 0.008398430421948433, -0.018148204311728477, 0.02990601770579815, -0.025855980813503265, 0.005768493749201298, -0.03612178936600685, 0.03864051401615143, 0.0017167115584015846, 0.017238643020391464, -0.008986806496977806, -0.00857626087963581, 0.006452511064708233, 0.006582740694284439, 0.016376759856939316, -0.0042444756254553795, 0.012653041630983353, -0.005461151711642742, 0.07143654674291611, -0.046012163162231445, -0.013950226828455925, -0.010978246107697487, -0.013563846237957478, 0.000733661581762135, -0.024447064846754074, -0.0024774435441941023, -0.004755661357194185, -0.009839221835136414, -0.0004447565879672766, -0.004747550003230572, -0.0062531582079827785, 0.007252370938658714, -0.004238124471157789, 0.02826104685664177, 0.005607753060758114, 0.010668214410543442, -0.020356295630335808, -0.021666143089532852, -0.012606806121766567, 0.00007787533104419708, -0.04031671583652496, -0.0028054455760866404, 0.025106288492679596, 0.005690939724445343, 0.00822548195719719, -0.002598460763692856, -0.031079109758138657, 0.007450162898749113, -0.007737129461020231, 0.006769414991140366, 0.005510900169610977, -0.03174440562725067, 0.0019738152623176575, -0.002424891572445631, 0.008203886449337006, 0.004547093063592911, -0.003186870366334915, 0.018612470477819443, -0.02172362245619297, 0.012256918475031853, 0.0021044835448265076, -0.003969078883528709, 0.009662449359893799, -0.017611337825655937, -0.010100441984832287, 0.017553094774484634, -0.0013666730374097824, 0.018804427236318588, 0.006507483776658773, 0.008808396756649017, -0.00010260962881147861, 0.009816750884056091, 0.006633326411247253, -0.009352052584290504, 0.009822649881243706, 0.020445792004466057, 0.0022040423937141895, -0.002663393970578909, 0.004624484106898308, -0.014142733067274094, -0.02573213540017605, -0.019954506307840347, 0.0018321494571864605, -0.02745196595788002, 0.0009880042634904385, -0.008900094777345657, -0.005370322614908218, 0.008191190659999847, -0.0018837443785741925, 0.019604172557592392, 0.0073037464171648026, 0.0018651590216904879, 0.011320355348289013, -0.004567980766296387, 0.024807214736938477, 0.013537523336708546, 0.006800754927098751, 0.0214284285902977, -0.007042714860290289, -0.01753350719809532, 0.022087635472416878, 0.02032935619354248, -0.0069203912280499935, -0.01973073184490204, 0.006467009894549847, -0.010265275835990906, -0.012084970250725746, 0.004099199548363686, -0.03555843234062195, 0.009393302723765373, 0.002939559519290924, 0.011764372698962688, 0.015201057307422161, 0.035230472683906555, -0.005693983286619186, 0.008143049664795399, -0.0010611889883875847, 0.0018580268369987607, 0.026618152856826782, -0.006778334267437458, -0.014587657526135445, 0.01009889505803585, 0.007373161613941193, -0.0015025932807475328, 0.01458534225821495, -0.005317585077136755, 0.017516395077109337, -0.0072630224749445915, -0.000018388032913208008, 0.013150777667760849, 0.018850695341825485, -0.02029336802661419, 0.0001469185808673501, 0.008521312847733498, -0.013309784233570099, -0.008487123064696789, 0.03038414940237999, -0.011513611301779747, -0.014177522622048855, -0.005335909314453602, 0.024341337382793427, 0.022748470306396484, -0.01220161747187376, -0.023976385593414307, -0.01211419329047203, -0.04780380055308342, 0.014395123347640038, 0.019612204283475876, 0.016620172187685966, 0.0029331303667277098, -0.003811076283454895, 0.02513405680656433, 0.004289668053388596, 0.002977811498567462, 0.0344962477684021, -0.004284486640244722, -0.0027907351031899452, 0.017567167058587074, 0.01565638743340969, -0.014111070893704891, 0.004317891784012318, 0.0020842906087636948, 0.00860537774860859, 0.016436826437711716, -0.005710058845579624, 0.009144711308181286, 0.024309925734996796, -0.0034915811847895384, -0.01054295338690281, 0.015174593776464462, 0.014941439032554626, -0.005883991718292236, 0.024254364892840385, 0.0021609284449368715, 0.031910575926303864, -0.027407603338360786, 0.0018001925200223923, 0.004229385871440172, 0.0014241188764572144, 0.017248760908842087, 0.0038063691463321447, -0.000693353358656168, 0.013937240466475487, 0.0025028130039572716, 0.005710321478545666, -0.012832093052566051, -0.009331375360488892, 0.031164882704615593, -0.029827896505594254, -0.00759633956477046, 0.0012236468028277159, -0.008449792861938477, -0.04575581103563309, -0.006855981424450874, 0.030169233679771423, 0.005238356534391642, -0.014840622432529926, 0.01104065589606762, -0.0030856523662805557, 0.009281282313168049, 0.005320059135556221, -0.0044893971644341946, 0.004352102521806955, -0.0062173050828278065, -0.01261914148926735, 0.008239027112722397, 0.010620757937431335, 0.015238847583532333, -0.0020712553523480892, -0.020185410976409912, -0.003096655709668994, -0.017906248569488525, -0.01897704228758812, -0.003970900550484657, -0.016032323241233826, -0.020334213972091675, 0.009994098916649818, 0.02356584370136261, 0.02481059916317463, 0.012993918731808662 ]
[ 0.7188229560852051, 0.07816296815872192, -0.5409696698188782, 0.04538583382964134, -0.027057018131017685, 0.8107722997665405, 0.40948230028152466, 0.3325616121292114, -0.5787013173103333, -0.5426453948020935, 0.0889081358909607, -0.2304224669933319, -0.48614877462387085, 0.00617316784337163, -0.27840596437454224, 0.7962706089019775, 0.5867160558700562, 0.38140571117401123, -0.21723565459251404, -0.29895883798599243, -0.5948019027709961, -0.43104127049446106, 0.19454985857009888, 0.09213929623365402, -0.20308248698711395, -0.12355820834636688, 0.24397175014019012, 0.4040682017803192, 0.49117353558540344, -0.40515974164009094, 0.13052943348884583, 0.7314485907554626, 0.2829204797744751, -0.09192733466625214, -0.007225842215120792, -0.4496723711490631, -0.0917426347732544, 0.12617497146129608, 0.22907422482967377, -0.35034212470054626, -0.18060581386089325, -0.17858314514160156, -0.21272540092468262, 0.2684645652770996, -0.215581476688385, -0.6053286790847778, -1.1017986536026, 0.8736782670021057, -0.4543238878250122, 0.019799156114459038, 0.12169675529003143, 0.3460533320903778, 0.19159485399723053, -0.035412777215242386, -0.03576841950416565, 0.2758067548274994, -0.6173266172409058, -0.019193291664123535, 0.4690890908241272, -0.42983609437942505, 0.025983450934290886, -0.3543272614479065, -0.2250545620918274, 0.05969427898526192, -0.6494486331939697, 0.6673808097839355, 0.05082397907972336, 0.377678781747818, 0.23589497804641724, -0.31981581449508667, 0.12833066284656525, -0.18733419477939606, -0.3487895727157593, 0.30949103832244873, -0.3156262934207916, 0.3621845543384552, -0.13539475202560425, -0.21198764443397522, 0.26146626472473145, -0.005248677916824818, 0.09659935534000397, -0.0768207237124443, 0.44016796350479126, -0.5499258637428284, 0.629902720451355, 0.4518650770187378, 0.2221652865409851, 0.4878465533256531, 0.061612628400325775, -0.37199944257736206, -0.09042280167341232, -0.08065653592348099, 0.06357645988464355, 0.652604341506958, -0.5659269094467163, 0.4975097179412842, -0.004822536371648312, -0.08186232298612595, 0.6986539363861084, 0.14754679799079895, -0.5511118173599243, -0.14686572551727295, 0.11366686969995499, -0.11631740629673004, -0.3884604573249817, 0.16620656847953796, -0.2683369517326355, -0.17004606127738953, -1.0159941911697388, -0.02087540365755558, -0.4750521779060364, 0.08130890130996704, -0.2955959439277649, -0.329205721616745, -0.10622985661029816, 0.10754288733005524, 0.2508721351623535, -0.5838099718093872, -0.04998069256544113, 0.04044258967041969, -0.4289553165435791, 0.7368914484977722, -0.21694058179855347, 0.6497229933738708, -0.2398473620414734, 0.34859979152679443, 0.231148362159729, 0.07741651684045792, -0.20276562869548798, 0.6821753978729248, 0.4318843483924866, 0.5238054394721985, -0.24742577970027924, 0.24916525185108185, 0.2525336742401123, -0.22361664474010468, -0.264766663312912, 0.7244563698768616, 0.5274799466133118, 0.289773553609848, -0.8036978244781494, -0.5350786447525024, -0.2333710789680481, 0.2525845766067505, -0.30424028635025024, -0.29679781198501587, -0.12151964008808136, -0.46729111671447754, 0.34714916348457336, -0.19315625727176666, 0.20260903239250183, 0.04369267448782921, -0.43904948234558105, -0.10563860088586807, -0.29708901047706604, 0.1020197793841362, -0.13366740942001343, -0.19025957584381104, 0.07524274289608002, 0.3487299382686615, 0.46994832158088684, 0.5630753040313721, -0.30729442834854126, -0.09208463877439499, 0.39691877365112305, -0.09587931632995605, -0.2737807035446167, 0.2127515822649002, -0.3153636157512665, 0.3426019549369812, -0.3969396948814392, -0.3769848048686981, -0.24165436625480652, -0.25412705540657043, -0.14105339348316193, 0.02966177649796009, -0.15609842538833618, -0.13911794126033783, 0.4801473915576935, 0.2016245722770691, -0.6154673099517822, 0.3050853908061981, 0.044158924371004105, -0.480643093585968, 0.3345282971858978, 0.11354859173297882, 0.05637185648083687, 0.028652772307395935, 0.046597786247730255, -0.21993790566921234, -0.4435655474662781, -0.4574948847293854, 0.5473798513412476, -0.3426492214202881, 0.9847010970115662, -0.3488025367259979, -0.25951525568962097, 0.9956068396568298, 0.6075586080551147, -0.21975961327552795, 0.10874331742525101, 0.020917626097798347, 0.5845749974250793, -0.07906962931156158, -1.3573753833770752, -0.11236494779586792, -0.1885334998369217, -0.3630567193031311, -0.08970899134874344, -0.26447826623916626, 0.2911870777606964, -0.1928078979253769, -0.3527199625968933, -0.3109729588031769, 0.3485376536846161, 0.32789772748947144, -0.44719433784484863, -0.2424536943435669, 0.33082181215286255, -0.044061146676540375, 0.24996796250343323, -0.9222893714904785, 0.40850576758384705, 0.3980925977230072, -0.0918518677353859, 0.4925647974014282, 0.7565823197364807, -0.11472943425178528, 1.059596061706543, -1.1438775062561035, 0.235184445977211, 0.13990120589733124, 0.054970357567071915, -1.1589640378952026, -0.3111828565597534, -0.054999981075525284, -0.05257159098982811, -0.15331123769283295, -0.10155712068080902, 0.2844533622264862, -0.009009580127894878, 0.35090896487236023, -0.748530387878418, -0.010068471543490887, 0.052759815007448196, -0.8236338496208191, -0.27193763852119446, -0.10174519568681717, -0.7968881130218506, 0.01896759122610092, 0.06349585205316544, 0.31357309222221375, 0.36528584361076355, -0.7322697043418884, -0.3079306483268738, 0.23017600178718567, 0.18767352402210236, -0.46092215180397034, 0.4789430499076843, -0.40441030263900757, -0.45324283838272095, 0.2369452565908432, 0.25457441806793213, 0.3666577935218811, 0.4575873017311096, -0.5277131199836731, -0.5480854511260986, -0.6797440052032471, 0.44101205468177795, 0.22371050715446472, 0.8008297085762024, 0.18011464178562164, -0.2834869921207428, -0.21525675058364868, 0.057913970202207565, -0.6745664477348328, 0.13382288813591003, 0.808725118637085, -0.8569643497467041, -0.4645453095436096, -0.16776233911514282, 0.2808351516723633, 0.4071653187274933, -0.6079661250114441, 0.2353052943944931, -0.2579440474510193, 0.06799457222223282, -0.13562439382076263, -0.72412109375, -0.13747525215148926, 0.04652924835681915, 0.1232488602399826, -0.10881992429494858, 0.2726456820964813, 0.26567986607551575, 0.2390139102935791, -0.13309454917907715, 0.43407338857650757, 0.8421314358711243, -0.33225399255752563, 0.1025325208902359, 0.34328794479370117, -0.2578854560852051, 0.1430910974740982, -0.2772413492202759, -0.11756598949432373, -0.11183249950408936, 0.23994794487953186, -5.841442108154297, 0.34328868985176086, 0.17237462103366852, -0.19115352630615234, -0.47015783190727234, 0.2558046877384186, 1.2078068256378174, -0.0026220264844596386, 0.5618160963058472, 0.055728573352098465, 0.6296213865280151, 0.2882353365421295, 0.005659927148371935, 0.013775226660072803, -0.013594424352049828, 0.13109540939331055, 0.17316389083862305, -0.2645232379436493, 0.5054371953010559, 0.3826480805873871, -0.11195613443851471, -0.04712935537099838, 0.009104790166020393, 0.38345658779144287, 0.2895500957965851, 0.060365255922079086, -0.81386798620224, 0.04118632525205612, -0.250910222530365, -0.23450151085853577, 0.30276617407798767, -1.088154673576355, 0.09320149570703506, 0.07735839486122131, -0.18412914872169495, -0.03455739468336105, 0.021417180076241493, -0.22077246010303497, -0.5306136608123779, -0.2291259616613388, -0.3396742343902588, -0.2321540266275406, -0.036441314965486526, -0.026907239109277725, 0.1325971931219101, -0.07474876195192337, 0.1544700711965561, -0.32449421286582947, 0.09040471166372299, 1.1893095970153809, -0.18583634495735168, 0.009105155244469643, 0.36942312121391296, 0.7051861882209778, 0.06588225066661835, 0.18349233269691467, -0.03610089793801308, 0.4304293394088745, -0.03268740698695183, 0.20862124860286713, 0.06560570001602173, -0.031114332377910614, 0.06289336085319519, -0.49684658646583557, 0.4306945204734802, 0.16212092339992523, -0.7686871290206909, 0.07635661959648132, 0.0755709856748581, -0.4707179069519043, -0.3649168908596039, 0.09361489862203598, 0.2727426588535309, -0.8915701508522034, 0.12934480607509613, -0.8221583962440491, -0.19067761301994324, -0.2302682250738144, 0.34082114696502686, -0.5483360290527344, -0.33494508266448975, -0.15100795030593872, 0.2131376564502716, -0.15182484686374664, 0.27174943685531616, -0.21128308773040771, -0.14791269600391388, -0.3191016614437103, 0.2937459349632263, -0.07278876006603241, 0.6299270391464233, -0.22724348306655884, 0.3241835832595825, 0.17221254110336304, 0.7530675530433655, 1.266371488571167, 0.5820830464363098, -0.028388619422912598, 0.7316867709159851, 0.10668860375881195, 0.7709334492683411, -0.4043446183204651, -0.3833131790161133, -0.7805523872375488, 0.41050437092781067, -0.20053143799304962, -0.14184336364269257, 0.19971874356269836, 0.5039401650428772, -0.665128767490387, 0.4746565520763397, -0.1016513779759407, -0.22366046905517578, -0.06345700472593307, 0.4600984752178192, 0.19864363968372345, 0.7230907082557678, 0.22280064225196838, 0.9735713005065918, -0.2407619059085846, 0.41784289479255676, 0.4202657639980316, -0.09715953469276428, 0.4466271698474884, 0.39035770297050476, -0.4482516944408417, 0.11172989755868912, 0.49151936173439026, -0.6011523604393005, -0.42523449659347534, -0.172879159450531, 0.2617053985595703, -0.049741875380277634, -0.3001556992530823, -0.03705204278230667, -0.19872961938381195, 0.013124251738190651, -0.2970413565635681, 0.34110021591186523, 0.15243402123451233, -0.14713896811008453, 0.08748601377010345, -0.3802407383918762, 0.38460689783096313, 0.400712251663208, -0.25527894496917725, -0.18577887117862701, -0.1622696816921234, 0.09338933229446411, -0.3285061717033386, 0.44092223048210144, -0.14064346253871918, 0.5587750673294067, 0.29803428053855896, -0.8117181062698364, 0.08920284360647202, 0.6467598080635071, 0.12562017142772675, -0.0988142117857933, -0.5267096161842346, 0.5247262120246887, -0.3019494116306305, -1.1883317232131958, -0.11324009299278259, 0.10001673549413681, -0.35109567642211914, 0.47106990218162537, -0.7068920135498047, 0.07496435195207596, 0.3353106379508972, 0.0912075787782669, 0.01423623040318489, 0.1209237203001976, 0.47985517978668213, -0.07185244560241699, -0.15108631551265717, -0.7033215761184692, 0.13272495567798615, -0.011286440305411816, 0.196109339594841, -0.1583404392004013, 0.31103086471557617, -0.6907801032066345, 0.4582565128803253, 0.7072809338569641, 0.8886390328407288, -0.001857650582678616, -0.16664433479309082, -0.6066275238990784, -0.21723836660385132, 0.3657064139842987, -0.10012224316596985, 0.48751240968704224, 0.28471097350120544, 0.22214622795581818, -0.10033953189849854, -0.05161525309085846, 0.10671483725309372, -0.3837241530418396, -0.269581139087677, -0.4687008857727051, 0.7350631356239319, -0.47108855843544006, 0.34014323353767395, 0.09628807753324509, -0.15849807858467102, 0.453666090965271, -0.20295913517475128, -0.11196587979793549, -0.6753568053245544, -0.12456720322370529, -0.03987027704715729, -0.49834316968917847, 0.5927665829658508, -0.6005338430404663, 0.1423511654138565, -0.13325287401676178, -0.43071404099464417, -0.024859588593244553, 0.3403041660785675, 0.06387320160865784, 0.060182902961969376, 0.008951916359364986, -0.38713088631629944, -0.12285082787275314, 0.3918166756629944, 0.6534386873245239, -0.8631582856178284, -0.0858972892165184, 0.3872697353363037, -0.5294139385223389, 0.020128581672906876, 0.6630883812904358, 0.12261350452899933, -0.8825007677078247, -0.1816529482603073, 0.410341739654541, -0.17365939915180206, 0.43373793363571167, 0.5342093706130981, -0.15224136412143707, 0.34021052718162537, -0.48906776309013367, -0.402583509683609, 0.10421029478311539, 0.22385483980178833, 0.2978406250476837, -0.4094274640083313, -0.35482144355773926, 0.08849495649337769, 0.23898516595363617, -0.18763992190361023, 0.027699679136276245, 0.05773639306426048, 0.3470083773136139, -0.005415234714746475, -0.36447250843048096, -0.3120439946651459, 0.06043069437146187, -0.10211467742919922, -0.1951064020395279, -0.6598811745643616, -0.08510722219944, -0.1801442801952362, -0.2577711343765259, -0.3037396967411041, -0.19988177716732025, 0.19052176177501678, 0.11159267276525497, -0.48431357741355896, -0.15249453485012054, -0.18910756707191467, 0.5531939268112183, 0.4543082118034363, 0.0910850539803505, 0.16679240763187408, -0.5325778722763062, -0.017953388392925262, -0.1880410760641098, 0.4690901041030884, -0.5447697043418884, -0.8064273595809937, 0.08756956458091736, 0.004095582757145166, 0.23045508563518524, -0.1320507675409317, 0.09401565045118332, -0.2904663681983948, 0.09670086205005646, -0.5383724570274353, -0.1946016252040863, -0.17683649063110352, -0.11879017949104309, -0.41065144538879395, 0.4690728187561035, 0.23516511917114258, 0.47141528129577637, 0.3312074840068817, 0.17764504253864288, -0.3964557945728302, -0.8353009819984436, 0.5692561864852905, 0.45587509870529175, -0.49847760796546936, 0.3355845510959625, -0.20314213633537292, 0.32356199622154236, -0.04621640592813492, -0.062296006828546524, 0.2512519061565399, 0.4092482328414917, -0.13775409758090973, 0.2908925414085388, 0.14498458802700043, -0.30513525009155273, 0.2726050019264221, -0.2889195382595062, -0.7431997656822205, 0.6163204312324524, -0.06570548564195633, 0.29405468702316284, 0.6053603887557983, 0.35036715865135193, 0.2648380398750305, 0.014385337010025978, 0.7464370131492615, -0.44995173811912537, 0.3389267325401306, 0.2157118320465088, 0.2672397196292877, 0.3042432367801666, 0.12367628514766693, -0.5146510004997253, -0.00846029631793499, -0.09195299446582794, 0.6251793503761292, 0.333412766456604, -0.6837092638015747, -0.3012941777706146, -0.08594148606061935, 0.929815948009491, 0.3277515172958374, 0.37343740463256836, -0.16654141247272491, -0.20405104756355286, 0.14282342791557312, -0.18378114700317383, 0.05752820521593094, 0.16732440888881683, 0.29540932178497314, 0.24198885262012482, -0.2642922103404999, -0.22493276000022888, -0.1221894919872284, -0.25184428691864014, 0.24370801448822021, -0.3135523498058319, 0.05241497978568077, -0.4175042510032654, 0.2832152247428894, 0.16656213998794556, 0.10986076295375824, -0.4084066152572632, 0.4238031804561615, -0.5177638530731201, 0.22050704061985016, 0.23833028972148895, -0.017964839935302734, 0.13336122035980225, -0.4002001881599426, -0.10505073517560959, -0.4136592745780945, -0.4671153426170349, 0.19422321021556854, 0.4346628487110138, -0.40233686566352844, 0.13413207232952118, 0.3239254355430603, -0.16713598370552063, 0.3840610086917877, -0.574396014213562, -0.16588500142097473, -0.008444667793810368, -0.2875503599643707, 0.3365822732448578, -0.09225696325302124, -0.1632983386516571, 0.3551705777645111, -0.03150239959359169, 0.06431818753480911, 0.09545797854661942, -0.41542893648147583, 0.08071929961442947, 0.3869691789150238, -0.07203498482704163, 0.06288395822048187, 0.16186484694480896, 0.6255078315734863, 0.018664265051484108, 0.16210371255874634, 0.12287009507417679, -0.4892059862613678, -0.46972140669822693, 0.3577009439468384, -0.2067917436361313, 0.39981603622436523, -0.43355733156204224, -0.25392118096351624, -0.9671398401260376, 0.177718847990036, 0.7148418426513672, 0.41925039887428284, -0.21631786227226257, 0.09109783172607422, -0.026093829423189163, 0.24474816024303436, 0.27887803316116333, -0.41253259778022766, -0.4335175156593323, -0.43100395798683167, -0.4429320991039276, -0.6731886267662048, 0.5217340588569641, 0.11424236744642258, 0.3102489709854126, -0.22324368357658386, 0.35956355929374695, 0.3799300491809845, -0.4224005341529846, 0.552705705165863, -0.06642276793718338, 0.1766151636838913, -0.7400758862495422, 0.40160349011421204, -0.4291594326496124, -0.12482430785894394, 0.5410202145576477, 0.1716851443052292, 0.029339350759983063, -0.09967055171728134, 0.25076934695243835, -0.5701543688774109, 0.07489259541034698, -0.10936646908521652, 0.2657163441181183, 0.5090751051902771, -0.11268418282270432, 0.1344815194606781, -0.745877742767334, 0.2738947868347168, -0.11032608896493912, -0.5019493699073792, 0.01712445355951786, 0.12692062556743622, -0.6274951100349426, 0.258674293756485, 0.24887360632419586, -0.15595540404319763, -0.043110888451337814, -0.30908435583114624 ]
Helicobacter pylori induces motogenic and cytoskeletal responses in gastric epithelial cells. We demonstrate that these responses can be induced via independent signaling pathways that often occur in parallel. The cag pathogenicity island appears to be nonessential for induction of motility, whereas the elongation phenotype depends on translocation and phosphorylation of CagA.
[ -0.019451400265097618, 0.023140715435147285, -0.013877516612410545, 0.031686265021562576, 0.013700200244784355, 0.008589773438870907, 0.014543232508003712, 0.013261020183563232, -0.017230356112122536, -0.01325178425759077, -0.023278044536709785, 0.005354205146431923, -0.016303658485412598, 0.033661168068647385, -0.0274796299636364, 0.011554619297385216, 0.017801906913518906, 0.012731342576444149, 0.006289858371019363, 0.016503501683473587, 0.0010965073015540838, -0.00912535097450018, 0.013612223789095879, -0.05275626853108406, 0.03762911632657051, -0.0219678096473217, -0.012432301416993141, -0.016607416793704033, 0.004765723831951618, 0.0016426693182438612, 0.009448652155697346, 0.015171043574810028, 0.025763148441910744, -0.0067980121821165085, 0.005629946943372488, 0.00042607635259628296, -0.009612798690795898, 0.02302311547100544, 0.01702328398823738, -0.00697871670126915, 0.0029083439148962498, -0.015591406263411045, -0.004691440146416426, -0.0038586698938161135, -0.010223030112683773, -0.01476362906396389, -0.0006794590735808015, 0.028200840577483177, -0.0018560620956122875, 0.006711730267852545, -0.0066637615673244, -0.004535648971796036, -0.011916090734302998, 0.018868546932935715, -0.008675194345414639, 0.0166061669588089, 0.02226303145289421, -0.0008745932136662304, -0.001703393878415227, -0.0354175940155983, -0.0008203458273783326, -0.000010448953617014922, 0.01731196790933609, 0.00489075155928731, -0.007271863054484129, -0.06592955440282822, -0.0012398594990372658, -0.002115557435899973, -0.013252983801066875, 0.004952270537614822, -0.019534219056367874, 0.008123524487018585, -0.005836622789502144, -0.00587471853941679, 0.004095137119293213, -0.008553517051041126, -0.036030229181051254, 0.00416084099560976, 0.02149352617561817, -0.0027913288213312626, 0.007244252599775791, -0.0422247089445591, -0.027804479002952576, 0.027296438813209534, -0.01136967446655035, 0.003062798175960779, -0.0188989769667387, 0.018007909879088402, 0.006227594334632158, -0.0005872502224519849, 0.0109100341796875, -0.013644845224916935, -0.007196012884378433, -0.0000857370687299408, -0.035438504070043564, 0.03094249963760376, 0.0048742215149104595, 0.01651313714683056, -0.015766579657793045, 0.0005305435624904931, -0.016903314739465714, -0.004566258750855923, 0.02772749587893486, -0.009040541015565395, -0.01622241735458374, 0.009258749894797802, 0.00781683437526226, 0.012083595618605614, 0.02538635954260826, 0.019363097846508026, -0.004888967145234346, -0.01054163184016943, 0.000057871573517331854, 0.028154075145721436, 0.01634395308792591, -0.026743734255433083, -0.012794051319360733, 0.0057122958824038506, 0.018547894433140755, 0.02396974340081215, 0.05688810348510742, -0.0014002748066559434, 0.0010370136005803943, 0.019313720986247063, 0.007302072364836931, -0.006204644683748484, -0.01619105599820614, -0.011195158585906029, 0.01589173637330532, 0.0007644792785868049, -0.010616442188620567, 0.010325703769922256, 0.06372226029634476, 0.03346380218863487, 0.015202991664409637, -0.00024438518448732793, -0.037105217576026917, 0.006357200909405947, -0.005510168150067329, -0.011502179317176342, -0.012260419316589832, 0.01152199786156416, 0.0019452295964583755, 0.006132760550826788, 0.01507140975445509, 0.006345023401081562, 0.00591339822858572, -0.001730387913994491, -0.00013913084694650024, -0.013829315081238747, 0.01836094819009304, 0.02072441577911377, -0.050191350281238556, -0.021803338080644608, 0.018071088939905167, 0.03111913986504078, -0.034326277673244476, -0.015242546796798706, -0.008570396341383457, 0.005391810555011034, -0.004461756441742182, -0.0574306957423687, 0.036336589604616165, 0.01617458090186119, -0.01088816486299038, 0.0018620280316099524, 0.01350985374301672, -0.017561858519911766, 0.017204590141773224, 0.013408134691417217, -0.013393507339060307, 0.040632378309965134, -0.012340813875198364, 0.006346868351101875, -0.00316893239505589, -0.011722042225301266, -0.01103191263973713, 0.009394241496920586, -0.02165011316537857, 0.06601991504430771, 0.03745158761739731, -0.012600458227097988, -0.0045303767547011375, -0.05670878291130066, 0.018753914162516594, 0.005529576446861029, -0.020174114033579826, -0.010184199549257755, 0.00529021630063653, -0.01124038640409708, -0.019709860906004906, 0.0034352410584688187, 0.0072518824599683285, 0.0009812868665903807, 0.010777745395898819, 0.0031337665859609842, 0.009122285060584545, 0.010426793247461319, -0.022469816729426384, -0.0090055325999856, 0.03991185128688812, -0.02489727921783924, 0.023219432681798935, -0.019600220024585724, -0.017657935619354248, -0.0014465713175013661, -0.008722069673240185, -0.018629290163517, -0.04468275234103203, 0.010908388532698154, 0.012258500792086124, -0.00006013525489834137, 0.008670425973832607, -0.009747727774083614, -0.012516923248767853, 0.02750459685921669, -0.008280924521386623, 0.015471640974283218, -0.03848845139145851, -0.012287835590541363, -0.00045826617861166596, 0.022425485774874687, -0.01846584677696228, 0.017060209065675735, -0.020168432965874672, -0.04359085485339165, -0.00853681843727827, 0.017305785790085793, -0.0007804100750945508, 0.0077842785976827145, -0.01733396016061306, 0.0075511634349823, -0.020103847607970238, 0.017463350668549538, 0.01268455944955349, 0.004428536165505648, 0.023798909038305283, 0.006224212236702442, 0.024028414860367775, -0.013170278631150723, 0.006961663253605366, -0.005961297545582056, 0.08512022346258163, -0.0018507548375055194, -0.035267964005470276, 0.01918928697705269, 0.02938837558031082, 0.042353685945272446, 0.014051138423383236, -0.0024835101794451475, 0.012006047181785107, 0.026066888123750687, 0.00025042923516593874, -0.03433942794799805, 0.02449723891913891, -0.019954826682806015, -0.014685734175145626, 0.004735583905130625, 0.028041327372193336, 0.0018239759374409914, 0.013107550330460072, 0.004575646948069334, 0.005869672168046236, -0.03725973516702652, -0.0418032668530941, 0.0030713113956153393, 0.024598557502031326, 0.011793822050094604, 0.024449724704027176, -0.01667727530002594, 0.014341623522341251, -0.011591210030019283, -0.0032145455479621887, -0.08059366047382355, -0.01546790823340416, -0.026114080101251602, -0.027807440608739853, 0.0066509549506008625, 0.0017087588785216212, 0.01465456373989582, 0.019789237529039383, -0.00912675354629755, -0.00424607377499342, 0.01625947840511799, 0.015778398141264915, 0.0032540096435695887, -0.006109996233135462, 0.005521989427506924, -0.004079747013747692, 0.020233560353517532, 0.014730194583535194, 0.009458204731345177, -0.015633173286914825, 0.03576331585645676, -0.02308317832648754, 0.016048770397901535, -0.004884776193648577, 0.03803035616874695, 0.006221186835318804, 0.007679437752813101, 0.017897233366966248, -0.02425498329102993, -0.0025541428476572037, 0.013545364141464233, -0.013551047071814537, 0.040862906724214554, 0.02605525590479374, 0.021969353780150414, -0.001994051970541477, 0.003120203735306859, 0.02075969986617565, -0.027072057127952576, 0.0273831095546484, -0.018529530614614487, 0.008904721587896347, 0.031017469242215157, -0.00458118598908186, 0.0034151135478168726, -0.00009304365812567994, -0.02684037573635578, -0.035666324198246, 0.019661426544189453, 0.011442583985626698, -0.0005941235576756299, 0.0061763739213347435, 0.016343118622899055, 0.027873245999217033, -0.023558754473924637, 0.00411948561668396, -0.04482121393084526, 0.01172744669020176, -0.016561293974518776, -0.019296156242489815, 0.05597151443362236, 0.02160782366991043, 0.007824611850082874, 0.02355654165148735, -0.025617625564336777, -0.02538587711751461, 0.025363797321915627, -0.004757757298648357, -0.025696074590086937, 0.028829356655478477, 0.003441289998590946, 0.007595117203891277, -0.0296512171626091, -0.013062913902103901, 0.004743050783872604, -0.005340881180018187, -0.01296259742230177, -0.012002341449260712, 0.002337195910513401, -0.027686549350619316, -0.018519587814807892, 0.016304368153214455, -0.003407686948776245, -0.0016451362753286958, -0.015238996595144272, 0.0019358727149665356, 0.020068388432264328, 0.04093220457434654, 0.017581256106495857, -0.01851826161146164, 0.008023600094020367, 0.027056679129600525, -0.004262757487595081, 0.017910806462168694, 0.0028003761544823647, 0.0027069703210145235, -0.006505941040813923, 0.005041998811066151, 0.012824555858969688, 0.010274626314640045, -0.024435989558696747, -0.007738360669463873, -0.046296533197164536, -0.006218194495886564, -0.03285134956240654, 0.015363332815468311, 0.008535725064575672, -0.004016281571239233, -0.007211120333522558, -0.0023676797281950712, 0.009817540645599365, -0.04007697105407715, -0.012467453256249428, -0.015164419077336788, 0.008135192096233368, 0.0049792141653597355, -0.014330489560961723, 0.006543730851262808, 0.07055386900901794, 0.002539827721193433, -0.016103634610772133, -0.02349540777504444, 0.03003750741481781, -0.04817406088113785, -0.026096517220139503, 0.010884546674787998, -0.011186686344444752, 0.017432410269975662, 0.016459662467241287, -0.06919009238481522, -0.01080064196139574, 0.020385732874274254, -0.04318211227655411, -0.008558421395719051, -0.019739702343940735, -0.03829490393400192, 0.0016927541000768542, 0.023761462420225143, 0.025648215785622597, -0.009153368882834911, 0.00017408152052666992, 0.006416217889636755, 0.019829081371426582, -0.02967650815844536, -0.01026688702404499, -0.013127187266945839, -0.02705238200724125, 0.016507333144545555, -0.005037459544837475, -0.04552437365055084, -0.016775812953710556, -0.007464476395398378, 0.0132795050740242, 0.018951531499624252, 0.01328191813081503, 0.022704098373651505, -0.020593509078025818, -0.002410887274891138, -0.01498434878885746, -0.014178236946463585, 0.00481884041801095, 0.007528405636548996, -0.046803977340459824, -0.0061636497266590595, 0.002317735692486167, -0.008319814689457417, -0.0002989739878103137, 0.0012675191974267364, -0.021798400208353996, -0.008832581341266632, 0.013842582702636719, 0.017836254090070724, 0.01427749078720808, 0.013464176096022129, 0.02629150077700615, 0.0011697461595758796, 0.005037887487560511, 0.007995722815394402, 0.009128844365477562, -0.019877929240465164, 0.02073904313147068, -0.010322648100554943, 0.017301788553595543, -0.010263157077133656, -0.02734246477484703, 0.003206330817192793, 0.01813972182571888, -0.013688276521861553, 0.022444626316428185, -0.020963575690984726, -0.010202491655945778, 0.001679859240539372, -0.013766123913228512, 0.007963323965668678, 0.020523659884929657, -0.02943393401801586, -0.02305924892425537, 0.002241725567728281, 0.004269979894161224, 0.06136102229356766, -0.0032576066441833973, -0.007448663003742695, -0.010457411408424377, -0.05718664452433586, -0.05727002024650574, -0.07339291274547577, -0.019244970753788948, -0.03288304805755615, -0.0029244404286146164, 0.012533665634691715, 0.0008938837563619018, -0.023640422150492668, -0.004992993548512459, 0.005782870575785637, -0.013032018207013607, -0.023700179532170296, -0.023755783215165138, -0.03791037201881409, 0.005730413366109133, 0.012355000711977482, 0.030041063204407692, -0.028154103085398674, 0.008047336712479591, -0.03695804998278618, -0.00038311208481900394, 0.027341386303305626, 0.016703665256500244, -0.0034750583581626415, 0.0023903343826532364, 0.009345097467303276, -0.07911144942045212, 0.0064894407987594604, 0.006359913852065802, 0.02680436335504055, 0.04862949997186661, -0.01443190686404705, 0.0064152381382882595, -0.006811024621129036, -0.06275536119937897, -0.020870938897132874, -0.00010366284550400451, -0.019206030294299126, -0.004857792053371668, -0.029339652508497238, 0.002470491686835885, -0.015911772847175598, 0.011445684358477592, 0.012637322768568993, 0.0174076110124588, 0.011231107637286186, -0.01690724305808544, 0.03570486977696419, -0.01789180189371109, -0.026327695697546005, -0.010174763388931751, -0.02714170143008232, 0.03913949802517891, 0.012159070000052452, 0.007203366607427597, -0.05007442831993103, -0.04408494755625725, -0.00936217326670885, -0.021602610126137733, 0.030551521107554436, -0.031130095943808556, -0.03085937723517418, 0.025310112163424492, 0.0014893999323248863, -0.000031107145332498476, -0.008568817749619484, -0.00844463612884283, 0.02226308546960354, -0.0022300616838037968, 0.016678404062986374, -0.009415700100362301, -0.05465615168213844, 0.0032330264803022146, -0.01978878676891327, 0.028935452923178673, 0.007905024103820324, 0.00005172986857360229, 0.0030107488855719566, 0.013603292405605316, -0.021576518192887306, -0.005341231357306242, 0.005880811717361212, -0.007940840907394886, 0.04176950454711914, 0.02344006858766079, 0.000470183789730072, 0.009018619544804096, 0.011866459622979164, -0.00460590235888958, 0.07081802934408188, 0.00721358135342598, 0.028162023052573204, 0.014213800430297852, 0.00479517737403512, 0.012676875106990337, -0.00790972076356411, -0.035364117473363876, -0.031081628054380417, -0.018584826961159706, 0.003870958462357521, -0.015111658722162247, 0.004074546508491039, 0.016034523025155067, 0.07430282980203629, 0.0017643297323957086, -0.021002186462283134, 0.006639796309173107, -0.04012643173336983, -0.014361524023115635, 0.019490240141749382, -0.028826627880334854, 0.002973090158775449, -0.002872880781069398, 0.01670759730041027, -0.023972054943442345, -0.015299157239496708, 0.002997397677972913, -0.04126950353384018, 0.0173422172665596, 0.0015306122368201613, -0.015024262480437756, 0.00031631189631298184, -0.02644956298172474, 0.011798110790550709, 0.028435397893190384, 0.004260543268173933, 0.01022273302078247, -0.01979033276438713, 0.0026048007421195507, 0.0036459111142903566, 0.019242247566580772, -0.005719848442822695, -0.03437031805515289, 0.01289090234786272, -0.015441877767443657, 0.0032761376351118088, -0.0025664533022791147, 0.0031999333295971155, 0.013781547546386719, -0.02837369032204151, -0.011075873859226704, -0.014781286008656025, -0.018328210338950157, -0.0013966383412480354, 0.0156222153455019, 0.010521318763494492, 0.021497754380106926, -0.0042251585982739925, 0.019160259515047073, 0.027417533099651337, -0.01014962699264288, -0.006806171033531427, -0.02513062208890915, -0.00623693410307169, 0.011160475201904774, 0.01776883937418461, -0.02100255712866783, -0.058461397886276245, 0.018016213551163673, -0.022995062172412872, -0.009714565239846706, 0.01227548997849226, -0.009076015092432499, 0.04075300320982933, -0.003317521419376135, 0.02111032046377659, 0.013172052800655365, 0.04681998863816261, -0.0015272637829184532, -0.022483794018626213, -0.01123741827905178, -0.008764317259192467, 0.033489782363176346, -0.01706482097506523, 0.002770890248939395, 0.019139451906085014, -0.0021937061101198196, 0.0006876604747958481, 0.017660457640886307, -0.03105078637599945, 0.007700481917709112, -0.00009317015792476013, 0.01780751720070839, 0.013916028663516045, 0.035229671746492386, 0.022971317172050476, 0.004158731549978256, -0.028691856190562248, 0.0014467360451817513, -0.036592546850442886, 0.001968963071703911, -0.019938308745622635, -0.018968934193253517, -0.02085103467106819, -0.01931055821478367, 0.03788178786635399, 0.004453962203115225, 0.021053588017821312, -0.03469095379114151, -0.0073153492994606495, -0.018682027235627174, 0.03956951946020126, 0.00582602946087718, 0.020809512585401535, -0.011135839857161045, -0.035573165863752365, -0.01172404270619154, 0.006302050780504942, -0.015588195063173771, -0.00960646290332079, 0.00673593208193779, -0.022394254803657532, 0.0022877908777445555, 0.012178126722574234, -0.010869638063013554, -0.020967310294508934, 0.0334056057035923, -0.034987036138772964, -0.030323166400194168, 0.01746744103729725, -0.0024385577999055386, -0.0293548833578825, 0.029034370556473732, -0.028744274750351906, -0.0015253250021487474, -0.04705001413822174, 0.013508941978216171, -0.010422215797007084, 0.04566732048988342, 0.015918269753456116, -0.0070687951520085335, 0.009146464988589287, -0.028201639652252197, 0.007535342127084732, 0.0020934564527124166, 0.012787655927240849, 0.007506439927965403, 0.01841663010418415, 0.0009163478971458972, 0.001192153780721128, -0.001714137615635991, -0.014841037802398205, -0.013312084600329399, 0.004534824285656214, 0.01171554159373045, 0.005443817935883999, -0.014850414358079433, -0.011315573938190937, -0.039744067937135696, 0.01677047088742256, 0.0011816329788416624, 0.0008286872762255371, 0.014973401091992855, 0.016651727259159088, 0.011214468628168106, 0.0006553381681442261, 0.023611413314938545, 0.011635230854153633, -0.003295956179499626, 0.0015716158086434007, 0.033785007894039154, -0.018338175490498543, -0.0017323532374575734, -0.044596489518880844, -0.0006892058881931007, -0.0053626433946192265, -0.0052005453035235405, 0.019048934802412987, -0.012984617613255978, 0.0029444622341543436, -0.02914593555033207, -0.007170762866735458, -0.0054047792218625546, -0.016662847250699997, 0.00903134886175394, -0.015963377431035042, -0.008168017491698265, 0.015485399402678013, 0.02188110165297985, -0.028092961758375168, 0.01613711006939411, 0.0027732658199965954, 0.03329058736562729, -0.02551991306245327, -0.04425870254635811, 0.007293206173926592, -0.03266939893364906, 0.010387354530394077, -0.010058227926492691, 0.009756931103765965, -0.01857241429388523 ]
[ 0.061148472130298615, 0.36089423298835754, 0.24360275268554688, 0.021044330671429634, -0.29238519072532654, 0.056809935718774796, 0.28298142552375793, -0.2423344850540161, -0.0127484742552042, -0.3506368398666382, 0.1267196089029312, -0.07322950661182404, -0.5083639621734619, 0.15296286344528198, 0.16638706624507904, 0.4885326325893402, 0.5994517803192139, 0.5466472506523132, -0.40475234389305115, -0.6133354902267456, -0.289418488740921, -0.2108190804719925, 0.8068811297416687, -0.1807485669851303, 0.16435913741588593, -0.43842029571533203, 0.1620989590883255, 0.5928123593330383, 0.30178743600845337, -0.3748590052127838, -0.021539125591516495, 0.35493573546409607, 0.23441721498966217, -0.2218896448612213, 0.11491769552230835, 0.2525152564048767, -0.1732567399740219, -0.4768465757369995, -0.09228479117155075, -0.08283459395170212, -0.3486576974391937, -0.08675911277532578, -0.04791434109210968, 0.29417169094085693, -0.47755905985832214, 0.025758160278201103, -1.3210951089859009, 0.7041627168655396, -0.18560849130153656, 0.18928459286689758, 0.13825099170207977, -0.11022830754518509, 0.22303009033203125, -0.17542582750320435, 0.5481711626052856, 0.31501010060310364, -1.0352187156677246, 0.023044398054480553, 0.2954731285572052, -0.7691189646720886, -0.43283531069755554, -0.31123197078704834, -0.2789078652858734, -0.10920291393995285, 0.25646770000457764, 0.8568134307861328, -0.2695251703262329, -0.6734601855278015, -0.3134908378124237, 0.19410045444965363, 0.13242632150650024, -0.6737552285194397, -0.19905641674995422, 0.3488466143608093, 0.07258515059947968, 0.024187693372368813, -0.5326781272888184, -0.41479748487472534, 0.24728557467460632, 0.017768027260899544, -0.030035721138119698, -0.15102161467075348, 0.21568182110786438, 0.20458853244781494, 0.22792509198188782, 0.3570561408996582, -0.09484990686178207, 0.9506435990333557, -0.32926878333091736, -0.40967637300491333, -0.24004007875919342, -0.1359090954065323, 0.6336104869842529, 0.4636876583099365, -0.096817746758461, 0.571567714214325, 0.36688336730003357, 0.05792622268199921, 0.07384145259857178, 0.45523136854171753, -0.3493654727935791, 0.40382131934165955, -0.14786045253276825, -0.15238548815250397, -0.02143784426152706, -0.1797458976507187, -0.33763328194618225, -0.555358350276947, -0.4698348939418793, 0.10318303853273392, -0.526555597782135, 0.16969846189022064, -0.2590637803077698, -0.10343233495950699, -0.008204836398363113, 0.09111212193965912, 0.3854544162750244, -0.321865975856781, 0.10422976315021515, 0.45703521370887756, -0.3399472236633301, 1.045703411102295, -0.02111869864165783, 0.4068039357662201, -0.3523217439651489, -0.16850022971630096, -0.3762207627296448, 0.27019545435905457, -0.2093111127614975, 0.371009886264801, 0.07555161416530609, 0.6700595617294312, -0.3374651372432709, 0.22363124787807465, 0.2888399362564087, -0.5407928824424744, -0.159501314163208, 0.2821906507015228, 0.5846503376960754, 0.36975833773612976, -0.7419147491455078, -0.4725222885608673, -0.3726111650466919, 0.1170264184474945, -0.31569918990135193, -0.5810195803642273, -0.30675339698791504, -0.004924732726067305, 0.0008993329829536378, -0.13231657445430756, 0.33762556314468384, -0.33198899030685425, -0.5750399827957153, -0.17685812711715698, -0.3341454267501831, 0.27317318320274353, 0.10479940474033356, -0.20925301313400269, -0.2301183044910431, 0.11644979566335678, -0.3000628352165222, -0.43899884819984436, -0.3094862997531891, 0.07346569001674652, 0.3210642635822296, 0.004866789095103741, 0.46928712725639343, 0.5113809108734131, -0.14129801094532013, -0.02351091243326664, -0.11219505220651627, -0.2399265170097351, 0.22747991979122162, -0.6756722331047058, 0.42093193531036377, -0.03732847794890404, 0.16115425527095795, -0.03366130217909813, 0.16297800838947296, -0.08470641076564789, -0.6663950681686401, 0.4661535918712616, -0.3000561594963074, -0.29926005005836487, 0.38849061727523804, 0.04004926234483719, 0.3586072623729706, -0.3376631438732147, 0.3134186565876007, -0.4431360065937042, 0.042556941509246826, -0.44216465950012207, 1.000996708869934, -0.802078902721405, 1.1164442300796509, -0.12691956758499146, -0.10181353986263275, -0.0913872942328453, 0.1331346035003662, -0.24704279005527496, -0.16178688406944275, 0.07982216030359268, 0.22249610722064972, -0.4414851665496826, -1.000065565109253, 0.07739891856908798, -0.14912869036197662, 0.13277199864387512, 0.593777060508728, -0.045559220016002655, 0.20074348151683807, -0.5010937452316284, 0.2528476417064667, -0.4355270564556122, 0.13205671310424805, -0.4939429461956024, 0.04116774722933769, -0.010458283126354218, -0.2778249979019165, -0.08671632409095764, 0.28445059061050415, -0.29947835206985474, 0.4584871530532837, 1.1970826387405396, -0.08450663089752197, 0.5078085064888, 0.88172447681427, -0.22282947599887848, 1.1601142883300781, -0.4190739393234253, 0.8483988642692566, -0.2647475600242615, 0.14598271250724792, -0.607903778553009, -0.07556445151567459, 0.2508995532989502, 0.25759202241897583, -0.18959134817123413, 0.5015485882759094, -0.28401637077331543, -0.023619595915079117, 0.2560539245605469, -0.5767837762832642, 0.10408163070678711, -0.21700482070446014, -0.42892929911613464, -0.0765451118350029, 0.3901907801628113, -1.033108115196228, -0.10931526124477386, 0.28696608543395996, 0.6789630055427551, 0.2742202877998352, -0.6604064702987671, 0.4012467563152313, -0.11243859678506851, -0.3433929681777954, -0.09700953960418701, 0.021850796416401863, -0.4604833722114563, -0.28621554374694824, -0.13655105233192444, 0.016707735136151314, 0.4314398467540741, 0.4495333135128021, -0.32648730278015137, -0.661117434501648, -0.2143319994211197, 0.5447067618370056, 0.5004821419715881, 0.8557410836219788, 0.03477662429213524, -0.9643701314926147, -0.33362266421318054, -0.012394064106047153, -0.38460275530815125, -0.05060887336730957, 0.07280517369508743, -0.5963391661643982, -0.45852130651474, -0.3880654573440552, 0.6225516200065613, 0.26052623987197876, 0.09085050970315933, -0.1553129106760025, 0.03332153707742691, -0.5273927450180054, -0.1999153196811676, 0.12416791170835495, -0.6732300519943237, -0.30112314224243164, 0.24051575362682343, -0.27369749546051025, 0.22836458683013916, 0.0656881108880043, 0.09738355129957199, -0.2143789678812027, 0.18405382335186005, 0.9743162989616394, -0.1361791044473648, -0.21992550790309906, -0.210236594080925, -0.3549475371837616, 0.0649598017334938, -0.20279665291309357, 0.1877259761095047, -0.5124896168708801, 0.40159088373184204, -5.8053107261657715, -0.05657992139458656, 0.03617361932992935, 0.07790467143058777, 0.4298146069049835, -0.22367559373378754, 0.8134015798568726, 0.113376684486866, 0.4206261932849884, 0.21663610637187958, 0.4851504862308502, 0.2733469009399414, 0.03801481053233147, 0.2625790238380432, -0.21604616940021515, -0.22041623294353485, -0.34994760155677795, -0.8171908259391785, 0.5096673965454102, -0.2970881164073944, -0.2619011104106903, -0.006375520955771208, 0.12301577627658844, 0.6632273197174072, -0.07115155458450317, -0.2654516100883484, -0.7977468371391296, 0.20151971280574799, -0.34423765540122986, 0.22037607431411743, -0.465617835521698, -0.6592199206352234, 0.038292866200208664, 0.0189238078892231, 0.2730843126773834, -0.15945687890052795, -0.15301233530044556, -0.013523346744477749, -0.47024914622306824, -0.014455117285251617, 0.510558009147644, 0.09034750610589981, -0.25662535429000854, 0.21631112694740295, 0.42532527446746826, -0.1746280938386917, 0.1586393564939499, -0.25366872549057007, -0.1803896576166153, 1.1470355987548828, 0.6469578742980957, 0.06364922225475311, 0.29690417647361755, 0.5557119250297546, 0.6945590972900391, 0.5115344524383545, 0.4703156650066376, -0.31051182746887207, -0.17749597132205963, -0.17488734424114227, -0.386555939912796, -0.028559595346450806, -0.26098811626434326, -0.1412220001220703, -0.06880735605955124, 0.3160857558250427, -0.6902920007705688, 0.17803898453712463, 0.5456656217575073, -0.6492563486099243, -0.4059475362300873, 0.2852591872215271, 0.14700841903686523, -0.9321938753128052, 0.9180980920791626, -0.37089335918426514, 0.10067707300186157, 0.04207555577158928, 0.40507596731185913, 0.02321670576930046, -0.13283441960811615, 0.13756786286830902, -0.0671844556927681, -0.24767635762691498, 0.10122039169073105, -0.24828360974788666, -0.1670617312192917, -0.41077908873558044, -0.23557789623737335, 0.3122825026512146, 0.08734912425279617, -0.2690912187099457, -0.06348089873790741, 0.1849375218153, 0.2939029633998871, 0.7679175734519958, 0.2781546711921692, 0.7699120044708252, 0.5533506870269775, 0.007035666611045599, 0.8641853332519531, -0.31435927748680115, -0.8757878541946411, -0.28625863790512085, 0.11440836638212204, -0.01763230562210083, -0.3819139897823334, 0.37015703320503235, 0.6387190222740173, -0.8361976146697998, 0.4959598183631897, 0.0003910342638846487, -0.6755844354629517, -0.31609126925468445, 0.8986746668815613, -0.16043010354042053, -0.13713021576404572, 0.4834998846054077, 1.2298587560653687, -0.5810543894767761, 0.12528613209724426, 0.42002326250076294, -0.5804747939109802, -0.07777032256126404, 0.33210188150405884, 0.3764059543609619, 0.16089527308940887, 0.7905905842781067, -0.34171855449676514, -0.035813990980386734, -0.3110114634037018, 0.1300373077392578, -0.3091166317462921, 0.08954373747110367, 0.3257119953632355, -0.18630175292491913, -0.4528006911277771, 0.05939308553934097, -0.2267436683177948, -0.1957957148551941, 0.39997363090515137, -0.47858667373657227, -0.014256423339247704, 0.18254674971103668, 0.5064626336097717, -0.0780240148305893, -0.24054577946662903, -0.05645829811692238, -0.10353947430849075, -0.07223572582006454, 0.4551123380661011, 0.012464901432394981, 0.4434155821800232, -0.3301328122615814, 0.010411008261144161, 0.15043994784355164, 0.3002918064594269, 0.6102719902992249, 0.15943098068237305, -0.7707046270370483, 0.39574697613716125, 0.4054831564426422, -1.0280321836471558, -0.2429795116186142, -0.5188985466957092, -0.14602024853229523, -0.04746212810277939, -0.2819470465183258, -0.5217347145080566, 0.37608662247657776, -0.47363701462745667, -0.0942741110920906, -0.3817126154899597, -0.15635067224502563, 0.03331820294260979, -0.5676621198654175, -0.3505869209766388, -0.2004013955593109, -0.022216683253645897, -0.1546850949525833, -0.32568830251693726, -0.32423847913742065, -0.2862372398376465, 0.14811500906944275, 0.5206984877586365, 0.1450653225183487, 0.4753835201263428, -0.5524227023124695, -0.38731881976127625, -0.14815908670425415, -0.02355918474495411, 0.24735412001609802, -0.030799202620983124, 0.12186877429485321, 0.060723718255758286, 0.21676547825336456, 0.19693447649478912, 0.1990605890750885, -0.2795918583869934, -0.5338161587715149, 0.46435636281967163, 0.010231640189886093, -0.4126993715763092, -0.19678503274917603, 0.7700114250183105, -0.03010309673845768, 0.2707507610321045, -0.26056167483329773, 0.13133706152439117, 0.059901706874370575, 0.3101780116558075, -0.35612258315086365, -0.22472594678401947, 0.4529706835746765, -0.3308538496494293, -0.3767881691455841, 0.05564985051751137, -0.14226195216178894, -0.05857253447175026, 0.4707438051700592, 0.7282147407531738, -0.026692261919379234, 0.08134587854146957, -0.3446495831012726, -0.6468998789787292, 0.195658341050148, 0.5509626269340515, -0.35860246419906616, 0.09494463354349136, 0.2796834409236908, 0.3441811800003052, -0.4196242094039917, 0.13599902391433716, 0.053124841302633286, -0.21193309128284454, -0.2782430052757263, -0.29833105206489563, 0.2509179711341858, -0.4276740252971649, 0.36728769540786743, 0.4136078953742981, 0.5096480250358582, -0.538481593132019, -0.16547884047031403, -0.18772609531879425, 0.7838263511657715, 0.36057761311531067, -0.3573732376098633, -0.39456140995025635, 0.1469738930463791, 0.4113105237483978, 0.20581863820552826, 0.26905786991119385, 0.6890519857406616, 0.7037311792373657, -0.2921481728553772, 0.34447014331817627, -0.2408471405506134, -0.01666756346821785, 0.5304475426673889, -0.531621515750885, 0.36837881803512573, -0.3338409662246704, 0.09354286640882492, 0.06478121876716614, -0.24939148128032684, -0.13982705771923065, -0.5101774334907532, 0.39256569743156433, -0.07640822976827621, -0.5937986373901367, 0.23433032631874084, 0.5335159301757812, 0.15652069449424744, -0.1969641000032425, 0.7601990103721619, -0.6161421537399292, -0.18123069405555725, -0.19110557436943054, 0.3347587287425995, -0.44879093766212463, -0.7437885403633118, -0.22988758981227875, 0.11825589090585709, 0.2719798684120178, -0.34406793117523193, -0.26681825518608093, -0.7035842537879944, 0.11537682265043259, -0.45858004689216614, -0.2812347412109375, -0.09298437088727951, -0.6188506484031677, -0.45417073369026184, 0.6698605418205261, -0.024226462468504906, 0.11753138899803162, -0.18029434978961945, -0.06476608663797379, 0.0845903605222702, -0.6074605584144592, 0.23357784748077393, 0.5646305680274963, -0.40160509943962097, 0.08008614927530289, 0.31479600071907043, -0.13934899866580963, 0.0023834144230931997, -0.5570708513259888, -0.40896543860435486, 0.2726101875305176, 0.18412011861801147, -0.2548215389251709, 0.04099086672067642, -0.2211814671754837, 0.3791772127151489, -0.10317615419626236, -0.3384150564670563, 0.06424476206302643, 0.5801210403442383, 0.7661689519882202, 0.5824839472770691, 0.5033485889434814, -0.37140098214149475, -0.008678767830133438, 0.24624694883823395, -0.060660600662231445, 0.4377855062484741, 0.3470720946788788, 0.3615553677082062, 0.5942797064781189, 0.016330281272530556, -0.10141617804765701, 0.6918809413909912, 0.3942468762397766, 0.42405155301094055, -0.1009388118982315, -0.4635077118873596, -0.37503018975257874, 0.21050775051116943, 0.8346606492996216, 0.07952378690242767, 0.11843439191579819, -0.45483890175819397, 0.6289762854576111, 0.42607295513153076, 0.05744076520204544, -0.2775113880634308, -0.07697854191064835, 0.7584577798843384, 0.3936411738395691, -0.5702065825462341, -0.1410805732011795, -0.3983493745326996, -0.650770366191864, 0.18169517815113068, 0.34852293133735657, -0.13948999345302582, -0.8044375777244568, 0.08578561246395111, -0.09747622162103653, -0.1759374886751175, -0.5750721096992493, 0.6643136143684387, -0.07222503423690796, 0.10967262089252472, 0.37640032172203064, 0.08903832733631134, 0.26760172843933105, 0.24155357480049133, -0.26827794313430786, -0.3390966057777405, -0.43332237005233765, -0.11301086097955704, 0.2942974269390106, -0.08726806193590164, 0.311916321516037, 0.03683879226446152, 0.16992205381393433, 0.39756080508232117, -0.7478690147399902, 0.5342848300933838, -0.23961135745048523, -0.2763154208660126, -0.411773145198822, -0.27421334385871887, 0.041499145328998566, -0.23668064177036285, -0.24002958834171295, 0.053733646869659424, -0.0032009228598326445, -0.21529479324817657, -0.04347041994333267, 0.2790141701698303, 0.3992125988006592, -0.23086075484752655, 0.21276172995567322, -0.03701309114694595, 0.2429376095533371, 0.10389061272144318, 0.01357987429946661, 0.05803252011537552, 0.060189228504896164, 0.10347747802734375, -0.18176722526550293, 0.3217475712299347, -0.18800683319568634, -0.1768575757741928, -0.6012536287307739, 0.013705923222005367, 1.1359647512435913, 1.2170310020446777, -0.47103583812713623, 0.11694018542766571, 0.4547787010669708, 0.20520956814289093, 0.16216467320919037, -0.31995806097984314, -0.2512778341770172, -0.7871384620666504, 0.050549209117889404, -0.42882534861564636, 0.8746387958526611, 0.09608736634254456, 0.14231880009174347, -0.1755858212709427, 0.18823251128196716, 0.05839311331510544, -0.21110855042934418, 0.3040013015270233, 0.03267916291952133, 0.3343842923641205, -0.5552751421928406, 0.42753875255584717, -0.4037187397480011, 0.11535073816776276, -0.39334729313850403, 0.13367442786693573, -0.12582415342330933, -0.47890034317970276, 0.7643189430236816, -0.5018299221992493, 0.16781702637672424, -0.448076456785202, -0.1809999793767929, 0.06156408414244652, 0.11430545151233673, -0.3774917423725128, -0.3979095220565796, -0.0052564069628715515, 0.12797565758228302, -0.9603970050811768, 0.16560885310173035, 0.06962762773036957, -0.3057851195335388, -0.13429686427116394, -0.08002030104398727, -0.07677457481622696, -0.023238204419612885, 0.0972733125090599 ]
SUMMARY The Sequence Alignment/Map (SAM) format is a generic alignment format for storing read alignments against reference sequences, supporting short and long reads (up to 128 Mbp) produced by different sequencing platforms. It is flexible in style, compact in size, efficient in random access and is the format in which alignments from the 1000 Genomes Project are released. SAMtools implements various utilities for post-processing alignments in the SAM format, such as indexing, variant caller and alignment viewer, and thus provides universal tools for processing read alignments. AVAILABILITY http://samtools.sourceforge.net.
[ -0.008880013599991798, 0.007973253726959229, -0.004969557747244835, 0.015591353178024292, 0.02404835820198059, 0.014734877273440361, 0.009261165745556355, 0.0248759463429451, -0.0104951411485672, 0.0190868116915226, -0.009234802797436714, 0.00887373648583889, -0.008675395511090755, 0.01863827183842659, 0.003987063653767109, 0.003747201059013605, -0.017986655235290527, 0.00035968096926808357, 0.01055067777633667, -0.0038613821379840374, 0.029349524527788162, -0.003204932203516364, 0.007431965321302414, 0.007983263581991196, -0.017820673063397408, -0.01678534224629402, 0.013644909486174583, 0.021224018186330795, 0.008988034911453724, 0.010987660847604275, -0.026050124317407608, -0.007668410427868366, 0.007517924066632986, 0.007210324518382549, -0.004503158852458, -0.01868426240980625, -0.016028134152293205, 0.013729163445532322, -0.004665527027100325, -0.00514727458357811, -0.011860720813274384, -0.010548325255513191, 0.0032977203372865915, -0.004421483725309372, -0.007951564155519009, 0.006498160772025585, -0.004941460210829973, -0.004300585947930813, 0.003971335478127003, 0.006870215758681297, -0.01765374466776848, 0.011465557850897312, -0.0008593248785473406, -0.04593176022171974, -0.004824771545827389, -0.039057016372680664, 0.01569727435708046, -0.020258266478776932, -0.011042876169085503, -0.01182617899030447, 0.0010763304308056831, 0.030399946495890617, 0.02239624783396721, -0.011268184520304203, -0.036358047276735306, -0.06733748316764832, 0.02426617220044136, 0.018027780577540398, -0.013234982267022133, -0.02305835485458374, 0.017134569585323334, 0.005680835340172052, -0.019960347563028336, 0.006480701267719269, -0.005211487878113985, -0.022066768258810043, -0.02685191109776497, -0.008097460493445396, -0.0004534998442977667, 0.005471987649798393, -0.011487091891467571, -0.015153411775827408, 0.01779402792453766, 0.00276746298186481, -0.013055012561380863, 0.0009924140758812428, -0.014143125154078007, 0.008986059576272964, 0.013906732201576233, -0.01604234240949154, 0.027697376906871796, 0.013970217667520046, -0.02655307948589325, 0.012225031852722168, -0.002520119771361351, 0.01120639406144619, 0.008108100853860378, 0.015492813661694527, 0.0068010869435966015, 0.015752049162983894, -0.011644404381513596, 0.022399067878723145, 0.009515246376395226, -0.0344429686665535, -0.006157643627375364, 0.010883190669119358, -0.009409583173692226, 0.0218682661652565, -0.016455328091979027, 0.009033199399709702, -0.00558607280254364, 0.022649407386779785, -0.017193526029586792, 0.013166015967726707, -0.006563074886798859, -0.0024818694218993187, 0.016454175114631653, -0.014784110710024834, 0.010830800980329514, -0.0048827677965164185, -0.020218724384903908, 0.010935711674392223, 0.007573750801384449, -0.005825722590088844, 0.003859794232994318, 0.004488610662519932, 0.011658919043838978, 0.02141791582107544, -0.029100671410560608, -0.0008160144207067788, -0.009483725763857365, 0.023034363985061646, -0.007616871502250433, -0.000539433560334146, -0.012300048023462296, -0.00020701251924037933, -0.011861087754368782, 0.01758599653840065, -0.002364043379202485, 0.010105106979608536, -0.001455014804378152, 0.00928124412894249, 0.00748042855411768, 0.015334858559072018, 0.005934501998126507, 0.003524049185216427, -0.010620556771755219, -0.007081964984536171, -0.04308149963617325, 0.03721121698617935, 0.0013883743667975068, -0.014038320630788803, -0.0016307283658534288, -0.003094153478741646, -0.009922885335981846, 0.0067621455527842045, 0.0003681257367134094, 0.003093551378697157, -0.017844127491116524, -0.007761604152619839, 0.014650128781795502, -0.009525938890874386, -0.019101368263363838, 0.007167463190853596, -0.01020064577460289, -0.013562473468482494, -0.0007474534213542938, -0.00809221900999546, -0.0028797811828553677, 0.00968794897198677, -0.0019705521408468485, 0.03287078067660332, -0.006936484947800636, 0.005185440182685852, -0.026612455025315285, -0.010951515287160873, -0.010507294908165932, 0.0052900416776537895, -0.030879028141498566, 0.06739970296621323, 0.008495466783642769, -0.010615138337016106, -0.0018708845600485802, -0.011679492890834808, 0.01276627741754055, -0.0066853733733296394, 0.020516840741038322, -0.007566727697849274, -0.0014477751683443785, 0.03802785649895668, -0.014129430055618286, -0.004592873156070709, -0.02206861972808838, 0.023653872311115265, -0.001091790501959622, 0.003457949496805668, -0.006912735290825367, -0.01140198577195406, 0.0020488703157752752, -0.011451762169599533, -0.003467068076133728, -0.008155686780810356, -0.00393659109249711, -0.0034043004270642996, 0.023449795320630074, 0.013923592865467072, 0.0015022115549072623, 0.0011595500400289893, -0.00015008589252829552, -0.004869242664426565, 0.0015715602785348892, -0.007985543459653854, -0.013270002789795399, -0.03372977674007416, -0.006124062463641167, 0.007716501131653786, -0.023133831098675728, -0.0014403548557311296, 0.024761833250522614, -0.013011785224080086, -0.0034886132925748825, 0.001438206061720848, -0.04777250811457634, -0.019013501703739166, 0.013159453868865967, 0.017025571316480637, 0.0006128277163952589, 0.009481918066740036, 0.002515994245186448, 0.005985755939036608, 0.020038288086652756, 0.005135643295943737, -0.011172161437571049, -0.003678254084661603, 0.024518076330423355, 0.022227004170417786, 0.0095905102789402, -0.023224882781505585, 0.012140271253883839, -0.006945093162357807, -0.008195861242711544, -0.015164099633693695, 0.005973810330033302, -0.03844158351421356, -0.013165051117539406, 0.0008254572749137878, -0.003501826897263527, -0.005707315169274807, 0.012260394170880318, -0.0004488896229304373, 0.0027884826995432377, -0.02769746258854866, 0.0049865576438605785, 0.0021370493341237307, 0.03911749646067619, 0.016654280945658684, -0.001911728410050273, 0.005375254899263382, 0.021319344639778137, -0.02307313308119774, -0.0007275886018760502, 0.008104616776108742, 0.0055579738691449165, -0.004021189175546169, -0.009766031056642532, -0.004268238786607981, 0.005633387714624405, -0.019438810646533966, -0.006889525800943375, -0.017498185858130455, 0.006714335177093744, -0.012243498116731644, 0.0020518319215625525, -0.08163941651582718, -0.007596543058753014, 0.0011270451359450817, -0.009279081597924232, 0.010183664038777351, 0.011244354769587517, -0.011410602368414402, 0.0012750347377732396, -0.02441294491291046, 0.01369886752218008, 0.0011245994828641415, 0.005986380390822887, -0.02327745035290718, -0.020380554720759392, 0.013356189243495464, -0.007369409780949354, 0.015523563139140606, 0.004442894831299782, -0.006717263255268335, -0.0019534588791429996, 0.00498390756547451, -0.02764277532696724, 0.03392815589904785, -0.015301533974707127, -0.011103454977273941, 0.008393926545977592, 0.0051812282763421535, -0.004279357846826315, 0.02841208502650261, -0.003946688957512379, -0.014808297157287598, -0.010866294614970684, -0.01565583236515522, -0.009110297076404095, -0.011268753558397293, 0.019666628912091255, -0.020110920071601868, -0.024336066097021103, -0.010874498635530472, -0.01736137457191944, 0.00588031392544508, -0.0037317611277103424, 0.028608687222003937, 0.017347019165754318, 0.0008009194862097502, 0.008950931951403618, -0.011219391599297523, 0.016026677563786507, 0.01446105819195509, -0.0024750898592174053, 0.025968927890062332, -0.0026346142403781414, 0.006115803029388189, 0.010587593540549278, -0.010339722037315369, -0.005539990495890379, 0.025982294231653214, 0.014277489855885506, -0.010941104032099247, -0.0072981445118784904, -0.0030039872508496046, -0.007838563993573189, -0.03489602357149124, 0.011646070517599583, 0.022558286786079407, 0.005440267734229565, 0.009469360113143921, -0.013485137373209, 0.008506366983056068, -0.003756340127438307, -0.010712046176195145, -0.01665794476866722, -0.009198512881994247, 0.0004421629128046334, -0.005959201604127884, -0.01796804554760456, -0.007759168744087219, -0.008830063045024872, -0.04488505423069, 0.006992170587182045, -0.014880320057272911, 0.013390790671110153, 0.024527495726943016, 0.011977583169937134, -0.016336463391780853, 0.01039031334221363, 0.0020575150847434998, 0.016922518610954285, 0.0023093288764357567, -0.019592400640249252, 0.018144691362977028, 0.026515699923038483, 0.014443933963775635, 0.005347350612282753, -0.012377548962831497, 0.014489843510091305, -0.009721736423671246, -0.0051597245037555695, 0.014412984251976013, 0.008693070150911808, -0.009171854704618454, -0.01234179362654686, 0.04990694671869278, -0.013197332620620728, 0.004647859372198582, 0.007574800401926041, 0.004396536387503147, -0.024871012195944786, 0.008165506646037102, -0.0017177148256450891, -0.02625887095928192, 0.02685750275850296, -0.0009819958359003067, 0.030062157660722733, 0.014426148496568203, -0.00795367918908596, -0.021876223385334015, 0.020061958581209183, 0.07298426330089569, 0.009331646375358105, -0.003208168549463153, -0.01258012093603611, 0.01858668401837349, -0.02809189446270466, -0.012772212736308575, 0.008754606358706951, -0.006193449255079031, 0.006870687939226627, 0.009846515022218227, 0.013257138431072235, 0.006399120669811964, -0.01722964271903038, -0.022789794951677322, -0.0032366239465773106, -0.003644888289272785, -0.02362651750445366, -0.0036570013035088778, -0.009123699739575386, 0.014306463301181793, -0.028713533654808998, 0.003593647852540016, 0.033046457916498184, -0.02441571280360222, -0.02276776358485222, 0.014204856008291245, -0.013756321743130684, -0.0033379225060343742, 0.004290674813091755, 0.006666725967079401, 0.008128553628921509, -0.004518480040132999, 0.0009141989285126328, 0.0028457632288336754, 0.0007202315027825534, -0.004485216923058033, 0.0025800075381994247, -0.022009748965501785, -0.00990217737853527, 0.02111629769206047, -0.014942172914743423, 0.009472647681832314, 0.010438473895192146, 0.015580696053802967, 0.008698463439941406, 0.0011892919428646564, -0.01072046346962452, -0.0049746595323085785, 0.019183063879609108, -0.009070465341210365, -0.028334107249975204, 0.011094585992395878, 0.018169112503528595, 0.03697604686021805, -0.015826908871531487, 0.012590248137712479, 0.0021339270751923323, 0.035575248301029205, -0.007767388131469488, -0.006450810469686985, 0.004395437426865101, 0.024169398471713066, -0.005820129066705704, -0.0028892995323985815, -0.015737390145659447, 0.020687874406576157, -0.023065071552991867, 0.007636879570782185, 0.010383788496255875, 0.012560287490487099, -0.017519976943731308, -0.017054269090294838, -0.00900375284254551, -0.007157047279179096, -0.03941228240728378, -0.02958403155207634, -0.03341630473732948, 0.0006954935379326344, 0.0020345975644886494, -0.004812853876501322, -0.01054463628679514, -0.03170422464609146, -0.003930822480469942, 0.03246661275625229, 0.006998378783464432, -0.006707492750138044, -0.07491866499185562, 0.011205403134226799, 0.018635224550962448, -0.0015954963164404035, 0.0012993651907891035, -0.0167742557823658, 0.0023962585255503654, 0.010247273370623589, 0.0006549693644046783, -0.007732552941888571, 0.012073611840605736, -0.027211256325244904, 0.009958397597074509, -0.0059493714943528175, 0.009293617680668831, 0.019357949495315552, 0.021668460220098495, 0.0008496900554746389, 0.0010283391457051039, 0.01954525336623192, -0.02358068898320198, 0.04274763539433479, 0.03304576873779297, 0.011951582506299019, -0.024948744103312492, -0.08172841370105743, -0.019368190318346024, -0.003072883002460003, 0.0016400627791881561, -0.023852147161960602, 0.00669611431658268, 0.01227252185344696, -0.011166990734636784, 0.027233030647039413, -0.011825703084468842, -0.01991250365972519, -0.004623543471097946, -0.0002503247233107686, 0.01972133293747902, -0.002962314523756504, -0.0020984311122447252, 0.009832128882408142, -0.01903599128127098, 0.0241084024310112, 0.008765151724219322, 0.0040381597355008125, 0.011256850324571133, -0.008352508768439293, -0.0037991758435964584, -0.011286361142992973, -0.02328047901391983, 0.004993118345737457, 0.014339662156999111, 0.012465516105294228, 0.011361248791217804, -0.002115964889526367, 0.0032067399006336927, 0.006067034788429737, -0.011703393422067165, -0.0270770862698555, -0.006832892075181007, 0.00701332138851285, -0.006710538174957037, -0.009988036006689072, -0.00508330250158906, -0.006384329404681921, -0.01764804869890213, 0.006515464745461941, -0.016007643193006516, 0.00874470267444849, -0.028525011613965034, 0.007461484521627426, -0.003664356889203191, 0.001026221551001072, 0.02638436295092106, 0.006026384420692921, -0.008625314570963383, 0.01269839983433485, 0.02804976888000965, -0.011623607017099857, 0.028303392231464386, -0.0007669568294659257, 0.011281964369118214, 0.04377041757106781, 0.013264216482639313, -0.01748313568532467, 0.004009700380265713, -0.013514813967049122, 0.07264834642410278, -0.0005968604236841202, 0.0018085932824760675, 0.00512049812823534, 0.0011488288873806596, 0.0015599657781422138, -0.010010682046413422, 0.026261212304234505, 0.01003861054778099, -0.0012998678721487522, 0.021917423233389854, 0.000823549460619688, 0.009647681377828121, 0.009704779833555222, 0.017888827249407768, 0.021108467131853104, -0.011157723143696785, 0.0275520458817482, 0.018856095150113106, 0.0209564957767725, -0.013805367983877659, 0.013630274683237076, -0.0018198592588305473, -0.0009687719866633415, 0.013534542173147202, -0.011925535276532173, 0.006547634489834309, 0.03882421553134918, -0.012632500380277634, -0.007913241162896156, -0.011843699961900711, -0.02686075121164322, 0.003969053737819195, 0.01608971133828163, 0.022155363112688065, -0.0013392373220995069, 0.019209468737244606, 0.0035393228754401207, -0.012460678815841675, 0.015520221553742886, -0.00000670459121465683, -0.024977149441838264, 0.0036892348434776068, -0.015258440747857094, 0.0025213630869984627, 0.011211125180125237, 0.0058058747090399265, -0.0006125536747276783, 0.015672074630856514, -0.004202359821647406, 0.018203241750597954, 0.009137925691902637, -0.012241228483617306, 0.018209945410490036, 0.0019532996229827404, 0.028859730809926987, 0.0013528119307011366, 0.00042269937694072723, 0.003237964818254113, -0.0009789243340492249, 0.003969445824623108, -0.011019442230463028, -0.008199414238333702, 0.0037558237090706825, 0.014727171510457993, -0.003009563311934471, 0.006689960137009621, -0.017682721838355064, -0.002930730814114213, 0.014414658769965172, -0.02266876772046089, -0.008077380247414112, 0.00377417029812932, 0.007829776965081692, -0.004901824053376913, 0.001284969155676663, -0.004974649287760258, -0.006772905122488737, 0.013973146677017212, -0.0037810769863426685, -0.010711035691201687, -0.0013433580752462149, -0.014781616628170013, -0.010514269582927227, 0.01578880101442337, -0.008317148312926292, -0.013656415045261383, 0.004487492144107819, -0.0017369040288031101, 0.0068536545149981976, 0.038772016763687134, 0.023490795865654945, 0.004389381967484951, 0.000551906879991293, 0.011177685111761093, 0.033066462725400925, -0.018558617681264877, 0.012101630680263042, 0.017677992582321167, 0.001915395027026534, 0.033386990427970886, 0.010172578506171703, 0.02649732306599617, 0.0049284957349300385, -0.011574395932257175, -0.0020355097949504852, 0.02874842844903469, 0.007458625361323357, 0.0068227024748921394, 0.000058976467698812485, 0.019098682329058647, 0.012719875201582909, 0.00995941087603569, -0.007704572752118111, -0.0085863396525383, 0.010739509016275406, -0.011439066380262375, -0.00852469727396965, -0.023100536316633224, -0.005866514518857002, -0.011836376041173935, -0.011920681223273277, 0.058472566306591034, 0.030322253704071045, -0.014396880753338337, -0.016437934711575508, -0.0049817366525530815, 0.03193943202495575, -0.02133466675877571, 0.004233320709317923, 0.011872399598360062, -0.023113593459129333, 0.010171988978981972, 0.003832667600363493, 0.014341099187731743, 0.010625481605529785, 0.0037815142422914505, 0.004950539208948612, -0.01030695904046297, 0.01951099932193756, 0.030173547565937042, 0.0010335431434214115, 0.012470254674553871, 0.02603033557534218, 0.005711302161216736, -0.010652568191289902, 0.01569671370089054, -0.01776830106973648, -0.002724979305639863, 0.002085728570818901, 0.013706006109714508, -0.001259279204532504, 0.01631370559334755, -0.009267770685255527, -0.040518276393413544, 0.009128978475928307, -0.00022985623218119144, -0.0021976293064653873, 0.009950042702257633, 0.017659056931734085, -0.0041325893253088, -0.001956032821908593, -0.01637577824294567, 0.01741490140557289, 0.02204558625817299, 0.0024261169601231813, -0.004681937396526337, 0.0024599891621619463, -0.003728372510522604, 0.013281403109431267, 0.015511399134993553, 0.020032398402690887, -0.026926659047603607, 0.025175487622618675, -0.007753594778478146, -0.015646958723664284, 0.002533565741032362, 0.006016522645950317, -0.013246690854430199, -0.0007584942504763603, 0.005595982540398836, 0.010688722133636475, 0.0027969845104962587, -0.009094106033444405, 0.00007035722956061363, 0.0072156828828155994, -0.012101887725293636, 0.013193976134061813, -0.008090151473879814, 0.014221660792827606, -0.015208197757601738, -0.0009959004819393158, -0.006671887822449207, -0.016223527491092682, 0.01158458087593317, -0.004469036590307951, -0.007418901659548283, 0.009438111446797848, 0.01863977685570717, -0.020383944734930992, -0.024134492501616478, -0.0055195968598127365 ]
[ 0.3416993319988251, -0.2764573395252228, 0.07109677046537399, -0.09265810996294022, -0.21181832253932953, 0.12714579701423645, -0.0011476232903078198, -0.03925899788737297, -0.05564015358686447, -0.7759559750556946, -0.39923882484436035, 0.07596547156572342, -0.40554100275039673, -0.027238918468356133, -0.1841575652360916, 0.6631033420562744, -0.09952094405889511, 0.11643122881650925, -0.1536608636379242, -0.15765804052352905, -0.004249880090355873, -0.45726412534713745, 0.04779016971588135, -0.5324684381484985, 0.30395495891571045, 0.26729556918144226, 0.5822464823722839, 0.4258163273334503, -0.2484418898820877, 0.11573713272809982, -0.4205872118473053, -0.10574480891227722, 0.15404143929481506, -0.10812985152006149, -0.03277293220162392, -0.1442967802286148, -0.3889731466770172, 0.45743420720100403, 0.124066062271595, -0.4394925832748413, -0.28210484981536865, -0.43891504406929016, -0.12694796919822693, 0.4719250500202179, -0.06252068281173706, -0.5394852757453918, -1.0512866973876953, 0.16867826879024506, -0.8956511616706848, 0.07230828702449799, -0.11992940306663513, 0.8747707009315491, -0.042796190828084946, 0.16746403276920319, -0.06825871020555496, 0.29397881031036377, -0.17532922327518463, -0.42732906341552734, 0.28219181299209595, 0.31684568524360657, 0.25876325368881226, -0.014007032848894596, 0.1126239225268364, 0.7985253930091858, -0.3072719871997833, 0.08794306218624115, -0.3045039176940918, -0.08586371690034866, -0.24655583500862122, -0.3620009124279022, 0.22726677358150482, 0.027040686458349228, -0.47208184003829956, 0.44287577271461487, -0.09467144310474396, -0.10388784110546112, -0.10338619351387024, 0.26343655586242676, 0.12386788427829742, 0.30282166600227356, -0.10307445377111435, 0.2320537567138672, 0.42186617851257324, -0.0684656873345375, 0.3327542841434479, 0.17665213346481323, -0.22507508099079132, 0.1683489978313446, -0.5349625945091248, 0.42433586716651917, 0.34017008543014526, -0.24638178944587708, 0.15462252497673035, 0.1366523802280426, 0.2803153097629547, -0.03490684926509857, -0.4999244511127472, -0.17742061614990234, 0.23371538519859314, 0.1422874927520752, -0.31519651412963867, 0.3942245841026306, 0.16017462313175201, -0.46080273389816284, -0.09977000206708908, -0.2501167356967926, -0.5699319243431091, -0.5814983248710632, -0.09715329855680466, 0.12537547945976257, -0.4108605980873108, 0.1885199099779129, 0.19797846674919128, -0.08241330832242966, -0.28428494930267334, 0.4484599828720093, 0.0765814408659935, -0.2934510111808777, -0.08045335114002228, 0.21812839806079865, 0.06027541682124138, 1.1115492582321167, 0.6853190660476685, 0.5116335153579712, 0.16296380758285522, 0.28038403391838074, 0.7817336916923523, 0.2512533366680145, -0.295716792345047, 0.7138683199882507, 0.20496568083763123, 0.46648338437080383, -0.04994785040616989, 0.10720081627368927, -0.12015554308891296, -0.21290920674800873, 0.341900497674942, -0.10618633031845093, 0.40266674757003784, 0.1721867024898529, -0.7703378796577454, -0.55487060546875, -0.06596586853265762, -0.22554877400398254, 0.2003471702337265, -0.2698987126350403, -0.31976115703582764, -0.49888402223587036, -0.966468870639801, 0.2726283073425293, 0.32309791445732117, -0.17419104278087616, -0.22102169692516327, -0.39824461936950684, -0.33071842789649963, 0.8201881647109985, 0.4102219343185425, 0.21204495429992676, -0.46261268854141235, 0.31118685007095337, 0.767964780330658, 0.8160531520843506, -0.3201434314250946, -0.8297125101089478, 0.04969574138522148, -0.5772818922996521, 0.019493456929922104, 0.25998979806900024, 0.14164014160633087, -0.2999841868877411, -0.07048560678958893, -0.059261761605739594, 0.22188657522201538, -0.2966187596321106, -0.2577407658100128, 0.4767819046974182, 0.34028005599975586, 0.21317355334758759, 0.49938297271728516, -0.0622340552508831, -0.4278327524662018, -0.22844298183918, 0.20521409809589386, -0.551579475402832, 0.21789368987083435, -0.06622068583965302, 0.6771267056465149, -0.04971138387918472, -0.08582409471273422, -0.07687956094741821, -1.119083285331726, -0.43853089213371277, 0.25243809819221497, -0.5818161964416504, 0.9893847107887268, -0.19797222316265106, -0.40206626057624817, 1.4557162523269653, -0.13351796567440033, 0.41286537051200867, -0.36040204763412476, 0.36914002895355225, 0.5453011989593506, -0.4719652235507965, 0.020056866109371185, -0.29675808548927307, -0.03735439106822014, -0.06472606211900711, -0.5630402565002441, 0.16453860700130463, 0.031047549098730087, -0.1651393473148346, -0.24828292429447174, 0.011356870643794537, 0.45976850390434265, 0.0776820033788681, -0.14191797375679016, -0.24033834040164948, 0.16837178170681, -0.1956924945116043, 0.9015709161758423, -0.3402213752269745, -0.21998834609985352, 0.2239214926958084, -0.335997998714447, 0.5036376118659973, 0.4449089467525482, 0.5040193200111389, 0.6115911602973938, -0.15622766315937042, -0.138762429356575, 0.07292674481868744, 0.36807528138160706, -0.7024551630020142, -0.1105513721704483, -0.3514014482498169, 0.10037925839424133, 0.07332417368888855, 0.22908097505569458, 0.32338374853134155, 0.163845032453537, 0.7175976634025574, 0.09093234688043594, -0.5665436387062073, -0.220769464969635, -0.4172210693359375, -0.021935733035206795, -0.15910457074642181, -0.35151299834251404, 0.02537243254482746, -0.1813908815383911, 0.4269126355648041, 0.0990513488650322, -0.09385409206151962, -0.4801607131958008, 0.4818747937679291, 0.2104731798171997, -0.6558080911636353, -0.5324512720108032, 0.2966699004173279, -0.19931942224502563, -0.14041028916835785, -0.1001286506652832, 0.05217736214399338, 0.33152875304222107, -0.9842139482498169, -0.33898136019706726, -0.5182051658630371, 0.3188740611076355, 0.9212960004806519, 0.5232437252998352, -0.02615959197282791, -0.40313419699668884, 0.20811471343040466, -0.12516319751739502, -1.1687818765640259, 0.5923336148262024, 0.1879742592573166, -0.4072053134441376, -0.45484012365341187, 0.3644386827945709, 0.23546592891216278, 1.0651838779449463, -0.10442067682743073, -0.31749412417411804, -0.43061429262161255, 0.33226338028907776, 0.23701974749565125, -0.6336145997047424, 0.09868317097425461, -0.13268916308879852, 1.0856273174285889, -0.18707160651683807, -0.5073195099830627, 0.3813328444957733, 0.37865281105041504, 0.45881491899490356, 0.14075487852096558, 0.1545831710100174, -0.10113079100847244, -0.3050483167171478, 0.0011568517656996846, 0.14287777245044708, -0.333299845457077, 0.4899377226829529, -0.06571945548057556, -0.34856346249580383, 0.1869346648454666, -5.877597808837891, -0.27955588698387146, -0.8188333511352539, -0.4831547737121582, 0.030942562967538834, 0.04573481157422066, 0.7874582409858704, -0.3070943355560303, 0.1710304617881775, -0.6889829635620117, 0.42475926876068115, -0.06979174166917801, 0.17317812144756317, 0.3186260461807251, 0.21525011956691742, 0.4324221611022949, 0.37762975692749023, 0.5745296478271484, 0.8530365228652954, 0.4169255495071411, 0.29604974389076233, -0.6470627784729004, -0.3202946186065674, 0.5693888664245605, 0.08497494459152222, 0.4091886281967163, -0.9617978930473328, 0.25815024971961975, 0.21523864567279816, -0.14700253307819366, 0.32600823044776917, -0.5810181498527527, -0.42380014061927795, -0.030105866491794586, -0.2032359093427658, -0.16278359293937683, 0.1436874270439148, 0.09223547577857971, -0.0322086326777935, -0.13491392135620117, 0.6663854122161865, 0.29538217186927795, 0.3101784884929657, -0.14181992411613464, 0.10511160641908646, -0.14179727435112, -0.25815775990486145, 0.567214846611023, 0.5670984983444214, 0.5328312516212463, -0.22788825631141663, -0.14344100654125214, -0.116266630589962, 0.09063717722892761, -0.2884223759174347, -0.155020073056221, 0.2660527527332306, 0.5040218234062195, -0.11717716604471207, 0.30490490794181824, 0.5084444284439087, -0.9853511452674866, 0.3372989296913147, -0.9711806178092957, -0.4257694482803345, 0.6046039462089539, -0.3593999445438385, -0.34563225507736206, 0.05647691339254379, 0.4185904264450073, -0.22967736423015594, -0.09593130648136139, -0.3119620680809021, -0.42789098620414734, 0.5899078249931335, -0.45754915475845337, 0.3838701844215393, -0.06947881728410721, -0.306424617767334, -0.10812835395336151, -0.26379719376564026, -0.7954370379447937, 0.508175790309906, -0.05582242086529732, 0.19186826050281525, -0.18918481469154358, -0.02560172788798809, -0.3228716552257538, -0.31860920786857605, 0.10443660616874695, 0.44881877303123474, -0.9935076832771301, 0.21044516563415527, 0.34199440479278564, 0.7960192561149597, -0.18743941187858582, 0.7345341444015503, 0.07789312303066254, 0.5964879989624023, -0.2260158509016037, 0.18183347582817078, -0.03812113031744957, 0.19083134829998016, -0.9670838713645935, -0.4069333076477051, 0.2063537836074829, -0.40629541873931885, 0.20027786493301392, 0.6983181834220886, -0.35341131687164307, -0.09831269085407257, -0.15048891305923462, 0.07597572356462479, 0.03814288601279259, 0.29216042160987854, -0.023585733026266098, 0.17158977687358856, -0.09222123771905899, -0.0881236344575882, 0.1443571150302887, -0.3925175666809082, -0.3087349832057953, -0.6904265284538269, 0.29811379313468933, 0.2903847396373749, -0.7138977646827698, 0.40385308861732483, 0.18103638291358948, -0.03132443502545357, -0.16958992183208466, 0.48477450013160706, 0.22775696218013763, -0.07765685766935349, -0.05302409082651138, 0.5061621069908142, -0.5421030521392822, -0.04599565267562866, 0.3349437117576599, 0.37318867444992065, -0.5415849685668945, 0.17366214096546173, -0.13016916811466217, -0.11106152087450027, 0.45173415541648865, -0.16730251908302307, 0.11834258586168289, 0.3043617606163025, 0.022736363112926483, -0.05801188945770264, -0.08075959235429764, 0.11633674055337906, 0.21896277368068695, -0.032297804951667786, 0.09515947103500366, -0.13766410946846008, 0.03650576248764992, 0.10137954354286194, 0.1490323841571808, 0.2608258128166199, -0.6144808530807495, -0.06955727189779282, -0.050167616456747055, -1.0023198127746582, 0.20937161147594452, -0.3959844708442688, -0.21130889654159546, -0.10146690905094147, -0.1806844025850296, -0.12194090336561203, 0.13754867017269135, -0.4748615324497223, -0.1603430211544037, 0.5552003979682922, -0.3423032760620117, -0.0671747475862503, 0.01540936529636383, 0.46424955129623413, -0.012044895440340042, -0.05428298935294151, 0.3524130582809448, -0.639393150806427, -0.18534357845783234, 0.05555998161435127, 0.38585740327835083, 0.13728787004947662, -0.09586933255195618, -0.37514370679855347, 0.34681132435798645, -0.15826798975467682, -0.531916081905365, 0.11755073815584183, 0.3323097825050354, 0.3028721511363983, -0.2755863070487976, -0.1269148290157318, -0.19989870488643646, 0.7927862405776978, 0.3329530656337738, 0.12646792829036713, -0.5287697911262512, 0.1485079824924469, 0.31094422936439514, -0.4144579768180847, 0.7728860378265381, 0.16037215292453766, -0.15342839062213898, 0.018713003024458885, 0.37464427947998047, 0.12786363065242767, -0.6482784152030945, -0.5550992488861084, -0.5623506903648376, -0.002290361560881138, 0.3814893960952759, -0.28851062059402466, -0.007959243841469288, 0.12158185243606567, -0.11536509543657303, -0.048760417848825455, 0.05024692788720131, -0.050884947180747986, -0.3468746840953827, -0.14149673283100128, 0.30242905020713806, -0.3997410833835602, 0.2519780099391937, 0.7996770143508911, -0.9386925101280212, 0.01420868095010519, 0.053067825734615326, 0.44822099804878235, -0.1637902706861496, 0.08702725172042847, 0.27391815185546875, -0.2947954833507538, -0.5117551684379578, -0.9996649622917175, -0.19174844026565552, 0.16266626119613647, -0.23765528202056885, -0.36782312393188477, 0.4601474106311798, 0.028651900589466095, -0.3262387216091156, -0.3666307330131531, 0.2271355390548706, -0.04598824307322502, -0.6399492025375366, -0.3472244143486023, 0.4125388562679291, 0.4399968385696411, -0.2300766557455063, -0.19590160250663757, 0.018100563436746597, 0.869979977607727, 0.6947974562644958, -0.6822496056556702, -0.3084214925765991, -0.3702303469181061, 0.4422151446342468, 0.2520773112773895, 0.152114138007164, -0.6227439641952515, -0.26503705978393555, 0.35834985971450806, -0.35573533177375793, -0.015215774066746235, -0.5746479630470276, 0.3881665766239166, -0.2313259243965149, -0.4726179242134094, -0.1400652527809143, 0.14931245148181915, 0.9070577025413513, 0.029954394325613976, -0.45261454582214355, -0.052393391728401184, -0.031335022300481796, 0.07674533873796463, 0.5151441693305969, -0.4249907433986664, -0.41897234320640564, 0.45321640372276306, -0.24275971949100494, 0.16996507346630096, -0.3122999966144562, 0.19630274176597595, 0.06959060579538345, 0.06551679968833923, -0.03484730422496796, -0.44450047612190247, 0.6754700541496277, -0.4161139130592346, -0.3520931899547577, -0.5918775796890259, 0.40843459963798523, 0.7167513966560364, 0.25113818049430847, 0.10142892599105835, -0.28158020973205566, 0.015586757101118565, 0.7156334519386292, 0.7818028330802917, -0.32953372597694397, 0.06852930039167404, -0.017075516283512115, -0.10524960607290268, 0.20902495086193085, -0.18222667276859283, 0.45732492208480835, 0.42549481987953186, -0.1780766397714615, 0.48435676097869873, 0.27308133244514465, -0.4818762540817261, -0.2115660309791565, -0.19004452228546143, -0.255873441696167, 0.7559773325920105, -0.03914939612150192, 0.08598227053880692, 0.6235973834991455, 0.40262144804000854, -0.21762391924858093, -0.3867802917957306, 0.4173263609409332, 0.1695035696029663, 0.2362053394317627, 0.3102495074272156, 0.04628734663128853, 0.3578944802284241, 0.31841227412223816, 0.0056516448967158794, -0.0598028302192688, -0.2261892557144165, 0.1111278235912323, 0.23518304526805878, -0.31050440669059753, 0.1233462244272232, 0.1106901466846466, 0.20984593033790588, 0.16064347326755524, -0.2166357785463333, -0.030475184321403503, -0.344227135181427, -0.27428075671195984, 0.14886018633842468, 0.3829525411128998, -0.2005641758441925, 0.5839836001396179, -0.1548638641834259, 0.021653570234775543, 0.07904338836669922, -0.10966046154499054, 0.1180630475282669, -0.12366169691085815, 0.5395322442054749, -0.03318273648619652, -0.23460666835308075, 0.0785645842552185, 0.0971803218126297, 0.8568865060806274, -0.2637498378753662, 0.1984546035528183, -0.9866308569908142, -0.4017777740955353, 0.49975472688674927, -0.13715428113937378, 0.14689378440380096, -0.23699283599853516, -0.30036190152168274, 0.4369710087776184, -0.43496009707450867, 0.7335817217826843, -0.14150717854499817, -0.40367865562438965, 0.28992384672164917, -0.03848804160952568, -0.2974449396133423, 0.5161406993865967, 0.17961452901363373, -0.22812707722187042, 0.06251666694879532, -0.428984671831131, 0.4493296146392822, -0.2866438031196594, 0.10851539671421051, -0.13792727887630463, -0.013115382753312588, -0.24651974439620972, 0.173289954662323, -0.5091903209686279, 0.2760993242263794, -0.22727979719638824, -0.06113637238740921, -0.032574765384197235, -0.47681593894958496, 0.9361259937286377, 0.4117869436740875, 0.2649797201156616, -0.06960784643888474, 0.3267107307910919, 0.06126338243484497, 0.7922967076301575, 0.08376583456993103, 0.16604946553707123, -0.5614845156669617, 0.13911010324954987, -1.1578229665756226, 0.17411644756793976, 0.36487165093421936, 0.14838895201683044, -0.07888482511043549, -0.036385808140039444, 0.23440876603126526, -0.30778518319129944, -0.07270202040672302, -0.5217864513397217, 0.40859705209732056, 0.11933262646198273, 0.016596343368291855, -0.7268136143684387, 0.3161948025226593, 0.39777758717536926, -0.5489200949668884, 0.07503724098205566, 0.24367675185203552, 0.5619009733200073, -0.5422167778015137, 0.45347002148628235, 0.24410933256149292, -0.3444359600543976, -0.03647281974554062, 0.5988587141036987, -0.6835355758666992, 0.06106480583548546, -0.21437720954418182, 0.6832291483879089, 0.3646945059299469, -0.6522868871688843, -0.3324485421180725, -0.27957507967948914, -0.29389551281929016, -0.14132152497768402, -0.15763820707798004, 0.5150290727615356, -0.48516184091567993, -0.7357998490333557, -1.4071484804153442, 0.814261257648468, 0.21332727372646332, -0.1817084103822708, -0.281593382358551, -0.31920626759529114, -0.3206164538860321, 0.02924320101737976, -0.23674336075782776, -0.2966207265853882, 0.08637268841266632, -0.22991593182086945 ]
Polymerization of actin filaments directed by the actin-related protein (Arp)2/3 complex supports many types of cellular movements. However, questions remain regarding the relative contributions of Arp2/3 complex versus other mechanisms of actin filament nucleation to processes such as path finding by neuronal growth cones; this is because of the lack of simple methods to inhibit Arp2/3 complex reversibly in living cells. Here we describe two classes of small molecules that bind to different sites on the Arp2/3 complex and inhibit its ability to nucleate actin filaments. CK-0944636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-0993548 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes. Two inhibitors with different mechanisms of action provide a powerful approach for studying the Arp2/3 complex in living cells.
[ -0.005124233663082123, 0.010736597701907158, -0.025718051940202713, 0.012325777672231197, -0.014106889255344868, -0.0031279015820473433, 0.012620970606803894, 0.0068505145609378815, -0.018834535032510757, -0.027911294251680374, -0.0047544757835567, 0.011835060082376003, -0.031793203204870224, 0.019403532147407532, -0.007365596480667591, 0.023893479257822037, 0.000531072961166501, -0.019507743418216705, 0.005803998559713364, -0.015817763283848763, 0.00828529242426157, -0.007706281263381243, 0.01214990671724081, -0.013124503195285797, -0.026614494621753693, -0.012309244833886623, 0.022065557539463043, -0.027827635407447815, 0.00797388143837452, 0.007243551313877106, 0.03569374606013298, -0.004824680741876364, -0.003023474244400859, -0.006088776048272848, -0.005701703019440174, 0.015622192993760109, -0.0031265788711607456, 0.03362475708127022, 0.02173118107020855, -0.0047074416652321815, -0.005032360553741455, -0.014333300292491913, 0.0012751647736877203, -0.0076985955238342285, -0.010937037877738476, -0.012480009347200394, 0.00000853993697091937, 0.006156800780445337, -0.008031297475099564, -0.003964836709201336, 0.0017949144821614027, -0.0237693153321743, -0.017137937247753143, 0.029725169762969017, -0.006936926860362291, -0.026266222819685936, 0.021169237792491913, -0.018526628613471985, -0.012687877751886845, -0.013033375144004822, -0.0021835784427821636, 0.04318451136350632, -0.0004495331086218357, -0.041180338710546494, 0.010609336197376251, -0.06567883491516113, 0.03849000856280327, 0.013372700661420822, 0.0055128540843725204, -0.004033820703625679, -0.01195839699357748, 0.006702899932861328, 0.01241383794695139, -0.0047467113472521305, -0.029449239373207092, 0.000548437237739563, 0.0068093230947852135, -0.003147345967590809, -0.0034151615109294653, 0.01674642600119114, -0.022573696449398994, -0.03338724374771118, 0.027334783226251602, 0.004975380375981331, 0.0014205032493919134, 0.018439698964357376, -0.014496413990855217, 0.0015924768522381783, -0.004660151898860931, 0.013775670900940895, 0.014933932572603226, 0.016020188108086586, 0.018082482740283012, -0.007463798858225346, 0.009483392350375652, -0.0053297383710742, 0.005644337739795446, -0.05559628829360008, 0.009935962967574596, -0.014175454154610634, -0.03193411976099014, 0.009232722222805023, 0.021028675138950348, -0.01284405030310154, 0.006403366103768349, 0.008654240518808365, 0.01748529076576233, 0.016124766319990158, 0.05698440968990326, 0.014672205783426762, -0.008235516957938671, 0.012361034750938416, -0.016647180542349815, 0.01731942780315876, -0.010107496753334999, 0.010512611828744411, -0.00032633915543556213, 0.04017876461148262, 0.01656264439225197, 0.020572137087583542, 0.030148945748806, 0.014620236121118069, -0.005507603753358126, 0.0036727688275277615, 0.004871918819844723, 0.003016609698534012, 0.0014635191764682531, 0.0008845115080475807, 0.01621113158762455, 0.0343477800488472, -0.011544615030288696, 0.011353135108947754, 0.01781819947063923, 0.024498477578163147, -0.01449695322662592, 0.0048603517934679985, 0.020534750074148178, -0.009824623353779316, -0.0001168479211628437, 0.006322360597550869, 0.02638745680451393, 0.008796845562756062, 0.007048104889690876, 0.027711864560842514, 0.02885456383228302, 0.01104357372969389, -0.011114062741398811, 0.016000699251890182, 0.008217345923185349, -0.01746029034256935, 0.0014599880669265985, 0.020884595811367035, -0.01400686614215374, -0.010354452766478062, 0.010748145170509815, 0.04283050075173378, -0.012419183738529682, 0.004309974145144224, -0.0187697634100914, -0.003616162110120058, -0.01686490699648857, -0.010333653539419174, 0.012628315016627312, 0.011471685022115707, -0.03339704871177673, -0.007782365195453167, 0.0002003377303481102, -0.01628306694328785, -0.015591230243444443, 0.0036516357213258743, -0.004953095689415932, 0.004096120595932007, 0.011929037980735302, 0.003101089969277382, -0.0002648353110998869, 0.006037005223333836, 0.005820679944008589, 0.005815879907459021, -0.030978333204984665, 0.06545817106962204, 0.019626140594482422, 0.0008333658333867788, 0.006779837887734175, 0.029625602066516876, 0.01112357247620821, -0.00550671573728323, 0.004717553500086069, -0.0037183118984103203, 0.010865423828363419, -0.02217741683125496, -0.007801387924700975, -0.0118485689163208, -0.006515619345009327, 0.00450151925906539, -0.032504986971616745, 0.0033790927845984697, 0.013486393727362156, -0.00413424801081419, 0.0033347979187965393, 0.0067189582623541355, -0.0002454333007335663, -0.016619041562080383, 0.02770359069108963, -0.012396089732646942, -0.012043479830026627, -0.00776381092146039, -0.0036877745296806097, -0.009367100894451141, 0.019184717908501625, 0.020498406141996384, 0.028019234538078308, -0.04289238899946213, -0.022896911948919296, -0.017261061817407608, -0.005944457370787859, 0.000023428117856383324, -0.0037583038210868835, -0.03032447025179863, -0.02908753976225853, -0.014659336768090725, 0.006239620037376881, 0.003114706138148904, 0.010320439003407955, -0.011740129441022873, 0.021568192169070244, -0.0063101607374846935, 0.006929901894181967, 0.020086221396923065, 0.02772580087184906, 0.012531505897641182, 0.006659306585788727, -0.043447427451610565, -0.015290231443941593, -0.004384839907288551, 0.004711636807769537, -0.008348674513399601, 0.015863927081227303, -0.029190940782427788, 0.025161374360322952, -0.006013768725097179, -0.004557127133011818, 0.006224755197763443, 0.03480512276291847, -0.02663949504494667, 0.03516621142625809, -0.018665580078959465, 0.007287248037755489, 0.004357310943305492, 0.0012285411357879639, -0.03261104226112366, 0.009776508435606956, -0.01236753724515438, -0.00020773708820343018, 0.006424404680728912, -0.044728633016347885, -0.025215044617652893, -0.015719274058938026, 0.01992771029472351, 0.027171563357114792, -0.007891380228102207, -0.007700634188950062, 0.005469908006489277, -0.008279930800199509, -0.00015861401334404945, -0.03102775290608406, 0.005494019016623497, 0.000548425130546093, 0.02436811290681362, -0.005984004586935043, -0.013091068714857101, 0.012415695935487747, -0.0114801786839962, -0.003256881143897772, -0.0807076171040535, -0.01760197803378105, -0.013022398576140404, -0.009418582543730736, 0.007294570095837116, -0.0026841596700251102, -0.0017140451818704605, 0.0008184970356523991, -0.024937007576227188, 0.0009669503197073936, 0.021191570907831192, -0.0030686836689710617, -0.009579210542142391, -0.015279109589755535, -0.0006657014600932598, -0.01576194539666176, 0.01466349232941866, 0.003682293463498354, -0.03939381241798401, -0.0355745330452919, -0.006477731745690107, -0.03793436288833618, -0.0145779550075531, -0.0007988434517756104, -0.006755958776921034, 0.0005299728363752365, -0.01802162453532219, 0.00027165235951542854, -0.02934098057448864, 0.017809400334954262, -0.02627110481262207, -0.011689011938869953, -0.04765329882502556, -0.00017577316612005234, 0.011527711525559425, 0.018406443297863007, -0.023565547540783882, -0.019559137523174286, -0.020676739513874054, 0.025393150746822357, -0.010817956179380417, 0.0038626883178949356, 0.013710498809814453, 0.016547048464417458, 0.01568528264760971, 0.01583503931760788, 0.013871372677385807, -0.015629492700099945, 0.021200254559516907, -0.006293050013482571, -0.019528396427631378, 0.008433609269559383, 0.006194114685058594, 0.021731574088335037, -0.011553547345101833, 0.02443944849073887, 0.008940305560827255, -0.0038898224011063576, -0.011391526088118553, -0.008969852700829506, -0.004382758401334286, 0.01798856258392334, 0.021150901913642883, 0.017527882009744644, -0.04691217839717865, 0.010381081141531467, 0.025626428425312042, -0.0014610872603952885, -0.013824252411723137, 0.016377393156290054, 0.01962868869304657, 0.01694411411881447, -0.0119894128292799, 0.00015988340601325035, -0.004818511661142111, -0.01803213730454445, -0.017052292823791504, -0.024486703798174858, -0.00434759259223938, -0.004670501686632633, -0.007571493741124868, 0.006982601247727871, 0.01834402233362198, 0.007405939977616072, -0.02138596400618553, -0.04954500123858452, 0.006409334018826485, 0.0024362639524042606, 0.01918012835085392, -0.02360326051712036, -0.00751025415956974, 0.019907785579562187, 0.006406188942492008, 0.008343247696757317, -0.026440057903528214, -0.008428791537880898, 0.007235219702124596, 0.0018045910401269794, 0.003907328937202692, 0.010585097596049309, -0.013025647029280663, 0.007400397211313248, 0.021600279957056046, -0.006921033374965191, -0.015400219708681107, 0.012723635882139206, -0.020598871633410454, -0.004940417595207691, -0.008389700204133987, -0.0003997373569291085, -0.007864244282245636, 0.003294610418379307, -0.00025621254462748766, 0.029617881402373314, 0.01227461826056242, 0.006249841768294573, -0.018931837752461433, 0.006675275042653084, 0.07100768387317657, -0.0039121247828006744, -0.00594066409394145, -0.011658119037747383, 0.016777638345956802, -0.03066186048090458, 0.008274612948298454, 0.03887249156832695, -0.0010229781037196517, 0.006538938730955124, 0.014637756161391735, -0.0058490196242928505, -0.005965736228972673, 0.030251288786530495, -0.0245308019220829, -0.01914840377867222, -0.003540707752108574, -0.010467199608683586, 0.05080311745405197, 0.04815059155225754, -0.016875214874744415, -0.034880898892879486, 0.012385847046971321, -0.04586934298276901, -0.006973625626415014, -0.03256313502788544, -0.015752289444208145, -0.01213535014539957, -0.008561329916119576, 0.004495257046073675, 0.0010597328655421734, -0.014653990976512432, -0.009318720549345016, 0.003263176651671529, 0.02220650017261505, 0.0018708083080127835, 0.05835191160440445, -0.010968746617436409, -0.01068592444062233, -0.014308182522654533, -0.00013703852891921997, -0.015574086457490921, 0.042554501444101334, 0.020047828555107117, -0.006447636056691408, 0.023901423439383507, -0.002939186990261078, -0.005391132552176714, -0.008719945326447487, 0.016896750777959824, -0.030401214957237244, -0.00255414517596364, 0.01733657345175743, -0.03863353654742241, 0.021258998662233353, -0.023210033774375916, 0.040841490030288696, -0.009964248165488243, -0.01635589450597763, 0.0012475545518100262, -0.01748661883175373, 0.010550050064921379, 0.03560445085167885, -0.02285478264093399, -0.012868333607912064, -0.027182158082723618, -0.01094268262386322, -0.020064102485775948, -0.007252153009176254, -0.002079765312373638, 0.004189193248748779, 0.020806510001420975, -0.012349861674010754, -0.0005799157079309225, -0.03270690143108368, -0.008380703628063202, 0.007477027364075184, 0.0029259035363793373, 0.05605126544833183, -0.023299019783735275, 0.015000425279140472, 0.024879779666662216, 0.008476963266730309, -0.02391079254448414, 0.011617269366979599, -0.017413267865777016, -0.023771531879901886, -0.07377813011407852, -0.0052470918744802475, -0.01960808038711548, -0.009148713201284409, -0.014403881505131721, 0.010453367605805397, -0.019746024161577225, -0.03629530966281891, 0.019124044105410576, -0.0047149816527962685, -0.013339944183826447, 0.009184049442410469, -0.018868442624807358, 0.0027004762087017298, 0.012867610901594162, -0.026286430656909943, -0.027635805308818817, 0.004135370720177889, 0.0049615660682320595, -0.017765939235687256, -0.005629903636872768, -0.017520466819405556, -0.027833640575408936, -0.014591073617339134, 0.0009813790675252676, -0.0801222175359726, -0.01400347612798214, 0.011360914446413517, -0.008372711949050426, 0.003183928085491061, -0.014011424966156483, 0.038045577704906464, -0.0067129917442798615, -0.023652466014027596, -0.021800460293889046, -0.011954807676374912, 0.024730371311306953, -0.02917030081152916, 0.0005690250545740128, -0.0013044469524174929, -0.007512043230235577, 0.0018642947543412447, 0.013200006447732449, -0.02914690412580967, 0.0494990199804306, -0.011838792823255062, 0.03738712891936302, -0.014773894101381302, -0.012691710144281387, -0.011256587691605091, -0.017480231821537018, 0.003700442612171173, 0.018858129158616066, -0.011587928980588913, -0.061255570501089096, -0.01210654154419899, -0.012196438387036324, -0.008211130276322365, -0.03392621502280235, 0.011106266640126705, -0.01988384686410427, -0.0014244713820517063, -0.002923745196312666, -0.002038460923358798, -0.02341359667479992, -0.00882616825401783, 0.015538403764367104, -0.01750480942428112, 0.002325933426618576, -0.013760705478489399, -0.01972588710486889, 0.0041689183562994, -0.008872997015714645, 0.024694059044122696, -0.001842973753809929, 0.010321097448468208, -0.006926837842911482, -0.002983242506161332, 0.025763772428035736, 0.040916163474321365, -0.0024369079619646072, -0.009298433549702168, 0.003724202513694763, 0.030367160215973854, 0.001758394530043006, 0.004746170714497566, -0.012669220566749573, 0.011782724410295486, 0.07031308114528656, -0.0016267313621938229, -0.006818666122853756, -0.008315907791256905, 0.005827563349157572, 0.004083036445081234, 0.008095948956906796, -0.02705719694495201, 0.016710229218006134, -0.02997397445142269, -0.00265581626445055, -0.0241367407143116, 0.000574055127799511, 0.01856089197099209, -0.018315721303224564, -0.009258735924959183, -0.020998302847146988, 0.018214328214526176, -0.01280137151479721, 0.01902141235768795, 0.0036838168743997812, -0.005748467054218054, -0.013427194207906723, -0.017533807083964348, 0.008353527635335922, 0.008611591532826424, -0.012625021860003471, -0.0028274666983634233, -0.013391600921750069, 0.002532627899199724, -0.009786547161638737, -0.011362205259501934, 0.0038659507408738136, 0.01361747458577156, 0.04910556226968765, 0.04550935700535774, 0.00252185994759202, 0.009419746696949005, -0.0032681403681635857, -0.016780054196715355, -0.005788412876427174, 0.01784726232290268, 0.0006986020598560572, -0.018809814006090164, 0.007744148373603821, 0.0019373376853764057, 0.04028710722923279, -0.010596837848424911, 0.012301542796194553, 0.005952765699476004, 0.0006833377992734313, -0.0058807493187487125, -0.027077792212367058, -0.002825652016326785, 0.005848749075084925, -0.03196542710065842, -0.016994653269648552, 0.01641707308590412, -0.04372771829366684, -0.0007180226966738701, -0.00823967158794403, -0.017157062888145447, -0.04169144481420517, -0.02044043131172657, 0.026195969432592392, 0.005430534482002258, 0.011007376946508884, -0.030788559466600418, -0.00946392398327589, 0.01909817010164261, -0.02234315499663353, -0.013889100402593613, 0.006268413737416267, 0.032953351736068726, 0.06128707528114319, 0.01886727102100849, 0.03504634276032448, -0.031481485813856125, 0.04148496687412262, -0.00026291143149137497, -0.012861648574471474, 0.009129825979471207, 0.027270957827568054, 0.023531824350357056, 0.005819966085255146, -0.005319592542946339, -0.019474949687719345, -0.02174408733844757, 0.0023776732850819826, 0.010233310982584953, -0.007109344005584717, -0.0012984848581254482, 0.011205961927771568, -0.007404050789773464, 0.0028197485953569412, 0.035361625254154205, 0.030222807079553604, 0.013234024867415428, -0.04317717254161835, 0.01021520234644413, 0.00107489712536335, -0.00821684580296278, -0.012833116576075554, 0.008444475941359997, -0.013132646679878235, -0.009341148659586906, -0.018509551882743835, -0.012923762202262878, 0.01109025813639164, 0.0321962833404541, 0.012666292488574982, -0.004090568516403437, 0.0053428104147315025, 0.00865181814879179, 0.010003254748880863, 0.025040455162525177, -0.013870625756680965, 0.02168312668800354, 0.002219468355178833, -0.01297940593212843, 0.007938031107187271, 0.012569442391395569, -0.050950974225997925, 0.017803385853767395, 0.0031379684805870056, -0.04617470130324364, -0.01678312197327614, 0.020056962966918945, 0.006628559902310371, -0.025995519012212753, 0.03459791839122772, -0.0045720357447862625, 0.019305819645524025, -0.04565209895372391, 0.017661286517977715, 0.01982351392507553, -0.011812640354037285, -0.020058292895555496, 0.03078516572713852, 0.004241280257701874, -0.025606699287891388, -0.011753879487514496, -0.00028991844737902284, 0.014778128825128078, 0.006528341677039862, -0.0029931850731372833, 0.014200389385223389, 0.04220475256443024, 0.007958236150443554, 0.009997203014791012, 0.007507743779569864, 0.011904241517186165, 0.032481104135513306, -0.009768347255885601, -0.037261009216308594, 0.019563894718885422, -0.005949939601123333, -0.026651401072740555, -0.024462293833494186, -0.006942921318113804, 0.01613042876124382, 0.024551572278141975, 0.01683502458035946, 0.016809601336717606, -0.01931620016694069, 0.005891235079616308, 0.001977815292775631, 0.017121639102697372, -0.005703618284314871, 0.016086837276816368, 0.0188564732670784, -0.01410510204732418, -0.011491193436086178, 0.023365916684269905, -0.013660226948559284, -0.017583943903446198, -0.021651718765497208, 0.013952324166893959, -0.014756656251847744, 0.023183166980743408, 0.0255538672208786, -0.05102211982011795, 0.02751091495156288, -0.012580513954162598, -0.010285384953022003, 0.0021627964451909065, -0.00688193878158927, -0.0002485362347215414, -0.0004881615750491619, 0.005196854472160339, -0.017154492437839508, -0.016921591013669968, -0.005530975759029388, -0.005208508111536503, -0.02410060167312622, -0.0096840625628829, -0.019635368138551712, -0.030877795070409775, 0.008770122192800045, -0.009453481063246727, -0.01082391757518053, -0.007614988833665848 ]
[ 0.30348196625709534, -0.08111442625522614, 0.6345973610877991, -0.29214030504226685, -0.030199933797121048, -0.32333052158355713, -0.12361609190702438, -0.7343405485153198, -1.05623197555542, 0.06527317315340042, 0.2764166593551636, 0.1429186314344406, -0.6249796152114868, 0.30977708101272583, 0.1448894739151001, 0.8500783443450928, 0.5456201434135437, 0.310383141040802, 0.11338222771883011, -0.29297369718551636, -0.3101045489311218, 0.05252327397465706, 0.8333938717842102, -0.033154524862766266, 0.3846718966960907, -0.2675129473209381, 0.4244518578052521, -0.06088796257972717, 0.01231355220079422, -0.1856522411108017, -0.5000738501548767, 0.5285714268684387, -0.005051718093454838, 0.32067933678627014, 0.14066502451896667, -0.3001951575279236, -0.15010833740234375, -0.08096079528331757, -0.04538307338953018, -0.450134813785553, -0.21065834164619446, 0.11054155230522156, -0.7157583832740784, 0.5452910661697388, -0.01624905690550804, -0.6428322196006775, -1.0393614768981934, 0.3437584936618805, -0.28500688076019287, -0.35172683000564575, 0.16103500127792358, -0.0497809574007988, 0.47549358010292053, 0.005122192669659853, 0.4022412598133087, 0.11966854333877563, -0.9671417474746704, 0.0037752168718725443, 0.39256155490875244, -0.5940924882888794, 0.03643512353301048, 0.3485918641090393, -0.3101898729801178, -0.058672383427619934, 0.4239964485168457, 0.7021236419677734, -0.059669893234968185, 0.14783133566379547, -0.08521728962659836, -0.4479480981826782, -0.058575619012117386, -0.3694186210632324, -0.1047477051615715, -0.09640348702669144, -0.02624884992837906, 0.17052897810935974, -0.17731648683547974, -0.1696457862854004, 0.027904363349080086, -0.03486356884241104, 0.07111494243144989, 0.5047482252120972, 0.48992428183555603, 0.17131288349628448, 0.4494973421096802, 0.03756269812583923, -0.6501166820526123, 0.987855851650238, 0.051825858652591705, -0.420884907245636, -0.16773422062397003, 0.24909883737564087, 0.3020801246166229, 0.10345906019210815, 0.2722994089126587, -0.05414700508117676, -0.0910446047782898, 0.07070402801036835, 0.04666450619697571, 0.5249506235122681, -0.2025478184223175, -0.30831852555274963, -0.29820576310157776, -0.03652258217334747, 0.3163464665412903, -0.06245206668972969, -0.28986498713493347, 0.02797861211001873, -0.4931424558162689, 0.10274121910333633, -0.3144323527812958, -0.09061246365308762, -0.4343641996383667, -0.727949321269989, 0.2407861053943634, 0.3495749831199646, 0.5944718718528748, 0.028840189799666405, -0.12852974236011505, 0.21735422313213348, -0.25914284586906433, 1.2515769004821777, 0.0014084494905546308, 0.5014788508415222, -0.08278877288103104, -0.4402967393398285, 0.398946613073349, 0.29518383741378784, -0.838840126991272, 0.807022750377655, 0.07447382062673569, 0.9807657599449158, -0.31248077750205994, 0.2623043656349182, 0.17858640849590302, -0.9940397143363953, -0.08825099468231201, 0.5287050604820251, 0.5612699389457703, 0.047717753797769547, -0.38472455739974976, 0.012141709215939045, -0.06288310885429382, -0.032876525074243546, -0.2616145610809326, -0.4259990155696869, -0.04796704277396202, -0.14391349256038666, -0.6431906819343567, -0.17312569916248322, 0.495672345161438, -0.24785301089286804, -0.4227517545223236, 0.42376410961151123, -0.08421619236469269, 0.2321048378944397, 0.11377155780792236, -0.22367282211780548, -0.6021420359611511, -0.06780433654785156, -0.3882215619087219, -0.44012194871902466, -0.22360987961292267, -0.28471097350120544, 0.26620063185691833, -0.20058120787143707, 0.5292662382125854, 0.3051321804523468, 0.5151920318603516, -0.03362347558140755, -0.30203384160995483, -0.1323471963405609, -0.3544001579284668, -0.52872633934021, 0.28012439608573914, -0.243341863155365, -0.2488197237253189, -0.08186712861061096, -0.3929080367088318, 0.09596623480319977, -0.660228431224823, 0.2668173611164093, -0.35542207956314087, -0.5754146575927734, 0.34321001172065735, 0.24717502295970917, 0.7215737104415894, 0.13344204425811768, -0.11595247685909271, -0.3372687101364136, 0.42531654238700867, 0.5117861032485962, 0.3518125116825104, -0.4952583611011505, 1.523086428642273, 0.1741705983877182, -0.5323140025138855, 0.6700698733329773, 0.18395870923995972, -0.070126973092556, -0.6638197898864746, 0.18623895943164825, 0.37043097615242004, -0.7545732855796814, -0.6783199906349182, -0.3339104652404785, 0.3164115846157074, 0.1980445683002472, 0.5752608776092529, 0.2423303872346878, 0.6955508589744568, -0.3144534230232239, -0.03526277840137482, -0.5305500030517578, 0.2945650517940521, -0.34255918860435486, -0.027550434693694115, 0.27940690517425537, -0.10762424767017365, 0.3056623637676239, 0.25551027059555054, -0.5865347981452942, 0.49088412523269653, 1.0956395864486694, -0.19125795364379883, 0.7315806746482849, 0.4481103718280792, -0.3027097284793854, 0.5883378386497498, -0.10058589279651642, 0.3521791100502014, -0.45895564556121826, 0.39394089579582214, -0.5100105404853821, -0.12045571953058243, 0.1533757597208023, 0.21812160313129425, -0.3151034712791443, -0.5620335340499878, -0.017628680914640427, 0.09169072657823563, 0.45545315742492676, -0.7363175749778748, 0.3598228394985199, 0.16111835837364197, -0.23356351256370544, -0.3654760718345642, 0.26745516061782837, -0.6182705163955688, 0.13741198182106018, 0.1348917931318283, 0.6563823223114014, -0.035102590918540955, -0.6061251163482666, 0.17642094194889069, -0.40354645252227783, -0.2855384349822998, -0.46425825357437134, 0.4530869722366333, -0.20004458725452423, -0.4247085452079773, -0.3500995635986328, 0.20447863638401031, 0.35346952080726624, -0.6547037959098816, 0.2653084993362427, -0.277349054813385, -0.13868354260921478, 0.5158326029777527, 0.6300568580627441, 0.6989817023277283, 0.3099856674671173, -0.9275144338607788, -0.014132668264210224, -0.004510999657213688, -0.43313950300216675, 0.07377400249242783, 0.39673012495040894, -0.07890791445970535, -0.40476933121681213, -0.19707152247428894, 0.3487732708454132, 1.2833399772644043, -0.3687676191329956, -0.6873171925544739, -0.2949965000152588, -0.39597004652023315, 0.1049453467130661, -0.10437949001789093, -0.6606867909431458, -0.41048938035964966, 0.06882570683956146, -0.30979111790657043, 0.12059195339679718, -0.13485820591449738, 0.2172745168209076, -0.4444965720176697, 0.32277098298072815, 1.0422141551971436, -0.3918725252151489, -0.25644204020500183, -0.08936558663845062, -0.22757722437381744, -0.18172650039196014, 0.3465304672718048, -0.10026347637176514, -0.343939870595932, 0.0517658069729805, -5.634910583496094, 0.3833658993244171, 0.23769064247608185, 0.005781799089163542, -0.45320650935173035, 0.08964371681213379, 1.0288488864898682, -0.25508788228034973, 0.3745366036891937, 0.11404895782470703, -0.10629638284444809, 0.5001211762428284, -0.19861482083797455, -0.10824228078126907, -0.2051633894443512, 0.2934277355670929, 0.5709351301193237, 0.25507092475891113, 0.33358243107795715, 0.33439186215400696, 0.3005506694316864, -0.17322677373886108, 0.2087116241455078, 0.3859599232673645, 0.2804757356643677, -0.22321875393390656, -0.6054255366325378, -0.021509896963834763, -0.0450141616165638, 0.04428045451641083, -0.2151263952255249, -0.07519468665122986, 0.2572707235813141, -0.2151850312948227, 0.11861290782690048, 0.26600658893585205, 0.278672993183136, -0.21684662997722626, -0.48214083909988403, -0.1211194321513176, 0.5605943202972412, 0.31932905316352844, 0.33695706725120544, 0.4846497178077698, 0.19631032645702362, 0.13289852440357208, 0.006045919843018055, -0.2995774447917938, -0.26660364866256714, 1.2010961771011353, 0.4828457534313202, -0.35787272453308105, 0.4683675467967987, -0.3075965344905853, 0.5463194847106934, 0.22549083828926086, -0.10555446892976761, -0.21265047788619995, -0.5842562913894653, 0.3792027533054352, -0.1605547070503235, -0.0828847661614418, -0.31241849064826965, -0.15313838422298431, -0.2792287766933441, 0.2495967447757721, -1.1054333448410034, -0.5945201516151428, 0.7953578233718872, -0.2796700596809387, -0.6387903690338135, 0.4119150936603546, 0.16715113818645477, -0.5851680636405945, 0.5169411897659302, 0.41333895921707153, -0.26302963495254517, -0.019621437415480614, -0.14531703293323517, 0.36817508935928345, -0.7314049005508423, 0.3461538851261139, 0.2562880516052246, 0.02875368297100067, 0.1459723711013794, 0.08690211176872253, -0.27753424644470215, 0.10487758368253708, -0.7727486491203308, 0.15819449722766876, 0.41355958580970764, -0.1914585828781128, 0.05361379683017731, 0.22589556872844696, -0.12241842597723007, 0.10722772777080536, 0.3231353759765625, 0.4346846044063568, 0.25701403617858887, -0.46778610348701477, 1.1055896282196045, -0.14726901054382324, -0.6068580746650696, -0.7759256362915039, -0.22240516543388367, -0.20745797455310822, -0.645208477973938, 0.1134917363524437, 0.24487578868865967, -0.37929123640060425, 0.281157910823822, 0.38135695457458496, -0.5936728119850159, -0.11178497225046158, 0.7974775433540344, -0.027553264051675797, -0.6254134774208069, -0.2717360854148865, 0.8864094614982605, -0.8358911871910095, 0.24832898378372192, 0.6889345645904541, -0.7863055467605591, 0.3357956111431122, -0.06029796972870827, -0.20069043338298798, 0.13722367584705353, 0.5637894868850708, -0.11437182873487473, 0.17056454718112946, 0.263185054063797, 0.42620158195495605, -0.3937636613845825, -0.09488817304372787, 0.11910689622163773, -0.328328937292099, -0.4101738929748535, 0.04463789984583855, 0.62185138463974, -0.20870165526866913, 0.53132563829422, -0.4965147376060486, -0.01794995367527008, 0.16728393733501434, 0.32998353242874146, 0.12015960365533829, 0.21039995551109314, 0.5498348474502563, -0.32424992322921753, -0.46421217918395996, 0.18999037146568298, -0.37324759364128113, -0.07634889334440231, -0.22398655116558075, 0.002630555536597967, 0.07501150667667389, 0.649221658706665, 0.2190188765525818, 0.7273529171943665, -0.7314980626106262, 0.6461334228515625, 0.270207017660141, -0.6116059422492981, 0.10826705396175385, -0.4439099431037903, -0.1362118422985077, -0.5383316278457642, -0.05604731664061546, -0.029127011075615883, 0.37206435203552246, -0.6207529902458191, -0.49961864948272705, -0.844011664390564, -0.6845192313194275, 0.2029493749141693, -0.16171963512897491, 0.004102271981537342, -0.3313920497894287, -0.6705507636070251, -0.47257915139198303, -0.04547863453626633, -0.6460311412811279, 0.06666962802410126, 0.49414581060409546, 0.4816588759422302, -0.5846354961395264, -0.1370888203382492, 0.13956612348556519, -0.600638210773468, -0.3632374107837677, 0.5174285173416138, 0.16811758279800415, 0.013236796483397484, -0.2946358025074005, -0.08418992906808853, -0.45276153087615967, -0.17172323167324066, 0.7331220507621765, -0.24324791133403778, -0.7630367875099182, 0.05152256414294243, 0.17216037213802338, 0.15568913519382477, 0.3445853888988495, 0.2367875874042511, 0.3929813802242279, -0.13050289452075958, -0.044368863105773926, -0.1053205132484436, -0.403361439704895, 0.2335144728422165, -0.5921953916549683, -0.17307348549365997, 0.38367873430252075, -0.30213651061058044, 0.594254732131958, 0.2287818044424057, -0.19374825060367584, -0.41127997636795044, 0.11500120908021927, 0.4350123703479767, -0.16746701300144196, -0.19956503808498383, -0.1916356086730957, -0.19355228543281555, 1.0812032222747803, 0.20865952968597412, -1.0260779857635498, 0.47187191247940063, 0.41851991415023804, -0.08538872003555298, -0.7318252325057983, -0.301431804895401, -0.21601133048534393, -0.32949426770210266, -0.06288623809814453, -0.7193597555160522, 0.33873045444488525, -0.06649476289749146, 0.6511355042457581, 0.05346151441335678, 0.42726758122444153, -0.8259793519973755, -0.32249483466148376, -0.40824735164642334, 0.6688305735588074, 0.6101138591766357, -0.22426936030387878, -0.4332958161830902, 0.2676757574081421, 0.6330031156539917, -0.09856599569320679, 0.2890491485595703, 0.3147681653499603, 1.1192312240600586, 0.29002460837364197, -0.4086305499076843, -0.2658228278160095, 0.06521410495042801, 0.2777109146118164, -0.045287031680345535, 0.13099482655525208, -0.4326460361480713, -0.34524819254875183, 0.07338880002498627, -0.12633812427520752, -0.3764989376068115, -0.7381389737129211, 0.46529796719551086, 0.04683702439069748, -0.6223061680793762, -0.3535837233066559, 0.8822152614593506, 0.6066529154777527, -0.38079172372817993, 0.4352607727050781, -0.4605279564857483, -0.242829829454422, -0.23833070695400238, 0.03798808157444, -0.5200671553611755, -0.6385705471038818, 0.12869034707546234, -0.5759431719779968, 0.49985888600349426, -0.3017897307872772, -0.13325347006320953, -0.15399488806724548, -0.23536139726638794, -0.11583710461854935, -0.03629383072257042, -0.48864442110061646, -0.3349805772304535, -0.7399205565452576, 0.5008266568183899, 0.5431147217750549, 0.12561076879501343, -0.02232407033443451, -0.3509252369403839, 0.055548787117004395, -0.36800456047058105, 0.2126399278640747, 0.692318320274353, -0.44034266471862793, 0.16976429522037506, 0.009217122569680214, 0.18470145761966705, 0.09265513718128204, -0.17332692444324493, -0.3741164803504944, -0.17938381433486938, 0.030271416530013084, 0.29251837730407715, 0.12238401174545288, -1.132130742073059, 0.09730920195579529, 0.3706814646720886, -0.27061018347740173, 0.45472919940948486, 0.2682562470436096, 0.3678465783596039, 0.4295175075531006, 0.3042971193790436, -0.25961995124816895, -0.21487055718898773, 0.3092765212059021, 0.40576502680778503, 0.34940123558044434, -0.2687765657901764, 0.4047929644584656, 0.6382996439933777, 0.3377683758735657, -0.09157729893922806, 0.6920784115791321, 0.31721529364585876, 0.3007583022117615, -0.008782955817878246, -0.4531768262386322, -0.4644750952720642, 0.3651185929775238, 0.5229272842407227, 0.6106211543083191, -0.5240803956985474, 0.0390302799642086, 0.3699071705341339, -0.05983910337090492, 0.7137200832366943, -0.39147114753723145, -0.019718801602721214, 0.3945344090461731, 0.41803178191185, -0.37839868664741516, -0.2952260375022888, 0.3523474633693695, -0.6869378685951233, -0.36987465620040894, 0.46927809715270996, -0.31152454018592834, -0.39047324657440186, -0.20752251148223877, -0.16516421735286713, 1.0548619031906128, -0.27901697158813477, 0.3698517680168152, -0.2903228998184204, 0.10762391984462738, 0.19194266200065613, 0.4935961067676544, -0.47616368532180786, 0.08492713421583176, 0.33747702836990356, 0.009303774684667587, -0.1795872002840042, 0.2718811333179474, 0.3202172815799713, -0.2982216775417328, 0.03181071579456329, 0.2237461507320404, 0.11119524389505386, 0.21036767959594727, 0.2315535843372345, 0.6957374811172485, -0.23432916402816772, -0.5133311152458191, -0.38677069544792175, -0.17397573590278625, 0.03621997311711311, 0.013011816889047623, -0.22168107330799103, -0.23684090375900269, 0.09398593008518219, -0.4926571846008301, 0.08261784166097641, 0.2997930943965912, -0.08623909205198288, -0.2638412117958069, 0.26985520124435425, 0.5220007300376892, 0.4792669415473938, -0.07640524953603745, -0.15524700284004211, 0.23657268285751343, -0.20479783415794373, 0.3281203806400299, -0.6034857630729675, 0.949022650718689, -0.7253323793411255, 0.03221551701426506, -0.3780110776424408, 0.349208801984787, 0.858217179775238, 0.46608778834342957, -0.22276359796524048, -0.21240226924419403, 0.2647629678249359, 0.1993110626935959, 0.1639680117368698, -0.5401056408882141, -0.5429682731628418, -0.6117290258407593, -0.029048750177025795, -0.5948653221130371, 0.8769207000732422, 0.2738168239593506, 0.01773781329393387, -0.5112821459770203, 0.18741510808467865, 0.29249048233032227, -0.5778211951255798, -0.26429054141044617, 0.019738445058465004, -0.47262540459632874, -0.35652488470077515, 0.6489819884300232, -0.18184007704257965, 0.298478364944458, -0.2536351680755615, -0.06976673752069473, 0.001251082168892026, 0.2547471523284912, 0.7890678644180298, -0.029064420610666275, 0.2475486844778061, -0.3380720317363739, 0.2915263772010803, 0.38510438799858093, -0.330752432346344, -0.07341663539409637, -0.5557171702384949, -0.34567713737487793, 0.12395399063825607, -0.5793472528457642, 0.19128215312957764, 0.19124619662761688, -0.05690592899918556, -0.02134016901254654, -0.3922043442726135, -0.2605253756046295, -0.20234660804271698, -0.28040772676467896 ]
Recent technological improvements in the elastic substrate method make it possible to produce spatially resolved measurements of the tractions exerted by single motile cells. In this study we have applied these developments to produce maps of the tractions exerted by 3T3 fibroblasts during steady locomotion. The resulting images have a spatial resolution of approximately 5 micrometers and a maximum intensity of approximately 10(2) kdyn/cm2 (10(4) pN/micrometers2). We find that the propulsive thrust for fibroblast locomotion, approximately 0.2 dyn, is imparted to the substratum within 15 micrometers of the leading edge. These observations demonstrate that the lamellipodium of the fibroblast is able to generate intense traction stress. The cell body and posterior seem to be mechanically passive structures pulled forward entirely by this action.
[ 0.000040607061237096786, 0.0029803048819303513, -0.0215420164167881, 0.009229772724211216, 0.0006351873744279146, -0.0016121026128530502, 0.010651243850588799, -0.0031018550507724285, -0.008287189528346062, -0.017009465023875237, 0.0004075381439179182, 0.01896059513092041, -0.01374206505715847, 0.01991313137114048, 0.008425978012382984, -0.01113838329911232, -0.033460527658462524, -0.002482258714735508, 0.00564914895221591, 0.006680419202893972, -0.0016676350496709347, -0.02295197732746601, 0.011784392409026623, -0.016285354271531105, -0.029536286368966103, -0.015108009800314903, 0.0022677727974951267, -0.00018435390666127205, -0.0031886210199445486, 0.01498412899672985, 0.0004728339845314622, 0.0006440149154514074, 0.004988167434930801, 0.02370600774884224, -0.00024401373229920864, -0.02406119555234909, -0.008340323343873024, 0.01965327560901642, -0.029439091682434082, -0.004995511844754219, -0.011463762260973454, -0.006352746859192848, 0.012442522682249546, -0.019915077835321426, -0.009829767048358917, -0.0002443436533212662, -0.008878793567419052, 0.003294224850833416, -0.010698097757995129, 0.010650306940078735, -0.007283495739102364, -0.0204574353992939, -0.00645202724263072, 0.0425950363278389, -0.007054092362523079, -0.023372052237391472, 0.020248664543032646, 0.011828264221549034, -0.030804304406046867, -0.012238051742315292, 0.004805666394531727, 0.010985264554619789, -0.009998930618166924, 0.010844558477401733, 0.01952965557575226, -0.06670483946800232, 0.0032428111881017685, 0.018173711374402046, -0.002025122521445155, 0.0024760623928159475, -0.013263403438031673, 0.011448824778199196, 0.02128121256828308, 0.00932010542601347, -0.017165496945381165, -0.023237327113747597, -0.02115616761147976, 0.004986083600670099, -0.002308049937710166, 0.01590018905699253, 0.013596226461231709, -0.022778324782848358, -0.016294969245791435, 0.02357885055243969, -0.014290188439190388, -0.008238005451858044, -0.0027426802553236485, -0.002518727909773588, 0.01419486477971077, -0.0032493234612047672, 0.015913628041744232, 0.01710624061524868, -0.01162783894687891, 0.0010348646901547909, -0.03884369134902954, 0.03564079478383064, -0.004032056778669357, -0.009819958359003067, 0.009143650531768799, -0.0004768776707351208, -0.033498138189315796, 0.005038621835410595, 0.024390242993831635, -0.006824292708188295, -0.021720102056860924, 0.008077532984316349, 0.0029929261654615402, 0.0002979440614581108, 0.015795882791280746, 0.004392328206449747, 0.002106210682541132, -0.007330803666263819, -0.020610295236110687, 0.008860746398568153, 0.013653242960572243, 0.005345516838133335, 0.004443759098649025, -0.001585307065397501, 0.0029584120493382215, 0.0013507885159924626, 0.018505623564124107, 0.004967996384948492, -0.0015484491595998406, 0.0020074481144547462, 0.008746633306145668, -0.01565765030682087, -0.009934169240295887, 0.003736665705218911, 0.012851711362600327, 0.00027972529642283916, -0.008912885561585426, 0.030022628605365753, 0.0018137055449187756, 0.009646275080740452, 0.004639431834220886, 0.004977433476597071, -0.009548764675855637, -0.009282732382416725, 0.0022741826251149178, -0.00848884042352438, 0.0005920699331909418, 0.009950242005288601, -0.0009902904275804758, 0.009723136201500893, -0.004934445954859257, -0.010057111270725727, -0.0042516752146184444, 0.005117451772093773, 0.019560879096388817, -0.020187124609947205, 0.01955784484744072, -0.021129727363586426, -0.011671830900013447, -0.027145560830831528, 0.01635143905878067, -0.008589403703808784, -0.029481088742613792, 0.00008311402052640915, 0.006484538316726685, -0.0005244114436209202, -0.0004947069101035595, -0.023968786001205444, 0.02689828723669052, 0.011426909826695919, 0.007984098047018051, 0.026394687592983246, -0.010880476795136929, -0.015005981549620628, 0.012582704424858093, 0.008447755128145218, -0.0022308938205242157, -0.012070922181010246, -0.019609704613685608, 0.006053942255675793, -0.007332568056881428, 0.011634144932031631, -0.00641403254121542, 0.007631212472915649, -0.002793252468109131, 0.06734073907136917, 0.017158590257167816, 0.02893974632024765, 0.008978347294032574, 0.00746206333860755, 0.00753615889698267, -0.0014092091005295515, -0.020833536982536316, -0.01510382816195488, 0.0087072579190135, 0.019730258733034134, 0.0005006864666938782, 0.013990995474159718, 0.004646293353289366, 0.0015969185624271631, 0.0062675634399056435, 0.0030872258357703686, 0.022666223347187042, 0.0022859759628772736, -0.009575347416102886, -0.032732099294662476, -0.0030860400293022394, -0.01406694296747446, 0.016691163182258606, -0.010800454765558243, 0.008241001516580582, 0.01824534684419632, 0.00811472162604332, -0.016714245080947876, 0.015350324101746082, 0.018756644800305367, 0.02530558966100216, 0.006025495007634163, -0.0037393528036773205, 0.001278495416045189, -0.02411576360464096, -0.012701860629022121, -0.011314252391457558, 0.0035842128563672304, -0.010406534187495708, -0.012110917828977108, 0.0030897364486008883, -0.005675413645803928, 0.030577564612030983, -0.002683082362636924, 0.012415110133588314, 0.011114520952105522, -0.0015254581812769175, 0.012552453204989433, 0.023989282548427582, 0.006791830062866211, 0.013601042330265045, -0.0246991328895092, -0.017977379262447357, 0.0008152948576025665, 0.007676199544221163, 0.0012333070626482368, 0.01760268025100231, -0.020310072228312492, 0.033169135451316833, -0.012489414773881435, 0.0031567157711833715, -0.014071712270379066, 0.016160588711500168, -0.027041327208280563, -0.01101933978497982, 0.016459118574857712, 0.025713246315717697, -0.003910010680556297, 0.01209207158535719, -0.015689348801970482, 0.008101324550807476, 0.018192019313573837, -0.008314496837556362, -0.0029760031029582024, 0.002867182483896613, -0.022700760513544083, -0.010729053989052773, 0.030896179378032684, 0.022596018388867378, -0.01826443150639534, 0.008657178841531277, 0.010243299417197704, -0.01549956202507019, 0.029467890039086342, -0.019110511988401413, 0.020756350830197334, 0.022080721333622932, 0.019300552085042, 0.01927093416452408, -0.00014035915955901146, 0.009549041278660297, -0.016429241746664047, -0.007365094497799873, -0.08024232089519501, -0.018960103392601013, -0.0019751074723899364, -0.006101327948272228, 0.012417944148182869, -0.00042630801908671856, 0.016676686704158783, -0.0006050678784959018, -0.00236605666577816, 0.013002971187233925, 0.004027308896183968, -0.005656341556459665, -0.002259586239233613, 0.0024311691522598267, -0.027560055255889893, -0.0149180106818676, 0.018777118995785713, -0.022778000682592392, 0.017502617090940475, 0.014672896824777126, -0.01641252636909485, -0.036222878843545914, -0.008303377777338028, 0.014959021471440792, -0.015011660754680634, 0.001986174378544092, 0.017777372151613235, -0.010315759107470512, -0.024540012702345848, 0.009675905108451843, -0.002210428472608328, 0.02737518399953842, 0.00734406104311347, -0.017383746802806854, 0.025041259825229645, 0.015710534527897835, 0.001924246083945036, -0.013781174086034298, -0.007385577075183392, 0.03537081927061081, 0.0073895021341741085, 0.0002657766453921795, -0.022990494966506958, 0.012248924002051353, -0.0055514671839773655, 0.010840674862265587, 0.015004895627498627, 0.020032444968819618, 0.024683671072125435, -0.018379859626293182, -0.008511307649314404, 0.005873666610568762, 0.013403398916125298, 0.020154904574155807, -0.027791520580649376, -0.007385314907878637, -0.011219817213714123, -0.000559663400053978, -0.009110468439757824, -0.011258566752076149, -0.0024524324107915163, -0.01631174236536026, -0.022205648943781853, 0.0013946807011961937, -0.010199975222349167, 0.01149936392903328, 0.007401068229228258, -0.03366614133119583, -0.01765425316989422, 0.016628284007310867, 0.01922028884291649, 0.020384471863508224, -0.04230228811502457, -0.011109769344329834, -0.029139423742890358, -0.011237263679504395, -0.01576954312622547, -0.004381383303552866, 0.028591211885213852, 0.00520077720284462, -0.024761712178587914, 0.0202716663479805, -0.015907546505331993, 0.010934403166174889, -0.034662455320358276, -0.010093364864587784, 0.007612967863678932, 0.02018803544342518, 0.013928497210144997, -0.009871813468635082, 0.02166343480348587, 0.022868631407618523, 0.013691138476133347, 0.004213801119476557, 0.013579708524048328, 0.035792652517557144, -0.00949111394584179, 0.008261334151029587, 0.009403742849826813, 0.0120145408436656, -0.01274300366640091, -0.007388504222035408, 0.0017764484509825706, -0.01101774349808693, -0.02607840672135353, 0.0131621602922678, 0.009565122425556183, -0.007971696555614471, 0.009376300498843193, -0.006372834090143442, -0.015235256403684616, -0.017082449048757553, -0.008973320946097374, 0.0032015666365623474, 0.016899412497878075, 0.03484257683157921, 0.004238612949848175, 0.007304753176867962, 0.07178671658039093, -0.005787757225334644, 0.0072958520613610744, -0.01590767502784729, 0.013086598366498947, -0.03431612253189087, 0.020450852811336517, 0.012449407950043678, 0.008125752210617065, -0.027768054977059364, 0.011681599542498589, -0.018886322155594826, 0.036910783499479294, 0.031244903802871704, -0.0022083583753556013, -0.007695381063967943, -0.007487349212169647, 0.01939474791288376, -0.010379096493124962, -0.005741872359067202, -0.028809309005737305, 0.0008570667123422027, -0.011795985512435436, -0.019522804766893387, 0.017442191019654274, -0.028192151337862015, 0.029362065717577934, -0.01369020901620388, -0.012276554480195045, 0.013852853327989578, -0.005525143351405859, -0.05545078217983246, -0.009571773931384087, -0.029062533751130104, 0.030481982976198196, 0.025279048830270767, 0.00017981184646487236, 0.002310783602297306, -0.007372257299721241, -0.0007715590763837099, 0.0004913019947707653, -0.013894204050302505, 0.027583003044128418, 0.014226564206182957, 0.028031878173351288, -0.03083799034357071, 0.008810197934508324, -0.006670891772955656, -0.018742986023426056, -0.002997877076268196, -0.01565384492278099, 0.012303491123020649, 0.016890734434127808, -0.009907632134854794, 0.007991304621100426, -0.022877413779497147, 0.002137200441211462, -0.0034129470586776733, -0.0007693353109061718, -0.005840626545250416, -0.006938144098967314, 0.00048657949082553387, -0.008265059441328049, -0.02503097429871559, 0.012640979140996933, -0.015544125810265541, -0.012957781553268433, -0.0026795361191034317, 0.012698082253336906, 0.002594458870589733, 0.013876212760806084, -0.009288724511861801, 0.001381400041282177, 0.002463290933519602, -0.006562212482094765, -0.0031093177385628223, -0.001564714009873569, -0.012521941214799881, 0.004691486246883869, -0.0010889023542404175, -0.030222713947296143, 0.011048434302210808, -0.02702414244413376, -0.031354792416095734, -0.018459275364875793, -0.029650863260030746, -0.0007068742997944355, -0.073855459690094, 0.012807294726371765, 0.010605914518237114, -0.007740338798612356, 0.004887754563242197, 0.02566056326031685, -0.008748405613005161, 0.007084812503308058, 0.028170187026262283, -0.008159955963492393, -0.014334628358483315, -0.015204990282654762, 0.006564069539308548, -0.00799563992768526, 0.012893307954072952, -0.01595282182097435, -0.03768150508403778, 0.008587107062339783, -0.016767309978604317, 0.008034035563468933, 0.009580137208104134, 0.046460799872875214, -0.002961731981486082, -0.011026615276932716, -0.00875273160636425, -0.08044597506523132, 0.010582026094198227, 0.009150683879852295, 0.00930013321340084, -0.006908410228788853, -0.035474613308906555, 0.002419046126306057, -0.018427185714244843, 0.007246759720146656, -0.013635583221912384, -0.0067954519763588905, -0.0063799223862588406, 0.0134701207280159, -0.013282949104905128, 0.00800144113600254, -0.0049631935544312, 0.0045027476735413074, -0.002573424018919468, 0.002285593654960394, 0.02316216006875038, 0.012845583260059357, 0.01081682275980711, -0.011106302961707115, 0.0029297953005880117, -0.00273857987485826, -0.004533631727099419, -0.01067708432674408, 0.011563558131456375, 0.0279141366481781, 0.004845328629016876, -0.011074996553361416, 0.014386342838406563, -0.014161302708089352, 0.0009176288731396198, -0.0026141121052205563, -0.029765857383608818, -0.002418552991002798, -0.0016728580230847, -0.002188489306718111, -0.00022750115022063255, -0.007567341439425945, -0.015669627115130424, 0.010976618155837059, 0.001062340335920453, 0.0012138811871409416, -0.03213813155889511, 0.006834292784333229, -0.01365636195987463, 0.007788661867380142, 0.0063657984137535095, 0.016013160347938538, -0.00045346375554800034, 0.010937342420220375, 0.002168711507692933, -0.017520714551210403, -0.01695212349295616, -0.006343252956867218, 0.016784606501460075, 0.016513414680957794, 0.02015804685652256, 0.004251433536410332, 0.02105521596968174, -0.015192207880318165, 0.07248905301094055, -0.004461426287889481, -0.002677647629752755, -0.0004311511293053627, -0.003581900615245104, 0.0076511516235768795, -0.02396681159734726, -0.013738083653151989, -0.0032304669730365276, -0.005549021065235138, 0.02131679467856884, -0.0013623767299577594, -0.02129685878753662, 0.007702022325247526, 0.004875535611063242, 0.01585402898490429, -0.00031656527426093817, 0.02320704609155655, -0.000001671724021434784, -0.0110110342502594, 0.033745333552360535, 0.0097475191578269, 0.0024760467931628227, 0.004963013343513012, -0.017310433089733124, -0.0075750453397631645, -0.009967255406081676, 0.020826730877161026, 0.00820587482303381, -0.026049982756376266, -0.016071481630206108, 0.029703009873628616, 0.005271297879517078, -0.006869637873023748, 0.034582264721393585, 0.013187884353101254, -0.018605580553412437, 0.013563214801251888, -0.018587036058306694, -0.01667815074324608, -0.032907575368881226, 0.02884635701775551, -0.0056324126198887825, 0.009411280043423176, -0.030485551804304123, -0.02485441043972969, -0.003984212875366211, -0.0348304845392704, -0.005320848897099495, 0.012382078915834427, -0.028463244438171387, 0.00005937874084338546, 0.025223614647984505, -0.004212879575788975, 0.0011797994375228882, 0.023098615929484367, -0.008251178078353405, 0.025320783257484436, 0.0023841597139835358, 0.007590827532112598, -0.017934855073690414, -0.0015158506575971842, 0.0070143453776836395, -0.00798649713397026, 0.028935551643371582, 0.009659999050199986, 0.007283777464181185, -0.016304170712828636, -0.02119104564189911, 0.013552555814385414, -0.001899129361845553, 0.023511644452810287, 0.01010989397764206, 0.008741434663534164, 0.006059350445866585, 0.0012774341739714146, 0.008798938244581223, 0.01119152083992958, 0.012451748363673687, 0.00850200466811657, -0.007487241644412279, 0.01688382402062416, 0.004139259457588196, 0.029193608090281487, -0.01587458699941635, -0.0037359707057476044, 0.0166420117020607, 0.030173735693097115, -0.0018123968038707972, 0.014318034052848816, 0.016477283090353012, -0.0005489697214215994, 0.0008953091455623507, 0.009205903857946396, -0.0011880393140017986, 0.03282538801431656, 0.016207750886678696, 0.002187025733292103, 0.00954193901270628, -0.01491622906178236, -0.011107908561825752, 0.0040160370990633965, 0.0032038670033216476, -0.03098541498184204, -0.020074591040611267, -0.009522034786641598, -0.00844133272767067, 0.009234372526407242, -0.0075908382423222065, -0.01100164745002985, -0.029210995882749557, -0.012933576479554176, -0.022014465183019638, 0.0003449989017099142, 0.0010929233394563198, -0.016652747988700867, -0.012015032581984997, -0.0018060271395370364, -0.0023043067194521427, -0.006597443483769894, 0.045781977474689484, 0.024677377194166183, -0.016444213688373566, 0.002235183957964182, -0.010095018893480301, -0.007829831913113594, -0.010836364701390266, 0.01824711263179779, -0.01374097540974617, 0.010269653983414173, 0.018005400896072388, 0.02799937129020691, 0.014909747056663036, -0.02371799945831299, -0.011713411659002304, -0.007006615865975618, -0.009798438288271427, -0.008776862174272537, 0.0077611771412193775, -0.012438350357115269, 0.030287928879261017, -0.00807278510183096, 0.0007942367810755968, 0.009430445730686188, 0.006927661597728729, 0.006134334020316601, 0.020709194242954254, 0.023255201056599617, 0.01497567631304264, -0.0009386730380356312, -0.00543913384899497, -0.0006215666071511805, 0.009904909878969193, -0.005755915772169828, -0.0047888318076729774, 0.006244418676942587, 0.003079631831496954, 0.012516561895608902, -0.0015697162598371506, -0.021050453186035156, 0.00428320188075304, 0.03226533532142639, 0.008705372922122478, -0.014489087276160717, 0.027265630662441254, 0.01841135323047638, 0.04028601199388504, 0.0018415567465126514, -0.012273694388568401, -0.0011908661108464003, -0.028529107570648193, -0.004427646286785603, -0.032494187355041504, 0.007346141617745161, -0.007662884891033173, -0.009156694635748863, -0.0048713781870901585, 0.005375873297452927, 0.00023390084970742464, -0.0024000322446227074, 0.009225244633853436, 0.006785629317164421, 0.0035925935953855515, -0.01337970606982708, -0.007642513141036034, 0.0034064503852277994, -0.0027338385116308928, -0.00044208671897649765, 0.03082011081278324, 0.029912564903497696, -0.016360623762011528, -0.013522526249289513, -0.004024699330329895, 0.004776382818818092, 0.01816485822200775, 0.029966212809085846, 0.02913399040699005, 0.00499252462759614, -0.0021313601173460484, -0.0014879617374390364, -0.013804706744849682, -0.005159182008355856 ]
[ -0.11011650413274765, -0.5167919397354126, 0.3613741993904114, 0.1665603220462799, -0.25056982040405273, 0.4109915494918823, 0.07960405200719833, -0.4727361798286438, -0.5085062980651855, -0.4423905909061432, 0.18221555650234222, 0.6845038533210754, -0.10754336416721344, 0.025778349488973618, 0.019082851707935333, 1.2183820009231567, 0.1675611138343811, 0.0879373550415039, -0.2213490754365921, -0.5469127893447876, -0.22524455189704895, -0.3603231608867645, 1.1217148303985596, 0.1564662605524063, 0.03490592911839485, -0.25986289978027344, 0.4321178197860718, 0.5995810627937317, -0.0008042037952691317, 0.04269895702600479, -0.4306217432022095, 0.39781931042671204, -0.3824314475059509, -0.14649301767349243, 0.48543480038642883, 0.048483431339263916, -0.06397330015897751, -0.06963030993938446, 0.07694823294878006, -0.4457226097583771, 0.1794322431087494, 0.044223010540008545, -0.3765313923358917, 0.5290005207061768, -0.19808532297611237, -0.23713675141334534, -0.9638531804084778, 0.1257503628730774, -0.37721556425094604, 0.31600141525268555, -0.059588029980659485, 0.23505893349647522, 0.2443837821483612, 0.11300498992204666, -0.1353616863489151, 0.19273965060710907, -0.7747666239738464, -0.20877493917942047, 0.5302684903144836, -0.4406779706478119, -0.023062746971845627, -0.15832088887691498, -0.17519894242286682, 0.16929291188716888, -0.2430739402770996, 0.2962248623371124, 0.27660369873046875, -0.09452031552791595, -0.4427071213722229, 0.10092823952436447, 0.6969649195671082, 0.15349332988262177, -0.08699239790439606, 0.4683346748352051, -0.10001980513334274, -0.22996598482131958, -0.16395223140716553, -0.20127348601818085, 0.41055262088775635, 0.3019137382507324, 0.216201052069664, 0.09005938470363617, 0.8068361878395081, 0.031877949833869934, 0.360365629196167, 0.7931646704673767, -0.14646902680397034, 0.8837597370147705, -0.6142393350601196, -0.19656182825565338, -0.28733813762664795, -0.3291144073009491, 0.14015920460224152, 0.6480416655540466, 0.44001534581184387, 0.33242782950401306, 0.054633788764476776, -0.26890861988067627, 0.01892094686627388, 0.29999101161956787, 0.05440204218029976, -0.059082675725221634, -0.3442785441875458, -0.2036549299955368, -0.26407113671302795, -0.4100055396556854, -0.5368258357048035, -0.10061077773571014, -0.3644276559352875, 0.07974737137556076, -0.8970766663551331, 0.038761306554079056, -0.2227785587310791, -0.7073448896408081, 0.13290365040302277, -0.09039787948131561, 0.02860817313194275, -0.1890861690044403, -0.005606107413768768, 0.8229575753211975, -0.39270859956741333, 0.8187147378921509, 0.05442054942250252, 0.28166553378105164, -0.2012893557548523, 0.033457621932029724, 0.10978294909000397, 0.4239092171192169, -0.3631475269794464, 0.4373858571052551, 0.5131097435951233, 0.5909244418144226, -0.1896991729736328, 0.08463243395090103, -0.09937102347612381, -0.8175632953643799, -0.22668614983558655, 0.1955985277891159, 0.09096191078424454, 0.16428200900554657, -0.3890989124774933, -0.81711745262146, -0.3356417119503021, -0.20570336282253265, 0.43235403299331665, -0.8119491934776306, -0.20269855856895447, 0.264847993850708, -0.2650703489780426, 0.01104627177119255, -0.47400012612342834, 0.20370730757713318, -0.6137387156486511, -0.014144480228424072, -0.2575411796569824, 0.018012532964348793, -0.1398281455039978, -0.09973043203353882, -0.1428588479757309, 0.2532908320426941, -0.17364323139190674, -0.027097979560494423, -0.291383296251297, -0.003931012004613876, 0.2700035274028778, -0.49843212962150574, 0.7580897808074951, 0.3154241740703583, 0.2812948524951935, 0.20133401453495026, -0.18185164034366608, -0.19020996987819672, -0.2183292955160141, -0.1444503515958786, -0.542626678943634, -0.09831952303647995, 0.18352945148944855, 0.21165959537029266, 0.21109329164028168, -0.17278511822223663, -0.8295953273773193, -0.06918221712112427, 0.2303624451160431, -0.1688934713602066, 0.2783242464065552, -0.04817523807287216, 0.8070183992385864, -0.1377614289522171, 0.20562361180782318, -0.2054429054260254, 0.2023215889930725, -0.10576093941926956, 0.6655557155609131, -0.8291828036308289, 1.6259477138519287, -0.11295651644468307, -0.24647490680217743, 0.3448941707611084, 0.03501822054386139, 0.1782333254814148, 0.09473675489425659, 0.006925457622855902, 0.34563374519348145, -0.3150116801261902, -0.32137826085090637, -0.02080603502690792, 0.2535024583339691, -0.18523652851581573, -0.1575375497341156, -0.33051666617393494, 0.35250964760780334, -0.3560301959514618, 0.01115820836275816, -0.47196999192237854, 0.04686586931347847, -0.7375448346138, 0.14395371079444885, 0.2407960593700409, -0.06886959075927734, 0.02227400429546833, 1.067906141281128, -0.3291029930114746, 0.016572412103414536, 0.5814785361289978, -0.1663437932729721, 0.6090612411499023, 0.45338207483291626, 0.25514620542526245, 0.6573443412780762, -0.2625715434551239, -0.5553409457206726, -0.16845640540122986, -0.052644163370132446, -0.3697219491004944, -0.19829228520393372, 0.337527871131897, 0.12501104176044464, -0.27908697724342346, 0.28104639053344727, 0.052868183702230453, 0.019116980955004692, 0.9152929782867432, -0.6718255281448364, 0.42854955792427063, -0.12508291006088257, -0.386321097612381, 0.20923329889774323, 0.3892838656902313, -0.7068405747413635, -0.17517980933189392, -0.13166706264019012, 0.03494047746062279, -0.10145837068557739, -0.17809942364692688, -0.03479794040322304, 0.21096205711364746, -0.07791513949632645, -0.5361669659614563, 0.04663938283920288, -0.2894376218318939, -0.21047967672348022, -0.32603561878204346, 0.06521568447351456, -0.020416628569364548, -0.14375810325145721, -0.5258645415306091, -0.7699187994003296, -0.3356165885925293, 0.9198333024978638, 0.5522475242614746, 0.8325054049491882, 0.2485644519329071, -0.22040419280529022, -0.22561118006706238, 0.03479403257369995, -0.46345266699790955, 0.33156490325927734, 0.2587157189846039, -0.6996338963508606, -0.504245400428772, 0.1950313299894333, 0.8583838939666748, 1.2317428588867188, 0.19388845562934875, -0.3234545886516571, -0.2689189314842224, 0.18943513929843903, -0.06747358292341232, -0.3275551199913025, -0.6387112736701965, -0.3134987950325012, -0.11971259117126465, -0.20586208999156952, -0.44622620940208435, -0.25768283009529114, 0.729495644569397, -0.11173581331968307, -0.11500918120145798, 0.31789758801460266, -0.17136487364768982, -0.5584051609039307, -0.2474733144044876, -0.2858210504055023, -0.20197993516921997, -0.2844495475292206, -0.09408526122570038, -0.5358151793479919, 0.29839059710502625, -5.945113658905029, 0.17635715007781982, -0.70062255859375, 0.1515163630247116, 0.19498567283153534, 0.169886976480484, 0.6324641108512878, -0.1529635637998581, 0.148021399974823, -0.2594156861305237, -0.5340288877487183, 0.5253229141235352, -0.1545764058828354, 0.04710182175040245, 0.13229624927043915, 0.4071533679962158, 0.4789803922176361, -0.023870820179581642, 0.4946088194847107, 0.08781382441520691, 0.25248411297798157, -0.5112213492393494, -0.2150631695985794, 0.1938829869031906, 0.5537034869194031, 0.35961028933525085, -0.9187409281730652, -0.12094181776046753, -0.10152258723974228, -0.31480467319488525, -0.41392356157302856, -0.7453131675720215, -0.3542521595954895, -0.4219786822795868, 0.9116355180740356, 0.2558012306690216, 0.1262483447790146, 0.008964261040091515, 0.40406009554862976, -0.5629351139068604, 0.09948873519897461, 0.3909776210784912, -0.32655808329582214, -0.22110402584075928, 0.10618273913860321, -0.2187667042016983, -0.25863999128341675, 0.4905417263507843, -0.14177551865577698, 0.75166255235672, -0.12459403276443481, -0.27042388916015625, 0.3627108931541443, -0.013505193404853344, 0.24905551970005035, -0.28674355149269104, 0.24230900406837463, 0.3668435513973236, -0.1600779891014099, 0.38311898708343506, -0.3571683168411255, -0.5265786051750183, -0.1274864226579666, -0.5287302136421204, -0.17506104707717896, 0.2732015550136566, -0.6898759007453918, -0.18866746127605438, 0.37318700551986694, -0.21488970518112183, -0.3059080243110657, 0.015815161168575287, 0.2649579644203186, -0.5257422924041748, 0.7440599799156189, -0.22272895276546478, 0.3047311305999756, -0.024753373116254807, -0.37969836592674255, 0.09066149592399597, -0.21909204125404358, -0.6631441116333008, 0.057705581188201904, -0.06184806302189827, -0.07971514016389847, -0.6078444123268127, -0.09443014115095139, -0.7191487550735474, 0.13666020333766937, 0.044678568840026855, 0.28652089834213257, -0.43480369448661804, 0.12511296570301056, 0.3763037323951721, -0.0001227120665134862, -0.2596494257450104, 0.5404396057128906, -0.118019700050354, 0.2139645516872406, -0.13466636836528778, 0.6636978983879089, 0.32943055033683777, -0.0004432729328982532, -0.7647926807403564, 0.209451362490654, -0.01064579002559185, -0.19950614869594574, 0.2248401790857315, 0.31039008498191833, -0.10468623787164688, 0.3126848042011261, -0.27896037697792053, -0.42584851384162903, -0.07063182443380356, 0.6164792776107788, -0.2064351886510849, -0.4745289981365204, 0.244950070977211, 0.34734615683555603, -0.17229580879211426, 0.07874448597431183, -0.1626422256231308, -0.16366328299045563, 0.1556731015443802, 0.08353549242019653, 0.4710703194141388, 0.35542935132980347, 0.6994226574897766, -0.6082125902175903, -0.2878429591655731, 0.3973870277404785, 0.5843587517738342, -0.5231053829193115, 0.2662881910800934, -0.2743681073188782, -0.5087835788726807, -0.022889450192451477, -0.20120485126972198, 0.29757291078567505, -0.5109299421310425, 0.2669072151184082, 0.07847747206687927, -0.21592749655246735, -0.2989668846130371, 0.057703908532857895, 0.02312030829489231, 0.18222098052501678, -0.23784580826759338, -0.44801947474479675, -0.04126628488302231, 0.6296120882034302, -0.20629170536994934, -0.0723482295870781, -0.298443078994751, 0.22664284706115723, 0.23416204750537872, 0.32830172777175903, -0.14975062012672424, 0.3211086392402649, -0.5564834475517273, 0.35673558712005615, 0.45616522431373596, -1.143680453300476, 0.3133293092250824, -0.26660001277923584, -0.2649996280670166, -0.3846781253814697, -0.1230502650141716, 0.29019486904144287, -0.07418035715818405, -0.17160524427890778, -0.7447913289070129, -0.3112049698829651, -0.47926923632621765, 0.004812976811081171, -0.3125269412994385, -0.31126150488853455, -0.03257342800498009, 0.23486162722110748, -0.16227580606937408, 0.2602289617061615, -0.24389728903770447, 0.01957724615931511, 0.3710789084434509, 0.7964276075363159, 0.07457475364208221, -0.2667236626148224, -0.01166668813675642, -0.14030946791172028, -0.12044220417737961, 0.7639966011047363, 0.4930773377418518, 0.06278114020824432, -0.2052156776189804, 0.2521679401397705, -0.1327752321958542, 0.6084222793579102, 0.8449345827102661, -0.2290310114622116, -0.3533162474632263, -0.298484206199646, 0.5795524716377258, -0.31224358081817627, 0.5751907825469971, 0.159332275390625, 0.24663136899471283, 0.07605176419019699, 0.44884350895881653, -0.22828884422779083, -0.3233940005302429, -0.35874050855636597, -0.40292981266975403, -0.01982884109020233, 0.05891893804073334, -0.2836591303348541, 0.370842844247818, 0.35687899589538574, -0.4991966784000397, -0.5716304183006287, 0.2718753516674042, -0.012798881158232689, -0.4153580963611603, -0.04525720328092575, -0.10093739628791809, -0.2757152020931244, -0.14342330396175385, 0.30232125520706177, -0.4417794942855835, -0.28969255089759827, 0.0919276550412178, 0.14595967531204224, -0.24397899210453033, 0.12687423825263977, 0.17761491239070892, -0.4684620201587677, 0.31852906942367554, -0.8043447136878967, 0.2011609524488449, -0.3525477647781372, -0.09439150243997574, 0.2806837260723114, 0.7025877833366394, -0.3583778440952301, 0.008393669500946999, 0.015099821612238884, 0.3416993021965027, 0.0937812402844429, -0.8340560793876648, -0.5281347632408142, -0.08724372088909149, 0.4687112271785736, -0.13059687614440918, -0.25752097368240356, 0.2555420398712158, 1.1259387731552124, 0.010823400691151619, -0.050202373415231705, -0.7232279181480408, 0.2989310324192047, 0.43139082193374634, -0.007260099984705448, -0.28535428643226624, -0.15219490230083466, -0.10358326137065887, -0.1257690042257309, 0.14086970686912537, -0.22265712916851044, -0.808130145072937, 0.6405109763145447, -0.1630321443080902, -0.08414126932621002, 0.22180955111980438, 0.060210246592760086, 0.2588759958744049, -0.22400739789009094, 0.032693248242139816, 0.10268384218215942, 0.20124298334121704, -0.14830590784549713, 0.05457112193107605, -0.188296377658844, -0.08311107009649277, 0.220379039645195, -0.18924301862716675, 0.27248963713645935, 0.019278669729828835, 0.4128420948982239, 0.08986230194568634, 0.014757317490875721, -0.17037421464920044, -0.008991309441626072, -0.2161988615989685, -0.6383383870124817, -0.6895250678062439, 0.12565846741199493, 0.5978211164474487, 0.403359979391098, 0.14840444922447205, -0.06358776986598969, -0.2107831984758377, -0.49415692687034607, 0.9841051697731018, 0.47354361414909363, -0.5341970920562744, -0.06038712337613106, -0.10022029280662537, 0.5765660405158997, 0.1437387466430664, -0.2592979371547699, -0.05178209766745567, 0.2881344258785248, 0.2975879907608032, -0.36416923999786377, 0.8936070799827576, -0.04515058547258377, -0.207695871591568, 0.28376537561416626, 0.22612664103507996, 0.2841253876686096, 0.4464765191078186, -0.057453934103250504, 0.7343984246253967, 0.5050901174545288, -0.4763578176498413, -0.3707692325115204, 0.31903350353240967, -0.18178610503673553, 0.300091415643692, -0.15986765921115875, 0.2788309156894684, 0.6690378189086914, 0.3118723928928375, -0.5510926246643066, 0.6449118852615356, 0.5035843849182129, 0.22571194171905518, 0.26592588424682617, 0.22686199843883514, -0.11225082725286484, 0.684937596321106, 0.32172831892967224, 0.5899911522865295, -0.15048463642597198, 0.15872633457183838, 0.13254016637802124, 0.29646825790405273, -0.2441299557685852, -0.11159978806972504, -0.3122738003730774, 0.11192096024751663, 0.4278501570224762, 0.033685069531202316, 0.07452934980392456, -0.08713353425264359, -0.5078000426292419, -0.19475963711738586, 0.6621720194816589, -0.39554810523986816, -0.5231823921203613, 0.4953010678291321, 0.034878961741924286, 0.7556118965148926, -0.16668009757995605, 0.30419665575027466, -0.44630494713783264, -0.17123009264469147, 0.5421462059020996, 0.22275316715240479, -0.11169347912073135, -0.04829347878694534, 0.2552192807197571, 0.47942236065864563, -0.36731085181236267, 0.38350576162338257, -0.19127483665943146, -0.3379046618938446, -0.019736748188734055, 0.07963208854198456, -0.18718962371349335, 0.203757181763649, -0.13600040972232819, 0.5696767568588257, -0.2138705849647522, -0.3726431429386139, 0.05569656938314438, -0.48500972986221313, 0.2316504269838333, 0.25936174392700195, 0.4961594045162201, -0.015350839123129845, 0.49843740463256836, -0.8101856708526611, -0.036053914576768875, 0.12507298588752747, -0.210597962141037, -0.1858614683151245, -0.529975950717926, 0.6179655194282532, 0.643852174282074, 0.09709981828927994, 0.34449541568756104, 0.5212961435317993, -0.3821928799152374, 0.6435615420341492, -0.6847218871116638, 0.3359268009662628, -0.6012921929359436, -0.14830203354358673, -0.22383414208889008, -0.3269549608230591, 1.1651743650436401, 0.19363874197006226, -0.3784966766834259, -0.2348613440990448, -0.008768433704972267, 0.38969093561172485, 0.23036342859268188, -0.3231707215309143, 0.1283571422100067, -0.39507603645324707, -0.47515758872032166, -0.3599694073200226, 0.3814273774623871, -0.08325636386871338, 0.3944939970970154, -0.2683852016925812, 0.4002612233161926, 0.13869862258434296, -0.49859803915023804, 0.14802539348602295, 0.0026589545886963606, 0.11751624196767807, -0.6480337381362915, 0.1578645259141922, -0.4776899814605713, 0.05077628418803215, -0.37324297428131104, 0.20758041739463806, -0.06968853622674942, -0.43440309166908264, 0.26753804087638855, -0.13041965663433075, -0.2634485960006714, 0.29456350207328796, 0.1269676387310028, 0.17625024914741516, -0.30708107352256775, -0.28377336263656616, -0.5317818522453308, 0.16556012630462646, 0.057627271860837936, -0.27527469396591187, 0.09819189459085464, -0.2963622808456421, -0.17945609986782074, -0.14372849464416504, -0.32496607303619385, -0.2866933345794678, -0.09351997077465057, 0.13913118839263916 ]
Early local tumor invasion in breast cancer results in a likely encounter between cancer cells and mature adipocytes, but the role of these fat cells in tumor progression remains unclear. We show that murine and human tumor cells cocultivated with mature adipocytes exhibit increased invasive capacities in vitro and in vivo, using an original two-dimensional coculture system. Likewise, adipocytes cultivated with cancer cells also exhibit an altered phenotype in terms of delipidation and decreased adipocyte markers associated with the occurrence of an activated state characterized by overexpression of proteases, including matrix metalloproteinase-11, and proinflammatory cytokines [interleukin (IL)-6, IL-1β]. In the case of IL-6, we show that it plays a key role in the acquired proinvasive effect by tumor cells. Equally important, we confirm the presence of these modified adipocytes in human breast tumors by immunohistochemistry and quantitative PCR. Interestingly, the tumors of larger size and/or with lymph nodes involvement exhibit the higher levels of IL-6 in tumor surrounding adipocytes. Collectively, all our data provide in vitro and in vivo evidence that (i) invasive cancer cells dramatically impact surrounding adipocytes; (ii) peritumoral adipocytes exhibit a modified phenotype and specific biological features sufficient to be named cancer-associated adipocytes (CAA); and (iii) CAAs modify the cancer cell characteristics/phenotype leading to a more aggressive behavior. Our results strongly support the innovative concept that adipocytes participate in a highly complex vicious cycle orchestrated by cancer cells to promote tumor progression that might be amplified in obese patients.
[ -0.03630530461668968, 0.005250195506960154, -0.001316228648647666, 0.02702317014336586, 0.015445433557033539, -0.03876268118619919, 0.011143024079501629, -0.0014619790017604828, -0.01851831190288067, -0.014080998487770557, 0.00148690992500633, 0.013995402492582798, -0.0031393705867230892, 0.02616862952709198, -0.02598422020673752, 0.023771194741129875, -0.02078314684331417, -0.034196943044662476, -0.0008562784059904516, -0.002852821256965399, 0.04924320802092552, -0.020687798038125038, 0.010427175089716911, -0.02224235236644745, -0.0024877646937966347, 0.025830181315541267, 0.017268184572458267, -0.02317565679550171, -0.029176242649555206, -0.018241189420223236, -0.005568821914494038, -0.008177784271538258, 0.012110882438719273, -0.009226382710039616, -0.0032950546592473984, 0.004756840877234936, -0.0006523142219521105, 0.024917352944612503, -0.011908003129065037, -0.0030328179709613323, 0.0266891960054636, -0.00949352141469717, 0.00009211222641170025, -0.007860450074076653, -0.010837389156222343, -0.027469241991639137, -0.0011233498807996511, -0.00428750179708004, -0.0007411325350403786, 0.0020662692841142416, -0.004068863578140736, -0.010691300965845585, -0.014627454802393913, 0.027516821399331093, -0.007407838944345713, 0.01008901558816433, 0.02039581909775734, -0.012835679575800896, -0.021290304139256477, -0.007551642134785652, -0.0006900280714035034, -0.039216868579387665, 0.008869520388543606, -0.01577284000813961, 0.02772659622132778, -0.06650573015213013, -0.004405615851283073, 0.015128117986023426, -0.0032388069666922092, -0.01514045987278223, 0.008995195850729942, 0.010089395567774773, 0.01882881671190262, 0.00069774454459548, -0.02622169628739357, 0.00761142373085022, 0.009881976991891861, -0.0355554074048996, 0.01639859564602375, 0.029499687254428864, -0.008125806227326393, -0.010738113895058632, -0.014263797551393509, 0.007092646788805723, 0.01742064207792282, 0.008281396701931953, -0.020948223769664764, 0.0034253480844199657, 0.024531058967113495, 0.010326807387173176, 0.006195070222020149, 0.0007637122180312872, -0.01907043159008026, 0.0031213490292429924, -0.020008213818073273, -0.004789926111698151, -0.013851899653673172, 0.00039618066512048244, 0.044110167771577835, 0.025661952793598175, -0.02790718525648117, -0.008022490888834, 0.02191515453159809, 0.006408687215298414, -0.0028503506910055876, 0.011536452919244766, -0.0020462870597839355, -0.009331073611974716, 0.04402460157871246, 0.01278761401772499, -0.007313805632293224, 0.0048730457201600075, -0.005857184529304504, -0.007619461044669151, 0.00712962169200182, -0.008923036977648735, 0.0023144963197410107, 0.009103908203542233, 0.008785583078861237, -0.01929635927081108, -0.003098862711340189, -0.009388377889990807, -0.004739352036267519, -0.002534697763621807, -0.0006798641406930983, 0.0036045501474291086, 0.005700833164155483, 0.019848987460136414, 0.020560164004564285, -0.002222600858658552, -0.009312358684837818, -0.010610300116240978, -0.007106523495167494, -0.02825915813446045, 0.006952441763132811, 0.010463224723935127, -0.010037938132882118, -0.026546664535999298, -0.01915064826607704, -0.016767749562859535, 0.018973350524902344, 0.007824065163731575, 0.006442048586905003, 0.0060890051536262035, -0.0023689190857112408, -0.005043426528573036, -0.023261509835720062, 0.003786638844758272, 0.010374676436185837, -0.020905494689941406, -0.011633803136646748, -0.0020542035344988108, -0.015362278558313847, -0.013119962066411972, 0.008909262716770172, -0.004961353726685047, 0.011847446672618389, 0.008557159453630447, 0.001543567981570959, -0.011058777570724487, 0.0016120928339660168, -0.04307114705443382, 0.018103376030921936, 0.0094361063092947, 0.009610123001039028, -0.0023037572391331196, -0.01239677332341671, -0.00464087538421154, -0.004389298614114523, 0.004946776665747166, -0.016680322587490082, 0.019980240613222122, -0.00843806006014347, 0.010611012578010559, -0.005973506718873978, 0.005538774188607931, 0.02395254373550415, 0.005080443806946278, -0.014845311641693115, 0.06666881591081619, 0.000511988764628768, 0.012786008417606354, -0.008292892947793007, -0.01263439655303955, -0.005113926250487566, -0.0090025058016181, 0.016614418476819992, -0.00037301465636119246, -0.004123640712350607, -0.007304074242711067, 0.0008940881816670299, 0.009398577734827995, 0.020490780472755432, -0.009192157536745071, -0.04759858921170235, 0.003736049635335803, 0.015841729938983917, 0.012717224657535553, -0.0020520235411822796, -0.010919327847659588, 0.003150411881506443, 0.0003245919942855835, 0.02656671777367592, 0.004359720274806023, -0.014710810035467148, 0.004311513155698776, 0.009457003325223923, -0.02768983319401741, 0.005896527320146561, -0.019107507541775703, 0.01842019334435463, -0.007037709467113018, -0.002977308351546526, -0.01574273407459259, 0.035777896642684937, 0.010030914098024368, 0.001755871344357729, 0.0037004249170422554, -0.02393115684390068, -0.012415293604135513, -0.00575623381882906, 0.015321508049964905, 0.022137006744742393, 0.0028091827407479286, -0.011573173105716705, -0.008902153000235558, 0.013654759153723717, 0.00811483059078455, 0.009400258772075176, -0.008423849008977413, 0.0013080434873700142, -0.015337536111474037, -0.011507214978337288, -0.04274654760956764, 0.006353318691253662, -0.013711001724004745, 0.012195473536849022, -0.01893072947859764, 0.009425933472812176, -0.01264963485300541, 0.0008783616358414292, 0.006123766303062439, 0.020994387567043304, -0.03226113319396973, 0.013524692505598068, 0.015185381285846233, 0.023560194298624992, 0.006683750078082085, -0.0011243075132369995, -0.0179861132055521, 0.008234456181526184, -0.018472490832209587, 0.02198994718492031, -0.00812811590731144, -0.024373557418584824, -0.00894938688725233, -0.03873397782444954, 0.006835306063294411, 0.02615225315093994, -0.006318246480077505, 0.008785659447312355, 0.009591119363904, 0.024125346913933754, 0.006909701973199844, 0.004870802164077759, 0.0010000559268519282, 0.0030686669051647186, 0.022177966311573982, 0.013322943821549416, -0.00032086833380162716, 0.008875156752765179, -0.001483283587731421, -0.0037170054856687784, -0.08114633709192276, -0.012011956423521042, -0.0012872694060206413, 0.0341956727206707, 0.009648742154240608, 0.016201036050915718, 0.012354268692433834, 0.00786603894084692, -0.0033732696902006865, -0.019436314702033997, 0.011933432891964912, 0.009534789249300957, -0.009723052382469177, 0.02260286919772625, -0.01692497730255127, -0.007459627464413643, 0.006054668687283993, -0.024470023810863495, -0.041379280388355255, -0.030091647058725357, 0.02680053561925888, 0.029599128291010857, 0.007796094752848148, -0.006153003312647343, 0.010050213895738125, 0.053562987595796585, -0.0011305492371320724, -0.007974537089467049, 0.0024090472143143415, 0.004098374396562576, 0.013495056889951229, -0.022285521030426025, -0.01997309736907482, 0.011795548722147942, -0.02139071747660637, 0.00005052471533417702, -0.00529645336791873, -0.03453080356121063, -0.01591421291232109, 0.015506204217672348, -0.0029308742377907038, 0.01332090049982071, 0.028548676520586014, -0.01535587478429079, 0.027747299522161484, 0.008507557213306427, 0.008440196514129639, 0.000975937582552433, 0.019482329487800598, -0.008740543387830257, 0.026329876855015755, 0.01463376171886921, 0.010051846504211426, 0.015024160966277122, -0.015029879286885262, -0.014252002350986004, -0.008589163422584534, 0.013211146928369999, -0.016922730952501297, -0.005410419311374426, 0.019959190860390663, -0.026246197521686554, 0.0057230982929468155, 0.013677386566996574, -0.021593619138002396, 0.015295147895812988, 0.01862400397658348, 0.0002540068235248327, -0.011801223270595074, 0.02108008787035942, 0.03714728355407715, 0.017782898619771004, -0.004308232106268406, -0.005993859376758337, 0.004797723144292831, -0.00960429199039936, -0.01677805371582508, -0.004586099646985531, -0.008007850497961044, -0.018255596980452538, -0.020431842654943466, -0.0077313873916864395, -0.003875535447150469, -0.0006730295717716217, -0.008684810250997543, 0.015375199727714062, 0.004473326727747917, 0.04175233095884323, 0.004687989130616188, -0.014938942156732082, 0.0003696405328810215, 0.004700108431279659, 0.012555836699903011, 0.007244742475450039, 0.0187764260917902, -0.004253782797604799, -0.009261352941393852, -0.01425759494304657, -0.003607833757996559, 0.009748491458594799, -0.026557577773928642, 0.0053016068413853645, -0.013046965934336185, -0.009638131596148014, -0.03927868604660034, 0.015448210760951042, 0.02098015323281288, -0.01543259434401989, -0.009046992287039757, -0.0006166664534248412, -0.028766196221113205, -0.01666160114109516, -0.008528666570782661, 0.02802879363298416, 0.015042534098029137, 0.030600152909755707, -0.004812747240066528, -0.007749746087938547, 0.07156117260456085, 0.010950420051813126, -0.009484844282269478, -0.001723353285342455, 0.022772138938307762, -0.04059277102351189, -0.009907227009534836, 0.027634553611278534, -0.02779451757669449, 0.007676464505493641, 0.014080563560128212, -0.012732913717627525, 0.012031825259327888, -0.017348172143101692, -0.0007669106125831604, 0.0024643533397465944, 0.0019575823098421097, -0.01704634726047516, 0.015482896007597446, -0.02428978495299816, -0.03157361224293709, 0.01956905424594879, 0.02193576470017433, -0.016618184745311737, -0.022927671670913696, -0.009360427968204021, 0.006490306928753853, -0.01370919868350029, -0.02356882393360138, 0.004075794480741024, 0.007021517958492041, -0.011510567739605904, -0.004427328705787659, -0.002270427532494068, 0.02348201535642147, 0.010740059427917004, -0.0025692088529467583, -0.0030451142229139805, 0.000012619420886039734, -0.009718102402985096, -0.037189748138189316, -0.013261450454592705, 0.018987126648426056, 0.013244077563285828, -0.009122531861066818, -0.01685308665037155, 0.029426399618387222, -0.0034701654221862555, -0.002044269349426031, 0.009485010989010334, -0.014477287419140339, 0.004793310537934303, 0.01589684560894966, 0.0006759697571396828, -0.008157582953572273, 0.006343093700706959, 0.012517869472503662, 0.0009300037054345012, -0.03631081432104111, -0.0049939947202801704, -0.048352256417274475, -0.008875626139342785, 0.020995968952775, -0.018692338839173317, 0.007017969153821468, 0.0015722457319498062, 0.01498660258948803, -0.0011076823575422168, 0.034273192286491394, -0.018188416957855225, -0.0006183495279401541, 0.00750863179564476, -0.0042075514793396, 0.013767242431640625, -0.005627168342471123, 0.03039882332086563, -0.019068874418735504, -0.013946499675512314, 0.020296521484851837, -0.003034657333046198, 0.0239524245262146, 0.0051642004400491714, 0.020932333543896675, -0.023265276104211807, 0.00026484765112400055, -0.005358840338885784, -0.024362687021493912, -0.0745791643857956, -0.027302835136651993, -0.004070610739290714, -0.005895226262509823, -0.00874220672994852, -0.005829783622175455, -0.012954814359545708, 0.0031755303498357534, -0.013997966423630714, -0.013613599352538586, -0.009325436316430569, -0.010850563645362854, 0.010246909223496914, 0.012716982513666153, 0.014986425638198853, -0.007401273585855961, -0.005282490514218807, -0.008665759116411209, -0.006264014169573784, -0.0005040219984948635, 0.020513370633125305, -0.019151393324136734, -0.009274492040276527, -0.0013961168006062508, -0.007570536807179451, -0.08045788109302521, 0.011283519677817822, -0.01585649885237217, -0.044651396572589874, -0.010713166557252407, -0.03759865090250969, 0.019560672342777252, 0.005285107530653477, -0.01073362771421671, -0.018641455098986626, -0.008633903227746487, -0.0020041409879922867, 0.010746832005679607, -0.0001480133505538106, -0.013631457462906837, -0.0154799222946167, 0.0069748517125844955, -0.038086749613285065, -0.0329011008143425, -0.01764800027012825, 0.0068403263576328754, 0.046437881886959076, -0.010406110435724258, -0.010237030684947968, -0.009312069043517113, -0.038072578608989716, 0.007154952269047499, 0.013005511835217476, 0.018499337136745453, -0.007267797831445932, -0.02152116782963276, -0.014882019720971584, -0.03233977034687996, -0.01628076285123825, -0.020310252904891968, -0.02873970940709114, -0.0003593889996409416, -0.005626368336379528, 0.0199438463896513, -0.0049880389124155045, -0.013794951140880585, 0.011677633970975876, 0.006385256536304951, 0.018993664532899857, -0.003270447254180908, -0.0021915878169238567, 0.0076032658107578754, -0.010989305563271046, 0.01081806793808937, -0.0036094477400183678, 0.006742600817233324, 0.003329730127006769, -0.015587611123919487, 0.007863628678023815, -0.010245261713862419, 0.023937365040183067, -0.0005729594267904758, 0.011862378567457199, 0.00020459340885281563, 0.024362334981560707, -0.015393158420920372, 0.015990285202860832, -0.0033880663104355335, 0.07151864469051361, 0.005441552959382534, 0.006747525651007891, -0.002014281926676631, -0.0036062602885067463, 0.004535640589892864, -0.041972555220127106, -0.006625745445489883, 0.005220660474151373, 0.006306752562522888, 0.01329509261995554, -0.007293335627764463, 0.027083322405815125, 0.010448950342833996, -0.01605299673974514, 0.011608347296714783, -0.0042206719517707825, 0.01777130551636219, -0.025467295199632645, -0.0046939002349972725, -0.033536069095134735, 0.006888753268867731, -0.06777185201644897, -0.03307139500975609, 0.012279801070690155, -0.001615394139662385, -0.04902689903974533, -0.010548550635576248, -0.00017871009185910225, -0.007560537662357092, -0.0034471643157303333, 0.027135107666254044, 0.003313322551548481, -0.005785706453025341, 0.030683886259794235, 0.04129995033144951, -0.004783504642546177, 0.004018396604806185, -0.030177518725395203, -0.02704176865518093, 0.004378878977149725, -0.004049730021506548, 0.0016708713956177235, -0.0019678566604852676, 0.015152010135352612, -0.026555681601166725, 0.003302193246781826, -0.017636988312005997, -0.0423121377825737, 0.01673269085586071, -0.009429647587239742, 0.0016792190726846457, -0.01841116137802601, -0.008424082770943642, 0.007593914866447449, 0.005953983403742313, 0.0010085925459861755, 0.01753336377441883, -0.006685490719974041, 0.01135208085179329, -0.0020725568756461143, -0.00819788221269846, -0.03381134569644928, -0.020423926413059235, 0.02504919469356537, 0.032581865787506104, 0.039404287934303284, -0.0204919520765543, 0.004288072697818279, 0.019230742007493973, 0.002155999420210719, -0.018286995589733124, 0.00602152943611145, -0.007270502392202616, 0.012493587099015713, -0.0035762274637818336, 0.017114026471972466, 0.0120464488863945, 0.01097995974123478, 0.027576971799135208, -0.013908738270401955, 0.026250097900629044, -0.003585798665881157, 0.008374728262424469, -0.03663698211312294, -0.009374547749757767, 0.015337446704506874, 0.001048617996275425, -0.007260729093104601, 0.006589675322175026, -0.0016208086162805557, -0.009277508594095707, -0.004624633118510246, 0.030489841476082802, 0.008145364932715893, 0.03587900474667549, 0.007624667137861252, 0.005156298633664846, 0.01069485954940319, 0.017739679664373398, -0.013421477749943733, 0.0036013396456837654, -0.008161187171936035, -0.010289917699992657, -0.008542237803339958, -0.012427025474607944, -0.009104957804083824, -0.02423146367073059, 0.041431449353694916, 0.026426980271935463, 0.01813529059290886, -0.017517082393169403, 0.03411935269832611, 0.014623199589550495, -0.030904842540621758, 0.05799736827611923, -0.0014234127011150122, 0.03115023300051689, 0.008566043339669704, -0.015658706426620483, 0.0034176805056631565, -0.007137353532016277, -0.0007675203960388899, 0.006724102422595024, 0.030229346826672554, 0.0070716748014092445, -0.011173145845532417, 0.019783098250627518, 0.004624549299478531, 0.006721560377627611, 0.013014987111091614, -0.01273902878165245, 0.0030162986367940903, 0.037323735654354095, -0.006462148856371641, 0.001398326363414526, -0.00520660262554884, -0.0040969704277813435, -0.004511239938437939, 0.04581770673394203, 0.002257531275972724, -0.01363566517829895, 0.0013510978315025568, 0.01939612627029419, 0.008922051638364792, 0.018455514684319496, 0.029633942991495132, -0.019019125029444695, 0.018534153699874878, -0.014342579059302807, 0.023532960563898087, 0.02145540341734886, 0.007931312546133995, -0.005177055485546589, -0.011514382436871529, 0.006932069547474384, 0.010079991072416306, 0.026167962700128555, 0.01809699833393097, 0.003147064708173275, 0.008721309714019299, -0.02947433851659298, -0.002630117814987898, -0.0006743936100974679, 0.007239609025418758, 0.0010394027922302485, -0.007039590738713741, -0.0018351643811911345, 0.0015222516376525164, 0.004579578526318073, -0.003910927101969719, 0.019450195133686066, -0.005765717010945082, 0.020749999210238457, -0.029589802026748657, -0.002421399112790823, -0.03202684596180916, 0.005585857201367617, -0.01539316400885582, 0.008114521391689777, 0.004580628126859665, -0.048651136457920074, 0.01241186074912548, -0.008568305522203445, -0.01678323745727539, 0.0010182466357946396, -0.0017443385440856218, -0.007612376939505339, 0.02816024422645569, -0.0034001432359218597, -0.008823886513710022, -0.04156898707151413, -0.003961627837270498, -0.004675188567489386, -0.02691253274679184, 0.017394794151186943, 0.016563115641474724, -0.03483336791396141, -0.012313975021243095, 0.0003083252813667059, 0.008400149643421173, 0.00042522046715021133 ]
[ -0.07574336230754852, 0.015382698737084866, 0.12204370647668839, -0.03558666259050369, 0.4775068461894989, 0.11060282588005066, 0.19331809878349304, 0.013784642331302166, 0.0834488496184349, -0.6955588459968567, 0.21631678938865662, 0.38162779808044434, -0.08744512498378754, 0.1665058732032776, -0.20231492817401886, 0.5677866339683533, 0.42739689350128174, 0.23142555356025696, -0.2623124122619629, -0.4695379137992859, -0.3224916160106659, -0.46365436911582947, 0.5805701613426208, 0.1222074031829834, 0.40778791904449463, -0.629703938961029, 0.538890540599823, -0.3700979948043823, 0.2304486185312271, -0.4713367819786072, -0.724408745765686, 0.2851557433605194, 0.2550247013568878, -0.10616247355937958, -0.24633605778217316, 0.057605091482400894, -0.10771186649799347, 0.09556026756763458, -0.33772364258766174, -0.058149486780166626, -0.7851307988166809, -0.24006226658821106, -0.015577786602079868, 0.49052292108535767, -0.026877649128437042, -0.27114710211753845, -1.3945016860961914, 0.7715312242507935, -0.09162978082895279, -0.24686622619628906, 0.21481479704380035, 0.13265086710453033, 0.5323233008384705, -0.1763744056224823, 0.210370272397995, -0.2266726940870285, -0.40902262926101685, -0.3409446179866791, 0.3497748374938965, -0.25292932987213135, -0.18359723687171936, 0.3399571478366852, -0.20747807621955872, 0.2091362178325653, 0.098078653216362, 0.7826089262962341, 0.2379819005727768, -0.12868274748325348, -0.21694116294384003, -0.6975815892219543, -0.2468400001525879, -0.46008172631263733, 0.11816432327032089, 0.3431672155857086, -0.2028314769268036, 0.2888810634613037, 0.007712885271757841, -0.33426156640052795, 0.14722377061843872, -0.0463041290640831, -0.027648186311125755, -0.15025591850280762, 0.6111416220664978, -0.3348159193992615, 0.6062241792678833, -0.3675413429737091, -0.04190221056342125, 0.6922911405563354, -0.5566825866699219, -0.26997992396354675, -0.09558004140853882, 0.108952596783638, 0.3769007623195648, 0.21943387389183044, 0.23484671115875244, 0.4588935673236847, -0.13787980377674103, 0.1872500330209732, 0.11812736093997955, 0.29724282026290894, -0.5422208309173584, 0.20856088399887085, 0.016637863591313362, -0.31557542085647583, -0.47642189264297485, -0.377179354429245, -0.1450873762369156, 0.15500466525554657, -1.0907347202301025, 0.28422218561172485, -0.6066386699676514, 0.4707794487476349, -0.005244855303317308, -0.09615188091993332, 0.1576530784368515, -0.14155039191246033, 0.03999525308609009, -0.23485997319221497, -0.006419784855097532, -0.4801371395587921, -0.3031163215637207, 1.6005959510803223, -0.5073006749153137, 0.457328736782074, -0.014298122376203537, 0.05799948424100876, 0.44382357597351074, 0.20736566185951233, -0.10440704226493835, 0.42779839038848877, 0.15317197144031525, 0.5461395978927612, -0.2724262475967407, 0.12181787937879562, 0.0933334156870842, 0.06512370705604553, 0.2983921468257904, 0.45451223850250244, 0.6482599377632141, -0.1640854775905609, -0.4279721975326538, -0.38396787643432617, -0.22935499250888824, 0.5149390697479248, 0.02817455865442753, -0.19183044135570526, 0.3093569576740265, -0.14169426262378693, -0.37428018450737, 0.014161603525280952, 0.22622628509998322, -0.08724034577608109, -0.7259225249290466, -0.031753528863191605, 0.04521079361438751, 0.7607789635658264, -0.013825349509716034, -0.4293072819709778, 0.12872947752475739, 0.6643469333648682, 0.12942573428153992, 0.35632261633872986, -0.4402577877044678, -0.21939462423324585, 0.40155479311943054, -0.3538948595523834, 0.3216695487499237, 0.1896521896123886, 0.31354305148124695, -0.040258973836898804, -0.5265898108482361, -0.08427397906780243, -0.06258686631917953, -0.5104300379753113, -0.25398263335227966, 0.09052913635969162, 0.5494630336761475, -0.08196357637643814, -0.04142918065190315, -0.13171587884426117, -0.7609719634056091, 0.11112849414348602, -0.22081264853477478, -0.26596757769584656, 0.21891646087169647, 0.05281508341431618, 0.4783134460449219, 0.19031348824501038, 0.07486195117235184, 0.08729185163974762, 0.20075853168964386, 0.05368927866220474, 0.40292397141456604, -0.43507149815559387, 1.3659605979919434, 0.17860004305839539, -0.1743081659078598, 0.9676393866539001, 0.24206413328647614, 0.0329391248524189, 0.4004105031490326, 0.11462592333555222, 0.2724263668060303, -0.06975097209215164, -0.5042771697044373, -0.21959897875785828, -0.11495739966630936, -0.6250604391098022, 0.21507583558559418, 0.32939770817756653, 0.23192140460014343, -0.04975145682692528, -0.05178658291697502, 0.004733507055789232, 0.5097495913505554, 0.26776573061943054, -0.03631340339779854, 0.06725988537073135, -0.15686164796352386, -0.19504809379577637, 0.12161914259195328, -0.7246676683425903, 0.6516972780227661, 0.8229376673698425, 0.3468951880931854, 0.5107113122940063, 0.23161722719669342, -0.10700136423110962, 0.653468132019043, -0.28184378147125244, -0.025366853922605515, -0.24867676198482513, 0.00830274447798729, -0.2940472662448883, 0.31119194626808167, 0.18251176178455353, 0.3654944896697998, -0.11106199026107788, -0.23353604972362518, 0.19943340122699738, -0.34586426615715027, 0.38616710901260376, -0.6237409710884094, 0.1926126480102539, -0.09941571205854416, -0.38703545928001404, -0.2518236041069031, 0.029605349525809288, -0.8213624954223633, -0.06852341443300247, -0.05495449900627136, -0.036422885954380035, 0.11520804464817047, -0.7128090262413025, 0.07456515729427338, -0.35460567474365234, -0.3595348000526428, -0.44734933972358704, 0.40072929859161377, -0.4277932643890381, 0.056508928537368774, 0.32988888025283813, 0.20537534356117249, 0.554189145565033, 0.07277344167232513, -0.3048083484172821, -0.6054121255874634, -0.5063351392745972, 0.8788033723831177, 0.5607541799545288, 0.4317241907119751, 0.19511158764362335, -0.9509211778640747, -0.4120948314666748, -0.2505921423435211, -0.4180337190628052, -0.33183449506759644, 0.8812251687049866, -0.14566682279109955, -0.33423447608947754, 0.07740742713212967, 0.45276740193367004, 0.6215255856513977, -0.3789226710796356, -0.53700852394104, -0.012201600708067417, -0.4278137981891632, -0.6430794596672058, -0.6857803463935852, -0.5838477611541748, -0.5484792590141296, 0.3222663700580597, -0.5092565417289734, 0.5914204120635986, 0.4649159610271454, 0.36945801973342896, -0.1380881667137146, 0.38363906741142273, 0.6569759249687195, -0.06507577002048492, -0.11887485533952713, 0.16965079307556152, -0.5466755628585815, 0.11228885501623154, -0.246077761054039, -0.24119822680950165, -0.397533118724823, -0.2030271589756012, -5.878046989440918, 0.06357719749212265, 0.3514042794704437, -0.02887692302465439, 0.009232750162482262, -0.02874796837568283, 0.8228945136070251, 0.1866346001625061, 0.41463786363601685, 0.35283753275871277, 0.031289100646972656, 0.39385271072387695, -0.49507319927215576, -0.040162187069654465, -0.1956174671649933, -0.10863989591598511, -0.13718459010124207, -0.15032164752483368, 0.6515924334526062, -0.09292688220739365, 0.09824937582015991, -0.13410015404224396, 0.16506820917129517, 0.6529370546340942, 0.2360237091779709, 0.2679869830608368, -0.41308313608169556, -0.010139167308807373, -0.19713656604290009, -0.4716736972332001, 0.01011621579527855, -0.8052807450294495, 0.17637595534324646, 0.21973127126693726, 0.1529456079006195, 0.3802662789821625, -0.13727566599845886, 0.18298931419849396, 0.17069126665592194, -0.7686527371406555, 0.28040239214897156, 0.2480996996164322, -0.37278977036476135, 0.3268677890300751, 0.17958198487758636, 0.027701374143362045, 0.14749516546726227, 0.1807284951210022, -0.3401808440685272, 0.872887909412384, 0.005517129320651293, -0.29325616359710693, 0.5518608689308167, 0.704720675945282, 0.3377762734889984, 0.23015737533569336, -0.464234322309494, -0.19888421893119812, -0.41002047061920166, -0.027819285169243813, -0.5390477180480957, -0.2013815939426422, -0.5145107507705688, -0.6991364359855652, 0.17207854986190796, 0.24799664318561554, -0.4110115170478821, -0.23461563885211945, 0.5084689259529114, -0.15579022467136383, -0.08698747307062149, 0.3726813793182373, 0.25432324409484863, -0.6528735160827637, 0.4394235908985138, -0.15589220821857452, -0.3378196060657501, -0.03248744085431099, 0.08001109957695007, -0.18080613017082214, -0.25899064540863037, 0.2655502259731293, 0.18488265573978424, -0.03554224222898483, 0.05285848304629326, -0.22184500098228455, 0.1585092842578888, 0.03373829647898674, -0.053647689521312714, 0.4338203966617584, 0.5532562732696533, -0.10865897685289383, -0.027653969824314117, 0.21212805807590485, 0.3625093698501587, 0.4585302472114563, 0.4645657241344452, 0.2966722548007965, 0.6754056215286255, 0.0875091478228569, 0.797715961933136, 0.10757062584161758, -0.7029706835746765, -0.646926999092102, -0.16291503608226776, 0.5345970392227173, -0.7404784560203552, -0.10776598751544952, 0.6831941604614258, -0.8494910001754761, 0.07555710524320602, 0.1828528791666031, -0.5319217443466187, -0.4090524911880493, 0.27228057384490967, -0.12280061841011047, 0.089488685131073, 0.12398745864629745, 1.030004620552063, -0.5682318210601807, 0.11856776475906372, 0.17014822363853455, -0.19203780591487885, 0.5334568023681641, 0.6793619990348816, -0.4301115572452545, 0.27217984199523926, 0.9752732515335083, -0.9822379946708679, 0.0655532106757164, 0.30664628744125366, 0.29548344016075134, -0.4450457990169525, -0.30251267552375793, 0.2198009043931961, -0.3627949357032776, -0.3838147521018982, -0.03675825893878937, -0.0917120948433876, 0.321545273065567, -0.26829755306243896, -0.43211111426353455, -0.10217371582984924, 0.17292363941669464, 0.2464742511510849, -0.5248988270759583, 0.2281126230955124, 0.13973762094974518, -0.31168150901794434, -0.6016591191291809, 0.11111196130514145, -0.271904855966568, 0.643019437789917, -0.024263795465230942, -0.3763158321380615, -0.03589774668216705, 0.5269635319709778, -0.05776892602443695, 0.022320816293358803, -0.19925636053085327, 0.35167041420936584, 0.0301138274371624, -0.7121135592460632, 0.23670315742492676, -0.2857602536678314, -0.6315295100212097, -0.08871616423130035, -0.4736219048500061, 0.01270823273807764, 0.2380780428647995, -0.1109774187207222, -0.18777969479560852, -0.3448437750339508, -0.05941426008939743, 0.29193854331970215, -0.6015505194664001, -0.3619595468044281, 0.232182115316391, 0.01863880269229412, -0.34565308690071106, 0.29535984992980957, -0.6557340621948242, -0.4811847507953644, 0.2396697700023651, 0.8827321529388428, 0.14285945892333984, -0.2716272473335266, -0.2848808169364929, -0.3064958453178406, -0.4019915759563446, -0.2127039134502411, 0.4739347994327545, 0.3890446424484253, -0.20120622217655182, 0.198635995388031, 0.08599521964788437, 0.15357010066509247, 0.5477086901664734, 0.08381549268960953, -0.3938116729259491, 0.09595692157745361, 0.013698370195925236, -0.6184368133544922, 0.46152567863464355, 0.4133618474006653, 0.2910371422767639, 0.11763021349906921, 0.00992613472044468, -0.13869056105613708, -0.3760412633419037, -0.28298789262771606, -0.7451324462890625, 0.09931793063879013, 0.3940582275390625, -0.11604548990726471, -0.2120768278837204, -0.224456787109375, -0.12952876091003418, -0.30402010679244995, 0.49569016695022583, 0.3504641354084015, -0.19227874279022217, -0.1144946962594986, 0.33568400144577026, -0.551516056060791, 0.34301361441612244, 0.5508934855461121, -0.9154702425003052, 0.3337186574935913, 0.0745297223329544, 0.3386298418045044, -0.22838324308395386, -0.2596530318260193, 0.20462465286254883, -0.15975670516490936, -0.26570746302604675, 0.10349930077791214, 0.08053629845380783, -0.533574640750885, 0.5676074624061584, 0.40422752499580383, 0.7128550410270691, -0.5725107789039612, 0.23054368793964386, 0.03265921398997307, 0.5323011875152588, 0.0017329363618046045, -0.251367449760437, -0.4842759668827057, -0.03372364118695259, 0.5833214521408081, 0.055046629160642624, -0.010559601709246635, 0.20207907259464264, 0.8417965769767761, -0.3311067223548889, -0.7757793664932251, -0.17379409074783325, -0.41897574067115784, 0.31555214524269104, -0.19454026222229004, -0.5511130094528198, 0.18151132762432098, -0.094702810049057, 0.4055176079273224, -0.2033727914094925, -0.2490874081850052, -0.3808935880661011, 0.1428346484899521, -0.30945321917533875, -0.22215642035007477, -0.3525901436805725, 1.0494509935379028, 0.40114620327949524, -0.3539380729198456, 0.04388826712965965, -0.3760398030281067, 0.17705364525318146, 0.03126036748290062, 0.2982151210308075, -0.09643930196762085, -0.5769428014755249, 0.22766084969043732, -0.8172237277030945, 0.37064793705940247, -0.7803660035133362, -0.11509180814027786, -0.5455277562141418, 0.076035276055336, -0.12123754620552063, -0.035405825823545456, 0.06729543209075928, -0.5809642672538757, -0.2679145038127899, -0.02467644028365612, 0.45857399702072144, 0.07737937569618225, 0.2312312126159668, 0.2746283710002899, -0.44439831376075745, -0.5157755613327026, 0.6048829555511475, 0.49120399355888367, -0.579606831073761, 0.024089666083455086, 0.23126602172851562, 0.07247801125049591, 0.16480949521064758, -0.8861833214759827, -0.26305118203163147, 0.07995104789733887, -0.15725356340408325, 0.5781880617141724, -0.08362115174531937, -0.37534967064857483, 0.271806925535202, -0.09770606458187103, -0.5346665978431702, -0.03658738359808922, 0.08889337629079819, 0.09910400956869125, 0.6182386875152588, 0.14948464930057526, -0.09230254590511322, 0.3150901198387146, 0.15438926219940186, 0.19834421575069427, 0.07410816103219986, 0.08583039045333862, 0.1105312779545784, 0.4435919523239136, 0.41155806183815, -0.06307455152273178, 0.8025975823402405, 0.6644840240478516, 0.239328995347023, 0.22135110199451447, -0.8266053795814514, -0.47241613268852234, 0.06245448812842369, 0.6171151399612427, 0.5655179619789124, -0.23725970089435577, -0.3351346552371979, 0.187747523188591, 0.17314572632312775, 0.2649126648902893, 0.40983137488365173, -0.0558190755546093, 0.2737777531147003, 0.19917818903923035, -0.5493587255477905, -0.8279373049736023, 0.3729284703731537, -0.7486808896064758, 0.10887200385332108, 0.5886801481246948, -0.1952124983072281, -0.6439053416252136, -0.11398155987262726, -0.23082290589809418, 0.07301903516054153, -0.11875255405902863, 0.3171147406101227, 0.26516106724739075, -0.04811500757932663, 0.5504107475280762, 0.26522496342658997, 0.2880176901817322, -0.16879630088806152, 0.426328182220459, 0.14195497334003448, 0.07236197590827942, -0.05840373411774635, 0.3063957691192627, -0.5205385684967041, 0.09702321887016296, -0.16540710628032684, -0.07948567718267441, 0.17355135083198547, -0.2615411877632141, 0.3498912453651428, -0.025574497878551483, -0.3443254232406616, -0.3171796202659607, -0.5328056216239929, -0.3561350405216217, -0.015827862545847893, 0.13087905943393707, 0.15709027647972107, 0.11576507985591888, -0.4471001625061035, 0.4819122850894928, 0.33026066422462463, -0.31834274530410767, 0.2549107074737549, -0.26943323016166687, 0.1705770194530487, 0.22267106175422668, 0.36056020855903625, 0.03933486342430115, 0.09257198870182037, -0.17964477837085724, 0.6924623250961304, -0.46176281571388245, 0.724245011806488, -0.6869062781333923, -0.6886693835258484, -0.39632469415664673, 0.23242373764514923, 1.1656951904296875, 0.910677969455719, -0.4255271852016449, -0.0016578572103753686, -0.06399764120578766, 0.1707322746515274, 0.5434960722923279, -0.20147919654846191, -0.05867590010166168, -0.7131317257881165, -0.3464720547199249, -0.5916368961334229, 0.611163318157196, -0.15016932785511017, -0.2351541668176651, -0.375562846660614, 0.5296830534934998, 0.4990249574184418, 0.11664760857820511, 0.13324466347694397, 0.12498468160629272, 0.009982394054532051, -0.6461979150772095, 0.44074055552482605, -0.552584171295166, 0.1646718978881836, -0.1478494554758072, 0.03943157568573952, 0.3891719877719879, -0.04417284578084946, 0.1331203430891037, -0.5518851280212402, 0.3091306984424591, 0.18747538328170776, 0.10999312996864319, -0.010056058876216412, -0.10358161479234695, -0.6902492642402649, -0.5283982157707214, 0.2840252220630646, -0.1594652533531189, -0.5538740158081055, -0.01885611191391945, 0.4075605273246765, -0.5670958161354065, 0.06317698210477829, -0.1902819722890854, -0.5331419706344604, -0.4954964816570282, -0.10381942242383957 ]
AIMS Cardiovascular disease (CVD) is now the most prevalent and debilitating disease affecting the Chinese population. The goal of the present manuscript was to analyse cardiovascular risk factors and the prevalence of non-fatal CVDs from data gathered from the 2007-2008 China National Diabetes and Metabolic Disorders Study. METHODS AND RESULTS A nationally representative sample of 46 239 adults, 20 years of age or older, was randomly recruited using a multistage stratified design method. Lifestyle factors, diagnosis of CVD, stroke, diabetes, and family history of each subject were collected, and an oral glucose tolerance test or a standard meal test was performed. Various non-fatal CVDs were reported by the subjects. SUDAAN software was used to perform all weighted statistical analyses, with P < 0.05 considered statistically significant. The prevalence of coronary heart disease, stroke, and CVDs was 0.74, 1.07, and 1.78% in males; and 0.51, 0.60, and 1.10% in females, respectively. The presence of CVDs increased with age in both males and females. The prevalence of being overweight or obese, hypertension, dyslipidaemia, or hyperglycaemia was 36.67, 30.09, 67.43, and 26.69% in males; and 29.77, 24.79, 63.98, and 23.62% in females, respectively. In the total sample of 46 239 patients, the prevalence of one subject having 1, 2, 3, or ≥4 of the 5 defined risk factors (i.e. smoking, overweight or obese, hypertension, dyslipidaemia, or hyperglycaemia) was 31.17, 27.38, 17.76, and 10.19%, respectively. Following adjustment for gender and age, the odds ratio of CVDs for those who had 1, 2, 3, or ≥4 risk factors was 2.36, 4.24, 4.88, and 7.22, respectively, when compared with patients with no risk factors. CONCLUSION Morbidity attributed to the five defined cardiovascular risk factors was high in the Chinese population, with multiple risk factors present in the same individual. Therefore, reasonable prevention strategies should be designed to attenuate the rapid rise in cardiovascular morbidity.
[ -0.01960981823503971, 0.016084089875221252, -0.012342022731900215, 0.02676745131611824, -0.0167046207934618, -0.02082648128271103, 0.008896112442016602, 0.008819674141705036, -0.01131395809352398, -0.016358455643057823, -0.0021403280552476645, 0.008520764298737049, -0.0006280430825427175, 0.017012130469083786, 0.010099520906805992, 0.003629971295595169, -0.024978511035442352, 0.019451020285487175, 0.01100856438279152, -0.016542818397283554, 0.014500081539154053, -0.006454536225646734, 0.00986877828836441, 0.020331785082817078, -0.01753907836973667, 0.0022402219474315643, 0.031027207151055336, -0.0026090643368661404, -0.008921016938984394, 0.006920937914401293, 0.007761024404317141, 0.02052491158246994, -0.010198725387454033, 0.02260979637503624, 0.000880473991855979, -0.0012920442968606949, 0.006397837772965431, 0.012300918810069561, 0.005475505720824003, -0.00526911998167634, 0.01815693825483322, -0.0071307457983493805, 0.0033971501979976892, 0.014097625389695168, -0.007025127299129963, 0.011352933943271637, -0.008887337520718575, 0.001708772499114275, 0.009279627352952957, 0.016440412029623985, -0.011844154447317123, -0.008117549121379852, -0.009179524146020412, -0.031781502068042755, -0.006314083933830261, -0.03514774143695831, 0.017433639615774155, 0.004196079447865486, 0.0013028709217905998, 0.012673390097916126, -0.013505094684660435, -0.013514322228729725, -0.005978349596261978, 0.00483717629685998, -0.024613965302705765, -0.06697478145360947, -0.011179102584719658, 0.025791555643081665, 0.009100123308598995, -0.011735215783119202, -0.0014457842335104942, 0.0024344471748918295, 0.042483046650886536, 0.011861667037010193, -0.006397312507033348, 0.0024663573130965233, 0.019636161625385284, 0.03499796614050865, 0.015181667171418667, -0.014996795915067196, -0.011041181161999702, 0.00866661686450243, -0.010235071182250977, 0.031022056937217712, 0.009599622339010239, 0.002266422612592578, -0.012194887734949589, -0.014935768209397793, 0.008478960022330284, 0.005580062046647072, 0.011542017571628094, -0.03331388533115387, 0.012675824575126171, -0.006880858447402716, -0.04746314883232117, -0.01843944564461708, 0.0025856774300336838, 0.020171627402305603, -0.0040810867212712765, -0.01303255558013916, -0.001113757025450468, -0.039281219244003296, 0.016342706978321075, 0.018737629055976868, -0.036469489336013794, 0.006518770009279251, -0.026043418794870377, -0.020436067134141922, 0.012852629646658897, 0.002897827187553048, 0.002756306668743491, 0.01766544207930565, 0.02771858498454094, 0.013210572302341461, 0.0067606414668262005, 0.033086374402046204, 0.00392256211489439, -0.00022969325073063374, 0.00486733065918088, 0.00039163907058537006, -0.020627036690711975, 0.018709179013967514, -0.0071341851726174355, 0.018432483077049255, -0.002876743907108903, -0.008619298227131367, 0.011465000919997692, -0.0002516806125640869, -0.005350172519683838, 0.0017911681206896901, -0.0077762664295732975, -0.006571553181856871, -0.023372385650873184, 0.010972898453474045, 0.005334025714546442, -0.0021918760612607002, -0.019226020202040672, -0.004548498895019293, -0.02523571439087391, -0.022096656262874603, -0.023629069328308105, 0.004622531123459339, -0.0018412042409181595, 0.006597102619707584, 0.009925732389092445, -0.004371806979179382, -0.015134946443140507, 0.014507271349430084, 0.027291947975754738, 0.004938904661685228, -0.015437427908182144, -0.003701540408656001, 0.011252348311245441, -0.02440488710999489, -0.025308340787887573, -0.010935426689684391, 0.0035016946494579315, 0.001804249593988061, 0.010332056321203709, 0.012125305831432343, -0.014592042192816734, -0.018536746501922607, 0.0181535966694355, 0.00836404599249363, 0.02907930314540863, 0.017207054421305656, -0.0035245264880359173, -0.01528088003396988, -0.010888289660215378, 0.006037185899913311, -0.004878540523350239, 0.012939702719449997, -0.02159649319946766, 0.015543170273303986, -0.0026588800828903913, -0.0063272337429225445, -0.00405574357137084, 0.00867158081382513, -0.008602507412433624, 0.06647667288780212, 0.005956847686320543, 0.0016332888044416904, -0.009045024402439594, -0.006586662493646145, 0.017509032040834427, -0.024538129568099976, -0.0032601035200059414, -0.014149713329970837, -0.0027292303275316954, -0.023078564554452896, -0.01064436137676239, 0.0299411341547966, 0.005815383978188038, 0.005544404033571482, -0.014265375211834908, 0.0033833119086921215, 0.000559562467969954, 0.00907793827354908, 0.01994556002318859, 0.03188138082623482, 0.0028754137456417084, 0.005314880982041359, 0.022487955167889595, -0.006064079236239195, -0.01739751175045967, 0.013568614609539509, 0.01751331239938736, -0.0032397755421698093, -0.003929308615624905, 0.005059627816081047, 0.013665326870977879, 0.014303484000265598, 0.0101371044293046, -0.0015328505542129278, 0.003360595554113388, -0.018154054880142212, -0.028342727571725845, 0.022188939154148102, -0.003917694091796875, -0.015803933143615723, -0.00269039673730731, 0.0006008679047226906, -0.00840507261455059, 0.029364529997110367, 0.007132325321435928, -0.005376478191465139, -0.00697055971249938, 0.007558396551758051, 0.015909146517515182, -0.004119428806006908, -0.006192072294652462, -0.0031633777543902397, -0.007392949424684048, -0.02682880312204361, 0.01415977068245411, -0.006538607180118561, 0.014854726381599903, -0.012826760299503803, 0.0036605806089937687, -0.017605416476726532, -0.015408001840114594, -0.027121517807245255, 0.01875118725001812, 0.006587568670511246, 0.029506828635931015, -0.0003075478598475456, -0.011021684855222702, -0.0036252629943192005, 0.002588227391242981, -0.006977551616728306, 0.006796630565077066, -0.010592184960842133, 0.018257055431604385, -0.012841945514082909, 0.013891249895095825, -0.01503081526607275, 0.009625261649489403, -0.027874097228050232, 0.02410409040749073, -0.015119572170078754, 0.01725711300969124, 0.010400732979178429, -0.017877085134387016, 0.004588122013956308, -0.020632386207580566, -0.02314101718366146, 0.014278906397521496, 0.019769618287682533, -0.0032859996426850557, -0.011820737272500992, 0.0092184292152524, -0.00827547162771225, 0.0038715843111276627, -0.08138209581375122, -0.009242376312613487, -0.003033266169950366, -0.005354745779186487, 0.004311174154281616, 0.012750625610351562, 0.010007363744080067, 0.004100248217582703, -0.009018494747579098, -0.01950051449239254, 0.00669536367058754, -0.003130254102870822, -0.002146041952073574, 0.044222403317689896, 0.00653744675219059, -0.005672442261129618, 0.005950446240603924, 0.021077360957860947, -0.004505443852394819, -0.008402755483984947, 0.0033994344994425774, 0.025568317621946335, 0.02522742748260498, -0.017322197556495667, -0.01707308180630207, 0.002829513978213072, 0.022676970809698105, -0.004696234129369259, -0.033886685967445374, 0.014014961197972298, -0.0035544848069548607, -0.023120492696762085, 0.008154626004397869, -0.016258832067251205, -0.04509315639734268, -0.01763445883989334, -0.002240502741187811, -0.00030486565083265305, -0.016967827454209328, 0.004280809313058853, 0.00327377044595778, 0.01825612410902977, -0.0008040268439799547, -0.007970398291945457, -0.0019228621385991573, -0.018717769533395767, 0.005641551688313484, -0.0069469185546040535, 0.021652478724718094, -0.020192701369524002, -0.0009390143677592278, -0.007898627780377865, 0.03475487604737282, 0.011462568305432796, -0.013122737407684326, -0.01948617771267891, 0.000815442530438304, 0.010818788781762123, -0.013898901641368866, -0.01430878508836031, -0.02798421122133732, -0.02014925144612789, -0.003479829989373684, 0.004219557624310255, 0.004744482692331076, -0.004349368158727884, 0.010510178282856941, 0.011765607632696629, -0.015728559345006943, -0.00734985014423728, 0.0163603313267231, -0.004490867722779512, 0.013873780146241188, -0.011511113494634628, 0.02096174657344818, -0.003739314153790474, -0.02068876288831234, 0.01651872508227825, 0.019376646727323532, 0.0014951579505577683, -0.00046308478340506554, 0.001154123106971383, 0.003819040022790432, 0.02136363461613655, -0.00004202709533274174, -0.015276696532964706, 0.01623847521841526, 0.03193943575024605, 0.018694493919610977, -0.011721797287464142, -0.005173281766474247, 0.03604304790496826, -0.007460939697921276, 0.009662850759923458, -0.002916232217103243, 0.007501527667045593, 0.02410551905632019, 0.004128352273255587, -0.002380753168836236, 0.007825501263141632, 0.0028904490172863007, -0.0066611273214221, -0.020616760477423668, -0.012170713394880295, -0.009247541427612305, 0.01452986616641283, 0.0052292305044829845, -0.0036354083567857742, -0.0037833533715456724, -0.003398298751562834, -0.015772860497236252, 0.011850138194859028, -0.003967050928622484, 0.014108255505561829, 0.01744168810546398, 0.0398603118956089, 0.004983250517398119, -0.006136718671768904, 0.07260556519031525, 0.009260457009077072, 0.015156876295804977, -0.012182640843093395, 0.0082621518522501, -0.019621146842837334, -0.028519397601485252, 0.011049950495362282, 0.030075298622250557, -0.00020361365750432014, 0.01139700599014759, -0.016483251005411148, 0.006357722915709019, -0.004954046569764614, -0.009535202756524086, 0.01612015627324581, -0.002291599288582802, -0.0038988101296126842, -0.014692004770040512, -0.004980030003935099, 0.014721350744366646, 0.008066789247095585, 0.0024561192840337753, 0.00562686612829566, 0.02564244158565998, -0.0016016799490898848, -0.011732416227459908, -0.011836249381303787, -0.008220714516937733, 0.00879384484142065, 0.012172166258096695, 0.029924357309937477, -0.006351631134748459, 0.016749385744333267, -0.026944218203425407, -0.009483729489147663, -0.002814381616190076, -0.00949679221957922, 0.015115463174879551, -0.01002911850810051, -0.018721703439950943, -0.012074388563632965, 0.020116688683629036, 0.0006920693558640778, -0.017119495198130608, 0.018634270876646042, 0.005755964200943708, -0.007329251617193222, -0.03201983869075775, -0.009212296456098557, 0.0002511019119992852, -0.005496369209140539, 0.01177217811346054, 0.011569848284125328, -0.0070117320865392685, -0.02055707573890686, -0.023903921246528625, -0.011706504970788956, -0.01941567286849022, -0.013314977288246155, -0.002891269512474537, -0.03193506598472595, 0.015757225453853607, -0.035545140504837036, -0.026156213134527206, 0.006680441088974476, 0.027831805869936943, -0.006921576801687479, -0.026284540072083473, 0.007956544868648052, -0.0029706605710089207, 0.0076859500259160995, -0.0007950500585138798, -0.011398321948945522, -0.017209261655807495, -0.01137961633503437, -0.017916452139616013, 0.006909009534865618, 0.018250279128551483, -0.014673944562673569, 0.00039413198828697205, 0.01279014814645052, 0.02891390025615692, -0.021244598552584648, 0.02250627428293228, 0.0057501401752233505, -0.021990951150655746, -0.0749509334564209, -0.013524522073566914, 0.00329993455670774, -0.009556198492646217, -0.008207347244024277, 0.011070375330746174, -0.028132827952504158, -0.005440833047032356, -0.03543948382139206, -0.006221037358045578, 0.0035620364360511303, 0.013799640350043774, -0.014089790172874928, -0.014672894962131977, 0.014870179817080498, -0.006981826387345791, -0.011781252920627594, 0.004328829236328602, 0.0054046823643147945, 0.026870086789131165, 0.02829623967409134, 0.016151035204529762, -0.025533638894557953, -0.01338701881468296, -0.011040262877941132, -0.08152540028095245, 0.0033760452643036842, 0.004737600684165955, -0.026566237211227417, -0.014745030552148819, 0.0075500719249248505, 0.01673249527812004, 0.005358116701245308, 0.0030550684314221144, -0.014271331951022148, -0.00264023058116436, 0.009677000343799591, 0.00478541711345315, 0.00576810771599412, -0.018965141847729683, -0.00539983157068491, 0.007529742084443569, 0.006698506884276867, -0.007505794055759907, -0.015496442094445229, 0.010446012020111084, 0.020699098706245422, -0.004773866385221481, 0.016314789652824402, -0.010045871138572693, -0.03583381697535515, 0.002029973780736327, 0.008035324513912201, 0.01476062647998333, 0.0010838480666279793, 0.0269172303378582, 0.0163419209420681, -0.017270708456635475, -0.0010144412517547607, 0.006100167520344257, -0.020188644528388977, 0.01139096450060606, 0.0014742431230843067, 0.012577882036566734, -0.004691258072853088, -0.004800180904567242, 0.0017045694403350353, -0.007209097035229206, -0.007804904133081436, 0.011759087443351746, 0.01072510052472353, 0.010350510478019714, -0.014766810461878777, 0.00572649110108614, -0.015796100720763206, 0.007656167261302471, -0.015029126778244972, 0.00038459012284874916, 0.0010241982527077198, 0.011245401576161385, -0.004210426937788725, -0.015104604884982109, 0.0029659969732165337, 0.00402046600356698, 0.01112576574087143, -0.005857483018189669, 0.008182547986507416, -0.002980242483317852, 0.07175233215093613, -0.029834700748324394, -0.003867129096761346, 0.003721552900969982, -0.006106110755354166, 0.0029201011639088392, -0.0036673371214419603, 0.0014919694513082504, 0.00926978513598442, 0.0025227051228284836, -0.006007085088640451, -0.0020958161912858486, 0.016465308144688606, 0.012347890064120293, -0.013641225174069405, 0.00824916921555996, 0.019065789878368378, -0.019361820071935654, -0.020076744258403778, -0.0030394652858376503, 0.005653721280395985, 0.013855366967618465, -0.020561320707201958, 0.0008525820448994637, 0.003395991399884224, -0.0018143625929951668, -0.003921523690223694, -0.006907095666974783, 0.006554042920470238, 0.010927258059382439, -0.011809280142188072, -0.0005987787153571844, 0.010059826076030731, 0.01100395992398262, 0.008404293097555637, -0.0034654177725315094, 0.0049669500440359116, 0.007947096601128578, -0.012267610058188438, 0.00859481655061245, 0.014637799933552742, -0.011956697329878807, 0.011504953727126122, -0.0010456922464072704, 0.04562973976135254, 0.003433765610679984, 0.003359199268743396, -0.0018040072172880173, -0.015297424048185349, 0.009242432191967964, 0.002037422265857458, -0.0020754393190145493, 0.011845683678984642, -0.0007472059223800898, -0.006976721808314323, 0.0019272617064416409, -0.007597547024488449, 0.017711304128170013, 0.014451252296566963, -0.00423759501427412, 0.003035851987078786, -0.0036881042178720236, 0.004682513419538736, -0.011076781898736954, -0.002327796770259738, -0.021359626203775406, 0.02350471168756485, -0.00851539708673954, -0.0036326961126178503, 0.007720076013356447, 0.02736104466021061, 0.018278535455465317, 0.011110938154160976, 0.009847203269600868, 0.000604516826570034, -0.0022067129611968994, -0.007222500164061785, -0.018734173849225044, 0.025069324299693108, 0.020813152194023132, -0.010744054801762104, -0.005925534293055534, -0.008074512705206871, -0.04346633702516556, -0.005766807124018669, 0.0014071112964302301, 0.004439350217580795, 0.009635831229388714, -0.01163043174892664, 0.0013201056281104684, 0.001263102749362588, -0.008942646905779839, 0.005246669985353947, 0.014031756669282913, 0.011145010590553284, 0.03397995978593826, -0.008504782803356647, 0.005900087766349316, 0.003749124240130186, -0.0024604557547718287, 0.012098081409931183, -0.025911178439855576, -0.0007792217656970024, 0.01971723884344101, -0.0009766063885763288, 0.007795450743287802, 0.00677493866533041, -0.02939874865114689, 0.015353946946561337, 0.030068200081586838, -0.008079973980784416, -0.013867021538317204, 0.010020904242992401, 0.04260989651083946, -0.005593451671302319, 0.03360534831881523, -0.0036972444504499435, 0.013606849126517773, 0.00850743893533945, -0.020842313766479492, 0.012504639104008675, -0.011944741010665894, 0.01822485961019993, 0.02497876062989235, -0.03041822277009487, -0.0007649128092452884, -0.008716758340597153, -0.0011026635766029358, 0.014540490694344044, -0.003320005489513278, 0.02477889135479927, 0.007226998917758465, -0.008486147969961166, 0.001471315510571003, 0.011983251199126244, -0.04132690280675888, -0.03042609617114067, 0.009130368009209633, -0.01572854444384575, -0.00337703013792634, 0.018569912761449814, 0.0046332478523254395, 0.006203079596161842, -0.01160970889031887, 0.008837636560201645, 0.018132206052541733, -0.0021692621521651745, 0.01557133998721838, 0.01553252711892128, 0.004980742931365967, -0.014589454978704453, -0.006798124872148037, 0.008254962973296642, -0.0027657398022711277, -0.0012884531170129776, 0.006732061505317688, 0.004825830925256014, 0.0022460883483290672, -0.004290779121220112, -0.005858887918293476, -0.008914761245250702, -0.03257365897297859, -0.007104658521711826, 0.010685078799724579, 0.012327242642641068, 0.005793801974505186, -0.0157043244689703, -0.0014695691643282771, -0.007064523175358772, 0.0069688307121396065, 0.019463567063212395, 0.002329337876290083, -0.012349080294370651, 0.014029869809746742, -0.0008486027363687754, -0.005349719896912575, 0.014661714434623718, 0.002051265211775899, -0.01761026866734028, 0.015151670202612877, 0.004987889900803566, -0.03632216155529022, 0.004334313794970512, -0.009948696941137314, -0.0004776262794621289, -0.008801668882369995, -0.015173573978245258, 0.006831480655819178, 0.0037103435024619102, -0.015190200880169868, -0.009243002161383629, -0.015108920633792877, -0.002534065395593643, 0.0016710516065359116, -0.006120888516306877, 0.007308940403163433, -0.007368049584329128, 0.005546126514673233, -0.0013607435394078493, 0.01721062883734703, 0.006456802599132061, -0.0006934581324458122 ]
[ 0.24042607843875885, 0.303166002035141, 0.09696701914072037, -0.3562527298927307, 0.08703216165304184, 0.17216534912586212, 0.06742741912603378, 0.049537889659404755, -0.04913954436779022, -0.11946257948875427, -0.0762484222650528, -0.029473276808857918, 0.057647302746772766, -0.25533005595207214, -0.15753291547298431, 0.44428470730781555, 0.26235708594322205, 0.28090816736221313, -0.33621761202812195, -0.18902915716171265, -0.3240128457546234, -0.17800794541835785, 0.568306028842926, 0.06939072906970978, 0.05075380206108093, 0.39375191926956177, 0.8004904389381409, -0.17540588974952698, -0.10273655503988266, -0.1305818408727646, -0.18621383607387543, 0.5130223631858826, 0.3981153666973114, -0.29918232560157776, -0.343527615070343, 0.2277163863182068, -0.4299733638763428, 0.18265140056610107, -0.09044701606035233, -0.17687778174877167, -0.3300023376941681, -0.10768131166696548, -0.00526535464450717, 0.3806730806827545, 0.2323397397994995, -0.8462253212928772, -1.5307434797286987, 0.14813411235809326, -0.4260592460632324, -0.17144793272018433, 0.21176625788211823, -0.09494715183973312, 0.18902869522571564, 0.16652466356754303, 0.0929209291934967, 0.339428186416626, -0.7114829421043396, -0.43146228790283203, -0.22942118346691132, -0.05771917477250099, 0.31171485781669617, -0.026963911950588226, 0.12288148701190948, 0.6190491318702698, -0.16421198844909668, 0.3737069070339203, -0.10678573697805405, 0.4168563783168793, -0.07396367937326431, -0.6131791472434998, 0.13318026065826416, -0.1844950020313263, -0.4966924786567688, 0.2527230978012085, -0.4408852458000183, -0.44529989361763, -0.30162283778190613, -0.008702955208718777, 0.4624474346637726, -0.17965660989284515, 0.4242405295372009, -0.0707961767911911, 0.251566618680954, -0.18689976632595062, 0.32315176725387573, 0.20914876461029053, -0.05092832073569298, 0.27215415239334106, 0.015638252720236778, 0.5584450364112854, 0.05276300758123398, -0.0696222111582756, 0.7822115421295166, 0.42320716381073, 0.09578246623277664, 0.18105752766132355, 0.1951277107000351, 0.13267606496810913, 0.07777494192123413, 0.1560007929801941, -0.11465168744325638, 0.38202667236328125, -0.08631198108196259, -0.2276354432106018, -0.40980175137519836, 0.16904443502426147, 0.03390907496213913, -0.38325798511505127, -0.39122891426086426, -0.07316981256008148, -1.1553480625152588, 0.09866614639759064, -0.0889248326420784, -0.06179210543632507, -0.2883552312850952, 0.36918386816978455, 0.013355775736272335, -0.6633661389350891, 0.1060570552945137, -0.10637912899255753, 0.15368226170539856, 0.7579434514045715, -0.17984995245933533, -0.04568105563521385, 0.638949990272522, 0.29049789905548096, 0.38209807872772217, 0.32676512002944946, -0.1115034893155098, 0.8087918758392334, 0.20536427199840546, 0.0008984003216028214, -0.4084627330303192, -0.15447252988815308, -0.18841473758220673, -0.011622740887105465, 0.22164423763751984, 0.24675463140010834, 0.1766412854194641, 0.02218017727136612, -0.5881486535072327, -0.5814224481582642, -0.25340989232063293, -0.15645107626914978, -0.16604137420654297, 0.08493851870298386, -0.48516327142715454, -0.15286371111869812, -0.5652265548706055, -0.5147038102149963, 0.13260017335414886, -0.4760991632938385, -0.37219002842903137, -0.2984812557697296, -0.011453574523329735, 0.6477450728416443, 0.4011212885379791, -0.12009412050247192, 0.2862626314163208, -0.011986506171524525, 0.5754920840263367, 0.060942355543375015, -0.3610227406024933, 0.13158191740512848, 0.46691322326660156, 0.01676790788769722, -0.03722681477665901, 0.28046852350234985, 0.17078788578510284, -0.028950238600373268, -0.6058601140975952, -0.17789602279663086, -0.005524940323084593, -0.466066837310791, -0.3089417815208435, 0.08488663285970688, 0.2746694087982178, 0.42067012190818787, 0.2873910963535309, 0.2055308073759079, -0.6827332973480225, 0.37701040506362915, 0.2520458996295929, -0.5460925698280334, -0.08802980929613113, -0.21719428896903992, 0.08914928883314133, 0.09181205928325653, 0.23642700910568237, 0.6688151955604553, -0.5576911568641663, -0.3049014210700989, 0.7419096231460571, -0.5632227659225464, 0.8191757798194885, -0.30416610836982727, 0.04978172108530998, 1.3534327745437622, -0.4791606068611145, 0.14960195124149323, -0.07806183397769928, 0.48783931136131287, 0.41698384284973145, 0.007363136392086744, -0.7460347414016724, -0.12924142181873322, -0.0399881936609745, 0.2575136125087738, -0.40333884954452515, 0.2072681337594986, 0.24140098690986633, -0.2511996626853943, -0.13348416984081268, -0.19828130304813385, 0.2200915366411209, 0.1340341418981552, -0.2876887023448944, 0.04595421999692917, 0.02588624507188797, -0.30899563431739807, 0.7172549962997437, -0.6111159920692444, 0.193630650639534, 0.3607490360736847, 0.32915398478507996, 0.714256763458252, 0.7999275326728821, -0.1774163693189621, 0.46320369839668274, -0.5852721333503723, 0.32140764594078064, -0.27162477374076843, 0.6908022165298462, -0.30985891819000244, -0.019404664635658264, 0.23633995652198792, -0.5248645544052124, -0.5483196377754211, 0.17656831443309784, -0.05978269502520561, 0.4573881924152374, -0.28836607933044434, -0.15782220661640167, -0.046579908579587936, -0.03282250463962555, -0.33765968680381775, -0.6025469303131104, 0.007667209953069687, -0.5748304724693298, 0.06149407476186752, -0.002671475289389491, 0.34043049812316895, 0.16302312910556793, 0.08527671545743942, 0.14868144690990448, 0.3250049650669098, 0.3041725754737854, -0.031886521726846695, 0.1115860566496849, -0.284572958946228, -0.11481425166130066, 0.008199429139494896, 0.24362654983997345, 0.4178580045700073, 0.22450102865695953, -0.6291853785514832, -0.17198486626148224, -0.29375651478767395, 0.451862633228302, 0.6799657344818115, 0.7640727162361145, 0.11584524065256119, -0.5423510670661926, 0.43399113416671753, -0.29572397470474243, -0.9011596441268921, 0.2921906113624573, 0.6770160794258118, -0.6892796754837036, -0.24361641705036163, -0.07904710620641708, 0.16450807452201843, 0.37334713339805603, -0.5210753083229065, 0.08808955550193787, -0.0303092859685421, -0.24478323757648468, -0.12414208799600601, -0.4399339556694031, 0.2834465205669403, 0.25517159700393677, 0.5275824069976807, -0.027874354273080826, -0.547747015953064, 0.32160958647727966, -0.2721560001373291, -0.15856611728668213, 0.6980816721916199, 0.7740960121154785, -0.07892584055662155, -0.017132066190242767, 0.29047125577926636, -0.0075121354311704636, -0.2615255117416382, 0.03862437978386879, 0.15547966957092285, -0.11383961886167526, 0.48149311542510986, -6.098702907562256, -0.055277545005083084, -0.41517752408981323, -0.20971781015396118, -0.26760444045066833, 0.016913792118430138, 0.5917940139770508, -0.3367478549480438, -0.3706674575805664, 0.045565616339445114, 0.7273298501968384, 0.3569030463695526, 0.29315218329429626, 0.06599386781454086, -0.25955629348754883, 0.391231507062912, -0.053790584206581116, -0.07411126792430878, 0.6555437445640564, -0.1295880228281021, 0.42238444089889526, -0.7426512837409973, 0.011600283905863762, 1.1606593132019043, -0.02044297754764557, 0.5131477117538452, -0.5057531595230103, 0.5379937291145325, -0.15257537364959717, -0.2860053777694702, 0.3089894652366638, -0.7139996290206909, -0.16250687837600708, 0.05427081510424614, -0.004667376168072224, -0.24697430431842804, 0.3977402150630951, 0.11107705533504486, -0.2949095070362091, 0.07874570786952972, 0.05591355264186859, -0.10626407712697983, -0.15924634039402008, -0.14123693108558655, -0.1984020173549652, -0.4907975494861603, 0.3351895809173584, 0.5249950885772705, -0.4815692901611328, 0.3762608766555786, 0.505990743637085, -0.2725452184677124, -0.0778404250741005, 0.6730358600616455, 0.15839159488677979, -0.1725294589996338, -0.12849164009094238, 0.48385658860206604, -0.49809950590133667, 0.4277603328227997, 0.3409070074558258, 0.10255686193704605, 0.09384438395500183, -0.6610193848609924, -0.1548529416322708, 0.23642240464687347, -0.27469027042388916, -0.47166067361831665, -0.1849319487810135, 0.08997168391942978, -0.7112618684768677, -0.05618462339043617, 0.00791635550558567, -0.7507949471473694, -0.07067567110061646, -0.1803297996520996, 0.3120740056037903, -0.052575401961803436, 0.04164993017911911, -0.05951901152729988, 0.1302097737789154, -0.18054287135601044, 0.32725656032562256, -0.028839465230703354, 0.23079706728458405, -0.28105229139328003, 0.0749138742685318, 0.40213966369628906, 0.20091071724891663, 0.3506394624710083, 0.2256205826997757, -0.28101083636283875, 0.1845247447490692, 0.3052136301994324, 0.4622407555580139, 0.36820316314697266, 0.4568530321121216, -0.17630916833877563, 0.5190945863723755, -0.2522226572036743, 0.43982645869255066, 0.26356762647628784, -0.44589629769325256, -0.8371407389640808, -0.23810066282749176, -0.15200835466384888, -0.12104777991771698, -0.026211727410554886, 0.855343759059906, -0.8928748369216919, 0.17546281218528748, -0.06975196301937103, 0.022177202627062798, -0.1973268687725067, 0.3952522277832031, -0.5035192966461182, 0.1454106718301773, -0.03327846899628639, 0.1333492249250412, 0.16426707804203033, -0.0008758754702284932, -0.028639452531933784, -0.545436441898346, 0.2841885983943939, -0.2613106966018677, -0.3446933627128601, 0.2318238615989685, 0.3268831670284271, -0.6504641771316528, 0.0016094966558739543, 0.6772686243057251, 0.054820943623781204, -0.16614969074726105, 0.1915825605392456, 0.31969985365867615, 0.09024917334318161, -0.1564745455980301, -0.22890233993530273, -0.14931967854499817, -0.1559082567691803, -0.04828697815537453, 0.12368898838758469, -0.11349555850028992, 0.2571306824684143, 0.30266621708869934, -0.0105201480910182, -0.07543958723545074, -0.21175220608711243, -0.2174227237701416, 0.09723050892353058, 0.16856616735458374, 0.18050113320350647, 0.15832823514938354, 0.349576860666275, -0.656531810760498, 0.433146595954895, 0.16532054543495178, 0.03595634549856186, -0.052738405764102936, -0.17800980806350708, 0.8513193130493164, -0.395401269197464, -0.9472795724868774, -0.4030703902244568, -0.07822542637586594, -0.3108322322368622, 0.09314998984336853, -0.01044810563325882, 0.05156772583723068, 0.10215745121240616, 0.14567644894123077, 0.031320828944444656, -0.013937514275312424, 0.050916027277708054, 0.1619548201560974, 0.04829047992825508, -0.5947735905647278, -0.1562207192182541, -0.09252166002988815, -0.021018441766500473, -0.010115641169250011, -0.49788182973861694, -0.294381707906723, 0.17433348298072815, 0.7109827399253845, -0.033161140978336334, -0.18636831641197205, -0.5707226395606995, -0.3434741497039795, -0.3265133798122406, -0.29352039098739624, -0.012092883698642254, 0.4024140536785126, 0.22660548985004425, -0.09085926413536072, -0.567074179649353, -0.09111327677965164, -0.2324134260416031, -0.22419390082359314, 0.052965305745601654, 0.24157895147800446, 0.2396148294210434, 0.19158484041690826, 0.3333393931388855, 0.31422820687294006, -0.399425745010376, -0.3470306396484375, -0.18692216277122498, 0.08893157541751862, -0.18256255984306335, -0.17302697896957397, -0.7960612177848816, -0.21288734674453735, 0.6941350698471069, -0.3099818527698517, 0.4992915987968445, -0.15795886516571045, -0.5536668300628662, -0.15744978189468384, 0.15950733423233032, 0.05374186486005783, 0.48632577061653137, -0.45700034499168396, -0.05767928063869476, -0.3682756721973419, 0.39143452048301697, 0.6490148305892944, -0.7805970907211304, 0.24952900409698486, -0.22787505388259888, -0.7172010540962219, 0.15602944791316986, 0.3417343199253082, 0.09518785029649734, -0.3396376371383667, -0.256588339805603, -0.1905323565006256, -0.09556189179420471, -0.030376214534044266, 0.3167601227760315, -1.0675992965698242, 0.5785238742828369, 0.15339519083499908, -0.535756528377533, 0.4021470248699188, 0.27871260046958923, 0.4763784110546112, -0.6544443368911743, -0.6569800972938538, 0.35974669456481934, -0.06121165677905083, -0.31377795338630676, -0.045413874089717865, -0.17667382955551147, 0.19367684423923492, -0.25133728981018066, -0.22272096574306488, -0.23957137763500214, -0.02358493208885193, -0.6224156022071838, -0.3608713150024414, -0.19952352344989777, -0.28528571128845215, -0.3416747450828552, -0.0982733964920044, 0.2909650504589081, -0.060510359704494476, -0.4036092162132263, 0.03418167307972908, -0.39712023735046387, 0.3199426531791687, -0.08716927468776703, 0.39489981532096863, 0.8566036224365234, 0.29304224252700806, -0.04538027569651604, -0.10786627978086472, 0.038389481604099274, -0.6281328201293945, 0.24953165650367737, -0.11739833652973175, -0.23358365893363953, -0.013828789815306664, -0.042245663702487946, 0.07377757877111435, -0.8311271667480469, 0.5470359325408936, 0.04042486473917961, -0.32854390144348145, 0.10670473426580429, -0.03440507873892784, 0.3712579011917114, -0.42629891633987427, -0.1571885496377945, -0.4433310329914093, 0.2802945375442505, 0.5273561477661133, 0.246149942278862, -0.21330760419368744, -0.3776825964450836, -0.1490214616060257, 0.26460325717926025, 0.5570717453956604, -0.13800311088562012, -0.19772619009017944, 0.12450297176837921, 0.10316425561904907, -0.36988598108291626, -0.14431177079677582, 0.46066853404045105, 0.6142297983169556, -0.012116692028939724, 0.3754647672176361, 0.5842620730400085, -0.2446223795413971, 0.09190330654382706, -0.6492334008216858, -0.3967510759830475, 0.5214414596557617, 0.024637460708618164, -0.16376301646232605, 0.70902419090271, 0.7106493711471558, -0.12077022343873978, -0.611989438533783, 0.16030198335647583, -0.2904687225818634, 0.33555299043655396, -0.2929633855819702, 0.6664665341377258, 0.5717952251434326, 0.7863175868988037, 0.2170795202255249, 0.7636991143226624, -0.12712019681930542, -0.13840344548225403, -0.055160317569971085, -0.7445716261863708, -0.14679284393787384, -0.2875465452671051, 0.9012226462364197, 0.4455350637435913, 0.3712380528450012, -0.0992448702454567, -0.05002998560667038, 0.24932099878787994, -0.021763941273093224, 0.7091282606124878, -0.10177686810493469, -0.052627865225076675, 0.2986111640930176, 0.15866950154304504, -0.10268247127532959, -0.3583563268184662, 0.11112505942583084, 0.11607358604669571, -0.34016671776771545, -0.04613767936825752, -0.276161253452301, 0.4508494734764099, -0.1216500848531723, 0.26410025358200073, -0.03421669825911522, 0.05159404128789902, -0.3842565715312958, -0.20923151075839996, 0.555691659450531, -0.0308589655905962, -0.24648024141788483, -0.12862445414066315, 0.0295172818005085, -0.11840541660785675, -0.33650529384613037, 0.4387517273426056, -0.02487361431121826, -0.16523635387420654, 0.03320464864373207, 0.13780759274959564, -0.05756363645195961, 0.47284549474716187, -0.5025362372398376, -0.5850203633308411, 0.1889694184064865, -0.321239709854126, 0.2712365388870239, 0.09009566903114319, -0.47954636812210083, 0.37180212140083313, 0.36515238881111145, 0.011481737717986107, 0.1521579623222351, -0.1648961305618286, 0.39910975098609924, -0.013725429773330688, 0.26919040083885193, -0.03291153907775879, -0.4212065637111664, 0.06256628781557083, 0.2847205698490143, 0.41819170117378235, -0.2459886074066162, -0.06498987227678299, -0.19662296772003174, 0.4850567877292633, -0.26524409651756287, 0.5608179569244385, -0.2976912260055542, 0.0012379251420497894, -0.5738969445228577, 0.3359167277812958, 0.33271169662475586, 0.3059614896774292, -0.298513799905777, 0.3055071234703064, -0.45766621828079224, 0.0037515682633966208, 0.37861061096191406, -0.2702637016773224, -0.2475559264421463, -0.24015618860721588, -0.47516727447509766, -0.5290349721908569, 0.2875024974346161, -0.022317465394735336, -0.3499888777732849, 0.33358603715896606, 0.1808265894651413, 0.2629351019859314, -0.3220808207988739, 0.3744732737541199, -0.5037471652030945, -0.509040117263794, -0.15178918838500977, 0.3681949973106384, -0.9872725009918213, 0.06745773553848267, 0.596813440322876, 0.09212575852870941, 0.04630686342716217, -0.11775432527065277, -0.11833249777555466, -0.05440666899085045, 0.42944952845573425, -0.0006572168204002082, 0.5650025606155396, 0.5278317928314209, 0.18995137512683868, -0.016324421390891075, -0.6694214344024658, 0.37724730372428894, -0.3879971206188202, -0.47478097677230835, -0.27783581614494324, -0.412578821182251, -0.060660168528556824, -0.0232594795525074, 0.0631113275885582, -0.307270884513855, -0.27151405811309814, -0.39687687158584595 ]
Diabetes is a group of chronic diseases characterized by hyperglycemia. Modern medical care uses a vast array of lifestyle and pharmaceutical interventions aimed at preventing and controlling hyperglycemia. In addition to ensuring the adequate delivery of glucose to the tissues of the body, treatment of diabetes attempts to decrease the likelihood that the tissues of the body are harmed by hyperglycemia. The importance of protecting the body from hyperglycemia cannot be overstated; the direct and indirect effects on the human vascular tree are the major source of morbidity and mortality in both type 1 and type 2 diabetes. Generally, the injurious effects of hyperglycemia are separated into macrovascular complications (coronary artery disease, peripheral arterial disease, and stroke) and microvascular complications (diabetic nephropathy, neuropathy, and retinopathy). It is important for physicians to understand the relationship between diabetes and vascular disease because the prevalence of diabetes continues to increase in the United States, and the clinical armamentarium for primary and secondary prevention of these complications is also expanding. ### Diabetic retinopathy Diabetic retinopathy may be the most common microvascular complication of diabetes. It is responsible for ∼ 10,000 new cases of blindness every year in the United States alone.1 The risk of developing diabetic retinopathy or other microvascular complications of diabetes depends on both the duration and the severity of hyperglycemia. Development of diabetic retinopathy in patients with type 2 diabetes was found to be related to both severity of hyperglycemia and presence of hypertension in the U.K. Prospective Diabetes Study (UKPDS), and most patients with type 1 diabetes develop evidence of retinopathy within 20 years of diagnosis.2,3 Retinopathy may begin to develop as early as 7 years before the diagnosis of diabetes in patients with type 2 diabetes.1 There are several proposed pathological mechanisms by which diabetes may lead …
[ -0.013823224231600761, 0.01604592427611351, -0.019523805007338524, 0.007876109331846237, 0.03449321910738945, -0.016002796590328217, 0.009389782324433327, 0.0265472624450922, -0.01450132206082344, -0.040644340217113495, -0.01648910529911518, 0.005804968997836113, -0.012394108809530735, 0.0233500637114048, 0.01176846120506525, 0.0030423973221331835, -0.00631019938737154, 0.00217621261253953, 0.009226139634847641, -0.0018471372313797474, 0.007461237255483866, -0.006136128678917885, 0.010980214923620224, 0.032310549169778824, 0.01236018631607294, 0.013663062825798988, 0.02804732695221901, -0.028759676963090897, -0.0222857054322958, 0.02076253667473793, -0.012187007814645767, 0.0015489286743104458, 0.010370359756052494, 0.034520506858825684, -0.002377518452703953, 0.020510446280241013, 0.00980712566524744, 0.022086845710873604, -0.020017918199300766, -0.0025970973074436188, 0.022477440536022186, -0.0021794463973492384, 0.0023912449833005667, 0.012231383472681046, -0.009612713940441608, 0.006934600882232189, 0.00508028594776988, -0.0021749334409832954, -0.0012026811018586159, 0.01209290325641632, -0.01686265505850315, -0.007634889334440231, 0.0003137404564768076, 0.002738756826147437, -0.006506392732262611, -0.00586966797709465, 0.020539913326501846, 0.026702892035245895, -0.03636414557695389, 0.0341222807765007, 0.0037689385935664177, -0.011498785577714443, 0.012269734404981136, 0.03263711929321289, -0.003110709600150585, -0.06698495149612427, 0.005247901659458876, 0.023335278034210205, 0.0016925246454775333, -0.004465787205845118, -0.006430399604141712, 0.0026640943251550198, 0.004331446252763271, 0.021325264126062393, -0.004866825882345438, -0.007656584959477186, 0.013044523075222969, 0.04269969463348389, 0.02478453889489174, -0.009887998923659325, -0.02372276969254017, 0.001864806399680674, -0.03443741798400879, 0.037865713238716125, 0.007998770102858543, -0.01626679301261902, -0.019138194620609283, -0.03231407701969147, 0.006598224397748709, 0.019841961562633514, 0.005780850537121296, -0.008695447817444801, -0.015111221000552177, -0.01749555766582489, -0.00902152806520462, -0.0017978372052311897, -0.0026524600107222795, 0.029271164909005165, -0.0013813780387863517, -0.026741378009319305, -0.009429102763533592, -0.004928825423121452, 0.008344640024006367, 0.015634221956133842, -0.003403616603463888, 0.010396741330623627, -0.014464767649769783, 0.007747176103293896, -0.035977985709905624, 0.009999937377870083, 0.009375592693686485, 0.01312702614814043, 0.001535467803478241, -0.0012607824755832553, 0.02636266127228737, 0.029654519632458687, 0.008505973033607006, -0.01846836879849434, 0.006821104325354099, -0.014492345973849297, -0.021876763552427292, 0.005808628164231777, 0.006567067466676235, -0.011322692036628723, 0.0016707655740901828, -0.012628879398107529, 0.029166871681809425, 0.007682005409151316, 0.004874852951616049, -0.012003922834992409, -0.0070490059442818165, 0.006666871253401041, 0.024616824463009834, 0.012400218285620213, -0.012423872947692871, -0.005310041829943657, -0.019070789217948914, 0.009776894934475422, -0.007073097862303257, -0.015584481880068779, -0.000746134202927351, 0.004694577306509018, -0.002051540883257985, 0.0026475803460925817, 0.007693106774240732, -0.0011388170532882214, 0.000630535650998354, 0.006828146521002054, 0.013449426740407944, -0.04540238529443741, 0.0037147076800465584, -0.005167466588318348, 0.0005890182219445705, -0.0072577171958982944, -0.009358668699860573, -0.015651393681764603, -0.004218528047204018, 0.001598426140844822, -0.003052285872399807, 0.011618873104453087, 0.004653221927583218, -0.00807953905314207, 0.026495248079299927, 0.006826404482126236, 0.0007681893184781075, 0.0041924044489860535, 0.02604951336979866, -0.018713748082518578, 0.007180254440754652, 0.0031501061748713255, -0.016139311715960503, 0.0017858073115348816, -0.023101890459656715, 0.01473630964756012, 0.0005397573113441467, 0.0013786668423563242, -0.020365998148918152, 0.00940706580877304, 0.014608418568968773, 0.06612195074558258, -0.010705797001719475, 0.02028493955731392, -0.015040931291878223, 0.009956449270248413, 0.01161583699285984, -0.009121469222009182, -0.012120984494686127, -0.011893697082996368, -0.014289644546806812, -0.002523197326809168, -0.01217163261026144, -0.0021396977826952934, 0.02116492949426174, 0.023096518591046333, -0.01094520278275013, 0.004982462152838707, 0.008328747004270554, -0.003591368440538645, 0.014596403576433659, 0.008907892741262913, -0.007802936714142561, 0.0005758878542110324, 0.036267757415771484, 0.013760693371295929, 0.015747681260108948, 0.0027477957773953676, -0.017282526940107346, 0.002870015799999237, 0.013825299218297005, 0.007915521040558815, 0.03186237812042236, 0.012497490271925926, 0.010176749899983406, 0.003231929149478674, -0.025198284536600113, 0.00014117173850536346, -0.04720735922455788, 0.004747387021780014, -0.015463339164853096, -0.012002047151327133, -0.0003301312681287527, 0.009715084917843342, -0.025427773594856262, 0.0004961166996508837, -0.021415360271930695, -0.026857782155275345, 0.01899752765893936, 0.011587265878915787, -0.005568906664848328, 0.01758590154349804, -0.015596995130181313, -0.01989743299782276, -0.0048954905942082405, -0.01294653955847025, 0.015543155372142792, 0.01285981759428978, 0.007746528834104538, 0.006183122284710407, 0.01532728411257267, -0.011835543438792229, -0.005029001738876104, -0.013868581503629684, -0.001077505643479526, 0.010800028219819069, -0.014897947199642658, 0.010934206657111645, -0.008826244622468948, 0.018103426322340965, 0.006222888827323914, -0.01419910416007042, 0.0034088878892362118, 0.013492485508322716, 0.020885221660137177, -0.004034847021102905, 0.0014491640031337738, -0.007082467898726463, 0.024555854499340057, -0.008957887068390846, 0.02637690305709839, 0.0012017481494694948, 0.0010083813685923815, 0.003971992060542107, 0.004745893646031618, 0.019120967015624046, -0.018376179039478302, 0.020481552928686142, 0.00365855498239398, 0.01904897391796112, -0.0061943079344928265, 0.014172341674566269, 0.005104927346110344, -0.0042902263812720776, 0.0020349430851638317, -0.08139879256486893, -0.015515372157096863, 0.002051679650321603, 0.03904885798692703, 0.0078093814663589, -0.0163066778331995, 0.029750969260931015, -0.010213452391326427, -0.014607947319746017, -0.006025669630616903, 0.013708608224987984, -0.00009462190791964531, -0.009126763790845871, 0.01988382264971733, 0.0020515196956694126, -0.006135419011116028, 0.0045213596895337105, -0.0003427211195230484, -0.0008886129362508655, -0.003008458763360977, -0.014575546607375145, 0.007803597021847963, 0.01783621869981289, -0.0202147476375103, 0.03690582141280174, 0.014843305572867393, 0.0236874520778656, -0.004798875190317631, -0.03457259386777878, 0.00915471836924553, 0.032712098211050034, -0.003894576570019126, 0.025668257847428322, -0.011977322399616241, -0.015522278845310211, -0.009285112842917442, -0.01111950259655714, -0.0005956065724603832, -0.0009327318985015154, -0.0026885652914643288, 0.001996265724301338, 0.011656342074275017, -0.005257607903331518, -0.006931821350008249, 0.019414152950048447, 0.0019395612180233002, 0.029067493975162506, 0.02039637789130211, 0.010336006991565228, 0.003447336610406637, 0.01661684736609459, 0.000993699417449534, 0.029357105493545532, 0.006609483156353235, -0.011198041960597038, -0.001738362479954958, 0.013112528249621391, -0.020510347560048103, -0.014348982833325863, -0.0011688796803355217, 0.0034598184283822775, 0.0040324074216187, 0.007544952444732189, -0.011814204044640064, -0.022237654775381088, -0.012156599201261997, 0.017600294202566147, 0.002613847143948078, -0.007739442400634289, -0.0061223432421684265, -0.009333617985248566, -0.01654347963631153, 0.007580754347145557, -0.008302235044538975, 0.03435160964727402, -0.003975328058004379, -0.011637572199106216, 0.002217027358710766, 0.00691866222769022, 0.003198939375579357, -0.025165293365716934, 0.03029855340719223, -0.008045803755521774, -0.001567285624332726, 0.0005108565092086792, -0.019530780613422394, 0.0023941921535879374, 0.002905498491600156, 0.007872549816966057, -0.011389542371034622, -0.030566878616809845, 0.02600177749991417, -0.026806039735674858, 0.010322661139070988, 0.012905173003673553, -0.025447577238082886, 0.022566702216863632, 0.008665397763252258, 0.004524173215031624, 0.01033199392259121, -0.036552101373672485, 0.008231773972511292, -0.02061319723725319, -0.015181136317551136, 0.021903162822127342, 0.01896173134446144, 0.016745399683713913, 0.0056173293851315975, 0.0046632601879537106, -0.015084870159626007, 0.002980214776471257, 0.004095199052244425, -0.00850115530192852, 0.017572952434420586, 0.011599252000451088, 0.03671973943710327, 0.00537168188020587, 0.008276555687189102, 0.07162588834762573, 0.000534870196133852, 0.00500656059011817, -0.017266973853111267, 0.005402563139796257, -0.030842173844575882, -0.01023499108850956, 0.03822789713740349, 0.007352210581302643, -0.008839117363095284, 0.014232270419597626, 0.010823234915733337, 0.024960149079561234, -0.012225789949297905, -0.00008193147368729115, 0.0045799631625413895, -0.023676365613937378, 0.0038633139338344336, -0.00639315927401185, -0.020890744403004646, 0.01601509377360344, -0.0015403889119625092, -0.009431736543774605, 0.020243491977453232, -0.0007912544533610344, -0.04399195313453674, -0.00421166094020009, -0.00936879776418209, 0.011206268332898617, 0.006108505185693502, -0.0027934182435274124, 0.02723749913275242, -0.0014308660756796598, 0.012339457869529724, 0.0014571649953722954, 0.016171179711818695, 0.022855889052152634, -0.015633752569556236, 0.014197714626789093, -0.0034471796825528145, -0.0025725592859089375, -0.013068527914583683, 0.026205677539110184, 0.028676439076662064, 0.006495059467852116, 0.030296748504042625, 0.0044062091037631035, -0.005970444064587355, 0.003880072385072708, 0.017816578969359398, -0.003606601618230343, -0.0021706880070269108, 0.007568858098238707, 0.022074557840824127, -0.013728316873311996, -0.019272388890385628, -0.01209359522908926, -0.018728092312812805, 0.0033056680113077164, -0.005119064822793007, 0.00027569360099732876, -0.0302724689245224, 0.018257804214954376, 0.01444386225193739, 0.011833934113383293, 0.010863598436117172, 0.019507529214024544, 0.004807622171938419, -0.003954160958528519, -0.005808236077427864, 0.010057772509753704, 0.01095808669924736, -0.0015291967429220676, -0.008013486862182617, -0.02762106992304325, 0.009500112384557724, 0.027132606133818626, -0.010453999042510986, 0.03151026740670204, -0.006134144030511379, -0.01975031942129135, 0.009164059534668922, 0.030969375744462013, -0.02166770026087761, 0.02081831358373165, 0.04763998091220856, -0.028320394456386566, -0.07459310442209244, -0.003141731023788452, 0.0007135509513318539, -0.008740276098251343, 0.004705762956291437, -0.027308480814099312, -0.003191198455169797, -0.014409873634576797, -0.005942842457443476, -0.0017110516782850027, -0.02162993513047695, -0.014686968177556992, -0.02016759291291237, -0.0016092180740088224, 0.013010467402637005, 0.016827944666147232, -0.021309833973646164, -0.0019335999386385083, -0.013192206621170044, 0.01592521369457245, 0.0007744067115709186, -0.0159517303109169, -0.042854826897382736, 0.006491812411695719, -0.006546943448483944, -0.08073637634515762, 0.0015134091954678297, 0.005583807826042175, -0.02237044647336006, -0.004297675099223852, -0.006420432589948177, 0.0021323836408555508, -0.020490560680627823, 0.018591435626149178, -0.017586154863238335, -0.0200718492269516, 0.005823105573654175, 0.005016337148845196, -0.008591579273343086, -0.0026143405120819807, -0.010264288634061813, 0.008752375841140747, 0.04239208251237869, -0.01731000281870365, -0.02950216457247734, -0.03752339631319046, 0.002756440080702305, -0.01680288091301918, 0.015630992129445076, -0.014281844720244408, -0.0062108393758535385, 0.0023015025071799755, 0.010530823841691017, 0.01646348461508751, 0.022087693214416504, 0.008218267001211643, -0.005363951437175274, 0.00014792499132454395, -0.0157755259424448, 0.0003205897519364953, -0.009511586278676987, 0.03514159470796585, -0.00691707618534565, 0.022869139909744263, -0.01988895982503891, -0.0033693071454763412, -0.0035067228600382805, -0.03978881612420082, 0.003174522425979376, 0.00981423445045948, 0.01807132363319397, 0.005618035793304443, -0.003937408793717623, 0.0022112249862402678, -0.01652328483760357, 0.0009614867740310729, -0.034157052636146545, 0.019196083769202232, -0.0471116341650486, -0.02584719844162464, 0.003928941208869219, -0.005657787900418043, 0.019728148356080055, -0.00676746154204011, 0.010613447055220604, 0.006504050921648741, -0.01116929017007351, 0.012778926640748978, 0.07099360227584839, -0.009752877987921238, 0.0075148530304431915, -0.01216922514140606, 0.0013215120416134596, 0.0027755163609981537, -0.011622343212366104, -0.012069293297827244, -0.01118922233581543, -0.006746246479451656, -0.012709097005426884, -0.0024547940120100975, -0.014207698404788971, 0.009501274675130844, -0.005264203995466232, -0.00009005656465888023, 0.014301079325377941, -0.0238274484872818, -0.0064635369926691055, -0.008224669843912125, -0.008747655898332596, 0.018213441595435143, -0.02655920758843422, 0.010393080301582813, 0.017600540071725845, -0.013933749869465828, 0.006301259621977806, 0.001583960372954607, -0.005250878166407347, 0.004193750210106373, 0.006274792831391096, -0.014322853647172451, 0.000984974205493927, 0.024748019874095917, 0.02718326635658741, -0.005291385110467672, -0.004297788720577955, -0.011434998363256454, -0.01969786360859871, 0.010886549949645996, 0.017696861177682877, 0.002602469176054001, -0.0019235213985666633, -0.02562187984585762, 0.023543234914541245, 0.020431291311979294, 0.010166718624532223, -0.010970775038003922, -0.006817921996116638, 0.013596692122519016, -0.0008873662445694208, -0.0018309701699763536, -0.004404855892062187, -0.006666134111583233, 0.012505186721682549, 0.021518127992749214, -0.033599093556404114, 0.010305413044989109, -0.013406115584075451, -0.025431977584958076, -0.003367077559232712, -0.022456645965576172, 0.006008844822645187, -0.019519440829753876, 0.003216799348592758, 0.017318090423941612, 0.020620964467525482, -0.003549228422343731, -0.010251658968627453, 0.014326738193631172, 0.015852810814976692, 0.00882006622850895, 0.005295389331877232, 0.006138158496469259, 0.01691618748009205, -0.01886182650923729, 0.020639894530177116, -0.031753573566675186, 0.01713385060429573, 0.006097797770053148, 0.0019032545387744904, -0.021617792546749115, 0.025256244465708733, 0.0025726757012307644, -0.027530528604984283, -0.019337961450219154, -0.0025680530816316605, -0.0019600307568907738, -0.016193155199289322, 0.0044713132083415985, -0.024062618613243103, -0.011037025600671768, 0.0006170221022330225, -0.01120208203792572, 0.007832263596355915, 0.035966578871011734, -0.01069826539605856, 0.003894767025485635, -0.00363724771887064, 0.006062665022909641, 0.0211811326444149, -0.01471799798309803, 0.011238460429012775, -0.0013722173171117902, -0.015076888725161552, -0.00920628011226654, 0.011035511270165443, -0.008672337047755718, -0.006851956248283386, -0.001976318657398224, -0.023256847634911537, -0.011240161955356598, 0.017887679859995842, 0.03423849120736122, 0.006358794867992401, -0.008134355768561363, -0.012650053948163986, 0.013780087232589722, -0.0024963561445474625, -0.014110781252384186, 0.0014705844223499298, 0.010404776781797409, -0.018031086772680283, 0.015533058904111385, 0.011916454881429672, -0.004445121623575687, -0.012480671517550945, -0.0024321237578988075, 0.006243727635592222, 0.000730365514755249, 0.008061864413321018, -0.010130224749445915, 0.00786910206079483, 0.035531818866729736, 0.024039065465331078, 0.008745534345507622, -0.03336840867996216, 0.006584512069821358, -0.0396500788629055, -0.00802721455693245, 0.025050291791558266, 0.005425362382084131, -0.0034604135435074568, -0.011760321445763111, 0.008512549102306366, 0.0032990016043186188, 0.0005114604718983173, 0.014983396045863628, 0.018282905220985413, 0.012141317129135132, 0.010713701136410236, 0.006207800004631281, -0.021045036613941193, -0.00914084818214178, -0.021888375282287598, 0.022281065583229065, 0.0010080705396831036, 0.02577744610607624, -0.014688963070511818, -0.0008417179342359304, -0.0021846070885658264, -0.0052788336761295795, -0.0022625611163675785, 0.006103833205997944, 0.006069997791200876, 0.022300608456134796, 0.0019060000777244568, -0.012345499359071255, -0.01729877106845379, -0.0203913152217865, 0.022392679005861282, 0.005856337491422892, -0.01465122401714325, 0.008785786107182503, -0.013553042896091938, -0.019065985456109047, -0.022276272997260094, -0.023258686065673828, -0.0001955148472916335, 0.013942811638116837, -0.0011906452709808946, -0.03130742534995079, 0.003080346854403615, -0.0032941149547696114, -0.011339165270328522, 0.003132534446194768, -0.013263950124382973, 0.00020212377421557903, 0.006475204601883888, -0.029437435790896416, 0.003066815435886383, -0.010100512765347958, 0.004053173121064901, 0.0056435177102684975, -0.0012471986701712012, -0.013162040151655674, 0.0022311476059257984, 0.009786705486476421, 0.014515958726406097, 0.010330714285373688, 0.01756703108549118, -0.024091031402349472 ]
[ 0.11857037246227264, 0.427249938249588, 0.04355951398611069, 0.15923942625522614, 0.20382040739059448, 0.1755785197019577, 0.5410919785499573, -0.06877917796373367, 0.016971953213214874, -0.8190670013427734, 0.06682908535003662, 0.6843273639678955, -0.8238983750343323, 0.21758905053138733, -0.08150863647460938, 0.46822041273117065, 0.3147633969783783, 0.805793046951294, -0.03345846012234688, 0.1328224390745163, -0.48861926794052124, -0.32661840319633484, 0.3566119372844696, 0.241904616355896, -0.08612429350614548, 0.012242289260029793, 0.1865035891532898, 0.6454989910125732, -0.23213154077529907, -0.331903338432312, 0.2314789742231369, 0.2752590775489807, -0.15464837849140167, 0.025791125372052193, -0.05228644609451294, 0.3442823588848114, -0.26064521074295044, -0.5551608800888062, 0.21331068873405457, 0.004189550876617432, -0.007906126789748669, 0.5316525101661682, -0.2547331154346466, 0.5987087488174438, 0.20488372445106506, -0.012039517052471638, -1.4474281072616577, 0.5069969892501831, 0.07174451649188995, 0.028648165985941887, -0.07711969316005707, 0.029517030343413353, 0.46149176359176636, 0.35782578587532043, 0.44923195242881775, 0.42359989881515503, -0.6097665429115295, -0.03099210187792778, 0.05308040231466293, -0.19655156135559082, 0.14188367128372192, -0.2969743311405182, -0.29086029529571533, 0.09464474022388458, -0.48317912220954895, 0.17392762005329132, -0.340376615524292, 0.04760473594069481, -0.3370341956615448, 0.06407860666513443, 0.22910581529140472, -0.45609214901924133, -0.3212670385837555, 0.509450376033783, -0.09167014062404633, -0.3286416530609131, -0.04256628081202507, -0.512408435344696, 0.22436265647411346, 0.09045291692018509, 0.1736934781074524, 0.16705410182476044, 0.04939786717295647, 0.32427528500556946, 0.1285107284784317, 0.2077997624874115, 0.23852026462554932, 1.0030386447906494, -0.19265928864479065, 0.10740220546722412, 0.14095497131347656, 0.23266936838626862, 0.3729389011859894, -0.1640266478061676, 0.05327635258436203, 0.13354086875915527, 0.8204682469367981, -0.14782781898975372, 0.2497294694185257, 0.08967775851488113, 0.13834300637245178, -0.5502054691314697, -0.055632807314395905, -0.06743193417787552, -0.09325346350669861, -0.13946571946144104, 0.01740310713648796, -0.5783393383026123, 0.03460230305790901, 0.31104928255081177, -0.6723446249961853, 0.2593608796596527, -0.3984433710575104, -0.24819207191467285, -0.28122052550315857, 0.5111117959022522, -0.3535805344581604, -0.38847091794013977, -0.4171915054321289, 0.03536878526210785, -0.10213834047317505, 0.018681900575757027, -0.06255204975605011, 0.14125576615333557, -0.3418092131614685, 0.1635371446609497, 0.10052301734685898, 0.19214709103107452, 0.20077210664749146, 0.3507601022720337, 0.20322410762310028, 0.6026402115821838, -0.2191249132156372, -0.8067591190338135, 0.15535227954387665, -0.22381837666034698, 0.1288457065820694, -0.1737731397151947, 0.12797844409942627, 0.08841820061206818, 0.15315814316272736, -0.7729243040084839, -0.14610059559345245, -0.1674785166978836, -0.2784597873687744, -0.39729389548301697, -0.2837207317352295, 0.09935873746871948, 0.17928144335746765, -0.1239987313747406, 0.18662148714065552, 0.006655542179942131, -0.35385870933532715, 0.18519142270088196, -0.2519054412841797, 0.2600652277469635, -0.1759078949689865, -0.2528226673603058, -0.4054745137691498, -0.13005872070789337, 0.15865589678287506, -0.3501652777194977, -0.6373233795166016, -0.2189607471227646, 0.3308776319026947, -0.15324892103672028, 0.23813462257385254, 0.44021075963974, 0.19669145345687866, 0.29635825753211975, -0.44022631645202637, -0.40431585907936096, -0.12939682602882385, -0.6073436141014099, 0.18189015984535217, 0.2935008704662323, 0.4254235625267029, 0.17718356847763062, 0.19109275937080383, 0.07628361880779266, -0.6098055839538574, 0.4794638156890869, 0.14050164818763733, -0.1844136267900467, 0.2678493559360504, -0.1420052945613861, 0.4066287875175476, -0.38275760412216187, 0.21795549988746643, -0.37714511156082153, -0.5390025973320007, -0.44282498955726624, 0.7360536456108093, -0.7082184553146362, 1.3410429954528809, -0.4838128685951233, -0.3943935036659241, 0.4252244234085083, -0.16733931005001068, -0.47473621368408203, -0.04507629945874214, 0.005008261185139418, 0.13541017472743988, -0.5304691195487976, -1.0431655645370483, -0.0006673356983810663, -0.13110536336898804, -0.33043158054351807, 0.2923002541065216, -0.14741209149360657, 0.8243268132209778, -1.0054948329925537, -0.4273937940597534, -0.4404391348361969, 0.12795785069465637, -0.30887869000434875, -0.4337465763092041, 0.17055460810661316, -0.38460221886634827, -0.0372517928481102, 0.5483530163764954, -0.49697497487068176, 0.45712989568710327, 0.8690761923789978, 0.5055267214775085, 0.5115458369255066, 0.7695683836936951, 0.30651330947875977, 0.9552680850028992, -0.3531010150909424, 0.9118643403053284, -0.2223305106163025, 0.5297552347183228, -0.6510756015777588, -0.3122961223125458, 0.4175010323524475, 0.031202470883727074, -0.21634331345558167, 0.04558801278471947, -0.5357511639595032, -0.10939536243677139, 0.39302533864974976, -0.60938560962677, -0.13279888033866882, 0.20736147463321686, -0.5672433376312256, -0.7623722553253174, 0.4013042151927948, -0.951354444026947, -0.6433684825897217, 0.10429462790489197, 0.7203536629676819, 0.23134808242321014, -0.3957917392253876, 0.2703714966773987, -0.38802918791770935, -0.23821397125720978, 0.3048551380634308, 0.1682864874601364, -0.3455435335636139, -0.5927709937095642, 0.17034058272838593, 0.15248188376426697, 0.2671365439891815, -0.21835343539714813, 0.170994371175766, -0.4989621043205261, -0.6382028460502625, 0.11226349323987961, 0.5777819752693176, 0.9619919657707214, 0.20558284223079681, -0.7495086193084717, -0.03158356994390488, -0.11237479001283646, -0.4282504618167877, 0.4086863398551941, 0.9954870343208313, -0.7079790234565735, 0.036988187581300735, -0.1703791469335556, 0.6809225082397461, 0.5002956390380859, -0.31286439299583435, -0.8252534866333008, -0.1813453584909439, -0.11018376797437668, -0.3900631070137024, -0.6878417730331421, 0.34790921211242676, -0.4794093370437622, 0.7207575440406799, -0.47443681955337524, -0.3978101313114166, 0.5443159341812134, 0.13530828058719635, -0.1083291620016098, 0.2745564579963684, 0.6761844158172607, -0.3115960955619812, 0.30571699142456055, 0.1372535526752472, -0.15602423250675201, -0.07858138531446457, -0.44700509309768677, -0.07591236382722855, -0.43259477615356445, 0.2546548545360565, -5.687801837921143, -0.3916760981082916, -0.2702213227748871, -0.4941524565219879, -0.1582327038049698, -0.4281730055809021, 1.0448843240737915, 0.28595641255378723, 0.05703532323241234, 0.4661184549331665, 0.6817847490310669, 0.591955304145813, 0.40930718183517456, -0.35606247186660767, -0.21332132816314697, 0.0986001119017601, 0.4969000518321991, -0.4677852690219879, 0.07034476101398468, 0.038783300668001175, 0.6043311357498169, -0.26473331451416016, 0.04754457250237465, 0.8706147074699402, -0.4327077269554138, 0.08398434519767761, -0.8872662782669067, 0.7295776009559631, -0.2198522835969925, -0.16251014173030853, 0.21277423202991486, -0.4844580888748169, 0.13361643254756927, -0.686262309551239, 0.45031580328941345, 0.2181781530380249, -0.31836816668510437, 0.05572327971458435, -0.4434491693973541, -0.2673182487487793, 0.09871078282594681, -0.03159826621413231, -0.18367516994476318, 0.09013712406158447, 0.5425033569335938, 0.06389161199331284, -0.01057017408311367, 0.15760521590709686, -0.5631888508796692, 1.0013056993484497, 0.12178926914930344, -0.20075161755084991, 0.30711525678634644, 0.38529670238494873, 0.47747403383255005, -0.08993685990571976, 0.1317525953054428, -0.355530709028244, -0.22061961889266968, 0.07116848230361938, -0.5898212194442749, -0.10476434975862503, -0.38835030794143677, -0.34665578603744507, -0.018986904993653297, 0.44943106174468994, -0.5203053951263428, -0.7511377334594727, 0.1652447134256363, -0.03701472282409668, -0.5550776720046997, 0.8148004412651062, 0.20733857154846191, -0.6772621273994446, 0.19649638235569, -0.05556759238243103, 0.30360132455825806, 0.3237876296043396, 0.09572460502386093, -0.5816212892532349, -0.3021875023841858, -0.08691827952861786, -0.16587208211421967, 0.2303454726934433, 0.749411404132843, -0.5138126015663147, -0.7034388184547424, -0.34342294931411743, -0.02441900223493576, 0.20781977474689484, 0.8066964149475098, -0.5001340508460999, 0.15125107765197754, 0.2165258526802063, -0.017215542495250702, 0.7340205311775208, 0.07414717227220535, 0.45910072326660156, -0.00456878961995244, -0.27442631125450134, 0.9603381156921387, 0.006306199356913567, -0.04055362194776535, -0.7042939066886902, 0.09584064036607742, -0.1486443430185318, -0.4114295542240143, 0.17465181648731232, 0.6583927273750305, -0.9853222966194153, -0.04885672777891159, 0.21932481229305267, -0.5644964575767517, -0.8114109635353088, 0.5359869599342346, -0.5433865189552307, -0.08300106972455978, 0.19559630751609802, 0.8358506560325623, -0.035802148282527924, -0.0058411541394889355, 0.704502522945404, 0.16429099440574646, 0.003925621043890715, -0.13578329980373383, 0.09963317960500717, 0.13892433047294617, 0.5781856775283813, -0.23191681504249573, 0.1999489963054657, 0.3238050937652588, 0.47620901465415955, -0.24030032753944397, 0.5027028918266296, -0.18445910513401031, -0.09340406954288483, 0.1280069500207901, 0.4659171402454376, -0.10021264851093292, -0.7744070291519165, 0.2522967755794525, -0.13079683482646942, -0.5420999526977539, -0.2524056136608124, 0.38771724700927734, 0.222350612282753, -0.3212824761867523, 0.288914293050766, 0.05595369637012482, 0.35073310136795044, 0.3427767753601074, 0.39483150839805603, -0.18487423658370972, 0.2451017200946808, -0.42746973037719727, 0.5304233431816101, 0.22560660541057587, 0.38095366954803467, 0.3295449912548065, -0.7338244915008545, 0.4777112603187561, -0.068577341735363, -1.0348330736160278, -0.2746681869029999, -0.38172128796577454, 0.3944963216781616, -0.08542941510677338, -0.5535107254981995, -0.30777469277381897, 0.3019794523715973, -0.08669257909059525, -0.3336022198200226, -0.44557008147239685, -0.262984037399292, 0.3008217215538025, -0.34255221486091614, -0.8297103643417358, 0.4022834002971649, -0.09457236528396606, -0.08325394988059998, 0.35498282313346863, -0.7652332186698914, -0.08343084901571274, 0.16254402697086334, 0.574057936668396, -0.16953980922698975, 0.4565199613571167, -0.33119136095046997, -0.3306724727153778, -0.42240071296691895, 0.6578612923622131, 0.02189432643353939, 0.496379017829895, -0.5529823303222656, 0.27308371663093567, -0.27773135900497437, -0.10450483113527298, 0.6686819195747375, -0.02197575755417347, -0.021716248244047165, -0.13451474905014038, 0.5605463981628418, -0.6593732833862305, 0.23519518971443176, 0.5859860777854919, -0.2951144278049469, -0.3085695207118988, -0.009348500519990921, -0.4351985454559326, 0.09186036139726639, -0.4763503074645996, -0.31411075592041016, 0.3895077705383301, 0.554480254650116, -0.44763851165771484, 0.005850482732057571, 0.2447005659341812, 0.03991881012916565, -0.19714674353599548, -0.1720517873764038, 0.6993707418441772, -0.054643385112285614, -0.33582985401153564, -0.1575888842344284, 0.10310971736907959, 0.08305306732654572, 0.5563309192657471, -0.4788518249988556, 0.21511152386665344, 0.3685576021671295, -0.5767536759376526, -0.2849246859550476, 0.08362911641597748, -0.595514714717865, 0.04605318605899811, -0.10437287390232086, 0.05777008458971977, 0.7252984046936035, 0.11536683142185211, 0.3841414749622345, 0.10483832657337189, 0.7024315595626831, -0.1108216792345047, -0.31657737493515015, 0.4073353111743927, 0.39872586727142334, 0.32968223094940186, -0.6566136479377747, -0.4934673607349396, 0.23378241062164307, 0.28086572885513306, 0.39928025007247925, 0.07442040741443634, 0.08469852060079575, 0.4018024802207947, 0.11971959471702576, 0.17303286492824554, -0.2120647132396698, 0.1838272511959076, 0.22919610142707825, 0.10468164831399918, -0.18351151049137115, -0.11250147968530655, -0.061246588826179504, 0.518608808517456, -0.09895072132349014, -0.3802635073661804, -0.685384213924408, 0.5220522284507751, -0.5921981930732727, 0.5155563354492188, -0.20423200726509094, 0.38582807779312134, 0.32699114084243774, -0.1654634326696396, 0.5347860455513, -0.4718939960002899, -0.4176599383354187, -0.5133312344551086, 0.06129775941371918, -0.14084847271442413, -0.6664714813232422, 0.23587371408939362, -0.22586709260940552, 0.6419209241867065, -0.7451193332672119, 0.2865707278251648, -0.4277711510658264, -0.21583789587020874, -0.25184157490730286, -0.2948276102542877, 0.027901021763682365, -0.6298462152481079, -0.3272400498390198, 0.07620535045862198, 0.30600231885910034, 0.17087815701961517, 0.3287431001663208, -0.3778361678123474, -0.4062228798866272, -0.20701727271080017, 0.4688934087753296, 0.11226985603570938, -0.5368778109550476, 0.18191255629062653, 0.3282190263271332, -0.022620709612965584, -0.36514002084732056, -0.4107040762901306, -0.08613942563533783, 0.32721397280693054, -0.06660586595535278, 0.3093055784702301, 0.6678498983383179, 0.04537699371576309, 0.1613674908876419, -0.391669899225235, 0.1590803861618042, 0.14742454886436462, 0.0341578908264637, 0.35552316904067993, 0.4114029109477997, 0.6896936297416687, -0.17907041311264038, -0.06922262907028198, 0.7354767322540283, -0.06013142690062523, 0.37762799859046936, -0.12715671956539154, 0.7247647643089294, 0.6063471436500549, 0.04617408663034439, -0.0573589950799942, 0.47748756408691406, 0.4472624957561493, 0.5642277002334595, 0.43403175473213196, -0.8784720301628113, -0.7569338083267212, 0.02937529981136322, 0.8358792066574097, -0.15037870407104492, -0.08761748671531677, 0.16574765741825104, 0.07416913658380508, 0.5797497630119324, -0.046262748539447784, 0.010328847914934158, 0.004180941730737686, -0.5392530560493469, 0.7680388689041138, -0.5364418029785156, -0.2099926918745041, 0.11804268509149551, -0.4956745505332947, 0.06889333575963974, 0.31791916489601135, -1.0491888523101807, -0.397277295589447, 0.31867516040802, -0.08713044226169586, -0.4332147240638733, 0.001012143911793828, 0.12120550870895386, 0.22487026453018188, 0.1553819477558136, 0.6854711771011353, -0.6694895625114441, 0.7472133636474609, 0.127163827419281, -0.6380481719970703, 0.09516966342926025, -0.3039528429508209, 0.08378180861473083, 0.44534826278686523, -0.29290512204170227, 0.16996504366397858, 0.3769568204879761, 0.49284374713897705, 0.15841859579086304, -0.359454870223999, 0.30944186449050903, -0.47179102897644043, -0.7679686546325684, -0.05928322672843933, -0.08651670068502426, -0.17591190338134766, -0.2320905476808548, -0.03336789458990097, 0.055281881242990494, 0.20249232649803162, -0.3361288011074066, 0.21530203521251678, -0.06260460615158081, 0.31297069787979126, -0.17146115005016327, 0.12405868619680405, 0.43464720249176025, 0.13112518191337585, 0.2296033352613449, -0.32289984822273254, 0.08572573959827423, -0.0760466605424881, 0.21352353692054749, -0.7628005743026733, 0.7389570474624634, -0.1357649564743042, 0.013740425929427147, -0.5876922011375427, 0.2080269157886505, 0.5458872318267822, 0.40390849113464355, 0.22225533425807953, -0.38288888335227966, 0.5264915823936462, 0.10795816034078598, 0.0849374383687973, -0.7010684013366699, -0.7197097539901733, -0.7604709267616272, 0.217514768242836, -0.8123984336853027, 0.6985390186309814, -0.2605116665363312, -0.3254724442958832, -0.37967851758003235, 0.2886434495449066, 0.3411251902580261, -0.14679773151874542, 0.5027807950973511, -0.2518480718135834, 0.543891966342926, -0.7740084528923035, -0.19468143582344055, -0.3025815188884735, -0.1503608375787735, 0.23354431986808777, 0.14952537417411804, 0.04119551554322243, 0.0573338121175766, 0.09474536031484604, -0.15128816664218903, 0.3153495192527771, 0.517508864402771, 0.3750944137573242, 0.28573110699653625, 0.091947041451931, -0.33230510354042053, -0.7956900596618652, 0.3182234466075897, -0.378767728805542, -0.5404943823814392, -0.24412834644317627, 0.09331002086400986, 0.2625814378261566, -0.2563389241695404, 0.017687993124127388, -0.8570030331611633, -0.5698842406272888, 0.05745689570903778 ]
BACKGROUND The role of the diffusible messenger nitric oxide (NO) in the regulation of pain transmission is still a debate of matter, pro-nociceptive and/or anti-nociceptive. S-Nitrosylation, the reversible post-translational modification of selective cysteine residues in proteins, has emerged as an important mechanism by which NO acts as a signaling molecule. The occurrence of S-nitrosylation in the spinal cord and its targets that may modulate pain transmission remain unclarified. The "biotin-switch" method and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry were employed for identifying S-nitrosylated proteins. RESULTS Here we show that actin was a major protein S-nitrosylated in the spinal cord by the NO donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP). Interestingly, actin was S-nitrosylated, more in the S2 fraction than in the P2 fraction of the spinal homogenate. Treatment of PC12 cells with SNAP caused rapid S-nitrosylation of actin and inhibited dopamine release from the cells. Just like cytochalasin B, which depolymerizes actin, SNAP decreased the amount of filamentous actin cytoskeleton just beneath the membrane. The inhibition of dopamine release was not attenuated by inhibitors of soluble guanylyl cyclase and cGMP-dependent protein kinase. CONCLUSION The present study demonstrates that actin is a major S-nitrosylated protein in the spinal cord and suggests that NO directly regulates neurotransmitter release by S-nitrosylation in addition to the well-known phosphorylation by cGMP-dependent protein kinase.
[ 0.001611532410606742, -0.0020841541700065136, -0.019305873662233353, 0.013995623216032982, -0.013230782933533192, -0.008412418887019157, 0.01010562852025032, -0.0007002996280789375, -0.007858862169086933, -0.011573387309908867, -0.011550163850188255, 0.0053081391379237175, -0.01537722535431385, 0.026537317782640457, 0.013262619264423847, 0.006089485250413418, -0.016825251281261444, 0.02506440132856369, 0.009973498061299324, 0.01186432782560587, -0.015568472445011139, -0.01837276667356491, 0.00868703331798315, -0.019684521481394768, 0.03158291429281235, 0.014909854158759117, -0.009460782632231712, 0.013659344986081123, -0.007523560896515846, 0.03680633381009102, -0.03369847685098648, -0.000582557637244463, -0.008633595891296864, 0.018108947202563286, -0.006186565384268761, -0.012062136083841324, -0.0038605034351348877, 0.019832804799079895, 0.03158413618803024, -0.006198883522301912, 0.006349322386085987, -0.01572667434811592, 0.011873988434672356, 0.0009043801110237837, -0.006492189131677151, -0.016645193099975586, 0.0043032849207520485, 0.009625403210520744, 0.0021471886429935694, 0.005252100061625242, 0.004854477476328611, -0.012948756106197834, -0.004690974485129118, 0.026121072471141815, -0.005391450598835945, 0.007344298530369997, 0.01610380783677101, 0.002892071846872568, -0.04147957265377045, -0.03222095966339111, 0.00865665078163147, 0.0352240651845932, -0.005609000101685524, -0.006221902556717396, 0.023753143846988678, -0.06705032289028168, 0.05384504795074463, 0.010321039706468582, -0.005430674180388451, 0.024629708379507065, -0.0032905517145991325, 0.01529601775109768, -0.01690799929201603, -0.03286105394363403, -0.00824965350329876, -0.024151761084794998, -0.004822168964892626, 0.006472636945545673, -0.014628209173679352, 0.020291902124881744, 0.001988467527553439, -0.004288345575332642, -0.026914823800325394, 0.009341578930616379, 0.004775918088853359, -0.026263296604156494, -0.025601910427212715, -0.0063968924805521965, 0.00019963644444942474, -0.012622850947082043, 0.029856320470571518, -0.021675879135727882, -0.03416777029633522, 0.01646874099969864, 0.01794608309864998, 0.004773416090756655, 0.009748956188559532, 0.008672806434333324, 0.028024259954690933, -0.024865416809916496, -0.009816018864512444, 0.026249520480632782, 0.01615213230252266, 0.020557072013616562, 0.03164299950003624, 0.00804564543068409, 0.00985284149646759, 0.013956483453512192, -0.011621757410466671, 0.008443048223853111, 0.005369417369365692, 0.009635994210839272, -0.0001302408054471016, 0.0016768104396760464, 0.053580768406391144, 0.014498749747872353, -0.026612985879182816, -0.022767173126339912, 0.008538056164979935, 0.016611430794000626, 0.01980007067322731, -0.006450323853641748, 0.003895116038620472, 0.017356030642986298, 0.0091115552932024, 0.010695178061723709, -0.014489944092929363, 0.003041873686015606, 0.013110477477312088, -0.0011066655861213803, -0.009404477663338184, 0.0048730699345469475, 0.014567118138074875, -0.013177221640944481, -0.02164546772837639, -0.007826931774616241, 0.0375119224190712, -0.01170085184276104, 0.003091955790296197, 0.00804342795163393, 0.013156058266758919, 0.0030837329104542732, 0.003065448720008135, -0.0011377285700291395, 0.012960321269929409, 0.0038083612453192472, 0.009546061977744102, 0.004312233999371529, 0.000018399208784103394, 0.00708469282835722, -0.019185420125722885, 0.01152398157864809, -0.007492051459848881, -0.01722978614270687, 0.019654322415590286, 0.006834451109170914, -0.036122411489486694, -0.000375951174646616, -0.01581086590886116, 0.008047977462410927, -0.008419271558523178, 0.011214056052267551, 0.0237139742821455, 0.0073061008006334305, -0.012675131671130657, -0.008149513974785805, 0.016300395131111145, -0.0008233452681452036, -0.01706741563975811, 0.011852918192744255, 0.005380414426326752, 0.02597944810986519, 0.010189946740865707, 0.0061866058968007565, -0.0022146061528474092, -0.005106758326292038, 0.026252828538417816, 0.006436402443796396, -0.016590585932135582, 0.06687707453966141, 0.03035343810915947, -0.009878435172140598, -0.006370178423821926, 0.029066424816846848, 0.0145088080316782, -0.011293278075754642, -0.0022981073707342148, 0.003164147725328803, 0.005332308821380138, 0.03745638206601143, 0.020596904680132866, -0.014096773229539394, -0.024945927783846855, 0.002549119293689728, -0.022678997367620468, 0.0024907654151320457, 0.023208653554320335, 0.006471594795584679, -0.0013154915068298578, 0.01565553992986679, -0.00025994889438152313, -0.01683102175593376, 0.033754363656044006, -0.014702723361551762, -0.009503409266471863, 0.005861499812453985, 0.006053348071873188, -0.02953815646469593, -0.005502332933247089, 0.0016166646964848042, 0.02269105613231659, -0.032110974192619324, 0.013290774077177048, -0.004995476920157671, -0.001146362628787756, 0.0023450409062206745, 0.020610526204109192, 0.029802734032273293, -0.007321931887418032, -0.010582037270069122, -0.0017143982695415616, 0.01911502331495285, 0.0047190431505441666, 0.0032187807373702526, 0.0032378523610532284, 0.0027911365032196045, 0.00806176196783781, 0.0111727025359869, -0.008761163800954819, 0.016742970794439316, -0.007101544179022312, -0.0007999292574822903, -0.010916359722614288, 0.01711658574640751, 0.06626744568347931, -0.03117094561457634, 0.011150607839226723, -0.0031278568785637617, 0.016028227284550667, -0.011633176356554031, 0.015038030222058296, 0.007345086894929409, 0.010095326229929924, -0.00882202759385109, 0.010699445381760597, -0.014197535812854767, 0.007435523439198732, 0.02672487124800682, 0.0002740323543548584, 0.023533526808023453, 0.007931765168905258, -0.006030574440956116, -0.0019022012129426003, -0.017007997259497643, -0.006375080905854702, -0.025842055678367615, -0.007503264117985964, -0.020868653431534767, 0.02285340242087841, 0.011058698408305645, -0.006164344027638435, 0.00864163413643837, -0.02353367581963539, 0.0077530015259981155, -0.0101380106061697, 0.029173718765378, -0.02379492297768593, -0.00017652614042162895, -0.028690645471215248, 0.0033400929532945156, 0.007895130664110184, -0.012776220217347145, -0.0007835564902052283, -0.0817292109131813, -0.005394760053604841, -0.01984182372689247, -0.017406385391950607, 0.01008998230099678, -0.004169773776084185, 0.012014626525342464, 0.010624894872307777, -0.01423113327473402, -0.0011141495779156685, 0.014917838387191296, -0.009383287280797958, -0.01041647419333458, -0.010714458301663399, 0.01252529863268137, -0.009337371215224266, 0.011701570823788643, 0.003844881197437644, -0.009870484471321106, -0.004384005442261696, -0.015221437439322472, -0.02201247401535511, 0.020946767181158066, -0.00006720807868987322, -0.007401395123451948, -0.0019296063110232353, 0.005130011588335037, -0.011070270091295242, -0.026959527283906937, 0.01440059021115303, 0.004285057075321674, -0.008690333925187588, 0.004982120357453823, -0.013779234141111374, 0.031159816309809685, 0.016241373494267464, -0.026491956785321236, 0.002397970063611865, -0.00980088859796524, 0.024152319878339767, 0.00010042969370260835, -0.0013841812033206224, 0.007173618301749229, 0.008776701986789703, 0.003274514339864254, 0.010713544674217701, 0.01897631585597992, 0.031732503324747086, 0.0067432718351483345, -0.009131076745688915, 0.007036559749394655, 0.004340914078056812, -0.00019524595700204372, 0.01697535626590252, -0.010201066732406616, -0.0003700926899909973, -0.0034575185272842646, 0.008000116795301437, -0.00762633141130209, -0.005480404943227768, 0.04831845685839653, 0.012158774770796299, 0.0033636977896094322, 0.0015831892378628254, 0.03118286095559597, -0.01264146901667118, 0.013189873658120632, -0.0006692204624414444, -0.03101997636258602, 0.0255289189517498, -0.0012451910879462957, -0.0013573731994256377, 0.0074351998046040535, -0.007047762628644705, -0.021873977035284042, -0.013065970502793789, -0.010854043997824192, 0.0036250457633286715, 0.005736696068197489, -0.031013429164886475, -0.0046861786395311356, 0.016937077045440674, -0.009457714855670929, -0.014252698048949242, -0.015637099742889404, -0.014630204066634178, 0.004160333424806595, 0.015730323269963264, 0.0070175109431147575, -0.01416868157684803, 0.03432770073413849, -0.022631419822573662, 0.01287863776087761, 0.0156516432762146, -0.008837415836751461, -0.01519002765417099, -0.01612439751625061, 0.011530840769410133, 0.010915150865912437, 0.007984917610883713, -0.028184333816170692, -0.0008343225345015526, 0.0228200051933527, -0.005655177403241396, 0.01816762425005436, 0.010813923552632332, -0.0009137392044067383, -0.016447264701128006, 0.021741554141044617, -0.0019404222257435322, -0.025977477431297302, -0.011640176177024841, -0.005008949898183346, 0.026806864887475967, 0.004142384976148605, 0.013329584151506424, -0.0025390274822711945, 0.0004583639674820006, 0.07249871641397476, 0.010910282842814922, 0.009715143591165543, -0.01756325364112854, -0.0011606649495661259, -0.0036015338264405727, -0.0070189498364925385, 0.015607452020049095, -0.02550382912158966, -0.01656331680715084, 0.010478166863322258, -0.013075018301606178, 0.0029603075236082077, 0.013757877051830292, 0.000340157188475132, -0.007966884411871433, -0.025083770975470543, 0.0423000194132328, 0.011605599895119667, 0.023293588310480118, 0.0032355990260839462, -0.016689270734786987, -0.0010678539983928204, -0.017780713737010956, -0.022339334711432457, -0.029458990320563316, 0.024263720959424973, -0.015505120158195496, -0.02675868570804596, 0.009892786853015423, -0.009748898446559906, -0.02941141650080681, -0.0065909093245863914, -0.016061104834079742, 0.0038526072166860104, -0.014530294574797153, 0.0036076782271265984, -0.000045703258365392685, 0.011314023286104202, 0.012925032526254654, -0.010323002934455872, -0.014704265631735325, 0.02143208496272564, 0.023262325674295425, -0.009328994899988174, 0.006889943033456802, -0.007197946775704622, 0.0005864399718120694, 0.008398618549108505, 0.0020360187627375126, -0.00027186586521565914, -0.018434081226587296, 0.012761101126670837, 0.004472841043025255, -0.02085573598742485, 0.0015075970441102982, 0.008801016956567764, 0.0001268875494133681, -0.0004139905795454979, -0.007517312653362751, 0.016292817890644073, 0.00025851023383438587, 0.011259036138653755, 0.006230379920452833, 0.005033917259424925, -0.018870292231440544, -0.02726076915860176, 0.018099423497915268, -0.004253502003848553, 0.007965647615492344, -0.005162141285836697, 0.0318651907145977, -0.0006921769818291068, -0.012228107079863548, -0.025980614125728607, 0.0033677350729703903, 0.018685804679989815, 0.03903428465127945, 0.03515863046050072, -0.003540405770763755, 0.00970542710274458, 0.010997061617672443, 0.0022239682730287313, 0.0026761828921735287, 0.001244502840563655, 0.011016248725354671, -0.013349943794310093, -0.07487684488296509, -0.01464061625301838, 0.012898195534944534, -0.005798778031021357, 0.013170089572668076, 0.001954103820025921, -0.009354611858725548, -0.0019521807553246617, 0.005819276906549931, 0.00532809691503644, -0.008984287269413471, 0.0017369943670928478, 0.004164154641330242, -0.014280046336352825, 0.009049286134541035, -0.01200604997575283, -0.016249241307377815, -0.0015526383649557829, -0.010915807448327541, -0.004623104818165302, -0.019804729148745537, -0.0027053130324929953, 0.011699767783284187, 0.005872753448784351, -0.006252280902117491, -0.08110038936138153, 0.013867697678506374, 0.0025197863578796387, -0.013932169415056705, 0.00589442253112793, 0.012185965664684772, 0.01050778292119503, -0.008949007838964462, -0.011022061109542847, -0.014148600399494171, 0.013588832691311836, 0.031904708594083786, -0.008294448256492615, -0.010761683806777, -0.01050581969320774, -0.014086760580539703, 0.010407564230263233, 0.004766514524817467, 0.013583831489086151, 0.03157021105289459, -0.025808990001678467, 0.015328725799918175, -0.005231920629739761, 0.017480041831731796, -0.00996515154838562, -0.00016548112034797668, -0.011014734394848347, 0.01128538977354765, 0.006576228886842728, -0.019288336858153343, 0.005300219636410475, -0.01574891060590744, -0.014281297102570534, -0.0016266601160168648, -0.001829573418945074, -0.016417741775512695, -0.01394733227789402, -0.004872577730566263, -0.010723208077251911, -0.025450218468904495, 0.0012960967142134905, -0.007333756424486637, 0.0005600834265351295, 0.020113859325647354, -0.015402734279632568, -0.012608480639755726, 0.0017686854116618633, -0.00690326327458024, 0.01773754321038723, -0.011155109852552414, -0.00047545554116368294, 0.002342779189348221, 0.02485225535929203, -0.002190767787396908, 0.002943117171525955, 0.03581204265356064, -0.008430412970483303, 0.04553445056080818, -0.0024855826050043106, 0.0008065708680078387, -0.019260123372077942, -0.009276269935071468, 0.003933443687856197, 0.07193845510482788, -0.005767790600657463, 0.016168804839253426, 0.0032901272643357515, -0.002098856959491968, 0.000049972906708717346, -0.0005825641565024853, -0.0054188985377550125, -0.0109235979616642, -0.0012572701089084148, 0.014796807430684566, -0.014440525323152542, 0.016337649896740913, 0.013195157051086426, 0.02279321849346161, 0.0033332067541778088, -0.010848617181181908, -0.01213071495294571, -0.01670921966433525, -0.00030450685881078243, -0.00191843556240201, 0.0070913140662014484, 0.001455201068893075, 0.016362972557544708, -0.004131407476961613, -0.01429013442248106, 0.00044870562851428986, -0.008708108216524124, -0.020158449187874794, 0.0015051225200295448, 0.01739984191954136, -0.01635272055864334, 0.002581601496785879, 0.0007269277703016996, 0.020176783204078674, -0.011224673129618168, 0.00474884919822216, 0.00566329900175333, -0.0197086650878191, -0.009359175339341164, 0.019333604723215103, 0.008579282090067863, 0.0012269067810848355, -0.023100391030311584, 0.011339465156197548, 0.01881757751107216, 0.012454324401915073, -0.014386351220309734, 0.005433955229818821, 0.013109034858644009, 0.01779893785715103, 0.0015353108756244183, -0.024409014731645584, -0.01830432377755642, 0.005355927627533674, -0.01407264731824398, -0.008294275030493736, 0.002047809073701501, -0.008884375914931297, -0.014717819169163704, 0.0032309377565979958, -0.022861996665596962, -0.0038707267958670855, -0.027749424800276756, 0.0219594556838274, -0.02291620522737503, -0.0036687212996184826, -0.011580311693251133, 0.019485659897327423, 0.02029452472925186, -0.004073820076882839, -0.02942761220037937, 0.010873427614569664, 0.016707919538021088, 0.03964244946837425, 0.017334582284092903, -0.002253892831504345, -0.006998545024544001, 0.013365047052502632, 0.007859827019274235, -0.010322798043489456, 0.03519734367728233, -0.005653920117765665, 0.004359325394034386, 0.019370853900909424, -0.0065564545802772045, 0.0021433152724057436, 0.011154618114233017, -0.004165329039096832, 0.013359501957893372, 0.009673912078142166, 0.010134505107998848, 0.011381832882761955, 0.010478779673576355, 0.013856219127774239, 0.03322400897741318, 0.0009437669068574905, 0.010368595831096172, -0.011387690901756287, -0.010886402800679207, -0.010136907920241356, -0.007192153483629227, -0.0003407848998904228, 0.005924862809479237, 0.014084850437939167, -0.0007598435040563345, 0.019993476569652557, -0.005445715039968491, -0.00993284210562706, -0.0256611630320549, 0.007487897761166096, -0.008452001959085464, -0.002150242915377021, 0.0005174931138753891, 0.010288247838616371, -0.002548235934227705, -0.0012472299858927727, 0.003928445279598236, -0.024091346189379692, -0.010138449259102345, -0.03412872180342674, 0.010166727006435394, -0.002964181825518608, 0.014130430296063423, -0.05268780514597893, -0.020169079303741455, -0.007986471056938171, 0.014654915779829025, -0.0015219163615256548, -0.022980961948633194, 0.003866025945171714, 0.014109402894973755, 0.010313283652067184, 0.005416036583483219, -0.017292499542236328, 0.012077566236257553, 0.013477708213031292, 0.007991854101419449, 0.01570708677172661, -0.013439817354083061, -0.024261565878987312, -0.02106906846165657, -0.0029607978649437428, 0.008945053443312645, 0.006950099021196365, 0.003710612189024687, 0.009855424985289574, 0.020086005330085754, -0.0004555865889415145, -0.00025605829432606697, 0.0071999626234173775, 0.003864006604999304, 0.003929800353944302, -0.005419871304184198, -0.01835213229060173, 0.015922242775559425, 0.0022656437940895557, 0.01582697033882141, -0.030657056719064713, 0.002779699396342039, -0.0025565708056092262, 0.04390128329396248, 0.03258081153035164, 0.0032839307095855474, 0.00796152651309967, 0.0000813123770058155, -0.0050992537289857864, 0.021681953221559525, -0.0286562480032444, 0.0030811121687293053, -0.010361702181398869, -0.03796091303229332, 0.002542384434491396, 0.015337254852056503, -0.01028173603117466, -0.013430940918624401, -0.02606057934463024, -0.0039056662935763597, 0.022001681849360466, 0.008140354417264462, -0.005156742408871651, 0.011983169242739677, 0.01137509010732174, -0.00635001715272665, -0.0035000259522348642, -0.01286253146827221, -0.003924917429685593, -0.003064108546823263, -0.0029075411148369312, 0.015789803117513657, -0.00874305423349142, 0.015594689175486565, -0.0005636099958792329, 0.025603625923395157, 0.011780312284827232, -0.01530052162706852, 0.001633060397580266, -0.0015385558363050222, 0.0040437448769807816, -0.0049140797927975655, 0.008554091677069664, -0.018035536631941795 ]
[ 0.571117639541626, 0.006307958625257015, 0.08999491482973099, 0.06575886160135269, -0.019850267097353935, 0.06476636230945587, -0.008731377311050892, -0.11535826325416565, -0.28971797227859497, -0.4691142439842224, 0.0759047269821167, 0.5045008659362793, -0.05969902127981186, -0.10312943160533905, -0.058847080916166306, 0.5463277697563171, 0.5711288452148438, 0.24243579804897308, -0.3740111291408539, -0.6120125651359558, -0.28323280811309814, -0.15613046288490295, 0.3558262884616852, 0.011793304234743118, 0.29592981934547424, 0.005958760157227516, -0.12553437054157257, 0.03875689581036568, 0.23396039009094238, 0.043496739119291306, -0.4630514085292816, 0.34650254249572754, -0.33755773305892944, -0.08590730279684067, -0.14459460973739624, -0.0013211186742410064, -0.30405616760253906, -0.04646782949566841, 0.03263470157980919, 0.046156395226716995, -0.5774199366569519, -0.008165695704519749, -0.25027525424957275, 0.43161827325820923, -0.04544134438037872, -0.017653653398156166, -0.826128363609314, 0.5240826606750488, -0.0012214547023177147, 0.2524075210094452, 0.15127187967300415, 0.12142404168844223, 0.09094630181789398, 0.1117556244134903, 0.12859830260276794, -0.6633018255233765, -0.2428547888994217, -0.1659942865371704, 0.10057111829519272, -0.6878183484077454, -0.002725625177845359, 0.48085322976112366, -0.4789224863052368, 0.3684612810611725, -0.1299969106912613, 0.44462859630584717, 0.039496831595897675, 0.10613366961479187, -0.3940615653991699, 0.20902717113494873, 0.06632816791534424, -0.12787331640720367, -0.26771047711372375, 0.09874899685382843, 0.06399921327829361, 0.024780120700597763, 0.1550787091255188, -0.14262786507606506, 0.04667530581355095, 0.1892014741897583, 0.3472254276275635, -0.033748168498277664, 0.6717507243156433, -0.3243160545825958, 0.6284953355789185, 0.041179582476615906, -0.25670790672302246, 0.8242461681365967, -0.2538805305957794, -0.6257055997848511, -0.15091203153133392, 0.06964107602834702, 0.13725578784942627, 0.1840425580739975, -0.19012635946273804, 0.6423137784004211, 0.6384873390197754, -0.3636435270309448, 0.20907945930957794, 0.041991084814071655, 0.0840160921216011, -0.2479563057422638, -0.027022432535886765, -0.36346787214279175, -0.28337088227272034, -0.3443356156349182, -0.1549009382724762, -0.1049940437078476, -0.650375247001648, 0.4504072964191437, -0.6754587292671204, 0.10298511385917664, -0.0040208566933870316, -0.23535215854644775, -0.22491836547851562, -0.03859521076083183, -0.028034253045916557, 0.1610095351934433, -0.024816950783133507, 0.25630587339401245, -0.18937556445598602, 0.7842298150062561, -0.17771382629871368, 0.7144887447357178, 0.009496881626546383, 0.19737079739570618, 0.25186100602149963, 0.11156468093395233, -0.055939931422472, 0.47729742527008057, 0.18774239718914032, 0.4906702935695648, -0.1441550850868225, 0.09501320868730545, 0.0632736012339592, 0.07818076759576797, 0.4842924177646637, 0.4404710531234741, 0.35544881224632263, 0.10726030170917511, -0.5446987748146057, -0.2205229550600052, -0.47085970640182495, 0.03232230246067047, -0.030242420732975006, -0.8072003722190857, -0.41721639037132263, 0.19860805571079254, 0.3386768698692322, -0.11084447801113129, -0.03464116156101227, -0.4081563949584961, -0.14338263869285583, -0.16764815151691437, -0.17599214613437653, 0.11065030843019485, -0.054378263652324677, -0.04889068379998207, -0.12960639595985413, -0.08453574031591415, 0.4623596966266632, 0.0514552928507328, -0.2185467630624771, -0.061657775193452835, 0.6108929514884949, -0.0479806512594223, 0.12719781696796417, -0.019955383613705635, -0.007532825227826834, -0.07024216651916504, -0.3765416145324707, -0.2885953485965729, -0.041092194616794586, -0.5730846524238586, -0.08753197640180588, 0.24276861548423767, -0.3088108003139496, 0.13563621044158936, -0.005452122539281845, 0.25070151686668396, -0.7006723284721375, -0.35212448239326477, -0.19052188098430634, -0.8232535123825073, 0.0766962319612503, -0.08889369666576385, 0.5526074171066284, -0.49487435817718506, -0.07165362685918808, 0.018497824668884277, -0.3608613908290863, -0.2663838565349579, 0.6876805424690247, -0.4932715594768524, 1.5931936502456665, -0.3838026821613312, 0.10773662477731705, 0.8881508708000183, 0.12866364419460297, 0.07444357126951218, 0.2801567614078522, -0.3387593924999237, 0.6437710523605347, -0.03537377342581749, -0.6535488963127136, 0.4277864992618561, 0.3203839361667633, -0.14993520081043243, 0.3251314163208008, -0.17180627584457397, 0.5945093631744385, -0.14436975121498108, -0.1642126739025116, -0.23135265707969666, 0.2947063446044922, -0.35325077176094055, -0.1537918597459793, -0.2741681933403015, -0.29164355993270874, -0.1912764012813568, -0.12203516811132431, -0.43798553943634033, 0.7427501082420349, 0.32705754041671753, 0.04547125846147537, 0.8893272280693054, 0.37339961528778076, 0.03792097792029381, 0.6528933644294739, -0.4098467230796814, 0.04307194799184799, -0.06216967850923538, -0.08930064737796783, 0.08746519684791565, -0.4126526415348053, 0.02880779467523098, 0.07482943683862686, -0.19568303227424622, -0.302869975566864, -0.27851608395576477, 0.10816340148448944, 0.6644738912582397, -0.5159539580345154, -0.009983857162296772, -0.01697203330695629, -0.21092940866947174, -0.10112971067428589, 0.2166367769241333, -0.765012800693512, 0.08545520901679993, -0.11884112656116486, 0.4521263539791107, 0.266605019569397, -0.5944007635116577, -0.1717309206724167, 0.11182928830385208, -0.06270289421081543, -0.14110009372234344, 0.291213721036911, -0.6575645804405212, 0.02634532004594803, 0.14823564887046814, 0.33225736021995544, 0.27985331416130066, -0.32135480642318726, -0.28604722023010254, -0.7199508547782898, -0.38980674743652344, 0.9869771003723145, 0.4106373190879822, 0.9413185715675354, -0.1682131588459015, -0.5710453391075134, -0.03346088156104088, -0.4490708112716675, -0.5687609314918518, 0.2767317593097687, 0.3986612856388092, -0.5345911383628845, -0.5445752739906311, -0.1958477795124054, 0.27557963132858276, 0.9956121444702148, -0.12701013684272766, -0.43654078245162964, 0.03640828654170036, -0.3224707841873169, -0.13589438796043396, -0.18463343381881714, -0.2599802315235138, -0.13696447014808655, 0.32376548647880554, 0.34406349062919617, -0.04525397717952728, 0.46164751052856445, 0.1445620208978653, 0.2587197721004486, 0.6279786825180054, 0.46832379698753357, -0.4346579611301422, -0.3132275640964508, 0.406554639339447, -0.4221799969673157, 0.09944754838943481, -0.13378997147083282, 0.047788698226213455, -0.3158062696456909, 0.27735862135887146, -6.0879597663879395, 0.2162763476371765, 0.13298867642879486, -0.3627323806285858, 0.4718436598777771, 0.18339607119560242, 1.0538971424102783, -0.06957132369279861, -0.010297378525137901, 0.15540999174118042, -0.06514573842287064, 0.7132676243782043, 0.10488337278366089, 0.16140401363372803, -0.3522188663482666, -0.26805099844932556, -0.13483332097530365, -0.2529090344905853, 0.45874473452568054, 0.3271721303462982, 0.023550620302557945, 0.3299427628517151, 0.29948121309280396, 0.5635408759117126, -0.0881442055106163, 0.2950507402420044, -1.0019307136535645, 0.20361033082008362, -0.0839485451579094, -0.45620253682136536, 0.23901423811912537, -0.5438382029533386, 0.09611811488866806, -0.25030553340911865, 0.19142436981201172, -0.10761209577322006, -0.01923634484410286, -0.2454044222831726, -0.09849988669157028, -0.18823204934597015, -0.18735086917877197, 0.4457622468471527, -0.23914943635463715, 0.13487832248210907, 0.3556440472602844, 0.33505135774612427, 0.05207552760839462, -0.1968899965286255, -0.13683298230171204, 0.8808251619338989, -0.31481316685676575, -0.20047703385353088, 0.14456236362457275, 0.12650583684444427, 0.521180272102356, -0.010147268883883953, -0.12429274618625641, 0.06436605006456375, -0.17336291074752808, 0.054316822439432144, -0.2784736752510071, -0.08608628064393997, -0.32103630900382996, -0.8425774574279785, -0.006990500725805759, 0.2437034547328949, -0.600655734539032, -0.4270915687084198, 0.34585103392601013, -0.22868689894676208, -0.23489020764827728, 0.32133662700653076, 0.29524943232536316, -0.688255786895752, 0.3240374028682709, -0.2699292302131653, -0.220201775431633, -0.14056181907653809, -0.017011843621730804, -0.20246312022209167, -0.20131610333919525, 0.03889501094818115, 0.44382748007774353, 0.03137744218111038, -0.14078393578529358, 0.26967737078666687, -0.31007108092308044, -0.5147252082824707, 0.2289045751094818, 0.4761081337928772, 0.9882743954658508, -0.15211187303066254, -0.07090680301189423, 0.33616507053375244, 0.30664488673210144, 0.8380038142204285, 0.29527851939201355, 0.6848635673522949, 0.34583401679992676, 0.16304828226566315, 0.713770866394043, -0.17948110401630402, -0.5016706585884094, -0.7917611598968506, -0.22997204959392548, 0.12805260717868805, -0.5268940925598145, 0.11394871026277542, 0.5338518619537354, -1.2209093570709229, -0.12466926872730255, 0.04686250910162926, -0.32376793026924133, -0.07307250797748566, 0.40263989567756653, -0.46936389803886414, -0.3710483908653259, -0.09610199183225632, 0.6416873931884766, -0.482027143239975, 0.38336649537086487, 0.23007622361183167, -0.39566317200660706, 0.30610135197639465, -0.02243529073894024, -0.06345228105783463, 0.09456749260425568, 0.26195016503334045, -0.5320216417312622, -0.057265039533376694, -0.03793890401721001, 0.613235592842102, -0.15313072502613068, 0.11572577804327011, 0.11199809610843658, -0.529824435710907, -0.2599559724330902, 0.37420031428337097, 0.45318272709846497, -0.03431033715605736, 0.011563673615455627, -0.2548728287220001, -0.3547474145889282, -0.09066339582204819, 0.3922182023525238, 0.09596414119005203, -0.5873825550079346, 0.0016319698188453913, -0.23533488810062408, -0.11189313977956772, 0.4646373987197876, -0.26817840337753296, 0.32950741052627563, 0.02320845052599907, -0.3519511818885803, 0.09038496017456055, 0.2951676547527313, 0.2611493766307831, 0.18728095293045044, -0.24926719069480896, 0.34940963983535767, -0.07747481763362885, -1.031812310218811, 0.006797029636800289, 0.03099033236503601, -0.5475136637687683, 0.1474311649799347, -0.7561537623405457, 0.011133400723338127, -0.13748861849308014, -0.18537060916423798, -0.3022969663143158, 0.07621490210294724, 0.04980966076254845, -0.00020173161465208977, -0.10823050886392593, -0.3944281339645386, 0.5800486207008362, -0.09692135453224182, -0.025694094598293304, 0.4982685446739197, -0.4014671742916107, -0.2454828917980194, 0.3159644901752472, 0.5827112197875977, 0.031849220395088196, 0.18945370614528656, -0.15054944157600403, -0.19266991317272186, -0.461849570274353, 0.3577132523059845, 0.1541835516691208, -0.025161392986774445, 0.04429605230689049, 0.08486004918813705, -0.08463519811630249, 0.20411884784698486, 0.23494337499141693, -0.16970546543598175, -0.4185348153114319, 0.35819339752197266, 0.14580349624156952, -0.12835462391376495, 0.5987321734428406, 0.36782750487327576, -0.04234981909394264, -0.15767501294612885, 0.30177590250968933, -0.35338208079338074, -0.5086453557014465, -0.02547614462673664, -0.648952841758728, -0.05122116580605507, 0.0909697487950325, -0.16138434410095215, -0.1140521690249443, 0.3405722379684448, -0.25718849897384644, -0.32565197348594666, 0.2916094660758972, 0.2164691835641861, -0.009338592179119587, -0.12090356647968292, 0.29965901374816895, -0.15373186767101288, -0.18175926804542542, 0.26858580112457275, -1.1911227703094482, 0.49684494733810425, -0.16961978375911713, -0.7324700951576233, 0.0674666315317154, 0.12152045220136642, 0.2949841320514679, -0.6912172436714172, -0.1182587668299675, -0.29980847239494324, 0.11099833250045776, -0.17063263058662415, 0.4835889935493469, 0.28067997097969055, 0.17990398406982422, -0.43722182512283325, -0.19824890792369843, -0.02928011864423752, 0.5567388534545898, 0.30025365948677063, -0.656762421131134, -0.08047032356262207, 0.1167425736784935, 0.7724548578262329, 0.05077068507671356, -0.024952318519353867, -0.02742829918861389, 0.5414687395095825, -0.16188819706439972, -0.14688841998577118, -0.4665762484073639, -0.164132222533226, 0.2303156852722168, -0.22684799134731293, -0.3734879791736603, -0.31194204092025757, -0.046622198075056076, 0.10982481390237808, -0.32298219203948975, -0.2441706359386444, -0.6130470633506775, 0.6533957123756409, -0.5028938055038452, -0.32006657123565674, 0.10465475916862488, 0.9154198169708252, 0.3112758696079254, 0.3997201919555664, 0.2829058766365051, -0.1970459669828415, 0.30967065691947937, 0.11365927755832672, 0.1058751791715622, -0.08638668060302734, -0.9152936339378357, 0.29661163687705994, -0.6468707323074341, 0.5209206342697144, -0.6262130737304688, 0.5839545130729675, -0.3723713457584381, -0.0640903189778328, -0.2654303014278412, -0.2747644782066345, 0.11344335228204727, -0.28352832794189453, -0.5244632363319397, -0.040627043694257736, 0.20058239996433258, -0.1677785962820053, 0.22888530790805817, 0.23151472210884094, -0.5232059955596924, -0.45829224586486816, 0.1698809266090393, 0.3169635236263275, -0.08965534716844559, -0.026195906102657318, 0.24104756116867065, 0.2444753497838974, -0.27636823058128357, -0.4188324511051178, -0.1012953445315361, -0.014992610551416874, 0.006064504850655794, 0.2569427490234375, 0.37957167625427246, -0.19316357374191284, 0.1561494618654251, 0.11538159102201462, -0.015665043145418167, 0.5606064796447754, 0.23547686636447906, 0.31128108501434326, 0.37471041083335876, 0.7789862155914307, -0.15052618086338043, -0.019217099994421005, 0.2393198311328888, 0.2465900033712387, 0.3682529032230377, 0.1251443773508072, 0.18411698937416077, 0.6513698101043701, 0.258476585149765, 0.4575929045677185, 0.4879223108291626, 0.5115320682525635, 0.1286768615245819, 0.5332286953926086, -0.40599527955055237, -0.24245165288448334, -0.09656504541635513, 0.9681621193885803, 0.4375778138637543, 0.026166070252656937, -0.5095871090888977, 0.1493227481842041, 0.4534943103790283, 0.20265774428844452, 0.38560381531715393, -0.23764914274215698, 0.0869424119591713, 0.15148790180683136, -0.221329927444458, -0.5530514717102051, 0.09727035462856293, -0.5592519640922546, 0.37196317315101624, 0.40771162509918213, -0.3751409351825714, -0.6247765421867371, 0.4372752904891968, -0.3414931297302246, 0.3840436637401581, 0.1837143450975418, 0.570074200630188, -0.20722267031669617, 0.1525689959526062, 0.07951813191175461, 0.16004681587219238, 0.17126905918121338, -0.21713729202747345, -0.14695924520492554, -0.3082309365272522, -0.3319442868232727, -0.2416325807571411, 0.078130804002285, -0.7580993175506592, 0.24718594551086426, -0.09850399941205978, -0.22041970491409302, 0.5372725129127502, -0.06901071965694427, 0.051589783281087875, -0.3639233112335205, -0.47785016894340515, 0.28687500953674316, -0.2847762107849121, -0.5881158709526062, -0.012111659161746502, -0.48122715950012207, 0.2839806079864502, -0.18589548766613007, -0.5103674530982971, 0.2270188182592392, 0.3697454631328583, 0.25505444407463074, -0.0010992559837177396, 0.15252754092216492, 0.3279225826263428, 0.001188719179481268, 0.39365246891975403, 0.18859079480171204, 0.6182441711425781, -0.36154982447624207, 0.23534192144870758, -0.47614434361457825, 0.7180222272872925, -0.6924165487289429, 0.062071293592453, -0.7077852487564087, -0.09687581658363342, 0.5550881028175354, 0.8798565864562988, -0.1596825122833252, 0.061917681246995926, 0.31555378437042236, -0.029648613184690475, 0.43258172273635864, -0.5645872950553894, -0.19654682278633118, -0.4883384704589844, -0.40755540132522583, -0.6213617324829102, 0.4166707396507263, 0.05489983782172203, -0.4552691578865051, -0.2134949415922165, 0.6258758306503296, 0.525641143321991, -0.3581547141075134, 0.31844550371170044, -0.445483535528183, -0.12218915671110153, -0.7969384789466858, -0.0010351331438869238, -0.5367500185966492, 0.2935316860675812, -0.14896118640899658, 0.21199922263622284, 0.01122508104890585, -0.46684232354164124, 0.26589637994766235, 0.16789521276950836, 0.04839073866605759, 0.35136985778808594, 0.08173222839832306, 0.18601730465888977, -0.33337754011154175, -0.6100359559059143, -0.6332100629806519, 0.15994063019752502, -0.10781022906303406, -0.38828569650650024, 0.06894134730100632, -0.02101004309952259, -0.04485443979501724, -0.2745305001735687, -0.19258899986743927, 0.017831144854426384, 0.015247584320604801, -0.050110988318920135 ]
BACKGROUND Lobular involution, or age-related atrophy of breast lobules, is inversely associated with breast cancer risk, and mammographic breast density (MBD) is positively associated with breast cancer risk. METHODS To evaluate whether lobular involution and MBD are independently associated with breast cancer risk in women with benign breast disease, we performed a nested cohort study among women (n = 2666) with benign breast disease diagnosed at Mayo Clinic between January 1, 1985, and December 31, 1991 and a mammogram available within 6 months of the diagnosis. Women were followed up for an average of 13.3 years to document any breast cancer incidence. Lobular involution was categorized as none, partial, or complete; parenchymal pattern was classified using the Wolfe classification as N1 (nondense), P1, P2 (ductal prominence occupying <25%, or >25% of the breast, respectively), or DY (extremely dense). Hazard ratios (HRs) and 95% confidence intervals (CIs) to assess associations of lobular involution and MBD with breast cancer risk were estimated using adjusted Cox proportional hazards model. All tests of statistical significance were two-sided. RESULTS After adjustment for MBD, having no or partial lobular involution was associated with a higher risk of breast cancer than having complete involution (none: HR of breast cancer incidence = 2.62, 95% CI = 1.39 to 4.94; partial: HR of breast cancer incidence = 1.61, 95% CI = 1.03 to 2.53; P(trend) = .002). Similarly, after adjustment for involution, having dense breasts was associated with higher risk of breast cancer than having nondense breasts (for DY: HR of breast cancer incidence = 1.67, 95% CI = 1.03 to 2.73; for P2: HR of breast cancer incidence = 1.96, 95% CI = 1.20 to 3.21; for P1: HR of breast cancer incidence = 1.23, 95% CI = 0.67 to 2.26; P(trend) = .02). Having a combination of no involution and dense breasts was associated with higher risk of breast cancer than having complete involution and nondense breasts (HR of breast cancer incidence = 4.08, 95% CI = 1.72 to 9.68; P = .006). CONCLUSION Lobular involution and MBD are independently associated with breast cancer incidence; combined, they are associated with an even greater risk for breast cancer.
[ -0.005851359106600285, 0.002929085399955511, -0.015440352261066437, 0.0042356401681900024, 0.026323318481445312, -0.006811284925788641, 0.010096975602209568, 0.02495282143354416, -0.006728796288371086, 0.02436944469809532, -0.007121547590941191, 0.012826846912503242, -0.003203350817784667, 0.021652746945619583, -0.045798588544130325, 0.006304292939603329, -0.047114770859479904, 0.006525679491460323, 0.009422686882317066, -0.003304016776382923, 0.024727560579776764, -0.020639846101403236, 0.00957200862467289, 0.016989372670650482, -0.00601609144359827, -0.005059714429080486, -0.01727086678147316, 0.0030656757298856974, 0.009947428479790688, -0.007179846055805683, -0.01068819873034954, 0.006545992102473974, -0.005789986811578274, 0.013688178732991219, 0.011946352198719978, -0.002373463474214077, -0.006040604785084724, 0.01500809658318758, 0.004097664728760719, -0.00704287551343441, -0.0026232213713228703, -0.015781622380018234, 0.0078452592715621, -0.005945576820522547, -0.010659273713827133, -0.06650219857692719, -0.004331123549491167, 0.005066920071840286, -0.015919726341962814, 0.0048404596745967865, -0.006757436785846949, -0.02258356846868992, -0.01640157774090767, -0.014819243922829628, -0.006117898039519787, -0.0019245501607656479, 0.016513589769601822, -0.012743387371301651, 0.003387623932212591, 0.0002703936770558357, -0.02449589967727661, 0.021601758897304535, -0.0028353577945381403, -0.02517898753285408, -0.003232518443837762, -0.06673243641853333, 0.029256056994199753, -0.0009595663286745548, -0.02585107833147049, -0.025768600404262543, 0.0008686287328600883, 0.009925195015966892, 0.026066340506076813, -0.005578272044658661, -0.009352551773190498, 0.01696840301156044, 0.0004962075036019087, -0.010477252304553986, 0.02477053739130497, 0.006680060178041458, -0.022752918303012848, 0.0016536363400518894, 0.0021187560632824898, 0.02171206846833229, 0.005719122476875782, -0.003201728221029043, -0.03686325252056122, -0.0009561493061482906, 0.022165898233652115, 0.0062682959251105785, 0.014923801645636559, 0.012096196413040161, -0.04170016944408417, -0.002801968716084957, -0.01422032993286848, -0.021687285974621773, 0.02033580094575882, 0.0032647852785885334, 0.020142994821071625, 0.02329643815755844, -0.025885814800858498, -0.0012340137036517262, 0.02101881429553032, -0.029468921944499016, -0.0047834767028689384, 0.010281569324433804, 0.014436415396630764, -0.0011943366844207048, 0.05185800790786743, 0.014083067886531353, -0.020753072574734688, 0.008545619435608387, -0.01193934679031372, 0.017198685556650162, 0.021607890725135803, -0.033552560955286026, 0.015277243219316006, -0.0021374619100242853, -0.002513452433049679, -0.015864983201026917, 0.016041293740272522, -0.00046520819887518883, -0.008217038586735725, 0.045012686401605606, 0.0070027499459683895, -0.00014329701662063599, 0.0027762872632592916, -0.019651837646961212, 0.037903979420661926, 0.011494286358356476, -0.0056810323148965836, 0.0010247844038531184, -0.0021959440782666206, 0.001597485039383173, 0.01777276024222374, 0.008898040279746056, -0.02881753258407116, -0.008519324474036694, 0.002145669888705015, -0.02275664359331131, -0.012347426265478134, 0.014049625024199486, 0.008985450491309166, 0.00024633322027511895, -0.003761744126677513, 0.002830573357641697, 0.001943749375641346, -0.006823410280048847, -0.017476094886660576, 0.0007062966469675303, -0.009363796561956406, 0.01655248925089836, -0.01317095011472702, -0.018673812970519066, 0.005440741777420044, -0.005347704980522394, -0.0002577094128355384, 0.036265648901462555, 0.01511446200311184, -0.011165112257003784, -0.02451721765100956, -0.0095056826248765, 0.022926196455955505, 0.00904830452054739, -0.008633377961814404, 0.0303035918623209, 0.011393038555979729, -0.01700417697429657, -0.0076142409816384315, 0.010518904775381088, -0.01600896194577217, 0.002140362048521638, 0.006946476176381111, 0.01243353821337223, 0.0036070565693080425, -0.013079505413770676, 0.035500966012477875, 0.008049827069044113, 0.0005379547365009785, 0.0664016604423523, 0.0030873091891407967, 0.009446426294744015, -0.003248917404562235, 0.009066510945558548, 0.003858197247609496, -0.003260203870013356, 0.008760764263570309, -0.015184742398560047, -0.0007153586484491825, -0.03695319592952728, -0.010191218927502632, -0.006675667129456997, -0.010534599423408508, -0.000058871228247880936, -0.03401539474725723, 0.0026944968849420547, 0.010687203146517277, 0.008753795176744461, -0.03383426368236542, 0.008085479028522968, 0.00990874134004116, -0.012544730678200722, 0.0030829624738544226, -0.02371690794825554, 0.0019342675805091858, 0.00944896973669529, 0.029699983075261116, -0.028655344620347023, 0.0019421568140387535, -0.0017708215164020658, 0.0019875240977853537, -0.01429709605872631, -0.015286516398191452, -0.012748932465910912, -0.0044206962920725346, -0.009421559050679207, -0.0028865663334727287, -0.004480917938053608, -0.0209979061037302, -0.012735064141452312, 0.005377609748393297, 0.005368703044950962, 0.016291161999106407, -0.01364079862833023, 0.012371044605970383, -0.019077574834227562, -0.0054593863897025585, 0.006379431113600731, 0.022854045033454895, 0.005429951008409262, -0.013048281893134117, -0.011989248916506767, -0.011343974620103836, 0.010367818176746368, 0.0018250418361276388, 0.004944914020597935, 0.013371028006076813, -0.007765849120914936, 0.02596288174390793, -0.019135242328047752, 0.0025739308912307024, -0.015843041241168976, -0.013249346986413002, -0.012793929316103458, 0.02108721062541008, 0.006962933111935854, 0.025444194674491882, 0.0005344823002815247, 0.009571777656674385, -0.03399268537759781, 0.008194138295948505, -0.019963758066296577, -0.010069135576486588, 0.025735992938280106, -0.022716037929058075, 0.028183044865727425, 0.009200640954077244, -0.02527833729982376, 0.022216176614165306, 0.001010826206766069, 0.005828813649713993, 0.012983571738004684, 0.007605495397001505, 0.006862855516374111, -0.0009352667257189751, 0.022947823628783226, 0.002440124051645398, 0.007794426754117012, -0.019595393911004066, 0.006758391857147217, 0.011749127879738808, -0.011715477332472801, -0.008727941662073135, -0.08049812912940979, -0.010485636070370674, -0.00538280513137579, 0.03288135305047035, 0.00858992338180542, -0.023943807929754257, 0.012864709831774235, 0.0010005510412156582, 0.0007550637237727642, -0.01957302913069725, -0.002890579402446747, -0.005994712933897972, 0.0016057102475315332, -0.0312894769012928, 0.0021706896368414164, 0.00031389447394758463, 0.010557670146226883, 0.0031667868606746197, -0.017850292846560478, -0.043578118085861206, 0.0038790374528616667, -0.0027965351473540068, -0.000637945719063282, 0.022084839642047882, -0.019391734153032303, -0.0062172068282961845, -0.0018462312873452902, -0.008858715184032917, 0.0032533458434045315, 0.0044839102774858475, 0.004084489308297634, -0.010054864920675755, -0.0044930847361683846, 0.022873062640428543, -0.014577928930521011, -0.023385703563690186, -0.0036156661808490753, -0.008775031194090843, -0.006782383657991886, 0.03220526874065399, -0.0112770926207304, 0.006584229879081249, 0.0243667084723711, -0.005964174866676331, 0.002002965658903122, 0.0024861006531864405, 0.005483311600983143, -0.003451703116297722, 0.01894114725291729, -0.03133317828178406, -0.017150618135929108, -0.006723473779857159, -0.03069366328418255, 0.015252910554409027, -0.015535913407802582, 0.013955981470644474, -0.012677363120019436, 0.0007634488865733147, -0.007094965316355228, -0.022000854834914207, 0.007752921897917986, -0.016817152500152588, 0.03122054412961006, 0.05254928022623062, 0.023483235388994217, 0.017347045242786407, 0.014587539248168468, -0.013941951096057892, 0.011120390146970749, 0.019633665680885315, 0.021037954837083817, -0.00008735537994652987, 0.004569076932966709, -0.016381246969103813, -0.013474646955728531, -0.005005178041756153, -0.013810751028358936, 0.005468613468110561, -0.0016415781574323773, -0.015889301896095276, -0.001247660955414176, 0.0015840539708733559, 0.0020329353865236044, -0.0033237573225051165, -0.02539224550127983, 0.005757743492722511, 0.010676882229745388, 0.04874296858906746, 0.017924068495631218, -0.01573958992958069, 0.03714007884263992, 0.012666434049606323, -0.000549395103007555, 0.010902781039476395, -0.008390376344323158, 0.0037529966793954372, -0.02287323586642742, -0.013833062723279, -0.01080139260739088, 0.00787277054041624, -0.0160541832447052, -0.0025298320688307285, -0.01019169483333826, -0.01082998514175415, -0.012197470292448997, 0.01849188283085823, 0.02620207704603672, 0.014712130650877953, -0.0036177283618599176, 0.0011233389377593994, 0.013985689729452133, -0.02340247668325901, -0.004392395727336407, 0.04104281961917877, 0.015133986249566078, 0.022391535341739655, -0.017723403871059418, -0.012088633142411709, 0.0723101943731308, 0.0002858000807464123, -0.005456236191093922, -0.0030139214359223843, 0.0057639675214886665, -0.033573538064956665, -0.015443673357367516, 0.0010034096194431186, -0.024613969027996063, 0.006029341369867325, 0.010478811338543892, -0.0006217944901436567, -0.006934843026101589, 0.0045731645077466965, -0.013138688169419765, 0.00223422865383327, 0.0034972073044627905, 0.007546825334429741, 0.03419000282883644, -0.0010899032931774855, -0.03061293438076973, 0.0017976431408897042, -0.02110467292368412, 0.000551942503079772, 0.023157134652137756, -0.010395295917987823, -0.010825634934008121, -0.015295793302357197, -0.01880543678998947, 0.0078046368435025215, -0.03378111124038696, 0.03421831876039505, -0.010814957320690155, -0.006072274874895811, 0.03208513557910919, -0.004169703461229801, -0.010484147816896439, -0.023029550909996033, 0.011223999783396721, -0.01684476062655449, -0.03248928487300873, -0.010782737284898758, -0.0014615331310778856, 0.007821017876267433, -0.009037896059453487, 0.0020076793152838945, -0.010753368958830833, -0.006564395502209663, -0.015608655288815498, 0.021458372473716736, -0.0024738989304751158, 0.004362273029983044, 0.012078878469765186, -0.005991652607917786, -0.01697501353919506, -0.02605075016617775, -0.013544785790145397, -0.01914673112332821, -0.023035936057567596, -0.008384058251976967, -0.0036601258907467127, -0.006228099577128887, 0.02504672482609749, 0.003053882624953985, -0.010523589327931404, -0.021891959011554718, 0.009364252910017967, -0.005511921364814043, 0.019759152084589005, -0.021909542381763458, 0.030980290845036507, 0.04576069116592407, -0.0379338338971138, 0.010432550683617592, -0.01831486076116562, -0.0005701472982764244, -0.02755027264356613, -0.03935593366622925, 0.022621871903538704, -0.01513619814068079, -0.009801271371543407, -0.004377163015305996, -0.0014481802936643362, -0.024770770221948624, 0.012442592531442642, -0.020271021872758865, -0.0033358281943947077, -0.07428784668445587, 0.010163137689232826, -0.013158449903130531, -0.010805480182170868, -0.014721294865012169, 0.012235475704073906, -0.01316709816455841, -0.015338657423853874, -0.03987208008766174, 0.008251646533608437, -0.028323538601398468, 0.00021309766452759504, -0.019676586613059044, 0.012175669893622398, 0.014350516721606255, 0.013929242268204689, -0.007053314242511988, -0.006220341194421053, -0.018056944012641907, -0.005697196815162897, 0.025138182565569878, 0.013030538335442543, -0.012582875788211823, 0.01297810673713684, -0.018991613760590553, -0.08098410069942474, 0.00815344788134098, -0.0075375353917479515, -0.00036877160891890526, -0.010619841516017914, -0.005396141204982996, 0.007773853838443756, -0.006506310310214758, -0.012384116649627686, -0.01849200762808323, -0.015059451572597027, -0.0005949200130999088, -0.016876814886927605, -0.010139431804418564, -0.006104288622736931, -0.012115009129047394, 0.029184216633439064, -0.006656507961452007, -0.03675214573740959, 0.016480576246976852, 0.02473260462284088, 0.014422358945012093, -0.0065994481556117535, -0.011318345554172993, -0.011083605699241161, -0.008192893117666245, -0.013256547972559929, 0.01642494462430477, -0.007634724490344524, -0.033698391169309616, -0.018941018730401993, -0.01858378015458584, -0.00040064379572868347, -0.03779267519712448, -0.040763936936855316, -0.005071428604424, -0.01197271142154932, 0.0025333352386951447, 0.00226922077126801, -0.01927550509572029, -0.004996441770344973, 0.00622820109128952, 0.026920977979898453, 0.00175659847445786, -0.021747983992099762, 0.0008766998071223497, 0.008141996338963509, -0.01425936259329319, -0.0011847049463540316, 0.008238421753048897, 0.012943075969815254, 0.006357547827064991, 0.015605872496962547, -0.011925975792109966, 0.003731820499524474, -0.0034361188299953938, -0.002263253089040518, -0.005434234626591206, 0.029621031135320663, 0.024305403232574463, 0.0030279599595814943, 0.01624758541584015, -0.0069634513929486275, 0.07160242646932602, 0.0026918172370642424, -0.002198907546699047, 0.002846919931471348, 0.00005534838419407606, 0.006595875136554241, -0.05970592051744461, -0.0015106750652194023, 0.00690881721675396, -0.019789010286331177, -0.02940106950700283, -0.020166128873825073, -0.004880937747657299, 0.016328303143382072, -0.01239552441984415, -0.008813123218715191, -0.004444660618901253, 0.016560787335038185, -0.04297379404306412, -0.02799629233777523, 0.04228605329990387, 0.030645329505205154, -0.0058762142434716225, 0.01540406420826912, -0.021066397428512573, 0.0034026955254375935, -0.016205763444304466, 0.01826469972729683, -0.017127305269241333, -0.021239321678876877, -0.005791668780148029, 0.014443187043070793, 0.010700412094593048, 0.0026308600790798664, 0.02940642274916172, 0.02746736630797386, -0.025549646466970444, 0.005470051430165768, 0.002042984589934349, 0.003609216772019863, -0.022414755076169968, -0.0028438246808946133, -0.0053337207064032555, 0.011573483236134052, 0.049391813576221466, -0.010046426206827164, 0.005688178353011608, 0.0013297796249389648, -0.008478760719299316, 0.0017637790879234672, -0.030691713094711304, 0.00943041779100895, 0.007589245215058327, -0.012020258232951164, 0.009764047339558601, -0.0078537967056036, -0.009565353393554688, 0.019630637019872665, -0.01914718933403492, 0.011428438127040863, 0.02935854345560074, -0.006603515241295099, -0.02030276320874691, -0.023589426651597023, 0.023717127740383148, -0.015621957369148731, 0.023545166477560997, -0.02061399072408676, -0.01746279001235962, 0.01318400539457798, 0.015620951540768147, -0.027778083458542824, 0.01341080293059349, 0.025502486154437065, -0.011355463415384293, -0.016167474910616875, 0.011252227239310741, 0.014264604076743126, 0.0018222485668957233, 0.010630656965076923, -0.0006341047119349241, -0.012247363105416298, 0.023540228605270386, -0.013363524340093136, -0.007186963222920895, 0.028042610734701157, -0.010662449523806572, 0.016161881387233734, -0.011915825307369232, 0.008495019748806953, 0.022378960624337196, -0.0005905628204345703, -0.00022551330039277673, 0.014471055008471012, 0.010842712596058846, 0.03310065343976021, 0.01284291036427021, -0.002096060896292329, -0.013609424233436584, 0.012716767378151417, -0.0003731215838342905, -0.007862517610192299, -0.03373616561293602, 0.0020825136452913284, -0.02482409030199051, -0.009019749239087105, -0.016654476523399353, -0.024030249565839767, 0.016283713281154633, 0.008795801550149918, -0.015855668112635612, -0.014662583358585835, 0.036981839686632156, -0.004221615381538868, 0.0011479159584268928, 0.01623774692416191, -0.0004171510227024555, 0.03471851348876953, 0.018192851915955544, -0.012165071442723274, -0.006551546975970268, 0.005889885127544403, 0.018569722771644592, 0.010777817107737064, 0.002613044111058116, -0.002555816201493144, -0.013890229165554047, 0.03604402020573616, -0.014475751668214798, 0.001056823879480362, 0.018492989242076874, -0.012500278651714325, -0.0013999911025166512, 0.023543454706668854, 0.0024838177487254143, 0.0023105740547180176, 0.0270997304469347, -0.015683913603425026, 0.010235758498311043, 0.02227286994457245, -0.0016121803782880306, 0.00011221237946301699, 0.001022647600620985, 0.009677361696958542, 0.011491312645375729, -0.013138586655259132, -0.020042922347784042, -0.0018245161045342684, 0.009008198045194149, -0.0021744268015027046, 0.0013625731226056814, -0.0035736868157982826, 0.0031362026929855347, -0.007505549117922783, 0.015045256353914738, 0.011272871866822243, 0.019620366394519806, 0.0480942577123642, 0.011089356616139412, -0.002247386611998081, -0.005651525687426329, -0.010928548872470856, -0.009564531967043877, -0.005416122730821371, 0.03606303781270981, 0.004120249301195145, -0.0030038857366889715, 0.0020365954842418432, -0.017110487446188927, 0.0021200247574597597, -0.004424699116498232, -0.019824808463454247, -0.022933509200811386, 0.02677926793694496, -0.022908944636583328, -0.017180360853672028, -0.0006219570059329271, 0.0009226661641150713, -0.005439721513539553, -0.0012781498953700066, -0.012892311438918114, -0.00019085919484496117, 0.006261416245251894, -0.014962276443839073, 0.0038122483529150486, -0.012913987040519714, 0.008491301909089088, 0.010803839191794395, -0.012419008649885654, -0.007180947344750166, 0.002118042204529047, 0.01314525306224823, -0.0019568088464438915, 0.006484132260084152, -0.0045813401229679585, 0.023523306474089622, -0.010803768411278725, 0.03740285336971283, -0.019865073263645172, -0.0076936944387853146, 0.0009932584362104535, -0.006474998779594898 ]
[ -0.055199965834617615, 0.15603889524936676, -0.07295204699039459, -0.34514904022216797, 0.3058192729949951, 0.9258535504341125, 0.17201636731624603, 0.4167926013469696, -0.44644221663475037, -0.05340072885155678, 0.14014993607997894, 0.41904088854789734, -0.011844112537801266, 0.004587965086102486, -0.34835267066955566, 0.43738341331481934, 0.774329423904419, 0.06517795473337173, -0.007815090008080006, -0.3722279965877533, -0.14693669974803925, -0.6222696900367737, 0.37403902411460876, 0.2673949599266052, -0.04620526731014252, 0.017443286255002022, 0.26564928889274597, -0.03513869270682335, 0.1970338523387909, 0.2790077328681946, -0.1977480798959732, 0.7583609223365784, 0.631089985370636, -0.4947700500488281, 0.08766432851552963, 0.05143866688013077, 0.0851668044924736, 0.15842971205711365, 0.12484633922576904, 0.2009805589914322, 0.1002359464764595, -0.20238667726516724, 0.09792682528495789, 0.315851628780365, -0.17180094122886658, 0.013846178539097309, -1.7682032585144043, 0.661474883556366, -0.18760105967521667, -0.07978202402591705, 0.2596282958984375, 0.3654243052005768, 0.6085935235023499, 0.07140887528657913, 0.014022056944668293, -0.024013450369238853, -0.24681368470191956, -0.28059816360473633, 0.49532416462898254, -0.2566024661064148, -0.16392268240451813, -0.0857086181640625, 0.24454836547374725, -0.06478770077228546, -0.6098476052284241, 0.42800280451774597, 0.005990614648908377, 0.28547152876853943, -0.48881372809410095, 0.06571441143751144, 0.2203187197446823, 0.045691341161727905, -0.1751374900341034, -0.2836535573005676, -0.14088034629821777, 0.6656955480575562, -0.12004396319389343, -0.04941779002547264, 0.5059353113174438, -0.22411306202411652, 0.005106003489345312, 0.0126778120175004, 0.49879056215286255, -0.23420554399490356, 0.11489367485046387, 0.002086441032588482, -0.27147266268730164, 0.8099349737167358, 0.41578248143196106, -0.13269680738449097, -0.28896892070770264, -0.018079886212944984, 0.3426474332809448, 0.4817587733268738, 0.017912518233060837, 0.24782167375087738, -0.13582253456115723, 0.16903044283390045, 0.29947513341903687, -0.1508636325597763, -0.20413394272327423, 0.10742849856615067, 0.3388013541698456, 0.049442142248153687, -0.4979153871536255, -0.18936622142791748, 0.21512623131275177, 0.08467640727758408, -0.6972862482070923, 0.373244047164917, -0.7310261130332947, 0.1356583535671234, -0.257162868976593, -0.3785473704338074, -0.29359719157218933, -0.03858398646116257, 0.1764092743396759, -0.2461247444152832, -0.24448227882385254, -0.14261962473392487, -0.7302115559577942, 0.4369272291660309, 0.027607692405581474, 0.4275902509689331, 0.12411078810691833, 0.6100788712501526, 0.1883680522441864, 0.4203015863895416, -0.38402625918388367, 0.42848262190818787, 0.10314957797527313, 0.7571506500244141, 0.04772595316171646, 0.33472132682800293, 0.29258865118026733, -0.6227378845214844, 0.13504979014396667, 0.14186972379684448, 0.610223114490509, -0.0878770723938942, -0.46533700823783875, -0.10328024625778198, -0.757811963558197, 0.26599931716918945, 0.47300249338150024, -0.2959226071834564, 0.16467031836509705, 0.04973458871245384, -0.41598859429359436, -0.37257805466651917, 0.05032911151647568, -0.3862864375114441, -0.27639052271842957, -0.6992011070251465, 0.02065172605216503, 0.19701401889324188, -0.47644150257110596, -0.0741368979215622, -0.41553163528442383, 0.08568039536476135, 0.18785035610198975, 0.6560625433921814, -0.44857001304626465, 0.018674064427614212, 0.5599818825721741, -0.29724013805389404, 0.252841055393219, -0.2745016813278198, -0.0843285322189331, 0.7717854380607605, -0.32938992977142334, 0.1042427197098732, 0.014010894112288952, -0.197283536195755, -0.1808430254459381, 0.28436484932899475, 0.6214082837104797, 0.028271310031414032, 0.27247974276542664, -0.19906389713287354, -0.6291307806968689, 0.03423214703798294, 0.5474991202354431, -0.4887528121471405, 0.3135955333709717, 0.26780790090560913, 0.21454240381717682, 0.22557783126831055, 0.2227359265089035, -0.2762058675289154, -0.37769559025764465, -0.359947144985199, 0.8799930810928345, -0.26924940943717957, 1.3524225950241089, -0.12233133614063263, 0.03573032468557358, 1.1069579124450684, 0.18589039146900177, 0.09463461488485336, 0.13858793675899506, -0.10411670058965683, 0.715901792049408, 0.03300788626074791, -0.41887012124061584, 0.004248423036187887, -0.01493101753294468, -0.09021410346031189, -0.007570426445454359, -0.29499974846839905, 0.4571729898452759, -0.2657827138900757, -0.42033693194389343, 0.15220360457897186, 0.10984847694635391, 0.20415443181991577, 0.07712995260953903, 0.2309604436159134, 0.19699327647686005, -0.461232453584671, 0.20834416151046753, -0.9277558326721191, 0.23194190859794617, -0.15099671483039856, -0.043428730219602585, 0.9670230150222778, 0.27124878764152527, -0.12944774329662323, 0.6945386528968811, -0.053800251334905624, 0.005977285094559193, 0.09699615836143494, 0.10233504325151443, -0.06762894988059998, 0.008945873938500881, 0.3226756155490875, -0.09027472883462906, -0.2699766159057617, -0.04902297630906105, -0.0085294209420681, 0.029562942683696747, -0.10133164376020432, -0.6421957015991211, -0.15476292371749878, -0.09727009385824203, -0.4421582818031311, -0.02940618060529232, -0.15948021411895752, -0.6120189428329468, 0.5167887806892395, -0.23349270224571228, 0.13419824838638306, 0.043136030435562134, -0.000289223127765581, -0.12977980077266693, 0.08919333666563034, 0.032159473747015, -0.5744391679763794, 0.6449757814407349, -0.46921566128730774, 0.16214619576931, 0.17493881285190582, 0.29461225867271423, -0.01898735947906971, -0.21754004061222076, -0.4278731644153595, -0.28923746943473816, -0.06296639144420624, 0.903616726398468, 0.37729859352111816, 0.33056244254112244, 0.2502511441707611, -0.9320644736289978, 0.27351489663124084, -0.002853269223123789, -0.6855313181877136, 0.05471274256706238, 0.6664773225784302, -0.79056715965271, -0.6183851957321167, -0.08249462395906448, 0.35697147250175476, 0.8358668088912964, -0.4964791536331177, -0.050566863268613815, -0.2900996506214142, -0.3037068247795105, -0.06154429167509079, -0.2568338215351105, -0.46664732694625854, -0.5714419484138489, 0.4078911542892456, -0.30129820108413696, -0.3449442684650421, 0.30897611379623413, 0.561840295791626, -0.2436089813709259, 0.316697895526886, 0.6922771334648132, 0.010694059543311596, 0.14907480776309967, 0.2287716418504715, 0.1836714744567871, -0.3098903000354767, -0.546615481376648, 0.43083328008651733, -0.40164127945899963, -0.039353881031274796, -5.98471736907959, 0.6248188614845276, -0.2747265100479126, -0.9855648279190063, -0.1278517246246338, 0.18246999382972717, 0.8969610929489136, 0.12472641468048096, 0.4634799659252167, -0.062189389020204544, -0.1052558645606041, 0.3962220847606659, -0.3342583179473877, 0.17136482894420624, -0.03765782341361046, 0.10317966341972351, 0.05145509913563728, -0.25787556171417236, 0.26661965250968933, 0.5379363894462585, 0.4029133915901184, -0.25138014554977417, 0.0417606383562088, 0.06457605212926865, 0.13922201097011566, 0.7334624528884888, -0.9233877658843994, 0.1967899650335312, 0.0585879310965538, -0.5823273658752441, 0.17780067026615143, -0.4118820130825043, -0.2842268943786621, 0.06988475471735, -0.1023533046245575, 0.12741251289844513, 0.3718101978302002, 0.08840785175561905, 0.15029975771903992, -0.28936493396759033, 0.04575556516647339, 0.3956826627254486, -0.18507173657417297, -0.41469821333885193, 0.4043390154838562, 0.39454329013824463, -0.008066573180258274, 0.06810830533504486, -0.22367535531520844, 0.7718244791030884, 0.3482409119606018, -0.3029736578464508, -0.16146905720233917, 0.5249800086021423, 0.445457398891449, 0.22588545083999634, -0.32093918323516846, 0.24008382856845856, -0.30527862906455994, 0.3274981379508972, -0.0026162827853113413, 0.20911501348018646, -0.30695971846580505, -0.9298474192619324, -0.21514827013015747, -0.02659108117222786, -1.0985057353973389, 0.3222751319408417, 0.395530641078949, -0.12722566723823547, 0.21198895573616028, 0.4762513041496277, 0.15621934831142426, -0.5402690768241882, 0.4799891412258148, -0.5624724626541138, 0.006332852877676487, -0.3950701951980591, -0.25617966055870056, -0.1553294062614441, 0.01613766886293888, -0.08563622087240219, 0.6975356936454773, -0.11762784421443939, -0.2153635174036026, -0.006101344712078571, -0.19074279069900513, -0.09279641509056091, -0.37421196699142456, -0.12471763044595718, 0.3730636537075043, -0.30935904383659363, -0.2744961380958557, 0.508446991443634, 0.3708750307559967, 0.5276027917861938, 0.7985380291938782, 0.37369504570961, 0.5735123753547668, 0.3654264509677887, 0.44216588139533997, -0.6653217673301697, -0.23419465124607086, -0.8593988418579102, 0.05937597155570984, -0.20832009613513947, -0.7872021794319153, 0.036192432045936584, 0.6064050197601318, -0.5079021453857422, 0.2554594874382019, 0.11829762160778046, -0.5245150327682495, -0.26846322417259216, 0.7237223982810974, -0.2309200018644333, 0.18445047736167908, -0.26619985699653625, 0.286516934633255, -0.4625397324562073, 0.08554292470216751, 0.11526556313037872, -0.022928310558199883, 0.3659307360649109, 0.12472555786371231, -0.527079701423645, 0.038598909974098206, 0.4922330379486084, -0.9553324580192566, 0.32169753313064575, -0.007243070285767317, 0.3501835763454437, -0.17658022046089172, -0.28596940636634827, 0.16399972140789032, -0.25078529119491577, -1.0380308628082275, 0.20266132056713104, 0.3204176723957062, 0.44999778270721436, 0.014495383948087692, -0.029210569337010384, -0.6193169355392456, 0.00622944300994277, 0.2681310176849365, -0.11397983133792877, 0.07827164977788925, -0.2705582082271576, -0.1672837734222412, -0.2265511155128479, -0.004823852796107531, -0.506217896938324, 0.2551591694355011, 0.07830473780632019, -0.18606092035770416, 0.209956556558609, 0.2590492367744446, 0.11378975212574005, -0.44037720561027527, -0.7171025276184082, 0.23922008275985718, -0.03486673906445503, -0.7957775592803955, -0.07256847620010376, -0.3135533630847931, -0.7497472763061523, -0.04374666139483452, -0.33881959319114685, 0.44545790553092957, 0.15850378572940826, 0.003713880432769656, -0.46815556287765503, 0.04375293850898743, 0.012604602612555027, 0.33971866965293884, -0.12037144601345062, -0.26720768213272095, -0.20213454961776733, -0.4418880343437195, 0.3384779691696167, 0.08720003813505173, -0.3804827034473419, -0.20168954133987427, 0.053836505860090256, 0.8067482709884644, 0.8786103129386902, -0.17902036011219025, -0.056781936436891556, -0.38093310594558716, -0.2796519696712494, 0.2569461464881897, -0.5596160292625427, 0.12691037356853485, -0.15757746994495392, -0.12970228493213654, -0.14368562400341034, 0.06692394614219666, 0.4872722327709198, 0.02511334978044033, 0.16116459667682648, -0.5996968150138855, 0.439563512802124, -0.35948804020881653, 0.24590495228767395, 0.45987164974212646, -0.4268951714038849, 0.1210000291466713, -0.2823792099952698, -0.7054845094680786, -0.3673717677593231, 0.11298586428165436, -0.035603396594524384, -0.3309897780418396, 0.21890966594219208, -0.3608478605747223, 0.09352618455886841, 0.01621764525771141, -0.33839288353919983, -0.43027999997138977, 0.22465193271636963, 0.10730354487895966, -0.48447155952453613, -0.2267979234457016, 0.2715565264225006, -0.12257055193185806, 0.5831406116485596, -0.006284607108682394, -0.6139211654663086, 0.17044523358345032, 0.031645286828279495, -0.2649109363555908, -0.13425159454345703, 0.11874529719352722, 0.09069796651601791, -0.3650113046169281, 0.1562129706144333, -0.21291744709014893, -0.23048973083496094, 0.1809927225112915, 0.5263587236404419, 0.22443532943725586, 0.4199531674385071, -0.08282238990068436, -0.22253002226352692, -0.09106407314538956, -0.08802132308483124, 0.1067471131682396, -0.5012732148170471, -0.0662769302725792, 0.3548707365989685, 0.541146457195282, -0.6278858780860901, -0.0934283658862114, -0.20016799867153168, 0.3728658854961395, 0.2980961799621582, -0.6209129691123962, -0.7856798768043518, -0.47782886028289795, 0.39384064078330994, 0.08215151727199554, -0.40179163217544556, 0.18382658064365387, 0.06742104142904282, 0.4648607075214386, 0.21362632513046265, -0.09661033749580383, -0.16980625689029694, 0.22905555367469788, -0.4501340389251709, 0.054842930287122726, 0.07647351175546646, 0.6671561002731323, 0.3853342533111572, -0.13913172483444214, 0.34288448095321655, -0.4292750060558319, 0.22559979557991028, 0.0026248579379171133, 0.15365056693553925, -0.6181408166885376, -0.5831055045127869, -0.04992383345961571, -0.21358107030391693, 0.08756731450557709, -0.19194917380809784, 0.3181836009025574, 0.011967169120907784, -0.5993964076042175, -0.39142563939094543, -0.33450543880462646, 0.289631724357605, -0.7804893255233765, -0.2863873243331909, 0.33202072978019714, 0.15663522481918335, -0.19114701449871063, 0.6495904922485352, 0.23454922437667847, -0.292321115732193, -0.4583091139793396, 0.4786899983882904, 0.4425220191478729, -0.6659742593765259, 0.47973334789276123, 0.055995866656303406, -0.023674985393881798, -0.10643655061721802, -0.268256276845932, 0.12947504222393036, 0.0357382670044899, -0.04748576879501343, 0.14238014817237854, 0.47433406114578247, -0.7551748752593994, -0.23763874173164368, -0.35183849930763245, -0.3130473494529724, 0.6012234091758728, 0.308052659034729, 0.2113773226737976, 0.9600598812103271, 0.5540810823440552, 0.23375216126441956, -0.4191530644893646, 0.49780410528182983, 0.2716406583786011, 0.5454232096672058, -0.07384320348501205, 0.1605798751115799, 0.35856112837791443, 0.11509031057357788, 0.2906697988510132, 0.3278924226760864, 0.04188617318868637, -0.11924750357866287, 0.19506925344467163, -0.8727670907974243, -0.030698396265506744, 0.2832646071910858, 0.45688676834106445, 0.35855036973953247, 0.03598169982433319, -0.012257922440767288, 0.2606549859046936, 0.3077772259712219, 0.12114986777305603, -0.12199854850769043, 0.49294260144233704, 0.08136303722858429, -0.2613510191440582, -0.4794835150241852, -0.11540278047323227, 0.3089563548564911, -0.2537713944911957, 0.03312584012746811, 0.5400142073631287, -0.11550549417734146, -0.7714055776596069, 0.11334935575723648, -0.3339070975780487, 0.2469325065612793, -0.02909952960908413, 0.39217042922973633, -0.2161964327096939, -0.12961193919181824, 0.2842445373535156, 0.32621335983276367, 0.2609885632991791, -0.19093093276023865, 0.4422764778137207, 0.40406298637390137, -0.3926565647125244, 0.4643162786960602, 0.07035687565803528, -0.21927863359451294, 0.0674615204334259, 0.614942193031311, 0.037211984395980835, 0.08264356106519699, -0.21394005417823792, 0.2003113031387329, 0.3730926215648651, -0.47429555654525757, -0.2661149799823761, -0.510259747505188, -0.33789339661598206, 0.264449805021286, 0.686651885509491, -0.18871112167835236, 0.10646131634712219, -0.7451657056808472, 0.39458879828453064, 0.11824921518564224, -0.047072939574718475, -0.1443072259426117, 0.31742948293685913, 0.32283902168273926, 0.4978348910808563, 0.43895527720451355, -0.2815003991127014, -0.07389193028211594, -0.07892896980047226, 0.39867648482322693, -0.34284159541130066, 0.2932092547416687, -0.29365748167037964, -0.10052536427974701, -0.5771111249923706, -0.1653413325548172, 0.36935535073280334, 0.4186825454235077, -0.3943946361541748, 0.13761372864246368, -0.008377519436180592, -0.30647867918014526, 0.47543928027153015, 0.09450960904359818, -0.27267107367515564, -0.4963677227497101, -0.5504165291786194, -0.6469970345497131, 0.24146302044391632, -0.6413644552230835, -0.08804593980312347, -0.1332649290561676, 0.2658710181713104, 0.09041838347911835, 0.0006861994625069201, 0.24525991082191467, -0.29908856749534607, -0.08452437072992325, -0.45517367124557495, 0.19599303603172302, -0.3603525757789612, 0.38660097122192383, 0.24672149121761322, 0.28247061371803284, 0.10120764374732971, -0.6880174279212952, -0.4543450176715851, -0.5844411253929138, -0.6957165002822876, -0.06439527124166489, 0.2528822422027588, 0.5636560320854187, 0.04958372190594673, -0.2588179111480713, -0.6663148999214172, 0.2029503732919693, -0.49308738112449646, -0.5058123469352722, -0.07150373607873917, -0.05528997257351875, -0.3248153030872345, -0.37762972712516785, -0.09199187904596329, -0.5045560598373413, -0.3917982280254364, -0.13922053575515747 ]