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anti-cytokeratin14 ThermoFisherScientific
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Cat#MA5-11599;RRID:AB_10982092
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Elastase Sigma Cat#E1250
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pheatmap(version:1.0.12) N/A
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anti-cytokeratin10 Abcam
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anti-Loricrin Abcam
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anti-ACTA2 Zsbio
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anti-Ki67 Zsbio
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anti-Ki67 Abcam
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anti-PCNA ABclonal
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anti-Nitrotyrosine Millpore
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anti-CPD CosmoBio
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anti-Vimentin ABclonal
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anti-DCT Abcam
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anti-HES1 Abcam
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anti-b-tubulin SantaCruz
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anti-CD207 Abcam
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anti-COL17A1 Abcam
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anti-SOX9 R&D
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anti-MFAP5 Sigma
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anti-rabbitIgGAlexaFluor488 ThermoFisherScientific
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Cat#A21206; RRID:AB_2535792
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anti-mouseIgGAlexaFluor568
ThermoFisherScientific
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DeoxyribonucleaseI Worthington Cat#LS006333
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RBClysisbuffer BDBiosciences Cat#555899
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7-Amino-ActinomycinD(7-AAD) BDBiosciences Cat#559925
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Crystalviolet BiohaoBiotechnology,China Cat#0502
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Quercetinhydrate TCI Cat#P0042
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L-Ascorbicacid Sigma Cat#A4544-500G
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4%paraformaldehyde,PFA Dingguo,China Cat#AR-0211
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TritonX-100 Sigma-Aldrich Cat#T9284
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RNaseInhibitor ThermoFisherScientific Cat#AM2694
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Promega
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Superasin
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ggplot2(version:3.2.1) Wickhametal.,2016
https://ggplot2.tidyverse.org/
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GENIE3(version:1.6.0) Huynh-Thuetal.,2010
https://bioconductor.org/packages/release/bioc/html/ GENIE3.html
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Cytoscape(version:3.7.1) Shannonetal.,2003
https://cytoscape.org/
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CellPhoneDB(version:1.1.0) Vento-Tormoetal.,2018
https://github.com/Teichlab/cellphonedb
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HISAT2(version:2.1.0) Kimetal.,2015
https://ccb.jhu.edu/software/hisat2/index.shtml
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RcisTarget(version:1.4.0) Aibaretal.,2017
https://bioconductor.org/packages/release/bioc/ html/RcisTarget.html
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Loveetal.,2014
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DESeq2(version:1.2.4)
https://bioconductor.org/packages/release/bioc/ html/DESeq2.html
YAML Metadata Warning: empty or missing yaml metadata in repo card (https://huggingface.co/docs/hub/datasets-cards)

A Single-Cell Transcriptomic Atlas of Human Skin Aging

This dataset contains structured tables extracted from the supplementary materials of the publication:

"A single-cell transcriptomic atlas of human skin aging"
Cell Reports, 2020
DOI: 10.1016/j.celrep.2020.108132

The data has been processed from the publication PDF into a .parquet file to facilitate downstream analysis and integration into machine learning workflows.


📦 Dataset Description

The dataset includes multiple tables capturing aging-related transcriptomic changes in human skin tissue at the single-cell level. Tables were extracted using PDF parsing tools and contain gene expression summaries and annotations useful for skin biology and aging research.


🔧 Usage Instructions

To load the Parquet file in Python:

import pandas as pd

df = pd.read_parquet("skin_aging_data.parquet")
print(df.head())

🚀 Use Cases

  • Aging biomarker discovery in dermal and epidermal compartments
  • Training skin-specific biological age predictors
  • Integrating skin aging profiles with other tissue atlases
  • Cross-species comparison of skin aging signatures
  • Evaluation of anti-aging interventions at single-cell resolution

📖 Citation

If you use this dataset, please cite:

Xie, W., et al. A single-cell transcriptomic atlas of human skin aging. Cell Reports, 2020.
DOI: 10.1016/j.celrep.2020.108132


🙏 Acknowledgments

This dataset was curated and converted by Iris Lee for open access machine learning research in aging biology and skin regeneration.

Source publication by Xie et al. (2020) — Cell Reports.

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