Daily Papers

Unmanned aerial vehicle (UAV) based object detection is a critical but challenging task, when applied in dynamically changing scenarios with limited annotated training data. Layout-to-image generation approaches have proved effective in promoting detection accuracy by synthesizing labeled images based on diffusion models. However, they suffer from frequently producing artifacts, especially near layout boundaries of tiny objects, thus substantially limiting their performance. To address these issues, we propose UAVGen, a novel layout-to-image generation framework tailored for UAV-based object detection. Specifically, UAVGen designs a Visual Prototype Conditioned Diffusion Model (VPC-DM) that constructs representative instances for each class and integrates them into latent embeddings for high-fidelity object generation. Moreover, a Focal Region Enhanced Data Pipeline (FRE-DP) is introduced to emphasize object-concentrated foreground regions in synthesis, combined with a label refinement to correct missing, extra and misaligned generations. Extensive experimental results demonstrate that our method significantly outperforms state-of-the-art approaches, and consistently promotes accuracy when integrated with distinct detectors. The source code is available at https://github.com/Sirius-Li/UAVGen.

Diffusion models (DMs) have become the leading choice for generative tasks across diverse domains. However, their reliance on multiple sequential forward passes significantly limits real-time performance. Previous acceleration methods have primarily focused on reducing the number of sampling steps or reusing intermediate results, failing to leverage variations across spatial regions within the image due to the constraints of convolutional U-Net structures. By harnessing the flexibility of Diffusion Transformers (DiTs) in handling variable number of tokens, we introduce RAS, a novel, training-free sampling strategy that dynamically assigns different sampling ratios to regions within an image based on the focus of the DiT model. Our key observation is that during each sampling step, the model concentrates on semantically meaningful regions, and these areas of focus exhibit strong continuity across consecutive steps. Leveraging this insight, RAS updates only the regions currently in focus, while other regions are updated using cached noise from the previous step. The model's focus is determined based on the output from the preceding step, capitalizing on the temporal consistency we observed. We evaluate RAS on Stable Diffusion 3 and Lumina-Next-T2I, achieving speedups up to 2.36x and 2.51x, respectively, with minimal degradation in generation quality. Additionally, a user study reveals that RAS delivers comparable qualities under human evaluation while achieving a 1.6x speedup. Our approach makes a significant step towards more efficient diffusion transformers, enhancing their potential for real-time applications.

We propose focal modulation networks (FocalNets in short), where self-attention (SA) is completely replaced by a focal modulation mechanism for modeling token interactions in vision. Focal modulation comprises three components: (i) hierarchical contextualization, implemented using a stack of depth-wise convolutional layers, to encode visual contexts from short to long ranges, (ii) gated aggregation to selectively gather contexts for each query token based on its content, and (iii) element-wise modulation or affine transformation to inject the aggregated context into the query. Extensive experiments show FocalNets outperform the state-of-the-art SA counterparts (e.g., Swin and Focal Transformers) with similar computational costs on the tasks of image classification, object detection, and segmentation. Specifically, FocalNets with tiny and base size achieve 82.3% and 83.9% top-1 accuracy on ImageNet-1K. After pretrained on ImageNet-22K in 224 resolution, it attains 86.5% and 87.3% top-1 accuracy when finetuned with resolution 224 and 384, respectively. When transferred to downstream tasks, FocalNets exhibit clear superiority. For object detection with Mask R-CNN, FocalNet base trained with 1\times outperforms the Swin counterpart by 2.1 points and already surpasses Swin trained with 3\times schedule (49.0 v.s. 48.5). For semantic segmentation with UPerNet, FocalNet base at single-scale outperforms Swin by 2.4, and beats Swin at multi-scale (50.5 v.s. 49.7). Using large FocalNet and Mask2former, we achieve 58.5 mIoU for ADE20K semantic segmentation, and 57.9 PQ for COCO Panoptic Segmentation. Using huge FocalNet and DINO, we achieved 64.3 and 64.4 mAP on COCO minival and test-dev, respectively, establishing new SoTA on top of much larger attention-based models like Swinv2-G and BEIT-3. Code and checkpoints are available at https://github.com/microsoft/FocalNet.

Region-level captioning aims to generate natural language descriptions for specific image regions while highlighting their distinguishing features. However, existing methods struggle to produce unique captions across multi-granularity, limiting their real-world applicability. To address the need for detailed region-level understanding, we introduce URECA dataset, a large-scale dataset tailored for multi-granularity region captioning. Unlike prior datasets that focus primarily on salient objects, URECA dataset ensures a unique and consistent mapping between regions and captions by incorporating a diverse set of objects, parts, and background elements. Central to this is a stage-wise data curation pipeline, where each stage incrementally refines region selection and caption generation. By leveraging Multimodal Large Language Models (MLLMs) at each stage, our pipeline produces distinctive and contextually grounded captions with improved accuracy and semantic diversity. Building upon this dataset, we present URECA, a novel captioning model designed to effectively encode multi-granularity regions. URECA maintains essential spatial properties such as position and shape through simple yet impactful modifications to existing MLLMs, enabling fine-grained and semantically rich region descriptions. Our approach introduces dynamic mask modeling and a high-resolution mask encoder to enhance caption uniqueness. Experiments show that URECA achieves state-of-the-art performance on URECA dataset and generalizes well to existing region-level captioning benchmarks.

Visual understanding is inherently contextual -- what we focus on in an image depends on the task at hand. For instance, given an image of a person holding a bouquet of flowers, we may focus on either the person such as their clothing, or the type of flowers, depending on the context of interest. Yet, most existing image encoding paradigms represent an image as a fixed, generic feature vector, overlooking the potential needs of prioritizing varying visual information for different downstream use cases. In this work, we introduce FocalLens, a conditional visual encoding method that produces different representations for the same image based on the context of interest, expressed flexibly through natural language. We leverage vision instruction tuning data and contrastively finetune a pretrained vision encoder to take natural language instructions as additional inputs for producing conditional image representations. Extensive experiments validate that conditional image representation from FocalLens better pronounce the visual features of interest compared to generic features produced by standard vision encoders like CLIP. In addition, we show FocalLens further leads to performance improvements on a range of downstream tasks including image-image retrieval, image classification, and image-text retrieval, with an average gain of 5 and 10 points on the challenging SugarCrepe and MMVP-VLM benchmarks, respectively.

Vision language models (VLMs) have experienced rapid advancements through the integration of large language models (LLMs) with image-text pairs, yet they struggle with detailed regional visual understanding due to limited spatial awareness of the vision encoder, and the use of coarse-grained training data that lacks detailed, region-specific captions. To address this, we introduce RegionGPT (short as RGPT), a novel framework designed for complex region-level captioning and understanding. RGPT enhances the spatial awareness of regional representation with simple yet effective modifications to existing visual encoders in VLMs. We further improve performance on tasks requiring a specific output scope by integrating task-guided instruction prompts during both training and inference phases, while maintaining the model's versatility for general-purpose tasks. Additionally, we develop an automated region caption data generation pipeline, enriching the training set with detailed region-level captions. We demonstrate that a universal RGPT model can be effectively applied and significantly enhancing performance across a range of region-level tasks, including but not limited to complex region descriptions, reasoning, object classification, and referring expressions comprehension.

We tackle open-vocabulary 3D scene understanding by introducing a novel data generation pipeline and training framework. Our method addresses three critical requirements for effective training: precise 3D region segmentation, comprehensive textual descriptions, and sufficient dataset scale. By leveraging state-of-the-art open-vocabulary image segmentation models and region-aware Vision-Language Models, we develop an automatic pipeline that generates high-quality 3D mask-text pairs. Applying this pipeline to multiple 3D scene datasets, we create Mosaic3D-5.6M, a dataset of over 30K annotated scenes with 5.6M mask-text pairs, significantly larger than existing datasets. Building upon this data, we propose Mosaic3D, a foundation model combining a 3D encoder trained with contrastive learning and a lightweight mask decoder for open-vocabulary 3D semantic and instance segmentation. Our approach achieves state-of-the-art results on open-vocabulary 3D semantic and instance segmentation tasks including ScanNet200, Matterport3D, and ScanNet++, with ablation studies validating the effectiveness of our large-scale training data.

Efficient vision-language understanding of large Remote Sensing Images (RSIs) is meaningful but challenging. Current Large Vision-Language Models (LVLMs) typically employ limited pre-defined grids to process images, leading to information loss when handling gigapixel RSIs. Conversely, using unlimited grids significantly increases computational costs. To preserve image details while reducing computational complexity, we propose a text-guided token pruning method with Dynamic Image Pyramid (DIP) integration. Our method introduces: (i) a Region Focus Module (RFM) that leverages text-aware region localization capability to identify critical vision tokens, and (ii) a coarse-to-fine image tile selection and vision token pruning strategy based on DIP, which is guided by RFM outputs and avoids directly processing the entire large imagery. Additionally, existing benchmarks for evaluating LVLMs' perception ability on large RSI suffer from limited question diversity and constrained image sizes. We construct a new benchmark named LRS-VQA, which contains 7,333 QA pairs across 8 categories, with image length up to 27,328 pixels. Our method outperforms existing high-resolution strategies on four datasets using the same data. Moreover, compared to existing token reduction methods, our approach demonstrates higher efficiency under high-resolution settings. Dataset and code are in https://github.com/VisionXLab/LRS-VQA.

We introduce Medal S, a medical segmentation foundation model that supports native-resolution spatial and textual prompts within an end-to-end trainable framework. Unlike text-only methods lacking spatial awareness, Medal S achieves channel-wise alignment between volumetric prompts and text embeddings, mitigating inaccuracies from resolution mismatches. By preserving full 3D context, it efficiently processes multiple native-resolution masks in parallel, enhancing multi-class segmentation performance. A lightweight 3D convolutional module enables precise voxel-space refinement guided by both prompt types, supporting up to 243 classes across CT, MRI, PET, ultrasound, and microscopy modalities in the BiomedSegFM dataset. Medal S offers two prompting modes: a text-only mode, where model predictions serve as spatial prompts for self-refinement without human input, and a hybrid mode, incorporating manual annotations for enhanced flexibility. For 24-class segmentation, parallel spatial prompting reduces inference time by more than 90% compared to sequential prompting. We propose dynamic resampling to address target-patch ratio imbalance, extending SAT and nnU-Net for data augmentation. Furthermore, we develop optimized text preprocessing, a two-stage inference strategy, and post-processing techniques to improve memory efficiency, precision, and inference speed. On the five-modality average on the validation set, Medal S outperforms SAT with a DSC of 75.44 (vs. 69.83), NSD of 77.34 (vs. 71.06), F1 of 38.24 (vs. 24.88), and DSC TP of 65.46 (vs. 46.97). Medal S achieves excellent performance by harmonizing spatial precision with semantic textual guidance, demonstrating superior efficiency and accuracy in multi-class medical segmentation tasks compared to sequential prompt-based approaches. Medal S will be publicly available at https://github.com/yinghemedical/Medal-S.

Vision-language foundation models (VLMs) show promise for diverse imaging tasks but often underperform on medical benchmarks. Prior efforts to improve performance include model finetuning, which requires large domain-specific datasets and significant compute, or manual prompt engineering, which is hard to generalize and often inaccessible to medical institutions seeking to deploy these tools. These challenges motivate interest in approaches that draw on a model's embedded knowledge while abstracting away dependence on human-designed prompts to enable scalable, weight-agnostic performance improvements. To explore this, we adapt the Declarative Self-improving Python (DSPy) framework for structured automated prompt optimization in medical vision-language systems through a comprehensive, formal evaluation. We implement prompting pipelines for five medical imaging tasks across radiology, gastroenterology, and dermatology, evaluating 10 open-source VLMs with four prompt optimization techniques. Optimized pipelines achieved a median relative improvement of 53% over zero-shot prompting baselines, with the largest gains ranging from 300% to 3,400% on tasks where zero-shot performance is low. These results highlight the substantial potential of applying automated prompt optimization to medical AI systems, demonstrating significant gains for vision-based applications requiring accurate clinical image interpretation. By reducing dependence on prompt design to elicit intended outputs, these techniques allow clinicians to focus on patient care and clinical decision-making. Furthermore, our experiments offer scalability and preserve data privacy, demonstrating performance improvement on open-source VLMs. We publicly release our evaluation pipelines to support reproducible research on specialized medical tasks, available at https://github.com/DaneshjouLab/prompt-triage-lab.

Composed Image Retrieval (CIR) represents a novel retrieval paradigm that is capable of expressing users' intricate retrieval requirements flexibly. It enables the user to give a multimodal query, comprising a reference image and a modification text, and subsequently retrieve the target image. Notwithstanding the considerable advances made by prevailing methodologies, CIR remains in its nascent stages due to two limitations: 1) inhomogeneity between dominant and noisy portions in visual data is ignored, leading to query feature degradation, and 2) the priority of textual data in the image modification process is overlooked, which leads to a visual focus bias. To address these two limitations, this work presents a focus mapping-based feature extractor, which consists of two modules: dominant portion segmentation and dual focus mapping. It is designed to identify significant dominant portions in images and guide the extraction of visual and textual data features, thereby reducing the impact of noise interference. Subsequently, we propose a textually guided focus revision module, which can utilize the modification requirements implied in the text to perform adaptive focus revision on the reference image, thereby enhancing the perception of the modification focus on the composed features. The aforementioned modules collectively constitute the segmentatiOn-based Focus shiFt reviSion nETwork (OFFSET), and comprehensive experiments on four benchmark datasets substantiate the superiority of our proposed method. The codes and data are available on https://zivchen-ty.github.io/OFFSET.github.io/

The visual projector serves as an essential bridge between the visual encoder and the Large Language Model (LLM) in a Multimodal LLM (MLLM). Typically, MLLMs adopt a simple MLP to preserve all visual contexts via one-to-one transformation. However, the visual tokens are redundant and can be considerably increased when dealing with high-resolution images, impairing the efficiency of MLLMs significantly. Some recent works have introduced resampler or abstractor to reduce the number of resulting visual tokens. Unfortunately, they fail to capture finer details and undermine the visual reasoning capabilities of MLLMs. In this work, we propose a novel visual projector, which adopts a coarse-to-fine scheme to inject the enriched characteristics to generate the condensed visual tokens. In specific, we first interpolate the visual features as a low-resolution point query, providing the overall visual representation as the foundation. Then, we introduce a region-to-point injection module that utilizes high-resolution, multi-level region-based cues as fine-grained reference keys and values, allowing them to be fully absorbed within the corresponding local context region. This step effectively updates the coarse point query, transforming it into an enriched one for the subsequent LLM reasoning. Extensive experiments demonstrate that our approach compresses the visual tokens by 75%~89%, while achieves comparable or even better performance across diverse benchmarks with significantly higher efficiency. The source codes can be found at https://github.com/CircleRadon/TokenPacker.

Recently, many attempts have been made to construct a transformer base U-shaped architecture, and new methods have been proposed that outperformed CNN-based rivals. However, serious problems such as blockiness and cropped edges in predicted masks remain because of transformers' patch partitioning operations. In this work, we propose a new U-shaped architecture for medical image segmentation with the help of the newly introduced focal modulation mechanism. The proposed architecture has asymmetric depths for the encoder and decoder. Due to the ability of the focal module to aggregate local and global features, our model could simultaneously benefit the wide receptive field of transformers and local viewing of CNNs. This helps the proposed method balance the local and global feature usage to outperform one of the most powerful transformer-based U-shaped models called Swin-UNet. We achieved a 1.68% higher DICE score and a 0.89 better HD metric on the Synapse dataset. Also, with extremely limited data, we had a 4.25% higher DICE score on the NeoPolyp dataset. Our implementations are available at: https://github.com/givkashi/Focal-UNet

Vision-specific concepts such as "region" have played a key role in extending general machine learning frameworks to tasks like object detection. Given the success of region-based detectors for supervised learning and the progress of intra-image methods for contrastive learning, we explore the use of regions for reconstructive pre-training. Starting from Masked Autoencoding (MAE) both as a baseline and an inspiration, we propose a parallel pre-text task tailored to address the one-to-many mapping between images and regions. Since such regions can be generated in an unsupervised way, our approach (R-MAE) inherits the wide applicability from MAE, while being more "region-aware". We conduct thorough analyses during the development of R-MAE, and converge on a variant that is both effective and efficient (1.3% overhead over MAE). Moreover, it shows consistent quantitative improvements when generalized to various pre-training data and downstream detection and segmentation benchmarks. Finally, we provide extensive qualitative visualizations to enhance the understanding of R-MAE's behaviour and potential. Code will be made available at https://github.com/facebookresearch/r-mae.

Medical image analysis is critical yet challenged by the need of jointly segmenting organs or tissues, and numerous instances for anatomical structures and tumor microenvironment analysis. Existing studies typically formulated different segmentation tasks in isolation, which overlooks the fundamental interdependencies between these tasks, leading to suboptimal segmentation performance and insufficient medical image understanding. To address this issue, we propose a Co-Seg++ framework for versatile medical segmentation. Specifically, we introduce a novel co-segmentation paradigm, allowing semantic and instance segmentation tasks to mutually enhance each other. We first devise a spatio-temporal prompt encoder (STP-Encoder) to capture long-range spatial and temporal relationships between segmentation regions and image embeddings as prior spatial constraints. Moreover, we devise a multi-task collaborative decoder (MTC-Decoder) that leverages cross-guidance to strengthen the contextual consistency of both tasks, jointly computing semantic and instance segmentation masks. Extensive experiments on diverse CT and histopathology datasets demonstrate that the proposed Co-Seg++ outperforms state-of-the-arts in the semantic, instance, and panoptic segmentation of dental anatomical structures, histopathology tissues, and nuclei instances. The source code is available at https://github.com/xq141839/Co-Seg-Plus.

The recent release of RadGenome-Chest CT has significantly advanced CT-based report generation. However, existing methods primarily focus on global features, making it challenging to capture region-specific details, which may cause certain abnormalities to go unnoticed. To address this, we propose MedRegion-CT, a region-focused Multi-Modal Large Language Model (MLLM) framework, featuring three key innovations. First, we introduce Region Representative (R^2) Token Pooling, which utilizes a 2D-wise pretrained vision model to efficiently extract 3D CT features. This approach generates global tokens representing overall slice features and region tokens highlighting target areas, enabling the MLLM to process comprehensive information effectively. Second, a universal segmentation model generates pseudo-masks, which are then processed by a mask encoder to extract region-centric features. This allows the MLLM to focus on clinically relevant regions, using six predefined region masks. Third, we leverage segmentation results to extract patient-specific attributions, including organ size, diameter, and locations. These are converted into text prompts, enriching the MLLM's understanding of patient-specific contexts. To ensure rigorous evaluation, we conducted benchmark experiments on report generation using the RadGenome-Chest CT. MedRegion-CT achieved state-of-the-art performance, outperforming existing methods in natural language generation quality and clinical relevance while maintaining interpretability. The code for our framework is publicly available.

Recent advances in Vision Language Models (VLMs) and Vision Foundation Models (VFMs) have opened new opportunities for zero-shot text-guided segmentation of remote sensing imagery. However, most existing approaches still rely on additional trainable components, limiting their generalisation and practical applicability. In this work, we investigate to what extent text-based remote sensing segmentation can be achieved without additional training, by relying solely on existing foundation models. We propose a simple yet effective approach that integrates contrastive and generative VLMs with the Segment Anything Model (SAM), enabling a fully training-free or lightweight LoRA-tuned pipeline. Our contrastive approach employs CLIP as mask selector for SAM's grid-based proposals, achieving state-of-the-art open-vocabulary semantic segmentation (OVSS) in a completely zero-shot setting. In parallel, our generative approach enables reasoning and referring segmentation by generating click prompts for SAM using GPT-5 in a zero-shot setting and a LoRA-tuned Qwen-VL model, with the latter yielding the best results. Extensive experiments across 19 remote sensing benchmarks, including open-vocabulary, referring, and reasoning-based tasks, demonstrate the strong capabilities of our approach. Code will be released at https://github.com/josesosajs/trainfree-rs-segmentation.

In this paper, we introduce an underexplored problem in facial analysis: generating and recognizing multi-attribute natural language descriptions, containing facial action units (AUs), emotional states, and age estimation, for arbitrarily selected face regions (termed FaceFocalDesc). We argue that the system's ability to focus on individual facial areas leads to better understanding and control. To achieve this capability, we construct a new multi-attribute description dataset for arbitrarily selected face regions, providing rich region-level annotations and natural language descriptions. Further, we propose a fine-tuned vision-language model based on Qwen2.5-VL, called Focal-RegionFace for facial state analysis, which incrementally refines its focus on localized facial features through multiple progressively fine-tuning stages, resulting in interpretable age estimation, FAU and emotion detection. Experimental results show that Focal-RegionFace achieves the best performance on the new benchmark in terms of traditional and widely used metrics, as well as new proposed metrics. This fully verifies its effectiveness and versatility in fine-grained multi-attribute face region-focal analysis scenarios.

Remote sensing has become critical for understanding environmental dynamics, urban planning, and disaster management. However, traditional remote sensing workflows often rely on explicit segmentation or detection methods, which struggle to handle complex, implicit queries that require reasoning over spatial context, domain knowledge, and implicit user intent. Motivated by this, we introduce a new task, \ie, geospatial pixel reasoning, which allows implicit querying and reasoning and generates the mask of the target region. To advance this task, we construct and release the first large-scale benchmark dataset called EarthReason, which comprises 5,434 manually annotated image masks with over 30,000 implicit question-answer pairs. Moreover, we propose SegEarth-R1, a simple yet effective language-guided segmentation baseline that integrates a hierarchical visual encoder, a large language model (LLM) for instruction parsing, and a tailored mask generator for spatial correlation. The design of SegEarth-R1 incorporates domain-specific adaptations, including aggressive visual token compression to handle ultra-high-resolution remote sensing images, a description projection module to fuse language and multi-scale features, and a streamlined mask prediction pipeline that directly queries description embeddings. Extensive experiments demonstrate that SegEarth-R1 achieves state-of-the-art performance on both reasoning and referring segmentation tasks, significantly outperforming traditional and LLM-based segmentation methods. Our data and code will be released at https://github.com/earth-insights/SegEarth-R1.

In this work, we investigate extending the comprehension of Multi-modal Large Language Models (MLLMs) to regional objects. To this end, we propose to extract features corresponding to regional objects as soft prompts for LLM, which provides a straightforward and scalable approach and eliminates the need for LLM fine-tuning. To effectively extract regional features from regular image features and irregular point cloud features, we present a novel and unified position-assisted feature extraction module. Furthermore, training an MLLM from scratch is highly time-consuming. Thus, we propose incrementally extending existing pre-trained MLLMs to comprehend more modalities and the regional objects of those modalities. Specifically, we freeze the Q-Former from BLIP-2, an impressive MLLM, and optimize the modality-specific Lora parameters in Q-Former and LLM for each newly introduced modality. The freezing of the Q-Former eliminates the need for extensive pre-training on massive image-text data. The freezed Q-Former pre-trained from massive image-text data is also beneficial for the pre-training on image-region-text data. We name our framework RegionBLIP. We pre-train RegionBLIP on image-region-text, point-cloud-text, and point-cloud-region-text data. Experimental results verify that can preserve the image comprehension capability of BILP-2 and further gain a comprehension of the newly introduced point cloud modality and regional objects. The Data, Code, and Pre-trained models will be available at https://github.com/mightyzau/RegionBLIP.

Interactive image segmentation enables annotators to efficiently perform pixel-level annotation for segmentation tasks. However, the existing interactive segmentation pipeline suffers from inefficient computations of interactive models because of the following two issues. First, annotators' later click is based on models' feedback of annotators' former click. This serial interaction is unable to utilize model's parallelism capabilities. Second, in each interaction step, the model handles the invariant image along with the sparse variable clicks, resulting in a process that's highly repetitive and redundant. For efficient computations, we propose a method named InterFormer that follows a new pipeline to address these issues. InterFormer extracts and preprocesses the computationally time-consuming part i.e. image processing from the existing process. Specifically, InterFormer employs a large vision transformer (ViT) on high-performance devices to preprocess images in parallel, and then uses a lightweight module called interactive multi-head self attention (I-MSA) for interactive segmentation. Furthermore, the I-MSA module's deployment on low-power devices extends the practical application of interactive segmentation. The I-MSA module utilizes the preprocessed features to efficiently response to the annotator inputs in real-time. The experiments on several datasets demonstrate the effectiveness of InterFormer, which outperforms previous interactive segmentation models in terms of computational efficiency and segmentation quality, achieve real-time high-quality interactive segmentation on CPU-only devices. The code is available at https://github.com/YouHuang67/InterFormer.

Transformers have shown remarkable performance in 3D medical image segmentation, but their high computational requirements and need for large amounts of labeled data limit their applicability. To address these challenges, we consider two crucial aspects: model efficiency and data efficiency. Specifically, we propose Light-UNETR, a lightweight transformer designed to achieve model efficiency. Light-UNETR features a Lightweight Dimension Reductive Attention (LIDR) module, which reduces spatial and channel dimensions while capturing both global and local features via multi-branch attention. Additionally, we introduce a Compact Gated Linear Unit (CGLU) to selectively control channel interaction with minimal parameters. Furthermore, we introduce a Contextual Synergic Enhancement (CSE) learning strategy, which aims to boost the data efficiency of Transformers. It first leverages the extrinsic contextual information to support the learning of unlabeled data with Attention-Guided Replacement, then applies Spatial Masking Consistency that utilizes intrinsic contextual information to enhance the spatial context reasoning for unlabeled data. Extensive experiments on various benchmarks demonstrate the superiority of our approach in both performance and efficiency. For example, with only 10% labeled data on the Left Atrial Segmentation dataset, our method surpasses BCP by 1.43% Jaccard while drastically reducing the FLOPs by 90.8% and parameters by 85.8%. Code is released at https://github.com/CUHK-AIM-Group/Light-UNETR.

Accurate segmentation of regions of interest in biomedical images holds substantial value in image analysis. Although several foundation models for biomedical segmentation have currently achieved excellent performance on certain datasets, they typically demonstrate sub-optimal performance on unseen domain data. We owe the deficiency to lack of vision-language knowledge before segmentation. Multimodal Large Language Models (MLLMs) bring outstanding understanding and reasoning capabilities to multimodal tasks, which inspires us to leverage MLLMs to inject Vision-Language Knowledge (VLK), thereby enabling vision models to demonstrate superior generalization capabilities on cross-domain datasets. In this paper, we propose using MLLMs to guide SAM in learning microscopy crose-domain data, unifying Segment Anything in Microscopy, named uLLSAM. Specifically, we propose the Vision-Language Semantic Alignment (VLSA) module, which injects VLK into Segment Anything Model (SAM). We find that after SAM receives global VLK prompts, its performance improves significantly, but there are deficiencies in boundary contour perception. Therefore, we further propose Semantic Boundary Regularization (SBR) to prompt SAM. Our method achieves performance improvements of 7.71% in Dice and 12.10% in SA across 9 in-domain microscopy datasets, achieving state-of-the-art performance. Our method also demonstrates improvements of 6.79% in Dice and 10.08% in SA across 10 out-ofdomain datasets, exhibiting strong generalization capabilities. Code is available at https://github.com/ieellee/uLLSAM.

Semi-dense feature matching methods have shown strong performance in challenging scenarios. However, the existing pipeline relies on a global search across the entire feature map to establish coarse matches, limiting further improvements in accuracy and efficiency. Motivated by this limitation, we propose a novel pipeline, CasP, which leverages cascaded correspondence priors for guidance. Specifically, the matching stage is decomposed into two progressive phases, bridged by a region-based selective cross-attention mechanism designed to enhance feature discriminability. In the second phase, one-to-one matches are determined by restricting the search range to the one-to-many prior areas identified in the first phase. Additionally, this pipeline benefits from incorporating high-level features, which helps reduce the computational costs of low-level feature extraction. The acceleration gains of CasP increase with higher resolution, and our lite model achieves a speedup of sim2.2times at a resolution of 1152 compared to the most efficient method, ELoFTR. Furthermore, extensive experiments demonstrate its superiority in geometric estimation, particularly with impressive cross-domain generalization. These advantages highlight its potential for latency-sensitive and high-robustness applications, such as SLAM and UAV systems. Code is available at https://github.com/pq-chen/CasP.

Although LiDAR semantic segmentation advances rapidly, state-of-the-art methods often incorporate specifically designed inductive bias derived from benchmarks originating from mechanical spinning LiDAR. This can limit model generalizability to other kinds of LiDAR technologies and make hyperparameter tuning more complex. To tackle these issues, we propose a generalized framework to accommodate various types of LiDAR prevalent in the market by replacing window-attention with our sparse focal point modulation. Our SFPNet is capable of extracting multi-level contexts and dynamically aggregating them using a gate mechanism. By implementing a channel-wise information query, features that incorporate both local and global contexts are encoded. We also introduce a novel large-scale hybrid-solid LiDAR semantic segmentation dataset for robotic applications. SFPNet demonstrates competitive performance on conventional benchmarks derived from mechanical spinning LiDAR, while achieving state-of-the-art results on benchmark derived from solid-state LiDAR. Additionally, it outperforms existing methods on our novel dataset sourced from hybrid-solid LiDAR. Code and dataset are available at https://github.com/Cavendish518/SFPNet and https://www.semanticindustry.top.

Modern Referring Image Segmentation (RIS) systems generate multiple candidate masks per expression but rely on a simple heuristic--typically the argmax detection score--to select the final output. We identify query selection as a failure-case bottleneck: although heuristic selection succeeds on 82-93% of samples, the residual 7-18% of failures dominate the error budget, leaving a best-query selection gap of 3-11% mIoU. We introduce Venice-H1, a lightweight, backbone-decoupled post-hoc re-ranking module that encodes each candidate through multi-scale grid signatures--compact spatial descriptors pooled onto 4x4, 8x8, and 16x16 grids--and feeds them to a Transformer-based re-ranker with a Failure Gate (ROCAUC 0.78-0.82) that intervenes only when the default choice is likely suboptimal. Instantiated on DeRIS-L and DeRIS-B, Venice-H1 achieves delta_fail of +1.40 and +0.89 mIoU with strictly positive 95% CIs on all 16/16 (split, backbone) pairs and harmful-switch rates below 0.53%. Zero-shot transfer to medical referring segmentation (MS-CXR, M3D-RefSeg-2D) yields +1.16 and +0.51 mIoU without RIS-backbone fine-tuning. The module adds approximately 11.3M parameters and under 1 ms latency.

In whole slide images (WSIs) analysis, attention-based multi-instance learning (MIL) models are susceptible to spurious correlations and degrade under domain shift. These methods may assign high attention weights to non-tumor regions, such as staining biases or artifacts, leading to unreliable tumor region localization. In this paper, we revisit max-pooling-based MIL methods from a causal perspective. Under mild assumptions, our theoretical results demonstrate that max-pooling encourages the model to focus on causal factors while ignoring bias-related factors. Furthermore, we discover that existing max-pooling-based methods may overfit the training set through rote memorization of instance features and fail to learn meaningful patterns. To address these issues, we propose FocusMIL, which couples max-pooling with an instance-level variational information bottleneck (VIB) to learn compact, predictive latent representations, and employs a multi-bag mini-batch scheme to stabilize optimization. We conduct comprehensive experiments on three real-world datasets and one semi-synthetic dataset. The results show that, by capturing causal factors, FocusMIL exhibits significant advantages in out-of-distribution scenarios and instance-level tumor region localization tasks.

Accurately grounding regions of interest (ROIs) is critical for diagnosis and treatment planning in medical imaging. While multimodal large language models (MLLMs) combine visual perception with natural language, current medical-grounding pipelines still rely on supervised fine-tuning with explicit spatial hints, making them ill-equipped to handle the implicit queries common in clinical practice. This work makes three core contributions. We first define Unified Medical Reasoning Grounding (UMRG), a novel vision-language task that demands clinical reasoning and pixel-level grounding. Second, we release U-MRG-14K, a dataset of 14K samples featuring pixel-level masks alongside implicit clinical queries and reasoning traces, spanning 10 modalities, 15 super-categories, and 108 specific categories. Finally, we introduce MedReasoner, a modular framework that distinctly separates reasoning from segmentation: an MLLM reasoner is optimized with reinforcement learning, while a frozen segmentation expert converts spatial prompts into masks, with alignment achieved through format and accuracy rewards. MedReasoner achieves state-of-the-art performance on U-MRG-14K and demonstrates strong generalization to unseen clinical queries, underscoring the significant promise of reinforcement learning for interpretable medical grounding.

As the core building block of vision transformers, attention is a powerful tool to capture long-range dependency. However, such power comes at a cost: it incurs a huge computation burden and heavy memory footprint as pairwise token interaction across all spatial locations is computed. A series of works attempt to alleviate this problem by introducing handcrafted and content-agnostic sparsity into attention, such as restricting the attention operation to be inside local windows, axial stripes, or dilated windows. In contrast to these approaches, we propose a novel dynamic sparse attention via bi-level routing to enable a more flexible allocation of computations with content awareness. Specifically, for a query, irrelevant key-value pairs are first filtered out at a coarse region level, and then fine-grained token-to-token attention is applied in the union of remaining candidate regions (\ie, routed regions). We provide a simple yet effective implementation of the proposed bi-level routing attention, which utilizes the sparsity to save both computation and memory while involving only GPU-friendly dense matrix multiplications. Built with the proposed bi-level routing attention, a new general vision transformer, named BiFormer, is then presented. As BiFormer attends to a small subset of relevant tokens in a query adaptive manner without distraction from other irrelevant ones, it enjoys both good performance and high computational efficiency, especially in dense prediction tasks. Empirical results across several computer vision tasks such as image classification, object detection, and semantic segmentation verify the effectiveness of our design. Code is available at https://github.com/rayleizhu/BiFormer.

Foundation models are a strong trend in deep learning and computer vision. These models serve as a base for applications as they require minor or no further fine-tuning by developers to integrate into their applications. Foundation models for zero-shot object segmentation such as Segment Anything (SAM) output segmentation masks from images without any further object information. When they are followed in a pipeline by an object identification model, they can perform object detection without training. Here, we focus on training such an object identification model. A crucial practical aspect for an object identification model is to be flexible in input size. As object identification is an image retrieval problem, a suitable method should handle multi-query multi-gallery situations without constraining the number of input images (e.g. by having fixed-size aggregation layers). The key solution to train such a model is the centroid triplet loss (CTL), which aggregates image features to their centroids. CTL yields high accuracy, avoids misleading training signals and keeps the model input size flexible. In our experiments, we establish a new state of the art on the ArmBench object identification task, which shows general applicability of our model. We furthermore demonstrate an integrated unseen object detection pipeline on the challenging HOPE dataset, which requires fine-grained detection. There, our pipeline matches and surpasses related methods which have been trained on dataset-specific data.

Natural language often struggles to accurately associate positional and attribute information with multiple instances, which limits current text-based visual generation models to simpler compositions featuring only a few dominant instances. To address this limitation, this work enhances diffusion models by introducing regional instance control, where each instance is governed by a bounding box paired with a free-form caption. Previous methods in this area typically rely on implicit position encoding or explicit attention masks to separate regions of interest (ROIs), resulting in either inaccurate coordinate injection or large computational overhead. Inspired by ROI-Align in object detection, we introduce a complementary operation called ROI-Unpool. Together, ROI-Align and ROI-Unpool enable explicit, efficient, and accurate ROI manipulation on high-resolution feature maps for visual generation. Building on ROI-Unpool, we propose ROICtrl, an adapter for pretrained diffusion models that enables precise regional instance control. ROICtrl is compatible with community-finetuned diffusion models, as well as with existing spatial-based add-ons (\eg, ControlNet, T2I-Adapter) and embedding-based add-ons (\eg, IP-Adapter, ED-LoRA), extending their applications to multi-instance generation. Experiments show that ROICtrl achieves superior performance in regional instance control while significantly reducing computational costs.

Effectively grounding complex language to pixels in remote sensing (RS) images is a critical challenge for applications like disaster response and environmental monitoring. Current models can parse simple, single-target commands but fail when presented with complex geospatial scenarios, e.g., segmenting objects at various granularities, executing multi-target instructions, and interpreting implicit user intent. To drive progress against these failures, we present LaSeRS, the first large-scale dataset built for comprehensive training and evaluation across four critical dimensions of language-guided segmentation: hierarchical granularity, target multiplicity, reasoning requirements, and linguistic variability. By capturing these dimensions, LaSeRS moves beyond simple commands, providing a benchmark for complex geospatial reasoning. This addresses a critical gap: existing datasets oversimplify, leading to sensitivity-prone real-world models. We also propose SegEarth-R2, an MLLM architecture designed for comprehensive language-guided segmentation in RS, which directly confronts these challenges. The model's effectiveness stems from two key improvements: (1) a spatial attention supervision mechanism specifically handles the localization of small objects and their components, and (2) a flexible and efficient segmentation query mechanism that handles both single-target and multi-target scenarios. Experimental results demonstrate that our SegEarth-R2 achieves outstanding performance on LaSeRS and other benchmarks, establishing a powerful baseline for the next generation of geospatial segmentation. All data and code will be released at https://github.com/earth-insights/SegEarth-R2.

Multi-modal brain tumor segmentation is critical for clinical diagnosis, and it requires accurate identification of distinct internal anatomical subregions. While the recent prompt-based segmentation paradigms enable interactive experiences for clinicians, existing methods ignore cross-modal correlations and rely on labor-intensive category-specific prompts, limiting their applicability in real-world scenarios. To address these issues, we propose a MSM-Seg framework for multi-modal brain tumor segmentation. The MSM-Seg introduces a novel dual-memory segmentation paradigm that synergistically integrates multi-modal and inter-slice information with the efficient category-agnostic prompt for brain tumor understanding. To this end, we first devise a modality-and-slice memory attention (MSMA) to exploit the cross-modal and inter-slice relationships among the input scans. Then, we propose a multi-scale category-agnostic prompt encoder (MCP-Encoder) to provide tumor region guidance for decoding. Moreover, we devise a modality-adaptive fusion decoder (MF-Decoder) that leverages the complementary decoding information across different modalities to improve segmentation accuracy. Extensive experiments on different MRI datasets demonstrate that our MSM-Seg framework outperforms state-of-the-art methods in multi-modal metastases and glioma tumor segmentation. The code is available at https://github.com/xq141839/MSM-Seg.

Accurate and generalizable object segmentation in ultrasound imaging remains a significant challenge due to anatomical variability, diverse imaging protocols, and limited annotated data. In this study, we propose a prompt-driven vision-language model (VLM) that integrates Grounding DINO with SAM2 to enable object segmentation across multiple ultrasound organs. A total of 18 public ultrasound datasets, encompassing the breast, thyroid, liver, prostate, kidney, and paraspinal muscle, were utilized. These datasets were divided into 15 for fine-tuning and validation of Grounding DINO using Low Rank Adaptation (LoRA) to the ultrasound domain, and 3 were held out entirely for testing to evaluate performance in unseen distributions. Comprehensive experiments demonstrate that our approach outperforms state-of-the-art segmentation methods, including UniverSeg, MedSAM, MedCLIP-SAM, BiomedParse, and SAMUS on most seen datasets while maintaining strong performance on unseen datasets without additional fine-tuning. These results underscore the promise of VLMs in scalable and robust ultrasound image analysis, reducing dependence on large, organ-specific annotated datasets. We will publish our code on code.sonography.ai after acceptance.

Being able to understand the relations between the user and the surrounding environment is instrumental to assist users in a worksite. For instance, understanding which objects a user is interacting with from images and video collected through a wearable device can be useful to inform the worker on the usage of specific objects in order to improve productivity and prevent accidents. Despite modern vision systems can rely on advanced algorithms for object detection, semantic and panoptic segmentation, these methods still require large quantities of domain-specific labeled data, which can be difficult to obtain in industrial scenarios. Motivated by this observation, we propose a pipeline which allows to generate synthetic images from 3D models of real environments and real objects. The generated images are automatically labeled and hence effortless to obtain. Exploiting the proposed pipeline, we generate a dataset comprising synthetic images automatically labeled for panoptic segmentation. This set is complemented by a small number of manually labeled real images for fine-tuning. Experiments show that the use of synthetic images allows to drastically reduce the number of real images needed to obtain reasonable panoptic segmentation performance.

Referring Remote Sensing Image Segmentation provides a flexible and fine-grained framework for remote sensing scene analysis via vision-language collaborative interpretation. Current approaches predominantly utilize a three-stage pipeline encompassing dual-modal encoding, cross-modal interaction, and pixel decoding. These methods demonstrate significant limitations in managing complex semantic relationships and achieving precise cross-modal alignment, largely due to their coupled processing mechanism that conflates target localization with boundary delineation. This architectural coupling amplifies error propagation under semantic ambiguity while restricting model generalizability and interpretability. To address these issues, we propose RSRefSeg 2, a decoupling paradigm that reformulates the conventional workflow into a collaborative dual-stage framework: coarse localization followed by fine segmentation. RSRefSeg 2 integrates CLIP's cross-modal alignment strength with SAM's segmentation generalizability through strategic foundation model collaboration. Specifically, CLIP is employed as the dual-modal encoder to activate target features within its pre-aligned semantic space and generate localization prompts. To mitigate CLIP's misactivation challenges in multi-entity scenarios described by referring texts, a cascaded second-order prompter is devised, which enhances precision through implicit reasoning via decomposition of text embeddings into complementary semantic subspaces. These optimized semantic prompts subsequently direct the SAM to generate pixel-level refined masks, thereby completing the semantic transmission pipeline. Extensive experiments (RefSegRS, RRSIS-D, and RISBench) demonstrate that RSRefSeg 2 surpasses contemporary methods in segmentation accuracy (+~3% gIoU) and complex semantic interpretation. Code is available at: https://github.com/KyanChen/RSRefSeg2.

Transformer-based methods have demonstrated impressive results in medical image restoration, attributed to the multi-head self-attention (MSA) mechanism in the spatial dimension. However, the majority of existing Transformers conduct attention within fixed and coarsely partitioned regions (e.g. the entire image or fixed patches), resulting in interference from irrelevant regions and fragmentation of continuous image content. To overcome these challenges, we introduce a novel Region Attention Transformer (RAT) that utilizes a region-based multi-head self-attention mechanism (R-MSA). The R-MSA dynamically partitions the input image into non-overlapping semantic regions using the robust Segment Anything Model (SAM) and then performs self-attention within these regions. This region partitioning is more flexible and interpretable, ensuring that only pixels from similar semantic regions complement each other, thereby eliminating interference from irrelevant regions. Moreover, we introduce a focal region loss to guide our model to adaptively focus on recovering high-difficulty regions. Extensive experiments demonstrate the effectiveness of RAT in various medical image restoration tasks, including PET image synthesis, CT image denoising, and pathological image super-resolution. Code is available at https://github.com/Yaziwel/Region-Attention-Transformer-for-Medical-Image-Restoration.git{https://github.com/RAT}.

We aim to develop a robust yet flexible visual foundation model for Earth observation. It should possess strong capabilities in recognizing and localizing diverse visual targets while providing compatibility with various input-output interfaces required across different task scenarios. Current systems cannot meet these requirements, as they typically utilize task-specific architecture trained on narrow data domains with limited semantic coverage. Our study addresses these limitations from two aspects: data and modeling. We first introduce an automatic data engine that enjoys significantly better scalability compared to previous human annotation or rule-based approaches. It has enabled us to create the largest dataset of its kind to date, comprising 270K image-text-mask triplets covering an unprecedented range of diverse semantic categories and attribute specifications. Based on this data foundation, we further propose a task unification paradigm that centers around referring expression segmentation. It effectively handles a wide range of vision-centric perception tasks, including classification, detection, segmentation, grounding, etc, using a single model without any task-specific heads. Combining these innovations on data and modeling, we present RemoteSAM, a foundation model that establishes new SoTA on several earth observation perception benchmarks, outperforming other foundation models such as Falcon, GeoChat, and LHRS-Bot with significantly higher efficiency. Models and data are publicly available at https://github.com/1e12Leon/RemoteSAM.

In clinical radiology reports, doctors capture important information about the patient's health status. They convey their observations from raw medical imaging data about the inner structures of a patient. As such, formulating reports requires medical experts to possess wide-ranging knowledge about anatomical regions with their normal, healthy appearance as well as the ability to recognize abnormalities. This explicit grasp on both the patient's anatomy and their appearance is missing in current medical image-processing systems as annotations are especially difficult to gather. This renders the models to be narrow experts e.g. for identifying specific diseases. In this work, we recover this missing link by adding human anatomy into the mix and enable the association of content in medical reports to their occurrence in associated imagery (medical phrase grounding). To exploit anatomical structures in this scenario, we present a sophisticated automatic pipeline to gather and integrate human bodily structures from computed tomography datasets, which we incorporate in our PAXRay: A Projected dataset for the segmentation of Anatomical structures in X-Ray data. Our evaluation shows that methods that take advantage of anatomical information benefit heavily in visually grounding radiologists' findings, as our anatomical segmentations allow for up to absolute 50% better grounding results on the OpenI dataset as compared to commonly used region proposals. The PAXRay dataset is available at https://constantinseibold.github.io/paxray/.

Driven by the recent advances in deep learning methods and, in particular, by the development of modern self-supervised learning algorithms, increased interest and efforts have been devoted to build foundation models (FMs) for medical images. In this work, we present our scalable training pipeline for large pathology imaging data, and a comprehensive analysis of various hyperparameter choices and training techniques for building pathology FMs. We release and make publicly available the first batch of our pathology FMs (https://github.com/kaiko-ai/towards_large_pathology_fms) trained on open-access TCGA whole slide images, a commonly used collection of pathology images. The experimental evaluation shows that our models reach state-of-the-art performance on various patch-level downstream tasks, ranging from breast cancer subtyping to colorectal nuclear segmentation. Finally, to unify the evaluation approaches used in the field and to simplify future comparisons of different FMs, we present an open-source framework (https://github.com/kaiko-ai/eva) designed for the consistent evaluation of pathology FMs across various downstream tasks.

In recent years, there has been a growing trend in computer vision towards exploiting RAW sensor data, which preserves richer information compared to conventional low-bit RGB images. Early studies mainly focused on enhancing visual quality, while more recent efforts aim to leverage the abundant information in RAW data to improve the performance of visual perception tasks such as object detection and segmentation. However, existing approaches still face two key limitations: large-scale ISP networks impose heavy computational overhead, while methods based on tuning traditional ISP pipelines are restricted by limited representational capacity.To address these issues, we propose Task-Aware Image Signal Processing (TA-ISP), a compact RAW-to-RGB framework that produces task-oriented representations for pretrained vision models. Instead of heavy dense convolutional pipelines, TA-ISP predicts a small set of lightweight, multi-scale modulation operators that act at global, regional, and pixel scales to reshape image statistics across different spatial extents. This factorized control significantly expands the range of spatially varying transforms that can be represented while keeping memory usage, computation, and latency tightly constrained. Evaluated on several RAW-domain detection and segmentation benchmarks under both daytime and nighttime conditions, TA-ISP consistently improves downstream accuracy while markedly reducing parameter count and inference time, making it well suited for deployment on resource-constrained devices.

Referring Expression Segmentation (RES) aims to generate a segmentation mask for the object described by a given language expression. Existing classic RES datasets and methods commonly support single-target expressions only, i.e., one expression refers to one target object. Multi-target and no-target expressions are not considered. This limits the usage of RES in practice. In this paper, we introduce a new benchmark called Generalized Referring Expression Segmentation (GRES), which extends the classic RES to allow expressions to refer to an arbitrary number of target objects. Towards this, we construct the first large-scale GRES dataset called gRefCOCO that contains multi-target, no-target, and single-target expressions. GRES and gRefCOCO are designed to be well-compatible with RES, facilitating extensive experiments to study the performance gap of the existing RES methods on the GRES task. In the experimental study, we find that one of the big challenges of GRES is complex relationship modeling. Based on this, we propose a region-based GRES baseline ReLA that adaptively divides the image into regions with sub-instance clues, and explicitly models the region-region and region-language dependencies. The proposed approach ReLA achieves new state-of-the-art performance on the both newly proposed GRES and classic RES tasks. The proposed gRefCOCO dataset and method are available at https://henghuiding.github.io/GRES.

We study fine-grained referring image segmentation via a decoupled reason-then-segment pipeline. A vision-language model (VLM) receives an image and a natural-language query, reasons about the scene, and emits structured spatial prompts: a bounding box plus two interior keypoints for every referred instance. A frozen promptable segmenter (SAM 2) converts these prompts into high-quality masks. Within our GenSeg-R1 framework we finetune Qwen3-VL models (4B and 8B parameters) using Group Relative Policy Optimization (GRPO), requiring no supervised reasoning-chain annotations. On RefCOCOg validation our best model (GenSeg-R1-8B) achieves 0.7127 cIoU and 0.7382 mIoU, substantially outperforming the corresponding Qwen3-VL Instruct baselines (+15.3 and +21.9 points, respectively) and surpassing Seg-Zero-7B [3] by +3.3 cIoU under identical evaluation. We further introduce GenSeg-R1-G, a variant trained on GRefCOCO [9] with a SAM 2 in-the-loop reward that directly optimizes mask quality. On GRefCOCO validation GenSeg-R1-G achieves 76.69% target mIoU with 82.40% accuracy on negative (no-target) prompts, substantially outperforming Seg-R1-7B and Seg-Zero-7B, which lack no-target detection capability. On ReasonSeg test, GenSeg-R1-4B reaches 68.40% mIoU, surpassing Seg-Zero-7B by +7.0 and Seg-R1-7B by +10.7 points.

Medical image and video segmentation is a critical task for precision medicine, which has witnessed considerable progress in developing task or modality-specific and generalist models for 2D images. However, there have been limited studies on building general-purpose models for 3D images and videos with comprehensive user studies. Here, we present MedSAM2, a promptable segmentation foundation model for 3D image and video segmentation. The model is developed by fine-tuning the Segment Anything Model 2 on a large medical dataset with over 455,000 3D image-mask pairs and 76,000 frames, outperforming previous models across a wide range of organs, lesions, and imaging modalities. Furthermore, we implement a human-in-the-loop pipeline to facilitate the creation of large-scale datasets resulting in, to the best of our knowledge, the most extensive user study to date, involving the annotation of 5,000 CT lesions, 3,984 liver MRI lesions, and 251,550 echocardiogram video frames, demonstrating that MedSAM2 can reduce manual costs by more than 85%. MedSAM2 is also integrated into widely used platforms with user-friendly interfaces for local and cloud deployment, making it a practical tool for supporting efficient, scalable, and high-quality segmentation in both research and healthcare environments.

The precise segmentation of retinal blood vessels is of great significance for early diagnosis of eye-related diseases such as diabetes and hypertension. In this work, we propose a lightweight network named Spatial Attention U-Net (SA-UNet) that does not require thousands of annotated training samples and can be utilized in a data augmentation manner to use the available annotated samples more efficiently. SA-UNet introduces a spatial attention module which infers the attention map along the spatial dimension, and multiplies the attention map by the input feature map for adaptive feature refinement. In addition, the proposed network employs structured dropout convolutional blocks instead of the original convolutional blocks of U-Net to prevent the network from overfitting. We evaluate SA-UNet based on two benchmark retinal datasets: the Vascular Extraction (DRIVE) dataset and the Child Heart and Health Study (CHASE_DB1) dataset. The results show that the proposed SA-UNet achieves state-of-the-art performance on both datasets.The implementation and the trained networks are available on Github1.

The advent of large pre-trained models has brought about a paradigm shift in both visual representation learning and natural language processing. However, clustering unlabeled images, as a fundamental and classic machine learning problem, still lacks an effective solution, particularly for large-scale datasets. In this paper, we propose a novel image clustering pipeline that leverages the powerful feature representation of large pre-trained models such as CLIP and cluster images effectively and efficiently at scale. We first developed a novel algorithm to estimate the number of clusters in a given dataset. We then show that the pre-trained features are significantly more structured by further optimizing the rate reduction objective. The resulting features may significantly improve the clustering accuracy, e.g., from 57% to 66% on ImageNet-1k. Furthermore, by leveraging CLIP's multimodality bridge between image and text, we develop a simple yet effective self-labeling algorithm that produces meaningful text labels for the clusters. Through extensive experiments, we show that our pipeline works well on standard datasets such as CIFAR-10, CIFAR-100, and ImageNet-1k. It also extends to datasets without predefined labels, such as LAION-Aesthetics and WikiArts. We released the code in https://github.com/LeslieTrue/CPP.

Recent advances in LVLMs have improved vision-language understanding, but they still struggle with spatial perception, limiting their ability to reason about complex 3D scenes. Unlike previous approaches that incorporate 3D representations into models to improve spatial understanding, we aim to unlock the potential of VLMs by leveraging spatially relevant image data. To this end, we introduce a novel 2D spatial data generation and annotation pipeline built upon scene data with 3D ground-truth. This pipeline enables the creation of a diverse set of spatial tasks, ranging from basic perception tasks to more complex reasoning tasks. Leveraging this pipeline, we construct SPAR-7M, a large-scale dataset generated from thousands of scenes across multiple public datasets. In addition, we introduce SPAR-Bench, a benchmark designed to offer a more comprehensive evaluation of spatial capabilities compared to existing spatial benchmarks, supporting both single-view and multi-view inputs. Training on both SPAR-7M and large-scale 2D datasets enables our models to achieve state-of-the-art performance on 2D spatial benchmarks. Further fine-tuning on 3D task-specific datasets yields competitive results, underscoring the effectiveness of our dataset in enhancing spatial reasoning.

Machine learning has celebrated a lot of achievements on computer vision tasks such as object detection, but the traditionally used models work with relatively low resolution images. The resolution of recording devices is gradually increasing and there is a rising need for new methods of processing high resolution data. We propose an attention pipeline method which uses two staged evaluation of each image or video frame under rough and refined resolution to limit the total number of necessary evaluations. For both stages, we make use of the fast object detection model YOLO v2. We have implemented our model in code, which distributes the work across GPUs. We maintain high accuracy while reaching the average performance of 3-6 fps on 4K video and 2 fps on 8K video.

The diffusion transformer (DiT) architecture has attracted significant attention in image generation, achieving better fidelity, performance, and diversity. However, most existing DiT - based image generation methods focus on global - aware synthesis, and regional prompt control has been less explored. In this paper, we propose a coarse - to - fine generation pipeline for regional prompt - following generation. Specifically, we first utilize the powerful large language model (LLM) to generate both high - level descriptions of the image (such as content, topic, and objects) and low - level descriptions (such as details and style). Then, we explore the influence of cross - attention layers at different depths. We find that deeper layers are always responsible for high - level content control, while shallow layers handle low - level content control. Various prompts are injected into the proposed regional cross - attention control for coarse - to - fine generation. By using the proposed pipeline, we enhance the controllability of DiT - based image generation. Extensive quantitative and qualitative results show that our pipeline can improve the performance of the generated images.

Pan-cancer screening in large-scale CT scans remains challenging for existing AI methods, primarily due to the difficulty of localizing diverse types of tiny lesions in large CT volumes. The extreme foreground-background imbalance significantly hinders models from focusing on diseased regions, while redundant focus on healthy regions not only decreases the efficiency but also increases false positives. Inspired by radiologists' glance and focus diagnostic strategy, we introduce GF-Screen, a Glance and Focus reinforcement learning framework for pan-cancer screening. GF-Screen employs a Glance model to localize the diseased regions and a Focus model to precisely segment the lesions, where segmentation results of the Focus model are leveraged to reward the Glance model via Reinforcement Learning (RL). Specifically, the Glance model crops a group of sub-volumes from the entire CT volume and learns to select the sub-volumes with lesions for the Focus model to segment. Given that the selecting operation is non-differentiable for segmentation training, we propose to employ the segmentation results to reward the Glance model. To optimize the Glance model, we introduce a novel group relative learning paradigm, which employs group relative comparison to prioritize high-advantage predictions and discard low-advantage predictions within sub-volume groups, not only improving efficiency but also reducing false positives. In this way, for the first time, we effectively extend cutting-edge RL techniques to tackle the specific challenges in pan-cancer screening. Extensive experiments on 16 internal and 7 external datasets across 9 lesion types demonstrated the effectiveness of GF-Screen. Notably, GF-Screen leads the public validation leaderboard of MICCAI FLARE25 pan-cancer challenge, surpassing the FLARE24 champion solution by a large margin (+25.6% DSC and +28.2% NSD).

Masked Image Modeling (MIM) has become an essential method for building foundational visual models in remote sensing (RS). However, the limitations in size and diversity of existing RS datasets restrict the ability of MIM methods to learn generalizable representations. Additionally, conventional MIM techniques, which require reconstructing all tokens, introduce unnecessary computational overhead. To address these issues, we present a new pre-training pipeline for RS models, featuring the creation of a large-scale RS dataset and an efficient MIM approach. We curated a high-quality dataset named OpticalRS-13M by collecting publicly available RS datasets and processing them through exclusion, slicing, and deduplication. OpticalRS-13M comprises 13 million optical images covering various RS tasks, such as object detection and pixel segmentation. To enhance efficiency, we propose SelectiveMAE, a pre-training method that dynamically encodes and reconstructs semantically rich patch tokens, thereby reducing the inefficiencies of traditional MIM models caused by redundant background pixels in RS images. Extensive experiments show that OpticalRS-13M significantly improves classification, detection, and segmentation performance, while SelectiveMAE increases training efficiency over 2times times. This highlights the effectiveness and scalability of our pipeline in developing RS foundational models. The dataset, source code, and trained models will be released at https://github.com/MiliLab/SelectiveMAE.

Efficiently quantifying renal structures can provide distinct spatial context and facilitate biomarker discovery for kidney morphology. However, the development and evaluation of the transformer model to segment the renal cortex, medulla, and collecting system remains challenging due to data inefficiency. Inspired by the hierarchical structures in vision transformer, we propose a novel method using a 3D block aggregation transformer for segmenting kidney components on contrast-enhanced CT scans. We construct the first cohort of renal substructures segmentation dataset with 116 subjects under institutional review board (IRB) approval. Our method yields the state-of-the-art performance (Dice of 0.8467) against the baseline approach of 0.8308 with the data-efficient design. The Pearson R achieves 0.9891 between the proposed method and manual standards and indicates the strong correlation and reproducibility for volumetric analysis. We extend the proposed method to the public KiTS dataset, the method leads to improved accuracy compared to transformer-based approaches. We show that the 3D block aggregation transformer can achieve local communication between sequence representations without modifying self-attention, and it can serve as an accurate and efficient quantification tool for characterizing renal structures.

Understanding the semantics of individual regions or patches within unconstrained images, such as in open-world object detection, represents a critical yet challenging task in computer vision. Building on the success of powerful image-level vision-language (ViL) foundation models like CLIP, recent efforts have sought to harness their capabilities by either training a contrastive model from scratch with an extensive collection of region-label pairs or aligning the outputs of a detection model with image-level representations of region proposals. Despite notable progress, these approaches are plagued by computationally intensive training requirements, susceptibility to data noise, and deficiency in contextual information. To address these limitations, we explore the synergistic potential of off-the-shelf foundation models, leveraging their respective strengths in localization and semantics. We introduce a novel, generic, and efficient region recognition architecture, named RegionSpot, designed to integrate position-aware localization knowledge from a localization foundation model (e.g., SAM) with semantic information extracted from a ViL model (e.g., CLIP). To fully exploit pretrained knowledge while minimizing training overhead, we keep both foundation models frozen, focusing optimization efforts solely on a lightweight attention-based knowledge integration module. Through extensive experiments in the context of open-world object recognition, our RegionSpot demonstrates significant performance improvements over prior alternatives, while also providing substantial computational savings. For instance, training our model with 3 million data in a single day using 8 V100 GPUs. Our model outperforms GLIP by 6.5 % in mean average precision (mAP), with an even larger margin by 14.8 % for more challenging and rare categories.

Recent advances in zero-shot referring image segmentation (RIS), driven by models such as the Segment Anything Model (SAM) and CLIP, have made substantial progress in aligning visual and textual information. Despite these successes, the extraction of precise and high-quality mask region representations remains a critical challenge, limiting the full potential of RIS tasks. In this paper, we introduce a training-free, hybrid global-local feature extraction approach that integrates detailed mask-specific features with contextual information from the surrounding area, enhancing mask region representation. To further strengthen alignment between mask regions and referring expressions, we propose a spatial guidance augmentation strategy that improves spatial coherence, which is essential for accurately localizing described areas. By incorporating multiple spatial cues, this approach facilitates more robust and precise referring segmentation. Extensive experiments on standard RIS benchmarks demonstrate that our method significantly outperforms existing zero-shot RIS models, achieving substantial performance gains. We believe our approach advances RIS tasks and establishes a versatile framework for region-text alignment, offering broader implications for cross-modal understanding and interaction. Code is available at https://github.com/fhgyuanshen/HybridGL .

We introduce Grounded SAM, which uses Grounding DINO as an open-set object detector to combine with the segment anything model (SAM). This integration enables the detection and segmentation of any regions based on arbitrary text inputs and opens a door to connecting various vision models. As shown in Fig.1, a wide range of vision tasks can be achieved by using the versatile Grounded SAM pipeline. For example, an automatic annotation pipeline based solely on input images can be realized by incorporating models such as BLIP and Recognize Anything. Additionally, incorporating Stable-Diffusion allows for controllable image editing, while the integration of OSX facilitates promptable 3D human motion analysis. Grounded SAM also shows superior performance on open-vocabulary benchmarks, achieving 48.7 mean AP on SegInW (Segmentation in the wild) zero-shot benchmark with the combination of Grounding DINO-Base and SAM-Huge models.

High-resolution image (HRI) understanding aims to process images with a large number of pixels, such as pathological images and agricultural aerial images, both of which can exceed 1 million pixels. Vision Large Language Models (VLMs) can allegedly handle HRIs, however, there is a lack of a comprehensive benchmark for VLMs to evaluate HRI understanding. To address this gap, we introduce HRScene, a novel unified benchmark for HRI understanding with rich scenes. HRScene incorporates 25 real-world datasets and 2 synthetic diagnostic datasets with resolutions ranging from 1,024 times 1,024 to 35,503 times 26,627. HRScene is collected and re-annotated by 10 graduate-level annotators, covering 25 scenarios, ranging from microscopic to radiology images, street views, long-range pictures, and telescope images. It includes HRIs of real-world objects, scanned documents, and composite multi-image. The two diagnostic evaluation datasets are synthesized by combining the target image with the gold answer and distracting images in different orders, assessing how well models utilize regions in HRI. We conduct extensive experiments involving 28 VLMs, including Gemini 2.0 Flash and GPT-4o. Experiments on HRScene show that current VLMs achieve an average accuracy of around 50% on real-world tasks, revealing significant gaps in HRI understanding. Results on synthetic datasets reveal that VLMs struggle to effectively utilize HRI regions, showing significant Regional Divergence and lost-in-middle, shedding light on future research.

Vision-language pre-training, i.e., aligning images with paired text, is a powerful paradigm to create encoders that can be directly used for tasks such as classification and retrieval, and for downstream tasks such as segmentation and report generation. In the 3D medical image domain, these capabilities allow vision-language encoders (VLEs) to support radiologists by retrieving patients with similar abnormalities or predicting likelihoods of abnormality. While the methodology holds promise, data availability limits the capabilities of current 3D VLEs. In this paper, we alleviate the lack of data by injecting additional inductive biases: introducing a report generation objective and pairing vision-language pre-training with vision-only pre-training. This allows us to leverage both image-only and paired image-text 3D datasets, increasing the total amount of data to which our model is exposed. Through these additional inductive biases, paired with best practices of the 3D medical imaging domain, we develop the Comprehensive Language-image Pre-training (COLIPRI) encoder family. Our COLIPRI encoders achieve state-of-the-art performance in report generation, classification probing, and zero-shot classification, and remain competitive for semantic segmentation.

Denoising diffusion models have enabled high-quality image generation and editing. We present a method to localize the desired edit region implicit in a text instruction. We leverage InstructPix2Pix (IP2P) and identify the discrepancy between IP2P predictions with and without the instruction. This discrepancy is referred to as the relevance map. The relevance map conveys the importance of changing each pixel to achieve the edits, and is used to to guide the modifications. This guidance ensures that the irrelevant pixels remain unchanged. Relevance maps are further used to enhance the quality of text-guided editing of 3D scenes in the form of neural radiance fields. A field is trained on relevance maps of training views, denoted as the relevance field, defining the 3D region within which modifications should be made. We perform iterative updates on the training views guided by rendered relevance maps from the relevance field. Our method achieves state-of-the-art performance on both image and NeRF editing tasks. Project page: https://ashmrz.github.io/WatchYourSteps/

We propose FocusCLIP, integrating subject-level guidance--a specialized mechanism for target-specific supervision--into the CLIP framework for improved zero-shot transfer on human-centric tasks. Our novel contributions enhance CLIP on both the vision and text sides. On the vision side, we incorporate ROI heatmaps emulating human visual attention mechanisms to emphasize subject-relevant image regions. On the text side, we introduce human pose descriptions to provide rich contextual information. For human-centric tasks, FocusCLIP is trained with images from the MPII Human Pose dataset. The proposed approach surpassed CLIP by an average of 8.61% across five previously unseen datasets covering three human-centric tasks. FocusCLIP achieved an average accuracy of 33.65% compared to 25.04% by CLIP. We observed a 3.98% improvement in activity recognition, a 14.78% improvement in age classification, and a 7.06% improvement in emotion recognition. Moreover, using our proposed single-shot LLM prompting strategy, we release a high-quality MPII Pose Descriptions dataset to encourage further research in multimodal learning for human-centric tasks. Furthermore, we also demonstrate the effectiveness of our subject-level supervision on non-human-centric tasks. FocusCLIP shows a 2.47% improvement over CLIP in zero-shot bird classification using the CUB dataset. Our findings emphasize the potential of integrating subject-level guidance with general pretraining methods for enhanced downstream performance.

Existing segmentation models based on multimodal large language models (MLLMs), such as LISA, often struggle with novel or emerging entities due to their inability to incorporate up-to-date knowledge. To address this challenge, we introduce the Novel Emerging Segmentation Task (NEST), which focuses on segmenting (i) novel entities that MLLMs fail to recognize due to their absence from training data, and (ii) emerging entities that exist within the model's knowledge but demand up-to-date external information for accurate recognition. To support the study of NEST, we construct a NEST benchmark using an automated pipeline that generates news-related data samples for comprehensive evaluation. Additionally, we propose ROSE: Retrieval-Oriented Segmentation Enhancement, a plug-and-play framework designed to augment any MLLM-based segmentation model. ROSE comprises four key components. First, an Internet Retrieval-Augmented Generation module is introduced to employ user-provided multimodal inputs to retrieve real-time web information. Then, a Textual Prompt Enhancer enriches the model with up-to-date information and rich background knowledge, improving the model's perception ability for emerging entities. Furthermore, a Visual Prompt Enhancer is proposed to compensate for MLLMs' lack of exposure to novel entities by leveraging internet-sourced images. To maintain efficiency, a WebSense module is introduced to intelligently decide when to invoke retrieval mechanisms based on user input. Experimental results demonstrate that ROSE significantly boosts performance on the NEST benchmark, outperforming a strong Gemini-2.0 Flash-based retrieval baseline by 19.2 in gIoU.

This paper introduces MedTrinity-25M, a comprehensive, large-scale multimodal dataset for medicine, covering over 25 million images across 10 modalities, with multigranular annotations for more than 65 diseases. These enriched annotations encompass both global textual information, such as disease/lesion type, modality, region-specific descriptions, and inter-regional relationships, as well as detailed local annotations for regions of interest (ROIs), including bounding boxes, segmentation masks. Unlike existing approach which is limited by the availability of image-text pairs, we have developed the first automated pipeline that scales up multimodal data by generating multigranular visual and texual annotations (in the form of image-ROI-description triplets) without the need for any paired text descriptions. Specifically, data from over 90 different sources have been collected, preprocessed, and grounded using domain-specific expert models to identify ROIs related to abnormal regions. We then build a comprehensive knowledge base and prompt multimodal large language models to perform retrieval-augmented generation with the identified ROIs as guidance, resulting in multigranular texual descriptions. Compared to existing datasets, MedTrinity-25M provides the most enriched annotations, supporting a comprehensive range of multimodal tasks such as captioning and report generation, as well as vision-centric tasks like classification and segmentation. Pretraining on MedTrinity-25M, our model achieves state-of-the-art performance on VQA-RAD and PathVQA, surpassing both multimodal large language models and other representative SoTA approaches. This dataset can also be utilized to support large-scale pre-training of multimodal medical AI models, contributing to the development of future foundation models in the medical domain.

Automated fetal head segmentation in ultrasound images is critical for accurate biometric measurements in prenatal care. While existing deep learning approaches have achieved a reasonable performance, they struggle with issues like low contrast, noise, and complex anatomical boundaries which are inherent to ultrasound imaging. This paper presents Attention-ResUNet. It is a novel architecture that synergistically combines residual learning with multi-scale attention mechanisms in order to achieve enhanced fetal head segmentation. Our approach integrates attention gates at four decoder levels to focus selectively on anatomically relevant regions while suppressing the background noise, and complemented by residual connections which facilitates gradient flow and feature reuse. Extensive evaluation on the HC18 Challenge dataset where n = 200 demonstrates that Attention ResUNet achieves a superior performance with a mean Dice score of 99.30 +/- 0.14% against similar architectures. It significantly outperforms five baseline architectures including ResUNet (99.26%), Attention U-Net (98.79%), Swin U-Net (98.60%), Standard U-Net (98.58%), and U-Net++ (97.46%). Through statistical analysis we confirm highly significant improvements (p < 0.001) with effect sizes that range from 0.230 to 13.159 (Cohen's d). Using Saliency map analysis, we reveal that our architecture produces highly concentrated, anatomically consistent activation patterns, which demonstrate an enhanced interpretability which is crucial for clinical deployment. The proposed method establishes a new state of the art performance for automated fetal head segmentation whilst maintaining computational efficiency with 14.7M parameters and a 45 GFLOPs inference cost. Code repository: https://github.com/Ammar-ss

We introduce Groma, a Multimodal Large Language Model (MLLM) with grounded and fine-grained visual perception ability. Beyond holistic image understanding, Groma is adept at region-level tasks such as region captioning and visual grounding. Such capabilities are built upon a localized visual tokenization mechanism, where an image input is decomposed into regions of interest and subsequently encoded into region tokens. By integrating region tokens into user instructions and model responses, we seamlessly enable Groma to understand user-specified region inputs and ground its textual output to images. Besides, to enhance the grounded chat ability of Groma, we curate a visually grounded instruction dataset by leveraging the powerful GPT-4V and visual prompting techniques. Compared with MLLMs that rely on the language model or external module for localization, Groma consistently demonstrates superior performances in standard referring and grounding benchmarks, highlighting the advantages of embedding localization into image tokenization. Project page: https://groma-mllm.github.io/.

With the emergence of LLMs and their integration with other data modalities, multi-modal 3D perception attracts more attention due to its connectivity to the physical world and makes rapid progress. However, limited by existing datasets, previous works mainly focus on understanding object properties or inter-object spatial relationships in a 3D scene. To tackle this problem, this paper builds the first largest ever multi-modal 3D scene dataset and benchmark with hierarchical grounded language annotations, MMScan. It is constructed based on a top-down logic, from region to object level, from a single target to inter-target relationships, covering holistic aspects of spatial and attribute understanding. The overall pipeline incorporates powerful VLMs via carefully designed prompts to initialize the annotations efficiently and further involve humans' correction in the loop to ensure the annotations are natural, correct, and comprehensive. Built upon existing 3D scanning data, the resulting multi-modal 3D dataset encompasses 1.4M meta-annotated captions on 109k objects and 7.7k regions as well as over 3.04M diverse samples for 3D visual grounding and question-answering benchmarks. We evaluate representative baselines on our benchmarks, analyze their capabilities in different aspects, and showcase the key problems to be addressed in the future. Furthermore, we use this high-quality dataset to train state-of-the-art 3D visual grounding and LLMs and obtain remarkable performance improvement both on existing benchmarks and in-the-wild evaluation. Codes, datasets, and benchmarks will be available at https://github.com/OpenRobotLab/EmbodiedScan.

The open-vocabulary image segmentation task involves partitioning images into semantically meaningful segments and classifying them with flexible text-defined categories. The recent vision-based foundation models such as the Segment Anything Model (SAM) have shown superior performance in generating class-agnostic image segments. The main challenge in open-vocabulary image segmentation now lies in accurately classifying these segments into text-defined categories. In this paper, we introduce the Universal Segment Embedding (USE) framework to address this challenge. This framework is comprised of two key components: 1) a data pipeline designed to efficiently curate a large amount of segment-text pairs at various granularities, and 2) a universal segment embedding model that enables precise segment classification into a vast range of text-defined categories. The USE model can not only help open-vocabulary image segmentation but also facilitate other downstream tasks (e.g., querying and ranking). Through comprehensive experimental studies on semantic segmentation and part segmentation benchmarks, we demonstrate that the USE framework outperforms state-of-the-art open-vocabulary segmentation methods.

Medical image segmentation allows quantifying target structure size and shape, aiding in disease diagnosis, prognosis, surgery planning, and comprehension.Building upon recent advancements in foundation Vision-Language Models (VLMs) from natural image-text pairs, several studies have proposed adapting them to Vision-Language Segmentation Models (VLSMs) that allow using language text as an additional input to segmentation models. Introducing auxiliary information via text with human-in-the-loop prompting during inference opens up unique opportunities, such as open vocabulary segmentation and potentially more robust segmentation models against out-of-distribution data. Although transfer learning from natural to medical images has been explored for image-only segmentation models, the joint representation of vision-language in segmentation problems remains underexplored. This study introduces the first systematic study on transferring VLSMs to 2D medical images, using carefully curated 11 datasets encompassing diverse modalities and insightful language prompts and experiments. Our findings demonstrate that although VLSMs show competitive performance compared to image-only models for segmentation after finetuning in limited medical image datasets, not all VLSMs utilize the additional information from language prompts, with image features playing a dominant role. While VLSMs exhibit enhanced performance in handling pooled datasets with diverse modalities and show potential robustness to domain shifts compared to conventional segmentation models, our results suggest that novel approaches are required to enable VLSMs to leverage the various auxiliary information available through language prompts. The code and datasets are available at https://github.com/naamiinepal/medvlsm.

Underwater exploration offers critical insights into our planet and attracts increasing attention for its broader applications in resource exploration, national security, etc. We study the underwater scene understanding methods, which aim to achieve automated underwater exploration. The underwater scene understanding task demands multi-task perceptions from multiple granularities. However, the absence of large-scale underwater multi-task instruction-tuning datasets hinders the progress of this research. To bridge this gap, we construct NautData, a dataset containing 1.45 M image-text pairs supporting eight underwater scene understanding tasks. It enables the development and thorough evaluation of the underwater scene understanding models. Underwater image degradation is a widely recognized challenge that interferes with underwater tasks. To improve the robustness of underwater scene understanding, we introduce physical priors derived from underwater imaging models and propose a plug-and-play vision feature enhancement (VFE) module, which explicitly restores clear underwater information. We integrate this module into renowned baselines LLaVA-1.5 and Qwen2.5-VL and build our underwater LMM, NAUTILUS. Experiments conducted on the NautData and public underwater datasets demonstrate the effectiveness of the VFE module, consistently improving the performance of both baselines on the majority of supported tasks, thus ensuring the superiority of NAUTILUS in the underwater scene understanding area. Data and models are available at https://github.com/H-EmbodVis/NAUTILUS.

In recent years, a standard computational pathology workflow has emerged where whole slide images are cropped into tiles, these tiles are processed using a foundation model, and task-specific models are built using the resulting representations. At least 15 different foundation models have been proposed, and the vast majority are trained exclusively with tiles using the 20times magnification. However, it is well known that certain histologic features can only be discerned with larger context windows and requires a pathologist to zoom in and out when analyzing a whole slide image. Furthermore, creating 224times224 pixel crops at 20times leads to a large number of tiles per slide, which can be gigapixel in size. To more accurately capture multi-resolution features and investigate the possibility of reducing the number of representations per slide, we propose a region-level mixing encoder. Our approach jointly fuses image tile representations of a mixed magnification foundation model using a masked embedding modeling pretraining step. We explore a design space for pretraining the proposed mixed-magnification region aggregators and evaluate our models on transfer to biomarker prediction tasks representing various cancer types. Results demonstrate cancer dependent improvements in predictive performance, highlighting the importance of spatial context and understanding.

The applicability of current lesion segmentation models for chest X-rays (CXRs) has been limited both by a small number of target labels and the reliance on long, detailed expert-level text inputs, creating a barrier to practical use. To address these limitations, we introduce a new paradigm: instruction-guided lesion segmentation (ILS), which is designed to segment diverse lesion types based on simple, user-friendly instructions. Under this paradigm, we construct MIMIC-ILS, the first large-scale instruction-answer dataset for CXR lesion segmentation, using our fully automated multimodal pipeline that generates annotations from chest X-ray images and their corresponding reports. MIMIC-ILS contains 1.1M instruction-answer pairs derived from 192K images and 91K unique segmentation masks, covering seven major lesion types. To empirically demonstrate its utility, we introduce ROSALIA, a vision-language model fine-tuned on MIMIC-ILS. ROSALIA can segment diverse lesions and provide textual explanations in response to user instructions. The model achieves high segmentation and textual accuracy in our newly proposed task, highlighting the effectiveness of our pipeline and the value of MIMIC-ILS as a foundational resource for pixel-level CXR lesion grounding.

Recently, instruction-based image editing (IIE) has received widespread attention. In practice, IIE often modifies only specific regions of an image, while the remaining areas largely remain unchanged. Although these two types of regions differ significantly in generation difficulty and computational redundancy, existing IIE models do not account for this distinction, instead applying a uniform generation process across the entire image. This motivates us to propose RegionE, an adaptive, region-aware generation framework that accelerates IIE tasks without additional training. Specifically, the RegionE framework consists of three main components: 1) Adaptive Region Partition. We observed that the trajectory of unedited regions is straight, allowing for multi-step denoised predictions to be inferred in a single step. Therefore, in the early denoising stages, we partition the image into edited and unedited regions based on the difference between the final estimated result and the reference image. 2) Region-Aware Generation. After distinguishing the regions, we replace multi-step denoising with one-step prediction for unedited areas. For edited regions, the trajectory is curved, requiring local iterative denoising. To improve the efficiency and quality of local iterative generation, we propose the Region-Instruction KV Cache, which reduces computational cost while incorporating global information. 3) Adaptive Velocity Decay Cache. Observing that adjacent timesteps in edited regions exhibit strong velocity similarity, we further propose an adaptive velocity decay cache to accelerate the local denoising process. We applied RegionE to state-of-the-art IIE base models, including Step1X-Edit, FLUX.1 Kontext, and Qwen-Image-Edit. RegionE achieved acceleration factors of 2.57, 2.41, and 2.06. Evaluations by GPT-4o confirmed that semantic and perceptual fidelity were well preserved.

Due to the inherent flexibility of prompting, foundation models have emerged as the predominant force in the fields of natural language processing and computer vision. The recent introduction of the Segment Anything Model (SAM) signifies a noteworthy expansion of the prompt-driven paradigm into the domain of image segmentation, thereby introducing a plethora of previously unexplored capabilities. However, the viability of its application to medical image segmentation remains uncertain, given the substantial distinctions between natural and medical images. In this work, we provide a comprehensive overview of recent endeavors aimed at extending the efficacy of SAM to medical image segmentation tasks, encompassing both empirical benchmarking and methodological adaptations. Additionally, we explore potential avenues for future research directions in SAM's role within medical image segmentation. While direct application of SAM to medical image segmentation does not yield satisfactory performance on multi-modal and multi-target medical datasets so far, numerous insights gleaned from these efforts serve as valuable guidance for shaping the trajectory of foundational models in the realm of medical image analysis. To support ongoing research endeavors, we maintain an active repository that contains an up-to-date paper list and a succinct summary of open-source projects at https://github.com/YichiZhang98/SAM4MIS.

Existing deep learning approaches leave out the semantic cues that are crucial in semantic segmentation present in complex scenarios including cluttered backgrounds and translucent objects, etc. To handle these challenges, we propose a feature amplification network (FANet) as a backbone network that incorporates semantic information using a novel feature enhancement module at multi-stages. To achieve this, we propose an adaptive feature enhancement (AFE) block that benefits from both a spatial context module (SCM) and a feature refinement module (FRM) in a parallel fashion. SCM aims to exploit larger kernel leverages for the increased receptive field to handle scale variations in the scene. Whereas our novel FRM is responsible for generating semantic cues that can capture both low-frequency and high-frequency regions for better segmentation tasks. We perform experiments over challenging real-world ZeroWaste-f dataset which contains background-cluttered and translucent objects. Our experimental results demonstrate the state-of-the-art performance compared to existing methods.

We present a unified, promptable model capable of simultaneously segmenting, recognizing, and captioning anything. Unlike SAM, we aim to build a versatile region representation in the wild via visual prompting. To achieve this, we train a generalizable model with massive segmentation masks, e.g., SA-1B masks, and semantic priors from a pre-trained CLIP model with 5 billion parameters. Specifically, we construct a promptable image decoder by adding a semantic token to each mask token. The semantic token is responsible for learning the semantic priors in a predefined concept space. Through joint optimization of segmentation on mask tokens and concept prediction on semantic tokens, our model exhibits strong regional recognition and localization capabilities. For example, an additional 38M-parameter causal text decoder trained from scratch sets a new record with a CIDEr score of 150.7 on the Visual Genome region captioning task. We believe this model can be a versatile region-level image tokenizer, capable of encoding general-purpose region context for a broad range of perception tasks. Code and models are available at https://github.com/baaivision/tokenize-anything.

Image-text retrieval has developed rapidly in recent years. However, it is still a challenge in remote sensing due to visual-semantic imbalance, which leads to incorrect matching of non-semantic visual and textual features. To solve this problem, we propose a novel Direction-Oriented Visual-semantic Embedding Model (DOVE) to mine the relationship between vision and language. Our highlight is to conduct visual and textual representations in latent space, directing them as close as possible to a redundancy-free regional visual representation. Concretely, a Regional-Oriented Attention Module (ROAM) adaptively adjusts the distance between the final visual and textual embeddings in the latent semantic space, oriented by regional visual features. Meanwhile, a lightweight Digging Text Genome Assistant (DTGA) is designed to expand the range of tractable textual representation and enhance global word-level semantic connections using less attention operations. Ultimately, we exploit a global visual-semantic constraint to reduce single visual dependency and serve as an external constraint for the final visual and textual representations. The effectiveness and superiority of our method are verified by extensive experiments including parameter evaluation, quantitative comparison, ablation studies and visual analysis, on two benchmark datasets, RSICD and RSITMD.

The remarkable capabilities of the Segment Anything Model (SAM) for tackling image segmentation tasks in an intuitive and interactive manner has sparked interest in the design of effective visual prompts. Such interest has led to the creation of automated point prompt selection strategies, typically motivated from a feature extraction perspective. However, there is still very little understanding of how appropriate these automated visual prompting strategies are, particularly when compared to humans, across diverse image domains. Additionally, the performance benefits of including such automated visual prompting strategies within the finetuning process of SAM also remains unexplored, as does the effect of interpretable factors like distance between the prompt points on segmentation performance. To bridge these gaps, we leverage a recently released visual prompting dataset, PointPrompt, and introduce a number of benchmarking tasks that provide an array of opportunities to improve the understanding of the way human prompts differ from automated ones and what underlying factors make for effective visual prompts. We demonstrate that the resulting segmentation scores obtained by humans are approximately 29% higher than those given by automated strategies and identify potential features that are indicative of prompting performance with R^2 scores over 0.5. Additionally, we demonstrate that performance when using automated methods can be improved by up to 68% via a finetuning approach. Overall, our experiments not only showcase the existing gap between human prompts and automated methods, but also highlight potential avenues through which this gap can be leveraged to improve effective visual prompt design. Further details along with the dataset links and codes are available at https://github.com/olivesgatech/PointPrompt

Medical image classification in radiology faces significant challenges, particularly in generalizing to unseen pathologies. In contrast, CLIP offers a promising solution by leveraging multimodal learning to improve zero-shot classification performance. However, in the medical domain, lesions can be small and might not be well represented in the embedding space. Therefore, in this paper, we explore the potential of visual prompt engineering to enhance the capabilities of Vision Language Models (VLMs) in radiology. Leveraging BiomedCLIP, trained on extensive biomedical image-text pairs, we investigate the impact of embedding visual markers directly within radiological images to guide the model's attention to critical regions. Our evaluation on the JSRT dataset, focusing on lung nodule malignancy classification, demonstrates that incorporating visual prompts x2013 such as arrows, circles, and contours x2013 significantly improves classification metrics including AUROC, AUPRC, F1 score, and accuracy. Moreover, the study provides attention maps, showcasing enhanced model interpretability and focus on clinically relevant areas. These findings underscore the efficacy of visual prompt engineering as a straightforward yet powerful approach to advance VLM performance in medical image analysis.

Nucleus segmentation is a challenging task due to the crowded distribution and blurry boundaries of nuclei. Recent approaches represent nuclei by means of polygons to differentiate between touching and overlapping nuclei and have accordingly achieved promising performance. Each polygon is represented by a set of centroid-to-boundary distances, which are in turn predicted by features of the centroid pixel for a single nucleus. However, using the centroid pixel alone does not provide sufficient contextual information for robust prediction and thus degrades the segmentation accuracy. To handle this problem, we propose a Context-aware Polygon Proposal Network (CPP-Net) for nucleus segmentation. First, we sample a point set rather than one single pixel within each cell for distance prediction. This strategy substantially enhances contextual information and thereby improves the robustness of the prediction. Second, we propose a Confidence-based Weighting Module, which adaptively fuses the predictions from the sampled point set. Third, we introduce a novel Shape-Aware Perceptual (SAP) loss that constrains the shape of the predicted polygons. Here, the SAP loss is based on an additional network that is pre-trained by means of mapping the centroid probability map and the pixel-to-boundary distance maps to a different nucleus representation. Extensive experiments justify the effectiveness of each component in the proposed CPP-Net. Finally, CPP-Net is found to achieve state-of-the-art performance on three publicly available databases, namely DSB2018, BBBC06, and PanNuke. Code of this paper is available at \url{https://github.com/csccsccsccsc/cpp-net

Semi-supervised learning (SSL) has emerged as an effective paradigm for medical image segmentation, reducing the reliance on extensive expert annotations. Meanwhile, vision-language models (VLMs) have demonstrated strong generalization and few-shot capabilities across diverse visual domains. In this work, we integrate VLM-based segmentation into semi-supervised medical image segmentation by introducing a Vision-Language Enhanced Semi-supervised Segmentation Assistant (VESSA) that incorporates foundation-level visual-semantic understanding into SSL frameworks. Our approach consists of two stages. In Stage 1, the VLM-enhanced segmentation foundation model VESSA is trained as a reference-guided segmentation assistant using a template bank containing gold-standard exemplars, simulating learning from limited labeled data. Given an input-template pair, VESSA performs visual feature matching to extract representative semantic and spatial cues from exemplar segmentations, generating structured prompts for a SAM2-inspired mask decoder to produce segmentation masks. In Stage 2, VESSA is integrated into a state-of-the-art SSL framework, enabling dynamic interaction with the student model: as student predictions become more refined, they are fed back to VESSA as prompts, allowing it to generate higher-quality pseudo-labels and stronger guidance. Extensive experiments across multiple segmentation datasets and domains show that VESSA-augmented SSL significantly enhances segmentation accuracy, outperforming state-of-the-art baselines under extremely limited annotation conditions.

Real-world medical image segmentation has tremendous long-tailed complexity of objects, among which tail conditions correlate with relatively rare diseases and are clinically significant. A trustworthy medical AI algorithm should demonstrate its effectiveness on tail conditions to avoid clinically dangerous damage in these out-of-distribution (OOD) cases. In this paper, we adopt the concept of object queries in Mask Transformers to formulate semantic segmentation as a soft cluster assignment. The queries fit the feature-level cluster centers of inliers during training. Therefore, when performing inference on a medical image in real-world scenarios, the similarity between pixels and the queries detects and localizes OOD regions. We term this OOD localization as MaxQuery. Furthermore, the foregrounds of real-world medical images, whether OOD objects or inliers, are lesions. The difference between them is less than that between the foreground and background, possibly misleading the object queries to focus redundantly on the background. Thus, we propose a query-distribution (QD) loss to enforce clear boundaries between segmentation targets and other regions at the query level, improving the inlier segmentation and OOD indication. Our proposed framework is tested on two real-world segmentation tasks, i.e., segmentation of pancreatic and liver tumors, outperforming previous state-of-the-art algorithms by an average of 7.39% on AUROC, 14.69% on AUPR, and 13.79% on FPR95 for OOD localization. On the other hand, our framework improves the performance of inlier segmentation by an average of 5.27% DSC when compared with the leading baseline nnUNet.

The scarcity of high-quality, labelled retinal imaging data, which presents a significant challenge in the development of machine learning models for ophthalmology, hinders progress in the field. Existing methods for synthesising Colour Fundus Photographs (CFPs) largely rely on predefined disease labels, which restricts their ability to generate images that reflect fine-grained anatomical variations, subtle disease stages, and diverse pathological features beyond coarse class categories. To overcome these challenges, we first introduce an innovative pipeline that creates a large-scale, captioned retinal dataset comprising 1.4 million entries, called RetinaLogos-1400k. Specifically, RetinaLogos-1400k uses the visual language model(VLM) to describe retinal conditions and key structures, such as optic disc configuration, vascular distribution, nerve fibre layers, and pathological features. Building on this dataset, we employ a novel three-step training framework, RetinaLogos, which enables fine-grained semantic control over retinal images and accurately captures different stages of disease progression, subtle anatomical variations, and specific lesion types. Through extensive experiments, our method demonstrates superior performance across multiple datasets, with 62.07% of text-driven synthetic CFPs indistinguishable from real ones by ophthalmologists. Moreover, the synthetic data improves accuracy by 5%-10% in diabetic retinopathy grading and glaucoma detection. Codes are available at https://github.com/uni-medical/retina-text2cfp.

Imaging under extremely low-light conditions presents a significant challenge and is an ill-posed problem due to the low signal-to-noise ratio (SNR) caused by minimal photon capture. Previously, diffusion models have been used for multiple kinds of generative tasks and image-to-image tasks, however, these models work as a post-processing step. These diffusion models are trained on processed images and learn on processed images. However, such approaches are often not well-suited for extremely low-light tasks. Unlike the task of low-light image enhancement or image-to-image enhancement, we tackle the task of learning the entire image-processing pipeline, from the RAW image to a processed image. For this task, a traditional image processing pipeline often consists of multiple specialized parts that are overly reliant on the downstream tasks. Unlike these, we develop a new generative ISP that relies on fine-tuning latent diffusion models on RAW images and generating processed long-exposure images which allows for the apt use of the priors from large text-to-image generation models. We evaluate our approach on popular end-to-end low-light datasets for which we see promising results and set a new SoTA on the See-in-Dark (SID) dataset. Furthermore, with this work, we hope to pave the way for more generative and diffusion-based image processing and other problems on RAW data.

Reliable end-to-end clinical report generation has been a longstanding goal of medical ML research. The end goal for this process is to alleviate radiologists' workloads and provide second opinions to clinicians or patients. Thus, a necessary prerequisite for report generation models is a strong general performance and some type of innate grounding capability, to convince clinicians or patients of the veracity of the generated reports. In this paper, we present ASaRG (Automatic Segmentation-assisted Report Generation), an extension of the popular LLaVA architecture that aims to tackle both of these problems. ASaRG proposes to fuse intermediate features and fine-grained segmentation maps created by specialist radiological models into LLaVA's multi-modal projection layer via simple concatenation. With a small number of added parameters, our approach achieves a +0.89\% performance gain (p=0.012) in CE F1 score compared to the LLaVA baseline when using only intermediate features, and +2.77\% performance gain (p<0.001) when adding a combination of intermediate features and fine-grained segmentation maps. Compared with COMG and ORID, two other report generation methods that utilize segmentations, the performance gain amounts to 6.98\% and 6.28\% in F1 score, respectively. ASaRG is not mutually exclusive with other changes made to the LLaVA architecture, potentially allowing our method to be combined with other advances in the field. Finally, the use of an arbitrary number of segmentations as part of the input demonstrably allows tracing elements of the report to the corresponding segmentation maps and verifying the groundedness of assessments. Our code will be made publicly available at a later date.

Accurate segmentation is essential for echocardiography-based assessment of cardiovascular diseases (CVDs). However, the variability among sonographers and the inherent challenges of ultrasound images hinder precise segmentation. By leveraging the joint representation of image and text modalities, Vision-Language Segmentation Models (VLSMs) can incorporate rich contextual information, potentially aiding in accurate and explainable segmentation. However, the lack of readily available data in echocardiography hampers the training of VLSMs. In this study, we explore using synthetic datasets from Semantic Diffusion Models (SDMs) to enhance VLSMs for echocardiography segmentation. We evaluate results for two popular VLSMs (CLIPSeg and CRIS) using seven different kinds of language prompts derived from several attributes, automatically extracted from echocardiography images, segmentation masks, and their metadata. Our results show improved metrics and faster convergence when pretraining VLSMs on SDM-generated synthetic images before finetuning on real images. The code, configs, and prompts are available at https://github.com/naamiinepal/synthetic-boost.

Open vocabulary image segmentation tackles the challenge of recognizing dynamically adjustable, predefined novel categories at inference time by leveraging vision-language alignment. However, existing paradigms typically perform class-agnostic region segmentation followed by category matching, which deviates from the human visual system's process of recognizing objects based on semantic concepts, leading to poor alignment between region segmentation and target concepts. To bridge this gap, we propose a novel Cognition-Inspired Framework for open vocabulary image segmentation that emulates the human visual recognition process: first forming a conceptual understanding of an object, then perceiving its spatial extent. The framework consists of three core components: (1) A Generative Vision-Language Model (G-VLM) that mimics human cognition by generating object concepts to provide semantic guidance for region segmentation. (2) A Concept-Aware Visual Enhancer Module that fuses textual concept features with global visual representations, enabling adaptive visual perception based on target concepts. (3) A Cognition-Inspired Decoder that integrates local instance features with G-VLM-provided semantic cues, allowing selective classification over a subset of relevant categories. Extensive experiments demonstrate that our framework achieves significant improvements, reaching 27.2 PQ, 17.0 mAP, and 35.3 mIoU on A-150. It further attains 56.2, 28.2, 15.4, 59.2, 18.7, and 95.8 mIoU on Cityscapes, Mapillary Vistas, A-847, PC-59, PC-459, and PAS-20, respectively. In addition, our framework supports vocabulary-free segmentation, offering enhanced flexibility in recognizing unseen categories. Code will be public.

Whilst the availability of 3D LiDAR point cloud data has significantly grown in recent years, annotation remains expensive and time-consuming, leading to a demand for semi-supervised semantic segmentation methods with application domains such as autonomous driving. Existing work very often employs relatively large segmentation backbone networks to improve segmentation accuracy, at the expense of computational costs. In addition, many use uniform sampling to reduce ground truth data requirements for learning needed, often resulting in sub-optimal performance. To address these issues, we propose a new pipeline that employs a smaller architecture, requiring fewer ground-truth annotations to achieve superior segmentation accuracy compared to contemporary approaches. This is facilitated via a novel Sparse Depthwise Separable Convolution module that significantly reduces the network parameter count while retaining overall task performance. To effectively sub-sample our training data, we propose a new Spatio-Temporal Redundant Frame Downsampling (ST-RFD) method that leverages knowledge of sensor motion within the environment to extract a more diverse subset of training data frame samples. To leverage the use of limited annotated data samples, we further propose a soft pseudo-label method informed by LiDAR reflectivity. Our method outperforms contemporary semi-supervised work in terms of mIoU, using less labeled data, on the SemanticKITTI (59.5@5%) and ScribbleKITTI (58.1@5%) benchmark datasets, based on a 2.3x reduction in model parameters and 641x fewer multiply-add operations whilst also demonstrating significant performance improvement on limited training data (i.e., Less is More).

With the increasing resolution of remote sensing imagery (RSI), large-size RSI has emerged as a vital data source for high-precision vector mapping of geographic objects. Existing methods are typically constrained to processing small image patches, which often leads to the loss of contextual information and produces fragmented vector outputs. To address these, this paper introduces HoliTracer, the first framework designed to holistically extract vectorized geographic objects from large-size RSI. In HoliTracer, we enhance segmentation of large-size RSI using the Context Attention Net (CAN), which employs a local-to-global attention mechanism to capture contextual dependencies. Furthermore, we achieve holistic vectorization through a robust pipeline that leverages the Mask Contour Reformer (MCR) to reconstruct polygons and the Polygon Sequence Tracer (PST) to trace vertices. Extensive experiments on large-size RSI datasets, including buildings, water bodies, and roads, demonstrate that HoliTracer outperforms state-of-the-art methods. Our code and data are available in https://github.com/vvangfaye/HoliTracer.

Adapting vision-language models to remote sensing imagery presents a fundamental challenge: both the visual and linguistic distributions of satellite data lie far outside natural image pretraining corpora. Despite this, prompting remains the dominant deployment paradigm, driven by the assumption that domain-specific language can guide frozen model representations toward specialized tasks. We test this assumption directly on a domain where the mismatch is prominent: cloud segmentation for satellite imagery. Using CLIPSeg on the CloudSEN12+ cloud segmentation benchmark, we evaluate 60 prompt variants spanning simple labels, domain terminology, appearance descriptors, and contextual cues, finding that every variant underperforms the zero-shot baseline (0.255 mIoU), with engineered prompts scoring as low as 0.07 mIoU. No amount of linguistic refinement bridges the gap between CLIP's natural image representations and satellite spectral imagery. In contrast, supervised fine-tuning with just 0.1% labeled data (~8 images) surpasses zero-shot performance overall, and 5-10% data recovers ~85% of maximum achievable mIoU. Full fine-tuning consistently outperforms low-rank adaptation by 0.03-0.09 mIoU, with the largest gaps for spectrally ambiguous classes, and at 0.5 to 1% labeled data, fine-tuning temporarily degrades performance on these classes before recovering, a supervision dip that aggregate mIoU can mask. For practitioners adapting vision-language models to specialized imagery, our results deliver a clear message: labeled data is not the expensive alternative to prompting; it is the worthwhile path.

We propose Uncertainty Augmented Context Attention network (UACANet) for polyp segmentation which consider a uncertain area of the saliency map. We construct a modified version of U-Net shape network with additional encoder and decoder and compute a saliency map in each bottom-up stream prediction module and propagate to the next prediction module. In each prediction module, previously predicted saliency map is utilized to compute foreground, background and uncertain area map and we aggregate the feature map with three area maps for each representation. Then we compute the relation between each representation and each pixel in the feature map. We conduct experiments on five popular polyp segmentation benchmarks, Kvasir, CVC-ClinicDB, ETIS, CVC-ColonDB and CVC-300, and achieve state-of-the-art performance. Especially, we achieve 76.6% mean Dice on ETIS dataset which is 13.8% improvement compared to the previous state-of-the-art method. Source code is publicly available at https://github.com/plemeri/UACANet

Finding scientifically interesting phenomena through slow, manual labeling campaigns severely limits our ability to explore the billions of galaxy images produced by telescopes. In this work, we develop a pipeline to create a semantic search engine from completely unlabeled image data. Our method leverages Vision-Language Models (VLMs) to generate descriptions for galaxy images, then contrastively aligns a pre-trained multimodal astronomy foundation model with these embedded descriptions to produce searchable embeddings at scale. We find that current VLMs provide descriptions that are sufficiently informative to train a semantic search model that outperforms direct image similarity search. Our model, AION-Search, achieves state-of-the-art zero-shot performance on finding rare phenomena despite training on randomly selected images with no deliberate curation for rare cases. Furthermore, we introduce a VLM-based re-ranking method that nearly doubles the recall for our most challenging targets in the top-100 results. For the first time, AION-Search enables flexible semantic search scalable to 140 million galaxy images, enabling discovery from previously infeasible searches. More broadly, our work provides an approach for making large, unlabeled scientific image archives semantically searchable, expanding data exploration capabilities in fields from Earth observation to microscopy. The code, data, and app are publicly available at https://github.com/NolanKoblischke/AION-Search

Referring Image Segmentation is a comprehensive task to segment an object referred by a textual query from an image. In nature, the level of difficulty in this task is affected by the existence of similar objects and the complexity of the referring expression. Recent RIS models still show a significant performance gap between easy and hard scenarios. We pose that the bottleneck exists in the data, and propose a simple but powerful data augmentation method, Negative-mined Mosaic Augmentation (NeMo). This method augments a training image into a mosaic with three other negative images carefully curated by a pretrained multimodal alignment model, e.g., CLIP, to make the sample more challenging. We discover that it is critical to properly adjust the difficulty level, neither too ambiguous nor too trivial. The augmented training data encourages the RIS model to recognize subtle differences and relationships between similar visual entities and to concretely understand the whole expression to locate the right target better. Our approach shows consistent improvements on various datasets and models, verified by extensive experiments.

We present SAM4EM, a novel approach for 3D segmentation of complex neural structures in electron microscopy (EM) data by leveraging the Segment Anything Model (SAM) alongside advanced fine-tuning strategies. Our contributions include the development of a prompt-free adapter for SAM using two stage mask decoding to automatically generate prompt embeddings, a dual-stage fine-tuning method based on Low-Rank Adaptation (LoRA) for enhancing segmentation with limited annotated data, and a 3D memory attention mechanism to ensure segmentation consistency across 3D stacks. We further release a unique benchmark dataset for the segmentation of astrocytic processes and synapses. We evaluated our method on challenging neuroscience segmentation benchmarks, specifically targeting mitochondria, glia, and synapses, with significant accuracy improvements over state-of-the-art (SOTA) methods, including recent SAM-based adapters developed for the medical domain and other vision transformer-based approaches. Experimental results indicate that our approach outperforms existing solutions in the segmentation of complex processes like glia and post-synaptic densities. Our code and models are available at https://github.com/Uzshah/SAM4EM.

Multimodal Large Language Models (MLLMs) require high-resolution visual information to perform fine-grained perception, yet processing entire high-resolution images is computationally prohibitive. While recent methods leverage a Region-of-Interest (RoI) mechanism to focus on salient areas, they typically present a difficult trade-off: training-based approaches depend on large-scale annotated datasets, while training-free methods that utilize the model's internal attention are computationally inefficient and less accurate, requiring either multi-pass prefill stages or reliance on the slow auto-regressive decoding process. In this paper, we propose an efficient, annotation-free Self-Distilled Region Proposal Network (SD-RPN) that resolves this trade-off. The SD-RPN is built around a pipeline that transforms the noisy attention maps from the MLLM's middle layers into high-quality pseudo-RoI labels by explicitly denoising the signal and resolving ambiguity. We use these labels to train a lightweight Region Proposal Network (RPN) that learns a more precise localization. This RPN is also highly efficient, predicting the RoI in a single forward pass using features from the MLLM's middle layers, decoupling RoI identification from the auto-regressive generation and avoiding costly multi-pass operations.To validate our approach, we integrate the framework into the LLaVA-1.5 architecture. Despite being trained on only a few (e.g. 10K) question-answer pairs, our method demonstrates exceptional data efficiency and generalization, achieving over a 10% absolute accuracy improvement on unseen benchmarks, including TextVQA, DocVQA, and V-Star. Our work presents a practical and scalable solution for enhancing the fine-grained perception of MLLMs without requiring costly supervision or full model fine-tuning. Code is available at https://github.com/YuHengsss/SD-RPN.

Diffusion models have emerged as dominant performers for image generation. To support training large diffusion models, this paper studies pipeline parallel training of diffusion models and proposes DiffusionPipe, a synchronous pipeline training system that advocates innovative pipeline bubble filling technique, catering to structural characteristics of diffusion models. State-of-the-art diffusion models typically include trainable (the backbone) and non-trainable (e.g., frozen input encoders) parts. We first unify optimal stage partitioning and pipeline scheduling of single and multiple backbones in representative diffusion models with a dynamic programming approach. We then propose to fill the computation of non-trainable model parts into idle periods of the pipeline training of the backbones by an efficient greedy algorithm, thus achieving high training throughput. Extensive experiments show that DiffusionPipe can achieve up to 1.41x speedup over pipeline parallel methods and 1.28x speedup over data parallel training on popular diffusion models.

Referring expression segmentation is a fundamental task in computer vision that integrates natural language understanding with precise visual localization of target regions. Considering aerial imagery (e.g., modern aerial photos collected through drones, historical photos from aerial archives, high-resolution satellite imagery, etc.) presents unique challenges because spatial resolution varies widely across datasets, the use of color is not consistent, targets often shrink to only a few pixels, and scenes contain very high object densities and objects with partial occlusions. This work presents Aerial-D, a new large-scale referring expression segmentation dataset for aerial imagery, comprising 37,288 images with 1,522,523 referring expressions that cover 259,709 annotated targets, spanning across individual object instances, groups of instances, and semantic regions covering 21 distinct classes that range from vehicles and infrastructure to land coverage types. The dataset was constructed through a fully automatic pipeline that combines systematic rule-based expression generation with a Large Language Model (LLM) enhancement procedure that enriched both the linguistic variety and the focus on visual details within the referring expressions. Filters were additionally used to simulate historic imaging conditions for each scene. We adopted the RSRefSeg architecture, and trained models on Aerial-D together with prior aerial datasets, yielding unified instance and semantic segmentation from text for both modern and historical images. Results show that the combined training achieves competitive performance on contemporary benchmarks, while maintaining strong accuracy under monochrome, sepia, and grainy degradations that appear in archival aerial photography. The dataset, trained models, and complete software pipeline are publicly available at https://luispl77.github.io/aerial-d .

Accurate semantic segmentation of terrestrial laser scanning (TLS) point clouds is limited by costly manual annotation. We propose a semi-automated, uncertainty-aware pipeline that integrates spherical projection, feature enrichment, ensemble learning, and targeted annotation to reduce labeling effort, while sustaining high accuracy. Our approach projects 3D points to a 2D spherical grid, enriches pixels with multi-source features, and trains an ensemble of segmentation networks to produce pseudo-labels and uncertainty maps, the latter guiding annotation of ambiguous regions. The 2D outputs are back-projected to 3D, yielding densely annotated point clouds supported by a three-tier visualization suite (2D feature maps, 3D colorized point clouds, and compact virtual spheres) for rapid triage and reviewer guidance. Using this pipeline, we build Mangrove3D, a semantic segmentation TLS dataset for mangrove forests. We further evaluate data efficiency and feature importance to address two key questions: (1) how much annotated data are needed and (2) which features matter most. Results show that performance saturates after ~12 annotated scans, geometric features contribute the most, and compact nine-channel stacks capture nearly all discriminative power, with the mean Intersection over Union (mIoU) plateauing at around 0.76. Finally, we confirm the generalization of our feature-enrichment strategy through cross-dataset tests on ForestSemantic and Semantic3D. Our contributions include: (i) a robust, uncertainty-aware TLS annotation pipeline with visualization tools; (ii) the Mangrove3D dataset; and (iii) empirical guidance on data efficiency and feature importance, thus enabling scalable, high-quality segmentation of TLS point clouds for ecological monitoring and beyond. The dataset and processing scripts are publicly available at https://fz-rit.github.io/through-the-lidars-eye/.

We present Singpath-VL, a vision-language large model, to fill the vacancy of AI assistant in cervical cytology. Recent advances in multi-modal large language models (MLLMs) have significantly propelled the field of computational pathology. However, their application in cytopathology, particularly cervical cytology, remains underexplored, primarily due to the scarcity of large-scale, high-quality annotated datasets. To bridge this gap, we first develop a novel three-stage pipeline to synthesize a million-scale image-description dataset. The pipeline leverages multiple general-purpose MLLMs as weak annotators, refines their outputs through consensus fusion and expert knowledge injection, and produces high-fidelity descriptions of cell morphology. Using this dataset, we then fine-tune the Qwen3-VL-4B model via a multi-stage strategy to create a specialized cytopathology MLLM. The resulting model, named Singpath-VL, demonstrates superior performance in fine-grained morphological perception and cell-level diagnostic classification. To advance the field, we will open-source a portion of the synthetic dataset and benchmark.

3D point clouds play a pivotal role in outdoor scene perception, especially in the context of autonomous driving. Recent advancements in 3D LiDAR segmentation often focus intensely on the spatial positioning and distribution of points for accurate segmentation. However, these methods, while robust in variable conditions, encounter challenges due to sole reliance on coordinates and point intensity, leading to poor isometric invariance and suboptimal segmentation. To tackle this challenge, our work introduces Range-Aware Pointwise Distance Distribution (RAPiD) features and the associated RAPiD-Seg architecture. Our RAPiD features exhibit rigid transformation invariance and effectively adapt to variations in point density, with a design focus on capturing the localized geometry of neighboring structures. They utilize inherent LiDAR isotropic radiation and semantic categorization for enhanced local representation and computational efficiency, while incorporating a 4D distance metric that integrates geometric and surface material reflectivity for improved semantic segmentation. To effectively embed high-dimensional RAPiD features, we propose a double-nested autoencoder structure with a novel class-aware embedding objective to encode high-dimensional features into manageable voxel-wise embeddings. Additionally, we propose RAPiD-Seg which incorporates a channel-wise attention fusion and two effective RAPiD-Seg variants, further optimizing the embedding for enhanced performance and generalization. Our method outperforms contemporary LiDAR segmentation work in terms of mIoU on SemanticKITTI (76.1) and nuScenes (83.6) datasets.

Instruction tuning large language model (LLM) on image-text pairs has achieved unprecedented vision-language multimodal abilities. However, their vision-language alignments are only built on image-level, the lack of region-level alignment limits their advancements to fine-grained multimodal understanding. In this paper, we propose instruction tuning on region-of-interest. The key design is to reformulate the bounding box as the format of spatial instruction. The interleaved sequences of visual features extracted by the spatial instruction and the language embedding are input to LLM, and trained on the transformed region-text data in instruction tuning format. Our region-level vision-language model, termed as GPT4RoI, brings brand new conversational and interactive experience beyond image-level understanding. (1) Controllability: Users can interact with our model by both language and spatial instructions to flexibly adjust the detail level of the question. (2) Capacities: Our model supports not only single-region spatial instruction but also multi-region. This unlocks more region-level multimodal capacities such as detailed region caption and complex region reasoning. (3) Composition: Any off-the-shelf object detector can be a spatial instruction provider so as to mine informative object attributes from our model, like color, shape, material, action, relation to other objects, etc. The code, data, and demo can be found at https://github.com/jshilong/GPT4RoI.

Language promptable X-ray image segmentation would enable greater flexibility for human-in-the-loop workflows in diagnostic and interventional precision medicine. Prior efforts have contributed task-specific models capable of solving problems within a narrow scope, but expanding to broader use requires additional data, annotations, and training time. Recently, language-aligned foundation models (LFMs) -- machine learning models trained on large amounts of highly variable image and text data thus enabling broad applicability -- have emerged as promising tools for automated image analysis. Existing foundation models for medical image analysis focus on scenarios and modalities where large, richly annotated datasets are available. However, the X-ray imaging modality features highly variable image appearance and applications, from diagnostic chest X-rays to interventional fluoroscopy, with varying availability of data. To pave the way toward an LFM for comprehensive and language-aligned analysis of arbitrary medical X-ray images, we introduce FluoroSAM, a language-promptable variant of the Segment Anything Model, trained from scratch on 3M synthetic X-ray images from a wide variety of human anatomies, imaging geometries, and viewing angles. These include pseudo-ground truth masks for 128 organ types and 464 tools with associated text descriptions. FluoroSAM is capable of segmenting myriad anatomical structures and tools based on natural language prompts, thanks to the novel incorporation of vector quantization (VQ) of text embeddings in the training process. We demonstrate FluoroSAM's performance quantitatively on real X-ray images and showcase on several applications how FluoroSAM is a key enabler for rich human-machine interaction in the X-ray image acquisition and analysis context. Code is available at https://github.com/arcadelab/fluorosam.

The integration of artificial intelligence (AI) with radiology marks a transformative era in medicine. Vision foundation models have been adopted to enhance radiologic imaging analysis. However, the distinct complexities of radiologic 2D and 3D radiologic data pose unique challenges that existing models, pre-trained on general non-medical images, fail to address adequately. To bridge this gap and capitalize on the diagnostic precision required in radiologic imaging, we introduce Radiologic Contrastive Language-Image Pre-training (RadCLIP): a cross-modal vision-language foundational model that harnesses Vision Language Pre-training (VLP) framework to improve radiologic image analysis. Building upon Contrastive Language-Image Pre-training (CLIP), RadCLIP incorporates a slice pooling mechanism tailored for volumetric image analysis and is pre-trained using a large and diverse dataset of radiologic image-text pairs. The RadCLIP was pre-trained to effectively align radiologic images with their corresponding text annotations, creating a robust vision backbone for radiologic images. Extensive experiments demonstrate RadCLIP's superior performance in both uni-modal radiologic image classification and cross-modal image-text matching, highlighting its significant promise for improving diagnostic accuracy and efficiency in clinical settings. Our Key contributions include curating a large dataset with diverse radiologic 2D/3D radiologic image-text pairs, a slice pooling adapter using an attention mechanism for integrating 2D images, and comprehensive evaluations of RadCLIP on various radiologic downstream tasks.

Vision-language models (VLMs) often generate massive visual tokens that greatly increase inference latency and memory footprint; while training-free token pruning offers a practical remedy, existing methods still struggle to balance local evidence and global context under aggressive compression. We propose Focus-Scan-Refine (FSR), a human-inspired, plug-and-play pruning framework that mimics how humans answer visual questions: focus on key evidence, then scan globally if needed, and refine the scanned context by aggregating relevant details. FSR first focuses on key evidence by combining visual importance with instruction relevance, avoiding the bias toward visually salient but query-irrelevant regions. It then scans for complementary context conditioned on the focused set, selecting tokens that are most different from the focused evidence. Finally, FSR refines the scanned context by aggregating nearby informative tokens into the scan anchors via similarity-based assignment and score-weighted merging, without increasing the token budget. Extensive experiments across multiple VLM backbones and vision-language benchmarks show that FSR consistently improves the accuracy-efficiency trade-off over existing state-of-the-art pruning methods. The source codes can be found at https://github.com/ILOT-code/FSR.

Precision medicine, such as patient-adaptive treatments assisted by medical image analysis, poses new challenges for segmentation algorithms in adapting to new patients, due to the large variability across different patients and the limited availability of annotated data for each patient. In this work, we propose a data-efficient segmentation algorithm, namely Part-aware Prompted Segment Anything Model (P^2SAM). Without any model fine-tuning, P^2SAM enables seamless adaptation to any new patients relying only on one-shot patient-specific data. We introduce a novel part-aware prompt mechanism to select multiple-point prompts based on the part-level features of the one-shot data, which can be extensively integrated into different promptable segmentation models, such as SAM and SAM 2. Moreover, to determine the optimal number of parts for each specific case, we propose a distribution-guided retrieval approach that further enhances the robustness of the part-aware prompt mechanism. P^2SAM improves the performance by +8.0% and +2.0% mean Dice score for two different patient-adaptive segmentation applications, respectively. In addition, P^2SAM also exhibits impressive generalizability in other adaptive segmentation tasks in the natural image domain, e.g., +6.4% mIoU within personalized object segmentation task. The code is available at: https://github.com/Zch0414/p2sam

Flowcharts are indispensable tools in software design and business-process analysis, yet current vision-language models (VLMs) frequently misinterpret the directional arrows and graph topology that set these diagrams apart from natural images. We introduce a seven-stage pipeline grouped into three broader processes: (1) arrow-aware detection of nodes and arrow endpoints; (2) optical character recognition (OCR) to extract node text; and (3) construction of a structured prompt that guides the VLMs. Tested on a 90-question benchmark distilled from 30 annotated flowcharts, the method raises overall accuracy from 80 % to 89 % (+9 percentage points) without any task-specific fine-tuning. The gain is most pronounced for next-step queries (25/30 -> 30/30; 100 %, +17 pp); branch-result questions improve more modestly, and before-step questions remain difficult. A parallel evaluation with an LLM-as-a-Judge protocol shows the same trends, reinforcing the advantage of explicit arrow encoding. Limitations include dependence on detector and OCR precision, the small evaluation set, and residual errors at nodes with multiple incoming edges. Future work will enlarge the benchmark with synthetic and handwritten flowcharts and assess the approach on Business Process Model and Notation (BPMN) and Unified Modeling Language (UML).

We present ENSAM (Equivariant, Normalized, Segment Anything Model), a lightweight and promptable model for universal 3D medical image segmentation. ENSAM combines a SegResNet-based encoder with a prompt encoder and mask decoder in a U-Net-style architecture, using latent cross-attention, relative positional encoding, normalized attention, and the Muon optimizer for training. ENSAM is designed to achieve good performance under limited data and computational budgets, and is trained from scratch on under 5,000 volumes from multiple modalities (CT, MRI, PET, ultrasound, microscopy) on a single 32 GB GPU in 6 hours. As part of the CVPR 2025 Foundation Models for Interactive 3D Biomedical Image Segmentation Challenge, ENSAM was evaluated on hidden test set with multimodal 3D medical images, obtaining a DSC AUC of 2.404, NSD AUC of 2.266, final DSC of 0.627, and final NSD of 0.597, outperforming two previously published baseline models (VISTA3D, SAM-Med3D) and matching the third (SegVol), surpassing its performance in final DSC but trailing behind in the other three metrics. In the coreset track of the challenge, ENSAM ranks 5th of 10 overall and best among the approaches not utilizing pretrained weights. Ablation studies confirm that our use of relative positional encodings and the Muon optimizer each substantially speed up convergence and improve segmentation quality.

The task of instance segmentation in remote sensing images, aiming at performing per-pixel labeling of objects at instance level, is of great importance for various civil applications. Despite previous successes, most existing instance segmentation methods designed for natural images encounter sharp performance degradations when they are directly applied to top-view remote sensing images. Through careful analysis, we observe that the challenges mainly come from the lack of discriminative object features due to severe scale variations, low contrasts, and clustered distributions. In order to address these problems, a novel context aggregation network (CATNet) is proposed to improve the feature extraction process. The proposed model exploits three lightweight plug-and-play modules, namely dense feature pyramid network (DenseFPN), spatial context pyramid (SCP), and hierarchical region of interest extractor (HRoIE), to aggregate global visual context at feature, spatial, and instance domains, respectively. DenseFPN is a multi-scale feature propagation module that establishes more flexible information flows by adopting inter-level residual connections, cross-level dense connections, and feature re-weighting strategy. Leveraging the attention mechanism, SCP further augments the features by aggregating global spatial context into local regions. For each instance, HRoIE adaptively generates RoI features for different downstream tasks. Extensive evaluations of the proposed scheme on iSAID, DIOR, NWPU VHR-10, and HRSID datasets demonstrate that the proposed approach outperforms state-of-the-arts under similar computational costs. Source code and pre-trained models are available at https://github.com/yeliudev/CATNet.

3D semantic segmentation is a fundamental task for robotic and autonomous driving applications. Recent works have been focused on using deep learning techniques, whereas developing fine-annotated 3D LiDAR datasets is extremely labor intensive and requires professional skills. The performance limitation caused by insufficient datasets is called data hunger problem. This research provides a comprehensive survey and experimental study on the question: are we hungry for 3D LiDAR data for semantic segmentation? The studies are conducted at three levels. First, a broad review to the main 3D LiDAR datasets is conducted, followed by a statistical analysis on three representative datasets to gain an in-depth view on the datasets' size and diversity, which are the critical factors in learning deep models. Second, a systematic review to the state-of-the-art 3D semantic segmentation is conducted, followed by experiments and cross examinations of three representative deep learning methods to find out how the size and diversity of the datasets affect deep models' performance. Finally, a systematic survey to the existing efforts to solve the data hunger problem is conducted on both methodological and dataset's viewpoints, followed by an insightful discussion of remaining problems and open questions To the best of our knowledge, this is the first work to analyze the data hunger problem for 3D semantic segmentation using deep learning techniques that are addressed in the literature review, statistical analysis, and cross-dataset and cross-algorithm experiments. We share findings and discussions, which may lead to potential topics in future works.

Referring Image Segmentation (RIS) is a challenging task that aims to segment objects in an image based on natural language expressions. While prior studies have predominantly concentrated on improving vision-language interactions and achieving fine-grained localization, a systematic analysis of the fundamental bottlenecks in existing RIS frameworks remains underexplored. To bridge this gap, we propose DeRIS, a novel framework that decomposes RIS into two key components: perception and cognition. This modular decomposition facilitates a systematic analysis of the primary bottlenecks impeding RIS performance. Our findings reveal that the predominant limitation lies not in perceptual deficiencies, but in the insufficient multi-modal cognitive capacity of current models. To mitigate this, we propose a Loopback Synergy mechanism, which enhances the synergy between the perception and cognition modules, thereby enabling precise segmentation while simultaneously improving robust image-text comprehension. Additionally, we analyze and introduce a simple non-referent sample conversion data augmentation to address the long-tail distribution issue related to target existence judgement in general scenarios. Notably, DeRIS demonstrates inherent adaptability to both non- and multi-referents scenarios without requiring specialized architectural modifications, enhancing its general applicability. The codes and models are available at https://github.com/Dmmm1997/DeRIS.

This report presents an overview of the AIM 2025 RipSeg Challenge, a competition designed to advance techniques for automatic rip current segmentation in still images. Rip currents are dangerous, fast-moving flows that pose a major risk to beach safety worldwide, making accurate visual detection an important and underexplored research task. The challenge builds on RipVIS, the largest available rip current dataset, and focuses on single-class instance segmentation, where precise delineation is critical to fully capture the extent of rip currents. The dataset spans diverse locations, rip current types, and camera orientations, providing a realistic and challenging benchmark. In total, 75 participants registered for this first edition, resulting in 5 valid test submissions. Teams were evaluated on a composite score combining F_1, F_2, AP_{50}, and AP_{[50:95]}, ensuring robust and application-relevant rankings. The top-performing methods leveraged deep learning architectures, domain adaptation techniques, pretrained models, and domain generalization strategies to improve performance under diverse conditions. This report outlines the dataset details, competition framework, evaluation metrics, and final results, providing insights into the current state of rip current segmentation. We conclude with a discussion of key challenges, lessons learned from the submissions, and future directions for expanding RipSeg.

Identifying potential objects is critical for object recognition and analysis across various computer vision applications. Existing methods typically localize potential objects by relying on exemplar images, predefined categories, or textual descriptions. However, their reliance on image and text prompts often limits flexibility, restricting adaptability in real-world scenarios. In this paper, we introduce a novel Prompt-Free Universal Region Proposal Network (PF-RPN), which identifies potential objects without relying on external prompts. First, the Sparse Image-Aware Adapter (SIA) module performs initial localization of potential objects using a learnable query embedding dynamically updated with visual features. Next, the Cascade Self-Prompt (CSP) module identifies the remaining potential objects by leveraging the self-prompted learnable embedding, autonomously aggregating informative visual features in a cascading manner. Finally, the Centerness-Guided Query Selection (CG-QS) module facilitates the selection of high-quality query embeddings using a centerness scoring network. Our method can be optimized with limited data (e.g., 5% of MS COCO data) and applied directly to various object detection application domains for identifying potential objects without fine-tuning, such as underwater object detection, industrial defect detection, and remote sensing image object detection. Experimental results across 19 datasets validate the effectiveness of our method. Code is available at https://github.com/tangqh03/PF-RPN.

We introduce eCLIP, an enhanced version of the CLIP model that integrates expert annotations in the form of radiologist eye-gaze heatmaps. It tackles key challenges in contrastive multi-modal medical imaging analysis, notably data scarcity and the "modality gap" -- a significant disparity between image and text embeddings that diminishes the quality of representations and hampers cross-modal interoperability. eCLIP integrates a heatmap processor and leverages mixup augmentation to efficiently utilize the scarce expert annotations, thus boosting the model's learning effectiveness. eCLIP is designed to be generally applicable to any variant of CLIP without requiring any modifications of the core architecture. Through detailed evaluations across several tasks, including zero-shot inference, linear probing, cross-modal retrieval, and Retrieval Augmented Generation (RAG) of radiology reports using a frozen Large Language Model, eCLIP showcases consistent improvements in embedding quality. The outcomes reveal enhanced alignment and uniformity, affirming eCLIP's capability to harness high-quality annotations for enriched multi-modal analysis in the medical imaging domain.

Impact craters are a cornerstone of planetary surface analysis. However, while most deep learning pipelines treat craters solely as a detection problem, critical scientific workflows such as catalog deduplication, cross-observation matching, and morphological analog discovery are inherently retrieval tasks. To address this, we formulate crater analysis as an instance-level image retrieval problem and introduce CraterBench-R, a curated benchmark featuring about 25,000 crater identities with multi-scale gallery views and manually verified queries spanning diverse scales and contexts. Our baseline evaluations across various architectures reveal that self-supervised Vision Transformers (ViTs), particularly those with in-domain pretraining, dominate the task, outperforming generic models with significantly more parameters. Furthermore, we demonstrate that retaining multiple ViT patch tokens for late-interaction matching dramatically improves accuracy over standard single-vector pooling. However, storing all tokens per image is operationally inefficient at a planetary scale. To close this efficiency gap, we propose instance-token aggregation, a scalable, training-free method that selects K seed tokens, assigns the remaining tokens to these seeds via cosine similarity, and aggregates each cluster into a single representative token. This approach yields substantial gains: at K=16, aggregation improves mAP by 17.9 points over raw token selection, and at K=64, it matches the accuracy of using all 196 tokens with significantly less storage. Finally, we demonstrate that a practical two-stage pipeline, with single-vector shortlisting followed by instance-token reranking, recovers 89-94% of the full late-interaction accuracy while searching only a small candidate set. The benchmark is publicly available at hf.co/datasets/jfang/CraterBench-R.

Nucleus instance segmentation in histology images is crucial for a broad spectrum of clinical applications. Current dominant algorithms rely on regression of nuclear proxy maps. Distinguishing nucleus instances from the estimated maps requires carefully curated post-processing, which is error-prone and parameter-sensitive. Recently, the Segment Anything Model (SAM) has earned huge attention in medical image segmentation, owing to its impressive generalization ability and promptable property. Nevertheless, its potential on nucleus instance segmentation remains largely underexplored. In this paper, we present a novel prompt-driven framework that consists of a nucleus prompter and SAM for automatic nucleus instance segmentation. Specifically, the prompter learns to generate a unique point prompt for each nucleus while the SAM is fine-tuned to output the corresponding mask for the prompted nucleus. Furthermore, we propose the inclusion of adjacent nuclei as negative prompts to enhance the model's capability to identify overlapping nuclei. Without complicated post-processing, our proposed method sets a new state-of-the-art performance on three challenging benchmarks. Code is available at github.com/windygoo/PromptNucSeg

Panoptic segmentation is the combination of semantic and instance segmentation: assign the points in a 3D point cloud to semantic categories and partition them into distinct object instances. It has many obvious applications for outdoor scene understanding, from city mapping to forest management. Existing methods struggle to segment nearby instances of the same semantic category, like adjacent pieces of street furniture or neighbouring trees, which limits their usability for inventory- or management-type applications that rely on object instances. This study explores the steps of the panoptic segmentation pipeline concerned with clustering points into object instances, with the goal to alleviate that bottleneck. We find that a carefully designed clustering strategy, which leverages multiple types of learned point embeddings, significantly improves instance segmentation. Experiments on the NPM3D urban mobile mapping dataset and the FOR-instance forest dataset demonstrate the effectiveness and versatility of the proposed strategy.

With the breakthrough of large models, Segment Anything Model (SAM) and its extensions have been attempted to apply in diverse tasks of computer vision. Underwater salient instance segmentation is a foundational and vital step for various underwater vision tasks, which often suffer from low segmentation accuracy due to the complex underwater circumstances and the adaptive ability of models. Moreover, the lack of large-scale datasets with pixel-level salient instance annotations has impeded the development of machine learning techniques in this field. To address these issues, we construct the first large-scale underwater salient instance segmentation dataset (USIS10K), which contains 10,632 underwater images with pixel-level annotations in 7 categories from various underwater scenes. Then, we propose an Underwater Salient Instance Segmentation architecture based on Segment Anything Model (USIS-SAM) specifically for the underwater domain. We devise an Underwater Adaptive Visual Transformer (UA-ViT) encoder to incorporate underwater domain visual prompts into the segmentation network. We further design an out-of-the-box underwater Salient Feature Prompter Generator (SFPG) to automatically generate salient prompters instead of explicitly providing foreground points or boxes as prompts in SAM. Comprehensive experimental results show that our USIS-SAM method can achieve superior performance on USIS10K datasets compared to the state-of-the-art methods. Datasets and codes are released on https://github.com/LiamLian0727/USIS10K.

This work presents a new dataset for the Martian digital elevation model prediction task, ready for machine learning applications called MCTED. The dataset has been generated using a comprehensive pipeline designed to process high-resolution Mars orthoimage and DEM pairs from Day et al., yielding a dataset consisting of 80,898 data samples. The source images are data gathered by the Mars Reconnaissance Orbiter using the CTX instrument, providing a very diverse and comprehensive coverage of the Martian surface. Given the complexity of the processing pipelines used in large-scale DEMs, there are often artefacts and missing data points in the original data, for which we developed tools to solve or mitigate their impact. We divide the processed samples into training and validation splits, ensuring samples in both splits cover no mutual areas to avoid data leakage. Every sample in the dataset is represented by the optical image patch, DEM patch, and two mask patches, indicating values that were originally missing or were altered by us. This allows future users of the dataset to handle altered elevation regions as they please. We provide statistical insights of the generated dataset, including the spatial distribution of samples, the distributions of elevation values, slopes and more. Finally, we train a small U-Net architecture on the MCTED dataset and compare its performance to a monocular depth estimation foundation model, DepthAnythingV2, on the task of elevation prediction. We find that even a very small architecture trained on this dataset specifically, beats a zero-shot performance of a depth estimation foundation model like DepthAnythingV2. We make the dataset and code used for its generation completely open source in public repositories.

A pre-trained visual-language model, contrastive language-image pre-training (CLIP), successfully accomplishes various downstream tasks with text prompts, such as finding images or localizing regions within the image. Despite CLIP's strong multi-modal data capabilities, it remains limited in specialized environments, such as medical applications. For this purpose, many CLIP variants-i.e., BioMedCLIP, and MedCLIP-SAMv2-have emerged, but false positives related to normal regions persist. Thus, we aim to present a simple yet important goal of reducing false positives in medical anomaly detection. We introduce a Contrastive LAnguage Prompting (CLAP) method that leverages both positive and negative text prompts. This straightforward approach identifies potential lesion regions by visual attention to the positive prompts in the given image. To reduce false positives, we attenuate attention on normal regions using negative prompts. Extensive experiments with the BMAD dataset, including six biomedical benchmarks, demonstrate that CLAP method enhances anomaly detection performance. Our future plans include developing an automated fine prompting method for more practical usage.

Recent advances in context optimization (CoOp) guided by large language model (LLM)-distilled medical semantic priors offer a scalable alternative to manual prompt engineering and full fine-tuning for adapting biomedical CLIP-based vision-language models (VLMs). However, prompt learning in this context is challenged by semantic misalignment between LLMs and CLIP variants due to divergent training corpora and model architectures; it further lacks scalability across continuously evolving families of foundation models. More critically, pairwise multimodal alignment via conventional Euclidean-space optimization lacks the capacity to model unified representations or apply localized geometric constraints, which tends to amplify modality gaps in complex biomedical imaging and destabilize few-shot adaptation. In this work, we propose vMFCoOp, a framework that inversely estimates von Mises-Fisher (vMF) distributions on a shared Hyperspherical Manifold, aligning semantic biases between arbitrary LLMs and CLIP backbones via Unified Semantic Anchors to achieve robust biomedical prompting and superior few-shot classification. Grounded in three complementary constraints, vMFCoOp demonstrates consistent improvements across 14 medical datasets, 12 medical imaging modalities, and 13 anatomical regions, outperforming state-of-the-art methods in accuracy, generalization, and clinical applicability. This work aims to continuously expand to encompass more downstream applications, and the corresponding resources are intended to be shared through https://github.com/VinyehShaw/UniEqui.

Learning visual representations is foundational for a broad spectrum of downstream tasks. Although recent vision-language contrastive models, such as CLIP and SigLIP, have achieved impressive zero-shot performance via large-scale vision-language alignment, their reliance on global representations constrains their effectiveness for dense prediction tasks, such as grounding, OCR, and segmentation. To address this gap, we introduce Region-Aware Cluster Discrimination (RICE), a novel method that enhances region-level visual and OCR capabilities. We first construct a billion-scale candidate region dataset and propose a Region Transformer layer to extract rich regional semantics. We further design a unified region cluster discrimination loss that jointly supports object and OCR learning within a single classification framework, enabling efficient and scalable distributed training on large-scale data. Extensive experiments show that RICE consistently outperforms previous methods on tasks, including segmentation, dense detection, and visual perception for Multimodal Large Language Models (MLLMs). The pre-trained models have been released at https://github.com/deepglint/MVT.

Efficient, reliable and reproducible target volume delineation is a key step in the effective planning of breast radiotherapy. However, post-operative breast target delineation is challenging as the contrast between the tumor bed volume (TBV) and normal breast tissue is relatively low in CT images. In this study, we propose to mimic the marker-guidance procedure in manual target delineation. We developed a saliency-based deep learning segmentation (SDL-Seg) algorithm for accurate TBV segmentation in post-operative breast irradiation. The SDL-Seg algorithm incorporates saliency information in the form of markers' location cues into a U-Net model. The design forces the model to encode the location-related features, which underscores regions with high saliency levels and suppresses low saliency regions. The saliency maps were generated by identifying markers on CT images. Markers' locations were then converted to probability maps using a distance-transformation coupled with a Gaussian filter. Subsequently, the CT images and the corresponding saliency maps formed a multi-channel input for the SDL-Seg network. Our in-house dataset was comprised of 145 prone CT images from 29 post-operative breast cancer patients, who received 5-fraction partial breast irradiation (PBI) regimen on GammaPod. The performance of the proposed method was compared against basic U-Net. Our model achieved mean (standard deviation) of 76.4 %, 6.76 mm, and 1.9 mm for DSC, HD95, and ASD respectively on the test set with computation time of below 11 seconds per one CT volume. SDL-Seg showed superior performance relative to basic U-Net for all the evaluation metrics while preserving low computation cost. The findings demonstrate that SDL-Seg is a promising approach for improving the efficiency and accuracy of the on-line treatment planning procedure of PBI, such as GammaPod based PBI.

Remote Sensing Image Captioning (RSIC) presents unique challenges and plays a critical role in applications. Traditional RSIC methods often struggle to produce rich and diverse descriptions. Recently, with advancements in VLMs, efforts have emerged to integrate these models into the remote sensing domain and to introduce descriptive datasets specifically designed to enhance VLM training. This paper proposes RS-MoE, a first Mixture of Expert based VLM specifically customized for remote sensing domain. Unlike traditional MoE models, the core of RS-MoE is the MoE Block, which incorporates a novel Instruction Router and multiple lightweight Large Language Models (LLMs) as expert models. The Instruction Router is designed to generate specific prompts tailored for each corresponding LLM, guiding them to focus on distinct aspects of the RSIC task. This design not only allows each expert LLM to concentrate on a specific subset of the task, thereby enhancing the specificity and accuracy of the generated captions, but also improves the scalability of the model by facilitating parallel processing of sub-tasks. Additionally, we present a two-stage training strategy for tuning our RS-MoE model to prevent performance degradation due to sparsity. We fine-tuned our model on the RSICap dataset using our proposed training strategy. Experimental results on the RSICap dataset, along with evaluations on other traditional datasets where no additional fine-tuning was applied, demonstrate that our model achieves state-of-the-art performance in generating precise and contextually relevant captions. Notably, our RS-MoE-1B variant achieves performance comparable to 13B VLMs, demonstrating the efficiency of our model design. Moreover, our model demonstrates promising generalization capabilities by consistently achieving state-of-the-art performance on the Remote Sensing Visual Question Answering (RSVQA) task.