38 7 64 8 ACUTE TOXICITY IN MICE
19 10 29 12 Mapleine
12 11 18 12 COMPOUND
61 13 65 15 B75
18 13 26 15 Crescent
12 14 17 15 SOURCE
52 14 60 15 LORILLARD NO
77 15 81 15 LOT NO
22 16 30 17 12 /4 /80
46 16 63 18 3 /12 /81 -3 /24 /81
71 16 80 18 3 /30 /81
12 17 20 18 DATE RECEIVED
42 17 46 18 TESTED:
64 17 69 18 REPORTED
23 19 50 21 H. S. Tong & A. A. Poole
77 19 85 21 BC19 -15
12 20 21 21 INVESTIGATOR (S)
68 20 77 21 NOTEBOOK PAGE:
24 21 67 25 
12 23 19 24 SIGNATURE (S)
21 28 35 30 Swiss- Webster
47 28 49 30 X
72 28 80 30 3/5/81
12 29 20 30 STRAIN OF MICE
43 29 46 30 MALE
51 29 55 30 FEMALE
62 29 70 30 DATE RECEIVED
31 31 36 32 16- 30
57 31 72 32 Camm Research
12 32 27 33 AVERAGE WEIGHT RANGE (GM)
51 32 55 33 SOURCE
12 35 32 36 ROUTE OF COMPOUND ADMINISTRATION
39 35 41 36 P.O.
46 35 47 36 X
64 35 70 36 INHALATION
47 35 49 36 I.P.
56 35 57 36 I.V.
75 37 90 38 pure solution
12 37 22 38 COMPOUND VEHICLE
31 38 42 39 % METHYL CELLULOSE
48 38 53 39 CORN OIL
69 38 70 39 X
70 38 74 39 OTHER
60 38 64 39 SALINE
15 43 20 44 GROUP NO.
28 43 35 44 % SOLUTION
47 43 57 45 DOSAGE (mg/kg) BODY WEIGHT
73 43 84 45 RESULTS (NO DEAD/NO TESTED
17 46 18 47 1
28 47 32 48 100
49 47 54 48 5000
73 47 77 48 0 /6
17 49 18 50 2
28 49 32 50 100
49 49 54 51 6000
73 49 77 51 0 /6
17 52 18 52 3
28 52 32 53 100
49 52 54 54 7200
73 52 77 54 0 /6
17 55 18 55 4
28 55 32 56 100
49 55 54 56 8640
73 55 77 57 0 /6
17 57 18 58 5
48 57 54 59 10368
28 57 32 59 100
73 58 77 59 0 /6
27 61 89 63 Weil, Carrol S., Biometrics, Vol. 8, No. 3., Sept. 1952,
12 62 26 63 REFERENCE FOR CALCULATION
11 64 19 65 p. 249.
27 66 47 69 LD0 = 10, 368 mg /kg
12 67 27 68 LD50 95% CONFIDENCE 
19 69 87 71 Higher doses were impractical. The recommended safe dose for
12 70 18 71 CONCLUSION:
11 72 84 77 trial inhalation in man is 80. 6, 40. 3, or 26. 8 mg per cigarette . when smoked 1, 2 or 3 cigarettes per hour, respectively.
91 74 94 83 87672097
11 79 38 81 Copies to the following:
40 79 58 83 H. J. Minnemeyer L. B. Gray
11 89 26 90 LORILLARD RESEARCH CENTER
84 90 90 91 FORM 
