5 2 18 4 RA/QA FORM 9
36 7 63 9 FINAL REPORT AMENDMENT
24 11 98 15 Acute Toxicity of Reference Cigarette Smoke lafter Inhalation in Mice.
13 12 24 13 Study Name
13 14 26 15 Study Number
28 14 40 15 I- 1725.001
34 16 49 17 25 March 1982
14 16 29 18 Initiation Date
61 18 76 20 27 April 1982
13 18 57 20 Date of Final Report (Review Completed Date)
14 20 64 22 Part of Final Report to be Amended (Exact location)
15 23 82 25 The attached is an addition to the I- 1725.001 Final Report
39 30 98 32 Survival after repeated doses over a 14 day period
13 31 38 32 Reason for the Amendment
15 32 92 36 may not be accurately predicted from survival after a single day's exposure.
64 40 96 41 The report of the results of
14 40 62 42 Amendment (Attach additional sheets as necessary)
17 42 93 46 A 14 Day Repeated Dose Assay for Reference Cigarette Smoke in Mice (I- 1725.001- M1 is attached.
63 57 84 61 
17 58 30 61 16/3/82
65 61 79 62 STUDY DIRECTOR
19 61 25 63 DATE
49 65 81 67 ACCEPT/REJECT (as per 58.185 (c))
14 65 24 66 APPROVALS
60 66 89 70 
47 68 57 70 Accept
14 68 31 71 03 June 1982
64 70 88 71 QUALITY ASSURANCE ASSOC.
65 71 79 75 
17 72 32 77 3 June 1982
47 72 57 75 Accept
64 74 84 76 DIRECTOR OF RESEARCH
61 76 89 79 
15 77 31 80 3 June 1982
46 77 55 80 Accept
64 79 82 80 DIRECTOR OF RA/QA
93 80 96 89 89368010
63 84 78 87 
47 85 59 87 
14 85 44 87 Received by REGULATORY AFFATRS
64 87 83 88 REGULATORY AFFAIRS
