92 1 94 2 24
47 1 58 3 ADDENDUM II
28 4 71 6 COMPOUND PHYSICAL PARAMETERS
65 8 68 8 DATE
8 8 19 9 LRC COMPOUND CODE
70 9 79 10 11/1381
22 9 26 10 A32
8 11 19 11 MOLECULAR WEIGHT
66 11 72 11 ESTIMATED
33 11 39 11 SOLUBILITY
50 11 56 11 MEASURED
87 12 91 13 g100ml
20 12 27 13 200. 29
67 12 72 13 AMOUNT
45 12 49 13 OTHER
35 12 39 13 WATER
8 13 11 14 CLASS
66 14 70 15 OTHER
19 14 22 15 ACID
37 14 40 15 BASE
52 14 54 15 SALT
8 17 14 18 REACTIVITY
50 17 65 18 DESCRIPTION OF REACTIVITY
35 19 45 20 WITHOUT HEATING
68 19 79 20 WITH HEATING (80C)
10 21 21 22 1) WATER or BRINE:
65 21 71 22 UNCHANGED
79 21 87 22 DECOMPOSITION
32 21 38 22 UNCHANGED
45 21 54 22 DECOMPOSITION
65 24 71 25 UNCHANGED
11 24 16 25 2) 5% HCL
31 24 38 25 UNCHANGED
45 24 54 25 DECOMPOSITION
79 24 87 25 DECOMPOSITION
11 27 17 28 3) 5% NaOH:
78 27 87 28 DECOMPOSITION
31 27 38 28 UNCHANGED
45 27 54 28 DECOMPOSITION
64 27 71 28 UNCHANGED
11 30 18 31 4) ALCOHOLS:
32 30 38 31 UNCHANCED
45 30 53 31 DECOMPOSITION
65 30 71 31 UNCHANGED
79 30 87 31 DECOMPOSITION
79 32 87 33 DECOMPOSITION
11 33 17 33 5) OXYGEN:
32 33 38 33 UNCHANGED
45 33 54 33 DECOMPOSITION
65 33 71 33 UNCHANGED
65 35 71 36 UNCHANGED
11 35 16 36 6) LIGHT:
32 35 38 36 UNCHANGED
45 35 54 36 DECOMPOSITION
78 35 87 36 DECOMPOSITION
8 37 37 38 SAFETY COMMENTS (SUGGESTED HANDLING PROCEDURE)
84 38 86 47 00837285
8 47 18 48 CHEMICAL PURITY
50 47 63 48 ANALYTICAL METHOD(S)
63 50 89 54 X SPECIAL STORAGE Refrigerate in amber bottle at no more than * C
8 51 24 52 STORAGE RECOMMENDATIONS
39 51 49 52 NORMAL STORAGE
9 53 22 54 COMPOUND SENSITIVE TO
16 55 19 56 HEAT
41 55 45 56 OTHER
10 55 12 56 AIR
24 55 26 56 LIGHT
31 55 36 56 MOISTURE
8 58 15 59 COMMENTS
12 61 91 67 pH- The pH of a 50% concentration of A32 in a 52.6% dioxane/water solution was calculated to be 2.92 at 22°C according to the extra- polation procedures by Dr. P. D. Schickedantz, Lorillard Research Center Accession No. 1662, Reference OR 83- 125.
12 68 65 69 Solubility (See SOP for Biological Solutions)
12 70 92 74 Oral- 5g A32 forms a suspension with stirring in 10 ml 1% Tween 80 at room temperature. Reference OR 72- 151.
12 75 93 79 Acute Cardiovascular- Mix 2 mg A32 with 0.2 ml 80% propylene glycol and grind lightly. Add 0.8 ml saline solution. A32 is a suspension in this mixture at room temperature. Reference OR 72- 152.
72 84 86 89 
12 85 48 87 
65 85 69 86 DATE
9 85 15 86 SIGNATURE
86 88 93 89 FORM 
9 88 25 89 LORILLARD RESEARCH CENTER
