37 5 65 7 ACUTE TOXICITY IN MICE
18 9 65 11 3-Hydroxy-3-methylbutanoic acid (Tur 13)
10 10 17 11 COMPOUND
64 12 72 14 OR39- 23
86 12 89 15 A4
18 12 52 15 Lorillard - Organic Chemistry
10 14 15 15 SOURCE
52 14 60 15 LORILLARD NO
79 14 83 15 
73 14 91 18 5/3/79 10/6/80 , Update
23 16 28 18 Unk.
48 16 58 18 12/28/78
42 17 46 18 TESTED
65 17 70 18 REPORTED
10 17 19 18 DATE RECEIVED
25 19 54 21 H. S. Tong & M. S. Forte'
81 19 91 20 B1014- 23
10 20 19 21 INVESTIGATOR(S)
69 20 79 21 NOTEBOOK PAGE
23 21 93 26 
10 23 18 24 SIGNATURE(S)
47 28 49 30 X
20 28 36 30 Swiss- Webster
76 28 81 30 Unk.
42 29 46 31 MALE
51 29 56 30 FEMALE
10 29 19 31 STRAIN OF MICE
63 29 72 31 DATE RECEIVED
60 32 76 33 Camm Research
10 32 26 33 AVERAGE WEIGHT RANGE (GM)
51 32 56 33 SOURCE
37 36 38 37 ☑
38 36 40 37 P.O.
10 36 31 37 ROUTE OF COMPOUND ADMINISTRATION
46 36 49 37 ☐ I.P.
55 36 58 37 ☐ I.V.
64 36 72 37 ☐ INHALATION
25 38 28 40 ☑
10 39 21 40 COMPOUND VEHICLE
28 39 42 40 .5 % METHYL CELULOSE
47 39 54 40 ☐ CORN OIL
59 39 65 40 ☐ SALINE
70 39 75 40 ☐ OTHER
13 44 19 45 GROUP NO.
28 44 34 45 % SOLUTION
47 44 58 47 DOSAGE (mg/ kg BODY WEIGHT)
75 45 87 46 RESULTS (NO TESTED)
15 48 16 49 1
27 48 29 50 5
49 48 54 50 1800
73 48 77 50 1/ 6
15 51 17 52 2
74 51 78 53 0/ 6
26 51 29 53 10
48 51 54 53 2160
15 54 17 55 3
74 54 77 56 0/ 6
26 54 29 56 10
49 54 53 56 2592
15 57 17 58 4
74 57 77 59 3/ 6
49 57 54 59 3732
27 57 29 59 10
15 60 17 61 5
49 60 54 62 4479
74 60 77 62 6/ 6
26 60 29 62 10
29 63 90 66 Litchfield, J. T. and Wilcoxin F. , J. of Pharmacol
10 65 26 66 REFERENCE FOR CALCULATION
11 67 46 69 and Exper. Ther. , 90: 99 , 1948.
30 70 54 72 3.5 (3.1 to 3.9 g /kg
10 71 26 72 LD50 (95% CONFIDENCE LIMITS)
17 72 90 74 This compound appears to act as a CNS depressant with symptons
10 74 17 75 CONCLUSION
11 75 88 83 of respiratory depression, constriction of blood vessels, and in- activity. Survivors recovered in 48 hours. The recommended safe dose for a single trial by inhalation in man is 0.3 mg.
87 82 90 92 00040534
44 86 68 89 Dr. H. J. Minnemeyer Ms. L. B. Gray
11 86 39 88 Copies to the Following:
10 94 25 95 LORILLARO RESEARCH CENTER
87 94 94 95 FORM 7 5/80
