question: When a part of your skin with a mole gets wounded, will the regenerated skin grow the same mole?
comment: It depends on the wound, but generally it will regrow as long as some of those tissues survive. *Think of it similarly to a weed, as long as the root cells live... the whole thing will regrow everytime.* A professional will usually freeze it, and then cut under the mole with a sharp scalpel. It might get some basic guaze and bandages, or a few quick stitches depending on the size of the cut. Afterwards, new skin will fill the hole. *Edit: The removed mole is usually tested for cancer.*
passages: Mole removal risks mainly depend on the type of mole removal method the patient undergoes. First, mole removal may be followed by some discomfort that can be relieved with pain medication. Second, there is a risk that a scab will form or that redness will occur. However, such scabs and redness usually heal within one or two weeks. Third, as in other surgeries, there is also risk of infection or an anesthetic allergy or even nerve damage. Lastly, the mole removal may imply an uncomfortable scar depending on the mole size.
  
  Section::::History.
   In 2016, a report was published that recorded the first ever discovered malignancies in two naked mole-rats, in two individuals. However, both naked mole-rats were captive-born at zoos, and hence lived in an environment with 21% atmospheric oxygen compared to their natural 2–9%, which may have promoted tumorigenesis.
  
  The Golan Heights blind mole-rat ("Spalax golani") and the Judean Mountains blind mole-rat ("Spalax judaei") are also resistant to cancer, but by a different mechanism.
  
  Section::::Physiology.:Longevity.
   His colleague, Jean-Baptiste Lamarck, named a number of vestigial structures in his 1809 book "Philosophie Zoologique". Lamarck noted "Olivier's "Spalax", which lives underground like the mole, and is apparently exposed to daylight even less than the mole, has altogether lost the use of sight: so that it shows nothing more than vestiges of this organ."
   In 2012, during the band's 'Almost World Tour' guitarist Tom Searle noticed what he perceived to be a mole on his leg which irritated him. He proceeded to have it examined, where it was cleared as non-cancerous and removed at the end of the tour once returning home. However, a few weeks after its removal, Searle was contacted by doctors as having Melanoma skin cancer, which would eventually lead to his death in 2016..
   In some cases (3-7%) mutated versions of BRAF and NRAS undergo copy number amplification. 
  
  Section::::Diagnosis.
  
  Visual inspection is the most common diagnostic technique. Moles that are irregular in color or shape are typically treated as candidates. To detect melanomas (and increase survival rates), it is recommended to learn to recognize them (see "ABCDE" mnemonic), to regularly examine moles for changes (shape, size, color, itching or bleeding) and to consult a qualified physician when a candidate appears.
   BULLET::::- Nowak, R. M. 1999. Walker's Mammals of the World, Vol. 2. Johns Hopkins University Press, London.
  
  BULLET::::- Seney ML, Kelly DA, Goldman BD, Šumbera R, Forger NG (2009) Social Structure Predicts Genital Morphology in African Mole-Rats. PLoS ONE 4(10): e7477. doi: 10.1371/journal.pone.0007477. Figure
  
  BULLET::::- Mitgutsch, C., Richardson, M. K., Jiménez, R., Martin, J. E., Kondrashov, P., de, B. M. A., & Sánchez-Villagra, M. R. (January 1, 2012). Circumventing the polydactyly 'constraint': the mole's 'thumb'. Biology Letters, 8, 1, 74-7.
   In the "Live Fast" story arc of "Runaways", the Runaways are fighting a huge tall sky-scraper sized monster. When Victor suggests Nico shrink it, Nico mentions she already used that spell on Mole Man.
   In properly trained hands, some medical lasers are used to remove flat moles level with the surface of the skin, as well as some raised moles. While laser treatment is commonly offered and may require several appointments, other dermatologists think lasers are not the best method for removing moles because the laser only cauterizes or, in certain cases, removes very superficial levels of skin. Moles tend to go deeper into the skin than non-invasive lasers can penetrate. After a laser treatment a scab is formed, which falls off about seven days later, in contrast to surgery, where the wound has to be sutured. A second concern about the laser treatment is that if the lesion is a melanoma, and was misdiagnosed as a benign mole, the procedure might delay diagnosis. If the mole is incompletely removed by the laser, and the pigmented lesion regrows, it might form a recurrent nevus.
   A basic reference chart used for consumers to spot suspicious moles is found in the mnemonic A-B-C-D, used by institutions such as the American Academy of Dermatology and the National Cancer Institute. The letters stand for asymmetry, border, color, and diameter. Sometimes, the letter E (for elevation or evolving) is added. According to the American Academy of Dermatology, if a mole starts changing in size, color, shape or, especially, if the border of a mole develops ragged edges or becomes larger than a pencil eraser, it would be an appropriate time to consult with a physician. Other warning signs include a mole, even if smaller than a pencil eraser, that is different from the others and begins to crust over, bleed, itch, or become inflamed. The changes may indicate developing melanomas. The matter can become clinically complicated because mole removal depends on which types of cancer, if any, come into suspicion.
   BULLET::::- Evolution: The evolution (i.e. change) of a mole or lesion may be a hint that the lesion is becoming malignant.
  
  The E is sometimes omitted, as in the ABCD guideline. A weakness in this system is the D. Many melanomas present themselves as lesions smaller than 6 mm in diameter. An astute physician will examine all abnormal moles, including ones less than 6 mm in diameter. Unfortunately for the average person, many seborrheic keratoses, some lentigo senilis, and even warts may have ABCD characteristics, and cannot be distinguished from a melanoma without a trained eye or dermatoscopy.
   The types of ro-langs above are listed in order of difficulty to defeat. The skin-zombie is considered the easiest to defeat because the skin is easy to break, whereas the mole-zombie is considered to be the most difficult to defeat because of the small area of vulnerability, and the potential for the location of the mole to be unknown to the intended victim.
   -Inducing cancer with chemical carcinogens that lead to 100% of the expected tumors in mice and rats after 2–6 months, respectively, indicate an extraordinary cancer resistance of Spalax: Only 2 out of 12 animals, and old ones (10 years old; Spalax can live ~20 years; 5 times longer than its evolutionary relative, the rat) developed the expected tumor with one of the carcinogens and only after 18 and 30 months.
   Studies on the growth of fibroblasts "in vitro" of "Spalax judaei" and "Spalax golani" showed that the process of necrosis replaces the role of the systematic apoptosis normally used in most organisms. Low-oxygen conditions, such as those common in blind mole rats’ burrows, usually cause cells to undergo apoptosis. One study showed that in adaptation to a higher tendency of cell death, blind mole rats evolved a mutation in the tumor suppressor protein p53, also used in humans, to prevent cells from undergoing apoptosis. Human cancer patients have similar mutations, and blind mole rats were thought to be more susceptible to cancer because their cells cannot undergo apoptosis. However, after a specific amount of time (within 3 days according to one study), the cells in blind mole rats release interferon-beta (which the immune system normally uses to counter viruses) in response to overproliferation of cells caused by the suppression of apoptosis. In this case, the interferon-beta triggers cells to undergo necrosis, and this mechanism also kills cancer cells in blind mole rats. Because of tumor suppression mechanisms such as this, blind mole rats and other spalacids are resistant to cancer.
   Section::::Classification.
  
  Up to 12 subspecies of "S. latimanus" have been recognized, but a taxonomic revision published in 2004 recommended the southernmost subspecies, "S. l. anthonyi" (Anthony's Mexican mole) be elevated to full species, and recognized only 5 subspecies of "S. latimanus". Anthony's Mexican mole is the smallest species (or subspecies) in the genus "Scapanus" and differs from "S. latimanus" in dental and cranial characteristics.
   Electrocautery is available as an alternative to laser cautery. Electrocautery is a procedure that uses a light electrical current to burn moles, skin tags, and warts off the skin. Electric currents are set to a level such that they only reach the outermost layers of the skin, thus reducing the problem of scarring. Approximately 1-3 treatments may be needed to completely remove a mole. Typically, a local anesthetic is applied to the treated skin area before beginning the mole removal procedure.
   According to the National Cancer Institute, researchers have shown that atypical moles are more likely than ordinary moles to develop into a type of skin cancer called melanoma. It is worth noting that the vast majority of atypical moles will never become malignant. However, numerous studies indicate that about half of melanomas arise from atypical moles. Evidence supporting this connection arises from clinical photodocumentation of evolving lesions, patient self-reports of changing lesions, pathology studies showing dysplastic nevi in histologic contiguity with melanoma, and epidemiology studies indicating that about half of individuals affected by melanoma also have atypical moles. Epidemiology studies have also shown that individuals with multiple dysplastic nevi are at much higher risk for developing melanomas. Because of this, moles should be checked regularly by a doctor or nurse specialist, especially if they look complex; grow larger; change in color or shape; or if "any" changes occur, such as itching, flaking or oozing.
   In rare cases a hydatidiform mole co-exists in the uterus with a normal, viable fetus. These cases are due to twinning. The uterus contains the products of two conceptions: one with an abnormal placenta and no viable fetus (the mole), and one with a normal placenta and a viable fetus. Under careful surveillance it is often possible for the woman to give birth to the normal child and to be cured of the mole.
  
  Section::::Pathophysiology.:Parental origin.
   Naked mole-rats have a high resistance to tumours, although it is likely that they are not entirely immune to related disorders. A potential mechanism that averts cancer is an "over-crowding" gene, p16, which prevents cell division once individual cells come into contact (known as "contact inhibition"). The cells of most mammals, including naked mole-rats, undergo contact inhibition via the gene p27 which prevents cellular reproduction at a much higher cell density than p16 does. The combination of p16 and p27 in naked mole-rat cells is a double barrier to uncontrolled cell proliferation, one of the hallmarks of cancer.
   Section::::Conservation status.
  
  "Mogera robusta" has a wide range and is said to be abundant in some areas and common in others. Although it used to be hunted for its pelt, this is no longer the case and it now faces no particular threats. The International Union for Conservation of Nature has rated its conservation status as being of "least concern" because, although its population may be in slow decline, this is not at a fast enough rate to warrant listing it in a more threatened category.
  
  Section::::References.
   A married businessman loves the mole on his wife's back. In their twenty years of marriage, he has made it a habit to kiss the mole every day and even ejaculate on it after sexual intercourse with his wife; the only time he has almost been unfaithful was when a prostitute had a similar mole. One day, he comes home and cannot find it on her body; she says that she has never had a mole. After several days of looking for and asking about it, he becomes depressed and refuses to touch his wife; he eventually locates the prostitute he had refused before and has sex with her. At her massage, his wife talks to her masseuse and reveals that she had had the mole removed by laser as she wanted her husband's attention; the masseuse, who had mentioned the technique, holds her tight and says that she is still there.
   Where mole-hills are not desired, the moles may be killed or, preferably, deterrent plants like caper spurge or the related castor bean plant can be planted. The fresh molehills can also be removed carefully as soon as they appear. This leaves the animals and their galleries undamaged and thus reduces the need for the moles to make further molehills when they clear earth out of the tunnels.
   If a melanocytic nevus is suspected of being a melanoma, it needs to be sampled or removed and sent for microscopic evaluation by a pathologist by a method called skin biopsy. One can do a complete excisional skin biopsy or a punch skin biopsy, depending on the size and location of the original nevus. Other reasons for removal may be cosmetic, or because a raised mole interferes with daily life (e.g. shaving). Removal can be by excisional biopsy or by shaving. A shaved site leaves a red mark on the site which returns to the patient’s usual skin color in about two weeks. However, there might still be a risk of spread of the melanoma, so the methods of Melanoma diagnosis, including excisional biopsy, are still recommended even in these instances. Additionally, moles can be removed by laser, surgery or electrocautery.
   The DNA repair transcriptomes of the liver of humans, naked mole rats and mice were compared. The maximum lifespans of humans, naked mole rats, and mice are respectively c. 120, 30 and 3 years. The longer-lived species, humans and naked mole rats, expressed DNA repair genes, including core genes in several DNA repair pathways, at a higher level than did mice. In addition, several DNA repair pathways in humans and naked mole rats were up-regulated compared with mice. These findings suggest that increased DNA repair facilitates greater longevity, and also are consistent with the DNA damage theory of aging.
  
  Section::::Physiology.:Size.
   Section::::Use in research.
  
  According to Israeli researchers at Haifa University, the Middle East blind mole-rat is the ultimate lab animal for researching cancer due to its extraordinary resistance to the disease. In their publication [Manov et al., BMC Biology, 2013][4] interesting data on Spalax resistance to cancer have been documented:
  
  -No spontaneous tumors have ever been noticed in blind mole rat, based on observing thousands of individuals along half a century.
   During the "Secret Empire" storyline, it is revealed that Mole Man has struck a deal with Captain America to use the tunnels of his subterranean kingdom for his smuggling operation in exchange for specific items from the surface world, such as DVDs. When Captain America arrives with the Underground Resistance, Mole Man's kingdom is attacked by Dreadnoughts sent by Hydra. Though the heroes manage to defeat the Dreadnoughts, Mole Man puts an end to his truce with Captain America and lets the heroes leave.
  
  Section::::Powers and abilities.
  