question: How do our organs stay in place and not get jumbled up over the years?
comment: They are wrapped in membranes and held in general place by connective tissues. Additionally, although they have some "squish," they also have some structure and shape, and generally fit together a certain way. Imagine filling some water balloons with jello before it's set, and packing them tightly into a lunchbox. Once the jello has set, shake the lunchbox a bit - the balloons will stay in roughly the same locations.
passages: Skeletal tissues are generally placed directly on the grid but softer tissues like glands or skin are first placed on rafts, which are then kept on the grids.
  
  The grids themselves are placed in a culture chamber filled with fluid medium up to the grid; the chamber is supplied with a mixture of O and CO to meet the high O requirements of adult mammalian organs. A modification of the original grid method is widely used to study the growth and differentiation of adult and embryonic tissues.
  
  Section::::Uses.
   Section::::Combination action.:Mechanical systems.
   Section::::Combination action.:Mechanical systems.:Saint-Sulpice.
   Takebe et al. demonstrate a generalized method for organ bud formation from diverse tissues by combining pluripotent stem cell-derived tissue-specific progenitors or relevant tissue samples with endothelial cells and mesenchymal stem cells. They suggested that the less mature tissues, or organ buds, generated through the self-organized condensation principle might be the most efficient approach toward the reconstitution of mature organ functions after transplantation, rather than condensates generated from cells of a more advanced stage.
  
  Section::::Properties.
   In most published reports about tissue heart valve replacement, there are differences in the presentation of data and of the results in all aspects of a particular topic between the various publications. In almost all chapters of valve function, with the exception of haemodynamic and hydraulic measurements - which are scientifically obtained and mathematically expressed - there are differences from author to author. Why in the hands of one surgeon, the same type of tissue valve fails in one patient at 24 months, and in another one it lasts 243 months? Microscopic studies performed on porcine and pericardial valves, explanted because of failure between 12 months and 6 years, all showed gross histological changes in the structure of tissue. In view of these changes in those valves, how did some of the porcine and pericardial valves continue to function well beyond 10 years? Why did the rate of occurrence of bacterial endocarditis differ from one hospital to another, and the embolic rate vary from surgeon to surgeon?
   In a combination of raft and clot techniques, the explants are first placed on a suitable raft, which is then kept on a plasma clot. This modification makes media changes easy, and prevents the sinking of explants into liquefied plasma.
  
  Section::::Methodology.:In vitro culture.:Agar gel method.:Grid Method.
  
  Initially devised by Trowell in 1954, the grid method utilizes 25 mm x 25 mm pieces of a suitable wire mesh or perforated stainless steel sheet whose edges are bent to form 4 legs of about 4 mm height.
   The cells are sensitive to the environment, such as gel stiffness and contact with other cells. Individual cells do not thrive; a minimum of four proximate cells was required for subsequent organoid development. Modifications to the medium composition produced either hollow spheres mainly composed of pancreatic progenitors, or complex organoids that spontaneously undergo pancreatic morphogenesis and differentiation. Maintenance and expansion of pancreatic progenitors require active Notch and FGF signaling, recapitulating in vivo niche signaling interactions.
  
  The organoids were seen as potentially offering mini-organs for drug testing and for spare insulin-producing cells.
  
  Section::::Tissue culture.
   Section::::Organ building career.
   The Hook firm built over 2,000 pipe organs, many of which are still extant today. Some remain in unaltered, original condition, such as the three-manual instrument at First Unitarian Church in Jamaica Plain, Massachusetts; others have been tonally and/or physically altered due to changing trends in the organ world during the 20th century.
   Section::::Prognosis.
  
  If there are no other defects, the prognosis after surgical repair of this condition is relatively good. However, 10% of those with more severe or additional abnormalities die from it. The organs themselves are fully functional; the difficulty lies in fitting them inside the abdomen. The condition is, in fact, a hernia requiring only replacement and strengthening of the passageway through which it occurred. After surgery, increased pressure in the stretched abdomen can compromise the function of the organs inside.
  
  Section::::Incidence.
   The femoral stem is usually made of cobalt chrome or stainless steel, while the cup is made of ultra high molecular weight polyethylene. Polymethyl methacrylate is the cement used with cemented implants, whereas 250-micrometres (diameter) titanium beads usually cover the stem surface of the press-fit implants.
  
  The THR is expected to last 10–15 years, which usually surpasses the remaining lifetime of the dog. In less than 5% of cases, the THR will malfunction through loosening of the acetabular cup or femoral fracture. These failures require correction with revision surgery.
  
  Section::::Pacemaker implants.
   To be more historically accurate, organs built along historical models will often use older schemes for organizing the keydesk controls.
  
  Section::::Keyboards.
   Section::::Management.:Before 24 weeks.
  
  Before 24 weeks, a fetus is not viable meaning it cannot live outside the mother. In this case, either watchful waiting at home or an induction of labor done.
   j) Multiple muscular VSDs are a challenge to close, achieving a complete closure can be aided by the use of fluorescein dye.
  
  Section::::Epidemiology.
   Section::::Construction.
   Section::::Major Niehoff projects - "BOLD entried organs still extant in 2006".
  
  BULLET::::- 1534 Breda - Groote / The positive case on the current organ survives from 1534; information on the 1534 case is taken from a book about the organs in this church which was published in 1989. Jan van Biezen states this organ was built by Jan Graurock; whether or not Niehoff helped is debatable.
   Developments in echocardiography, both the technology of the machines and the skill of the operators, have made it no longer necessary to see the endocardium at autopsy. EFE can now be found non-invasively by the recording of increased endocardial echos. Fetal echocardiography has shown that EFE can begin to accumulate as early as 14 weeks of gestation, and increase with incredible rapidity and even that it can be reversed if the stress can be removed early in fetal life.
   In 2013, Madeline Lancaster at the Austrian Academy of Sciences established a protocol for culturing cerebral organoids derived from stem cells that mimic the developing human brain's cellular organization.
  
  In 2014, Artem Shkumatov et al. at the University of Illinois at Urbana-Champaign demonstrated that cardiovascular organoids can be formed from ES cells through modulation of the substrate stiffness, to which they adhere. Physiological stiffness promoted three-dimensionality of EBs and cardiomyogenic differentiation.
   1st - In a box 7 to 9 inches long, 3½ inches wide and 2 inches high, feathers of metal plates are fixed, which were known for more than 200 years as Regale, Zungen, Schnarrwerk, in organs.
  
  2nd - With bellows fixed to the above box and its 5 claves fixed below, even an amateur of music can play the loveliest and most moving chords of 3, 4 and 5 voices with very little practice.
   Tissue valves can last 10–20 years. However, they tend to deteriorate more quickly in younger patients. New ways of preserving the tissue for longer are being investigated. One such preservation treatment is now being used in a commercially available tissue heart valve. In sheep and rabbit studies, the tissue (called RESILIA™ tissue) had less calcification than control tissue. However, long-term durability data in patients are not yet available.
   Early combinations of pipe organs and electronic technology (including the electronic tone generators, at later) were developed in the 1930s. Custom electronic organ consoles occasionally replace aging pipe consoles, updating the electrical control system for the pipes as well as adding electronic voices to the organ. Even large pipe organs are often supplemented with electronic voices for the deepest bass tones that would otherwise require 16- to 32-foot pipes.
   This has its drawbacks. No matter how a swell box is designed, the sound of the pipes is compromised by enclosing them. Since much organ repertoire was written before gradual crescendo and decrescendo effects became common, this seems to represent an unnecessary degradation of the music. On the other hand, building an organ with no swell box – and thus unable to play later music – also seems to be a compromise.
   The donor heart and lungs are positioned and sewn into place. As the donor organs warm up to body temperature, the lungs begin to inflate. The heart may fibrillate at first - this occurs because the cardiac muscle fibres are not contracting synchronously. Internal paddles can be used to apply a small electric shock to the heart to restore proper rhythm.
  
  Once the donor organs are functioning normally, the heart-lung machine is withdrawn, and the chest is closed.
  
  Section::::Main organs.:Kidney.
   Dysplastic kidneys are prevalent in over 95% of all identified cases. When this occurs, microscopic cysts develop within the kidney and slowly destroy it, causing it to enlarge to 10 to 20 times its original size. The level of amniotic fluid within the womb may be significantly altered or remain normal, and a normal level of fluid should not be criteria for exclusion of diagnosis.
   The action is also engineered for compactness. In early designs, the action was very simple and comprised a sprung arrangement where air was compressed in the lower chest of the organ, and depressing a key would open a pallet that would release the air up to the pipe ranks. Later designs, as technology progressed, started to encompass more of what could be found in church and other organs and more complex mechanisms, including rollerboards, pedalboards, reed organs (rather than pipes), and eventually electric rather than mechanical actions.
  
raw_presuppositions: Internal organs are free to move around in the body.
raw_corrections: Internal organs are held in place by membranes and connective tissue.