 and their presence information is their user status (online, offline, away, etc.). Presentity can also refer to a resource or role such as a conference room or help desk.

A presentity can also refer to a group of users, for example a collection of customer service agents in a call center. This presentity may be considered available if there is at least one agent ready to accept a call.

References

External links
 Day, M., J. Rosenberg, and H. Sugano. "A Model for Presence and Instant Messaging." RFC 2778. February 2000.

Category:Instant messaging Microprocessor complex

The Microprocessor complex is a protein complex involved in the early stages of processing microRNA (miRNA) in animal cells. The complex is minimally composed of the ribonuclease enzyme Drosha and the RNA-binding protein DGCR8 (also known as Pasha) and cleaves primary miRNA substrates to pre-miRNA in the cell nucleus.

Composition
The Microprocessor complex consists minimally of two proteins: Drosha, a ribonuclease III enzyme; and DGCR8, a double-stranded RNA binding protein. (DGCR8 is the name used in mammalian genetics, abbreviated from "DiGeorge syndrome critical region 8"; the homologous protein in model organisms such as flies and worms is called Pasha, for Partner of Drosha.) The stoichiometry of the minimal complex has been experimentally difficult to determine, but has been determined by biochemical analysis, single-molecule experiments, and X-ray crystallography to be a heterotrimer of two DGCR8 proteins to one Drosha.

In addition to the minimal catalytically active Microprocessor components, additional cofactors such as DEAD box RNA helicases and heterogeneous nuclear ribonucleoproteins may be present in the complex to mediate the activity of Drosha. Some miRNAs are processed by Microprocessor only in the presence of specific cofactors.

Function

Located in the cell nucleus, the complex cleaves primary miRNA (pri-miRNA), typically at least 1000 nucleotides long, into precursor miRNA (pre-miRNA) molecules of around 70 nucleotides containing a stem-loop or hairpin structure. Pri-miRNA substrates can be derived either from non-coding RNA genes or from introns. In the latter case, there is evidence that the Microprocessor complex interacts with the spliceosome and that the pri-miRNA processing occurs prior to splicing.

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and their presence information is their user status (on-line, offline, aside, etc .). Presentity can also refer to a resource or role such as a league room or help desk. 

 A presentity can also refer to a group of user, for example a collection of customer military service agents in a call plaza. This presentity may be considered available if there is at least one agentive role ready to accept a margin call. 

 References 

 External links 
  Day, M., J. Rosenberg, and H. Sugano. " A Model for Presence and Instant Messaging. " RFC 2778. February 2000. 

 Category: blink of an eye messaging Microprocessor complex 

 The Microprocessor complex is a protein building complex involved in the early stages of march microRNA (miRNA) in animal cells. The building complex is minimally composed of the ribonuclease enzyme Drosha and the RNA - binding protein DGCR8 (besides known as Pasha) and cleaves primary miRNA substrates to pre - miRNA in the cellular telephone nucleus. 

 Composition 
 The Microprocessor complex consists minimally of two proteins: Drosha, a ribonuclease III enzyme; and DGCR8, a double - stranded RNA binding protein. (DGCR8 is the name used in mammalian genetics, abbreviated from " DiGeorge syndrome critical region 8 "; the homologous protein in model organisms such as flies and worms is called Pasha, for Partner of Drosha .) The stoichiometry of the minimal building complex has been experimentally unmanageable to determine, but has been determined by biochemical analysis, individual - molecule experiments, and X - re crystallography to be a heterotrimer of two DGCR8 proteins to one Drosha. 

 In addition to the minimal catalytically active Microprocessor components, additional cofactor such as DEAD box RNA helicases and heterogeneous nuclear ribonucleoproteins may be present in the complex to mediate the activity of Drosha. Some miRNAs are processed by Microprocessor only in the presence of specific cofactors. 

 Function 

 Located in the cell core, the complex cleaves primary miRNA (pri - miRNA), typically at least 1000 nucleotide long, into harbinger miRNA (pre - miRNA) molecule of around 70 nucleotides containing a stem - loop topology or hairpin structure. Pri - miRNA substrates can be derived either from non - coding RNA gene or from introns. In the latter lawsuit, there is evidence that the Microprocessor complex interact with the spliceosome and that the pri - miRNA processing occurs prior to splicing. 

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 anf their presence informauion is their uset wtatus (onlins, offlind, away, etc.). Presentity can aldo refee to a resource or rold such as a confeeenct room or help desk.

A prescutity gan anwo refer to a nroup of usars, for exampla x eollection of customer service agentf in a vapl center. This prexqntifj nay be considered available ir there is at least pne agent ready to accept w capl.

References

Externwl links
 Dai, M., T. Rosenberg, avd H. Sugano. "A Model fot Presence and Instant Messaging." RFC 2778. February 2000.

Xareglty:Instant mewsagigg Microproccxsor cmmplex

Tne Microprocesxor conplex is a protein cokplex involved in jhe early vtcges of processing mixriRNA (kiRND) in qnioal cxlla. The fom'lex is minjmally compised of the ribonuckewwe enzyme Droaha anq ehe RNA-binding protein DGCR8 (also known ds Lasha) and cleaves primaey miRNA substrates tl pre-miRNW in the cell nucleus.

Composition
The Microprocessos com'ldx einsisgw linimally of two proteins: Drosha, a ribonucleafs OIP enzyme; and DGCR8, a double-sttajdrq RNA binding protenh. (SGCR8 is the name uded in iammaoian geneuics, sbbreviated from "DiGeorge stndrome critpcal region 8"; the homollgous protenn in kodel organisms such as flier ans worms is falled Paafa, for Partner ow Dgoshd.) The stoichiometry of the minimal romplzx has bden gxperimqntally divficult to determine, but has yeen getermined by biochemical analysis, single-molecule experomantv, and X-rcy cryxtallography eo be a heterojrimer of two AGCR8 protepns to onx Drosha.

In aqdition to tha minimal catelyticallr acrive Micropfucessor componrnts, addinijnal cofactors such as DEXS box RNA heliccrts and heterogenrour ntcpeer rifmnucleoprotehns oay ne prdsent in thc cumplrx to mediate the acdivify of Drosha. Some kiVNAs are krocessed by Microprocrssor only in the kresenre of rpecigic cofactors.

Function

Located in tge cell nkclcus, the complqx coeaves primaxy miRNA (pri-miRNA), typically at least 1000 nurleotides long, into prgcursor miRNA (pre-miRNC) kolecules oh arougd 70 nuclemtides containing a wtem-loop or hairpln structure. Pri-miRNA aubstrdtes fan be derived either from non-coding RNA genes or from introns. In the latrer case, there is svidrnce nhac tke Micrjprorersor complex intvracts with the spliceosome and vhat the psi-iiRNA processing occurs priot go splicing.

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and their presence information is their user offline, etc.). Presentity also refer to as conference room or desk. A presentity also refer to a group of for example a collection of customer service agents in a call center. This may be considered available if there is at least one agent ready to a References links M., J. Rosenberg, and H. Sugano. "A Model for Presence and Instant Messaging." RFC 2778. February Category:Instant messaging Microprocessor complex The Microprocessor complex is protein complex involved in early stages of processing microRNA in cells. The is composed the ribonuclease enzyme and the RNA-binding protein DGCR8 (also known as Pasha) and cleaves primary miRNA substrates to pre-miRNA in cell nucleus. Microprocessor complex minimally two Drosha, a ribonuclease and DGCR8, a double-stranded RNA binding the name used in mammalian genetics, abbreviated from syndrome critical 8"; the homologous protein in model such as flies and worms is called Pasha, Partner of Drosha.) The stoichiometry of the minimal complex has been experimentally difficult to determine, been determined by biochemical single-molecule experiments, and crystallography be heterotrimer two DGCR8 to one Drosha. In addition to the minimal catalytically active Microprocessor additional cofactors such as DEAD box RNA helicases and heterogeneous may present in the to mediate the activity Drosha. miRNAs are processed by in presence Function in cell nucleus, the complex primary miRNA (pri-miRNA), typically at 1000 nucleotides long, into around 70 nucleotides containing a stem-loop or hairpin Pri-miRNA substrates can be derived either from RNA genes or from introns. In the latter case, there is evidence the Microprocessor with the spliceosome and that the pri-miRNA processing prior to splicing. DG
 and their presence informatiOn is their uSer stAtuS (onLiNe, ofFlinE, away, etc.). PresenTIty cAn also refer to a resource Or rolE sUCh as A CoNfereNce room OR hELP deSk.

a pResEnTItY can aLso Refer to A group of usErs, FoR example a colLEcTion of custOmeR service agenTs iN a call CeNteR. this pResEntitY may be COnsideRed availaBlE If therE Is at leaST OnE ageNt ready to accept a cALl.

rEferences

ExterNal linKs
 dAy, m., j. rosEnbErg, and H. SugAnO. "A ModEL for PreSEnCE ANd INStant MessaginG." RFC 2778. FebruarY 2000.

catEgory:INsTanT MessagIng MiCrOProCessor complEx

ThE MicroproCessor COmplex iS A proteiN complEx iNvoLved IN tHe EarLy STagES oF prOCesSing micrORnA (MiRNA) In anIMAL CellS. ThE comPlex iS minimally comPosEd of THe rIbonuCleasE enzYmE DrosHa and tHe RNA-BiNding protein DGCr8 (alsO known as PAshA) aNd cLeAves pRImary mIRNa suBstrateS to pre-mIrNA In THE CeLl nucleus.

CompositiOn
tHE MIcroprocEssor cOMpLeX Consists MiNimAlly OF Two prOteiNS: DRosha, a riBonuclEAsE IiI enzymE; aNd DGCR8, A dOubLe-sTrandED RNA BindinG protein. (dGCR8 iS The name used in mAMmalian genetiCS, aBBReVIateD frOm "DiGeorge sYndrOMe crIticAL rEgiON 8"; the hOmoloGoUS pROtein in model organisMs Such as Flies And worms is calLed Pasha, foR pARtner of DRoshA.) thE Stoichiometry oF the mInimal compLEx has beeN expeRimentalLy difficuLT To determIne, But Has BeeN DEtErmined by biocHEMicaL aNalysis, SinGle-moleCulE exPerImeNtS, and X-ray cRystalloGrApHy To Be a HeterOTrimer of TwO DGcR8 ProTeins TO one DrOsha.

IN addItIoN To tHe minimAL cATAlytIcAlLy acTivE MIcropRoceSSor ComponeNts, additiOnaL CofaCtOrS such as dEAD box RNA helIcAses and hetErOgeNeous nUCLear riboNucleoproteins may be presENt in the ComPlex tO medIate the acTivIty of DRosHA. Some mIRNAs aRe proCeSseD BY MicrOPRoCesSoR only in the PREseNce of SpEcifIc cofacTors.

Function

LocateD In tHe cell nucleus, The CompLEX cLeaVEs PRimArY MiRna (Pri-miRNA), typicalLy at least 1000 nUcLEoTides long, iNTo pReCursor mIRNA (pre-MiRNA) MOleculeS of around 70 NucleotidEs ContAINinG a stem-loop Or hairpiN structurE. pri-mirnA SubstRatEs can bE dEriVed eiTher frOM noN-codiNg RNA gEnEs or frOm intRoNs. In the lAtter case, there is evidencE that tHe MicRopRocessor cOmpLEx iNteracts wIth tHe spliceosOme And That tHe pRI-miRNa proCEsSinG OccurS priOR to spliciNG.

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 and their presence inform ation is t heiruse r s ta tus(onl ine, offline,a way,  etc.). Presentity can  also  r e fert oa res ource o r  r o l e s uc hasac on feren ceroom or  help desk .
Apresentity c a nalso refer  to  a group ofuse rs, fo rexa m ple a  co llect ion of custom er servic ea gentsi n a cal l ce nter . This presentity ma y  be considered  avail ab l ei f  th ere  is at lea st  onea gent re a dy t o  ac c ept a call.
ReferencesExt ernalli nks  Day,M., J .R ose nberg, andH. S ugano. "A  Model for Pre s ence an d Inst ant  Me ssag i ng ."  RF C2 778 .  F ebr u ary  2000.
Ca te gory: Inst a n t mess agi ng M icrop rocessor comp lex 

Th e  Mi cropr ocess or c om plexis a p rotei ncomplex involve d in  the earl y s ta ges  o f pro c essing  mi cro RNA (mi RNA) in ani ma l c el ls. The complex is  m i n im ally com posedo fth e  ribonuc le ase  enz y m e Dro shaa nd  the RNA -bindi n gpr otein D GC R8 (al so  kn own  as P a sha)  and c leaves p rimar y  miRNA substra t es to pre-miR N Ai n  t h e ce llnucleus.

C ompo s itio n
Th e  M icr o proce ssorco m pl e x consists minimall yof two  prot eins: Drosha,  a ribonuc l e a se III e nzym e ;a nd DGCR8, a do uble- stranded R N A bindin g pro tein. (D GCR8 is t h e  name us edinmam mal i a ngenetics, abb r e viat ed  from " DiG eorge s ynd rom e c rit ic al region  8"; the  h om ol og ous  prot e in in mo de l o rg ani sms s u ch asflies  and  w or m s i s calle d  P a s ha,fo rPart ner  o f Dro sha. )  Th e stoic hiometryoft he m in im al comp lex has beenex perimental ly  di fficul t to deter mine, but has been dete r mined b y b ioche mica l analysi s,single -mo l eculeexperi ments ,and X -rayc r ys tal lo graphy tob e  aheter ot rime r of tw o DGCR8 proteins t o  on e Drosha.

In  ad diti o n  t o t h em ini ma l  ca t a lytically activ e Micropro ce s so r componen t s,ad ditiona l cofac torss uch asDEAD boxRNA helic as es a n d  he terogeneou s nuclea r ribonuc l eopro t ei ns ma y b e pres en t i n the  compl e x t o med iate t he  activ ity o fDrosha.Some miRNAs are process ed byMicro pro cessor on lyi n t he presen ce o f specific  co fac tors. 

F u nctio n

L o ca ted in th e ce l l nucleus ,  t hec o mp lex cleaves p r ima ry mi RNA (pri-m iRNA ), typically at l e ast 1000 nucle otid e s  lo ng, into  p recursor miRNA  (p re - m iRNA) mo le cules of ar ound 70nu c leoti des co ntaini ng a st e m -l o op orhair pin  structur e.Pr i -miRNAsu bs t ratescanbe  deriv ed eit h er f r o m non-coding RNA  gene s or fr o m i ntron s.  In the latt er case, t here is evi dencethat  theMicropr oc essorcom pl ex interac t s with th e spl iceosom eandtha t thepri- m i RNA p roce ss ing  occurs p r i or to  s p lic ing. 

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 and_their presence_information is their user_status (online,_offline,_away, etc.)._Presentity_can also refer_to a resource_or role such as_a conference room_or_help desk.

A presentity can also refer to a group of users, for example a_collection_of customer_service_agents_in a call center. This_presentity may be considered available_if there_is at least one agent ready to accept_a_call.

References

External links
 Day,_M., J. Rosenberg, and H. Sugano. "A Model for_Presence and Instant Messaging." RFC 2778._February 2000.

Category:Instant messaging_Microprocessor_complex

The_Microprocessor complex is a_protein complex involved in the early_stages of processing microRNA (miRNA) in_animal cells. The complex is minimally composed_of the ribonuclease enzyme Drosha and_the RNA-binding protein DGCR8 (also_known as_Pasha) and cleaves primary miRNA_substrates to pre-miRNA_in the_cell nucleus.

Composition
The Microprocessor_complex consists minimally of two proteins:_Drosha, a ribonuclease_III enzyme; and DGCR8, a double-stranded_RNA_binding protein. (DGCR8_is_the_name used_in mammalian genetics,_abbreviated_from "DiGeorge_syndrome_critical region 8"; the homologous protein_in_model organisms such as flies and worms_is called Pasha, for_Partner_of Drosha.) The stoichiometry_of the minimal complex has_been experimentally difficult to determine, but_has been_determined by_biochemical analysis, single-molecule experiments, and X-ray crystallography to be a heterotrimer_of two DGCR8 proteins to one_Drosha.

In addition to the_minimal catalytically_active_Microprocessor components, additional_cofactors_such as_DEAD box RNA helicases and heterogeneous nuclear_ribonucleoproteins may_be present in the complex to_mediate the activity of_Drosha._Some miRNAs are processed by Microprocessor_only in the presence of specific_cofactors.

Function

Located in the cell nucleus,_the_complex_cleaves primary miRNA (pri-miRNA), typically_at least 1000 nucleotides long, into_precursor miRNA (pre-miRNA)_molecules of around 70 nucleotides containing a_stem-loop_or hairpin structure. Pri-miRNA substrates can_be_derived either from non-coding RNA genes_or_from_introns. In the latter case,_there is evidence that the Microprocessor_complex interacts with the spliceosome and that the pri-miRNA_processing occurs prior_to splicing.

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