It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.
accumulation of a toxic intermediate metabolite
lamotrigine
increased serum lamotrigine levels
lamotrigine
increased serum lamotrigine levels
valproic acid
accumulation of a toxic intermediate metabolite
valproic acid