Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: A quantitative comparison of sRNA-based and protein-based gene
  regulation   Small, non-coding RNAs (sRNAs) play important roles as genetic regulators in
prokaryotes. sRNAs act post-transcriptionally via complementary pairing with
target mRNAs to regulate protein expression. We use a quantitative approach to
compare and contrast sRNAs with conventional transcription factors (TFs) to
better understand the advantages of each form of regulation. In particular, we
calculate the steady-state behavior, noise properties, frequency-dependent gain
(amplification), and dynamical response to large input signals of both forms of
regulation. While the mean steady-state behavior of sRNA-regulated proteins
exhibits a distinctive tunable threshold-linear behavior, our analysis shows
that transcriptional bursting leads to significantly higher intrinsic noise in
sRNA-based regulation than in TF-based regulation in a large range of
expression levels and limits the ability of sRNAs to perform quantitative
signaling. Nonetheless, we find that sRNAs are better than TFs at filtering
noise in input signals. Additionally, we find that sRNAs allow cells to respond
rapidly to large changes in input signals. These features suggest a niche for
sRNAs in allowing cells to transition quickly yet reliably between distinct
states. This functional niche is consistent with the widespread appearance of
sRNAs in stress-response and quasi-developmental networks in prokaryotes.

2
The categories of this paper are: math
33
The categories of this paper are: plasm-ph
16
The categories of this paper are: stat
35
The categories of this paper are: mtrl-th
20
The categories of this paper are: acc-phys
5
The categories of this paper are: gr-qc
36
The categories of this paper are: cmp-lg
6
The categories of this paper are: astro-ph
25
The categories of this paper are: patt-sol
15
The categories of this paper are: nucl-ex
8
The categories of this paper are: hep-ex
32
The categories of this paper are: atom-ph
30
The categories of this paper are: q-alg
1
The categories of this paper are: cs
23
The categories of this paper are: solv-int
21
The categories of this paper are: adap-org