Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Drosophila melanogaster  females prioritise dietary sterols for producing high quality eggs Limiting calories or specific nutrients without malnutrition, otherwise known as dietary restriction (DR), has been shown to extend lifespan across a broad range of taxa. Our recent findings in Drosophila melanogaster show that supplementing flies on macronutrient-rich diets with additional cholesterol can extend lifespan to the same extent as DR. Macronutrient-rich diets drive high levels of egg production and in doing so deplete the mothers of somatic sterols that are essential for survival. Thus, DR may be beneficial for lifespan because it reduces egg production which in turn reduces the mothers demand for sterols. If this is true, mothers must be prioritising their available sterols, whether from the diet or from their own bodies, to sustain high quality egg production. To test this, we measured the quality of eggs laid by mothers fed either cholesterol-sufficient or cholesterol-depleted diets. We found that even when the mothers diet was completely devoid of cholesterol, high quality egg production persisted. Furthermore, we show that sterol-supplemented flies with long lives continue to lay high quality eggs that give rise to healthy offspring. Thus, in our assays, long life does not require a fecundity cost.
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The categories of this paper are: synthetic
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The categories of this paper are: ecology
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The categories of this paper are: bioengineering
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The categories of this paper are: biochemistry
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The categories of this paper are: and
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The categories of this paper are: animal
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The categories of this paper are: biophysics
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The categories of this paper are: scientific
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The categories of this paper are: physiology
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The categories of this paper are: pathology
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The categories of this paper are: molecular
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The categories of this paper are: behavior
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The categories of this paper are: education
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The categories of this paper are: paleontology
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The categories of this paper are: cancer
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The categories of this paper are: cognition