Instruct: Identify the main category of Medrxiv papers based on the titles and abstracts
Query: Faecal shedding models for SARS-CoV-2 RNA amongst hospitalised patients and implications for wastewater-based epidemiology The concentration of SARS-CoV-2 RNA in faeces is not well established, posing challenges for wastewater-based surveillance of COVID-19 and risk assessments of environmental transmission. We develop versatile hierarchical models for faecal RNA shedding and apply them to data collected in six studies. We find that the mean number of gene copies per mL of faeces is 1.9x106 (2.3x105--2.0x108 95% credible interval) amongst hospitalised patients. We find no evidence for a subpopulation of patients who do not shed RNA: limits of quantification can account for negative stool samples. Our models indicate that hospitalised patients represent the tail of the shedding profile with a half-life of 34 hours (28--43 95% credible interval), suggesting that wastewater-based surveillance signals are more indicative of incidence than prevalence and can be a leading indicator of clinical presentation. Shedding amongst inpatients cannot explain high RNA concentrations observed in wastewater, consistent with more abundant shedding during the early infection course.
39
The categories of this paper are: rheumatology
17
The categories of this paper are: informatics
8
The categories of this paper are: epidemiology
72
The categories of this paper are: urology
27
The categories of this paper are: quality
33
The categories of this paper are: physical
5
The categories of this paper are: health
69
The categories of this paper are: palliative
64
The categories of this paper are: ophthalmology
63
The categories of this paper are: pain
15
The categories of this paper are: allergy
41
The categories of this paper are: nephrology
46
The categories of this paper are: therapeutics
32
The categories of this paper are: rehabilitation
70
The categories of this paper are: otolaryngology
56
The categories of this paper are: research