Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Polypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells We show that the RNA-binding protein Polypyrimidine Tract Binding Protein 1 (PTBP1) is dispensable for the development of naive mouse CD8 T cells, but is necessary for the optimal expansion and production of effector molecules by antigen-specific CD8 T cells in vivo. PTBP1 has an essential role in regulating the early events following activation of the naive CD8 T cell leading to IL-2 and TNF production. It is also required to protect activated CD8 T cells from apoptosis. PTBP1 controls alternative splicing of over 400 genes in naive CD8 T cells in addition to regulating the abundance of [~]200 mRNAs. PTBP1 is required for the nuclear accumulation of c-Fos, NFATc2 and NFATc3, but not NFATc1. This selective effect on NFAT proteins correlates with PTBP1-promoted expression of the shorter A{beta}1 isoform and exon 13 skipped A{beta}2 isoform of the catalytic A-subunit of calcineurin phosphatase. These findings reveal a crucial role for PTBP1 in regulating CD8 T cell activation.
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The categories of this paper are: cell
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The categories of this paper are: biophysics
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The categories of this paper are: cancer
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The categories of this paper are: pathology
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The categories of this paper are: plant
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The categories of this paper are: bioengineering
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The categories of this paper are: education
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The categories of this paper are: behavior
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The categories of this paper are: microbiology
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The categories of this paper are: communication
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The categories of this paper are: paleontology
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The categories of this paper are: zoology
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The categories of this paper are: and
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The categories of this paper are: animal
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The categories of this paper are: genomics
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The categories of this paper are: scientific