Instruct: Identify the main category of Medrxiv papers based on the titles and abstracts
Query: Genome-wide association study identifies susceptibility loci for acute myeloid leukemia Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we performed a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identified a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 x 10-8; KMT5B). We also identified a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N=1287) at 6p21.32 (rs3916765; P = 1.51 x 10-10; HLA). Our results inform on AML etiology by identifying putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).
37
The categories of this paper are: aids
58
The categories of this paper are: hematology
20
The categories of this paper are: psychiatry
66
The categories of this paper are: dentistry
27
The categories of this paper are: quality
5
The categories of this paper are: health
7
The categories of this paper are: emergency
32
The categories of this paper are: rehabilitation
11
The categories of this paper are: policy
46
The categories of this paper are: therapeutics
16
The categories of this paper are: immunology
21
The categories of this paper are: psychology
53
The categories of this paper are: pathology
39
The categories of this paper are: rheumatology
1
The categories of this paper are: sports
70
The categories of this paper are: otolaryngology