Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Accounting for correlated horizontal pleiotropy in two-sample Mendelian
  randomization using correlated instrumental variants   Mendelian randomization (MR) is a powerful approach to examine the causal
relationships between health risk factors and outcomes from observational
studies. Due to the proliferation of genome-wide association studies (GWASs)
and abundant fully accessible GWASs summary statistics, a variety of two-sample
MR methods for summary data have been developed to either detect or account for
horizontal pleiotropy, primarily based on the assumption that the effects of
variants on exposure ({\gamma}) and horizontal pleiotropy ({\alpha}) are
independent. This assumption is too strict and can be easily violated because
of the correlated horizontal pleiotropy (CHP). To account for this CHP, we
propose a Bayesian approach, MR-Corr2, that uses the orthogonal projection to
reparameterize the bivariate normal distribution for {\gamma} and {\alpha}, and
a spike-slab prior to mitigate the impact of CHP. We develop an efficient
algorithm with paralleled Gibbs sampling. To demonstrate the advantages of
MR-Corr2 over existing methods, we conducted comprehensive simulation studies
to compare for both type-I error control and point estimates in various
scenarios. By applying MR-Corr2 to study the relationships between pairs in two
sets of complex traits, we did not identify the contradictory causal
relationship between HDL-c and CAD. Moreover, the results provide a new
perspective of the causal network among complex traits. The developed R package
and code to reproduce all the results are available at
https://github.com/QingCheng0218/MR.Corr2.

2
The categories of this paper are: math
24
The categories of this paper are: dg-ga
14
The categories of this paper are: math-ph
27
The categories of this paper are: comp-gas
31
The categories of this paper are: ao-sci
11
The categories of this paper are: hep-lat
4
The categories of this paper are: cond-mat
21
The categories of this paper are: adap-org
15
The categories of this paper are: nucl-ex
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The categories of this paper are: supr-con
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The categories of this paper are: solv-int
26
The categories of this paper are: bayes-an
32
The categories of this paper are: atom-ph
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The categories of this paper are: gr-qc
10
The categories of this paper are: q-bio
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The categories of this paper are: hep-th