Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Multiscale model of primary motor cortex circuits reproduces in vivo cell type-specific dynamics associated with behavior Understanding cortical function requires studying multiple scales: molecular, cellular, circuit and behavior. We developed a biophysically detailed multiscale model of mouse primary motor cortex (M1) with over 10,000 neurons and 30 million synapses. Neuron types, densities, spatial distributions, morphologies, biophysics, connectivity and dendritic synapse locations were tightly constrained by experimental data. The model includes long-range inputs from 7 thalamic and cortical regions, as well as noradrenergic inputs from locus coeruleus. Connectivity depended on cell class and cortical depth at sublaminar resolution. The model accurately predicted in vivo layer- and cell type-specific responses (firing rates and LFP) associated with behavioral states (quiet wakefulness and movement) and experimental manipulations (noradrenaline receptor blocking and thalamus inactivation). It also enabled evaluation of multiple mechanistic hypotheses underlying the observed activity. This quantitative theoretical framework can be used to integrate and interpret M1 experimental data and sheds light on the cell type-specific multiscale dynamics associated with a range of experimental conditions and behaviors.
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The categories of this paper are: genetics
17
The categories of this paper are: molecular
20
The categories of this paper are: pharmacology
16
The categories of this paper are: microbiology
2
The categories of this paper are: biology
14
The categories of this paper are: biophysics
32
The categories of this paper are: zoology
12
The categories of this paper are: behavior
9
The categories of this paper are: synthetic
6
The categories of this paper are: plant
10
The categories of this paper are: and
21
The categories of this paper are: toxicology
28
The categories of this paper are: communication
25
The categories of this paper are: bioengineering
18
The categories of this paper are: systems
5
The categories of this paper are: cell