Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Within host dynamics of SARS-CoV-2 in humans: Modeling immune responses
  and antiviral treatments   In December 2019, a newly discovered SARS-CoV-2 virus was emerged from China
and propagated worldwide as a pandemic. In the absence of preventive medicine
or a ready to use vaccine, mathematical models can provide useful scientific
insights about transmission patterns and targets for drug development. In this
study, we propose a within-host mathematical model of SARS-CoV-2 infection
considering innate and adaptive immune responses. We analyze the equilibrium
points of the proposed model and obtain an expression of the basic reproduction
number. We then numerically show the existence of a transcritical bifurcation.
The proposed model is calibrated to real viral load data of two COVID-19
patients. Using the estimated parameters, we perform global sensitivity
analysis with respect to the peak of viral load. Finally, we study the efficacy
of antiviral drugs and vaccination on the dynamics of SARS-CoV-2 infection. Our
results suggest that blocking the production of the virus by infected cells
decreases the viral load more than reducing the infection rate of healthy
cells. Vaccination is also found useful but during the vaccine development
phase, blocking virus production from infected cells can be targeted for
antiviral drug development.

3
The categories of this paper are: physics
17
The categories of this paper are: q-fin
37
The categories of this paper are: supr-con
12
The categories of this paper are: nucl-th
14
The categories of this paper are: math-ph
1
The categories of this paper are: cs
31
The categories of this paper are: ao-sci
29
The categories of this paper are: funct-an
22
The categories of this paper are: chao-dyn
21
The categories of this paper are: adap-org
34
The categories of this paper are: chem-ph
35
The categories of this paper are: mtrl-th
4
The categories of this paper are: cond-mat
26
The categories of this paper are: bayes-an
6
The categories of this paper are: astro-ph
16
The categories of this paper are: stat