Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Measuring context-dependent memory in rodents: a systematic review and meta-analysis of important variables in the object-in-context task. Environmental information plays an important role in remembering events. Information about stable aspects of the environment (here referred to as  context) and the event are combined by the hippocampal system and stored as context-dependent memory. In rodents (such as rats and mice), context-dependent memory is often investigated with the object-in-context task. However, the implementation and interpretation of this task varies considerably across studies. This variation hampers the comparison between studies and - for those who design a new experiment or carry out pilot experiments - the estimation of whether observed behavior is within the expected range. Also, it is currently unclear which of the variables critically influence the outcome of the task. To address these issues, we carried out a preregistered systematic review (PROSPERO CRD42020191340) and provide an up-to-date overview of the animal-, task-, and protocol-related variations in the object-in-context task for rodents. Using a data-driven explorative meta-analysis we next identified critical factors influencing the outcome of this task, such as sex, testbox size and the delay between the learning trials. Based on these observations we provide recommendations to create more consensus in the set-up, procedure and interpretation of the object-in-context task for rodents. This could contribute to a more robust and evidence-based design in future animal experiments.
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The categories of this paper are: genomics
31
The categories of this paper are: paleontology
32
The categories of this paper are: zoology
11
The categories of this paper are: cognition
3
The categories of this paper are: evolutionary
22
The categories of this paper are: physiology
25
The categories of this paper are: bioengineering
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The categories of this paper are: cell
1
The categories of this paper are: bioinformatics
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The categories of this paper are: pathology
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The categories of this paper are: molecular
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The categories of this paper are: behavior
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The categories of this paper are: and
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The categories of this paper are: education
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The categories of this paper are: scientific
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The categories of this paper are: toxicology