Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Native American Ancestry and Pigmentation Allele Contributions to Skin Color in a Caribbean Population Interest in the genetic basis of variation in skin pigmentation in Native American populations led us to seek indigenous populations of the Western Hemisphere with African and minimal European admixture to study the effect of Native American ancestry on skin color. Admixture analysis from DNA collected from 458 individuals in the Kalinago territory of the Commonwealth of Dominica showed shared ancestry with East Asians at K=3 and 55% Native American, 32% African, and 11% European ancestry at K=6, the highest Native American ancestry of Caribbean populations. Skin pigmentation was 20 to 80 melanin units, averaging 46. Three albino individuals were homozygous for multi-nucleotide polymorphism OCA2NW273KV of African origin, whose population allele frequency was 0.03 and single allele effect size was -8 melanin units. Hypopigmenting allele frequencies for SLC24A5A111T and SLC45A2L374F were 0.14 and 0.05, whose single allele effect sizes were -6 and -3, respectively. Skin color plots of individuals lacking known hypopigmenting alleles suggests that Native American Ancestry reduced pigmentation by more than 20 melanin units (low and high estimates 21.8 and 28.5). Shared ancestry with East Asians at K=3 suggests potential sharing of one or more pigmentation alleles.
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The categories of this paper are: zoology
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The categories of this paper are: systems
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The categories of this paper are: developmental
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The categories of this paper are: evolutionary
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The categories of this paper are: epidemiology
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The categories of this paper are: toxicology
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The categories of this paper are: ecology
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The categories of this paper are: cell
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The categories of this paper are: and
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The categories of this paper are: education
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The categories of this paper are: immunology
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The categories of this paper are: communication
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The categories of this paper are: microbiology
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The categories of this paper are: physiology
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The categories of this paper are: cancer
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The categories of this paper are: behavior