Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Determining the stability of genetic switches: explicitly accounting for
  mRNA noise   Cells use genetic switches to shift between alternate gene expression states,
e.g., to adapt to new environments or to follow a developmental pathway. Here,
we study the dynamics of switching in a generic-feedback on/off switch. Unlike
protein-only models, we explicitly account for stochastic fluctuations of mRNA,
which have a dramatic impact on switch dynamics. Employing the WKB theory to
treat the underlying chemical master equations, we obtain accurate results for
the quasi-stationary distributions of mRNA and protein copy numbers and for the
mean switching time, starting from either state. Our analytical results agree
well with Monte Carlo simulations. Importantly, one can use the approach to
study the effect of varying biological parameters on switch stability.

21
The categories of this paper are: adap-org
19
The categories of this paper are: eess
17
The categories of this paper are: q-fin
35
The categories of this paper are: mtrl-th
9
The categories of this paper are: nlin
36
The categories of this paper are: cmp-lg
16
The categories of this paper are: stat
13
The categories of this paper are: quant-ph
2
The categories of this paper are: math
30
The categories of this paper are: q-alg
22
The categories of this paper are: chao-dyn
7
The categories of this paper are: hep-th
23
The categories of this paper are: solv-int
8
The categories of this paper are: hep-ex
6
The categories of this paper are: astro-ph
18
The categories of this paper are: econ