Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Uncertainty quantification of a thrombosis model considering the
  clotting assay PFA-100   Mathematical models of thrombosis are currently used to study clinical
scenarios of pathological thrombus formation. Most of these models involve
inherent uncertainties that must be assessed to increase the confidence in
model predictions and identify avenues of improvement for both thrombosis
modeling and anti-platelet therapies. In this work, an uncertainty
quantification analysis of a multi-constituent thrombosis model is performed
considering a common assay for platelet function (PFA-100). The analysis is
performed using a polynomial chaos expansion as a parametric surrogate for the
thrombosis model. The polynomial approximation is validated and used to perform
a global sensitivity analysis via computation of Sobol' coefficients. Six out
of fifteen parameters were found to be influential in the simulation
variability considering only individual effects. Nonetheless, parameter
interactions are highlighted when considering the total Sobol' indices. In
addition to the sensitivity analysis, the surrogate model was used to compute
the PFA-100 closure times of 300,000 virtual cases that align well with
clinical data. The current methodology could be used including common
anti-platelet therapies to identify scenarios that preserve the hematological
balance.

0
The categories of this paper are: hep-ph
3
The categories of this paper are: physics
1
The categories of this paper are: cs
4
The categories of this paper are: cond-mat
24
The categories of this paper are: dg-ga
12
The categories of this paper are: nucl-th
28
The categories of this paper are: alg-geom
31
The categories of this paper are: ao-sci
15
The categories of this paper are: nucl-ex
35
The categories of this paper are: mtrl-th
17
The categories of this paper are: q-fin
33
The categories of this paper are: plasm-ph
20
The categories of this paper are: acc-phys
27
The categories of this paper are: comp-gas
6
The categories of this paper are: astro-ph
22
The categories of this paper are: chao-dyn