Instruct: Identify the main category of Medrxiv papers based on the titles and abstracts
Query: Two Pools of ATP Detected in the Brains of Pediatric Patients with Myelin Oligodendrocyte Glycoprotein Antibody Disorders (MOGAD) by 3D 31P MR Spectroscopic Imaging (MRSI) at 7T Over the past four decades, ATP, the obligatory energy molecule for keeping all cells alive and functioning, was thought to contribute only one set of 31P MR signals in the human brain. Here we report for the first time the simultaneous detection of two pools of ATP in the human brain by high-resolution 3D 31P MRSI at ultrahigh field 7T. These two ATP pools differ in cytosolic Mg2+ concentration (1:0.5 ratio), with a resonance separation of 0.5 ppm at {beta}-ATP, a well-established imaging marker of intracellular Mg2+ concentration. Mg2+ is a cofactor of ATPase and its deficiency is associated with immune dysfunction, free radical damage, perturbations in Ca2+ homeostasis, and development of atherosclerosis, dyslipidemia and a number of neurological disorders, such as cerebral vasospasm, stroke, migraine, Alzheimers disease, and Parkinsons disease. Our study documents reduced Mg levels in the brain of patients with myelin oligodendrocyte glycoprotein antibody disorders (MOGAD), which is an idiopathic, inflammatory, demyelinating condition of the central nervous system (CNS) more common in pediatric patients. Low-Mg2+ ATP signals were detected mostly in the white matter regions in MOGAD, suggesting an association between Mg2+ deficiency and compromised functions of oligodendrocytes in maintenance and generation of the axonal myelin sheath. This preliminary study demonstrates the utility of the 7T 3D 31P MSRI for probing altered energy metabolism at reduced availability of Mg2+ rather than ATP itself. The potential correlation between [Mg2+] and disease progression over time should be assessed in larger cohorts.

Author ApprovalYes
58
The categories of this paper are: hematology
21
The categories of this paper are: psychology
32
The categories of this paper are: rehabilitation
23
The categories of this paper are: gastroenterology
19
The categories of this paper are: public
49
The categories of this paper are: intensive
71
The categories of this paper are: ethics
33
The categories of this paper are: physical
48
The categories of this paper are: critical
56
The categories of this paper are: research
43
The categories of this paper are: environmental
26
The categories of this paper are: systems
35
The categories of this paper are: pediatrics
25
The categories of this paper are: improvement
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The categories of this paper are: ophthalmology
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The categories of this paper are: care