Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Nanoplasmonic Tweezers Visualize Protein p53 Suppressing Unzipping of
  Single DNA-Hairpins   Here we report on the use of double-nanohole (DNH) optical tweezers as a
label-free and free-solution single-molecule probe for protein-DNA
interactions. Using this approach, we demonstrate the unzipping of individual
10 base pair DNA-hairpins, and quantify how tumor suppressor p53 protein delays
the unzipping. From the Arrhenius behavior, we find the energy barrier to
unzipping introduced by p53 to be $2\times 10^{-20}$ J, whereas cys135ser
mutant p53 does not show suppression of unzipping, which gives clues to its
functional inability to suppress tumor growth. This transformative approach to
single molecule analysis allows for ultra-sensitive detection and
quantification of protein-DNA interactions to revolutionize the fight against
genetic diseases.

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The categories of this paper are: q-fin
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The categories of this paper are: eess
8
The categories of this paper are: hep-ex
7
The categories of this paper are: hep-th
34
The categories of this paper are: chem-ph
4
The categories of this paper are: cond-mat
12
The categories of this paper are: nucl-th
35
The categories of this paper are: mtrl-th
37
The categories of this paper are: supr-con
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The categories of this paper are: alg-geom
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The categories of this paper are: ao-sci
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The categories of this paper are: chao-dyn
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The categories of this paper are: acc-phys
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The categories of this paper are: solv-int
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The categories of this paper are: dg-ga
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The categories of this paper are: econ