Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: mRNA-miRNA Reciprocal Regulation Enabled Bistable Switch Directs Cell
  Fate Decision   miRNAs serve as crucial post-transcriptional regulators in various essential
cell fate decision. However, the contribution of the mRNA-miRNA mutual
regulation to bistability is not fully understood. Here, we built a set of
mathematical models of mRNA-miRNA interactions and systematically analyzed the
sensitivity of response curves under various conditions. First, we found that
mRNA-miRNA reciprocal regulation could manifest ultrasensitivity to subserve
the generation of bistability when equipped with a positive feedback loop.
Second, the region of bistability is expanded by a stronger competing mRNA
(ceRNA). Interesting, bistability can be emerged without feedback loop if
multiple miRNA binding sites exist on a target mRNA. Thus, we demonstrated the
importance of simple mRNA-miRNA reciprocal regulation in cell fate decision.

14
The categories of this paper are: math-ph
9
The categories of this paper are: nlin
16
The categories of this paper are: stat
31
The categories of this paper are: ao-sci
11
The categories of this paper are: hep-lat
7
The categories of this paper are: hep-th
29
The categories of this paper are: funct-an
13
The categories of this paper are: quant-ph
27
The categories of this paper are: comp-gas
20
The categories of this paper are: acc-phys
33
The categories of this paper are: plasm-ph
30
The categories of this paper are: q-alg
34
The categories of this paper are: chem-ph
36
The categories of this paper are: cmp-lg
15
The categories of this paper are: nucl-ex
6
The categories of this paper are: astro-ph