Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Modeling the microscopic electrical properties of thrombin binding
  aptamer (TBA) for label-free biosensors   Aptamers are chemically produced oligonucleotides, able to bind a variety of
targets such as drugs, proteins and pathogens with high sensitivity and
selectivity. Therefore, aptamers are largely employed for producing label-free
biosensors, with significant applications in diagnostics and drug delivery. In
particular, the anti-thrombin aptamers are biomolecules of high interest for
clinical use, because of their ability to recognize and bind the thrombin
enzyme. Among them, the DNA 15-mer thrombin-binding aptamer (TBA), has been
widely explored concerning both its structure, which was resolved with
different techniques, and its function, especially about the possibility of
using it as the active part of biosensors. This paper proposes a microscopic
model of the electrical properties of TBA and the aptamer-thrombin complex,
combining information from both structure and function. The novelty consists in
describing both the aptamer alone and the complex as an impedance network, thus
going deeper inside the issues addressed in an emerging electronics branch
known as proteotronics. The theoretical results are compared and validated with
Electrochemical Impedance Spectroscopy measurements reported in the literature.
Finally, the model suggests resistance measurements as a novel tool for testing
aptamer-target affinity.

30
The categories of this paper are: q-alg
15
The categories of this paper are: nucl-ex
2
The categories of this paper are: math
19
The categories of this paper are: eess
29
The categories of this paper are: funct-an
24
The categories of this paper are: dg-ga
37
The categories of this paper are: supr-con
13
The categories of this paper are: quant-ph
32
The categories of this paper are: atom-ph
33
The categories of this paper are: plasm-ph
28
The categories of this paper are: alg-geom
35
The categories of this paper are: mtrl-th
22
The categories of this paper are: chao-dyn
7
The categories of this paper are: hep-th
21
The categories of this paper are: adap-org
9
The categories of this paper are: nlin