Instruct: Identify the main category of Medrxiv papers based on the titles and abstracts
Query: City-wide wastewater genomic surveillance through the successive emergence of SARS-CoV-2 Alpha and Delta variants Genomic surveillance of SARS-CoV-2 has been essential to provide an evidence base for public health decisions throughout the SARS-CoV-2 pandemic. Sequencing data from clinical cases has provided data crucial to understanding disease transmission and the detection, surveillance, and containment of outbreaks of novel variants, which continue to pose fresh challenges. However, genomic wastewater surveillance can provide important complementary information by providing estimates of variant frequencies which do not suffer from sampling bias, and capturing all variants circulating in a population. Here we show that genomic SARS-CoV-2 wastewater surveillance can detect fine-scale differences within urban centres, specifically within the city of Liverpool, UK, during the emergence of Alpha and Delta variants between November 2020 and June 2021. Overall, the correspondence between wastewater and clinical variant frequencies demonstrates the reliability of wastewater surveillance. Yet, discrepancies between the two approaches when the Alpha variant was first detected emphasises that wastewater monitoring can also capture missing information resulting from asymptomatic cases or communities less engaged with testing programmes, as found by a simultaneous surge testing effort across the city.
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The categories of this paper are: oncology
53
The categories of this paper are: pathology
0
The categories of this paper are: neurology
39
The categories of this paper are: rheumatology
29
The categories of this paper are: anesthesia
55
The categories of this paper are: obstetrics
21
The categories of this paper are: psychology
35
The categories of this paper are: pediatrics
60
The categories of this paper are: addiction
7
The categories of this paper are: emergency
72
The categories of this paper are: urology
54
The categories of this paper are: gynecology
64
The categories of this paper are: ophthalmology
63
The categories of this paper are: pain
62
The categories of this paper are: orthopedics
70
The categories of this paper are: otolaryngology