Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: MCA: Multiresolution Correlation Analysis, a graphical tool for
  subpopulation identification in single-cell gene expression data   Background: Biological data often originate from samples containing mixtures
of subpopulations, corresponding e.g. to distinct cellular phenotypes. However,
identification of distinct subpopulations may be difficult if biological
measurements yield distributions that are not easily separable. Results: We
present Multiresolution Correlation Analysis (MCA), a method for visually
identifying subpopulations based on the local pairwise correlation between
covariates, without needing to define an a priori interaction scale. We
demonstrate that MCA facilitates the identification of differentially regulated
subpopulations in simulated data from a small gene regulatory network, followed
by application to previously published single-cell qPCR data from mouse
embryonic stem cells. We show that MCA recovers previously identified
subpopulations, provides additional insight into the underlying correlation
structure, reveals potentially spurious compartmentalizations, and provides
insight into novel subpopulations. Conclusions: MCA is a useful method for the
identification of subpopulations in low-dimensional expression data, as
emerging from qPCR or FACS measurements. With MCA it is possible to investigate
the robustness of covariate correlations with respect subpopulations,
graphically identify outliers, and identify factors contributing to
differential regulation between pairs of covariates. MCA thus provides a
framework for investigation of expression correlations for genes of interests
and biological hypothesis generation.

31
The categories of this paper are: ao-sci
11
The categories of this paper are: hep-lat
21
The categories of this paper are: adap-org
6
The categories of this paper are: astro-ph
36
The categories of this paper are: cmp-lg
33
The categories of this paper are: plasm-ph
18
The categories of this paper are: econ
4
The categories of this paper are: cond-mat
28
The categories of this paper are: alg-geom
32
The categories of this paper are: atom-ph
8
The categories of this paper are: hep-ex
34
The categories of this paper are: chem-ph
30
The categories of this paper are: q-alg
3
The categories of this paper are: physics
9
The categories of this paper are: nlin
37
The categories of this paper are: supr-con