Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Integration of Clinical, Biological, and Computational Perspectives to
  Support Cerebral Autoregulatory Informed Clinical Decision Making Decomposing
  Cerebral Autoregulation using Mechanistic Timescales to Support Clinical
  Decision-Making   Adequate brain perfusion is required for proper brain function and life.
Maintaining optimal brain perfusion to avoid secondary brain injury is one of
the main concerns of neurocritical care. Cerebral autoregulation is responsible
for maintaining optimal brain perfusion despite pressure derangements.
Knowledge of cerebral autoregulatory function should be a key factor in
clinical decision-making, yet it is often insufficiently and incorrectly
applied. Multiple physiologic mechanisms impact cerebral autoregulation, each
of which operate on potentially different and incompletely understood
timescales confounding conclusions drawn from observations. Because of such
complexities, clinical conceptualization of cerebral autoregulation has been
distilled into practical indices defined by multimodal neuromonitoring, which
removes mechanistic information and limits decision options. The next step
towards cerebral autoregulatory-informed clinical decision-making is to
quantify cerebral autoregulation mechanistically, which requires decomposing
cerebral autoregulation into its fundamental processes and partitioning those
processes into the timescales at which each operates. In this review, we
scrutinize biologically, clinically, and computationally focused literature to
build a timescales-based framework around cerebral autoregulation. This new
framework will allow us to quantify mechanistic interactions and directly infer
which mechanism(s) are functioning based only on current monitoring equipment,
paving the way for a new frontier in cerebral autoregulatory-informed clinical
decision-making.

15
The categories of this paper are: nucl-ex
5
The categories of this paper are: gr-qc
26
The categories of this paper are: bayes-an
8
The categories of this paper are: hep-ex
34
The categories of this paper are: chem-ph
9
The categories of this paper are: nlin
6
The categories of this paper are: astro-ph
1
The categories of this paper are: cs
28
The categories of this paper are: alg-geom
11
The categories of this paper are: hep-lat
12
The categories of this paper are: nucl-th
37
The categories of this paper are: supr-con
4
The categories of this paper are: cond-mat
23
The categories of this paper are: solv-int
24
The categories of this paper are: dg-ga
30
The categories of this paper are: q-alg