Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Upregulation of DNA repair genes and cell extrusion underpin the remarkable radiation resistance of Trichoplax adhaerens. Trichoplax adhaerens is the simplest multicellular animal with tissue differentiation and somatic cell turnover. Like all other multicellular organisms, it should be vulnerable to cancer, yet there have been no reports of cancer in T. adhaerens, or any other placozoan. We investigated the cancer resistance of T. adhaerens, discovering that they are able to tolerate high levels of radiation damage (218.6 Gy). To investigate how T. adhaerens survive levels of radiation that are lethal to other animals, we examined gene expression after the X-ray exposure, finding overexpression of genes involved in DNA repair and apoptosis including the MDM2 gene. We also discovered that T. adhaerens extrudes clusters of inviable cells after X-ray exposure. T. adhaerens is a valuable model organism for studying the molecular, genetic and tissue-level mechanisms underlying cancer suppression.
5
The categories of this paper are: cell
28
The categories of this paper are: communication
17
The categories of this paper are: molecular
1
The categories of this paper are: bioinformatics
23
The categories of this paper are: immunology
3
The categories of this paper are: evolutionary
26
The categories of this paper are: biochemistry
21
The categories of this paper are: toxicology
29
The categories of this paper are: education
6
The categories of this paper are: plant
14
The categories of this paper are: biophysics
31
The categories of this paper are: paleontology
19
The categories of this paper are: epidemiology
11
The categories of this paper are: cognition
4
The categories of this paper are: neuroscience
8
The categories of this paper are: genomics