Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Network medicine in ovarian cancer: Topological properties to drug
  discovery   The investigation of topological properties of ovarian cancer network (OCN)
and the roles of hubs involved in it by digging the network at various levels
of organization are important to understand how OCN is organized to understand
disease states. The OCN constructed from the experimentally verified genes
exhibits fractal nature in the topological properties of the network and deeply
rooted communities. Also, the network properties at all levels of organization
obey one parameter scaling law which lacks centrality lethality rule. We then
showed that $\langle k\rangle$ can be taken as a scaling parameter, where,
power law exponent can be estimated from the ratio of network diameters,
$\lambda=1+\rho\left[\frac{d_c}{d_k}\right]$. The betweenness centrality shows
two distinct behaviors one shown by high degree hubs and the other by
segregated low degree nodes. The $C_B$ distribution follows power law behavior
with the exponent connected to exponents of distributions of high and low
degree nodes by,
$\theta\sim\left[1+\frac{1}{2}\left(\frac{1}{\epsilon_s}+\frac{1}{\epsilon_h}\right)(\lambda-1)\right]$.
Absence of rich-club formation leads to the missing of a number of attractors
in the network causing formation of weakly tied diverse functional modules to
keep optimal network efficiency. The hubs knockout experiment shows that
provincial hubs take major responsibility to keep network integrity and
organization. The identified key regulators are found to be provincial and
connector hubs. Further, two key regulators, EPCAM and CD44 are found to be
maximally over expressed at various cancer stages (II-IV). They are also
positively correlated with immune infiltrates (CD4+ T cells). Finally, few
potential drugs are identified related to the key regulators.

37
The categories of this paper are: supr-con
15
The categories of this paper are: nucl-ex
34
The categories of this paper are: chem-ph
22
The categories of this paper are: chao-dyn
6
The categories of this paper are: astro-ph
0
The categories of this paper are: hep-ph
16
The categories of this paper are: stat
36
The categories of this paper are: cmp-lg
18
The categories of this paper are: econ
1
The categories of this paper are: cs
24
The categories of this paper are: dg-ga
27
The categories of this paper are: comp-gas
11
The categories of this paper are: hep-lat
29
The categories of this paper are: funct-an
28
The categories of this paper are: alg-geom
12
The categories of this paper are: nucl-th