Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Population-Based Black-Box Optimization for Biological Sequence Design   The use of black-box optimization for the design of new biological sequences
is an emerging research area with potentially revolutionary impact. The cost
and latency of wet-lab experiments requires methods that find good sequences in
few experimental rounds of large batches of sequences--a setting that
off-the-shelf black-box optimization methods are ill-equipped to handle. We
find that the performance of existing methods varies drastically across
optimization tasks, posing a significant obstacle to real-world applications.
To improve robustness, we propose Population-Based Black-Box Optimization
(P3BO), which generates batches of sequences by sampling from an ensemble of
methods. The number of sequences sampled from any method is proportional to the
quality of sequences it previously proposed, allowing P3BO to combine the
strengths of individual methods while hedging against their innate brittleness.
Adapting the hyper-parameters of each of the methods online using evolutionary
optimization further improves performance. Through extensive experiments on
in-silico optimization tasks, we show that P3BO outperforms any single method
in its population, proposing higher quality sequences as well as more diverse
batches. As such, P3BO and Adaptive-P3BO are a crucial step towards deploying
ML to real-world sequence design.

22
The categories of this paper are: chao-dyn
20
The categories of this paper are: acc-phys
15
The categories of this paper are: nucl-ex
5
The categories of this paper are: gr-qc
18
The categories of this paper are: econ
12
The categories of this paper are: nucl-th
35
The categories of this paper are: mtrl-th
2
The categories of this paper are: math
31
The categories of this paper are: ao-sci
36
The categories of this paper are: cmp-lg
6
The categories of this paper are: astro-ph
24
The categories of this paper are: dg-ga
17
The categories of this paper are: q-fin
13
The categories of this paper are: quant-ph
7
The categories of this paper are: hep-th
33
The categories of this paper are: plasm-ph