Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Reduced Dimensionality tailored HN(C)N Pulse Sequences for Efficient
  Backbone Resonance Assignment of Proteins through Rapid Identification of
  Sequential HSQC peaks   Two novel reduced dimensionality (RD) experiments -(4,3)D-hNCOcaNH and
(4,3)D-hNcoCANH- have been presented here to facilitate the backbone resonance
assignment of proteins both in terms of its accuracy and speed. The experiments
basically represent an improvisation of previously reported HN(C)N experiment
[Panchal et. al., J. Biomol. NMR. (2002), 20 (2), 135-147] and exploit the
simple reduced dimensionality NMR concept [Szyperski et. al. (2002), Proc.
Natl. Acad. Sci. U.S.A. 99(12), 8009-8014] to achieve (a) higher dispersion and
resolution along the co-evolved F1 dimension and (b) rapid identification of
sequential HSQC peaks on its F2(15N)- F3(1H) planes. The current implementation
is based on the fact that the linear combination of 15N and 13CO/13Ca chemical
shifts offers relatively better dispersion and randomness compared to the
individual chemical shifts; thus enables the assignment of crowded HSQC spectra
by resolving the ambiguities generally encountered in HNCN based assignment
protocol because of amide 15N shift degeneracy. Additionally, each of these
experiments enables assignment of backbone 13CO/13Ca resonances as well.
Overall, the reduced dimensionality tailored HNCN experiments presented here
will be of immense value for various structural and functional proteomics
studies by NMR; particularly of intrinsically or partially/unstructured
proteins and medium sized (MW ~12-15 kDa) folded proteins. The experiments,
like any other experiment that yields protein assignments, would be extremely
valuable for protein folding and drug discovery programs as well.

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The categories of this paper are: nucl-ex
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The categories of this paper are: funct-an
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The categories of this paper are: stat
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The categories of this paper are: ao-sci
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The categories of this paper are: atom-ph
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The categories of this paper are: math-ph
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The categories of this paper are: nucl-th
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The categories of this paper are: acc-phys
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The categories of this paper are: solv-int
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The categories of this paper are: dg-ga
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The categories of this paper are: nlin
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The categories of this paper are: alg-geom
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The categories of this paper are: hep-ex
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The categories of this paper are: patt-sol
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The categories of this paper are: econ
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The categories of this paper are: math