Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Transscleral Optical Phase Imaging of the Human Retina - TOPI   The in vivo observation of the human retina at the cellular level is crucial
to detect lesions before irreversible visual loss occurs, to follow the time
course of retinal diseases and to evaluate and monitor the early effects of
treatments. Despite the phenomenal advances in optical coherence tomography
(OCT) and adaptive optics systems, in vivo imaging of several retinal cells is
still elusive. Here we propose a radically different method compared to OCT,
called transscleral optical phase imaging (TOPI), which allows to image retinal
cells with high contrast, high resolution, and within an acquisition time
suitable for clinical use. TOPI relies on high-angle oblique illumination of
the retina, combined with adaptive optics, to enhance the phase contrast of
transparent cells. We first present in-vivo images of retinal cells, from the
retinal pigment epithelium (RPE) to the nerve and vascular layers of the
retina, in eleven healthy volunteers without pupil dilation. The morphology of
the cells in vivo is then compared to that of images obtained with the same
technique applied on ex vivo human RPE and pig retinas. Finally, we demonstrate
the ability of high resolution phase microscopy to image pericytes and
microglia around rat retinal capillaries. Our results show the ability of TOPI
to image and quantify retinal cells up to the RPE depth within a maximum time
of 9 seconds over a field of view of 4.4 x 4.4{\deg}, opening new avenue in the
in vivo exploration of the deepest layer of the retina in healthy and diseased
eyes.

15
The categories of this paper are: nucl-ex
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The categories of this paper are: eess
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The categories of this paper are: comp-gas
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The categories of this paper are: solv-int
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The categories of this paper are: hep-lat
4
The categories of this paper are: cond-mat
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The categories of this paper are: mtrl-th
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The categories of this paper are: gr-qc
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The categories of this paper are: hep-ex
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The categories of this paper are: stat
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The categories of this paper are: nlin
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The categories of this paper are: acc-phys
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The categories of this paper are: supr-con
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The categories of this paper are: q-bio
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The categories of this paper are: cmp-lg
2
The categories of this paper are: math