Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate
  Intracellular Activity in Neuronal and Cardiac Networks   Intracellular access with high spatiotemporal resolution can enhance our
understanding of how neurons or cardiomyocytes regulate and orchestrate network
activity, and how this activity can be affected with pharmacology or other
interventional modalities. Nanoscale devices often employ electroporation to
transiently permeate the cell membrane and record intracellular potentials,
which tend to decrease rapidly to extracellular potential amplitudes with time.
Here, we report innovative scalable, vertical, ultra-sharp nanowire arrays that
are individually addressable to enable long-term, native recordings of
intracellular potentials. We report large action potential amplitudes that are
indicative of intracellular access from 3D tissue-like networks of neurons and
cardiomyocytes across recording days and that do not decrease to extracellular
amplitudes for the duration of the recording of several minutes. Our findings
are validated with cross-sectional microscopy, pharmacology, and electrical
interventions. Our experiments and simulations demonstrate that individual
electrical addressability of nanowires is necessary for high-fidelity
intracellular electrophysiological recordings. This study advances our
understanding of and control over high-quality multi-channel intracellular
recordings, and paves the way toward predictive, high-throughput, and low-cost
electrophysiological drug screening platforms.

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The categories of this paper are: gr-qc
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The categories of this paper are: cmp-lg
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The categories of this paper are: hep-ex
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The categories of this paper are: chem-ph
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The categories of this paper are: math-ph
11
The categories of this paper are: hep-lat
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The categories of this paper are: hep-th
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The categories of this paper are: alg-geom
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The categories of this paper are: bayes-an
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The categories of this paper are: q-alg
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The categories of this paper are: nucl-th
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The categories of this paper are: ao-sci
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The categories of this paper are: atom-ph
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The categories of this paper are: hep-ph
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The categories of this paper are: math
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The categories of this paper are: eess