Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation Streptomyces are among the most prolific bacterial producers of specialized metabolites, including antibiotics. The linear chromosome is partitioned into a central region harboring core genes and two extremities enriched in specialized metabolite biosynthetic gene clusters (SMBGCs). The molecular mechanisms governing structure and function of these compartmentalized genomes remain mostly unknown. Here we show that in exponential phase, chromosome structure correlates with genetic compartmentalization: conserved, large and highly transcribed genes form boundaries that segment the central part of the chromosome into domains, whereas the terminal ends are transcriptionally, largely quiescent compartments with different structural features. Onset of metabolic differentiation is accompanied by remodeling of chromosome architecture from an  open to a rather  closed conformation, in which the SMBGCs are expressed forming new boundaries. Altogether, our results reveal that S. ambofaciens linear chromosome is partitioned into structurally distinct entities, indicating a link between chromosome folding, gene expression and genome evolution.
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The categories of this paper are: cognition
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The categories of this paper are: ecology
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The categories of this paper are: immunology
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The categories of this paper are: synthetic
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The categories of this paper are: animal
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The categories of this paper are: biochemistry
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The categories of this paper are: plant
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The categories of this paper are: behavior
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The categories of this paper are: epidemiology
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The categories of this paper are: biology
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The categories of this paper are: paleontology
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The categories of this paper are: biophysics
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The categories of this paper are: physiology
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The categories of this paper are: zoology
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The categories of this paper are: molecular
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The categories of this paper are: neuroscience