Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Photodynamically Active Electrospun Fibres for Antibiotic-Free Infection
  Control   Antimicrobial biomaterials are critical to aid in the regeneration of oral
soft tissue and prevent or treat localised bacterial infections. With the
rising trend in antibiotic resistance, there is a pressing clinical need for
new antimicrobial chemistries and biomaterial design approaches enabling
on-demand activation of antibiotic-free antimicrobial functionality following
an infection that are environment-friendly, flexible and commercially-viable.
This study explores the feasibility of integrating a bioresorbable electrospun
polymer scaffold with localised antimicrobial photodynamic therapy (aPDT)
capability. To enable aPDT, we encapsulated a photosensitiser (PS) in polyester
fibres in the PS inert state, so that the antibacterial function would be
activated on-demand via a visible light source. Fibrous scaffolds were
successfully electrospun from FDA-approved polyesters, either
poly(epsilon-caprolactone (PCL) or poly[(rac-lactide)-co-glycolide] (PLGA) with
encapsulated PS (either methylene blue (MB) or erythrosin B (ER)). The
electrospun fibres achieved an ~100 wt.% loading efficiency of PS, which
significantly increased their tensile modulus and reduced their average fibre
diameter and pore size with respect to PS-free controls. In vitro, PS release
varied between a burst release profile to limited release within 100 hours
depending on the selected scaffold formulation. Exposure of PS-encapsulated PCL
fibres to visible light successfully led to at least a 1 log reduction in E.
coli viability after 60 minutes of light exposure whereas PS-free electrospun
controls did not inactive microbes. This study successfully demonstrates the
significant potential of PS-encapsulated electrospun fibres as photodynamically
active biomaterial for antibiotic-free infection control.

35
The categories of this paper are: mtrl-th
22
The categories of this paper are: chao-dyn
20
The categories of this paper are: acc-phys
25
The categories of this paper are: patt-sol
11
The categories of this paper are: hep-lat
21
The categories of this paper are: adap-org
32
The categories of this paper are: atom-ph
36
The categories of this paper are: cmp-lg
4
The categories of this paper are: cond-mat
1
The categories of this paper are: cs
19
The categories of this paper are: eess
37
The categories of this paper are: supr-con
29
The categories of this paper are: funct-an
7
The categories of this paper are: hep-th
26
The categories of this paper are: bayes-an
34
The categories of this paper are: chem-ph