Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: A minimal model of plasma membrane heterogeneity requires coupling
  cortical actin to criticality   We present a minimal model of plasma membrane heterogeneity that combines
criticality with connectivity to cortical cytoskeleton. Our model is motivated
by recent observations of micron-sized critical fluctuations in plasma membrane
vesicles that are detached from their cortical cytoskeleton. We incorporate
criticality using a conserved order parameter Ising model coupled to a simple
actin cytoskeleton interacting through point-like pinning sites. Using this
minimal model, we recapitulate several experimental observations of plasma
membrane raft heterogeneity. Small (r~20nm) and dynamic fluctuations at
physiological temperatures arise from criticality. Including connectivity to
cortical cytoskeleton disrupts large fluctuations, prevents macroscopic phase
separation at low temperatures (T<=22{\deg}C), and provides a template for long
lived fluctuations at physiological temperature (T=37{\deg}C).
Cytoskeleton-stabilized fluctuations produce significant barriers to the
diffusion of some membrane components in a manner that is weakly dependent on
the number of pinning sites and strongly dependent on criticality. More
generally, we demonstrate that critical fluctuations provide a physical
mechanism to organize and spatially segregate membrane components by providing
channels for interaction over large distances.

14
The categories of this paper are: math-ph
0
The categories of this paper are: hep-ph
37
The categories of this paper are: supr-con
9
The categories of this paper are: nlin
5
The categories of this paper are: gr-qc
12
The categories of this paper are: nucl-th
33
The categories of this paper are: plasm-ph
15
The categories of this paper are: nucl-ex
7
The categories of this paper are: hep-th
18
The categories of this paper are: econ
19
The categories of this paper are: eess
6
The categories of this paper are: astro-ph
13
The categories of this paper are: quant-ph
34
The categories of this paper are: chem-ph
26
The categories of this paper are: bayes-an
28
The categories of this paper are: alg-geom