Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Arginine induced Streptococcus gordonii biofilm detachment using a novel rotating-disc rheometry method Oral diseases are one of the most common pathologies affecting human health. These diseases are typically associated with dental plaque-biofilms, through either build-up of the biofilm or dysbiosis of the microbial community. Arginine can disrupt dental plaque-biofilms, and maintain plaque homeostasis, making it an ideal therapeutic to combat the development of oral disease. Despite our understanding of the actions of arginine towards dental plaque-biofilms, it is still unclear how or if arginine effects the mechanical integrity of the dental plaque-biofilm. Here we adapted a rotating-disc rheometry assay, which is routinely used in marine microbial ecology, to study how arginine treatment of Streptococcus gordonii biofilms influences biofilm detachment from surfaces. We demonstrate that the assay is highly sensitive at quantifying the presence of biofilm and the detachment or rearrangement of the biofilm structure as a function of shear stress. We demonstrate that arginine treatment leads to earlier detachment of the biofilm, indicating that arginine treatment weakens the biofilm, making it more suspectable to removal by shear stresses. Our results add to the understanding that arginine targets biofilms by multifaceted mechanisms, both metabolic and physical, further promoting the potential of arginine as an active compound in dentifrices to maintain oral health.
19
The categories of this paper are: epidemiology
30
The categories of this paper are: scientific
27
The categories of this paper are: pathology
10
The categories of this paper are: and
12
The categories of this paper are: behavior
15
The categories of this paper are: developmental
29
The categories of this paper are: education
32
The categories of this paper are: zoology
0
The categories of this paper are: genetics
8
The categories of this paper are: genomics
28
The categories of this paper are: communication
6
The categories of this paper are: plant
20
The categories of this paper are: pharmacology
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The categories of this paper are: ecology
5
The categories of this paper are: cell
23
The categories of this paper are: immunology