Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Clonal dissection of immunodominance and cross-reactivity of the CD4+ T cell response to SARS-CoV-2 The identification of CD4+ T cell epitopes is essential for the design of effective vaccines capable of inducing neutralizing antibodies and long-term immunity. Here we demonstrate in COVID-19 patients a robust CD4+ T cell response to naturally processed SARS-CoV-2 Spike and Nucleoprotein, including effector, helper and memory T cells. By characterizing 2,943 Spike-reactive T cell clones, we found that 34% of the clones and 93% of the patients recognized a conserved immunodominant region encompassing residues S346-365 in the RBD and comprising three nested HLA-DR and HLA-DP restricted epitopes. By using pre- and post-COVID-19 samples and Spike proteins from alpha and beta coronaviruses, we provide in vivo evidence of cross-reactive T cell responses targeting multiple sites in the SARS-CoV-2 Spike protein. The possibility of leveraging immunodominant and cross-reactive T helper epitopes is instrumental for vaccination strategies that can be rapidly adapted to counteract emerging SARS-CoV-2 variants.
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The categories of this paper are: scientific
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The categories of this paper are: zoology
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The categories of this paper are: developmental
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The categories of this paper are: ecology
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The categories of this paper are: physiology
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The categories of this paper are: behavior
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The categories of this paper are: cell
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The categories of this paper are: pharmacology
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The categories of this paper are: genomics
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The categories of this paper are: paleontology
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The categories of this paper are: cancer
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The categories of this paper are: microbiology
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The categories of this paper are: bioengineering
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The categories of this paper are: genetics
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The categories of this paper are: systems
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The categories of this paper are: synthetic