Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Functional network topography of the medial entorhinal cortex The medial entorhinal cortex (MEC) creates a map of local space, based on the firing patterns of grid, head direction (HD), border, and object-vector (OV) cells. How these cell types are organized anatomically is debated. In-depth analysis of this question requires collection of precise anatomical and activity data across large populations of neurons during unrestrained behavior, which neither electrophysiological nor previous imaging methods fully afford. Here we examined the topographic arrangement of spatially modulated neurons in MEC and adjacent parasubiculum using miniaturized, portable two-photon microscopes, which allow mice to roam freely in open fields. Grid cells exhibited low levels of co-occurrence with OV cells and clustered anatomically, while border, HD and OV cells tended to intermingle. These data suggest that grid-cell networks might be largely distinct from those of border, HD and OV cells and that grid cells exhibit strong coupling among themselves but weaker links to other cell types.

Highlights- Grid and object vector cells show low levels of regional co-occurrence
- Grid cells exhibit the strongest tendency to cluster among all spatial cell types
- Grid cells stay separate from border, head direction and object vector cells
- The territories of grid, head direction and border cells remain stable over weeks
24
The categories of this paper are: cancer
31
The categories of this paper are: paleontology
28
The categories of this paper are: communication
1
The categories of this paper are: bioinformatics
25
The categories of this paper are: bioengineering
15
The categories of this paper are: developmental
26
The categories of this paper are: biochemistry
17
The categories of this paper are: molecular
32
The categories of this paper are: zoology
7
The categories of this paper are: ecology
14
The categories of this paper are: biophysics
29
The categories of this paper are: education
5
The categories of this paper are: cell
19
The categories of this paper are: epidemiology
10
The categories of this paper are: and
23
The categories of this paper are: immunology