Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Identification and characterization of unique to human regulatory
  sequences in embryonic stem cells reveal associations with transposable
  elements, distal enhancers, non-coding RNA, and DNA methylation-driven
  mechanisms of genome editing   Despite significant progress in structural and functional characterization of
human genome, understanding of mechanisms underlying the genetic basis of human
phenotypic uniqueness remains limited. We report that non-randomly distributed
transposable element-derived sequences, most notably HERV-H/LTR7 and L1HS, are
associated with creation of 99.8% unique to human transcription factor binding
sites in genome of embryonic stem cells (ESC). 4,094 unique to human regulatory
loci display selective and site-specific binding of critical regulators (NANOG,
POU5F1, CTCF, Lamin B1) and are preferentially placed within the matrix of
transcriptionally active DNA segments hyper-methylated in ESC. Unique to human
NANOG-binding sites are enriched near the rapidly evolving in primates
protein-coding genes regulating brain size, pluripotency lncRNAs, hESC
enhancers, and 5-hydroxymethylcytosine-harboring regions immediately adjacent
to binding sites. We propose a proximity placement model explaining how 33-47%
excess of NANOG and POU5F1 proteins immobilized on a DNA scaffold may play a
functional role at distal regulatory elements.

28
The categories of this paper are: alg-geom
37
The categories of this paper are: supr-con
13
The categories of this paper are: quant-ph
19
The categories of this paper are: eess
27
The categories of this paper are: comp-gas
4
The categories of this paper are: cond-mat
9
The categories of this paper are: nlin
20
The categories of this paper are: acc-phys
3
The categories of this paper are: physics
5
The categories of this paper are: gr-qc
1
The categories of this paper are: cs
15
The categories of this paper are: nucl-ex
6
The categories of this paper are: astro-ph
36
The categories of this paper are: cmp-lg
8
The categories of this paper are: hep-ex
29
The categories of this paper are: funct-an