Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Mechanistic model for human brain metabolism and the neurovascular coupling. The neurovascular coupling (NVC) connects cerebral activity, blood flow, and metabolism. This interconnection is used in for instance functional imaging, which analyses the blood-oxygen-dependent (BOLD) signal. The mechanisms underlying the NVC are complex, which warrants a model-based analysis of data. We have previously developed a mechanistically detailed model for the NVC, and others have proposed detailed models for cerebral metabolism. However, existing metabolic models are still not fully utilizing available magnetic resonance spectroscopy (MRS) data and are not connected to detailed models for NVC. Therefore, we herein present a new model that integrates mechanistic modelling of both MRS and BOLD data. The metabolic model covers central metabolism, and can describe time-series data for glucose, lactate, aspartate, and glutamine, measured after visual stimuli. Statistical tests confirm that the model can describe both estimation data and predict independent validation data, not used for model training. The interconnected NVC model can simultaneously describe BOLD data and can be used to predict expected metabolic responses in experiments where metabolism has not been measured. This model is a step towards a useful and mechanistically detailed model for cerebral blood flow and metabolism, with potential applications in both basic research and clinical applications.
19
The categories of this paper are: epidemiology
26
The categories of this paper are: biochemistry
1
The categories of this paper are: bioinformatics
32
The categories of this paper are: zoology
27
The categories of this paper are: pathology
28
The categories of this paper are: communication
29
The categories of this paper are: education
15
The categories of this paper are: developmental
22
The categories of this paper are: physiology
12
The categories of this paper are: behavior
8
The categories of this paper are: genomics
17
The categories of this paper are: molecular
23
The categories of this paper are: immunology
4
The categories of this paper are: neuroscience
0
The categories of this paper are: genetics
21
The categories of this paper are: toxicology