Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Signatures of Mechanosensitive Gating   The question of how mechanically-gated membrane channels open and close is
notoriously difficult to address, especially if the protein structure is not
available. This perspective highlights the relevance of micropipette-aspirated
single-particle tracking--- used to obtain a channel's diffusion coefficient,
$D$, as a function of applied membrane tension, $\sigma$--- as an indirect
assay for determining functional behaviour in mechanosensitive channels. Whilst
ensuring that the protein remains integral to the membrane, such methods can be
used to identify not only the gating mechanism of a protein, but also
associated physical moduli, such as torsional- and dilational-rigidity, which
correspond to the protein's effective shape change. As an example, three
distinct $D$ versus $\sigma$ "signatures" are calculated, corresponding to
gating by dilation, gating by tilt, and a combination of both dilation and
tilt. Both advantages and disadvantages of the approach are discussed.

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The categories of this paper are: cmp-lg
6
The categories of this paper are: astro-ph
7
The categories of this paper are: hep-th
8
The categories of this paper are: hep-ex
33
The categories of this paper are: plasm-ph
34
The categories of this paper are: chem-ph
17
The categories of this paper are: q-fin
9
The categories of this paper are: nlin
26
The categories of this paper are: bayes-an
14
The categories of this paper are: math-ph
28
The categories of this paper are: alg-geom
31
The categories of this paper are: ao-sci
12
The categories of this paper are: nucl-th
18
The categories of this paper are: econ
10
The categories of this paper are: q-bio
35
The categories of this paper are: mtrl-th