Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Broad-spectrum in vitro antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified monophosphate prodrug of remdesivir parent nucleoside (GS-441524) The intravenous administration of remdesivir for COVID-19 confines its utility to hospitalized patients. We evaluated the broad-spectrum antiviral activity of ODBG-P-RVn, an orally available, lipid-modified monophosphate prodrug of the remdesivir parent nucleoside (GS-441524) against viruses that cause diseases of human public health concern, including SARS-CoV-2. ODBG-P-RVn showed 20-fold greater antiviral activity than GS-441524 and had near-equivalent activity to remdesivir in primary-like human small airway epithelial cells. Our results warrant investigation of ODBG-P-RVn efficacy in vivo.
17
The categories of this paper are: molecular
12
The categories of this paper are: behavior
9
The categories of this paper are: synthetic
2
The categories of this paper are: biology
15
The categories of this paper are: developmental
3
The categories of this paper are: evolutionary
7
The categories of this paper are: ecology
13
The categories of this paper are: animal
30
The categories of this paper are: scientific
4
The categories of this paper are: neuroscience
24
The categories of this paper are: cancer
0
The categories of this paper are: genetics
8
The categories of this paper are: genomics
1
The categories of this paper are: bioinformatics
31
The categories of this paper are: paleontology
32
The categories of this paper are: zoology