Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: ENCODING OF LIMB STATE BY SINGLE NEURONS IN THE CUNEATE NUCLEUS OF AWAKE MONKEYS The cuneate nucleus (CN) is among the first sites along the neuraxis where proprioceptive signals can be integrated, transformed, and modulated. The objective of the study was to characterize the proprioceptive representations in CN. To this end, we recorded from single CN neurons in three monkeys during active reaching and passive limb perturbation. We found that many neurons exhibited responses that were tuned approximately sinusoidally to limb movement direction, as has been found for other sensorimotor neurons. The distribution of their preferred directions (PDs) was highly non-uniform and resembled that of muscle spindles within individual muscles, suggesting that CN neurons typically receive inputs from only a single muscle. We also found that the responses of proprioceptive CN neurons tended to be modestly amplified during active reaching movements compared to passive limb perturbations, in contrast to cutaneous CN neurons whose responses were not systematically different in the active and passive conditions. Somatosensory signals thus seem to be subject to a "spotlighting" of relevant sensory information rather than uniform suppression as has been suggested previously.
7
The categories of this paper are: ecology
3
The categories of this paper are: evolutionary
19
The categories of this paper are: epidemiology
20
The categories of this paper are: pharmacology
27
The categories of this paper are: pathology
30
The categories of this paper are: scientific
21
The categories of this paper are: toxicology
32
The categories of this paper are: zoology
15
The categories of this paper are: developmental
28
The categories of this paper are: communication
24
The categories of this paper are: cancer
10
The categories of this paper are: and
5
The categories of this paper are: cell
23
The categories of this paper are: immunology
13
The categories of this paper are: animal
17
The categories of this paper are: molecular