Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Host-parasite coevolution promotes innovation through deformations in fitness landscapes During the struggle for survival, populations occasionally evolve new functions that give them access to untapped ecological opportunities. Theory suggests that coevolution between species can promote the evolution of such innovations by deforming fitness landscapes in ways that open new adaptive pathways. We directly tested this idea by using high throughput gene editing-phenotyping technology (MAGE-Seq) to measure the fitness landscape of a virus, bacteriophage {lambda}, as it coevolved with its host, the bacterium Escherichia coli. Through computer simulations of {lambda}s evolution on the empirical fitness landscape, we showed that {lambda} was more likely to evolve to use a new receptor if it experienced a shift in its fitness landscape caused by coevolution. This result was further validated by additional laboratory experiments. This study provides direct evidence for the role of coevolution in driving evolutionary novelty and provides a quantitative framework for predicting evolution in coevolving ecological communities.
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The categories of this paper are: genomics
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The categories of this paper are: pharmacology
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The categories of this paper are: neuroscience
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The categories of this paper are: epidemiology
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The categories of this paper are: cell
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The categories of this paper are: toxicology
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The categories of this paper are: cancer
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The categories of this paper are: bioengineering
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The categories of this paper are: education
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The categories of this paper are: cognition
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The categories of this paper are: systems
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The categories of this paper are: plant
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The categories of this paper are: biochemistry
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The categories of this paper are: genetics
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The categories of this paper are: behavior
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The categories of this paper are: immunology