Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: The physicist's guide to one of biotechnology's hottest new topics:
  CRISPR-Cas   Clustered regularly interspaced short palindromic repeats (CRISPR) and
CRISPR-associated proteins (Cas) constitute a multi-functional, constantly
evolving immune system in bacteria and archaea cells. A heritable, molecular
memory is generated of phage, plasmids, or other mobile genetic elements that
attempt to attack the cell. This memory is used to recognize and interfere with
subsequent invasions from the same genetic elements. This versatile prokaryotic
tool has also been used to advance applications in biotechnology. Here we
review a large body of CRISPR-Cas research to explore themes of evolution and
selection, population dynamics, horizontal gene transfer, specific and
cross-reactive interactions, cost and regulation, non-immunological CRISPR
functions that boost host cell robustness, as well as applicable mechanisms for
efficient and specific genetic engineering. We offer future directions that can
be addressed by the physics community. Physical understanding of the CRISPR-Cas
system will advance uses in biotechnology, such as developing cell lines and
animal models, cell labeling and information storage, combatting antibiotic
resistance, and human therapeutics.

5
The categories of this paper are: gr-qc
4
The categories of this paper are: cond-mat
14
The categories of this paper are: math-ph
22
The categories of this paper are: chao-dyn
25
The categories of this paper are: patt-sol
29
The categories of this paper are: funct-an
30
The categories of this paper are: q-alg
17
The categories of this paper are: q-fin
21
The categories of this paper are: adap-org
12
The categories of this paper are: nucl-th
34
The categories of this paper are: chem-ph
11
The categories of this paper are: hep-lat
15
The categories of this paper are: nucl-ex
37
The categories of this paper are: supr-con
19
The categories of this paper are: eess
1
The categories of this paper are: cs