Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: A flexible electronic strain sensor for the real-time monitoring of tumor progression Assessing the efficacy of cancer therapeutics in mouse models is a critical step in treatment development. However, low resolution measurement tools and small sample sizes make determining drug efficacy in vivo a difficult and time-intensive task. Here we present a commercially scalable wearable electronic sensor that automates the in vivo testing of cancer therapeutics by continuously monitoring micrometer-scale tumor volume progression or regression in real-time. Histology, caliper measurements, and bioluminescence imaging over a one-week treatment period validated the sensors recordings, but the sensors higher time and length scale resolutions provided the only measurement technique capable of continuously monitoring the immediate hour-scale pharmacodynamic response of a given drug. In mice with two subcutaneously implanted tumor models our sensors recorded significant volume reductions in tumors just 5 hours after small molecule or immunotherapy treatment initiation. We anticipate that real-time tumor regression datasets could help expedite and automate the process of screening cancer therapies in vivo.
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The categories of this paper are: neuroscience
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The categories of this paper are: behavior
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The categories of this paper are: molecular
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The categories of this paper are: cell
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The categories of this paper are: animal
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The categories of this paper are: scientific
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The categories of this paper are: zoology
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The categories of this paper are: biophysics
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The categories of this paper are: education
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The categories of this paper are: microbiology
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The categories of this paper are: genetics
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The categories of this paper are: genomics
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The categories of this paper are: and
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The categories of this paper are: paleontology
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The categories of this paper are: cancer
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The categories of this paper are: epidemiology