Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: A Human-Immune-System (HIS) humanized mouse model for COVID-19 research (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2Rγc KO.NOD) We report the first Human Immune System (HIS)-humanized mouse model ("DRAGA": HLA-A2.HLA-DR4.Rag1KO.IL-2R{gamma}cKO.NOD) for COVID-19 research. This mouse is reconstituted with human cord blood-derived, HLA-matched hematopoietic stem cells. It engrafts human epi/endothelial cells expressing the human ACE2 receptor for SARS-CoV-2 and TMPRSS2 serine protease co-localized on lung epithelia. HIS-DRAGA mice sustained SARS-CoV-2 infection, showing deteriorated clinical condition, replicating virus in the lungs, and human-like lung immunopathology including T-cell infiltrates, microthrombi and pulmonary sequelae. Among T-cell infiltrates, lung-resident (CD103+) CD8+ T cells were sequestered in epithelial (CD326+) lung niches and secreted granzyme B and perforin, indicating cytotoxic potential. Infected mice also developed antibodies against the SARS-CoV-2 viral proteins. Hence, HIS-DRAGA mice showed unique advantages as a surrogate in vivo human model for studying SARS-CoV-2 immunopathology and for testing the safety and efficacy of candidate vaccines and therapeutics.
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The categories of this paper are: bioinformatics
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The categories of this paper are: cell
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The categories of this paper are: animal
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The categories of this paper are: ecology
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The categories of this paper are: biology
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The categories of this paper are: scientific
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The categories of this paper are: evolutionary
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The categories of this paper are: biochemistry
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The categories of this paper are: cancer
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The categories of this paper are: cognition
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The categories of this paper are: microbiology
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The categories of this paper are: behavior
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The categories of this paper are: communication
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The categories of this paper are: synthetic
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The categories of this paper are: genetics
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The categories of this paper are: zoology