Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: The Myogenic Response in Isolated Rat Cerebrovascular Arteries: Smooth
  Muscle Cell Model   Previous models of the cerebrovascular smooth muscle cell have not addressed
the interaction between the electrical, chemical and mechanical components of
cell function during the development of active tension. These models are
primarily electrical, biochemical or mechanical in their orientation, and do
not permit a full exploration of how the smooth muscle responds to electrical
or mechanical forcing. To address this issue, we have developed a new model
that consists of two major components: electrochemical and chemomechanical
subsystems of the cell. Included in the electrochemical model are models of the
electrophysiological behavior of the cell membrane, fluid compartments, Ca2+
release and uptake by the sarcoplasmic reticulum, and cytosolic Ca2+ buffering,
particularly by calmodulin. With this subsystem model, we can study the
mechanics of the production of intracellular Ca2+ transient in response to
membrane voltage clamp pulses. The chemomechanical model includes models of:
(a) the chemical kinetics of myosin phosphorylation, and the formation of
phosphorylated myosin cross-bridges with actin, as well as, attached latch-type
cross-bridges; and (b) a model of force generation and mechanical coupling to
the contractile filaments and their attachments to protein structures and the
skeletal framework of the cell. The two subsystem models are tested
independently and compared with data. Likewise, the complete (combined) cell
model responses to voltage pulse stimulation under isometric and isotonic
conditions are calculated and compared with measured single cell length-force
and force-velocity data obtained from literature. This integrated cell model
provides biophysically-based explanations of electrical, chemical and
mechanical phenomena in cerebrovascular smooth muscle, and has considerable
utility as an adjunct to laboratory research and experimental design.

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The categories of this paper are: nucl-ex
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The categories of this paper are: stat
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The categories of this paper are: supr-con
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The categories of this paper are: econ
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The categories of this paper are: cmp-lg
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The categories of this paper are: patt-sol
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The categories of this paper are: q-fin
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The categories of this paper are: q-alg
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The categories of this paper are: ao-sci
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The categories of this paper are: plasm-ph
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The categories of this paper are: cs
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The categories of this paper are: nucl-th
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The categories of this paper are: comp-gas
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The categories of this paper are: bayes-an
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The categories of this paper are: alg-geom
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The categories of this paper are: mtrl-th