Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: FANCA: In-Silico deleterious mutation analysis for early prediction of
  leukemia   As a novel biomarker from the Fanconi anemia complementation group (FANC)
family, FANCA is antigens to Leukemia cancer. The overexpression of FANCA has
predicted the second most common cancer in the world that is responsible for
cancer-related deaths. Non-synonymous SNPs are an essential group of SNPs that
lead to alterations in encoded polypeptides. Changes in the amino acid
sequences of gene products lead to Leukemia. First, we study individual SNPs in
the coding region of FANCA and computational tools like PROVEAN, PolyPhen2,
MuPro, and PANTHER to compute deleterious mutation scores. The
three-dimensional structural and functional prediction conducted using
I-TASSER. Further, the predicted structure refined using the GlaxyWeb tool. In
the study, the proteomic data has been retrieved from the UniProtKB. The coding
region of the dataset contains 100 non-synonymous single nucleotide
polymorphisms (nsSNPs), and 24 missense SNPs have been determined as
deleterious by all analyses. In this work, six well-known computational tools
were employed to study Leukemia-associated nsSNPs. It is inferred that these
nsSNPs could play their role in the up-regulation of FANCA, which further leads
to provoke leukemia advancement. The current research would benefit researchers
and practitioners in handling cancer-associated diseases related to FANCA. The
proposed study would also help to develop precision medicine in the field of
drug discovery.

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The categories of this paper are: hep-ex
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The categories of this paper are: q-fin
24
The categories of this paper are: dg-ga
4
The categories of this paper are: cond-mat
35
The categories of this paper are: mtrl-th
16
The categories of this paper are: stat
7
The categories of this paper are: hep-th
6
The categories of this paper are: astro-ph
11
The categories of this paper are: hep-lat
5
The categories of this paper are: gr-qc
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The categories of this paper are: econ
19
The categories of this paper are: eess
31
The categories of this paper are: ao-sci
25
The categories of this paper are: patt-sol
36
The categories of this paper are: cmp-lg
30
The categories of this paper are: q-alg