Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Evidence for the presence and diagnostic utility of SPM in human peripheral blood We thank ODonnell et al, for their comments on our contribution and are grateful to be afforded this opportunity to formally respond to their critique24.

We are surprised by the authors assertion relating to the biological relevance of SPM because a simple literature search for related terms such as  resolvin in PubMed yields an abundance (>1,420 publications) of evidence supporting the potent biological activities and the diagnostic potential of some of these mediators. Several co-authors of the ODonnells et al manuscript, have published on the resolvins and SPMs, including some publications within recent weeks. Importantly, ODonnell et al, misreport as well as mis-apply criteria for peak identification reported in the Gomez et al, publication which lead to the flawed analysis they performed.

In this response therefore, we provide a step-by-step clarification of the methodologies used in Gomez et al, and a side-by-side comparison of the underlying data to clarify any confusion. We also demonstrate that using the orthogonal criteria discussed by ODonnell et al, we obtain essentially identical results thus providing additional validation of our techniques and support the conclusions.
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The categories of this paper are: cell
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The categories of this paper are: genetics
20
The categories of this paper are: pharmacology
31
The categories of this paper are: paleontology
25
The categories of this paper are: bioengineering
30
The categories of this paper are: scientific
17
The categories of this paper are: molecular
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The categories of this paper are: synthetic
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The categories of this paper are: plant
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The categories of this paper are: epidemiology
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The categories of this paper are: and
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The categories of this paper are: cancer
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The categories of this paper are: genomics
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The categories of this paper are: bioinformatics
29
The categories of this paper are: education
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The categories of this paper are: behavior