Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii Coenzyme A (CoA) is an essential molecule acting in metabolism, post-translational modification, and regulation of gene expression. While all organisms synthesize CoA, many, including humans, are unable to produce its precursor, pantothenate. Intriguingly, like most plants, fungi and bacteria, parasites of the coccidian subgroup of Apicomplexa, including the human and animal pathogen Toxoplasma gondii, possess all the enzymes required for de novo synthesis of pantothenate. Here, the importance of CoA and pantothenate biosynthesis for the acute and chronic stages of T. gondii infection was dissected through genetic, biochemical and metabolomic approaches, revealing that CoA synthesis is essential for T. gondii tachyzoites, due to the parasites inability to salvage CoA or intermediates of the pathway. In contrast, de novo pantothenate synthesis was only partially active in T. gondii tachyzoites, making the parasite reliant on Pan uptake. However, Pan synthesis proved to be crucial for the establishment of chronic infection, offering a promising target for intervention against the persistent stage of T. gondii.
1
The categories of this paper are: bioinformatics
21
The categories of this paper are: toxicology
12
The categories of this paper are: behavior
20
The categories of this paper are: pharmacology
29
The categories of this paper are: education
7
The categories of this paper are: ecology
25
The categories of this paper are: bioengineering
32
The categories of this paper are: zoology
0
The categories of this paper are: genetics
5
The categories of this paper are: cell
17
The categories of this paper are: molecular
28
The categories of this paper are: communication
31
The categories of this paper are: paleontology
2
The categories of this paper are: biology
9
The categories of this paper are: synthetic
27
The categories of this paper are: pathology