Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing The Oxford Nanopore (ONT) platform provides portable and rapid genome sequencing, and its ability to natively profile DNA methylation without complex sample processing is attractive for clinical sequencing. We recently demonstrated ONT shallow whole-genome sequencing to detect copy number alterations (CNA) from the circulating tumor DNA (ctDNA) of cancer patients. Here, we show that cell-type and cancer-specific methylation changes can also be detected, as well as cancer-associated fragmentation signatures. This feasibility study suggests that ONT shallow WGS could be a powerful tool for liquid biopsy, especially real-time medical applications.
21
The categories of this paper are: toxicology
18
The categories of this paper are: systems
0
The categories of this paper are: genetics
10
The categories of this paper are: and
13
The categories of this paper are: animal
14
The categories of this paper are: biophysics
26
The categories of this paper are: biochemistry
22
The categories of this paper are: physiology
11
The categories of this paper are: cognition
7
The categories of this paper are: ecology
3
The categories of this paper are: evolutionary
12
The categories of this paper are: behavior
6
The categories of this paper are: plant
15
The categories of this paper are: developmental
28
The categories of this paper are: communication
32
The categories of this paper are: zoology