Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Alpha7 nicotinic acetylcholine receptor signaling modulates ovine fetal
  brain astrocytes transcriptome in response to endotoxin   Neuroinflammation in utero may result in lifelong neurological disabilities.
Astrocytes play a pivotal role, but the mechanisms are poorly understood. No
early postnatal treatment strategies exist to enhance neuroprotective potential
of astrocytes. We hypothesized that agonism on alpha7 nicotinic acetylcholine
receptor (alpha7nAChR) in fetal astrocytes will augment their neuroprotective
transcriptome profile, while the antagonistic stimulation of alpha7nAChR will
achieve the opposite. Using an in vivo - in vitro model of developmental
programming of neuroinflammation induced by lipopolysaccharide (LPS), we
validated this hypothesis in primary fetal sheep astrocytes cultures re-exposed
to LPS in presence of a selective alpha7nAChR agonist or antagonist. Our RNAseq
findings show that a pro-inflammatory astrocyte transcriptome phenotype
acquired in vitro by LPS stimulation is reversed with alpha7nAChR agonistic
stimulation. Conversely, antagonistic alpha7nAChR stimulation potentiates the
pro-inflammatory astrocytic transcriptome phenotype. Furthermore, we conduct a
secondary transcriptome analysis against the identical alpha7nAChR experiments
in fetal sheep primary microglia cultures and discuss the implications for
neurodevelopment.

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The categories of this paper are: cond-mat
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The categories of this paper are: hep-lat
31
The categories of this paper are: ao-sci
17
The categories of this paper are: q-fin
3
The categories of this paper are: physics
5
The categories of this paper are: gr-qc
30
The categories of this paper are: q-alg
14
The categories of this paper are: math-ph
24
The categories of this paper are: dg-ga
26
The categories of this paper are: bayes-an
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The categories of this paper are: nlin
35
The categories of this paper are: mtrl-th
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The categories of this paper are: acc-phys
28
The categories of this paper are: alg-geom
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The categories of this paper are: math
15
The categories of this paper are: nucl-ex