Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Distinct in vivo dynamics of excitatory synapses onto cortical pyramidal neurons and inhibitory interneurons Cortical function relies on the balanced activation of excitatory and inhibitory neurons. However, little is known about the organization and dynamics of shaft excitatory synapses onto cortical inhibitory interneurons, which cannot be easily identified morphologically. Here, we fluorescently visualize the excitatory postsynaptic marker PSD-95 at endogenous levels as a proxy for excitatory synapses onto layer 2/3 pyramidal neurons and parvalbumin-positive (PV+) inhibitory interneurons in the mouse barrel cortex. Longitudinal in vivo imaging reveals that, while synaptic weights in both neuronal types are log-normally distributed, synapses onto PV+ neurons are less heterogeneous and more stable. Markov-model analyses suggest that the synaptic weight distribution is set intrinsically by ongoing cell type-specific dynamics, and substantial changes are due to accumulated gradual changes. Synaptic weight dynamics are multiplicative, i.e., changes scale with weights, though PV+ synapses also exhibit an additive component. These results reveal that cell type-specific processes govern cortical synaptic strengths and dynamics.
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The categories of this paper are: epidemiology
26
The categories of this paper are: biochemistry
5
The categories of this paper are: cell
22
The categories of this paper are: physiology
27
The categories of this paper are: pathology
2
The categories of this paper are: biology
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The categories of this paper are: scientific
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The categories of this paper are: education
32
The categories of this paper are: zoology
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The categories of this paper are: communication
15
The categories of this paper are: developmental
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The categories of this paper are: toxicology
6
The categories of this paper are: plant
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The categories of this paper are: molecular
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The categories of this paper are: biophysics
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The categories of this paper are: paleontology