Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: LKB1 Is Physiologically Required for Sleep from Drosophila to the Mouse LKB1 is known as a master kinase for 14 kinases related to the adenosine monophosphate (AMP)-activated protein kinase (AMPK). Two of them (SIK3 and AMPK) have previously been implicated in sleep regulation. We generated loss-of-function (LOF) mutants for Lkb1 in both Drosophila and mice. Sleep was reduced in Lkb1-mutant flies and in flies with neuronal deletion of Lkb1. Sleep was reduced in mice after virally mediated reduction of Lkb1 in the brain. Electroencephalography (EEG) analysis showed that non-rapid eye movement (NREM) sleep and sleep need were both reduced in Lkb1-mutant mice. These results indicate that LKB1 plays a physiological role in sleep regulation conserved from flies to mice.
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The categories of this paper are: cancer
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The categories of this paper are: plant
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The categories of this paper are: bioinformatics
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The categories of this paper are: epidemiology
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The categories of this paper are: microbiology
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The categories of this paper are: synthetic
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The categories of this paper are: communication
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The categories of this paper are: zoology
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The categories of this paper are: paleontology
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The categories of this paper are: ecology
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The categories of this paper are: bioengineering
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The categories of this paper are: genomics
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The categories of this paper are: toxicology
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The categories of this paper are: biology
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The categories of this paper are: genetics
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The categories of this paper are: and