Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: A combination of mRNA features influence the efficiency of leaderless mRNA translation initiation Bacterial translation is thought to initiate by base-pairing of the 16S rRNA and the Shine-Dalgarno sequence in the mRNAs 5UTR. However, transcriptomics has revealed that leaderless mRNAs, which completely lack any 5UTR, are broadly distributed across bacteria and can initiate translation in the absence of the Shine-Dalgarno sequence. To investigate the mechanism of leaderless mRNA translation initiation, synthetic in vivo translation reporters were designed that systematically tested the effects of start codon accessibility, leader length, and start codon identity on leaderless mRNA translation initiation. Using this data, a simple computational model was built based on the combinatorial relationship of these mRNA features which can accurately classify leaderless mRNAs and predict the translation initiation efficiency of leaderless mRNAs. Thus, start codon accessibility, leader length, and start codon identity combine to define leaderless mRNA translation initiation in bacteria.
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The categories of this paper are: immunology
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The categories of this paper are: epidemiology
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The categories of this paper are: ecology
29
The categories of this paper are: education
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The categories of this paper are: biophysics
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The categories of this paper are: cancer
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The categories of this paper are: behavior
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The categories of this paper are: pharmacology
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The categories of this paper are: microbiology
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The categories of this paper are: genomics
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The categories of this paper are: molecular
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The categories of this paper are: biochemistry
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The categories of this paper are: and
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The categories of this paper are: genetics
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The categories of this paper are: neuroscience
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The categories of this paper are: physiology