Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Regulation by small RNAs via coupled degradation: mean-field and
  variational approaches   Regulatory genes called small RNAs (sRNAs) are known to play critical roles
in cellular responses to changing environments. For several sRNAs, regulation
is effected by coupled stoichiometric degradation with messenger RNAs (mRNAs).
The nonlinearity inherent in this regulatory scheme indicates that exact
analytical solutions for the corresponding stochastic models are intractable.
Here, we present a variational approach to analyze a well-studied stochastic
model for regulation by sRNAs via coupled degradation. The proposed approach is
efficient and provides accurate estimates of mean mRNA levels as well as higher
order terms. Results from the variational ansatz are in excellent agreement
with data from stochastic simulations for a wide range of parameters, including
regions of parameter space where mean-field approaches break down. The proposed
approach can be applied to quantitatively model stochastic gene expression in
complex regulatory networks.

7
The categories of this paper are: hep-th
16
The categories of this paper are: stat
19
The categories of this paper are: eess
17
The categories of this paper are: q-fin
31
The categories of this paper are: ao-sci
37
The categories of this paper are: supr-con
36
The categories of this paper are: cmp-lg
4
The categories of this paper are: cond-mat
21
The categories of this paper are: adap-org
32
The categories of this paper are: atom-ph
1
The categories of this paper are: cs
26
The categories of this paper are: bayes-an
25
The categories of this paper are: patt-sol
15
The categories of this paper are: nucl-ex
23
The categories of this paper are: solv-int
18
The categories of this paper are: econ