Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Interferons Reshape the 3D Conformation and Accessibility of Macrophage Chromatin Engagement of macrophages in innate immune responses is directed and enhanced by type I and type II interferons. An essential component of IFN activity is the use of JAK-STAT signal transduction for the transcriptional control of interferon-stimulated genes (ISG). Here, we study the immediate early nuclear response to type I IFN and IFN-{gamma} in murine macrophages. Despite their distinct immunological activities, both IFN types triggered highly overlapping epigenomic and transcriptional changes. These changes included a rapid rearrangement of the 3D chromatin organization and an increase of DNA accessibility at ISG loci. ISGF3, the major transcriptional regulator of ISG, controlled homeostatic as well as induced-state DNA accessibility at a subset of ISG. Increases in DNA accessibility correlated with the appearance of activating histone marks at surrounding nucleosomes. Collectively our data emphasize changes in the three-dimensional nuclear space and epigenome as an important facet of transcriptional control by the IFN-induced JAK-STAT pathway.
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The categories of this paper are: cognition
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The categories of this paper are: genomics
30
The categories of this paper are: scientific
7
The categories of this paper are: ecology
5
The categories of this paper are: cell
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The categories of this paper are: pharmacology
28
The categories of this paper are: communication
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The categories of this paper are: animal
24
The categories of this paper are: cancer
12
The categories of this paper are: behavior
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The categories of this paper are: epidemiology
32
The categories of this paper are: zoology
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The categories of this paper are: and
22
The categories of this paper are: physiology
29
The categories of this paper are: education
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The categories of this paper are: synthetic