Instruct: Identify the main category of Medrxiv papers based on the titles and abstracts
Query: SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and death in some patients. Although severe COVID-19 disease is linked to exuberant inflammation, how SARS-CoV-2 triggers inflammation is not understood. Monocytes are sentinel blood cells that sense invasive infection to form inflammasomes that activate caspase-1 and gasdermin D (GSDMD) pores, leading to inflammatory death (pyroptosis) and processing and release of IL-1 family cytokines, potent inflammatory mediators. Here we show that ~10% of blood monocytes in COVID-19 patients are dying and infected with SARS-CoV-2. Monocyte infection, which depends on antiviral antibodies, activates NLRP3 and AIM2 inflammasomes, caspase-1 and GSDMD cleavage and relocalization. Signs of pyroptosis (IL-1 family cytokines, LDH) in the plasma correlate with development of severe disease. Moreover, expression quantitative trait loci (eQTLs) linked to higher GSDMD expression increase the risk of severe COVID-19 disease (odds ratio, 1.3, p<0.005). These findings taken together suggest that antibody-mediated SARS-CoV-2 infection of monocytes triggers inflammation that contributes to severe COVID-19 disease pathogenesis.

One sentence summaryAntibody-mediated SARS-CoV-2 infection of monocytes activates inflammation and cytokine release.
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The categories of this paper are: medical
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The categories of this paper are: geriatric
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The categories of this paper are: gynecology
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The categories of this paper are: allergy
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The categories of this paper are: psychology
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The categories of this paper are: palliative
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The categories of this paper are: and
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The categories of this paper are: quality
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The categories of this paper are: radiology
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The categories of this paper are: imaging
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The categories of this paper are: critical
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The categories of this paper are: genomic
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The categories of this paper are: oral
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The categories of this paper are: medicine
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The categories of this paper are: surgery
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The categories of this paper are: urology