Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Novel insights in the pathophysiology of α-synuclein dysregulation on D2 receptor activity contributing to the vulnerability of dopamine neurons Pathophysiological damages and loss of function of dopamine neurons precedes their demise and contributes to the early phases of Parkinsons disease. The presence of aberrant intercellular pathological inclusions of the protein -synuclein within ventral midbrain dopaminergic neurons is one of the cardinal features of Parkinsons disease. We employed multiple complementary approaches in molecular biology, electrophysiology, and live-cell imaging to investigate how excessive -synuclein levels alters multiple characteristics of dopaminergic neuronal dynamics and dopamine transmission prior to neuronal demise. These studies demonstrate that -synuclein dysregulation of D2 receptor autoinhibition contributes to the vulnerability of dopaminergic neurons, and that modulation thereof can ameliorate the resulting pathophysiology. These novel findings provide mechanistic insights in the insidious loss of dopaminergic function and neurons that characterize Parkinsons disease progression with significant therapeutic implications.
24
The categories of this paper are: cancer
0
The categories of this paper are: genetics
32
The categories of this paper are: zoology
17
The categories of this paper are: molecular
9
The categories of this paper are: synthetic
5
The categories of this paper are: cell
30
The categories of this paper are: scientific
7
The categories of this paper are: ecology
8
The categories of this paper are: genomics
21
The categories of this paper are: toxicology
22
The categories of this paper are: physiology
6
The categories of this paper are: plant
23
The categories of this paper are: immunology
11
The categories of this paper are: cognition
28
The categories of this paper are: communication
12
The categories of this paper are: behavior