Instruct: Identify the main category of Biorxiv papers based on the titles and abstracts
Query: Dissociable developmental trajectories of Orbitofrontal subregion grey matter volume. Adolescence is a period of development which is characterised by distinct differences in decision-making strategies relative to adults. While it is broadly established that there are relative differences in the structural maturation of the prefrontal cortex (PFC) and subcortical reward nuclei, such as the amygdala and ventral striatum, heterogeneity within the PFC is often neglected. In particular very little is known about the fine-scale gray matter (GM) development of the Orbitofrontal Cortex (OFC), itself critical to a number of learning and decision-making mechanisms which show delayed development trajectories. Here we applied voxel-based morphometry to examine subregional differences in OFC grey matter in high-quality structural MRI scans of 125 subjects aged 11-35yrs from the Human Connectome Project. First, we examined fine-scale GM maturation in 5 anatomically dissociable OFC subregions and identified the best-fitting polynomial model. Next, we directly compared developmental trajectories across 3 functionally dissociable subregions, revealing a complex topological developmental profile from medial to lateral subregions. Collectively, the two complementary analyses suggest that while unequivocally the phylogenetically younger lateral OFCs showed the greatest shift in GM volume across adolescence, with maturation continuing well into young adulthood, the differences between the medial and central OFC subregions suggested a more complex pattern of maturation than a simple graded medial to lateral topological development. We argue that knowledge of these fine-scale anatomical differences in maturation could explain precise mechanistic differences in goal-directed behaviours.
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The categories of this paper are: microbiology
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The categories of this paper are: systems
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The categories of this paper are: developmental
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The categories of this paper are: pharmacology
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The categories of this paper are: physiology
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The categories of this paper are: molecular
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The categories of this paper are: genomics
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The categories of this paper are: and
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The categories of this paper are: cognition
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The categories of this paper are: biophysics
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The categories of this paper are: communication
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The categories of this paper are: bioengineering
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The categories of this paper are: pathology
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The categories of this paper are: synthetic
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The categories of this paper are: biology
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The categories of this paper are: education