Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: The Range of Cooperativity Modulates Actin Binding Protein Cluster Size,
  Density and Dynamics   The actin cytoskeleton is composed of multiple networks which are specialized
for several processes such as cell motility or cell division. Each of these
networks are composed of organized actin microfilaments which are decorated
with specific sets of actin binding proteins (ABPs). The molecular mechanisms
guiding ABPs to specific actin networks are still poorly understood, but
cooperativity, the mechanism by which the binding of an ABP is positively
influenced by proximal bound ABPs, plays a crucial role in generating locally
dense stretches of ABPs. Cooperative binding is characterized by its amplitude,
but also by the range at which its effects are propagated along an actin
filament through long-range allosteric interactions. The range of these
allosteric effects is still debated, but is likely to be significant at the
lengthscale of actin filaments in cells. Here, we investigated how
cooperativity influences the clustering of ABPs, using a stochastic
computational model of binding of ABPs to actin filaments. The model reproduces
the formation of ABP clusters observed experimentally at the single filament
scale, and provides a theoretical estimation of the range of cooperativity for
proteins such as ADF/cofilin. We found that both the amplitude and the spatial
range of cooperativity dramatically impact the properties of clustering.
However, the parameters of cooperativity modulate differently the rate of
assembly, size and dynamics of the ABP clusters, suggesting that cooperativity
is an efficient mechanism to regulate precisely the recruitment of ABPs in
cells. This work provides a more general framework for future understanding of
how actin networks acquire distinct and specific protein compositions from a
common cytoplasm.

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The categories of this paper are: astro-ph
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The categories of this paper are: econ
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The categories of this paper are: gr-qc
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The categories of this paper are: dg-ga
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The categories of this paper are: quant-ph
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The categories of this paper are: bayes-an
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The categories of this paper are: q-fin
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The categories of this paper are: plasm-ph
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The categories of this paper are: cmp-lg
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The categories of this paper are: eess
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The categories of this paper are: stat
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The categories of this paper are: q-alg
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The categories of this paper are: hep-lat
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The categories of this paper are: nucl-ex
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The categories of this paper are: mtrl-th
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The categories of this paper are: hep-ex