Instruct: Identify the main and secondary category of Arxiv papers based on the titles and abstracts
Query: Cortical microtubule nucleation can organise the cytoskeleton of
  $Drosophila$ oocytes to define the anteroposterior axis   Many cells contain non-centrosomal arrays of microtubules (MT), but the
assembly, organisation and function of these arrays are poorly understood. We
present the first theoretical model for the non-centrosomal MT cytoskeleton in
$Drosophila$ oocytes, in which $bicoid$ and $oskar$ mRNAs become localised to
establish the anterior-posterior body axis. Constrained by experimental
measurements, the model shows that a simple gradient of cortical MT nucleation
is sufficient to reproduce the observed MT distribution, cytoplasmic flow
patterns and localisation of $oskar$ and naive $bicoid$ mRNAs. Our simulations
exclude a major role for cytoplasmic flows in localisation and reveal an
organisation of the MT cytoskeleton that is more ordered than previously
thought. Furthermore, modulating cortical MT nucleation induces a bifurcation
in cytoskeletal organisation that accounts for the phenotypes of polarity
mutants. Thus, our three-dimensional model explains many features of the MT
network and highlights the importance of differential cortical MT nucleation
for axis formation.

9
The categories of this paper are: nlin
37
The categories of this paper are: supr-con
34
The categories of this paper are: chem-ph
28
The categories of this paper are: alg-geom
31
The categories of this paper are: ao-sci
13
The categories of this paper are: quant-ph
22
The categories of this paper are: chao-dyn
21
The categories of this paper are: adap-org
7
The categories of this paper are: hep-th
2
The categories of this paper are: math
36
The categories of this paper are: cmp-lg
35
The categories of this paper are: mtrl-th
29
The categories of this paper are: funct-an
15
The categories of this paper are: nucl-ex
19
The categories of this paper are: eess
8
The categories of this paper are: hep-ex