Statistically, what is the best opening? Statistically, what opening has white won with the most?

Such as, 1.e4 e5 2?

What is the move that white makes that has won the most games?
Here is a tongue-in-cheek answer. The 4 move checkmate (1. e4 e5 2.Qf3 Nc6 3.Bc4 Bc5?? 4.Qxf7#) is an opening where White has won 100% of the time.

The reason why I post this answer is to highlight a few flaws in the question you asked:


Maybe if you find an opening with a high win ratio, you will build your reportaire around it? This is flawed logic as Black can sidestep your preparation, which may lead you into a bad line. Instead, play the openings that feel right for your playing style
What is an opening? Ultimately the opening are just the first few moves in the game. Crucially for a statistical question, you didn't say how many moves you are looking at. The first? The first 10? Assuming best play with Black? In most chess games, there are many moves other than those in the opening stage that determine the outcome of the game. I'd suggest you concentrate more on the middle and endgame than the opening