Is "the ends justify the means" compatible with Christianity? This cliche is usually quoted in the context of "the ends don't justify the means", but in practice most folks seem to live as if the ends did justify the means even if the means involved sin. However sometimes people cannot see clearly what is sin and what isn't. An example might be with-holding information from a loved one so as not to upset them.

While on clear situation of sin they might come down one way, given a predicament where the right choice isn't clear to a person, they often turn this cliche the other way around and tell themselves that the ends do justify the means.

Is there any Biblical content that speaks to this cliche one way or another. Is there a good "retort cliche" that one could use as a reminder of the proper way to make a moral or ethical decision in light of Christian teachings?
The idea that "the ends justify the means" admits that there is something inherently wrong with "the means".  Indeed, it admits that "the means" are actually unjustified by themselves.  The claim, then, is that although "the means" are unjustifiable in themselves, that a particular outcome that is achieved by them results in the justification of the unjustified.  

Christianity certainly does not have any basis for this idea, and it doesn't need any.  I know of a particular religion that believes it's alright for its followers to lie in a conversation with someone of another religion if lying helps them win the argument.  Christianity, however, does not need to do this, because Christianity believes that truth is on its side.  That's a key point, because Truth invites questioning, whereas lies and falsehoods do not.

God calls us to do what is righteous and then trust Him for the results.