First layer - not even infill I'm using Repetier and Slic3r and it is printing a gap between the perimeter and infill on the first layer. 
Also, the infill is lifting (as in photo).
Any advise?
You're not sticking to your bed. Adjust your bed height. You are too far.
Otherwise you are going too fast and or too hot.

Calibrate the bed. Reduce speed. Then adjust temps. 

Also could be material contamination

See this link for a visual troubleshooting.

http://reprap.org/wiki/Print_Troubleshooting_Pictorial_Guide

http://support.3dverkstan.se/article/23-a-visual-ultimaker-troubleshooting-guide

In addition use some gluestick. That will often solve these issues. Last but not least add a raft if it continues. Or just ignore it. My bet is temp is too hot. I also like to smash my first layer, but not everyone likes that technique as it causes elephant footing.