@article{klupinska_[effect_2009,
 abstract = {The oxidative damage of DNA expresses severe cell lesion. The excess of oxygen free radicals is one of the causes of this type of disorders. Such a situation could occur in the course of H. pylori infection. Melatonin is a natural and very active antioxidant compound.
AIM OF STUDY: To establish weather an administration of melatonin decreases oxidative DNA damage in gastric mucosa cells.
MATERIAL AND METHODS: The study comprised 80 subjects, divided into two groups: group I (n=30)--patients with functional dyspepsia, H. pylori positive (+), with Epigastric Pain Syndrome, with H. pylori infection; group II (n=30)--patients H. pylori negative (-) with the same form of functional dyspepsia. The control group (0) comprised 20 subjects, aged 21-60 years.
RESULTS: In healthy subjects, non-infected with H. pylori the level of oxidative DNA damage in gastric mucosa cells was 6.95 +/- 2.98. In both study groups the percentage of oxidative DNA damage was respectively: 12.12 +/- 5.48\% and 13.62 +/- 4.58\% (p {\textless} 0.001). The differences in the results obtained in both study groups, that is H. pylori (+) and H. pylori (-) were similar (p {\textgreater} 0.05). In group of patients with functional dyspepsia and H. pylori infection the level of oxidative DNA damage in gastrocytes was 12.12 +/- 5.48\%, and after 3 months administration of melatonin it decreased to the value 10.55 +/- 0.63\% (p {\textless} 0.001). In patients with functional dyspepsia, without H. pylori infection the decrease of the level of oxidative DNA damages after melatonin administration was statistically significant and it was respectively: 13.62 +/- 4.58\% (p {\textless} 0.001).
CONCLUSIONS: In functional dyspepsia, especially with coexisting H. pylori infection the oxidative DNA damage in gastric mucosa cells is observed. The melatonin administration changes the above mentioned oxidative DNA damage significantly.},
 author = {<NAME> <NAME>},
 issn = {1426-9686},
 journal = {Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego},
 keywords = {Adult, Antioxidants, DNA Damage, Dyspepsia, Female, Gastric Mucosa, Helicobacter Infections, Helicobacter pylori, Humans, Male, Melatonin, Middle Aged, Oxidation-Reduction},
 language = {pol},
 month = {may},
 number = {155},
 pages = {366--369},
 pmid = {19606675},
 title = {[{The} effect of melatonin on oxidative {DNA} damage in gastric mucosa cells of patients with functional dyspepsia]},
 volume = {26},
 year = {2009}
}

