Proteins
What are proteins made of?
Biochemistry
InterPro GFP-cDNA Endoplasmic-reticulum-associated protein degradation Mallory body Telomere-binding protein
InterPro-Data_contained_in_InterPro GFP-cDNA-What_kinds_of_experiments_are_made? Endoplasmic-reticulum-associated_protein_degradation-Questions Mallory_body-Appearance Telomere-binding_protein-Abstract
InterPro contains three main entities: proteins, signatures (also referred to as "methods" or "models") and entries. The proteins in UniProtKB are also the central protein entities in InterPro. Information regarding which signatures significantly match these proteins are calculated as the sequences are released by UniProtKB and these results are made available to the public (see below). The matches of signatures to proteins are what determine how signatures are integrated together into InterPro entries: comparative overlap of matched protein sets and the location of the signatures' matches on the sequences are used as indicators of relatedness. Only signatures deemed to be of sufficient quality are integrated into InterPro. InterPro also includes data for splice variants and the proteins contained in the UniParc and UniMES databases. 
The cDNAs of novel identified Open Reading Frames(ORF) are tagged with Green Fluorescent Protein (GFP) and expressed in eukaryotic cells. Subsequently, the subcellular localisation of the fusion proteins is recorded by fluorescence microscopy. 
The big questions for ERAD are: How are misfolded proteins more specifically recognized? What is the channel for the retrotranslocation of luminal ER proteins? Which E3 ligase finally tags the proteins for the proteasomal degradation?  
Mallory bodies are highly eosinophilic and thus appear pink on H&E stain. The bodies themselves are made up of intermediate keratin filament proteins that have been ubiquinated, or bound by other proteins such as heat shock proteins, or p62. 
Telomere-binding proteins are proteins that mediate telomere function by binding to them. There are two types of telomere-binding proteins: single-strand DNA telomere binding proteins and double-strand DNA telomere binding proteins. 