Effect on different types of cancer
Do all cancers respond in the same way to chemo?
Radiation therapy
Cancer staging Follicular atresia Tioguanine Blüdhaven Skin Tight (novel)
Cancer_staging-Overall_stage_grouping Follicular_atresia-Related_Diseases Tioguanine-Interactions Blüdhaven-Destruction_of_the_city Skin_Tight_(novel)-Plot_summary
Overall Stage Grouping is also referred to as Roman Numeral Staging. This system uses numerals I, II, III, and IV (plus the 0) to describe the progression of cancer. Stage 0: carcinoma in situ. Stage I: cancers are localized to one part of the body. Stage I cancer can be surgically removed if small enough. Stage II: cancers are locally advanced. Stage II cancer can be treated by chemo, radiation, or surgery. Stage III: cancers are also locally advanced. Whether a cancer is designated as Stage II or Stage III can depend on the specific type of cancer; for example, in Hodgkin's Disease, Stage II indicates affected lymph nodes on only one side of the diaphragm, whereas Stage III indicates affected lymph nodes above and below the diaphragm. The specific criteria for Stages II and III therefore differ according to diagnosis. Stage III can be treated by chemo, radiation, or surgery. Stage IV: cancers have often metastasized, or spread to other organs or throughout the body. Stage IV cancer can be treated by chemo, radiation, or surgery. Within the TNM system, a cancer may also be designated as recurrent, meaning that it has appeared again after being in remission or after all visible tumor has been eliminated. Recurrence can either be local, meaning that it appears in the same location as the original, or distant, meaning that it appears in a different part of the body. 
Undergoing follicular atresia is necessary in order for women to maintain a healthy reproductive system. The inability to regulate granulosa cell apoptosis and undergo follicular atresia has been linked to the development of some hormone-related cancers and chemo-resistance. 
Cancers that do not respond to treatment with mercaptopurine do not respond to thioguanine. On the other hand, some cases of IBD that are resistant to mercaptopurine (or its pro-drug azathioprine) may be responsive to thioguanine. 
In "Infinite Crisis" #4, the Secret Society of Super Villains drops Chemo, a gigantic, semi-intelligent pile of chemicals, on the city, causing a devastating explosion and toxic chemical fallout. The city is destroyed. Nightwing, Batgirl and Robin survive, since all were out of the city at the time of the attack, but the fates of other Blüdhaven-based heroes such as Tarantula are unknown. In "Adventures of Superman" #648, official sources set the resulting death toll from Chemo's assault on Blüdhaven at 100,068. Superman and other superheroes such as the Teen Titans enter Blüdhaven to save people from the chemical fallout at the same time that Chemo tries to re-integrate. Superman fights the monster, surmising correctly that Chemo would regenerate more quickly if he were in battle. As Chemo regenerates, he draws the toxins out of the city, removing harmful fall-out and chemical waste. At the culmination of his battle with the regenerating Chemo, Superman hurls the giant into outer space. 
Dr. Rudy Graveline, M.D., the director of the prestigious "Whispering Palms" Surgery Center in Bal Harbour, Florida, is in fact a complete fraud. Apart from the fact that he has never been trained or certified in cosmetic surgery, he is a dangerously clumsy and inept surgeon. He has built his reputation through social connections and by taking credit for the work of his more-competent associates. On the rare occasions when Graveline himself performs surgery, the results are inevitably disastrous. He has weathered numerous malpractice complaints and investigations by the state, through bribery and intimidation. However, there is at least one mistake in Rudy's past that no amount of money or prestige could fix, were it ever to come to light: the accidental killing of a college coed named Victoria Barletta, during a botched nose job. So, when Rudy's former surgical nurse, Maggie Gonzalez, tells Rudy that Mick Stranahan, a retired investigator for the Florida State Attorney's office, is looking into Victoria's disappearance again, Rudy decides to have Stranahan killed. In reality, Maggie is the whistleblower. After promising to repeat the true story on live television, for the sensationalist talk show "In Your Face! ", Maggie has pointed to Stranahan to misdirect Rudy. Stranahan is eating breakfast on his house in Stiltsville, in Biscayne Bay, when a hit man from the mob appears at his front door with a gun. Mick ambushes the man, impaling him through the chest with the sword of a stuffed marlin head, then pushes the body out to sea and decides to find out who wants him dead. He meets the obnoxious host of "In Your Face! ", Reynaldo Flemm, and his producer, Christina Marks, who have come to Miami looking for Maggie after she left New York City without warning. Mick has no time for Reynaldo, but finds himself attracted to Christina (and vice-versa). After the mob hitman's failure, Graveline has tried going with "local talent": a disfigured felon nicknamed "Chemo" who agrees to kill Stranahan in exchange for a discount on his dermabrasion treatments. Chemo locates Stranahan the same way that Christina did: through his vengeful ex-wife, Chloe. When Chemo says he's out to "get" Stranahan, she shows him the way to the stilt house, and eagerly comes along to watch. But when she realizes that Chemo means to kill Stranahan, not just scare him, she objects, since she is still receiving alimony. They begin to argue, and she makes the mistake of insulting his face, to which he responds by drowning her in the Bay. Fortunately for Mick, Chloe's directions were wrong, and Chemo burns down an abandoned stilt house instead of Mick's. The next day, homicide detective Al Garcia and Marine Patrol Officer Luis Cordova visit Mick on his stilt house, and inform him that Chloe's body has been found, and he's the prime suspect in her murder. When Stranahan tells them that someone is trying to kill him, they advise him to lie low. Instead of doing so, Mick visits Dr. Graveline outside his clinic, advises him in the strongest terms to abandon his plans to murder Mick, and emphasizes his point by blowing up the doctor's Jaguar. Mick returns to his stilt house, where Christina visits him. She says that she interviewed Mick's old partner, Timmy Gavigan, at the hospital. Before Timmy died, he told her that he'd remembered a detail from the Barletta case: Graveline's brother, George, is a tree trimmer by profession. She isn't sure what that means, but Stranahan is: most trimmers use a wood chipper, an ideal device for disposing of a body in a hurry. Then Chemo appears on the house with a submachine gun, having been told by Graveline that Mick is still alive. In the ensuing shootout, Mick is wounded in the shoulder, and Chemo dives off the house to avoid a shotgun blast. Swimming around the ocean, his hand is bitten off by a strike from a Great Barracuda. Making his way back to Graveline, he opts to attach a portable weed whacker to the stump of his arm instead of a conventional prosthesis. Graveline gives Chemo another job: to go to New York City and eliminate Maggie Gonzalez. But when Chemo finds her in New York, she mentions being a nurse by training, and tells him the truth about Rudy's incompetence. Mortified that he has entrusted his face to such a dangerous hack, Chemo decides to form a partnership with Maggie, to blackmail Rudy with the knowledge about Victoria Barletta's death. Maggie has created a videotaped confession for security, but Stranahan and Christina have gotten hold of a copy. Returning to Miami, Stranahan delivers the video to Al Garcia, before surviving another murder attempt: this time, a pair of corrupt Miami detectives (former cronies of a corrupt judge that Stranahan killed in self-defense), are hired by one of Rudy's buddies, a corrupt county commissioner, to kill Stranahan. Yet again, Stranahan outfoxes them and lures them into a fatal booby trap. Stranahan also turns up the heat on Graveline by recruiting his brother-in-law, a shyster personal injury lawyer named Kipper Garth, to sue Graveline for malpractice, yet again. He then confronts George Graveline, the tree trimmer, who tries to kill Stranahan rather than talk, and is shot dead by Al Garcia. Chemo and Maggie kidnap Christina, holding her hostage in exchange for Mick's copy of the videotape. Meanwhile, Reynaldo Flemm, jealous of Christina's growing attraction to Mick, comes up with his own plan to break the Barletta case: he schedules a nose job and abdominoplasty with Rudy, planning to conduct an ambush interview once the nose job is done. His "brilliant" plan quickly goes awry when Rudy announces that he plans to do the abdominoplasty first, and puts Reynaldo under general anesthesia. When Reynaldo's cameraman bursts into the operating room to start the interview, Rudy panics and accidentally stabs the unconscious Reynaldo through the heart with a liposuction cannula. Fleeing the clinic with Reynaldo's body, Rudy calls George, only to be told that he is dead. Now realizing that he has no option left except to flee the country, Rudy returns home, only to find he can't go: his girlfriend, Hollywood actress Heather Chappell, has been kidnapped by Stranahan. Realizing they'll never get paid until Stranahan is no longer a threat to Rudy, Chemo and Maggie join Rudy to confront Stranahan at the stilt house, taking Christina with them. During the confrontation, Stranahan knocks out Chemo and Rudy, and sends Christina, Maggie and Heather back to the mainland. Stranahan then attempts to "jog" Rudy's memory of Victoria Barletta's death by "recreating" the circumstances of the botched nose job, with Rudy as the "patient." Scared, Rudy confesses: he killed Vicki (purely by accident), then got George to get rid of the body. He also confesses to hiring Chemo to kill Stranahan; Chemo is so alarmed (or embarrassed) at Stranahan learning that Chemo agreed to kill him in exchange for a discount on surgery, that he kills Graveline. Stranahan ties Chemo up, calls the police, and swims away. Garcia arrives, and Chemo is arrested. Various plot threads are resolved by the epilogue: Chemo is convicted of murdering Chloe Stranahan, and Rudy Graveline, and sentenced to 17 years in prison; Maggie Gonzalez is convicted of perjury and obstruction of justice, and sentenced to community service, and is later killed in a riot at the Dade County Stockade; Reynaldo Flemm's body is sent, with a phony name attached, to a medical school on Guadeloupe, to serve as a clinical teaching aid. Victoria Barletta's parents receive a suitcase full of money, supposedly a gift from Rudy's estate; "In Your Face!" is canceled after Flemm's mysterious disappearance, and Christina takes a newspaper job in Miami Florida, and purchases a second-hand fishing boat.  