What was Michelangelo 's earliest known work ?
Daniele 's best - known painting is the " Descent from the Cross " in the Trinità dei Monti ( circa 1545 ) , after drawings by Michelangelo ; by an excess of praise this work was at one time grouped with Raphael 's " Transfiguration " and the " Last Communion of St. Jerome " by Domenichino as the most famous pictures in Rome .