Correcting the Minimization Bias in Searches for Small Signals
  We discuss a method for correcting the bias in the limits for small signals if those limits were found based on cuts that were chosen by minimizing a criterion such as sensitivity. Such a bias is commonly present when a "minimization" and an "evaluation" are done at the same time. We propose to use a variant of the bootstrap to adjust the limits. A Monte Carlo study shows that these new limits have correct coverage. 
Wolfgang A. Rolke and Angel M. Lopez