The Semiclassical Instability of de Sitter Space
  The effect of the spontaneous nucleation of black holes in de Sitter space is reviewed, and the main steps of the calculation in Nucl.Phys. B 582, 313, 2000 of the one-loop amplitude of this process are summarized. The existence of such an effect suggests that de Sitter space is not a ground state of quantum gravity with a positive cosmological constant. 
Mikhail S. Volkov