When are crossed products by minimal diffeomorphisms isomorphic?
  This is a survey which discusses the isomorphism problem for both C* and smooth crossed products by minimal diffeomorphisms. For C* crossed products, examples demonstrate the failure of the obvious analog of the Giordano-Putnam-Skau Theorem on minimal homeomorphisms of the Cantor set. For smooth crossed products, there are many open problems. 
N. Christopher Phillips