def read_set_from_columns(file_path, file_name, col_indices=(0, 1), ignore_header=False):
    """Creates a set with the values of the selected columns"""
    result = set()
    with open(file_path + file_name) as file:
        if ignore_header:
            file.readline()
        for line in file:
            fields = line.split('\t')
            if max(col_indices) >= len(fields):
                raise ValueError(f"File does not have the columns requested: {col_indices}")
            for index in col_indices:
                result.add(fields[index].strip())
    return result