def is_simple_locale_with_region(locale):
    """Check if a locale is only an ISO and region code."""
    # Some locale are unicode names, which are not valid
    try:
        lang, sep, qualifier = locale.partition('_')
    except UnicodeDecodeError:
        return False
    if '-' in lang:
        return False
    # Only allow qualifiers that look like a country code, without any suffix
    if qualifier and len(qualifier) == 2:
        return True
    else:
        return False