import csv


def open_tsv_file(tsv_file):
    """
    open one TSV file as list of lists
    one line = one list
    """
    with open(tsv_file, 'r') as f:
        reader = csv.reader(f, delimiter='\t')
        tsv_file_lst_lsts = [line for line in reader if "#" not in line[0]]

    return tsv_file_lst_lsts