def is_metastatic(text, disease):
  """Detect if the metastatic disease is mentioned.

  Use keyword matching to detect if the combination of keywords "metastatic" or "unresectable" with disease's name appears in the sentence.

  Parameters
  ----------
  text : str
      A string or sentence
  disease : str
      A disease's name

  Returns
  -------
  bool
      Return True if "metastatic" or "unresectable" and the disease are mentioned together, False otherwise. 
  
  Examples
  --------
  Import the module

  >>> from biomarker_nlp import biomarker_extraction
  
  Example
  
  >>> txt = "TECENTRIQ, in combination with bevacizumab, is indicated for the treatment of patients with unresectable or metastatic hepatocellular carcinoma (HCC) who have not received prior systemic therapy."
  >>> disease = "hepatocellular carcinoma"
  >>> biomarker_extraction.is_metastatic(text = txt, disease = disease)
  True

  """

  text = text.lower()
  disease = disease.lower()
  if 'metastatic' + " " + disease in text or 'unresectable' + " " + disease in text:
    return True
  else:
    return False