def determine_paired(args) -> bool:
    """
    Determine whether we should work in paired-end mode.
    """
    # Usage of any of these options enables paired-end mode
    return bool(
        args.paired_output
        or args.interleaved
        or args.adapters2
        or args.cut2
        or args.pair_filter
        or args.untrimmed_paired_output
        or args.too_short_paired_output
        or args.too_long_paired_output
        or args.quality_cutoff2
    )