def IC_NIS(ic_cc, ic_ca, ic_pp, ic_pa, p_nis_a, p_nis_c):
    """
    Calculates the predicted binding affinity value
    based on the IC-NIS model.
    """

    return -0.09459*ic_cc + -0.10007*ic_ca + 0.19577*ic_pp + -0.22671*ic_pa \
        + 0.18681*p_nis_a + 0.13810*p_nis_c + -15.9433