#!/usr/bin/env python
# encoding: utf-8
from __future__ import (absolute_import, division,
                        print_function, unicode_literals)
from flask import Flask
from app.datatables import datatables

flask_app = Flask('__name__')
flask_app.register_blueprint(datatables)
flask_app.run()

@@ -185,16 +185,26 @@
 tatables
+_blueprint
  import 

Change blueprint import in local_run.py