eliminate closures in Application
eliminate closures in Application

they cause re-renders

ucscXena/ucsc-xena-client,ucscXena/ucsc-xena-client,ucscXena/ucsc-xena-client,ucscXena/ucsc-xena-client,acthp/ucsc-xena-client,acthp/ucsc-xena-client,ucscXena/ucsc-xena-client,acthp/ucsc-xena-client