When a read has negative strand flag set, reverse-complement it regardless of whether it is mapped or not, and clear the flag.
When a read has negative strand flag set, reverse-complement it regardless of whether it is mapped or not, and clear the flag.

broadinstitute/picard,annkupi/picard,annkupi/picard,nh13/picard,broadinstitute/picard,alecw/picard,broadinstitute/picard,alecw/picard,broadinstitute/picard,nh13/picard,broadinstitute/picard,annkupi/picard,nh13/picard,alecw/picard,annkupi/picard,alecw/picard,nh13/picard