Getting information from various databases and deal with the PDB data.
Getting information from various databases and deal with the PDB data.

- [x] Find all human proteins
    - `BRENDA` has taxonomy info on enzymes
    - `PDB` does provide a json file of human genes related proteins
- [ ] Find expressed organ & localization
    - `Human Protein Atlas` & `COMPARTMENT` from `GeneCards`
    - Corresponding cancer type
- [ ] Filter duplicates (hard, might skip this for now)
    - Sub-structure of same protein
    - Same protein with different resolutions
- [ ] Sort into groups
    - Acidic proteins
    - Alkaline proteins
- [x] Find gene symbol / entrez / Ensembl IDs
    - May match to multiple, but we only have transcriptome data
- [ ] Plot expression of different groups

- expressed proteins under normal conditions, the pK distribution difference?
- Use expression value as a weight
    - Cytosol tumor lower pK

- Use pK to predict pH
    - cell line, fast growing ones should have ribosome (rate limiting) at its optimum pH (7.6)
    - pK distribution should be different

SCP-028/UGA,SCP-028/UGA,SCP-028/UGA,SCP-028/UGA,SCP-028/UGA