A metal complexing property of furosemide and bumetanide: determination of pK and stability constant.
Furosemide and bumetanide have been found to have different pK values and undergo complex formation with several metal ions in dioxane-water solution. pK values of these diuretics were determined. Evidence for complex formation was provided by a drop in pH during complex formation, production of a characteristic color and precipitation.
A metal complexing property of furosemide and bumetanide: determination of pK and stability constant. Furosemide and bumetanide have been found to have different pK values and undergo complex formation with several metal ions in dioxane-water solution. pK values of these diuretics were determined. Evidence for complex formation was provided by a drop in pH during complex formation, production of a characteristic color and precipitation.