Suppressive effect of Newcastle disease virus on the primary and secondary immune responses of hamsters.
The effect of Newcastle disease virus (NDV) on the formation of 19 S haemolytic plaque-forming cells (HPFC) in the secondary immune response and on the formation of 7 S HPFC in both primary and secondary immune responses of hamsters to sheep red blood cells (SRBC) was studied. The 19 S and the 7 S HPFC in the spleens of hamsters injected with SRBC were demonstrated by the direct and indirect Jerne's method, repectively. A single intraperitoneal injection of NDV 5 days prior to primary immunization markedly depressed the number of 7 S HPFC. NDV administered 5 days prior to the second injection of SRBC resulted in a significant decrease in the number of both 19 S and 7 S HPFC. It is asssumed that interferon induced by NDV is responsible for the suppressive effect of the virus on both the primary and secondary immune responses of hamsters to SRBC.
Suppressive effect of Newcastle disease virus on the primary and secondary immune responses of hamsters. The effect of Newcastle disease virus (NDV) on the formation of 19 S haemolytic plaque-forming cells (HPFC) in the secondary immune response and on the formation of 7 S HPFC in both primary and secondary immune responses of hamsters to sheep red blood cells (SRBC) was studied. The 19 S and the 7 S HPFC in the spleens of hamsters injected with SRBC were demonstrated by the direct and indirect Jerne's method, repectively. A single intraperitoneal injection of NDV 5 days prior to primary immunization markedly depressed the number of 7 S HPFC. NDV administered 5 days prior to the second injection of SRBC resulted in a significant decrease in the number of both 19 S and 7 S HPFC. It is asssumed that interferon induced by NDV is responsible for the suppressive effect of the virus on both the primary and secondary immune responses of hamsters to SRBC.