Bufuralol, a new beta-adrenoceptor blocking agent. Part 1: synthesis and structure-activity studies in a series of benzofuran-2-ethanolamines.
The synthesis and resolution of a new beta-adrenoceptor blocking agent, 1-(7-ethylbenzofuran-2-yl)-2-tert.-butylamino-1-hydroxyethane (bufuralol) are described. Structure-activity studies leading to selection of the title compound are discussed.
Bufuralol, a new beta-adrenoceptor blocking agent. Part 1: synthesis and structure-activity studies in a series of benzofuran-2-ethanolamines. The synthesis and resolution of a new beta-adrenoceptor blocking agent, 1-(7-ethylbenzofuran-2-yl)-2-tert.-butylamino-1-hydroxyethane (bufuralol) are described. Structure-activity studies leading to selection of the title compound are discussed.