[Change in the activity of tyrosine aminotransferase in the tissues of rabbits with various levels of corticosteroids in the body].
Experiments were conducted on rabbits. As revealed, hypocoriticism was accompanied by a reduction of the tyrosineaminotranspherase in the liver, muscles and blood plasma; the enzyme activity was unchanged in the brain and the spleen. An increase of the corticosteroid level in the organism after the administration of hydrocortisone to the intact and adrenalectomized animals led to increase of the enzyme activity in the tissues under study; the effect of hydrocortisone action depended on the initial hormonal background in the organism and the duration of the hormone administration. A single ACTH administration to the intact rabbits was accompanied by increase in the enzyme activity in the liver and the spleen, whereas to the adrenalectomized animals--in the brain, muscles and the blood plasma. A repeated administration of both hormones decreased the enzyme activity in the brain and the liver.
[Change in the activity of tyrosine aminotransferase in the tissues of rabbits with various levels of corticosteroids in the body]. Experiments were conducted on rabbits. As revealed, hypocoriticism was accompanied by a reduction of the tyrosineaminotranspherase in the liver, muscles and blood plasma; the enzyme activity was unchanged in the brain and the spleen. An increase of the corticosteroid level in the organism after the administration of hydrocortisone to the intact and adrenalectomized animals led to increase of the enzyme activity in the tissues under study; the effect of hydrocortisone action depended on the initial hormonal background in the organism and the duration of the hormone administration. A single ACTH administration to the intact rabbits was accompanied by increase in the enzyme activity in the liver and the spleen, whereas to the adrenalectomized animals--in the brain, muscles and the blood plasma. A repeated administration of both hormones decreased the enzyme activity in the brain and the liver.