Urinary acidification in renal allografts.
Urinary acid excretion was measured in 35 human renal allograft recipients during the first few days after the onset of diuresis and two months after transplantation. In 16 out of 17 rejection episodes an early significant decrease of renal total net H+ excretion was observed. This urinary acidification impairment preceded the serum creatinine increase. Only few patients showed variations in blood pH and C1-. The acidification defect may be due to the ischaemic changes of rejection. Early impairment of urinary acidification supports a clinical diagnosis of rejection.
Urinary acidification in renal allografts. Urinary acid excretion was measured in 35 human renal allograft recipients during the first few days after the onset of diuresis and two months after transplantation. In 16 out of 17 rejection episodes an early significant decrease of renal total net H+ excretion was observed. This urinary acidification impairment preceded the serum creatinine increase. Only few patients showed variations in blood pH and C1-. The acidification defect may be due to the ischaemic changes of rejection. Early impairment of urinary acidification supports a clinical diagnosis of rejection.