[Influence of ethanol on the in vitro and in vivo drug release from some sustained release tablets (author's transl)].
The in vitro and in vivo liberation of acetylsalicylic acid from sustained release tablets in presence of ethanol is described. Simultaneous uptake of 120 ml commercial brandy resulted in a faster release of the active substance from the tablets prepared with Eudragit ret-l (PM), as has been proved by urinary excretion data. These results were supported by experiments with a pH-endoaradio transmitter and by radiography.
[Influence of ethanol on the in vitro and in vivo drug release from some sustained release tablets (author's transl)]. The in vitro and in vivo liberation of acetylsalicylic acid from sustained release tablets in presence of ethanol is described. Simultaneous uptake of 120 ml commercial brandy resulted in a faster release of the active substance from the tablets prepared with Eudragit ret-l (PM), as has been proved by urinary excretion data. These results were supported by experiments with a pH-endoaradio transmitter and by radiography.