Renal excretion of fluid, electrolytes and hydrogen ions before and during diamox administration in healthy Nigerians.
Twenty-four urine specimens of eleven healthy Nigerians taken during the cool rainy season, were examined before and during diamox (acetazolamide) administration. Mean control volume-output was 1.4 litres containing 109.5 mEq Na+, 46.6 mEq K+ and 120 mEq Cl- ions. Total renal acid excretion was 36.82 partitioned as 14.72 mEq titratable buffer-acid and 22.1 mEq ammonia. During diamox intake, volume-output increased to 2.56 litres with Na+ and K+ contents of 222.4 and 107 mEq respectively, whilst Cl- ions, fell to 2.6 mEq. Daily renal acid excretion was reduced by 25% and titratable buffer acid was absent in most samples but ammonia excretion showed a wide scatter with a range of 6.5-60.8 mEq. The probable explanations for the lower potassium and total acid excretions during the control period as well as the pattern of ammonia excretion during diamox therapy are discussed.
Renal excretion of fluid, electrolytes and hydrogen ions before and during diamox administration in healthy Nigerians. Twenty-four urine specimens of eleven healthy Nigerians taken during the cool rainy season, were examined before and during diamox (acetazolamide) administration. Mean control volume-output was 1.4 litres containing 109.5 mEq Na+, 46.6 mEq K+ and 120 mEq Cl- ions. Total renal acid excretion was 36.82 partitioned as 14.72 mEq titratable buffer-acid and 22.1 mEq ammonia. During diamox intake, volume-output increased to 2.56 litres with Na+ and K+ contents of 222.4 and 107 mEq respectively, whilst Cl- ions, fell to 2.6 mEq. Daily renal acid excretion was reduced by 25% and titratable buffer acid was absent in most samples but ammonia excretion showed a wide scatter with a range of 6.5-60.8 mEq. The probable explanations for the lower potassium and total acid excretions during the control period as well as the pattern of ammonia excretion during diamox therapy are discussed.