The effects of purified cathepsin D infusions in intact animals.
Cathepsin D, a potent acid proteinase, has been implicated in the pathogenesis of circulatory shock. The infusion of purified preparations of cathepsin D into intact animals resulted in significant depressions in core body temperature but failed to reproduce the cardiovascular disturbances seen in shock states.
The effects of purified cathepsin D infusions in intact animals. Cathepsin D, a potent acid proteinase, has been implicated in the pathogenesis of circulatory shock. The infusion of purified preparations of cathepsin D into intact animals resulted in significant depressions in core body temperature but failed to reproduce the cardiovascular disturbances seen in shock states.