The effects of PaCO2 reduction on regional cerebral blood flow in the acute phase of brain injury.
In 26 unconscious patients with brain injuries, regional cerebral blood flow (rCBF) was measured with a 16-channel Cerebrograph before and after acute reduction of PaCO2. The intra-arterial 133xenon washout technique was used, and CBF was calculated regionally as initial slope index or stochastic flow. The CO2 reactivity was calculated as deltaln CBV/deltaPaCO2. In supratentorial cortical lesions, an acute fall in PaCO2 increased the homogeneity of the regional flow pattern (decrease in the standard deviation of the regional flow values), and reduced the number of focal hyperaemic regions (tissue peaks). The CO2 reactivity in tissue peak regions was generally higher than in regions without tissue peaks. In severely injured patients with a poor outcome (dementia, vegetative survival or death), inverse steal reaction was accounted for in 11% of all regions, but only in 3% of the regions in patients who survived without dementia. Inverse steal reaction was most frequently seen during the first 3 days after the trauma. In repeated CBF studies, an increase in the CO2 reactivity with time was observed after the acute trauma. In comparison with the CO2 reactivity found in normocapnic awake subjects, this increase was higher than expected in several cases.
The effects of PaCO2 reduction on regional cerebral blood flow in the acute phase of brain injury. In 26 unconscious patients with brain injuries, regional cerebral blood flow (rCBF) was measured with a 16-channel Cerebrograph before and after acute reduction of PaCO2. The intra-arterial 133xenon washout technique was used, and CBF was calculated regionally as initial slope index or stochastic flow. The CO2 reactivity was calculated as deltaln CBV/deltaPaCO2. In supratentorial cortical lesions, an acute fall in PaCO2 increased the homogeneity of the regional flow pattern (decrease in the standard deviation of the regional flow values), and reduced the number of focal hyperaemic regions (tissue peaks). The CO2 reactivity in tissue peak regions was generally higher than in regions without tissue peaks. In severely injured patients with a poor outcome (dementia, vegetative survival or death), inverse steal reaction was accounted for in 11% of all regions, but only in 3% of the regions in patients who survived without dementia. Inverse steal reaction was most frequently seen during the first 3 days after the trauma. In repeated CBF studies, an increase in the CO2 reactivity with time was observed after the acute trauma. In comparison with the CO2 reactivity found in normocapnic awake subjects, this increase was higher than expected in several cases.