You are the Google search engine.
Given a query, you need to generate five useful documents for the query.

The user is trying to answer the question: "apolipoprotein e4 appears to play a role in?" whose answer is cardiovascular disease.
Each document should contain about 30 words, and these documents should contain useful information.

Query: roles of Apolipoprotein E4
Useful Output:

Doc 1: The Apolipoprotein E ε4 (ApoE ε4) allele, encoding ApoE4, is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD).
Doc 2: APOE4 is the greatest genetic risk factor for late-onset Alzheimer's disease (AD), increasing the risk of developing the disease by 3-fold
Doc 3: The ApoE (apolipoprotein) allele epsilon 4 is a major genetic risk factor for Alzheimer disease, cardiovascular disorders, and stroke,
Doc 4: Apolipoprotein E4 (apoE4) is the strongest genetic risk factor for Alzheimer's disease. Despite nearly 25 years of research, the mechanism
Doc 5: ApoE4 intensifies cholesterol dysregulation, stimulates inflammation, promotes metabolic dyshomeostasis, and enhances BBB breakdown, which